DEPT OF PATHOLOGY
| Researcher : Au Yeung KHR |
| Project Title: | The role of SOX9 in mature B and T cell lymphomas |
| Investigator(s): | Au Yeung KHR |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2017 |
| Project Title: | The epidemiology, clinicopathologic features, and treatment outcome of double-hit B-cell lymphomas |
| Investigator(s): | Au Yeung KHR, Kwong YL, Khong PL |
| Department: | Pathology |
| Source(s) of Funding: | The Hong Kong College of Pathologists |
| Start Date: | 07/2017 |
| Project Title: | Molecular characterization of paediatric B-cell non-Hodgkin lymphomas in Hong Kong |
| Investigator(s): | Au Yeung KHR, Chiang AKS |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2019 |
| List of Research Outputs |
| Au Yeung K.H.R., Burkhardt B., Woessmann W. and Klapper W., CD38 is not expressed in pediatric ALK-positive anaplastic large cell lymphoma, Pediatric Blood & Cancer. 2019, 66: e27541. |
| Au Yeung K.H.R., Ilske O., Siebert R., Woessmann W., Burkhardt B. and Klapper W., Clinical and pathological features of the new WHO-entities large B-cell lymphoma with IRF4 rearrangement and Burkitt-like lymphoma with 11q aberration within the NHL-BFM Group, Sixth International Symposium on Childhood, Adolescent and Young Adult Non-Hodgkin Lymphoma. British Journal of Haematology, Wiley-Blackwell, 2018, 182 Supplement 1: 84. |
| Au Yeung K.H.R., Padilla L.A., Burkhardt B., Woessmann W. and Klapper W., Features of Pediatric B-lymphoblastic lymphoma with KMT2A rearrangements in the German NHL-BFM Group, The 108th Annual Meeting of the Japanese Society of Pathology. Tokyo, Japan, The Japanese Society of Pathology, 2019, 108 (1): 420. |
| Chu H., Chan C.M., Zhang X., Wang Y., Yuan S., Zhou J., Au Yeung K.H.R., Sze K.H., Yang D., Shuai H.V., Hou Y., Li C., Zhao X., Poon K.M., Leung A.S.P., Yeung M.L., Yan J., Lu G., Jin D., Gao G.F., Chan J.F.W. and Yuen K.Y., Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells, Journal of Biological Chemistry. 2018, 293: 11709-11726. |
| Lau S.K.P., Wong Y.M., Tsang C.C., Ahmed S.S., Au Yeung K.H.R., Yuen K.Y., Wernery U. and Woo P.C.Y., Discovery and sequence analysis of four deltacoronaviruses from birds in the Middle East reveal interspecies jumping with recombination as a potential mechanism for avian-to-avian and avian-to-mammalian transmission, Journal of Virology. 2018, 92: e00265-18. |
| Schnotalle P., Koch K., Au Yeung K.H.R., Reinke S., Winter K., Loeffler M., Braumann U.D. and Klapper W., T-Cell Clustering in Neoplastic Follicles of Follicular Lymphoma, Cancer Microenvironment. 2018. |
| Wagener R., Seufert J., Raimondi F., Bens S., Kleinheinz K., Nagel I., Altmüller J., Thiele H., Hübschmann D., Kohler C.W., Nürnberg P., Au Yeung K.H.R., Burkhardt B., Horn H., Leoncini L., Jaffe E.S., Ott G., Rymkiewicz G., Schlesner M., Russell R.B., Klapper W. and Siebert R., The mutational landscape of Burkitt-like lymphoma with 11q aberration is distinct from that of Burkitt lymphoma, Blood. 2019, 133: 962-966. |
| Researcher : Bao HR |
| List of Research Outputs |
| Lee D., XU M., CHIU K.C., Leibold J., Tse P.W., Bao H.R., Yuen W.H., Chan Y.K., LAI K.H., Chin W.C., Chan F.F., Cheung T.T., Chok K.S.H., Wong C.M., Lowe S.W., Ng I.O.L. and Wong C.C.L., Induction of oxidative stress through inhibition of thioredoxin reductase 1 is an effective therapeutic approach for hepatocellular carcinoma, Hepatology. 2019, 69: 1768-1786. |
| Researcher : Beh SL |
| Project Title: | The attitudes of doctors toward rape victims |
| Investigator(s): | Beh SL |
| Department: | Pathology |
| Source(s) of Funding: | Other Funding Scheme |
| Start Date: | 06/1993 |
| List of Research Outputs |
| Beh S.L., Medical Manslaughter, Hong Kong Medical Journal. Hong Kong, Hong Kong Academy of Medicine, 2018, 24: 333-4. |
| Wu Y.H. and Beh S.L., The porcelain autopsy table and early postmortem examinations in Hong Kong, Hong Kong Medical Journal. Hong Kong, 2018, 24(4): 434-435. |
| Researcher : CHEN L |
| List of Research Outputs |
| CHEN L., Wong G.W., Wong T.L.I., Wang J. and Cheung A.N.Y., Aberrant Expression of ROS1 is Uncommon in Ovarian Cancer, In: Chen L, Wong OGW, Wong ITL, Wang J, Cheung AN., AACR New Horizons in Cancer Research Conference. May 3-5, 2019, Shenzhen, China.. 2019. |
| Researcher : CHIU KC |
| List of Research Outputs |
| Lee D., XU M., CHIU K.C., Leibold J., Tse P.W., Bao H.R., Yuen W.H., Chan Y.K., LAI K.H., Chin W.C., Chan F.F., Cheung T.T., Chok K.S.H., Wong C.M., Lowe S.W., Ng I.O.L. and Wong C.C.L., Induction of oxidative stress through inhibition of thioredoxin reductase 1 is an effective therapeutic approach for hepatocellular carcinoma, Hepatology. 2019, 69: 1768-1786. |
| Researcher : Chan AOK |
| List of Research Outputs |
| Chan H.S.S., Van Alfen N., Thuestad I.J., Ip J.K.J., Chan A.O.K., MAK C.C.Y., Chung B.H.Y., Aad V.E.R.R.I.P.S. and Erik-Jan K.A.M.S.T.E.E.G., A recurrent de novo DYNC1H1 tail domain mutation causes spinal muscular atrophy with lower extremity predominance, learning difficulties and mild brain abnormality, Neuromuscular Disorders. 2018. |
| Researcher : Chan AS |
| List of Research Outputs |
| Chan A.S., Yan H.H.N. and Leung S.Y., Breakthrough Moments: Organoid Models of Cancer, Cell Stem Cell. 2019, 24: 839-840. |
| TONG Y., SUN J., WONG C.F., KANG Q., RU B., WONG C., Chan A.S., Leung S.Y. and Zhang J., MICMIC: identification of DNA methylation of distal regulatory regions with causal effects on tumorigenesis, Genome Biology. 2018, 19. |
| Yan H.H.N., Siu H.C., Law S.Y.K., Ho R.S.L., Yue S.K.S., Tsui W.Y., Chan D., Chan A.S., Ma S.K.Y., Lam K.O., Bartfeld S., Man H.Y., Lee C.H., Chan A.S.Y., Wong W.H.J., Cheng S.W.P., Chan K.W., Zhang J., Shi J., Fan X., Kwong D.L.W., Mak T.W., Yuen S.T., Clevers H. and Leung S.Y., A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening, Cell Stem Cell. 2018. |
| Yan H.H.N., Chan D., Siu H.C., Law S.Y.K., Ho R.S.L., Tsui W.Y., Yue S.K.S., Chan A.S., Lee C.H., Chan A.S.Y., Chan K.W., Leung H.C., Hui H.S., Lam K.O., Kwong D.L.W., Mak T.W., Clevers H. and Leung S.Y., Establishment of a large-scale drug sensitivity screening platform on gastric cancer organoid cultures with potential to guide treatment. , American Association for Cancer Research (AACR) and Korean Cancer Association (KCA) Joint Conference on Precision Medicine in Solid Tumors. 2018. |
| Researcher : Chan ASY |
| List of Research Outputs |
| Yan H.H.N., Siu H.C., Law S.Y.K., Ho R.S.L., Yue S.K.S., Tsui W.Y., Chan D., Chan A.S., Ma S.K.Y., Lam K.O., Bartfeld S., Man H.Y., Lee C.H., Chan A.S.Y., Wong W.H.J., Cheng S.W.P., Chan K.W., Zhang J., Shi J., Fan X., Kwong D.L.W., Mak T.W., Yuen S.T., Clevers H. and Leung S.Y., A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening, Cell Stem Cell. 2018. |
| Yan H.H.N., Chan D., Siu H.C., Law S.Y.K., Ho R.S.L., Tsui W.Y., Yue S.K.S., Chan A.S., Lee C.H., Chan A.S.Y., Chan K.W., Leung H.C., Hui H.S., Lam K.O., Kwong D.L.W., Mak T.W., Clevers H. and Leung S.Y., Establishment of a large-scale drug sensitivity screening platform on gastric cancer organoid cultures with potential to guide treatment. , American Association for Cancer Research (AACR) and Korean Cancer Association (KCA) Joint Conference on Precision Medicine in Solid Tumors. 2018. |
| Researcher : Chan CY |
| List of Research Outputs |
| Law C.T., Tsang F.H., Chan C.Y., XU M., Lai R.K., Ho D.W.H., Lee J.K.M., Wong C.C.L., Ng I.O.L. and Wong C.M., Chromatin remodeler HELLS is an epigenetic driver for hepatocellular carcinoma progression. , Hepatology . 2019. |
| Researcher : Chan D |
| List of Research Outputs |
| Yan H.H.N., Siu H.C., Law S.Y.K., Ho R.S.L., Yue S.K.S., Tsui W.Y., Chan D., Chan A.S., Ma S.K.Y., Lam K.O., Bartfeld S., Man H.Y., Lee C.H., Chan A.S.Y., Wong W.H.J., Cheng S.W.P., Chan K.W., Zhang J., Shi J., Fan X., Kwong D.L.W., Mak T.W., Yuen S.T., Clevers H. and Leung S.Y., A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening, Cell Stem Cell. 2018. |
| Yan H.H.N., Chan D., Siu H.C., Law S.Y.K., Ho R.S.L., Tsui W.Y., Yue S.K.S., Chan A.S., Lee C.H., Chan A.S.Y., Chan K.W., Leung H.C., Hui H.S., Lam K.O., Kwong D.L.W., Mak T.W., Clevers H. and Leung S.Y., Establishment of a large-scale drug sensitivity screening platform on gastric cancer organoid cultures with potential to guide treatment. , American Association for Cancer Research (AACR) and Korean Cancer Association (KCA) Joint Conference on Precision Medicine in Solid Tumors. 2018. |
| Researcher : Chan FF |
| List of Research Outputs |
| Lee D., XU M., CHIU K.C., Leibold J., Tse P.W., Bao H.R., Yuen W.H., Chan Y.K., LAI K.H., Chin W.C., Chan F.F., Cheung T.T., Chok K.S.H., Wong C.M., Lowe S.W., Ng I.O.L. and Wong C.C.L., Induction of oxidative stress through inhibition of thioredoxin reductase 1 is an effective therapeutic approach for hepatocellular carcinoma, Hepatology. 2019, 69: 1768-1786. |
| Researcher : Chan KK |
| List of Research Outputs |
| TAN H.W., Leung C.O., Chan K.K., Ho D.W.H., Leung M.S., Wong C.M., Ng I.O.L. and Lo C.L.R., Deregulated GATA6 modulates stem cell-like properties and metabolic phenotype in hepatocellular carcinoma, Int J Cancer. 2019. |
| Researcher : Chan KS |
| List of Research Outputs |
| TAN H.W., LEUNG O.N., Chan K.S., Ho D.W.H., LEUNG M.S., Wong C.M., Ng I.O.L. and Lo C.L.R., Deregulated Gata6 Modulates Stem Cell‐like Properties And Metabolic Phenotype In Hepatocellular Carcinoma, International Journal Of Cancer. 2019, 145: 1860-1873. |
| Researcher : Chan KW |
| Project Title: | Identification, Characterization and Therapeutic Targeting of Tumourigenic Liver Cancer Stem Cells |
| Investigator(s): | Chan KW, Guan X |
| Department: | Pathology |
| Source(s) of Funding: | Michael and Betty Kadoorie Cancer Genetics Research Programme (MBKCGRP) II |
| Start Date: | 01/2008 |
| List of Research Outputs |
| Li B., Hong P., Zheng C.C., Dai W., Chen W.Y., Yang Q.S., Han L., Tsao G.S.W., Chan K.T., Lee N.P.Y., Law S.K., Xu L.Y., Li E.M., Chan K.W., Qin Y.R., Guan X., Lung M.L., He Q.Y., Xu W.W. and Cheung A., Identification of miR-29c and its Target FBXO31 as a Key Regulatory Mechanism in Esophageal Cancer Chemoresistance: Functional Validation and Clinical Significance., Theranostics 2019. 2019, 9(6):1599-1613. |
| Li B., Hong P., Zheng C.-.C., Dai W., Chen W.-.Y., Yang Q.-.S., HAN L., Tsao G.S.W., Chan K.T., Lee N.P.Y., Law S.Y.K., Xu L.Y., Li E.M., Chan K.W., Qin Y.R., Guan X., Lung M.L., He Q.-.Y., Xu W. and Cheung A., Identification of miR-29c and its Target FBXO31 as a Key Regulatory Mechanism in Esophageal Cancer Chemoresistance: Functional Validation and Clinical Significance, Theranostics. 2019, 9: 1599-1613. |
| Yan H.H.N., Siu H.C., Law S.Y.K., Ho R.S.L., Yue S.K.S., Tsui W.Y., Chan D., Chan A.S., Ma S.K.Y., Lam K.O., Bartfeld S., Man H.Y., Lee C.H., Chan A.S.Y., Wong W.H.J., Cheng S.W.P., Chan K.W., Zhang J., Shi J., Fan X., Kwong D.L.W., Mak T.W., Yuen S.T., Clevers H. and Leung S.Y., A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening, Cell Stem Cell. 2018. |
| Yan H.H.N., Chan D., Siu H.C., Law S.Y.K., Ho R.S.L., Tsui W.Y., Yue S.K.S., Chan A.S., Lee C.H., Chan A.S.Y., Chan K.W., Leung H.C., Hui H.S., Lam K.O., Kwong D.L.W., Mak T.W., Clevers H. and Leung S.Y., Establishment of a large-scale drug sensitivity screening platform on gastric cancer organoid cultures with potential to guide treatment. , American Association for Cancer Research (AACR) and Korean Cancer Association (KCA) Joint Conference on Precision Medicine in Solid Tumors. 2018. |
| Researcher : Chan KW |
| List of Research Outputs |
| Li B., Hong P., Zheng C.C., Dai W., Chen W.Y., Yang Q.S., Han L., Tsao G.S.W., Chan K.T., Lee N.P.Y., Law S.K., Xu L.Y., Li E.M., Chan K.W., Qin Y.R., Guan X., Lung M.L., He Q.Y., Xu W.W. and Cheung A., Identification of miR-29c and its Target FBXO31 as a Key Regulatory Mechanism in Esophageal Cancer Chemoresistance: Functional Validation and Clinical Significance., Theranostics 2019. 2019, 9(6):1599-1613. |
| Li B., Hong P., Zheng C.-.C., Dai W., Chen W.-.Y., Yang Q.-.S., HAN L., Tsao G.S.W., Chan K.T., Lee N.P.Y., Law S.Y.K., Xu L.Y., Li E.M., Chan K.W., Qin Y.R., Guan X., Lung M.L., He Q.-.Y., Xu W. and Cheung A., Identification of miR-29c and its Target FBXO31 as a Key Regulatory Mechanism in Esophageal Cancer Chemoresistance: Functional Validation and Clinical Significance, Theranostics. 2019, 9: 1599-1613. |
| Yan H.H.N., Siu H.C., Law S.Y.K., Ho R.S.L., Yue S.K.S., Tsui W.Y., Chan D., Chan A.S., Ma S.K.Y., Lam K.O., Bartfeld S., Man H.Y., Lee C.H., Chan A.S.Y., Wong W.H.J., Cheng S.W.P., Chan K.W., Zhang J., Shi J., Fan X., Kwong D.L.W., Mak T.W., Yuen S.T., Clevers H. and Leung S.Y., A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening, Cell Stem Cell. 2018. |
| Yan H.H.N., Chan D., Siu H.C., Law S.Y.K., Ho R.S.L., Tsui W.Y., Yue S.K.S., Chan A.S., Lee C.H., Chan A.S.Y., Chan K.W., Leung H.C., Hui H.S., Lam K.O., Kwong D.L.W., Mak T.W., Clevers H. and Leung S.Y., Establishment of a large-scale drug sensitivity screening platform on gastric cancer organoid cultures with potential to guide treatment. , American Association for Cancer Research (AACR) and Korean Cancer Association (KCA) Joint Conference on Precision Medicine in Solid Tumors. 2018. |
| Researcher : Chan LK |
| Project Title: | The functional significance of RalA: regulations and therapeutic implication in liver cancer |
| Investigator(s): | Chan LK, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2019 |
| List of Research Outputs |
| Chan L.K. and Ng I.O.L., Proteomic profiling in liver cancer: another new page, Translational Gastroenterology and Hepatology. AME Publishing Company, 2019, 4: 47. |
| Ho D.W.H., Tsui Y.M., Sze M.F., Chan L.K., Cheung T.T., Cheng L., Lee E., Wu A.R., Sham P.C., Tsui S.K.W., Lee T.K.W. and Ng I.O.L., Single-Cell Transcriptome Sequencing Reveals Intra-Tumor Heterogeneity and Rare Stemness-Related Cell Subpopulation in Hepatocellular Carcinoma, 12th Annual Conference of the International Liver Cancer Association. 2018. |
| Ho D.W.H., Tsui Y.M., Sze M.F., Chan L.K., Cheung T.T., Cheng L., Lee E., Wu A.R., Sham P.C., Tsui S.K., Lee T.K. and Ng I.O.L., Single-Cell Transcriptome Sequencing Reveals Intra-Tumor Heterogeneity and Rare Stemness-Related Cell Subpopulation in Hepatocellular Carcinoma, 9th Asia-Pacific Primary Liver Cancer Expert Meeting. 2018. |
| Ma W., Ho D.W.H., Sze M.F., Tsui Y.M., Chan L.K., Lee E. and Ng I.O.L., APOBEC3B promotes hepatocarcinogenesis and metastasis through novel deaminase‐independent activity, Molecular Carcinogenesis. 2019, 58: 643-653. |
| Zhao L., Chan L.K., Ho D.W.H., Tsui Y.M., Sze M.F., Zhang X., Lee M.F. and Ng I.O.L., RalA is frequently up-regulated in human hepatocellular carcinoma and promotes metastasis and cancer stemness, AACR (American Association for Cancer Research) Annual Meeting 2018. |
| Researcher : Chan SWG |
| List of Research Outputs |
| Li C., Yap Y.H.D., Chan S.W.G., Wen Y., Li H., Tang S.O.C., Li X., Li X. and Chan D.T.M., Clinical Outcomes and Clinico-pathological Correlations in Lupus Nephritis with Kidney Biopsy Showing Thrombotic Microangiopathy, The Journal of Rheumatology. 2019, jrheum.180773. |
| Researcher : Chan TL |
| Project Title: | Molecular characterisation of the serrated neoplasia pathway and its role in the development of colorectal cancer with mismatch repair deficiency |
| Investigator(s): | Chan TL, Leung SY, Yuen ST |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2005 |
| Project Title: | Outstanding Young Researcher Award 2007-2008 |
| Investigator(s): | Chan TL |
| Department: | Pathology |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 10/2008 |
| Project Title: | The role of DNA methylation in chromosomal instability in early onset Colorectal Cancer |
| Investigator(s): | Chan TL |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2012 |
| Researcher : Chan YK |
| Project Title: | Validating and examining SNPs identified from genome-wide scanning for disease susceptibility to HBV-related liver cancer in Chinese population |
| Investigator(s): | Chan YK, Ng IOL, Wong CM |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2010 |
| Researcher : Chan YK |
| List of Research Outputs |
| Lee D., XU M., CHIU K.C., Leibold J., Tse P.W., Bao H.R., Yuen W.H., Chan Y.K., LAI K.H., Chin W.C., Chan F.F., Cheung T.T., Chok K.S.H., Wong C.M., Lowe S.W., Ng I.O.L. and Wong C.C.L., Induction of oxidative stress through inhibition of thioredoxin reductase 1 is an effective therapeutic approach for hepatocellular carcinoma, Hepatology. 2019, 69: 1768-1786. |
| Researcher : Chau KM |
| List of Research Outputs |
| Khoo U.S., MOK K.C., Man P.S., Chau K.M., Lee T.K. and Gong C., Hyperpolarization-activated cyclic nucleotide-gated channel (HCN) blocker, Ivabradine, a novel potential targeted treatment for triple-negative breast cancer., 30th EORTC-NCI-AACR Symposium, Dublin, Ireland. 13-16 November 2018.. 2018. |
| Researcher : Chen WYW |
| Project Title: | Doris Zimmern HKU-Cambridge Hughes Hall Fellowships 2010-11 |
| Investigator(s): | Chen WYW |
| Department: | Pathology |
| Source(s) of Funding: | Doris Zimmern HKU-Cambridge Hughes Hall Fellowships |
| Start Date: | 09/2010 |
| Researcher : Cheng L |
| List of Research Outputs |
| Ho D.W.H., Tsui Y.M., Sze M.F., Chan L.K., Cheung T.T., Cheng L., Lee E., Wu A.R., Sham P.C., Tsui S.K.W., Lee T.K.W. and Ng I.O.L., Single-Cell Transcriptome Sequencing Reveals Intra-Tumor Heterogeneity and Rare Stemness-Related Cell Subpopulation in Hepatocellular Carcinoma, 12th Annual Conference of the International Liver Cancer Association. 2018. |
| Ho D.W.H., Tsui Y.M., Sze M.F., Chan L.K., Cheung T.T., Cheng L., Lee E., Wu A.R., Sham P.C., Tsui S.K., Lee T.K. and Ng I.O.L., Single-Cell Transcriptome Sequencing Reveals Intra-Tumor Heterogeneity and Rare Stemness-Related Cell Subpopulation in Hepatocellular Carcinoma, 9th Asia-Pacific Primary Liver Cancer Expert Meeting. 2018. |
| Researcher : Cheng SWP |
| List of Research Outputs |
| Yan H.H.N., Siu H.C., Law S.Y.K., Ho R.S.L., Yue S.K.S., Tsui W.Y., Chan D., Chan A.S., Ma S.K.Y., Lam K.O., Bartfeld S., Man H.Y., Lee C.H., Chan A.S.Y., Wong W.H.J., Cheng S.W.P., Chan K.W., Zhang J., Shi J., Fan X., Kwong D.L.W., Mak T.W., Yuen S.T., Clevers H. and Leung S.Y., A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening, Cell Stem Cell. 2018. |
| Researcher : Cheung ANY |
| Project Title: | Selecting most suitable students for production of best medical doctors-which criteria should we use? |
| Investigator(s): | Cheung ANY, Patil NG, Ip MSM, Chan LC |
| Department: | Pathology |
| Source(s) of Funding: | Leung Kau Kui Research and Teaching Endowment Fund - Teaching Grants |
| Start Date: | 02/2005 |
| Project Title: | Folate and folate receptor alpha in ovarian cancers |
| Investigator(s): | Cheung ANY, Siu KY |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2007 |
| Project Title: | Akt and p21-activated kinase signaling pathways in gestational trophoblastic disease |
| Investigator(s): | Cheung ANY, Ngan HYS, Siu KY |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2007 |
| Project Title: | FBI-1 in ovarian carcinogenesis and progression |
| Investigator(s): | Cheung ANY, Siu KY, Ngan HYS |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2009 |
| Project Title: | HPV detection as an adjunct for triage of atypical cervical cytology in screening for cervical cancer |
| Investigator(s): | Cheung ANY, Ngan HYS |
| Department: | Pathology |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 02/2012 |
| Project Title: | Outstanding Research Student Supervisor Award 2011-12 |
| Investigator(s): | Cheung ANY |
| Department: | Pathology |
| Source(s) of Funding: | Outstanding Research Student Supervisor Award |
| Start Date: | 01/2013 |
| Project Title: | Placental biology of Down Syndrome in relation to increased gene dosage |
| Investigator(s): | Cheung ANY, Wong GW, Ngan HYS |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2014 |
| Project Title: | p53 related proteins and gestational trophoblastic disease |
| Investigator(s): | Cheung ANY, Wong GW, Ngan HYS |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2014 |
| Project Title: | p21 activated kinase 4 and ovarian cancer chemoresistance |
| Investigator(s): | Cheung ANY, Ngan HYS, Wong GW |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2016 |
| Completion Date: | 09/2019 |
| Project Title: | Oxidative phosphorylation in ovarian carcinoma and its effect on cancer stemness |
| Investigator(s): | Cheung ANY, Chan KK, Wong GW |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| Completion Date: | 06/2019 |
| Project Title: | Characterizing the gene transcription mechanism of p21-activated kinase 4 in ovarian cancer |
| Investigator(s): | Cheung ANY, Wong TLI, Wong GW |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2018 |
| Project Title: | 32nd International Papillomavirus Conference; CERVICAL CANCER SCREENING IN AOGIN COUNTRIES: WHAT ARE THE OPTIONS? |
| Investigator(s): | Cheung ANY |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2018 |
| Project Title: | A study on APP overdosage mediated ER stress in Down syndrome placenta |
| Investigator(s): | Cheung ANY, Wong GW |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2019 |
| List of Research Outputs |
| CHEN L., Wong G.W., Wong T.L.I., Wang J. and Cheung A.N.Y., Aberrant Expression of ROS1 is Uncommon in Ovarian Cancer, In: Chen L, Wong OGW, Wong ITL, Wang J, Cheung AN., AACR New Horizons in Cancer Research Conference. May 3-5, 2019, Shenzhen, China.. 2019. |
| Cheung A.N.Y., 1.) Ovarian cancers – Heterogeneity and Implications 2.) Clear cell carcinoma of female genital tract, Pathology 100th Anniversary & 7th Hong Kong Pathology Forum, Hong Kong, 25-26 January, 2019. . 2019. |
| Cheung A.N.Y., Adenological abnormalities in cervical cytology , 宫颈细胞学中的腺性异常, The 5th Conference of Chinese Society for Colposcopy and Cervical Pathology, 10-12 May 2019, Shenzhen, China. 第五届全国阴道镜与宫颈病 理学(CSCCP)大会, 2019. |
| Cheung A.N.Y., Automated Imager Cytology Screening and HPV Test in AOGIN Countries, 32nd International Papillomavirus Conference & Clinical and Public Health Workshops, October 2nd-6th 2018, Sydney, Australia. 2018. |
| Cheung A.N.Y., Clear-cell carcinoma, 透明细胞癌, 香港大学深圳医院第二届妇科肿瘤高峰论坛, 2019年4月12-14日, 深圳. 2019. |
| Cheung A.N.Y., Glandular abnormalities in cervical cytology, Conference of Chinese Society for Colposcopy and Cervical Pathology 18th, 21st May, Shenzhen, China. 2019. |
| Cheung A.N.Y., Screening & Management - Implementation, Evaluation and Impact , The 17th Annual Meeting of National Cervical Cancer Consortium & The Regional Conference of Asia Oceania Research Organization on Genital Infections and Neoplasia and 17th NCCC & AOGIN 2019, 26-28 April 2019, Beijing, China. 2019. |
| Cheung A.N.Y., Will Frozen section diagnosis be extinct due to replacement by other techniques?, 冰冻切片诊断是否会因其他技术的替代而灭绝？, Seminar on Diagnosis and Risk of Intraoperative Frozen Section Diagnosis organized by Chinese Academy of Science Shenzhen Tumour Hospital, 25 May 2019, Shenzhen China. 手术中的病理诊断价值 与风险研讨班暨临床病 理诊断与新技术应用进 展高峰论坛, 中国医 学科学院肿瘤医院深圳 医院, 2019年5月25-26 日, 广东省深圳市, 2019. |
| Cheung A.N.Y., 分子病理技术在妇瘤中的应用, 2019年全国女性生殖系统病理学进展研讨会暨第5次疑难病理读片会, 2019年6月21日-23 日, 江苏省南京市. 2019. |
| Cheung A.N.Y., 卵巢癌病理诊断规范, 广东省医学学术直通车暨中华医学会病理学分会基层病理培训-广东东莞站, 2019年3月23 日, 广东东莞. 2019. |
| Cheung A.N.Y., 女性生殖系统透明细胞癌病理研究进展, 中华医学会病理学分会第二十四次学术会议暨第八届中国病理年会,2018年10月11～14 日,四川省成都市. 2018. |
| Cheung A.N.Y., 数字病理学的应用 - 香港经验的分享, AI数字病理项目试点研讨会, 主办:广东省粤港澳合作促进会医药卫生大健康委员会, 2019 年4月19日, 中国广州. 2019. |
| Ip P.C.P., Wang Y. and Cheung A.N.Y., Complications of Early Pregnancy and Gestational Trophoblastic Diseases, In: Zheng WX, Fadare O, Quick CM, Shen DH, Guo DH, Gynecologic and Obstetric Pathology. Singapore, Springer, 2019, 2: 427-458. |
| Ip P.C.P., Wang S.Y., Wong G.W., Chow K.L., Lee H.Y.H., Cheung A.N.Y. and Tse K.Y., Napsin A, Hepatocyte Nuclear Factor-1-Beta (HNF-1β), Estrogen and Progesterone Receptors Expression in Arias-Stella Reaction, The American Journal of Surgical Pathology. 2019, 43: 325-333. |
| LI X., Ng A.S., Mak C.Y., Zhou Y., Cheung A.N.Y. and Cheung W.T.L., Characterization of PIK3R1 driver aberrations reveals novel therapeutic responses in gynecological cancers., 14th International Symposium on Healthy Aging “Embrace the Golden Years”. 2019. |
| LI X., Mak C.Y., Zhou Y., Cheung A.N.Y. and Cheung W.T.L., Decreased PIK3R1 expression activates AKT and STAT3 in ovarian cancer, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019. |
| LI X., Mak C.Y., Zhou Y., Chao W., Wong E.S.Y., Sharma R., Lu Y., Cheung A.N.Y., Mills G.B. and Cheung W.T.L., Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer, Nature Communications. 2019, 10: 716. |
| LI X., Mak C.Y., Cheung A.N.Y., Mills G.B. and Cheung W.T.L., p85α alters Gab2 phosphorylation profile in ovarian cancer, American Association of Cancer Research (AACR) Annual Meeting 2019. |
| Lam T.H., Wong K.H., Chan K.K.L., Chan M.C.M., Chan D.V.K., Cheung A.N.Y., Fan C.Y.M., Ho D., Hui E.P., Lam K.O., Law C.K., Law W.L., Loong H.H.F., Ngan R.K.C., Tsang T.H.F., Wong M.C.S., Yeung R.M.W. and Ying A.C.H., Recommendations on prevention and screening for colorectal cancer in Hong Kong, Hong Kong Medical Journal. 2018, 24(5): 521-6. |
| Leung T.H.Y., Tang W.M., Siu K.Y., Chan D.W., Chan K.K.L., Cheung A.N.Y. and Ngan H.Y.S., CD71(+) population enriched by HPV-E6 protein promotes cancer aggressiveness and radioresistance in cervical cancer cells, Molecular Cancer Research. 2019, molcanres.0068.2019. |
| Liu S., Chan K.K.L., Chu K.H., Ngu S.F., Chu M.Y.M., Tse K.Y., Wei N., Lau S.K., Cheung A.N.Y. and Ngan H.Y.S., Comparison of Roche cobas test and HC2 test for the detection of high-risk HPV in a population-based study., 32nd International Papillomavirus Conference. 2018. |
| Liu S., Chan K.K.L., Chu K.H., Wei N., Lau S.K., Ngu S.F., Chu M.Y.M., Tse K.Y., Ip P.C.P., Ng E.K.O., Cheung A.N.Y. and Ngan H.Y.S., Oncogenic microRNA signature for early diagnosis of cervical intraepithelial neoplasia and cancer, Mol Oncol.. 2018, 12: 2009-2022. |
| Ngu S.F., Chan K.K.L., Tse K.Y., Chu M.Y.M., Ip P.C.P., Cheung A.N.Y. and Ngan H.Y.S., Positive Surgical Margin At Cervical Conization For High-grade Squamous Intraepithelial Lesion: Does It Matter?, 17th Biennial Meeting of the International Gynecologic Cancer Society, Kyoto, Japan . 2018. |
| Siu K.Y., JIANG Y., WANG J., Han C.Y., Tsang B.K., Cheung A.N.Y., Ngan H.Y.S. and Chan K.K.L., Hexokinase 2 Regulates Ovarian Cancer Cell Migration, Invasion and Stemness via FAK/ERK1/2/MMP9/NANOG/SOX9 Signaling Cascades , Cancers. 2019, 11( 6 ): 813. |
| Sun J., Cai X., Yung M.H., Zhou W., Li J., Zhang Y., Li Z., Liu S., Cheung A.N.Y., Ngan H.Y.S., Li Y., Dai Z., Kai Y., Tzatsos A., Peng W., Chan D.W. and Zhu W., miR-137 mediates the functional link between c-Myc and EZH2 that regulates cisplatin resistance in ovarian cancer, Oncogene. 2019, 38: 564-580. |
| Tang K.S., Yue P.Y.K., Ip P.C.P., Huang R.L., Lai H.C., Cheung A.N.Y., Tse K.Y., Ngan H.Y.S. and Wong A.S.T., Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface, Nature Communications. 2018, 9: 2270. |
| Wong G.W., Cheung L.Y., Ip P.C.P., Ngan H.Y.S. and Cheung A.N.Y., Amyloid Precursor Protein Overexpression in Down Syndrome Trophoblast Reduces Cell Invasiveness and Interferes with Syncytialization., American Journal of Pathology. 2018, 188: 2307-2317. |
| Wong G.W., Tsun O.K.L., Tsui E.Y., Chow N.K., Ip P.C.P. and Cheung A.N.Y., HPV genotyping and E6/E7 transcript assays for cervical lesion detection in an Asian screening population—Cobas and Aptima HPV tests, Journal of Clinical Virology. 2018, 109: 13-18. |
| Wong G.W., Cheung L.Y., Liu S., Ngan H.Y.S. and Cheung A.N.Y., Multiple alterations on genes encoding components of the SWItch/Sucrose Non-Fermentable complex could be found in human papillomavirus-negative cervical cancer. , In: Wong OGW, Cheung CLY, Liu SS, Ngan HYS, Cheung AN., AACR New Horizons in Cancer Research Conference. May 3-5, 2019, Shenzhen, China.. 2019. |
| Wong T.L.I., Wong G.W. and Cheung A.N.Y., Nuclear PAK4 impairs homologous recombination via RAD51C to promote genome instability in high-grade serous ovarian cancer., In: Wong ITL, Wong OGW, Cheung AN., AACR New Horizons in Cancer Research Conference. May 3-5, 2019, Shenzhen, China.. 2019. |
| YU Y., Chow K.L., Lee H.Y.H., Cheuk W., Cheung E.T.Y., Chan W.K., Lee V.W.K., Cheung A.N.Y., Tse K.Y. and Ip P.C.P., Evaluation of potential immunotherapy biomarkers in female genital tract malignant melanomas, 108th Annual meeting of The United States and Canadian Academy of Pathology.. Modern Pathology, 2019, 134. |
| YU Y., Ip P.C.P. and Cheung A.N.Y., Molecular Mechanisms and Therapeutic Targets in Genital tract Malignant Melanomas, The University of Hong Kong. Hong Kong, The University of Hong Kong, 2018. |
| Researcher : Cheung LY |
| List of Research Outputs |
| Wong G.W., Cheung L.Y., Ip P.C.P., Ngan H.Y.S. and Cheung A.N.Y., Amyloid Precursor Protein Overexpression in Down Syndrome Trophoblast Reduces Cell Invasiveness and Interferes with Syncytialization., American Journal of Pathology. 2018, 188: 2307-2317. |
| Wong G.W., Cheung L.Y., Liu S., Ngan H.Y.S. and Cheung A.N.Y., Multiple alterations on genes encoding components of the SWItch/Sucrose Non-Fermentable complex could be found in human papillomavirus-negative cervical cancer. , In: Wong OGW, Cheung CLY, Liu SS, Ngan HYS, Cheung AN., AACR New Horizons in Cancer Research Conference. May 3-5, 2019, Shenzhen, China.. 2019. |
| Researcher : Cheung YN |
| Project Title: | AACR 101st Annual Meeting eIF4E in human breast cancer and its role in regulating translation of splice variants of breast cancer genes |
| Investigator(s): | Cheung YN |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2010 |
| Researcher : Chin WC |
| List of Research Outputs |
| Lee D., XU M., CHIU K.C., Leibold J., Tse P.W., Bao H.R., Yuen W.H., Chan Y.K., LAI K.H., Chin W.C., Chan F.F., Cheung T.T., Chok K.S.H., Wong C.M., Lowe S.W., Ng I.O.L. and Wong C.C.L., Induction of oxidative stress through inhibition of thioredoxin reductase 1 is an effective therapeutic approach for hepatocellular carcinoma, Hepatology. 2019, 69: 1768-1786. |
| Researcher : Ching YP |
| Project Title: | Roles of p21-activated protein kinase (Pak) 1 in the pathogenesis of liver cancer |
| Investigator(s): | Ching YP, Ng IOL, Jin D, Yau TO |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2006 |
| Project Title: | A study of the role of CDK5RAP3 in neuronal cell differentiation |
| Investigator(s): | Ching YP, Chang RCC |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2015 |
| Completion Date: | 12/2018 |
| Project Title: | Functional characterization of the roles of Polo-like kinase 4, Plk4 in hepatocarcinogenesis |
| Investigator(s): | Ching YP |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Project Title: | A study of the role of p21-activated kinase 4 (PAK4) in chromosome instability |
| Investigator(s): | Ching YP |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2017 |
| Completion Date: | 03/2019 |
| Project Title: | A study of the regulation of TAX1 binding protein 2 by p21-activated protein kinase 4 in liver cancer metastasis |
| Investigator(s): | Ching YP |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2017 |
| Project Title: | Characterization of the role of liver cancer stem cell marker, CD133 in promoting chromosome instability in hepatocarcinogenesis |
| Investigator(s): | Ching YP, Ma SKY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2018 |
| Project Title: | Molecular mechanisms of Pumilio-Regulated Chromosomal Instability in Hepatocellular Carcinoma |
| Investigator(s): | Ching YP |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2018 |
| Project Title: | Development of a P-21 activated protein kinase 4 specific inhibitory peptide as a novel hepatocellular carcinoma therapeutic agent |
| Investigator(s): | Ching YP |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 04/2019 |
| Project Title: | Regulation of a putative tumor suppressor, TAX1 binding protein 2 (TAX1BP2) by a centrosomal salt-inducible kinase |
| Investigator(s): | Ching YP |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2019 |
| Researcher : Chiu KC |
| Project Title: | Delineating the immunoregulatory role of PVRL1/TIGIT interaction in hepatocellular carcinoma and its resistance to PD-1 blockade |
| Investigator(s): | Chiu KC, Wong CCL |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2019 |
| Researcher : Choi WL |
| Project Title: | Correlation of the AML1-ETO isoform transcript levels with the prognosis of patients with acute myeloid leukemia (AML) with t(8;21) |
| Investigator(s): | Choi WL, Chan LC, So JCC, Ha SY, Leung AYH |
| Department: | Pathology |
| Source(s) of Funding: | Queen Mary Hospital Charitable Trust - Training and Research Assistance Scheme |
| Start Date: | 04/2011 |
| Researcher : Chow KL |
| List of Research Outputs |
| Ip P.C.P., Wang S.Y., Wong G.W., Chow K.L., Lee H.Y.H., Cheung A.N.Y. and Tse K.Y., Napsin A, Hepatocyte Nuclear Factor-1-Beta (HNF-1β), Estrogen and Progesterone Receptors Expression in Arias-Stella Reaction, The American Journal of Surgical Pathology. 2019, 43: 325-333. |
| YU Y., Chow K.L., Lee H.Y.H., Cheuk W., Cheung E.T.Y., Chan W.K., Lee V.W.K., Cheung A.N.Y., Tse K.Y. and Ip P.C.P., Evaluation of potential immunotherapy biomarkers in female genital tract malignant melanomas, 108th Annual meeting of The United States and Canadian Academy of Pathology.. Modern Pathology, 2019, 134. |
| Researcher : Chow NK |
| List of Research Outputs |
| Wong G.W., Tsun O.K.L., Tsui E.Y., Chow N.K., Ip P.C.P. and Cheung A.N.Y., HPV genotyping and E6/E7 transcript assays for cervical lesion detection in an Asian screening population—Cobas and Aptima HPV tests, Journal of Clinical Virology. 2018, 109: 13-18. |
| Researcher : Ding Q |
| List of Research Outputs |
| Zhao H., To K.K.W., Chu H., Ding Q., Zhao X., Li C., Shuai H.V., Yuan S., Zhou J., Kok K.H., Jiang S. and Yuen K.Y., Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza, Nature Communications. 2018, 9. |
| Researcher : Dong M |
| List of Research Outputs |
| SHI L., Tsoi H., Dong M., Man P.S. and Khoo U.S., Overexpression of BQ323636.1 modulated modulates tamoxifen resistance in ER positive breast cancer via IL-8-mediated signaling pathway., AACR Annual Meeting, Atlanta, March 29- April 3, 2019.. 2019. |
| Researcher : Ho DWH |
| Project Title: | Investigation of functional synergism of CENPF and FOXM1 in hepatocellular carcinoma |
| Investigator(s): | Ho DWH, Ng IOL, Chan LK, Kai AKL, Wong CCL |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2016 |
| Completion Date: | 01/2019 |
| Project Title: | High-dimensional analyses of TSC1/2 mutants in hepatocellular carcinoma: Gene expression landscapes and implication for mTOR inhibitor resistance |
| Investigator(s): | Ho DWH, Ng IOL, Chan LK |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research for Resubmission of GRF/ECS Proposals |
| Start Date: | 07/2018 |
| Completion Date: | 11/2018 |
| List of Research Outputs |
| Ho D.W.H., ELF4 co-operates with HBV DNA integration at the TERT promoter to enhance hepatocarcinogenesis, State Key Laboratory of Liver Research Symposium 2018. 2018. |
| Ho D.W.H., Tsui Y.M., Sze M.F., Chan L.K., Cheung T.T., Cheng L., Lee E., Wu A.R., Sham P.C., Tsui S.K.W., Lee T.K.W. and Ng I.O.L., Single-Cell Transcriptome Sequencing Reveals Intra-Tumor Heterogeneity and Rare Stemness-Related Cell Subpopulation in Hepatocellular Carcinoma, 12th Annual Conference of the International Liver Cancer Association. 2018. |
| Ho D.W.H., Tsui Y.M., Sze M.F., Chan L.K., Cheung T.T., Cheng L., Lee E., Wu A.R., Sham P.C., Tsui S.K., Lee T.K. and Ng I.O.L., Single-Cell Transcriptome Sequencing Reveals Intra-Tumor Heterogeneity and Rare Stemness-Related Cell Subpopulation in Hepatocellular Carcinoma, 9th Asia-Pacific Primary Liver Cancer Expert Meeting. 2018. |
| Ho D.W.H., Young Investigator Award, The 9th Asia-Pacific Primary Liver Cancer Expert Meeting. 2018. |
| Law C.T., Tsang F.H., Chan C.Y., XU M., Lai R.K., Ho D.W.H., Lee J.K.M., Wong C.C.L., Ng I.O.L. and Wong C.M., Chromatin remodeler HELLS is an epigenetic driver for hepatocellular carcinoma progression. , Hepatology . 2019. |
| Ma W., Ho D.W.H., Sze M.F., Tsui Y.M., Chan L.K., Lee E. and Ng I.O.L., APOBEC3B promotes hepatocarcinogenesis and metastasis through novel deaminase‐independent activity, Molecular Carcinogenesis. 2019, 58: 643-653. |
| TAN H.W., Leung C.O., Chan K.K., Ho D.W.H., Leung M.S., Wong C.M., Ng I.O.L. and Lo C.L.R., Deregulated GATA6 modulates stem cell-like properties and metabolic phenotype in hepatocellular carcinoma, Int J Cancer. 2019. |
| TAN H.W., LEUNG O.N., Chan K.S., Ho D.W.H., LEUNG M.S., Wong C.M., Ng I.O.L. and Lo C.L.R., Deregulated Gata6 Modulates Stem Cell‐like Properties And Metabolic Phenotype In Hepatocellular Carcinoma, International Journal Of Cancer. 2019, 145: 1860-1873. |
| Zhao L., Chan L.K., Ho D.W.H., Tsui Y.M., Sze M.F., Zhang X., Lee M.F. and Ng I.O.L., RalA is frequently up-regulated in human hepatocellular carcinoma and promotes metastasis and cancer stemness, AACR (American Association for Cancer Research) Annual Meeting 2018. |
| Researcher : Ho RSL |
| List of Research Outputs |
| Yan H.H.N., Siu H.C., Law S.Y.K., Ho R.S.L., Yue S.K.S., Tsui W.Y., Chan D., Chan A.S., Ma S.K.Y., Lam K.O., Bartfeld S., Man H.Y., Lee C.H., Chan A.S.Y., Wong W.H.J., Cheng S.W.P., Chan K.W., Zhang J., Shi J., Fan X., Kwong D.L.W., Mak T.W., Yuen S.T., Clevers H. and Leung S.Y., A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening, Cell Stem Cell. 2018. |
| Yan H.H.N., Chan D., Siu H.C., Law S.Y.K., Ho R.S.L., Tsui W.Y., Yue S.K.S., Chan A.S., Lee C.H., Chan A.S.Y., Chan K.W., Leung H.C., Hui H.S., Lam K.O., Kwong D.L.W., Mak T.W., Clevers H. and Leung S.Y., Establishment of a large-scale drug sensitivity screening platform on gastric cancer organoid cultures with potential to guide treatment. , American Association for Cancer Research (AACR) and Korean Cancer Association (KCA) Joint Conference on Precision Medicine in Solid Tumors. 2018. |
| Researcher : Hui HS |
| List of Research Outputs |
| Yan H.H.N., Chan D., Siu H.C., Law S.Y.K., Ho R.S.L., Tsui W.Y., Yue S.K.S., Chan A.S., Lee C.H., Chan A.S.Y., Chan K.W., Leung H.C., Hui H.S., Lam K.O., Kwong D.L.W., Mak T.W., Clevers H. and Leung S.Y., Establishment of a large-scale drug sensitivity screening platform on gastric cancer organoid cultures with potential to guide treatment. , American Association for Cancer Research (AACR) and Korean Cancer Association (KCA) Joint Conference on Precision Medicine in Solid Tumors. 2018. |
| Researcher : Ip HW |
| List of Research Outputs |
| Singh G.H.H., Ip H.W., Yim R.L.H., Tang W.F., Pang H.M.H., Lee P., Leung G.M.K., Li J.W.Y., Tang K., So J.C.C., Leung R.Y.Y., Li J., Panagiotou I., Lam C.C.K. and Kwong Y.L., Next-generation sequencing with a 54-gene panel identified unique mutational profile and prognostic markers in Chinese patients with myelofibrosis, Annals of Hematology. 2018. |
| Singh G.H.H., Kumana C.R., Yim R.L.H., Hwang Y.Y.G., Chan S.Y.T., Yip S.F., Lee H.K.K., Mak V., Lau J.S.M., Chan C.C., Kho B., Wong R.S.M., Li W., Lin S.Y., Lau C.K., Ip H.W., Leung R.Y.Y., Lam C.C.K. and Kwong Y.L., Oral arsenic trioxide incorporation into frontline treatment with all‐trans retinoic acid and chemotherapy in newly diagnosed acute promyelocytic leukemia: A 5‐year prospective study, Cancer. 2019. |
| Researcher : Ip PCP |
| Project Title: | Examining PD-L 1 status in genital tract melanomas |
| Investigator(s): | Ip PCP |
| Department: | Pathology |
| Source(s) of Funding: | Bristol-Myers Squibb Pharma (HK) Ltd. |
| Start Date: | 02/2017 |
| Project Title: | Pathogenetic mechanisms of female genital tract malignant melanoma |
| Investigator(s): | Ip PCP, Tsang TY |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2017 |
| Completion Date: | 10/2018 |
| Project Title: | 108th Annual Meeting of the United States and Canadian Academy of Pathology; Evaluation of potential immunotherapy biomarkers in female genital tract malignant melanomas/Evaluation of criteria for distinguishing uterine smooth muscle tumors of uncertain malignant potential (STUMP) from mimics and improved prediction of patient outcome: A multi-institutional study of 51 cases |
| Investigator(s): | Ip PCP |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2019 |
| Completion Date: | 03/2019 |
| Project Title: | Polo-like kinase 4 inhibitor effects and the double-strand DNA damage response (DDR) pathway in uterine leiomyosarcoma |
| Investigator(s): | Ip PCP, Lee HYH |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2019 |
| List of Research Outputs |
| Ip P.C.P., Wang Y. and Cheung A.N.Y., Complications of Early Pregnancy and Gestational Trophoblastic Diseases, In: Zheng WX, Fadare O, Quick CM, Shen DH, Guo DH, Gynecologic and Obstetric Pathology. Singapore, Springer, 2019, 2: 427-458. |
| Ip P.C.P., Editorial Board, In: Kari J. Syrjänen, Acta Cytologica. Karger, 2019. |
| Ip P.C.P., Editorial Board, In: Lora Hedrick Ellenson, M.D., International Journal of Gynaecological Pathology. USA, Lippincott Williams & Wilkins, 2019. |
| Ip P.C.P., Ordulu Z., Lim D., Soslow R., Young R.H., Jia L.W., Chiang S. and Oliva E., Evaluation of criteria for distinguishing uterine smooth muscle tumors of uncertain malignant potential (STUMP) from mimics and improved prediction of patient outcome: A multi-institutional study of 51 cases, 108th Annual meeting of The United States and Canadian Academy of Pathology. Modern Pathology, 2019, 32: 49. |
| Ip P.C.P., Wang S.Y., Wong G.W., Chow K.L., Lee H.Y.H., Cheung A.N.Y. and Tse K.Y., Napsin A, Hepatocyte Nuclear Factor-1-Beta (HNF-1β), Estrogen and Progesterone Receptors Expression in Arias-Stella Reaction, The American Journal of Surgical Pathology. 2019, 43: 325-333. |
| Li S., Ip K.M., Tang Y.H., Tang K.S., Tong Y., Zhang J., Hassan A.A., Mak A.S.C., Yung S.S.Y., Chan D.T.M., Ip P.C.P., Lee C.L., Chiu C.N., Lee L.T.O., Lai H.C., Zeng J.Z., Shum H.C. and Wong A.S.T., Sialyl LewisX-P-selectin cascade mediates tumor-mesothelial adhesion in ascitic fluid shear flow, Nat Cummun. 2019, 10(1): 2406. |
| Liu S., Chan K.K.L., Chu K.H., Wei N., Lau S.K., Ngu S.F., Chu M.Y.M., Tse K.Y., Ip P.C.P., Ng E.K.O., Cheung A.N.Y. and Ngan H.Y.S., Oncogenic microRNA signature for early diagnosis of cervical intraepithelial neoplasia and cancer, Mol Oncol.. 2018, 12: 2009-2022. |
| Ngu S.F., Chan K.K.L., Tse K.Y., Chu M.Y.M., Ip P.C.P., Cheung A.N.Y. and Ngan H.Y.S., Positive Surgical Margin At Cervical Conization For High-grade Squamous Intraepithelial Lesion: Does It Matter?, 17th Biennial Meeting of the International Gynecologic Cancer Society, Kyoto, Japan . 2018. |
| Tang K.S., Yue P.Y.K., Ip P.C.P., Huang R.L., Lai H.C., Cheung A.N.Y., Tse K.Y., Ngan H.Y.S. and Wong A.S.T., Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface, Nature Communications. 2018, 9: 2270. |
| Wong G.W., Cheung L.Y., Ip P.C.P., Ngan H.Y.S. and Cheung A.N.Y., Amyloid Precursor Protein Overexpression in Down Syndrome Trophoblast Reduces Cell Invasiveness and Interferes with Syncytialization., American Journal of Pathology. 2018, 188: 2307-2317. |
| Wong G.W., Tsun O.K.L., Tsui E.Y., Chow N.K., Ip P.C.P. and Cheung A.N.Y., HPV genotyping and E6/E7 transcript assays for cervical lesion detection in an Asian screening population—Cobas and Aptima HPV tests, Journal of Clinical Virology. 2018, 109: 13-18. |
| YU Y., Chow K.L., Lee H.Y.H., Cheuk W., Cheung E.T.Y., Chan W.K., Lee V.W.K., Cheung A.N.Y., Tse K.Y. and Ip P.C.P., Evaluation of potential immunotherapy biomarkers in female genital tract malignant melanomas, 108th Annual meeting of The United States and Canadian Academy of Pathology.. Modern Pathology, 2019, 134. |
| YU Y., Ip P.C.P. and Cheung A.N.Y., Molecular Mechanisms and Therapeutic Targets in Genital tract Malignant Melanomas, The University of Hong Kong. Hong Kong, The University of Hong Kong, 2018. |
| Researcher : Ip PPC |
| Project Title: | Examining PD-L 1 status in genital tract melanomas |
| Investigator(s): | Ip PCP |
| Department: | Pathology |
| Source(s) of Funding: | Bristol-Myers Squibb Pharma (HK) Ltd. |
| Start Date: | 02/2017 |
| Project Title: | Pathogenetic mechanisms of female genital tract malignant melanoma |
| Investigator(s): | Ip PCP, Tsang TY |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2017 |
| Completion Date: | 10/2018 |
| Project Title: | 108th Annual Meeting of the United States and Canadian Academy of Pathology; Evaluation of potential immunotherapy biomarkers in female genital tract malignant melanomas/Evaluation of criteria for distinguishing uterine smooth muscle tumors of uncertain malignant potential (STUMP) from mimics and improved prediction of patient outcome: A multi-institutional study of 51 cases |
| Investigator(s): | Ip PCP |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2019 |
| Completion Date: | 03/2019 |
| Project Title: | Polo-like kinase 4 inhibitor effects and the double-strand DNA damage response (DDR) pathway in uterine leiomyosarcoma |
| Investigator(s): | Ip PCP, Lee HYH |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2019 |
| List of Research Outputs |
| Researcher : KWOK SYJ |
| List of Research Outputs |
| KWOK S.Y.J., Guo M., Yang W., Ip P., LEE C.K., Lu L., Chan G.C.F., Middleton D. and van der Zanden H.G.M., Simulation of non-inherited maternal antigens acceptable HLA mismatches to increase the chance of matched cord blood units: Hong Kong’s experience, Human Immunology. 2018, 79: 539-544. |
| Researcher : Khoo US |
| Project Title: | Association of the pro-inflammatory and anti-inflammatory cytokine gene polymorphism to breast cancer susceptibility |
| Investigator(s): | Khoo US, Cheung ANY, Chan YK |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Project Title: | Infectious Diseases and Global Health: Genetic approach to the identification of host susceptibility factors and pathogen virulence determinants. Genetics of coronaviruses-associated acute respiratory disease |
| Investigator(s): | Khoo US |
| Department: | Pathology |
| Source(s) of Funding: | CGDN NCE Large Scale Collaborative Research Grant |
| Start Date: | 02/2005 |
| Project Title: | HER2 Dual ISH test to assess eligibility for Trastuzumab (Herceptin) in breast cancer patients receiving treatment from public hospitals |
| Investigator(s): | Khoo US, Leung TW, Luk MY, Yeung MWR |
| Department: | Pathology |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 11/2013 |
| Project Title: | Testing Ivabradine on Patient Derived Xenografts: A Novel Potential Targeted Treatment for Breast Cancer |
| Investigator(s): | Khoo US, Tsoi H, Kwong A, Siu DCW |
| Department: | Pathology |
| Source(s) of Funding: | Innovation and Technology Support Programme (Tier 3) |
| Start Date: | 02/2017 |
| Project Title: | Testing Ivabradine On Patient Derived Xenografts: A Novel Potential Targeted Treatment For Breast Cancer |
| Investigator(s): | Khoo US, Tsoi H, Kwong A |
| Department: | Pathology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 02/2017 |
| Project Title: | Identifying Splicosome gene alterations associated with Tamoxifen resistance in Breast Cancer |
| Investigator(s): | Khoo US |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2017 |
| Project Title: | Hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) regulating apoptosis resistance, autophagy and cellular senescence in breast cancer: a novel potential anti-cancer target. |
| Investigator(s): | Khoo US, Tsoi H |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2017 |
| Project Title: | Testing Ivabradine On Patient Derived Xenografts: A Novel Potential Targeted Treatment For Breast Cancer |
| Investigator(s): | Khoo US, Tsoi H, Kwong A, Siu DCW |
| Department: | Pathology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 01/2018 |
| Project Title: | The feasibility of using BQ323636.1, a novel splice variant of NCOR2, as a biomarker for predicting treatment response of aromatase inhibitor in ER+ve breast cancer patients |
| Investigator(s): | Khoo US, Tsoi H |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 04/2018 |
| Project Title: | Identifying interacting proteins to BQ, a novel splice variant of NCOR2 that could modulate its competition with NCOR2 in Androgen-receptor positive breast cancer |
| Investigator(s): | Khoo US, Tsoi H |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2018 |
| Project Title: | Molecular Targets and Cancer Therapeutics; Hyperpolarization-activated cyclic nucleotide-gated channel (HCN) blocker, Ivabradine, a novel potential targeted treatment for triple-negative breast cancer |
| Investigator(s): | Khoo US |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2018 |
| Completion Date: | 11/2018 |
| Project Title: | The molecular mechanism controlling the synthesis of novel splice variant BQ323636.1 and its contribution to drug resistant breast cancer. |
| Investigator(s): | Khoo US, Tsoi H |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2019 |
| Project Title: | Identification of exosome biomarkers to predict tamoxifen resistance in ER+ve/BQ+ve breast cancer patients |
| Investigator(s): | Khoo US, Tsoi H |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 05/2019 |
| List of Research Outputs |
| Khoo U.S., MOK K.C., Man P.S., Chau K.M., Lee T.K. and Gong C., Hyperpolarization-activated cyclic nucleotide-gated channel (HCN) blocker, Ivabradine, a novel potential targeted treatment for triple-negative breast cancer., 30th EORTC-NCI-AACR Symposium, Dublin, Ireland. 13-16 November 2018.. 2018. |
| Khoo U.S., Pathology Education in Hong Kong: Its Evolution in 100 Years, Pathology 100th Anniversary & 7th Hong Kong Pathology Forum, Hong Kong. 2019. |
| Khoo U.S., The NCOR2 Splice Variant as Genomic Biomarker for Breast Cancer, Pathology 100th Anniversary & 7th Hong Kong Pathology Forum. 2019. |
| SHI L., Tsoi H., Dong M., Man P.S. and Khoo U.S., Overexpression of BQ323636.1 modulated modulates tamoxifen resistance in ER positive breast cancer via IL-8-mediated signaling pathway., AACR Annual Meeting, Atlanta, March 29- April 3, 2019.. 2019. |
| Researcher : Ko FCF |
| Project Title: | Unravel the RhoGAP independent pathway of Deleted in Liver Cancer 1 tumor suppressor |
| Investigator(s): | Ko FCF, Yam JWP |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2012 |
| List of Research Outputs |
| Mao X., Tey S.K., Ko F.C.F., Kwong M.L., Goa Y., Ng I.O.L., Cheung S.T., Guan X. and Yam J.W.P., C-terminal truncated HBx protein activates caveolin-1/LRP6/β-catenin/FRMD5 axis in promoting hepatocarcinogenesis, Cancer Letters. 2019, 444: 60-69. |
| Mao X., Ko F.C.F., Tey S.K., Man K., Lo C.L.R., Ng I.O.L. and Yam J.W.P., Hypoxia-induced caveolin-1 drives tumorigenesis and metastasis by activation of NF-κB/S100P pathway in hepatocellular carcinoma, Health Research Symposium 2019. |
| Researcher : Kwok JSY |
| List of Research Outputs |
| Kwok J.S.Y., Chu P., Ong C.Y.T., Law K., Ip P., Chan G.C.F. and Lu L., Role of Regulatory T Cells in Noninherited Maternal Antigen-Related Tolerance in Cord Blood: An in Vitro Study, Biology of Blood and Marrow Transplantation. 2019, 25: 424-435. |
| Researcher : Kwong ML |
| List of Research Outputs |
| Mao X., Tey S.K., Ko F.C.F., Kwong M.L., Goa Y., Ng I.O.L., Cheung S.T., Guan X. and Yam J.W.P., C-terminal truncated HBx protein activates caveolin-1/LRP6/β-catenin/FRMD5 axis in promoting hepatocarcinogenesis, Cancer Letters. 2019, 444: 60-69. |
| Researcher : LAI KH |
| List of Research Outputs |
| Lee D., XU M., CHIU K.C., Leibold J., Tse P.W., Bao H.R., Yuen W.H., Chan Y.K., LAI K.H., Chin W.C., Chan F.F., Cheung T.T., Chok K.S.H., Wong C.M., Lowe S.W., Ng I.O.L. and Wong C.C.L., Induction of oxidative stress through inhibition of thioredoxin reductase 1 is an effective therapeutic approach for hepatocellular carcinoma, Hepatology. 2019, 69: 1768-1786. |
| Researcher : LAW CT |
| List of Research Outputs |
| Law C.T., Tsang F.H., Chan C.Y., XU M., Lai R.K., Ho D.W.H., Lee J.K.M., Wong C.C.L., Ng I.O.L. and Wong C.M., Chromatin remodeler HELLS is an epigenetic driver for hepatocellular carcinoma progression. , Hepatology . 2019. |
| Tsang F.H., LAW C.T., Tang T.C.C., Cheng C.L., Chin D.W., Tam W.S.V., Wei L., Wong C.C.L., Ng I.O.L. and Wong C.M., Aberrant super-enhancer landscape in human hepatocellular carcinoma, Hepatology. 2019. |
| Researcher : LEUNG MS |
| List of Research Outputs |
| TAN H.W., Leung C.O., Chan K.K., Ho D.W.H., Leung M.S., Wong C.M., Ng I.O.L. and Lo C.L.R., Deregulated GATA6 modulates stem cell-like properties and metabolic phenotype in hepatocellular carcinoma, Int J Cancer. 2019. |
| TAN H.W., LEUNG O.N., Chan K.S., Ho D.W.H., LEUNG M.S., Wong C.M., Ng I.O.L. and Lo C.L.R., Deregulated Gata6 Modulates Stem Cell‐like Properties And Metabolic Phenotype In Hepatocellular Carcinoma, International Journal Of Cancer. 2019, 145: 1860-1873. |
| Researcher : Lai JCC |
| List of Research Outputs |
| Lai J.C.C., HERATH MUDIYANSELAGE T.K.K..., Wong H.H., Peiris J.S.M. and Nicholls J.M., Neuraminidase activity and specificity of influenza A virus are influenced by haemagglutinin-receptor binding, Emerging Microbes & Infections. 2019, 8(1): 327-338. |
| Researcher : Lam CCK |
| List of Research Outputs |
| Singh G.H.H., Ip H.W., Yim R.L.H., Tang W.F., Pang H.M.H., Lee P., Leung G.M.K., Li J.W.Y., Tang K., So J.C.C., Leung R.Y.Y., Li J., Panagiotou I., Lam C.C.K. and Kwong Y.L., Next-generation sequencing with a 54-gene panel identified unique mutational profile and prognostic markers in Chinese patients with myelofibrosis, Annals of Hematology. 2018. |
| Singh G.H.H., Kumana C.R., Yim R.L.H., Hwang Y.Y.G., Chan S.Y.T., Yip S.F., Lee H.K.K., Mak V., Lau J.S.M., Chan C.C., Kho B., Wong R.S.M., Li W., Lin S.Y., Lau C.K., Ip H.W., Leung R.Y.Y., Lam C.C.K. and Kwong Y.L., Oral arsenic trioxide incorporation into frontline treatment with all‐trans retinoic acid and chemotherapy in newly diagnosed acute promyelocytic leukemia: A 5‐year prospective study, Cancer. 2019. |
| Researcher : Lam CW |
| Project Title: | Food |
| Investigator(s): | Lam CW, Wang M |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 09/2013 |
| Project Title: | Regulatory signatures of two novel prognostic metabotypes of lung adenocarcinomas: integrated analysis of transcriptomics and metabonomics of malignant pleural effusions |
| Investigator(s): | Lam CW |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2016 |
| Project Title: | Clinical application of pleural fluid fatty acid synthase and pleural fluid total free fatty acids as cancer biomarkers in malignant pleural effusions |
| Investigator(s): | Lam CW |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Mini Grant |
| Start Date: | 06/2017 |
| Completion Date: | 08/2019 |
| Project Title: | The chemokine and cytokine network and signature of a novel prognostic immune-metabotype of lung adenocarcinomas: a proteo-metabonomic study of malignant pleural effusions |
| Investigator(s): | Lam CW, Yam JWP |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2019 |
| List of Research Outputs |
| CHENG Y.H., TAM S.C.T., Chau S.L., LAI K.M., Tang H.W., Lok C.N., Lam C.W. and Ng K.M., Plasmonic gold nanoparticles as multifaceted probe for tissue imaging, In: Cheng YH, Tam TS , Chau SL , Lai SK , Tang HW , Lok CN , Lam CW , Ng KM , Chemical Communications. 2019, 55: 2761-2764. |
| Lam C.W., (1) Whole-exome sequencing of quartet family identifies a novel gene for mitochondrial DNA depletion syndrome (2) An undiagnosed diseases program in Hong Kong, China, 63rd Annual Meeting of the Japan Society of Human Genetics (JSHG2018) , October 10-13, 2018, Yokohama, Japan. 2018. |
| Lam K.O., Tong C.C., Lee V.H.F., Luk M.Y. and Lam C.W., DPYD genotype-guided dose individualisation of fluoropyrimidine therapy: who and how?, The Lancet Oncology. 2019, 20: e66. |
| Researcher : Lee CH |
| List of Research Outputs |
| Yan H.H.N., Siu H.C., Law S.Y.K., Ho R.S.L., Yue S.K.S., Tsui W.Y., Chan D., Chan A.S., Ma S.K.Y., Lam K.O., Bartfeld S., Man H.Y., Lee C.H., Chan A.S.Y., Wong W.H.J., Cheng S.W.P., Chan K.W., Zhang J., Shi J., Fan X., Kwong D.L.W., Mak T.W., Yuen S.T., Clevers H. and Leung S.Y., A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening, Cell Stem Cell. 2018. |
| Yan H.H.N., Chan D., Siu H.C., Law S.Y.K., Ho R.S.L., Tsui W.Y., Yue S.K.S., Chan A.S., Lee C.H., Chan A.S.Y., Chan K.W., Leung H.C., Hui H.S., Lam K.O., Kwong D.L.W., Mak T.W., Clevers H. and Leung S.Y., Establishment of a large-scale drug sensitivity screening platform on gastric cancer organoid cultures with potential to guide treatment. , American Association for Cancer Research (AACR) and Korean Cancer Association (KCA) Joint Conference on Precision Medicine in Solid Tumors. 2018. |
| Researcher : Lee D |
| List of Research Outputs |
| Lee D., XU M., CHIU K.C., Leibold J., Tse P.W., Bao H.R., Yuen W.H., Chan Y.K., LAI K.H., Chin W.C., Chan F.F., Cheung T.T., Chok K.S.H., Wong C.M., Lowe S.W., Ng I.O.L. and Wong C.C.L., Induction of oxidative stress through inhibition of thioredoxin reductase 1 is an effective therapeutic approach for hepatocellular carcinoma, Hepatology. 2019, 69: 1768-1786. |
| Researcher : Lee E |
| List of Research Outputs |
| Ho D.W.H., Tsui Y.M., Sze M.F., Chan L.K., Cheung T.T., Cheng L., Lee E., Wu A.R., Sham P.C., Tsui S.K.W., Lee T.K.W. and Ng I.O.L., Single-Cell Transcriptome Sequencing Reveals Intra-Tumor Heterogeneity and Rare Stemness-Related Cell Subpopulation in Hepatocellular Carcinoma, 12th Annual Conference of the International Liver Cancer Association. 2018. |
| Ho D.W.H., Tsui Y.M., Sze M.F., Chan L.K., Cheung T.T., Cheng L., Lee E., Wu A.R., Sham P.C., Tsui S.K., Lee T.K. and Ng I.O.L., Single-Cell Transcriptome Sequencing Reveals Intra-Tumor Heterogeneity and Rare Stemness-Related Cell Subpopulation in Hepatocellular Carcinoma, 9th Asia-Pacific Primary Liver Cancer Expert Meeting. 2018. |
| Ma W., Ho D.W.H., Sze M.F., Tsui Y.M., Chan L.K., Lee E. and Ng I.O.L., APOBEC3B promotes hepatocarcinogenesis and metastasis through novel deaminase‐independent activity, Molecular Carcinogenesis. 2019, 58: 643-653. |
| Researcher : Lee HYH |
| List of Research Outputs |
| Ip P.C.P., Wang S.Y., Wong G.W., Chow K.L., Lee H.Y.H., Cheung A.N.Y. and Tse K.Y., Napsin A, Hepatocyte Nuclear Factor-1-Beta (HNF-1β), Estrogen and Progesterone Receptors Expression in Arias-Stella Reaction, The American Journal of Surgical Pathology. 2019, 43: 325-333. |
| YU Y., Chow K.L., Lee H.Y.H., Cheuk W., Cheung E.T.Y., Chan W.K., Lee V.W.K., Cheung A.N.Y., Tse K.Y. and Ip P.C.P., Evaluation of potential immunotherapy biomarkers in female genital tract malignant melanomas, 108th Annual meeting of The United States and Canadian Academy of Pathology.. Modern Pathology, 2019, 134. |
| Researcher : Lee JKM |
| List of Research Outputs |
| Law C.T., Tsang F.H., Chan C.Y., XU M., Lai R.K., Ho D.W.H., Lee J.K.M., Wong C.C.L., Ng I.O.L. and Wong C.M., Chromatin remodeler HELLS is an epigenetic driver for hepatocellular carcinoma progression. , Hepatology . 2019. |
| Researcher : Lee KW |
| Project Title: | The role of cathepsin S (CTSS) and efficacy of CTSS targeted therapy in CD47+ tumor initiating cells-driven hepatocellular carcinoma |
| Investigator(s): | Lee KW, Ng IOL, Ma SKY |
| Department: | Pathology |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2013 |
| Project Title: | The roles of Nuclear factor (erythroid-derived 2)-like 2 in hepatocellular carcinoma |
| Investigator(s): | Lee KW |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2015 |
| Researcher : Lee MF |
| List of Research Outputs |
| Zhao L., Chan L.K., Ho D.W.H., Tsui Y.M., Sze M.F., Zhang X., Lee M.F. and Ng I.O.L., RalA is frequently up-regulated in human hepatocellular carcinoma and promotes metastasis and cancer stemness, AACR (American Association for Cancer Research) Annual Meeting 2018. |
| Researcher : Leung HC |
| List of Research Outputs |
| Yan H.H.N., Chan D., Siu H.C., Law S.Y.K., Ho R.S.L., Tsui W.Y., Yue S.K.S., Chan A.S., Lee C.H., Chan A.S.Y., Chan K.W., Leung H.C., Hui H.S., Lam K.O., Kwong D.L.W., Mak T.W., Clevers H. and Leung S.Y., Establishment of a large-scale drug sensitivity screening platform on gastric cancer organoid cultures with potential to guide treatment. , American Association for Cancer Research (AACR) and Korean Cancer Association (KCA) Joint Conference on Precision Medicine in Solid Tumors. 2018. |
| Researcher : Leung MS |
| List of Research Outputs |
| TAN H.W., Leung C.O., Chan K.K., Ho D.W.H., Leung M.S., Wong C.M., Ng I.O.L. and Lo C.L.R., Deregulated GATA6 modulates stem cell-like properties and metabolic phenotype in hepatocellular carcinoma, Int J Cancer. 2019. |
| TAN H.W., LEUNG O.N., Chan K.S., Ho D.W.H., LEUNG M.S., Wong C.M., Ng I.O.L. and Lo C.L.R., Deregulated Gata6 Modulates Stem Cell‐like Properties And Metabolic Phenotype In Hepatocellular Carcinoma, International Journal Of Cancer. 2019, 145: 1860-1873. |
| Researcher : Leung RYY |
| List of Research Outputs |
| Singh G.H.H., Ip H.W., Yim R.L.H., Tang W.F., Pang H.M.H., Lee P., Leung G.M.K., Li J.W.Y., Tang K., So J.C.C., Leung R.Y.Y., Li J., Panagiotou I., Lam C.C.K. and Kwong Y.L., Next-generation sequencing with a 54-gene panel identified unique mutational profile and prognostic markers in Chinese patients with myelofibrosis, Annals of Hematology. 2018. |
| Singh G.H.H., Kumana C.R., Yim R.L.H., Hwang Y.Y.G., Chan S.Y.T., Yip S.F., Lee H.K.K., Mak V., Lau J.S.M., Chan C.C., Kho B., Wong R.S.M., Li W., Lin S.Y., Lau C.K., Ip H.W., Leung R.Y.Y., Lam C.C.K. and Kwong Y.L., Oral arsenic trioxide incorporation into frontline treatment with all‐trans retinoic acid and chemotherapy in newly diagnosed acute promyelocytic leukemia: A 5‐year prospective study, Cancer. 2019. |
| Researcher : Leung SY |
| Project Title: | Identification of BRAF mutation in various stages of colorectal carcinogenesis and its relationship with KRAS mutation |
| Investigator(s): | Leung SY, Yuen ST |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2002 |
| Project Title: | Detail study of relationship of BRAF and KRAS mutation with microstatellite instability in colorectal cancer |
| Investigator(s): | Leung SY, Yuen ST |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Project Title: | Genomic screening for potential tumour suppressors silenced by promoter hypermethylation in gastric adenocarcinomas using cDNA microarray |
| Investigator(s): | Leung SY, Yuen ST, Chu KM, Fung TWK, Lin MC |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2005 |
| Project Title: | Outstanding Researcher Award 2006-2007 |
| Investigator(s): | Leung SY |
| Department: | Pathology |
| Source(s) of Funding: | Outstanding Researcher Award |
| Start Date: | 11/2007 |
| Project Title: | Research Output Prize (Faculty of Medicine) |
| Investigator(s): | Leung SY |
| Department: | Pathology |
| Source(s) of Funding: | Research Output Prize (in Faculty) |
| Start Date: | 11/2007 |
| Project Title: | Research Output Prize |
| Investigator(s): | Leung SY, Chan TL |
| Department: | Pathology |
| Source(s) of Funding: | Research Output Prize (in Faculty) |
| Start Date: | 12/2009 |
| Project Title: | Gastric Cancer Genomics and Beyond – Moving from Patient Samples to 3D Organoid Cultures for Integrative Genomics Analysis, Drug Sensitivity Assays, Cell Biological Studies and Animal Models |
| Investigator(s): | Leung SY, Zhang J, Law SYK, Ma SKY, Kwong DLW, Chan D, Ching YP, Wong SL |
| Department: | Pathology |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 11/2016 |
| Project Title: | Establishing Mass Spectrometer Based Targeted Metobolomics Platform for Biomarker Validation Studies as a Core Facility |
| Investigator(s): | Leung SY, Boheler KR, Cheung BMY, Cheung CL, Leung AYH, Ma SKY, Rong J, Sze KH, Woo PCY, Wong CCL, Xu A |
| Department: | Pathology |
| Source(s) of Funding: | Small Equipment Grant |
| Start Date: | 06/2017 |
| Project Title: | Differential topological accumulation of somatic mutations in normal and cancerous gastric stem cells, and their association with gastric carcinogenesis and anti-tumour immuse response |
| Investigator(s): | Leung SY, Yan HHN |
| Department: | Pathology |
| Source(s) of Funding: | Kadoorie Charitable Foundation |
| Start Date: | 03/2018 |
| List of Research Outputs |
| CHAN L.H., Zhou L., Ng K.Y., Wong T.L., Lee T.K., Sharma R., LOONG H.C., Ching Y.P., Yuan Y.F., Xie D., Lo C.M., Man K., Artegiani B., Clevers H., Yan H.H.N., Leung S.Y., Richard S., Guan X., Huen M.S.Y. and Ma S.K.Y., Protein arginine methyltransferase PRMT6 regulates RAS/RAF binding and MEK/ERK-mediated cancer stemness activities in hepatocellular carcinoma through CRAF methylation, Cell Reports. 2018. |
| Chan A.S., Yan H.H.N. and Leung S.Y., Breakthrough Moments: Organoid Models of Cancer, Cell Stem Cell. 2019, 24: 839-840. |
| Leung S.Y., A comprehensive human gastric cancer organoid biobank that captures molecular diversity and heterogeneity and enable therapeutic screening, AACR International Conference New Horizons in Cancer Research, Shenzhen, China. 2019. |
| Leung S.Y., Building a gastric cancer organoid biobank for the development of precision oncology, Yonsei Gastri Cancer Symposium, Seoul, Korea. 2019. |
| Leung S.Y., Gastric Cancer – Linking Pathology, Genomics and Organoid-based drug Screening for Precision Oncology, Hong Kong Pathology Forum 2019, Department of Pathology, The University of Hong Kong. 2019. |
| Leung S.Y., Gastric cancer organoid culture – comprehensive molecular subtypes that enables large scale therapeutic screening, Korea International Gastric Cancer Week 2019, Incheon, Korea. 2019. |
| Leung S.Y., Gastric cancer – linking pathology, genomics and organoid-based drug screening for precision oncology, Nature Conference – Genome Varitation in Precision Medicine, Nanjing, China. 2019. |
| Leung S.Y., Genomic Study on Molecular Pathways of Cancer Development and its Relevance to Cancer Precision Medicine, Health Research Symposium, Hong Kong. 2019. |
| Leung S.Y., Genomic analysis coupled with cancer organoid culture technology - building of next generation cancer cell models for therapeutic development, Hong Kong Hospital Authority Convention 2019, Hong Kong. 2019. |
| Leung S.Y., Lynch Syndrome and its Clinical Relevance in Gynaecological Cancer, The Obstetrical and Gynaecological Society of Hong Kong Annual Scientific Meeting 2019, Hong Kong. 2019. |
| Leung S.Y., Polyps of the gastrointestinal tract – morphological classification, genetics and therapeutic implications, HKIAP Spring Scientific Meeting, Hong Kong. 2019. |
| Leung S.Y., Research Insights and Clinical Applications of Human Gastric Cancer Organoid Biobanking, Digestive Disease Week 2019, San Diego, USA. 2019. |
| TONG Y., SUN J., WONG C.F., KANG Q., RU B., WONG C., Chan A.S., Leung S.Y. and Zhang J., MICMIC: identification of DNA methylation of distal regulatory regions with causal effects on tumorigenesis, Genome Biology. 2018, 19. |
| Yan H.H.N., Siu H.C., Law S.Y.K., Ho R.S.L., Yue S.K.S., Tsui W.Y., Chan D., Chan A.S., Ma S.K.Y., Lam K.O., Bartfeld S., Man H.Y., Lee C.H., Chan A.S.Y., Wong W.H.J., Cheng S.W.P., Chan K.W., Zhang J., Shi J., Fan X., Kwong D.L.W., Mak T.W., Yuen S.T., Clevers H. and Leung S.Y., A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening, Cell Stem Cell. 2018. |
| Researcher : Lin X |
| Project Title: | IMMUNOLOGY 2015™ AAI Annual Meeting; A Critical Role of Th17 Cells in the Development of Murine Sjogeren’s Syndrome |
| Investigator(s): | Lin X |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2015 |
| List of Research Outputs |
| Guggino G., Lin X., Rizzo A., Xiao F., Saieva L., Raimondo S., Di Liberto D., Candore G., Ruscitti P., Cipriani P., Giacomelli R., Dieli F., Alessandro R., Triolo G., Lu L. and Ciccia F., Interleukin-25 Axis Is Involved in the Pathogenesis of Human Primary and Experimental Murine Sjögren's Syndrome, Arthritis & Rheumatology. 2018, 70: 1265-1275. |
| Lin X. and Lu L., Best Poster Presentation Award, 2018, Hong Kong Society for Immunology. 2018. |
| Lin X., Wang X., Xiao F., Ma K., Liu L., Wang X., Xu D., Wang F., Shi X., Liu D., Zhao Y. and Lu L., IL-10-producing regulatory B cells restrain the T follicular helper cell response in primary Sjögren’s syndrome, Cellular & Molecular Immunology. 2019. |
| Tian J., Rui K., Hong Y., Wang X., Xiao F., Lin X., Ma J., Guo H., Xu H., Ma K., Xu D., Liu D., Zhao Y., Lu L. and Wang S., Increased GITRL Impairs the Function of Myeloid-Derived Suppressor Cells and Exacerbates Primary Sjögren Syndrome, The Journal of Immunology. 2019, 202: 1693-1703. |
| Wang X., Cong Y., Lin X., Ma K., Xiao F., Dong L. and Lu L., New insights into the significance of the BCR repertoire in B-1 cell development and function, Cellular & Molecular Immunology. 2019. |
| Researcher : Liu J |
| Project Title: | Targeting lactate dehydrogenase A for extranodal NK/T-cell lymphoma therapy |
| Investigator(s): | Liu J, Au Yeung KHR, Tse EWC |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2019 |
| Researcher : Lo CLR |
| Project Title: | Study of the clinical relevance and functional role of Stanniocalcin 1 in hepatocellular carcinoma |
| Investigator(s): | Lo CLR, Wong CCL |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2016 |
| Completion Date: | 02/2019 |
| Project Title: | Clinical relevance and functional characterization of Cripto-1 in conferring stemness properties of hepatocellular carcinoma |
| Investigator(s): | Lo CLR, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2016 |
| Project Title: | Delineation and validation of downstream targets of GATA6 in conferring stemness features of liver cancer |
| Investigator(s): | Lo CLR |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| Completion Date: | 05/2019 |
| Project Title: | The role of STC1 in liver fibrosis - a pilot study |
| Investigator(s): | Lo CLR |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2018 |
| Project Title: | Study of the efficacy of PIM inhibitors in hepatocellular carcinoma |
| Investigator(s): | Lo CLR, Wong CCL, Kao WJ |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2018 |
| Project Title: | AASLD ANNUAL MEETING 2018; DEREGULATION OF GATA6 DEFINES STEM CELL-LIKE PROPERTIES IN HEPATOCELLULAR CARCINOMA |
| Investigator(s): | Lo CLR |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2018 |
| Completion Date: | 11/2018 |
| Project Title: | The clinical and functional significance of Sox9/sCLU in liver cancer |
| Investigator(s): | Lo CLR |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2019 |
| Project Title: | Targeting Cripto-1 in liver cancer with aptamer-conjugated and cholesterol-conjugated antisense oligonucleotide delivery systems |
| Investigator(s): | Lo CLR |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 06/2019 |
| List of Research Outputs |
| Fung J.Y.Y., Wong D.K.H., Tanaka Y., Lo C.L.R., Wong C.L.T., Chok K.S.H., Chan A.C.Y., Cheung T.T., Dai W.C., Ng K.C.K., Ng K.T.P., Man K., Ng I.O.L., Seto W.K.W., Lai C.L., Yuen R.M.F. and Lo C.M., Quantitative hepatitis B surface antigen in predicting recurrence of hepatitis B-related hepatocellular carcinoma after liver transplantation, Hepatoma Research. 2018, 4: 62. |
| Liu A.P.Y., Ip J.K.J., Leung A.W.K., Luk C.W., Li C.H., Ho K.K.H., Lo C.L.R., Chan E.K.W., Chan A.C.Y., Chung H.Y. and Chiang A.K.S., Treatment outcome and pattern of failure in hepatoblastoma treated with a consensus protocol in Hong Kong, Pediatric Blood & Cancer. 2018, 66(1): e27482. |
| Mao X., Ko F.C.F., Tey S.K., Man K., Lo C.L.R., Ng I.O.L. and Yam J.W.P., Hypoxia-induced caveolin-1 drives tumorigenesis and metastasis by activation of NF-κB/S100P pathway in hepatocellular carcinoma, Health Research Symposium 2019. |
| Ng I.O.L. and Lo C.L.R., Faculty Outstanding Research Output Award, LKS Faculty of Medicine, HKU. 2018. |
| TAN H.W., Leung C.O., Chan K.K., Ho D.W.H., Leung M.S., Wong C.M., Ng I.O.L. and Lo C.L.R., Deregulated GATA6 modulates stem cell-like properties and metabolic phenotype in hepatocellular carcinoma, Int J Cancer. 2019. |
| TAN H.W., LEUNG O.N., Chan K.S., Ho D.W.H., LEUNG M.S., Wong C.M., Ng I.O.L. and Lo C.L.R., Deregulated Gata6 Modulates Stem Cell‐like Properties And Metabolic Phenotype In Hepatocellular Carcinoma, International Journal Of Cancer. 2019, 145: 1860-1873. |
| Wong C.C.L., Ng I.O.L. and Lo C.L.R., Faculty Outstanding Research Output Award, Faculty of Medicine, The University of Hong Kong. 2019. |
| Wong D.K.H., Cheng C.Y.S., Mak L.Y., To W.P., Lo C.L.R., Cheung T.T., Seto W.K.W., Fung J.Y.Y., Man K., Lai C.L. and Yuen R.M.F., Among Patients with Undetectable Hepatitis B Surface Antigen and Hepatocellular Carcinoma, a High Proportion Has Integration of HBV DNA into Hepatocyte DNA and No Cirrhosis, Clinical Gastroenterology and Hepatology. 2019. |
| Researcher : Lo WIA |
| List of Research Outputs |
| LI B., Wong Y.H.I., Lo W.I.A., Chan S.Y. and Law S.Y.K., Impact of extracapsular lymph node involvement in adenocarcinoma of the stomach, Oral Presentation 12: Prognosis, Korea International Gastric Cancer Week 2019 (KINGCA WEEK 2019), Incheon, Korea, 11-13 April 2019. |
| Researcher : Lu L |
| Project Title: | Plasma cell development and its regulation in autoimmunity |
| Investigator(s): | Lu L |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2007 |
| Project Title: | Leptin regulates plasma cell generation and survival in autoimmune arthritis |
| Investigator(s): | Lu L |
| Department: | Pathology |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2014 |
| Project Title: | Outstanding Researcher Award 2012-13 |
| Investigator(s): | Lu L |
| Department: | Pathology |
| Source(s) of Funding: | Outstanding Researcher Award |
| Start Date: | 01/2014 |
| Project Title: | Role of B cells in the pulmonary anti-viral immune response |
| Investigator(s): | Lu L, Ma K |
| Department: | Pathology |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - Major Research Project |
| Start Date: | 01/2015 |
| Project Title: | The Role of B cells in the development of experimental Sjogren's syndrome |
| Investigator(s): | Lu L |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Completion Date: | 12/2019 |
| Project Title: | Studies on the Pathogenesis and Treatment of Sjören’s Syndrome |
| Investigator(s): | Lu L |
| Department: | Pathology |
| Source(s) of Funding: | Croucher Foundation - Research Grants |
| Start Date: | 01/2016 |
| Project Title: | The Role of interleukin-17 in the pathogenesis of experimental Sjögren's syndrome |
| Investigator(s): | Lu L |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2017 |
| Project Title: | The role of B-1 cells in modulating pulmonary T cell response against influenza infection |
| Investigator(s): | Lu L |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2018 |
| Completion Date: | 03/2019 |
| Project Title: | A novel function of Interleukin-17 in inducing salivary gland dysfunction during autoimmune development |
| Investigator(s): | Lu L |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2019 |
| Project Title: | Immunopathogenesis and therapeutic intervention of primary Sjogren's syndrome (CRF) |
| Investigator(s): | Lu L |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding for Strategic Interdisciplinary Research Scheme |
| Start Date: | 06/2019 |
| List of Research Outputs |
| Guggino G., Lin X., Rizzo A., Xiao F., Saieva L., Raimondo S., Di Liberto D., Candore G., Ruscitti P., Cipriani P., Giacomelli R., Dieli F., Alessandro R., Triolo G., Lu L. and Ciccia F., Interleukin-25 Axis Is Involved in the Pathogenesis of Human Primary and Experimental Murine Sjögren's Syndrome, Arthritis & Rheumatology. 2018, 70: 1265-1275. |
| KWOK S.Y.J., Guo M., Yang W., Ip P., LEE C.K., Lu L., Chan G.C.F., Middleton D. and van der Zanden H.G.M., Simulation of non-inherited maternal antigens acceptable HLA mismatches to increase the chance of matched cord blood units: Hong Kong’s experience, Human Immunology. 2018, 79: 539-544. |
| Kwok J.S.Y., Chu P., Ong C.Y.T., Law K., Ip P., Chan G.C.F. and Lu L., Role of Regulatory T Cells in Noninherited Maternal Antigen-Related Tolerance in Cord Blood: An in Vitro Study, Biology of Blood and Marrow Transplantation. 2019, 25: 424-435. |
| Lin X. and Lu L., Best Poster Presentation Award, 2018, Hong Kong Society for Immunology. 2018. |
| Lin X., Wang X., Xiao F., Ma K., Liu L., Wang X., Xu D., Wang F., Shi X., Liu D., Zhao Y. and Lu L., IL-10-producing regulatory B cells restrain the T follicular helper cell response in primary Sjögren’s syndrome, Cellular & Molecular Immunology. 2019. |
| Shi B., Qi J., Yao G., Feng R., Zhang Z., Wang D., Chen C., Tang X., Lu L., Chen W. and Sun L., Mesenchymal stem cell transplantation ameliorates Sjögren’s syndrome via suppressing IL-12 production by dendritic cells, Stem Cell Research & Therapy. 2018, 9. |
| Sun Y., Deng W., Yao G., Chen W., Tang X., Feng X., Lu L. and Sun L., Citrullinated fibrinogen impairs immunomodulatory function of bone marrow mesenchymal stem cells by triggering toll-like receptor, Clinical Immunology. 2018, 193: 38-45. |
| Tian J., Rui K., Hong Y., Wang X., Xiao F., Lin X., Ma J., Guo H., Xu H., Ma K., Xu D., Liu D., Zhao Y., Lu L. and Wang S., Increased GITRL Impairs the Function of Myeloid-Derived Suppressor Cells and Exacerbates Primary Sjögren Syndrome, The Journal of Immunology. 2019, 202: 1693-1703. |
| Wang X., Cong Y., Lin X., Ma K., Xiao F., Dong L. and Lu L., New insights into the significance of the BCR repertoire in B-1 cell development and function, Cellular & Molecular Immunology. 2019. |
| Wu H., Deng Y., Feng Y., Long D., Ma K., Wang X., Zhao M., Lu L. and Lu Q., Epigenetic regulation in B-cell maturation and its dysregulation in autoimmunity, Cellular & Molecular Immunology. 2018, 15: 676-684. |
| Researcher : MA PY |
| List of Research Outputs |
| MA P.Y. and Yam J.W.P., Suppression of fatty acid oxidation by caveolin-1 contributes to hepatocellular carcinoma progression, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019. |
| Researcher : MOK KC |
| List of Research Outputs |
| Khoo U.S., MOK K.C., Man P.S., Chau K.M., Lee T.K. and Gong C., Hyperpolarization-activated cyclic nucleotide-gated channel (HCN) blocker, Ivabradine, a novel potential targeted treatment for triple-negative breast cancer., 30th EORTC-NCI-AACR Symposium, Dublin, Ireland. 13-16 November 2018.. 2018. |
| Researcher : Ma K |
| List of Research Outputs |
| Lin X., Wang X., Xiao F., Ma K., Liu L., Wang X., Xu D., Wang F., Shi X., Liu D., Zhao Y. and Lu L., IL-10-producing regulatory B cells restrain the T follicular helper cell response in primary Sjögren’s syndrome, Cellular & Molecular Immunology. 2019. |
| Tian J., Rui K., Hong Y., Wang X., Xiao F., Lin X., Ma J., Guo H., Xu H., Ma K., Xu D., Liu D., Zhao Y., Lu L. and Wang S., Increased GITRL Impairs the Function of Myeloid-Derived Suppressor Cells and Exacerbates Primary Sjögren Syndrome, The Journal of Immunology. 2019, 202: 1693-1703. |
| Wang X., Cong Y., Lin X., Ma K., Xiao F., Dong L. and Lu L., New insights into the significance of the BCR repertoire in B-1 cell development and function, Cellular & Molecular Immunology. 2019. |
| Wu H., Deng Y., Feng Y., Long D., Ma K., Wang X., Zhao M., Lu L. and Lu Q., Epigenetic regulation in B-cell maturation and its dysregulation in autoimmunity, Cellular & Molecular Immunology. 2018, 15: 676-684. |
| Researcher : Ma W |
| List of Research Outputs |
| Ma W., Ho D.W.H., Sze M.F., Tsui Y.M., Chan L.K., Lee E. and Ng I.O.L., APOBEC3B promotes hepatocarcinogenesis and metastasis through novel deaminase‐independent activity, Molecular Carcinogenesis. 2019, 58: 643-653. |
| Researcher : Man HY |
| List of Research Outputs |
| Yan H.H.N., Siu H.C., Law S.Y.K., Ho R.S.L., Yue S.K.S., Tsui W.Y., Chan D., Chan A.S., Ma S.K.Y., Lam K.O., Bartfeld S., Man H.Y., Lee C.H., Chan A.S.Y., Wong W.H.J., Cheng S.W.P., Chan K.W., Zhang J., Shi J., Fan X., Kwong D.L.W., Mak T.W., Yuen S.T., Clevers H. and Leung S.Y., A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening, Cell Stem Cell. 2018. |
| Researcher : Man PS |
| List of Research Outputs |
| Khoo U.S., MOK K.C., Man P.S., Chau K.M., Lee T.K. and Gong C., Hyperpolarization-activated cyclic nucleotide-gated channel (HCN) blocker, Ivabradine, a novel potential targeted treatment for triple-negative breast cancer., 30th EORTC-NCI-AACR Symposium, Dublin, Ireland. 13-16 November 2018.. 2018. |
| SHI L., Tsoi H., Dong M., Man P.S. and Khoo U.S., Overexpression of BQ323636.1 modulated modulates tamoxifen resistance in ER positive breast cancer via IL-8-mediated signaling pathway., AACR Annual Meeting, Atlanta, March 29- April 3, 2019.. 2019. |
| Researcher : Mao X |
| Project Title: | Inhibition of reactive oxygen species upregulation of caveolin-1 by propofol contributes to the suppression of hepatocellular growth and aggressiveness |
| Investigator(s): | Mao X, Yam JWP |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2018 |
| List of Research Outputs |
| Mao X., Tey S.K., Ko F.C.F., Kwong M.L., Goa Y., Ng I.O.L., Cheung S.T., Guan X. and Yam J.W.P., C-terminal truncated HBx protein activates caveolin-1/LRP6/β-catenin/FRMD5 axis in promoting hepatocarcinogenesis, Cancer Letters. 2019, 444: 60-69. |
| Mao X., Tey S.K. and Yam J.W.P., Exosomal nidogen 1 drives liver cancer metastasis by inducing secretion of tumor necrosis factor receptor 1 from activated lung fibroblasts, ISEV (The International Society for Extracellular Vesicles) 2019 Annual meeting. 2019. |
| Mao X., Ko F.C.F., Tey S.K., Man K., Lo C.L.R., Ng I.O.L. and Yam J.W.P., Hypoxia-induced caveolin-1 drives tumorigenesis and metastasis by activation of NF-κB/S100P pathway in hepatocellular carcinoma, Health Research Symposium 2019. |
| Researcher : Nanji AA |
| Project Title: | 10th Congress of the International Society for Biomedical Research on Alcoholism Mechanisms of Apoptosis in Alcoholic Liver Disease |
| Investigator(s): | Nanji AA |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2000 |
| Researcher : Ng IOL |
| Project Title: | Characterization of the roles of hepatitis B virus X protein in liver cancer |
| Investigator(s): | Ng IOL, Chan DW |
| Department: | Pathology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 09/2006 |
| Project Title: | Outstanding Research Student Supervisor Award 2007-2008 |
| Investigator(s): | Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Outstanding Research Student Supervisor Award |
| Start Date: | 10/2008 |
| Project Title: | The Use of Anti-DKK1 (anti-Dickkopf-1) Monoclonal Antibody for Treatment of Liver Cancer |
| Investigator(s): | Ng IOL, Tung KK |
| Department: | Pathology |
| Source(s) of Funding: | Innovation and Technology Support Programme (Tier 3) |
| Start Date: | 09/2011 |
| Project Title: | Cancer Biology |
| Investigator(s): | Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Croucher Summer Courses |
| Start Date: | 08/2013 |
| Project Title: | The role of SUMO-specific protease SENP1 in liver cancer |
| Investigator(s): | Ng IOL, Wong CCL, Cui C |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2015 |
| Project Title: | Characterization of anti-CCL28 as a novel therapy to overcome sorafenib resistance in HCC |
| Investigator(s): | Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2016 |
| Completion Date: | 03/2019 |
| Project Title: | Role of RalA and RalGAP in liver cancer |
| Investigator(s): | Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| Completion Date: | 11/2018 |
| Project Title: | The role of RalA GTPase and its regulator RalGAP in liver cancer |
| Investigator(s): | Ng IOL, Chan LK, Ho DWH |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2017 |
| Project Title: | Understanding Cancer Stemness in Liver Cancer – From Regulation to Translational Applications |
| Investigator(s): | Ng IOL, Guan X, Sham PC, Wong CCL, Ching YP, Jin D, Ma SKY, Mak TW, Wong CM, Poon RTP, Yau TCC, Cheung TT |
| Department: | Pathology |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 01/2017 |
| Project Title: | A comprehensive study on the effects of antioxidant supplements in liver cancer development and treatment |
| Investigator(s): | Ng IOL, Wong CCL |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2017 |
| Project Title: | The role of hypoxia-induced ephrinA3-ephrin receptor signaling in liver cancer |
| Investigator(s): | Ng IOL, Chiu YT |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| Completion Date: | 06/2019 |
| Project Title: | Innovative Study of Hepatocarcinogenesis |
| Investigator(s): | Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Ministry of Science and Technology of The People's Republic of China (MOST) |
| Start Date: | 01/2018 |
| Project Title: | Genetic changes, expression and molecular mechanisms of TSC complex in liver cancer |
| Investigator(s): | Ng IOL, Chan LK |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2018 |
| Project Title: | American Association for the Study of Liver Annual Meeting; ELF4 Co-Operates with HBV DNA Integration at the TERT Promoter to Enhance Hepatocarcinogenesis |
| Investigator(s): | Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2018 |
| Completion Date: | 11/2018 |
| Project Title: | High-throughput dispensing system for multi-purpose library screening and full-length single-cell transcriptomics sequencing under hypoxia |
| Investigator(s): | Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Small Equipment Grant |
| Start Date: | 04/2019 |
| Project Title: | Nanoparticle Tracking Analyzer for the measurement of biological nanoparticles |
| Investigator(s): | Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Small Equipment Grant |
| Start Date: | 04/2019 |
| List of Research Outputs |
| Chan L.K. and Ng I.O.L., Proteomic profiling in liver cancer: another new page, Translational Gastroenterology and Hepatology. AME Publishing Company, 2019, 4: 47. |
| Fung J.Y.Y., Wong D.K.H., Tanaka Y., Lo C.L.R., Wong C.L.T., Chok K.S.H., Chan A.C.Y., Cheung T.T., Dai W.C., Ng K.C.K., Ng K.T.P., Man K., Ng I.O.L., Seto W.K.W., Lai C.L., Yuen R.M.F. and Lo C.M., Quantitative hepatitis B surface antigen in predicting recurrence of hepatitis B-related hepatocellular carcinoma after liver transplantation, Hepatoma Research. 2018, 4: 62. |
| Ho D.W.H., Tsui Y.M., Sze M.F., Chan L.K., Cheung T.T., Cheng L., Lee E., Wu A.R., Sham P.C., Tsui S.K.W., Lee T.K.W. and Ng I.O.L., Single-Cell Transcriptome Sequencing Reveals Intra-Tumor Heterogeneity and Rare Stemness-Related Cell Subpopulation in Hepatocellular Carcinoma, 12th Annual Conference of the International Liver Cancer Association. 2018. |
| Ho D.W.H., Tsui Y.M., Sze M.F., Chan L.K., Cheung T.T., Cheng L., Lee E., Wu A.R., Sham P.C., Tsui S.K., Lee T.K. and Ng I.O.L., Single-Cell Transcriptome Sequencing Reveals Intra-Tumor Heterogeneity and Rare Stemness-Related Cell Subpopulation in Hepatocellular Carcinoma, 9th Asia-Pacific Primary Liver Cancer Expert Meeting. 2018. |
| Law C.T., Tsang F.H., Chan C.Y., XU M., Lai R.K., Ho D.W.H., Lee J.K.M., Wong C.C.L., Ng I.O.L. and Wong C.M., Chromatin remodeler HELLS is an epigenetic driver for hepatocellular carcinoma progression. , Hepatology . 2019. |
| Lee D., XU M., CHIU K.C., Leibold J., Tse P.W., Bao H.R., Yuen W.H., Chan Y.K., LAI K.H., Chin W.C., Chan F.F., Cheung T.T., Chok K.S.H., Wong C.M., Lowe S.W., Ng I.O.L. and Wong C.C.L., Induction of oxidative stress through inhibition of thioredoxin reductase 1 is an effective therapeutic approach for hepatocellular carcinoma, Hepatology. 2019, 69: 1768-1786. |
| Lim C.J., Lee Y.H., Pan L., Lai L., Chua C., Wasser M., Lim T.K.H., Yeong J., Toh H.C., Lee S.Y., Chan C.Y., Goh B.K., Chung A., Heikenwalder M., Ng I.O.L., Chow P., Albani S. and Chew V., Multidimensional analyses reveal distinct immune microenvironment in hepatitis B virus-related hepatocellular carcinoma., Gut. 2019. |
| Ma W., Ho D.W.H., Sze M.F., Tsui Y.M., Chan L.K., Lee E. and Ng I.O.L., APOBEC3B promotes hepatocarcinogenesis and metastasis through novel deaminase‐independent activity, Molecular Carcinogenesis. 2019, 58: 643-653. |
| Mao X., Tey S.K., Ko F.C.F., Kwong M.L., Goa Y., Ng I.O.L., Cheung S.T., Guan X. and Yam J.W.P., C-terminal truncated HBx protein activates caveolin-1/LRP6/β-catenin/FRMD5 axis in promoting hepatocarcinogenesis, Cancer Letters. 2019, 444: 60-69. |
| Mao X., Ko F.C.F., Tey S.K., Man K., Lo C.L.R., Ng I.O.L. and Yam J.W.P., Hypoxia-induced caveolin-1 drives tumorigenesis and metastasis by activation of NF-κB/S100P pathway in hepatocellular carcinoma, Health Research Symposium 2019. |
| Ng I.O.L., Clinical implication of molecular classifications in HCC, 9th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2018), Seoul, Korea. 2018. |
| Ng I.O.L. and Lo C.L.R., Faculty Outstanding Research Output Award, LKS Faculty of Medicine, HKU. 2018. |
| Ng I.O.L., Hepatology. 2019. |
| Ng I.O.L., Hepatology (Associate Editor), 2019. |
| Ng I.O.L., Hepatology (Associate Editor), 2018. |
| Ng I.O.L., Liver cancer: Updates in cell signaling and applications in personalized medicine, Gordon Research Conference (Personalized Medicine) 2018, Hong Kong. 2018. |
| Ng I.O.L., Mechanisms, Cell signaling, and Translational Applications in Liver Cancer, Frontiers in Stem Cell and Cancer Research, Shanghai. 2019. |
| Ng I.O.L., Molecular Diversity in HCC - Liquid Biopsy in HCC: Strengths and Limitations, Single Topic Workshops, International Liver Cancer Association, London. 2018. |
| Ng I.O.L., Molecular pathogenesis of hepatocellular carcinoma, 9th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2018), Seoul, Korea. 2018. |
| Ng I.O.L., Molecular pathogenesis of hepatocellular carcinoma’, Dr V. Ramalingaswami Oration and Hepatopathology Meeting 2018, New Delhi, India. 2018. |
| Ng I.O.L., Targeting cancer stem cells in HCC, 9th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2018), Seoul, Korea. 2018. |
| TAN H.W., Leung C.O., Chan K.K., Ho D.W.H., Leung M.S., Wong C.M., Ng I.O.L. and Lo C.L.R., Deregulated GATA6 modulates stem cell-like properties and metabolic phenotype in hepatocellular carcinoma, Int J Cancer. 2019. |
| TAN H.W., LEUNG O.N., Chan K.S., Ho D.W.H., LEUNG M.S., Wong C.M., Ng I.O.L. and Lo C.L.R., Deregulated Gata6 Modulates Stem Cell‐like Properties And Metabolic Phenotype In Hepatocellular Carcinoma, International Journal Of Cancer. 2019, 145: 1860-1873. |
| Tsang F.H., LAW C.T., Tang T.C.C., Cheng C.L., Chin D.W., Tam W.S.V., Wei L., Wong C.C.L., Ng I.O.L. and Wong C.M., Aberrant super-enhancer landscape in human hepatocellular carcinoma, Hepatology. 2019. |
| Wong C.C.L., Ng I.O.L. and Lo C.L.R., Faculty Outstanding Research Output Award, Faculty of Medicine, The University of Hong Kong. 2019. |
| Zhao L., Chan L.K., Ho D.W.H., Tsui Y.M., Sze M.F., Zhang X., Lee M.F. and Ng I.O.L., RalA is frequently up-regulated in human hepatocellular carcinoma and promotes metastasis and cancer stemness, AACR (American Association for Cancer Research) Annual Meeting 2018. |
| Researcher : Ngan HYS |
| Project Title: | High dose cis-platinum and cyclophosphamide vs taxol in ovarian cancer |
| Investigator(s): | Ngan HYS, Wong LCR |
| Department: | Obstetrics & Gynaecology |
| Source(s) of Funding: | Other Funding Scheme |
| Start Date: | 07/1994 |
| Project Title: | Functional characterization of the roles of NR4A2 in cervical cancer cells |
| Investigator(s): | Ngan HYS, Leung THY, Siu KY, Chan KKL |
| Department: | Obstetrics & Gynaecology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2017 |
| Completion Date: | 03/2019 |
| Project Title: | Investigation on the association of CD109 and STAT3 activity in regulating cervical cancer cell metastasis |
| Investigator(s): | Ngan HYS, Leung THY, Siu KY, Chan KKL |
| Department: | Obstetrics & Gynaecology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2018 |
| Project Title: | Characterization of the molecular mechanisms associated with ovarian cancer cells chemoresistance through a three-dimensional cell culture system |
| Investigator(s): | Ngan HYS, Chan DW, Yung MH |
| Department: | Obstetrics & Gynaecology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2019 |
| List of Research Outputs |
| Wong G.W., Cheung L.Y., Ip P.C.P., Ngan H.Y.S. and Cheung A.N.Y., Amyloid Precursor Protein Overexpression in Down Syndrome Trophoblast Reduces Cell Invasiveness and Interferes with Syncytialization., American Journal of Pathology. 2018, 188: 2307-2317. |
| Researcher : Nicholls JM |
| Project Title: | Susceptibility of the upper respiratory tract to influenza virus infection following desialyation |
| Investigator(s): | Nicholls JM, Chan MCW, Kwong DLW |
| Department: | Pathology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2009 |
| Project Title: | Sialoglyco 2014; Glycomic Characterization of Respiratory Tract Tissues of Ferrets Shows Expression of Different Sialylatyed Glycans to Humans: Implications for the Use of Ferrets in Influenza Virus Infection Studies. |
| Investigator(s): | Nicholls JM |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2014 |
| Project Title: | Modulation of MERS-CoV infection of the human ex vivo respiratory tract by the use of interferon, cyclophilin inhibitors and blocking antibody therapy |
| Investigator(s): | Nicholls JM, Chan WY |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2015 |
| Project Title: | The viral genetic determinants of influenza H5N1 virus in causing acute lung injury - an in vitro study |
| Investigator(s): | Nicholls JM, Chan MCW |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 09/2015 |
| Completion Date: | 08/2019 |
| Project Title: | ESWI 2017 Influenza Conference; The Influence On Influenza Replication by the Sda Epitope |
| Investigator(s): | Nicholls JM |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2017 |
| List of Research Outputs |
| Bui H.T., Ng M.M.T., Cheung M.C., Fong H.M., Nicholls J.M., Peiris J.S.M., Chan W.Y. and Chan M.C.W., Use of ex vivo and in vitro model of human respiratory tract to study the tropism, replication competence and pathogenesis of influenza B virus., Keystone Symposium. 2018. |
| Chan L.Y., Hui P.Y., Kuok I.T., Bui H.T., Ng K.C., Mok K.P., Yang Z., Guan W., Poon L.M.L., Zhong N., Peiris J.S.M., Nicholls J.M. and Chan M.C.W., Risk assessment of the tropism & pathogenesis of the highly pathogenic avian influenza A/H7N9 virus using ex vivo & in vitro cultures of human respiratory tract., The Journal of Infectious Diseases. 2019, 220(4): 578-88. |
| Chan S., Wang R., Man K., Nicholls J.M., Li H., Sun H. and Chan G.C.F., A novel synthetic compound, bismuth zinc citrate, could potentially reduce cisplatin-induced toxicity without compromising the anticancer effect through enhanced expression of antioxidant protein, Translational Oncology. Elsevier Inc, 2019, 12: 788-799. |
| Cheung M.C., Kuok I.T., Chin W.H., Hui P.Y., Poon L.M.L., Nicholls J.M., Peiris J.S.M. and Chan M.C.W., Alveolar Regeneration Upon Highly Pathogenic Influenza A/ H5N1 virus Induced Acute Lung Injury. , Keystone Symposium Molecular & Cellular Biology. . 2018. |
| Hui P.Y., Kuok I.T., Bui H.T., Ng K.C., Mok K.P., Yang Z., Guan W., Poon L.M.L., Zhong N., Guan Y., Hans C.L.E.V.E.R.S., Peiris J.S.M., Nicholls J.M. and Chan M.C.W., Tropism and pathogenesis of the avian influenza A/H7N9 virus in ex vivo and in vitro cultures of the human respiratory tract and human airway organoids., Framing the Response to Emerging Virus Infections. 2018. |
| Hui P.Y., Chan W.Y., Chu K.W., Poon L.M.L., Guan Y., Nicholls J.M., Peiris J.S.M. and Chan M.C.W., Tropism of the novel human betacoronavirus lineage C virus in human ex vivo and in vitro cultures, as an assessment of its potential transmissibility and pathogenesis in humans, Health Research Symposium 2019. |
| Hui P.Y., Ching H.H., Chan K.H., Nicholls J.M., Sachs N., Clevers H., Peiris J.S.M. and Chan M.C.W., Tropism, replication competence, and innate immune responses of influenza virus: an analysis of human airway organoids and ex-vivo bronchus cultures., The Lancet Respiratory Medicine. 2018, 6(11): 846-854. |
| Kuok I.T., Ng M.M.T., Nicholls J.M., Peiris J.S.M. and Chan M.C.W., Risk assessment on potential disease severity and tissue tropism of influenza virus using in vitro and ex vivo models of human respiratory tract, Framing the Response to Emerging Virus Infections. 2018. |
| LI H.S., Kuok I.T., Cheung M.C., NG M.T., Ng K.C., Hui P.Y., Peiris J.S.M., Chan M.C.W. and Nicholls J.M., Effect of interferon alpha and cyclosporine treatment separately and in combination on Middle East Respiratory Syndrome Coronavirus (MERS-CoV) replication in a human in-vitro and ex-vivo culture model, Antiviral Research. 2018, 155: 89-96. |
| LOY H., KUOK I.T., Hui P.Y., Choi H.L., Yuen W., Nicholls J.M., Peiris J.S.M. and Chan M.C.W., Therapeutic implications of human umbilical cord mesenchymal stromal cells in attenuating influenza A(H5N1) virus–associated acute lung injury, The Journal of Infectious Diseases. 2018, 219(2): 186–96. |
| LOY H., Kuok I.T., Hui P.Y., Choi M., Yuen W., Nicholls J.M., Peiris J.S.M. and Chan M.C.W., Therapeutic implications of human umbilical cord mesenchymal stromal cells in attenuating influenza A/H5N1-associated acute lung injury. , Journal of Infectious Diseases. 2019, 219: 186-196. |
| Lai J.C.C., HERATH MUDIYANSELAGE T.K.K..., Wong H.H., Peiris J.S.M. and Nicholls J.M., Neuraminidase activity and specificity of influenza A virus are influenced by haemagglutinin-receptor binding, Emerging Microbes & Infections. 2019, 8(1): 327-338. |
| Lin W., Yip Y.L., Jia L.J., Deng W., Zheng H., Dai W., Ko J.M.Y., Lo K.W., Chung G.T.Y., Yip K.Y., Lee S.D., Kwan J.S.H., Zhang J., Liu T.F., Chan Y.W., Kwong D.L.W., Lee V.H.F., Nicholls J.M., Busson P., Liu X.F., Chiang A.K.S., Hui K.F., Kwok H., Cheung S.T., Cheung Y.C., Chan C.K., Li B., Cheung A., Hau P.M., Zhou Y., Tsang C.M., Middeldorp J., Chen H., Lung M.L. and Tsao G.S.W., Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma, Nature Communications. 2018, 7; 9(1): 4663. |
| Researcher : SHI L |
| List of Research Outputs |
| SHI L., Tsoi H., Dong M., Man P.S. and Khoo U.S., Overexpression of BQ323636.1 modulated modulates tamoxifen resistance in ER positive breast cancer via IL-8-mediated signaling pathway., AACR Annual Meeting, Atlanta, March 29- April 3, 2019.. 2019. |
| Researcher : Shek TWH |
| List of Research Outputs |
| Co T.H.M., Cheng C.C.V., Wei J., Wong C.Y.S., Chan S.M.S., Shek T.W.H. and Kwong A., Idiopathic granulomatous mastitis: a 10-year study from a multicentre clinical database, Pathology. 2018, 50: 742-747. |
| Wong K.P., Lang H.H.B., Lam K.O., Shek T.W.H. and Yau T.C.C., Poster presentation: PD-L1 expression in patients with anaplastic thyroid carcinoma: prevalence and outcome, The 88th Annual Meeting of the American Thyroid Association (ATA), Washington, U.S.A., 3-7 October 2018. 2018. |
| Researcher : Sin CF |
| Researcher : Siu HC |
| List of Research Outputs |
| Yan H.H.N., Siu H.C., Law S.Y.K., Ho R.S.L., Yue S.K.S., Tsui W.Y., Chan D., Chan A.S., Ma S.K.Y., Lam K.O., Bartfeld S., Man H.Y., Lee C.H., Chan A.S.Y., Wong W.H.J., Cheng S.W.P., Chan K.W., Zhang J., Shi J., Fan X., Kwong D.L.W., Mak T.W., Yuen S.T., Clevers H. and Leung S.Y., A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening, Cell Stem Cell. 2018. |
| Yan H.H.N., Chan D., Siu H.C., Law S.Y.K., Ho R.S.L., Tsui W.Y., Yue S.K.S., Chan A.S., Lee C.H., Chan A.S.Y., Chan K.W., Leung H.C., Hui H.S., Lam K.O., Kwong D.L.W., Mak T.W., Clevers H. and Leung S.Y., Establishment of a large-scale drug sensitivity screening platform on gastric cancer organoid cultures with potential to guide treatment. , American Association for Cancer Research (AACR) and Korean Cancer Association (KCA) Joint Conference on Precision Medicine in Solid Tumors. 2018. |
| Researcher : Siu KY |
| Project Title: | Effects of folate and folate receptor on ovarian and endometrial cancer: an in vitro study |
| Investigator(s): | Siu KY, Cheung ANY |
| Department: | Pathology |
| Source(s) of Funding: | American Institute for Cancer Research (AICR) - General Award |
| Start Date: | 07/2006 |
| Project Title: | p21-activated kinase 4: a prognostic and therapeutic target for ovarian carcinoma? |
| Investigator(s): | Siu KY, Cheung ANY, Ngan HYS |
| Department: | Pathology |
| Source(s) of Funding: | The Hong Kong Anti-Cancer Society (HKACS) - General Award |
| Start Date: | 10/2007 |
| Researcher : So JCC |
| List of Research Outputs |
| Singh G.H.H., Ip H.W., Yim R.L.H., Tang W.F., Pang H.M.H., Lee P., Leung G.M.K., Li J.W.Y., Tang K., So J.C.C., Leung R.Y.Y., Li J., Panagiotou I., Lam C.C.K. and Kwong Y.L., Next-generation sequencing with a 54-gene panel identified unique mutational profile and prognostic markers in Chinese patients with myelofibrosis, Annals of Hematology. 2018. |
| Researcher : Srivastava G |
| Project Title: | Effect of t(11;14)(p13;q32) translocation on the expression of PDHX, the telomeric gene on chromosome 11p13, in GCB-derived lymphomas |
| Investigator(s): | Srivastava G |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2012 |
| Researcher : Sze MF |
| List of Research Outputs |
| Ho D.W.H., Tsui Y.M., Sze M.F., Chan L.K., Cheung T.T., Cheng L., Lee E., Wu A.R., Sham P.C., Tsui S.K.W., Lee T.K.W. and Ng I.O.L., Single-Cell Transcriptome Sequencing Reveals Intra-Tumor Heterogeneity and Rare Stemness-Related Cell Subpopulation in Hepatocellular Carcinoma, 12th Annual Conference of the International Liver Cancer Association. 2018. |
| Ho D.W.H., Tsui Y.M., Sze M.F., Chan L.K., Cheung T.T., Cheng L., Lee E., Wu A.R., Sham P.C., Tsui S.K., Lee T.K. and Ng I.O.L., Single-Cell Transcriptome Sequencing Reveals Intra-Tumor Heterogeneity and Rare Stemness-Related Cell Subpopulation in Hepatocellular Carcinoma, 9th Asia-Pacific Primary Liver Cancer Expert Meeting. 2018. |
| Ma W., Ho D.W.H., Sze M.F., Tsui Y.M., Chan L.K., Lee E. and Ng I.O.L., APOBEC3B promotes hepatocarcinogenesis and metastasis through novel deaminase‐independent activity, Molecular Carcinogenesis. 2019, 58: 643-653. |
| Zhao L., Chan L.K., Ho D.W.H., Tsui Y.M., Sze M.F., Zhang X., Lee M.F. and Ng I.O.L., RalA is frequently up-regulated in human hepatocellular carcinoma and promotes metastasis and cancer stemness, AACR (American Association for Cancer Research) Annual Meeting 2018. |
| Researcher : TAN HW |
| List of Research Outputs |
| TAN H.W., Leung C.O., Chan K.K., Ho D.W.H., Leung M.S., Wong C.M., Ng I.O.L. and Lo C.L.R., Deregulated GATA6 modulates stem cell-like properties and metabolic phenotype in hepatocellular carcinoma, Int J Cancer. 2019. |
| TAN H.W., LEUNG O.N., Chan K.S., Ho D.W.H., LEUNG M.S., Wong C.M., Ng I.O.L. and Lo C.L.R., Deregulated Gata6 Modulates Stem Cell‐like Properties And Metabolic Phenotype In Hepatocellular Carcinoma, International Journal Of Cancer. 2019, 145: 1860-1873. |
| Researcher : Tam S |
| List of Research Outputs |
| Wong H.Y.Q., Li R.H.W., Lam K.S.L., Tam S., Shek C.C., Lee V.C.Y., Yeung W.S.B., Ho P.C. and Ng E.H.Y., Independent association of serum vitamin D with anti-Mullerian hormone levels in women with polycystic ovary syndrome, Clinical Endocrinology. 2018. |
| Zhu H., Lee C.Y., Li C., Mak W.N., Chen Y., Chan K.H., Zhang J., Fung W.F., Zhang R.Q., Fung Y.F., Poon W.S.R., Lam J.Y., Tam S., Hung F.N.I., Chen H., Yuen K.Y. and To K.K.W., Low population serum microneutralization antibody titer against the predominating influenza A(H3N2) N121K virus during the severe influenza summer peak of Hong Kong in 2017, Emerging Microbes & Infections. New York, NPG, 2018, 7: 23. |
| Researcher : Tam WSV |
| List of Research Outputs |
| Tsang F.H., LAW C.T., Tang T.C.C., Cheng C.L., Chin D.W., Tam W.S.V., Wei L., Wong C.C.L., Ng I.O.L. and Wong C.M., Aberrant super-enhancer landscape in human hepatocellular carcinoma, Hepatology. 2019. |
| Researcher : Tang HW |
| List of Research Outputs |
| CHENG Y.H., TAM S.C.T., Chau S.L., LAI K.M., Tang H.W., Lok C.N., Lam C.W. and Ng K.M., Plasmonic gold nanoparticles as multifaceted probe for tissue imaging, In: Cheng YH, Tam TS , Chau SL , Lai SK , Tang HW , Lok CN , Lam CW , Ng KM , Chemical Communications. 2019, 55: 2761-2764. |
| Researcher : Tang TCC |
| List of Research Outputs |
| Tsang F.H., LAW C.T., Tang T.C.C., Cheng C.L., Chin D.W., Tam W.S.V., Wei L., Wong C.C.L., Ng I.O.L. and Wong C.M., Aberrant super-enhancer landscape in human hepatocellular carcinoma, Hepatology. 2019. |
| Researcher : Tey SK |
| Project Title: | Annual Meeting ISEV 2019; Patient-derived circulating exosomes enhance cancer and stemness properties through polymeric immunoglobulin receptor in liver cancer |
| Investigator(s): | Tey SK |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2019 |
| Completion Date: | 04/2019 |
| List of Research Outputs |
| Mao X., Tey S.K., Ko F.C.F., Kwong M.L., Goa Y., Ng I.O.L., Cheung S.T., Guan X. and Yam J.W.P., C-terminal truncated HBx protein activates caveolin-1/LRP6/β-catenin/FRMD5 axis in promoting hepatocarcinogenesis, Cancer Letters. 2019, 444: 60-69. |
| Mao X., Tey S.K. and Yam J.W.P., Exosomal nidogen 1 drives liver cancer metastasis by inducing secretion of tumor necrosis factor receptor 1 from activated lung fibroblasts, ISEV (The International Society for Extracellular Vesicles) 2019 Annual meeting. 2019. |
| Mao X., Ko F.C.F., Tey S.K., Man K., Lo C.L.R., Ng I.O.L. and Yam J.W.P., Hypoxia-induced caveolin-1 drives tumorigenesis and metastasis by activation of NF-κB/S100P pathway in hepatocellular carcinoma, Health Research Symposium 2019. |
| Tey S.K. and Yam J.W.P., Patient-derived circulating exosomes enhance cancer and stemness properties through polymeric immunoglobulin receptor in liver cancer, ISEV (The International Society for Extracellular Vesicles) 2019 Annual meeting. 2019. |
| Tey S.K., Role of Exosomes in Liver Cancer Metastasis, ISEV 2018 Guangzhou Workshop: EV-based Clinical Theranostics. 2018. |
| Researcher : Tin PC |
| List of Research Outputs |
| Wong M.P., Xiao Z., Tin P.C. and Ho J.C.M., Uncovering Tyrosine Kinase Inhibitor Resistance Mutations In EGFR Mutant Lung Adenocarcinoma Using Whole Exome Sequencing, Cancer Genomics Conference. 2019. |
| Researcher : Tsang FH |
| List of Research Outputs |
| Law C.T., Tsang F.H., Chan C.Y., XU M., Lai R.K., Ho D.W.H., Lee J.K.M., Wong C.C.L., Ng I.O.L. and Wong C.M., Chromatin remodeler HELLS is an epigenetic driver for hepatocellular carcinoma progression. , Hepatology . 2019. |
| Tsang F.H., LAW C.T., Tang T.C.C., Cheng C.L., Chin D.W., Tam W.S.V., Wei L., Wong C.C.L., Ng I.O.L. and Wong C.M., Aberrant super-enhancer landscape in human hepatocellular carcinoma, Hepatology. 2019. |
| Researcher : Tse PW |
| List of Research Outputs |
| Lee D., XU M., CHIU K.C., Leibold J., Tse P.W., Bao H.R., Yuen W.H., Chan Y.K., LAI K.H., Chin W.C., Chan F.F., Cheung T.T., Chok K.S.H., Wong C.M., Lowe S.W., Ng I.O.L. and Wong C.C.L., Induction of oxidative stress through inhibition of thioredoxin reductase 1 is an effective therapeutic approach for hepatocellular carcinoma, Hepatology. 2019, 69: 1768-1786. |
| Researcher : Tsoi H |
| Project Title: | Targeting interleukin-6 receptor in BQ323636.1 overexpressing ER+ breast cancer to reverse tamoxifen resistance |
| Investigator(s): | Tsoi H, Khoo US |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2019 |
| List of Research Outputs |
| SHI L., Tsoi H., Dong M., Man P.S. and Khoo U.S., Overexpression of BQ323636.1 modulated modulates tamoxifen resistance in ER positive breast cancer via IL-8-mediated signaling pathway., AACR Annual Meeting, Atlanta, March 29- April 3, 2019.. 2019. |
| Researcher : Tsui EY |
| List of Research Outputs |
| Wong G.W., Tsun O.K.L., Tsui E.Y., Chow N.K., Ip P.C.P. and Cheung A.N.Y., HPV genotyping and E6/E7 transcript assays for cervical lesion detection in an Asian screening population—Cobas and Aptima HPV tests, Journal of Clinical Virology. 2018, 109: 13-18. |
| Researcher : Tsui WY |
| List of Research Outputs |
| Yan H.H.N., Siu H.C., Law S.Y.K., Ho R.S.L., Yue S.K.S., Tsui W.Y., Chan D., Chan A.S., Ma S.K.Y., Lam K.O., Bartfeld S., Man H.Y., Lee C.H., Chan A.S.Y., Wong W.H.J., Cheng S.W.P., Chan K.W., Zhang J., Shi J., Fan X., Kwong D.L.W., Mak T.W., Yuen S.T., Clevers H. and Leung S.Y., A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening, Cell Stem Cell. 2018. |
| Yan H.H.N., Chan D., Siu H.C., Law S.Y.K., Ho R.S.L., Tsui W.Y., Yue S.K.S., Chan A.S., Lee C.H., Chan A.S.Y., Chan K.W., Leung H.C., Hui H.S., Lam K.O., Kwong D.L.W., Mak T.W., Clevers H. and Leung S.Y., Establishment of a large-scale drug sensitivity screening platform on gastric cancer organoid cultures with potential to guide treatment. , American Association for Cancer Research (AACR) and Korean Cancer Association (KCA) Joint Conference on Precision Medicine in Solid Tumors. 2018. |
| Researcher : Tsui YM |
| List of Research Outputs |
| Ho D.W.H., Tsui Y.M., Sze M.F., Chan L.K., Cheung T.T., Cheng L., Lee E., Wu A.R., Sham P.C., Tsui S.K.W., Lee T.K.W. and Ng I.O.L., Single-Cell Transcriptome Sequencing Reveals Intra-Tumor Heterogeneity and Rare Stemness-Related Cell Subpopulation in Hepatocellular Carcinoma, 12th Annual Conference of the International Liver Cancer Association. 2018. |
| Ho D.W.H., Tsui Y.M., Sze M.F., Chan L.K., Cheung T.T., Cheng L., Lee E., Wu A.R., Sham P.C., Tsui S.K., Lee T.K. and Ng I.O.L., Single-Cell Transcriptome Sequencing Reveals Intra-Tumor Heterogeneity and Rare Stemness-Related Cell Subpopulation in Hepatocellular Carcinoma, 9th Asia-Pacific Primary Liver Cancer Expert Meeting. 2018. |
| Ma W., Ho D.W.H., Sze M.F., Tsui Y.M., Chan L.K., Lee E. and Ng I.O.L., APOBEC3B promotes hepatocarcinogenesis and metastasis through novel deaminase‐independent activity, Molecular Carcinogenesis. 2019, 58: 643-653. |
| Zhao L., Chan L.K., Ho D.W.H., Tsui Y.M., Sze M.F., Zhang X., Lee M.F. and Ng I.O.L., RalA is frequently up-regulated in human hepatocellular carcinoma and promotes metastasis and cancer stemness, AACR (American Association for Cancer Research) Annual Meeting 2018. |
| Researcher : Tsun OKL |
| List of Research Outputs |
| Wong G.W., Tsun O.K.L., Tsui E.Y., Chow N.K., Ip P.C.P. and Cheung A.N.Y., HPV genotyping and E6/E7 transcript assays for cervical lesion detection in an Asian screening population—Cobas and Aptima HPV tests, Journal of Clinical Virology. 2018, 109: 13-18. |
| Researcher : Wang X |
| Project Title: | IL-17-producing γδ T cell response and its regulation during influenza virus infection |
| Investigator(s): | Wang X, Lu L |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2018 |
| Project Title: | Federation of Immunological Societies of Asia Oceania 7th Congress 2018 (FIMSA 2018); γδ T cells protect against lung infection by promoting plasmacytic differentiation of B-1a cells via an interleukin-17A-dependent mechanism |
| Investigator(s): | Wang X |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2018 |
| Completion Date: | 11/2018 |
| List of Research Outputs |
| Lin X., Wang X., Xiao F., Ma K., Liu L., Wang X., Xu D., Wang F., Shi X., Liu D., Zhao Y. and Lu L., IL-10-producing regulatory B cells restrain the T follicular helper cell response in primary Sjögren’s syndrome, Cellular & Molecular Immunology. 2019. |
| Tian J., Rui K., Hong Y., Wang X., Xiao F., Lin X., Ma J., Guo H., Xu H., Ma K., Xu D., Liu D., Zhao Y., Lu L. and Wang S., Increased GITRL Impairs the Function of Myeloid-Derived Suppressor Cells and Exacerbates Primary Sjögren Syndrome, The Journal of Immunology. 2019, 202: 1693-1703. |
| Wang X., Cong Y., Lin X., Ma K., Xiao F., Dong L. and Lu L., New insights into the significance of the BCR repertoire in B-1 cell development and function, Cellular & Molecular Immunology. 2019. |
| Wu H., Deng Y., Feng Y., Long D., Ma K., Wang X., Zhao M., Lu L. and Lu Q., Epigenetic regulation in B-cell maturation and its dysregulation in autoimmunity, Cellular & Molecular Immunology. 2018, 15: 676-684. |
| Researcher : Wei L |
| List of Research Outputs |
| Tsang F.H., LAW C.T., Tang T.C.C., Cheng C.L., Chin D.W., Tam W.S.V., Wei L., Wong C.C.L., Ng I.O.L. and Wong C.M., Aberrant super-enhancer landscape in human hepatocellular carcinoma, Hepatology. 2019. |
| Researcher : Wong CCL |
| Project Title: | Targeting the metabolic machineries of HCC by understanding the roles of transketolase in hepatocellular carcinoma development |
| Investigator(s): | Wong CCL, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 08/2015 |
| Project Title: | The molecular mechanisms of hypoxia-induced myeloid-derived suppressor cell (MDSC) recruitment in liver cancer |
| Investigator(s): | Wong CCL, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2015 |
| Completion Date: | 08/2018 |
| Project Title: | The molecular mechanisms elicited by Sorafenib withdrawal in hepatocellular carcinoma treatment |
| Investigator(s): | Wong CCL, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2016 |
| Completion Date: | 07/2019 |
| Project Title: | Targeting hypoxia-induced ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2) in hepatocellular carcinoma (HCC) development |
| Investigator(s): | Wong CCL, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2016 |
| Completion Date: | 01/2019 |
| Project Title: | Identifying the Metabolic Vulnerabilities of Liver Cancer |
| Investigator(s): | Wong CCL |
| Department: | Pathology |
| Source(s) of Funding: | Croucher Innovation Awards |
| Start Date: | 06/2016 |
| Project Title: | Clinical significance and metabolic roles of methylenetetrahydrofolate dehydrogenase 1-Like (MTHFD1L) in liver cancer development |
| Investigator(s): | Wong CCL, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2017 |
| Project Title: | New therapeutic strategies involving TXNRD1 inhibitor in HCC treatment |
| Investigator(s): | Wong CCL, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| Completion Date: | 05/2019 |
| Project Title: | Characterization of a novel tumor suppressive long non-coding RNA linc-ALDH1A2-1 in hepatocellular carcinoma |
| Investigator(s): | Wong CCL, Wong CM, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 08/2017 |
| Project Title: | The molecular regulations, roles, and clinical implications of hypoxia-induced porcupine in hepatocellular carcinoma |
| Investigator(s): | Wong CCL, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2018 |
| Project Title: | Outstanding Young Researcher Award 2016-17 |
| Investigator(s): | Wong CCL |
| Department: | Pathology |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 01/2018 |
| Project Title: | Translational Immunometabolism; Repurposing auranofin, a thioredoxin reductase 1 (TXNRD1) inhibitor and an anti-rheumatic agent, for hepatocellular carcinoma (HCC) treatment |
| Investigator(s): | Wong CCL |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2018 |
| Project Title: | Pathological roles of Bromodomain and Extra-Terminal (BET) proteins and their therapeutic implications in liver cancer |
| Investigator(s): | Wong CCL, Ng IOL, Wong CM |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2018 |
| Project Title: | Molecular regulations and mechanistic functions of hypoxia-induced macropinocytosis in hepatocellular carcinoma. |
| Investigator(s): | Wong CCL, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2019 |
| Project Title: | Targeting hepatocellular carcinoma metabolism through blockade of BRD4-associated super-enhancers |
| Investigator(s): | Wong CCL |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2019 |
| Project Title: | Oncometabolite production in hepatocellular carcinoma: from regulations, molecular consequences, to clinical implications (CRF) |
| Investigator(s): | Wong CCL |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding for Strategic Interdisciplinary Research Scheme |
| Start Date: | 06/2019 |
| List of Research Outputs |
| Law C.T., Tsang F.H., Chan C.Y., XU M., Lai R.K., Ho D.W.H., Lee J.K.M., Wong C.C.L., Ng I.O.L. and Wong C.M., Chromatin remodeler HELLS is an epigenetic driver for hepatocellular carcinoma progression. , Hepatology . 2019. |
| Lee D., XU M., CHIU K.C., Leibold J., Tse P.W., Bao H.R., Yuen W.H., Chan Y.K., LAI K.H., Chin W.C., Chan F.F., Cheung T.T., Chok K.S.H., Wong C.M., Lowe S.W., Ng I.O.L. and Wong C.C.L., Induction of oxidative stress through inhibition of thioredoxin reductase 1 is an effective therapeutic approach for hepatocellular carcinoma, Hepatology. 2019, 69: 1768-1786. |
| Tsang F.H., LAW C.T., Tang T.C.C., Cheng C.L., Chin D.W., Tam W.S.V., Wei L., Wong C.C.L., Ng I.O.L. and Wong C.M., Aberrant super-enhancer landscape in human hepatocellular carcinoma, Hepatology. 2019. |
| Wong C.C.L., Ng I.O.L. and Lo C.L.R., Faculty Outstanding Research Output Award, Faculty of Medicine, The University of Hong Kong. 2019. |
| Wong C.C.L., Junior Investigator Award, International Liver Cancer Association . 2019. |
| Researcher : Wong CL |
| Project Title: | Targeting the metabolic machineries of HCC by understanding the roles of transketolase in hepatocellular carcinoma development |
| Investigator(s): | Wong CCL, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 08/2015 |
| Project Title: | The molecular mechanisms of hypoxia-induced myeloid-derived suppressor cell (MDSC) recruitment in liver cancer |
| Investigator(s): | Wong CCL, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2015 |
| Completion Date: | 08/2018 |
| Project Title: | The molecular mechanisms elicited by Sorafenib withdrawal in hepatocellular carcinoma treatment |
| Investigator(s): | Wong CCL, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2016 |
| Completion Date: | 07/2019 |
| Project Title: | Targeting hypoxia-induced ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2) in hepatocellular carcinoma (HCC) development |
| Investigator(s): | Wong CCL, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2016 |
| Completion Date: | 01/2019 |
| Project Title: | Identifying the Metabolic Vulnerabilities of Liver Cancer |
| Investigator(s): | Wong CCL |
| Department: | Pathology |
| Source(s) of Funding: | Croucher Innovation Awards |
| Start Date: | 06/2016 |
| Project Title: | Clinical significance and metabolic roles of methylenetetrahydrofolate dehydrogenase 1-Like (MTHFD1L) in liver cancer development |
| Investigator(s): | Wong CCL, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2017 |
| Project Title: | New therapeutic strategies involving TXNRD1 inhibitor in HCC treatment |
| Investigator(s): | Wong CCL, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| Completion Date: | 05/2019 |
| Project Title: | Characterization of a novel tumor suppressive long non-coding RNA linc-ALDH1A2-1 in hepatocellular carcinoma |
| Investigator(s): | Wong CCL, Wong CM, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 08/2017 |
| Project Title: | The molecular regulations, roles, and clinical implications of hypoxia-induced porcupine in hepatocellular carcinoma |
| Investigator(s): | Wong CCL, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2018 |
| Project Title: | Outstanding Young Researcher Award 2016-17 |
| Investigator(s): | Wong CCL |
| Department: | Pathology |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 01/2018 |
| Project Title: | Translational Immunometabolism; Repurposing auranofin, a thioredoxin reductase 1 (TXNRD1) inhibitor and an anti-rheumatic agent, for hepatocellular carcinoma (HCC) treatment |
| Investigator(s): | Wong CCL |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2018 |
| Project Title: | Pathological roles of Bromodomain and Extra-Terminal (BET) proteins and their therapeutic implications in liver cancer |
| Investigator(s): | Wong CCL, Ng IOL, Wong CM |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2018 |
| Project Title: | Molecular regulations and mechanistic functions of hypoxia-induced macropinocytosis in hepatocellular carcinoma. |
| Investigator(s): | Wong CCL, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2019 |
| Project Title: | Targeting hepatocellular carcinoma metabolism through blockade of BRD4-associated super-enhancers |
| Investigator(s): | Wong CCL |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2019 |
| Project Title: | Oncometabolite production in hepatocellular carcinoma: from regulations, molecular consequences, to clinical implications (CRF) |
| Investigator(s): | Wong CCL |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding for Strategic Interdisciplinary Research Scheme |
| Start Date: | 06/2019 |
| List of Research Outputs |
| Researcher : Wong CM |
| Project Title: | Pathological roles of chromatin remodeling protein, HELLS, in liver carcinogenesis and its implications in cancer metabolic reprogramming |
| Investigator(s): | Wong CM |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2015 |
| Project Title: | Clinicopathological significance and functional roles of G9a up-regulation in Hepatocellular Carcinoma |
| Investigator(s): | Wong CM, Wong CCL, Tsang FH |
| Department: | Pathology |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2016 |
| Project Title: | Deregulation and somatic mutations of histone methyltransferase ASH1L in liver cancer. |
| Investigator(s): | Wong CM, Tsang FH, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2016 |
| Project Title: | Pathological implications and functional characterizations of novel long non-coding RNA linc-CHD1L-1 in hepatocellular carcinoma |
| Investigator(s): | Wong CM, Tsang FH, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2016 |
| Completion Date: | 09/2019 |
| Project Title: | Deregulation and pathological implications of RNA N6-adensoine methyltransferase METTL3 in liver carcinogenesis |
| Investigator(s): | Wong CM, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 03/2017 |
| Project Title: | The roles of bromodomain containing proteins in liver carcinogenesis |
| Investigator(s): | Wong CM, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2017 |
| Completion Date: | 02/2019 |
| Project Title: | Therapeutic potential of targeting CDK7-dependent and super-enhancer associated oncogene addiction in liver cancer |
| Investigator(s): | Wong CM, Tsang FH, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2017 |
| Project Title: | Pathological significances and therapeutic potential of targeting FACT complex in liver cancer |
| Investigator(s): | Wong CM, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2018 |
| Project Title: | 12th Annual Conference of the International Liver Cancer Association ; Genome-wide CRISPR/Cas9 library screening identified PHGDH and serine pathway as a critical driver for tyrosine kinase inhibitors resistance in HCC |
| Investigator(s): | Wong CM |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2018 |
| Project Title: | Genome-scale CRISPR/Cas9 knockout library screening identified druggable targets to overcome Lenvatinib resistance in liver cancer |
| Investigator(s): | Wong CM, Wei L |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2019 |
| Project Title: | Characterization of a super-enhancer associated oncogenic long non-coding RNA LINC00511 in hepatocellular carcinoma |
| Investigator(s): | Wong CM, Tsang FH |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2019 |
| List of Research Outputs |
| Law C.T., Tsang F.H., Chan C.Y., XU M., Lai R.K., Ho D.W.H., Lee J.K.M., Wong C.C.L., Ng I.O.L. and Wong C.M., Chromatin remodeler HELLS is an epigenetic driver for hepatocellular carcinoma progression. , Hepatology . 2019. |
| Lee D., XU M., CHIU K.C., Leibold J., Tse P.W., Bao H.R., Yuen W.H., Chan Y.K., LAI K.H., Chin W.C., Chan F.F., Cheung T.T., Chok K.S.H., Wong C.M., Lowe S.W., Ng I.O.L. and Wong C.C.L., Induction of oxidative stress through inhibition of thioredoxin reductase 1 is an effective therapeutic approach for hepatocellular carcinoma, Hepatology. 2019, 69: 1768-1786. |
| TAN H.W., Leung C.O., Chan K.K., Ho D.W.H., Leung M.S., Wong C.M., Ng I.O.L. and Lo C.L.R., Deregulated GATA6 modulates stem cell-like properties and metabolic phenotype in hepatocellular carcinoma, Int J Cancer. 2019. |
| TAN H.W., LEUNG O.N., Chan K.S., Ho D.W.H., LEUNG M.S., Wong C.M., Ng I.O.L. and Lo C.L.R., Deregulated Gata6 Modulates Stem Cell‐like Properties And Metabolic Phenotype In Hepatocellular Carcinoma, International Journal Of Cancer. 2019, 145: 1860-1873. |
| Tsang F.H., LAW C.T., Tang T.C.C., Cheng C.L., Chin D.W., Tam W.S.V., Wei L., Wong C.C.L., Ng I.O.L. and Wong C.M., Aberrant super-enhancer landscape in human hepatocellular carcinoma, Hepatology. 2019. |
| Researcher : Wong ESY |
| List of Research Outputs |
| LI X., Mak C.Y., Zhou Y., Chao W., Wong E.S.Y., Sharma R., Lu Y., Cheung A.N.Y., Mills G.B. and Cheung W.T.L., Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer, Nature Communications. 2019, 10: 716. |
| Researcher : Wong GW |
| Project Title: | Targeting Human papillomavirus (HPV) negative cervical cancer |
| Investigator(s): | Wong GW, Cheung ANY, Ngan HYS, Liu S |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2018 |
| List of Research Outputs |
| CHEN L., Wong G.W., Wong T.L.I., Wang J. and Cheung A.N.Y., Aberrant Expression of ROS1 is Uncommon in Ovarian Cancer, In: Chen L, Wong OGW, Wong ITL, Wang J, Cheung AN., AACR New Horizons in Cancer Research Conference. May 3-5, 2019, Shenzhen, China.. 2019. |
| Ip P.C.P., Wang S.Y., Wong G.W., Chow K.L., Lee H.Y.H., Cheung A.N.Y. and Tse K.Y., Napsin A, Hepatocyte Nuclear Factor-1-Beta (HNF-1β), Estrogen and Progesterone Receptors Expression in Arias-Stella Reaction, The American Journal of Surgical Pathology. 2019, 43: 325-333. |
| Wong G.W., Cheung L.Y., Ip P.C.P., Ngan H.Y.S. and Cheung A.N.Y., Amyloid Precursor Protein Overexpression in Down Syndrome Trophoblast Reduces Cell Invasiveness and Interferes with Syncytialization., American Journal of Pathology. 2018, 188: 2307-2317. |
| Wong G.W., Tsun O.K.L., Tsui E.Y., Chow N.K., Ip P.C.P. and Cheung A.N.Y., HPV genotyping and E6/E7 transcript assays for cervical lesion detection in an Asian screening population—Cobas and Aptima HPV tests, Journal of Clinical Virology. 2018, 109: 13-18. |
| Wong G.W., Cheung L.Y., Liu S., Ngan H.Y.S. and Cheung A.N.Y., Multiple alterations on genes encoding components of the SWItch/Sucrose Non-Fermentable complex could be found in human papillomavirus-negative cervical cancer. , In: Wong OGW, Cheung CLY, Liu SS, Ngan HYS, Cheung AN., AACR New Horizons in Cancer Research Conference. May 3-5, 2019, Shenzhen, China.. 2019. |
| Wong T.L.I., Wong G.W. and Cheung A.N.Y., Nuclear PAK4 impairs homologous recombination via RAD51C to promote genome instability in high-grade serous ovarian cancer., In: Wong ITL, Wong OGW, Cheung AN., AACR New Horizons in Cancer Research Conference. May 3-5, 2019, Shenzhen, China.. 2019. |
| Researcher : Wong M.P. |
| Project Title: | Mutational Analysis of Epidermal Growth Factor Receptor in Non-Small Cell Lung Cancer |
| Investigator(s): | Wong MP, Chua DTT |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2005 |
| Project Title: | p38 MAPK in human lung cancers and its involvement in treatment resistance to tyrosine kinase inhibitors |
| Investigator(s): | Wong MP, Leung LH |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 02/2011 |
| Project Title: | Translating intra-tumoural genetic heterogeneity to identify cancer progression genes in lung adenocarcinoma |
| Investigator(s): | Wong MP, Wang JJ, Sham PC, Lee VHF, Lee EYP, Fong DYT |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2016 |
| Project Title: | The role and mechanisms of CaMK2A/SOX2 coupling in tumor initiating cells regulation and drug resistance in non-small cell lung cancer |
| Investigator(s): | Wong MP, Yam JWP |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 07/2016 |
| Project Title: | SOX2/ALDH1A1 coupling and chemo-resistance of non-small cell lung cancer |
| Investigator(s): | Wong MP, Yam JWP, Xiao Z |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2017 |
| Completion Date: | 04/2019 |
| Project Title: | Harnessing tyrosine kinase inhibitor resistance of EGFR-mutated lung adenocarcinomas through candidate resistant genes screening |
| Investigator(s): | Wong MP, Ho JCM, Xiao Z, So JCC, Sham PC |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2018 |
| Project Title: | Galectin-9 is a potential dual treatment target for tumor cells and the immune micro-environment of lung adenocarcinoma |
| Investigator(s): | Wong MP, Xiao Z, Yam JWP |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2019 |
| List of Research Outputs |
| Researcher : Wong MP |
| Project Title: | Mutational Analysis of Epidermal Growth Factor Receptor in Non-Small Cell Lung Cancer |
| Investigator(s): | Wong MP, Chua DTT |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2005 |
| Project Title: | p38 MAPK in human lung cancers and its involvement in treatment resistance to tyrosine kinase inhibitors |
| Investigator(s): | Wong MP, Leung LH |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 02/2011 |
| Project Title: | Translating intra-tumoural genetic heterogeneity to identify cancer progression genes in lung adenocarcinoma |
| Investigator(s): | Wong MP, Wang JJ, Sham PC, Lee VHF, Lee EYP, Fong DYT |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2016 |
| Project Title: | The role and mechanisms of CaMK2A/SOX2 coupling in tumor initiating cells regulation and drug resistance in non-small cell lung cancer |
| Investigator(s): | Wong MP, Yam JWP |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 07/2016 |
| Project Title: | SOX2/ALDH1A1 coupling and chemo-resistance of non-small cell lung cancer |
| Investigator(s): | Wong MP, Yam JWP, Xiao Z |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2017 |
| Completion Date: | 04/2019 |
| Project Title: | Harnessing tyrosine kinase inhibitor resistance of EGFR-mutated lung adenocarcinomas through candidate resistant genes screening |
| Investigator(s): | Wong MP, Ho JCM, Xiao Z, So JCC, Sham PC |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2018 |
| Project Title: | Galectin-9 is a potential dual treatment target for tumor cells and the immune micro-environment of lung adenocarcinoma |
| Investigator(s): | Wong MP, Xiao Z, Yam JWP |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2019 |
| List of Research Outputs |
| Wong M.P., Xiao Z., Tin P.C. and Ho J.C.M., Uncovering Tyrosine Kinase Inhibitor Resistance Mutations In EGFR Mutant Lung Adenocarcinoma Using Whole Exome Sequencing, Cancer Genomics Conference. 2019. |
| Researcher : Wong TLI |
| List of Research Outputs |
| CHEN L., Wong G.W., Wong T.L.I., Wang J. and Cheung A.N.Y., Aberrant Expression of ROS1 is Uncommon in Ovarian Cancer, In: Chen L, Wong OGW, Wong ITL, Wang J, Cheung AN., AACR New Horizons in Cancer Research Conference. May 3-5, 2019, Shenzhen, China.. 2019. |
| Wong T.L.I., Wong G.W. and Cheung A.N.Y., Nuclear PAK4 impairs homologous recombination via RAD51C to promote genome instability in high-grade serous ovarian cancer., In: Wong ITL, Wong OGW, Cheung AN., AACR New Horizons in Cancer Research Conference. May 3-5, 2019, Shenzhen, China.. 2019. |
| Researcher : XU M |
| List of Research Outputs |
| Law C.T., Tsang F.H., Chan C.Y., XU M., Lai R.K., Ho D.W.H., Lee J.K.M., Wong C.C.L., Ng I.O.L. and Wong C.M., Chromatin remodeler HELLS is an epigenetic driver for hepatocellular carcinoma progression. , Hepatology . 2019. |
| Lee D., XU M., CHIU K.C., Leibold J., Tse P.W., Bao H.R., Yuen W.H., Chan Y.K., LAI K.H., Chin W.C., Chan F.F., Cheung T.T., Chok K.S.H., Wong C.M., Lowe S.W., Ng I.O.L. and Wong C.C.L., Induction of oxidative stress through inhibition of thioredoxin reductase 1 is an effective therapeutic approach for hepatocellular carcinoma, Hepatology. 2019, 69: 1768-1786. |
| Researcher : Xiao F |
| List of Research Outputs |
| Guggino G., Lin X., Rizzo A., Xiao F., Saieva L., Raimondo S., Di Liberto D., Candore G., Ruscitti P., Cipriani P., Giacomelli R., Dieli F., Alessandro R., Triolo G., Lu L. and Ciccia F., Interleukin-25 Axis Is Involved in the Pathogenesis of Human Primary and Experimental Murine Sjögren's Syndrome, Arthritis & Rheumatology. 2018, 70: 1265-1275. |
| Lin X., Wang X., Xiao F., Ma K., Liu L., Wang X., Xu D., Wang F., Shi X., Liu D., Zhao Y. and Lu L., IL-10-producing regulatory B cells restrain the T follicular helper cell response in primary Sjögren’s syndrome, Cellular & Molecular Immunology. 2019. |
| Tian J., Rui K., Hong Y., Wang X., Xiao F., Lin X., Ma J., Guo H., Xu H., Ma K., Xu D., Liu D., Zhao Y., Lu L. and Wang S., Increased GITRL Impairs the Function of Myeloid-Derived Suppressor Cells and Exacerbates Primary Sjögren Syndrome, The Journal of Immunology. 2019, 202: 1693-1703. |
| Wang X., Cong Y., Lin X., Ma K., Xiao F., Dong L. and Lu L., New insights into the significance of the BCR repertoire in B-1 cell development and function, Cellular & Molecular Immunology. 2019. |
| Researcher : Xiao Z |
| List of Research Outputs |
| Wong M.P., Xiao Z., Tin P.C. and Ho J.C.M., Uncovering Tyrosine Kinase Inhibitor Resistance Mutations In EGFR Mutant Lung Adenocarcinoma Using Whole Exome Sequencing, Cancer Genomics Conference. 2019. |
| Researcher : YU Y |
| List of Research Outputs |
| YU Y., Chow K.L., Lee H.Y.H., Cheuk W., Cheung E.T.Y., Chan W.K., Lee V.W.K., Cheung A.N.Y., Tse K.Y. and Ip P.C.P., Evaluation of potential immunotherapy biomarkers in female genital tract malignant melanomas, 108th Annual meeting of The United States and Canadian Academy of Pathology.. Modern Pathology, 2019, 134. |
| YU Y., Ip P.C.P. and Cheung A.N.Y., Molecular Mechanisms and Therapeutic Targets in Genital tract Malignant Melanomas, The University of Hong Kong. Hong Kong, The University of Hong Kong, 2018. |
| Researcher : Yam JWP |
| Project Title: | Outstanding Young Researcher Award 2008-2009 |
| Investigator(s): | Yam JWP |
| Department: | Pathology |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 12/2009 |
| Project Title: | Role of caveolim-1 in hepatitis B virus-induced hepatocarcinogenesis |
| Investigator(s): | Yam JWP, Guan X |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 11/2013 |
| Project Title: | Functional role of hypoxia-induced caveolin-1 in hepatocellular carcinoma metastasis |
| Investigator(s): | Yam JWP |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 08/2015 |
| Project Title: | Functional role of caveolin-1-mediated S100P in liver cancer metastasis under hypoxic stress |
| Investigator(s): | Yam JWP |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Completion Date: | 12/2018 |
| Project Title: | Exosomes released from nuclear Met expressing cells promote liver cancer metastasis and formation of lung premetastatic niche |
| Investigator(s): | Yam JWP, Wong AST |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2017 |
| Project Title: | Application of S100P antibody as a strategy for the treatment of liver cancer |
| Investigator(s): | Yam JWP, Ching YP |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 06/2017 |
| Project Title: | The interplay of Rab20 and Sec23A in the biological activities of exosomes in liver cancer |
| Investigator(s): | Yam JWP, Lo CLR |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| Completion Date: | 06/2019 |
| Project Title: | Downregulation of medium chain acyl-CoA dehydrogenase in liver cancer: Functional outcome and clinical relevance |
| Investigator(s): | Yam JWP, Wong CCL |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2018 |
| Project Title: | Application of antibody specifically target cancer-bound CFH as a therapeutic strategy for liver cancer |
| Investigator(s): | Yam JWP |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 06/2018 |
| Project Title: | Suppression of fatty acid oxidation by caveolin-1 contributes to hepatocellular carcinoma progression |
| Investigator(s): | Yam JWP, Wong CCL |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2018 |
| Project Title: | 8th Congress of the International Society for Extracellular Vesicles (ISEV2019); Exosomal nidogen 1 drives liver cancer metastasis by inducing secretion of tumor necrosis factor receptor 1 from activated lung fibroblasts |
| Investigator(s): | Yam JWP |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2019 |
| Completion Date: | 04/2019 |
| Project Title: | Exosomes derived from metastatic liver cancer cells facilitate pre-metastatic niche formation by inducing activation of pulmonary fibroblast |
| Investigator(s): | Yam JWP, Wong AST |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2019 |
| Project Title: | Role of Exosomes in Liver Cancer Metastasis: From Basic Research to Clinical Applications (CRF) |
| Investigator(s): | Yam JWP |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding for Strategic Interdisciplinary Research Scheme |
| Start Date: | 06/2019 |
| List of Research Outputs |
| MA P.Y. and Yam J.W.P., Suppression of fatty acid oxidation by caveolin-1 contributes to hepatocellular carcinoma progression, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019. |
| Mao X., Tey S.K., Ko F.C.F., Kwong M.L., Goa Y., Ng I.O.L., Cheung S.T., Guan X. and Yam J.W.P., C-terminal truncated HBx protein activates caveolin-1/LRP6/β-catenin/FRMD5 axis in promoting hepatocarcinogenesis, Cancer Letters. 2019, 444: 60-69. |
| Mao X., Tey S.K. and Yam J.W.P., Exosomal nidogen 1 drives liver cancer metastasis by inducing secretion of tumor necrosis factor receptor 1 from activated lung fibroblasts, ISEV (The International Society for Extracellular Vesicles) 2019 Annual meeting. 2019. |
| Mao X., Ko F.C.F., Tey S.K., Man K., Lo C.L.R., Ng I.O.L. and Yam J.W.P., Hypoxia-induced caveolin-1 drives tumorigenesis and metastasis by activation of NF-κB/S100P pathway in hepatocellular carcinoma, Health Research Symposium 2019. |
| Tey S.K. and Yam J.W.P., Patient-derived circulating exosomes enhance cancer and stemness properties through polymeric immunoglobulin receptor in liver cancer, ISEV (The International Society for Extracellular Vesicles) 2019 Annual meeting. 2019. |
| Yam J.W.P., Exosomes in liver cancer: Functional role and clinical relevance, Pathology 100th Anniversary & Hong Kong Pathology Forum 2019. 2019. |
| Yam J.W.P., Review paper, Hepatology. 2018. |
| Researcher : Yan HHN |
| Project Title: | Intestinal organoid cultures of early onset colorectal cancers |
| Investigator(s): | Yan HHN, Leung SY, Law WL |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2015 |
| Project Title: | Characterization of gastric intestinal metaplasia and its role in gastric cancer progression |
| Investigator(s): | Yan HHN, Leung SY |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2016 |
| Project Title: | Use of whole genome sequencing to unveil new mechanisms of germline DNA mismatch repair gene alterations in Lynch Syndrome patients |
| Investigator(s): | Yan HHN, Leung SY, Siu HC |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2017 |
| List of Research Outputs |
| CHAN L.H., Zhou L., Ng K.Y., Wong T.L., Lee T.K., Sharma R., LOONG H.C., Ching Y.P., Yuan Y.F., Xie D., Lo C.M., Man K., Artegiani B., Clevers H., Yan H.H.N., Leung S.Y., Richard S., Guan X., Huen M.S.Y. and Ma S.K.Y., Protein arginine methyltransferase PRMT6 regulates RAS/RAF binding and MEK/ERK-mediated cancer stemness activities in hepatocellular carcinoma through CRAF methylation, Cell Reports. 2018. |
| Chan A.S., Yan H.H.N. and Leung S.Y., Breakthrough Moments: Organoid Models of Cancer, Cell Stem Cell. 2019, 24: 839-840. |
| Yan H.H.N., Siu H.C., Law S.Y.K., Ho R.S.L., Yue S.K.S., Tsui W.Y., Chan D., Chan A.S., Ma S.K.Y., Lam K.O., Bartfeld S., Man H.Y., Lee C.H., Chan A.S.Y., Wong W.H.J., Cheng S.W.P., Chan K.W., Zhang J., Shi J., Fan X., Kwong D.L.W., Mak T.W., Yuen S.T., Clevers H. and Leung S.Y., A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening, Cell Stem Cell. 2018. |
| Yan H.H.N., Chan D., Siu H.C., Law S.Y.K., Ho R.S.L., Tsui W.Y., Yue S.K.S., Chan A.S., Lee C.H., Chan A.S.Y., Chan K.W., Leung H.C., Hui H.S., Lam K.O., Kwong D.L.W., Mak T.W., Clevers H. and Leung S.Y., Establishment of a large-scale drug sensitivity screening platform on gastric cancer organoid cultures with potential to guide treatment. , American Association for Cancer Research (AACR) and Korean Cancer Association (KCA) Joint Conference on Precision Medicine in Solid Tumors. 2018. |
| Yan H.H.N., Travel Award , American Association for Cancer Research (AACR) and Korean Cancer Association (KCA) Joint Conference on Precision Medicine in Solid Tumors 2018. 2018. |
| Researcher : Yau TO |
| Project Title: | The role of Frizzled-7, receptor of the WNT/β-catenin signalling pathway, in hepatocellular carcinoma: Implications in tumorigenesis and metastasis |
| Investigator(s): | Yau TO, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2006 |
| Researcher : Yue SKS |
| List of Research Outputs |
| Yan H.H.N., Siu H.C., Law S.Y.K., Ho R.S.L., Yue S.K.S., Tsui W.Y., Chan D., Chan A.S., Ma S.K.Y., Lam K.O., Bartfeld S., Man H.Y., Lee C.H., Chan A.S.Y., Wong W.H.J., Cheng S.W.P., Chan K.W., Zhang J., Shi J., Fan X., Kwong D.L.W., Mak T.W., Yuen S.T., Clevers H. and Leung S.Y., A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening, Cell Stem Cell. 2018. |
| Yan H.H.N., Chan D., Siu H.C., Law S.Y.K., Ho R.S.L., Tsui W.Y., Yue S.K.S., Chan A.S., Lee C.H., Chan A.S.Y., Chan K.W., Leung H.C., Hui H.S., Lam K.O., Kwong D.L.W., Mak T.W., Clevers H. and Leung S.Y., Establishment of a large-scale drug sensitivity screening platform on gastric cancer organoid cultures with potential to guide treatment. , American Association for Cancer Research (AACR) and Korean Cancer Association (KCA) Joint Conference on Precision Medicine in Solid Tumors. 2018. |
| Researcher : Yuen ST |
| List of Research Outputs |
| Yan H.H.N., Siu H.C., Law S.Y.K., Ho R.S.L., Yue S.K.S., Tsui W.Y., Chan D., Chan A.S., Ma S.K.Y., Lam K.O., Bartfeld S., Man H.Y., Lee C.H., Chan A.S.Y., Wong W.H.J., Cheng S.W.P., Chan K.W., Zhang J., Shi J., Fan X., Kwong D.L.W., Mak T.W., Yuen S.T., Clevers H. and Leung S.Y., A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening, Cell Stem Cell. 2018. |
| Researcher : Yuen WH |
| List of Research Outputs |
| Lee D., XU M., CHIU K.C., Leibold J., Tse P.W., Bao H.R., Yuen W.H., Chan Y.K., LAI K.H., Chin W.C., Chan F.F., Cheung T.T., Chok K.S.H., Wong C.M., Lowe S.W., Ng I.O.L. and Wong C.C.L., Induction of oxidative stress through inhibition of thioredoxin reductase 1 is an effective therapeutic approach for hepatocellular carcinoma, Hepatology. 2019, 69: 1768-1786. |
| Researcher : Zhang X |
| List of Research Outputs |
| Zhao L., Chan L.K., Ho D.W.H., Tsui Y.M., Sze M.F., Zhang X., Lee M.F. and Ng I.O.L., RalA is frequently up-regulated in human hepatocellular carcinoma and promotes metastasis and cancer stemness, AACR (American Association for Cancer Research) Annual Meeting 2018. |
| Researcher : Zhao F |
| Project Title: | Role of hyperpolarization-activated cyclic nucleotide-gated channel 2 (HCN2) in breast cancer tumorigenesis |
| Investigator(s): | Zhao F, Khoo US |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2015 |
| Researcher : Zhao L |
| List of Research Outputs |
| Zhao L., Chan L.K., Ho D.W.H., Tsui Y.M., Sze M.F., Zhang X., Lee M.F. and Ng I.O.L., RalA is frequently up-regulated in human hepatocellular carcinoma and promotes metastasis and cancer stemness, AACR (American Association for Cancer Research) Annual Meeting 2018. |