CENTRE FOR PANOROMIC SCIENCES
| Researcher : Baum LW |
| List of Research Outputs |
| International League Against Epilepsy Consortium on Complex Epilepsies and Baum L.W., Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies, Nature Communications. 2018, 9. |
| Lee C.H., Tse B., Lai N., Goggins W., Baum L.W. and Nelson E.A.S., Hong Kong’s role in global health: Public opinion of official development assistance, PLOS ONE. 2018, 13: e0207687. |
| Yu K.C., Kwan P., Cheung S.K.K., Ho A. and Baum L.W., Effects of resveratrol and morin on soluble and insoluble hyperphosphorylated tau in a transgenic mouse model of tauopathy, Translational Neuroscience. 2018, 9: 54-60. |
| Researcher : Fan Y |
| List of Research Outputs |
| Takeda K., Kou I., Otomo N., Grauers N., Fan Y., Ogura Y., Takahashi Y., Momozawa Y., Einarsdottir E., Kere J., Matsumoto M., Qiu Y., Song Y., Gerdhem P., Watanabe K. and Ikegawa S., A multiethnic meta-analysis defined the association of rs12946942 with severe adolescent idiopathic scoliosis, Journal of Human Genetics. 2019, 64: 493-498. |
| Researcher : Jiang L |
| List of Research Outputs |
| Li M., Jiang L., Mak S.H.T., Kwan S.H., Xue C., Chen P., Leung H.C.M., Cui L., Li T. and Sham P.C., A powerful conditional gene-based association approach implicated functionally important genes for schizophrenia, Bioinformatics. 2018, bty682. |
| Researcher : Kwok H |
| List of Research Outputs |
| Lin W., Yip Y.L., Jia L.J., Deng W., Zheng H., Dai W., Ko J.M.Y., Lo K.W., Chung G.T.Y., Yip K.Y., Lee S.D., Kwan J.S.H., Zhang J., Liu T.F., Chan Y.W., Kwong D.L.W., Lee V.H.F., Nicholls J.M., Busson P., Liu X.F., Chiang A.K.S., Hui K.F., Kwok H., Cheung S.T., Cheung Y.C., Chan C.K., Li B., Cheung A., Hau P.M., Zhou Y., Tsang C.M., Middeldorp J., Chen H., Lung M.L. and Tsao G.S.W., Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma, Nature Communications. 2018, 7; 9(1): 4663. |
| Researcher : Li J |
| List of Research Outputs |
| YAO H., Sham P.C. and Li J., Identification of GWAS causal tissue, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018. |
| Researcher : Mak SHT |
| List of Research Outputs |
| Li M., Jiang L., Mak S.H.T., Kwan S.H., Xue C., Chen P., Leung H.C.M., Cui L., Li T. and Sham P.C., A powerful conditional gene-based association approach implicated functionally important genes for schizophrenia, Bioinformatics. 2018, bty682. |
| Porsch R.M., Mak S.H.T. and Sham P.C., KS-Burden: Assessing distributional differences of rare variants in dichotomous traits, Cold Spring Harbor Laboratory, 2018. |
| Zhou X., Cheung C.L., Karasugi T., Karppinen J., Samartzis D., Hsu Y.H., Mak S.H.T., Song Y., Chiba K., Kawaguchi Y., LI Y., Chan D., Cheung K.M.C., Ikegawa S., Cheah K.S.E. and Sham P.C., Trans-ethnic polygenic analysis supports genetic overlap of lumbar disc degeneration with height, body mass index, and bone mineral density., Frontiers in Genetics. 2018. |
| Researcher : Porsch RM |
| List of Research Outputs |
| Porsch R.M., Mak S.H.T. and Sham P.C., KS-Burden: Assessing distributional differences of rare variants in dichotomous traits, Cold Spring Harbor Laboratory, 2018. |
| Researcher : Sham PC |
| Project Title: | Replication study of susceptibility genes for colorectal cancer |
| Investigator(s): | Sham PC, Ho JWC, Cheng KK |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2007 |
| Project Title: | Partner State Key Laboratory of Brain and Cognitive Sciences |
| Investigator(s): | Sham PC, So KF, Tan L |
| Department: | Centre for PanorOmic Sciences |
| Source(s) of Funding: | Matching Fund for State Key Laboratory (SKL) |
| Start Date: | 10/2008 |
| Project Title: | Visiting Research Professors Scheme 2009-10 |
| Investigator(s): | Sham PC |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Visiting Research Professors Scheme |
| Start Date: | 09/2009 |
| Project Title: | Genomics |
| Investigator(s): | Sham PC, Chin FYL, Leung FCC |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 06/2013 |
| Project Title: | Schizophrenia-related de novo and compound heterozygous mutations |
| Investigator(s): | Sham PC, Chen EYH, Chang WC, Chan KW, Lee HME, Cherny SS, Li M |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2015 |
| Completion Date: | 12/2018 |
| Project Title: | Method and software tool for estimating and dissecting the heritability of complex diseases |
| Investigator(s): | Sham PC, Cherny SS, Li M |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2015 |
| Completion Date: | 10/2018 |
| Project Title: | Establishment of Third Generation Sequencing Core Facility |
| Investigator(s): | Sham PC, Leung SY, Peiris JSM, Poon LML, Woo PCY, Yuen KY |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Major Equipment Project |
| Start Date: | 04/2017 |
| Project Title: | Genetic Variation and Genomic Architecture in Development, Health and Disease |
| Investigator(s): | Sham PC |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Croucher Advanced Study Institute |
| Start Date: | 12/2017 |
| Project Title: | Integrating functional annotation and statistical information in novel set-based rare-variants association tests for complex diseases |
| Investigator(s): | Sham PC, Cherny SS, Li M, Tang SM |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2018 |
| Project Title: | New-generation high-performance computer cluster for studying the role of complex genomic variations in development and disease |
| Investigator(s): | Sham PC, Cheah KSE, Garcia-Barcelo MM, Ng IOL, Ngan ESW, Yang W |
| Department: | Centre for PanorOmic Sciences |
| Source(s) of Funding: | Small Equipment Grant |
| Start Date: | 04/2018 |
| List of Research Outputs |
| Ho D.W.H., Tsui Y.M., Sze M.F., Chan L.K., Cheung T.T., Cheng L., Lee E., Wu A.R., Sham P.C., Tsui S.K.W., Lee T.K.W. and Ng I.O.L., Single-Cell Transcriptome Sequencing Reveals Intra-Tumor Heterogeneity and Rare Stemness-Related Cell Subpopulation in Hepatocellular Carcinoma, 12th Annual Conference of the International Liver Cancer Association. 2018. |
| Ho D.W.H., Tsui Y.M., Sze M.F., Chan L.K., Cheung T.T., Cheng L., Lee E., Wu A.R., Sham P.C., Tsui S.K., Lee T.K. and Ng I.O.L., Single-Cell Transcriptome Sequencing Reveals Intra-Tumor Heterogeneity and Rare Stemness-Related Cell Subpopulation in Hepatocellular Carcinoma, 9th Asia-Pacific Primary Liver Cancer Expert Meeting. 2018. |
| Li M., Jiang L., Mak S.H.T., Kwan S.H., Xue C., Chen P., Leung H.C.M., Cui L., Li T. and Sham P.C., A powerful conditional gene-based association approach implicated functionally important genes for schizophrenia, Bioinformatics. 2018, bty682. |
| Porsch R.M., Mak S.H.T. and Sham P.C., KS-Burden: Assessing distributional differences of rare variants in dichotomous traits, Cold Spring Harbor Laboratory, 2018. |
| Tang S.M., Cheung Y.Y., Lam K.S.L. and Sham P.C., Faculty of Medicine research output prize (2018-2019) - Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants, LKS Faculty of Medicine, HKU. 2019. |
| Zhou X., Cheung C.L., Karasugi T., Karppinen J., Samartzis D., Hsu Y.H., Mak S.H.T., Song Y., Chiba K., Kawaguchi Y., LI Y., Chan D., Cheung K.M.C., Ikegawa S., Cheah K.S.E. and Sham P.C., Trans-ethnic polygenic analysis supports genetic overlap of lumbar disc degeneration with height, body mass index, and bone mineral density., Frontiers in Genetics. 2018. |