DEPT OF PAEDIATRICS & ADOLESCENT MED
| Researcher : CHAN TF |
| List of Research Outputs |
| Hui K.F., CHAN T.F., Yang W., Shen J.J., Lam K.P., Kwok H.I.N., Sham P.C., Tsao G.S.W., Kwong D.L.W., Lung M.L. and Chiang A.K.S., High risk Epstein‐Barr virus variants characterized by distinct polymorphisms in the EBER locus are strongly associated with nasopharyngeal carcinoma, International Journal of Cancer. 2019, 144: 3031-3042. |
| Researcher : Chan CM |
| List of Research Outputs |
| Chung B.H.Y., Lam H.M., Chan C.M., Wong W.H.S. and Lee P.P.W., Monitoring learning outcome in Paediatric specialty clerkship using E-logbook, Frontiers in Medical and Health Sciences Education 2018: Learning in Alliance: Inter-professional Health Education and Practice, Bau Institute of Medical and Health Sciences Education, HKU, 18-19 Dec 2018. |
| Chung B.H.Y., Lam H.M., Chan C.M., Wong W.L., Wong W.H.S. and Lee P.P.W., Monitoring learning outcome in paediatric specialty clerkship using e-logbook, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018. 88. |
| Lee P.P.W., Lam H.M., Chan C.M., Wong W.L., Wong W.H.S. and Chung B.H.Y., Authentic feedback in client-based learning – patient / parent satisfaction questionnaire (PSQ) as a feedback tool in clinical competence test for paediatric specialty clerkship, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018.. 2018. |
| Lee P.P.W., Lam H.M., Chan C.M., Wong W.H.S. and Chung B.H.Y., Teaching and learning physical examination in the clinical setting: Authentic assessment of multi-domain competencies for independent professional practice, Frontiers in Medical and Health Sciences Education 2018: Learning in Alliance: Inter-professional Health Education and Practice, Bau Institute of Medical and Health Sciences Education, HKU, 18-19 Dec 2018. |
| Researcher : Chan GCF |
| Project Title: | Review of local experience in the management of childhood myelodysplastic syndrome |
| Investigator(s): | Chan GCF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Other Funding Scheme |
| Start Date: | 01/2001 |
| Project Title: | Treatment protocol for childhood medulloblastoma in Hong Kong |
| Investigator(s): | Chan GCF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Other Funding Scheme |
| Start Date: | 01/2001 |
| Project Title: | Survey on the prevalence on use of alternative medical treatment in paediatric patients |
| Investigator(s): | Chan GCF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Other Funding Scheme |
| Start Date: | 09/2001 |
| Project Title: | Direct generation and functional characterization of human dendritic cells derived from bone marrow cells of leukemic origins |
| Investigator(s): | Chan GCF, Chiu CSW, Ma ESK, Huang F |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Other Funding Scheme |
| Start Date: | 07/2002 |
| Project Title: | King's/HKU Fellowship Awards 2009-10 |
| Investigator(s): | Chan GCF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | King's/HKU Fellowship Awards |
| Start Date: | 09/2009 |
| Project Title: | Molecular diagnosis for Childhood Cancers: Defining the Prognosis and Stratifying the Proper Treatments |
| Investigator(s): | Chan GCF, Tam PKH |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 01/2014 |
| Project Title: | A two-arm, randomized, double-blind, placebo-controlled trial to investigate the efficacy and safety of Everolimus (mTOR inhibitor) in pediatric patients with tuberous sclerosis and epilepsy requiring anticonvulsant treatments |
| Investigator(s): | Chan GCF, Yung AWY, Khong PL |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 09/2015 |
| Project Title: | The healing effects of mesenchymal stem cell or its soluble factors on cutaneous burn injury |
| Investigator(s): | Chan GCF, Li CB, Chan S |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| Project Title: | Automated bioreactors for expanding and monitoring mesenchymal stem cells |
| Investigator(s): | Chan GCF, Li CB, Deng R |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Matching Grant for Joint Research |
| Start Date: | 10/2016 |
| Project Title: | Investigation of Sustained Expression of Human Factor IX by Genetic Modified Human Mesenchymal Stem Cells both in vivo and in vitro |
| Investigator(s): | Chan GCF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Providence Foundation Limited |
| Start Date: | 01/2017 |
| Project Title: | Ex vivo of dendritic cell functions uner iron overload conditions in thalassaemia patients |
| Investigator(s): | Chan GCF, Ha SY, Kwong YL, Hwang YYG, Cheuk KLD, Li CB, Mok SP |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Children's Thalassaemia Foundation - General Awards |
| Start Date: | 08/2017 |
| Project Title: | Effect of bismuth compound as anti-oxidant for iron overload protection |
| Investigator(s): | Chan GCF, Sun H, Chan S |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Children's Thalassaemia Foundation - General Awards |
| Start Date: | 08/2017 |
| Project Title: | Using gene editing tool (CRISP/Cas9) to improve hemoglobin production by erythropoietic cells derived from B-thalassaemia patient-specific iPSCs |
| Investigator(s): | Chan GCF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Children's Thalassaemia Foundation - General Awards |
| Start Date: | 09/2018 |
| List of Research Outputs |
| CHEUNG T., Li W.H.C., Ho K.Y., Lam K.W.K., HO L.K., Chiu S.Y., Chan G.C.F. and Chung O.K.J., Efficacy of musical training on psychological outcomes and quality of life in Chinese pediatric brain tumor survivors, Psycho-Oncology. 2019, 28: 174-180. |
| Chan S., Wang R., Man K., Nicholls J.M., Li H., Sun H. and Chan G.C.F., A novel synthetic compound, bismuth zinc citrate, could potentially reduce cisplatin-induced toxicity without compromising the anticancer effect through enhanced expression of antioxidant protein, Translational Oncology. Elsevier Inc, 2019, 12: 788-799. |
| Deng R., Law H.Y., Shen J. and Chan G.C.F., Mini Review: Application of Human Mesenchymal Stem Cells in Gene and Stem Cells Therapy Era, In: G. Almeida-Porada; D.S. Krause, Current Stem Cell Reports. Springer International Publishing, 2018, 4: 327-337. |
| Ho K.Y., Li W.H.C., Lam K.W.K., XIA W., Chiu S.Y., Chan G.C.F. and Chung O.K.J., Relationships among fatigue, physical activity, depressive symptoms, and quality of life in Chinese children and adolescents surviving cancer, European Journal of Oncology Nursing. 2019, 38: 21-27. |
| KWOK S.Y.J., Guo M., Yang W., Ip P., LEE C.K., Lu L., Chan G.C.F., Middleton D. and van der Zanden H.G.M., Simulation of non-inherited maternal antigens acceptable HLA mismatches to increase the chance of matched cord blood units: Hong Kong’s experience, Human Immunology. 2018, 79: 539-544. |
| Kwok J.S.Y., Chu P., Ong C.Y.T., Law K., Ip P., Chan G.C.F. and Lu L., Role of Regulatory T Cells in Noninherited Maternal Antigen-Related Tolerance in Cord Blood: An in Vitro Study, Biology of Blood and Marrow Transplantation. 2019, 25: 424-435. |
| LEE C.M., Lau K.S.A., TANG H.L., Wang M., Mok T.Y., CHUNG M.F., Yan W., Shum H.C., Cheah K.S.E., Chan G.C.F., So H.K.H., Wong K.K.Y. and Tsia K.K.M., Multi‐ATOM: Ultrahigh‐throughput single‐cell quantitative phase imaging with subcellular resolution, Journal of Biophotonics. 2019, e201800479. |
| LEE C.M., Cheah K.S.E., Chan G.C.F., So H.K.H., Wong K.K.Y. and Tsia K.K.M., Quantitative phase imaging flow cytometry for ultra-large-scale single-cell biophysical phenotyping, Cytometry Part A. 2019, 95. |
| Lam K.W.K., Li W.H.C., Chung O.K.J., Ho K.Y., Chiu S.Y., Lam H.S. and Chan G.C.F., An integrated experiential training programme with coaching to promote physical activity, and reduce fatigue among children with cancer: A randomised controlled trial, Patient Education and Counseling. 2018. |
| Li W.H.C., Ho K.Y., Lam K.W.K., Lam H.S., Chiu S...Y..., Chan G.C.F., CHEUNG T., HO L.K. and Chung O.K.J., Adventure-based training to promote physical activity and reduce fatigue among childhood cancer survivors: A randomized controlled trial, International Journal of Nursing Studies. ScienceDirect, 2018, 83: 65-74. |
| Liang R., Law H.Y., Deng R., Boheler K., Chan H.S.S. and Chan G.C.F., Best Poster Presentation Award ‘Generation of Induced pluripotent stem cells from Peripheral Blood Mononuclear Cells of an X-linked Dilated Cardiomyopathy Patient. R Liang, MR Deng, AHY Law, K Boheler, SHS Chan*, GCF Chan*.[PI and supervisor], The 2nd Joint Annual Research and Scientific Meeting 2018. 2018. |
| Liang R., Deng R., Law H.Y., Chan H.S.S., Boheler K. and Chan G.C.F., Generation of Induced pluripotent stem cells from Peripheral Blood Mononuclear Cells of an X-linked Dilated Cardiomyopathy Patient., The 2nd Joint Annual Research & Scientific Meeting 2018. Hong Kong.. 2018. |
| Sou Da Rosa Duque J., Cheuk K.L.D., Chong C.Y., Ip P., Wong W.H.S., Lee P.P.W., Wong I.C.K., Chan G.C.F., Lau Y.L. and Ho M.H.K., Older age and male gender as risk factors for IgE-mediated drug allergies in Chinese children, 10th Hong Kong Allergy Convention 2018. |
| Tso W.Y.W., Liu A.P.Y., Lee T.M.C., Cheuk K.L., Shing M.K., Luk C.W., Ling S.C., Ku D.T.L., Li K., Yung A., Fung C.W., Chan S.H.S., Ho A.C.C., Ho K.W.F., Ip P. and Chan G.C.F., Neurocognitive function, performance status, and quality of life in pediatric intracranial germ cell tumor survivors, Journal of Neuro-Oncology. 2019, 141: 393-401. |
| XIA W., Li W.H.C., Lam K.W.K., Chung O.K.J., Song P.E.I.G.E., Chiu S...Y..., Chan G.C.F. and Ho K.Y., The Impact of Hematologic Cancer and Its Treatment on Physical Activity Level and Quality of Life Among Children in Mainland China, Cancer Nursing. 2018, 1. |
| Yu J.L., Khong P.L., Chiang A.K.S., Cheuk K.L.D., Ha S.Y. and Chan G.C.F., Solid liver tumours with cystic appearance: do they have the same outcome?, Hong Kong Journal of Paediatrics. 2019, 24: 70-75. |
| Researcher : Chan HSS |
| Project Title: | Comprehensive mutation analysis for childhood onset neuromuscular disorder in Chinese patients using Next Generation Sequencing panels |
| Investigator(s): | Chan HSS, Chung BHY, Lee HCH, Wong CNV |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 08/2016 |
| Completion Date: | 12/2019 |
| Project Title: | Study of transcription factors and application of CRISPR-Cas9 strategy to target intron 1 splice site mutation of a patient with X-linked dilated cardiomyopathy in restoring the dystrophin level in the cardiac muscle cells |
| Investigator(s): | Chan HSS, Chan GCF, Tan-Un KC |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research for New Staff |
| Start Date: | 10/2017 |
| Completion Date: | 10/2019 |
| Project Title: | HKU Overseas Fellowship Awards 2018-19 |
| Investigator(s): | Chan HSS |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | HKU Overseas Fellowship Awards |
| Start Date: | 09/2018 |
| List of Research Outputs |
| Chan H.S.S., Van Alfen N., Thuestad I.J., Ip J.K.J., Chan A.O.K., MAK C.C.Y., Chung B.H.Y., Aad V.E.R.R.I.P.S. and Erik-Jan K.A.M.S.T.E.E.G., A recurrent de novo DYNC1H1 tail domain mutation causes spinal muscular atrophy with lower extremity predominance, learning difficulties and mild brain abnormality, Neuromuscular Disorders. 2018. |
| Chan H.S.S., Kwong K.Y., Luk H.M., Lo I.F.M., Fung S.T.H., Tsang H.Y.M., Chung B.H.Y. and Chan A.O.K., Collagen VI related myopathy: Clinical variability of triple helical domain mutations of COL6A mutations. , International Child Neurology Congress. Mumbai, India. 14th -18 th Nov 2018. 2019. |
| Chan H.S.S., Frontier in SMA. Congress Scientific Symposium session VI , 18th Asian and Oceanian Myology Center Meeting. Mumbai 31 May -2 Jun 2019. 2019. |
| Chan H.S.S., HKU Overseas Fellowship Award 2018-2019, The University of Hong Kong. 2018. |
| Chan H.S.S., Li R.H.W., Lee V.C.Y., Tang M.H.Y. and Ng E.H.Y., Knowledge, Attitude And Ethical Consideration Of Chinese Couples Requesting Preimplantation Genetic Testing In Hong Kong., J Obstet Gynaecol Res. 2019. |
| Chan H.S.S., Progress in diagnosis and treatment in Paediatric Neuromuscular Disorder 儿童神经肌肉疾病的診治进展, 2019 Qianjiang International Forum on Neurodevelopment and Epilepsy organised by ZheJiang Society for Neuroscience and The Children’s Hospital Zhejiang University School of Medicine. 15 Jun 2019 . 2019. |
| Chan H.S.S., SMA Care with New Treatment in Hong Kong. SMA Scientific Symposium – The Evolving Perspective in SMA, SMA Scientific Symposium – The Evolving Perspective in SMA, organised by HKU Dept of Paediatrics and Adolescent Medicine and the Hong Kong Society of Neuromuscular Diseases. 13th April 2019. 2019. |
| Chan H.S.S., Spinal muscular atrophy : The challenge and the hope. Keynote lecture., The 2nd China SMA Conference 第二届中国SMA大会. Shanghai. 13-15 Nov 2018 . 2018. |
| Chiu A.Y.Y., Choi S.W.C., Hui C.K.C., Li Y.S., Lee S.L. and Chan H.S.S., 39. Reliability and validity of performance of the upper limb module for Chinese patients with Duchenne muscular dystrophy: A new useful clinical tool to monitor the disease progress and as outcome measure for therapeutic drug trial. , 18th Asian and Oceanian Myology Center Meeting 2019, Mumbai. . 2019. |
| Fung L.F., TSANG H.Y., Leung K.C., Yeung K.S., MAK C.C.Y., Fung C.W., Chan H.S.S., YU H.C. and Chung B.H.Y., A significant inflation in TGM6 genetic risk casts doubt in its causation in spinocerebellar ataxia type 35, Parkinsonism & Related Disorders. 2019. |
| Liang R., Law H.Y., Deng R., Boheler K., Chan H.S.S. and Chan G.C.F., Best Poster Presentation Award ‘Generation of Induced pluripotent stem cells from Peripheral Blood Mononuclear Cells of an X-linked Dilated Cardiomyopathy Patient. R Liang, MR Deng, AHY Law, K Boheler, SHS Chan*, GCF Chan*.[PI and supervisor], The 2nd Joint Annual Research and Scientific Meeting 2018. 2018. |
| Liang R., Deng R., Law H.Y., Chan H.S.S., Boheler K. and Chan G.C.F., Generation of Induced pluripotent stem cells from Peripheral Blood Mononuclear Cells of an X-linked Dilated Cardiomyopathy Patient., The 2nd Joint Annual Research & Scientific Meeting 2018. Hong Kong.. 2018. |
| MAK C.C.Y., Leung K.C., Mok T.K.G., Yeung K.S., Yang W., Fung C.W., Chan H.S.S., Lee S.L., Lee N.C., Pfundt R., Lau Y.L. and Chung B.H.Y., Exome sequencing for paediatric-onset diseases: impact of the extensive involvement of medical geneticists in the diagnostic odyssey, npj Genomic Medicine. 2018, 3. |
| TSANG H.Y., Kwong B.M.H., Pei L.C.S., Leung K.C., Yeung K.S., MAK C.C.Y., YU H.C., Fung L.F., Liang R., Chung B.H.Y. and Chan H.S.S., Application of whole exome sequencing in neuromuscular disorders patients in Hong Kong, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018. 17. |
| Westra D., Schouten M.I., Stunnenberg B.C., Kusters B., Saris C.G.J., Erasmus C.E., van Engelen B.G., Bulk S., Verschuuren-Bemelmans C.C., Gerkes E.H., de Geus C., van der Zwaag P.A., Chan H.S.S., Chung B.H.Y., Barge-Schaapveld D.Q.C.M., Kriek M., Sznajer Y., van Spaendonck-Zwarts K., van der Kooi A.J., Krause A., Schonewolf-Greulich B., de Die-Smu8lders C., Sallevelt S.C.E.H., Krapels I.P.C., Rasmussen M., Maystadt I., Kievit A.J.A., Witting N., Pennings M., Meijer R., Gillissen C., Kamsteeg E.J. and Voermans N.C., Panel-Based Exome Sequencing for Neuromuscular Disorders as a Diagnostic Service, Journal of Neuromuscular Diseases. 2019, 6: 241-258. |
| Zhi H., Ho H.T., Liang R., Chan H.S.S. and Ip Y.T., THE IMPACT OF PAEDIATRIC NEUROMUSCULAR DISORDERS ON PARENTS’ HEALTH-RELATED QUALITY OF LIFE AND FAMILY FUNCTIONING, 2nd Joint Annual Research and Scientific Meeting 2018. |
| 曹 玲., Chan H.S.S., 陈 万.金., 戴 毅., 葛 琳., 洪 思.琦., 黄 真., 李 淳.德., 李 海.峰., 李 西.华., 芙蓉 芙.蓉., 吕 俊.兰., 马 祎.楠., 彭 晓.音., 秦 炯., 瞿 宇.晋., 阙 呈.立., 沈 定.国., 宋 昉., 王 朝., 魏 翠.洁., 吴 丽.文., 吴 士.文., 熊 晖., 许 志.飞. and 张 成., 29. 脊髓性肌萎缩症多学科管理专家共识., 中华医学会儿科分会神经学, 2019. |
| Researcher : Chan KW |
| List of Research Outputs |
| Luk A.D.W., NI K., Wu Y., Lam K.T., Chan K.W., Lee P.P.W., Tu W., Mao H. and Lau Y.L., Type I and III Interferon Productions Are Impaired in X-Linked Agammaglobulinemia Patients Toward Poliovirus but Not Influenza Virus, Frontiers in Immunology. 2018, 9. |
| Researcher : Chan LY |
| List of Research Outputs |
| Chiu S.S.S., Kwan M.Y., Feng S., Chan L.Y., Chua H.Y., Wong J.S., Peiris J.S.M. and Cowling B.J., Early season estimate of influenza vaccination effectiveness against influenza hospitalisation in children, Hong Kong, winter influenza season 2018/19, Eurosurveillance. 2019, 24(5). |
| Feng S., Chiu S.S.S., Chan L.Y., Kwan Y.W., Wong J.S.C., Leung C.W., Lau Y.C., Sullivan S.G., Peiris J.S.M. and Cowling B.J., Effectiveness of influenza vaccination on influenza-associated hospitalisations over time among children in Hong Kong: a test-negative case-control study., Lancet Respir Med. . 2018, 6: 925-934. |
| Researcher : Chan S |
| List of Research Outputs |
| Chan S., Wang R., Man K., Nicholls J.M., Li H., Sun H. and Chan G.C.F., A novel synthetic compound, bismuth zinc citrate, could potentially reduce cisplatin-induced toxicity without compromising the anticancer effect through enhanced expression of antioxidant protein, Translational Oncology. Elsevier Inc, 2019, 12: 788-799. |
| Researcher : Chan SHS |
| Project Title: | Comprehensive mutation analysis for childhood onset neuromuscular disorder in Chinese patients using Next Generation Sequencing panels |
| Investigator(s): | Chan HSS, Chung BHY, Lee HCH, Wong CNV |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 08/2016 |
| Completion Date: | 12/2019 |
| Project Title: | Study of transcription factors and application of CRISPR-Cas9 strategy to target intron 1 splice site mutation of a patient with X-linked dilated cardiomyopathy in restoring the dystrophin level in the cardiac muscle cells |
| Investigator(s): | Chan HSS, Chan GCF, Tan-Un KC |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research for New Staff |
| Start Date: | 10/2017 |
| Completion Date: | 10/2019 |
| Project Title: | HKU Overseas Fellowship Awards 2018-19 |
| Investigator(s): | Chan HSS |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | HKU Overseas Fellowship Awards |
| Start Date: | 09/2018 |
| List of Research Outputs |
| Researcher : Chan SY |
| Project Title: | TSPYL1 and TSPYL4: Novel tumour suppressors? |
| Investigator(s): | Chan SY, Ching YP |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2017 |
| Completion Date: | 03/2019 |
| Project Title: | Nucleosome Assembly Protein TSPYL1 in epithelial-mesenchymal transition |
| Investigator(s): | Chan SY, Cheung MCH |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2019 |
| List of Research Outputs |
| Liu H., PENG L., So J., Tsang K.H., Chong C.H., Mak H.S., Chan K.M. and Chan S.Y., TSPYL2 regulates the expression of EZH2 target genes in neurons, Molecular Neurobiology . 2018. |
| Magni M., Buscemi G., Maita L., PENG L. and Chan S.Y., TSPYL2 is a novel regulator of SIRT1 and p300 activity in response to DNA damage, Cell Death and Differentiation . 2018. |
| Mio M., Sugiki T., Matsuda C., Mitsuhashi H., Kojima C., Chan S.Y., Hayashi Y.K. and Mio K., Structural instability of lamin A tail domain modulates its assembly and higher order function in Emery–Dreifuss muscular dystrophy, Biochemical and Biophysical Research Communications. 2019, 512: 22-28. |
| Researcher : Chee WYY |
| List of Research Outputs |
| Chee W.Y.Y., Wong S.C.M., Wong R.M.S., Wong K.Y. and Lau C.T., Associated anomalies and clinical outcomes in infants with omphalocele: a single-centre 10-year review, Hong Kong Journal of Paediatrics. 2018, 23(3): 220-224. |
| Researcher : Chen R |
| List of Research Outputs |
| Chen R., Lau Y.L. and Yang W., Detecting Small Inversions Using SRinversion, Methods in Molecular Biology. Humana Press, 2018, 107-114. |
| Researcher : Cheuk DKL |
| Project Title: | Renal dysfunction in patients with transfusion-dependent thalassaemia (REDEFINE study) |
| Investigator(s): | Cheuk KLD |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Children's Thalassaemia Foundation - General Awards |
| Start Date: | 10/2016 |
| List of Research Outputs |
| Researcher : Cheuk KLD |
| Project Title: | Renal dysfunction in patients with transfusion-dependent thalassaemia (REDEFINE study) |
| Investigator(s): | Cheuk KLD |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Children's Thalassaemia Foundation - General Awards |
| Start Date: | 10/2016 |
| List of Research Outputs |
| Li W.Y.V., Liu A.P.Y., So K.F., Ho K.K., Yau J.P., Cheuk K.L.D. and Cheung Y.F., 2D and 3D myocardial strain imaging fails to reveal sexual dimorphism of anthracycline-induced cardiotoxicity in long-term survivors of childhood cancers, European Heart Journal. 2018, 39. |
| Li W.Y.V., Liu A.P.Y., Wong W.H.S., Ho K.K., Yau J.P., Cheuk K.L.D. and Cheung Y.F., Left and right ventricular systolic and diastolic functional reserves are impaired in anthracycline-treated long-term survivors of childhood cancers, American Heart Association Scientific Sessions 2017. 2018, 136. |
| Li W.Y.V., Liu A.P.Y., Wong W.H.S., Ho K.K., Yau J.P., Cheuk K.L.D. and Cheung Y.F., Left and right ventricular systolic and diastolic functional reserves are impaired in anthracycline-treated long-term survivors of childhood cancers, J Am Soc Echocardiogr. 2019, 32: 277-285. |
| Li W.Y.V., Liu A.P.Y., Ho K.K., Yau J.P., Cheuk K.L.D. and Cheung Y.F., Resting and exercise arterial dysfunction in anthracycline-treated adult survivors of childhood cancers, Cardio-Oncology. 2018, 4: 9. |
| Li W.Y.V., Liu A.P.Y., So K.F., Ho K.K., Yau J.P., Cheuk K.L.D. and Cheung Y.F., Two- And Three-dimensional Myocardial Strain Imaging In The Interrogation Of Sex Differences In Cardiac Mechanics Of Long-term Survivors Of Childhood Cancers, Int J Cardiovasc Imaging. 2019, 35: 999-1007. |
| Sou Da Rosa Duque J., Cheuk K.L.D., Chong C.Y., Ip P., Wong W.H.S., Lee P.P.W., Wong I.C.K., Chan G.C.F., Lau Y.L. and Ho M.H.K., Older age and male gender as risk factors for IgE-mediated drug allergies in Chinese children, 10th Hong Kong Allergy Convention 2018. |
| TONG X., LI W.Y.V., Liu A.P.Y., So K.F., Chan Q., Ho K.K.H., Yau J.P.W., Cheuk K.L.D., Cheung Y.F. and Ng M.Y., Cardiac Magnetic Resonance T1 Mapping in Adolescent and Young Adult Survivors of Childhood Cancers, Circulation: Cardiovascular Imaging. 2019, 12. |
| Yu J.L., Khong P.L., Chiang A.K.S., Cheuk K.L.D., Ha S.Y. and Chan G.C.F., Solid liver tumours with cystic appearance: do they have the same outcome?, Hong Kong Journal of Paediatrics. 2019, 24: 70-75. |
| Researcher : Cheung PT |
| Project Title: | The Endocrine Society 83rd Annual Meeting Mutations of the CYP11B2 Gene in a Patient with Corticosterone Methyl Oxidase Type II Deficiency |
| Investigator(s): | Cheung PT |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2001 |
| Project Title: | International Perinatal Collegium 2005 Meeting New Approaches in Old Models - Identification of Novel Molecular Alterations in Neonatal Mouse Hypoxic-Ischaemic Brain Damage |
| Investigator(s): | Cheung PT |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2005 |
| Project Title: | 4th Asian Epigenomics Meeting Methyl mercury induced epigenetic dysregulation of BDNF gene in NG108 cells in vitro – a possible mechanism of environment-epigenome interactions underlying neuropsychiatric and neurodevelopmental disorders. |
| Investigator(s): | Cheung PT |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2009 |
| Project Title: | 9th Joint Meeting of Paediatric Endocrinology; Effective treatment with low dose dihydrotestosterone gel on three Chinese boys with 5-alpha-reductase II deficiency |
| Investigator(s): | Cheung PT |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2013 |
| Researcher : Cheung YF |
| Project Title: | CSX/NKX2.5 mutations in patients with pulmonary atresia and intact ventricular septum |
| Investigator(s): | Cheung YF, Chan SY |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Project Title: | Development of a multimedia tool for teaching of paediatric cardiology |
| Investigator(s): | Cheung YF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Run Run Shaw Research and Teaching Endowment Fund - Teaching Grants |
| Start Date: | 04/2004 |
| Project Title: | Circulating Transforming Growth Factor-β and Aortic Dilation in Patients with Repaired Congenital Heart Disease |
| Investigator(s): | Cheung YF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2015 |
| Project Title: | Right and Left Atrial Function in Patients with Thalassaemia Major: Interaction with Ventricular Diastolic Function and Arterial Mechanics (Project No. 2015/07) |
| Investigator(s): | Cheung YF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Children's Thalassaemia Foundation - General Awards |
| Start Date: | 11/2015 |
| Project Title: | Multi-modality evaluation of cardiac function in children late after cancer therapy: the emerging field of paediatric cardio-oncology |
| Investigator(s): | Cheung YF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Children's Cancer Foundation - General Award |
| Start Date: | 01/2016 |
| Project Title: | Novel MRI T1 mapping for estimation of T1 relaxation time of myocardium in patients with beta-thalassaemia major |
| Investigator(s): | Cheung YF, See WSQ, Chan GCF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Children's Thalassaemia Foundation - General Awards |
| Start Date: | 01/2017 |
| Project Title: | Remote Ischaemic Preconditioning in Paediatric Cancer Patients Receiving Anthracyline Therapy |
| Investigator(s): | Cheung YF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2018 |
| List of Research Outputs |
| Li W.Y.V., Liu A.P.Y., So K.F., Ho K.K., Yau J.P., Cheuk K.L.D. and Cheung Y.F., 2D and 3D myocardial strain imaging fails to reveal sexual dimorphism of anthracycline-induced cardiotoxicity in long-term survivors of childhood cancers, European Heart Journal. 2018, 39. |
| Li W.Y.V., Liu A.P.Y., Wong W.H.S., Ho K.K., Yau J.P., Cheuk K.L.D. and Cheung Y.F., Left and right ventricular systolic and diastolic functional reserves are impaired in anthracycline-treated long-term survivors of childhood cancers, American Heart Association Scientific Sessions 2017. 2018, 136. |
| Li W.Y.V., Liu A.P.Y., Wong W.H.S., Ho K.K., Yau J.P., Cheuk K.L.D. and Cheung Y.F., Left and right ventricular systolic and diastolic functional reserves are impaired in anthracycline-treated long-term survivors of childhood cancers, J Am Soc Echocardiogr. 2019, 32: 277-285. |
| Li W.Y.V., Liu A.P.Y., Ho K.K., Yau J.P., Cheuk K.L.D. and Cheung Y.F., Resting and exercise arterial dysfunction in anthracycline-treated adult survivors of childhood cancers, Cardio-Oncology. 2018, 4: 9. |
| Li W.Y.V., Liu A.P.Y., So K.F., Ho K.K., Yau J.P., Cheuk K.L.D. and Cheung Y.F., Two- And Three-dimensional Myocardial Strain Imaging In The Interrogation Of Sex Differences In Cardiac Mechanics Of Long-term Survivors Of Childhood Cancers, Int J Cardiovasc Imaging. 2019, 35: 999-1007. |
| TONG X., LI W.Y.V., Liu A.P.Y., So K.F., Chan Q., Ho K.K.H., Yau J.P.W., Cheuk K.L.D., Cheung Y.F. and Ng M.Y., Cardiac Magnetic Resonance T1 Mapping in Adolescent and Young Adult Survivors of Childhood Cancers, Circulation: Cardiovascular Imaging. 2019, 12. |
| Researcher : Chiang AKS |
| Project Title: | Genetic studies of tubercubosis |
| Investigator(s): | Chiang AKS |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Other Funding Scheme |
| Start Date: | 03/2002 |
| Project Title: | Prospective study of virologic and immunologic parameters of primary Epstein-Barr virus infection in Chinese children |
| Investigator(s): | Chiang AKS, Chan KH |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2003 |
| Project Title: | Prospective study of Epstein-Barr virus (EBV) strains in primary EBV infection |
| Investigator(s): | Chiang AKS |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Project Title: | Longitudinal study of Epstein-Barr virus specific antibody responses in childhood infectious mononucleosis |
| Investigator(s): | Chiang AKS |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2005 |
| Project Title: | Delineating pathogenic mutations in Epstein-Barr virus genomes of nasopharyngeal carcinoma using next generation sequencing technology |
| Investigator(s): | Chiang AKS, Lung ML, Sham PC, Yang W, Kwong DLW |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2015 |
| Project Title: | Mechanism of cell death by inhibition of histone deacetylation and proteasome degradation pathways in Burkitt lymphoma and lymphoblastoid cells |
| Investigator(s): | Chiang AKS, Hui KF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2017 |
| Project Title: | Reactivation of Epstein-Barr virus (EBV) lytic cycle in EBV-associated epithelial malignancies by iron chelators and evaluation of its therapeutic potential |
| Investigator(s): | Chiang AKS, Hui KF, Yang D |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2017 |
| Project Title: | Effects on induction of viral lytic cycle in Epstein-Barr virus-associated epithelial malignancies by combining histone deacetylase inhibitor and a novel organic compound |
| Investigator(s): | Chiang AKS, Hui KF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2018 |
| Project Title: | 2018 ASH meeting on lymphoma biology; Targeting Viral and Cellular Pro-survival Mechanisms by Combining Proteasome Inhibitor with Either Histone Deacetylase Inhibitor or Bcl-2 Inhibitor in Epstein-Barr virus-associated Lymphoma |
| Investigator(s): | Chiang AKS |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2018 |
| Completion Date: | 08/2018 |
| Project Title: | Targeting Epstein-Barr virus in nasopharyngeal carcinoma: from mechanistic study to novel therapeutic development |
| Investigator(s): | Chiang AKS |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 03/2019 |
| Project Title: | Longitudinal analysis of Epstein-Barr virus-specific T cells and NK cell responses in paediatric patients with infectious mononucleosis and post-transplant lymphoproliferative disorder |
| Investigator(s): | Chiang AKS, Hui KF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2019 |
| List of Research Outputs |
| Chan T.F., Hui K.F., Yang W., Shen J.J., Lam K.P., Kwok H., Sham P.C., Tsao G.S.W., Kwong D.L.W., Lung M.L. and Chiang A.K.S., Genome-wide analysis identifies high-risk Epstein-Barr virus associated with nasopharyngeal carcinoma., HKU Research Postgraduate Seminar, December 5-7, 2018.. 2018. |
| Hui K.F., CHAN T.F., Yang W., Shen J.J., Lam K.P., Kwok H.I.N., Sham P.C., Tsao G.S.W., Kwong D.L.W., Lung M.L. and Chiang A.K.S., High risk Epstein‐Barr virus variants characterized by distinct polymorphisms in the EBER locus are strongly associated with nasopharyngeal carcinoma, International Journal of Cancer. 2019, 144: 3031-3042. |
| Lin W., Yip Y.L., Jia L.J., Deng W., Zheng H., Dai W., Ko J.M.Y., Lo K.W., Chung G.T.Y., Yip K.Y., Lee S.D., Kwan J.S.H., Zhang J., Liu T.F., Chan Y.W., Kwong D.L.W., Lee V.H.F., Nicholls J.M., Busson P., Liu X.F., Chiang A.K.S., Hui K.F., Kwok H., Cheung S.T., Cheung Y.C., Chan C.K., Li B., Cheung A., Hau P.M., Zhou Y., Tsang C.M., Middeldorp J., Chen H., Lung M.L. and Tsao G.S.W., Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma, Nature Communications. 2018, 7; 9(1): 4663. |
| Liu A.P.Y., Ip J.K.J., Leung A.W.K., Luk C.W., Li C.H., Ho K.K.H., Lo C.L.R., Chan E.K.W., Chan A.C.Y., Chung H.Y. and Chiang A.K.S., Treatment outcome and pattern of failure in hepatoblastoma treated with a consensus protocol in Hong Kong, Pediatric Blood & Cancer. 2018, 66(1): e27482. |
| YIU P.T.S., Hui K.F., Choi C.K., Kao R.Y.T., MA C.W., Yang D. and Chiang A.K.S., Intracellular Iron Chelation by a Novel Compound, C7, Reactivates Epstein–Barr Virus (EBV) Lytic Cycle via the ERK-Autophagy Axis in EBV-Positive Epithelial Cancers, Cancers. 2018, 10: 505. |
| Yu J.L., Khong P.L., Chiang A.K.S., Cheuk K.L.D., Ha S.Y. and Chan G.C.F., Solid liver tumours with cystic appearance: do they have the same outcome?, Hong Kong Journal of Paediatrics. 2019, 24: 70-75. |
| Researcher : Chim S |
| List of Research Outputs |
| McDonell L.M., Leung K.C., Daoud H., Ip J.K.J., Chim S., Luk H.M., Lan C.L.L., Boycott K.M. and Chung B.H.Y., Mosaic KRAS mutation in a patient with encephalocraniocutaneous lipomatosis and renovascular hypertension , American Journal of Medical Genetics Part A. 2018. |
| Researcher : Chiu SSS |
| Project Title: | Streptococcus pneumoniae carriage in young children in Hong Kong |
| Investigator(s): | Chiu SSS, Ho PL |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health Services Research Fund - Full Grants |
| Start Date: | 10/1999 |
| Project Title: | Impact of universal vaccination with the 7-valent conjugate pneumocccal vaccine (PCV7) in Hong Kong on the incidence of pneumonia hospitalization and carriage in children |
| Investigator(s): | Chiu SSS, Ho PL |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Centre for Health Protection |
| Start Date: | 07/2010 |
| List of Research Outputs |
| Chiu S.S.S., Kwan M.Y., Feng S., Chan L.Y., Chua H.Y., Wong J.S., Peiris J.S.M. and Cowling B.J., Early season estimate of influenza vaccination effectiveness against influenza hospitalisation in children, Hong Kong, winter influenza season 2018/19, Eurosurveillance. 2019, 24(5). |
| Feng S., Chiu S.S.S., Chan L.Y., Kwan Y.W., Wong J.S.C., Leung C.W., Lau Y.C., Sullivan S.G., Peiris J.S.M. and Cowling B.J., Effectiveness of influenza vaccination on influenza-associated hospitalisations over time among children in Hong Kong: a test-negative case-control study., Lancet Respir Med. . 2018, 6: 925-934. |
| Yang L., Chan K.P., Wong C.M., Chiu S.S.S., Magalhaes R.J.S., Thach T.Q., Peiris J.S.M., Clements A.C.A. and Hu W., Comparison of influenza disease burden in older populations of Hong Kong and Brisbane: the impact of influenza and pneumococcal vaccination, BMC Infectious Diseases. 2019, 19(1): 162. |
| Yang L., Wong C.M., Chiu S.S.S., Cowling B.J. and Peiris J.S.M., Estimation of excess mortality and hospitalisation associated with the 2009 pandemic influenza, Hong Kong Medical Journal. 2018, 24: 19-22. |
| Researcher : Chiu TA |
| List of Research Outputs |
| Chiu T.A., Chung C.Y., Wong W.H.S., Lee S.L. and Chung B.H.Y., Healthcare burden of rare diseases in Hong Kong – adopting ORPHAcodes in ICD-10 based healthcare administrative datasets, Orphanet Journal of Rare Diseases. 2018, 13: 147. |
| Chung C.Y., Chiu T.A., Wong W.H.S., Lee S.L. and Chung B.H.Y., Healthcare burden of rare diseases in Hong Kong – Adopting orphacodes in ICD-10 based healthcare administrative datasets, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018.. 2018, 22. |
| Kwong K.Y., Chiu T.A., TSANG H.Y., Lun K.S., Rodenburg R.J.T., Smeitink J., Chung B.H.Y. and Fung C.W., A fatal case of COQ7-associated primary coenzyme Q10 deficiency , JIMD Reports. 2019, 47: 23-29. |
| Researcher : Choi CK |
| List of Research Outputs |
| YIU P.T.S., Hui K.F., Choi C.K., Kao R.Y.T., MA C.W., Yang D. and Chiang A.K.S., Intracellular Iron Chelation by a Novel Compound, C7, Reactivates Epstein–Barr Virus (EBV) Lytic Cycle via the ERK-Autophagy Axis in EBV-Positive Epithelial Cancers, Cancers. 2018, 10: 505. |
| Researcher : Chong CH |
| List of Research Outputs |
| Liu H., PENG L., So J., Tsang K.H., Chong C.H., Mak H.S., Chan K.M. and Chan S.Y., TSPYL2 regulates the expression of EZH2 target genes in neurons, Molecular Neurobiology . 2018. |
| Researcher : Chong CY |
| List of Research Outputs |
| Sou Da Rosa Duque J., Chong C.Y., Lau Y.L. and Ho M.H.K., Cross-reactivity pattern of a rare presentation of generalized delayed-type hypersensitivity to local anaesthetics, Asian Pacific Journal Of Allergy And Immunology. 2018. |
| Sou Da Rosa Duque J., Cheuk K.L.D., Chong C.Y., Ip P., Wong W.H.S., Lee P.P.W., Wong I.C.K., Chan G.C.F., Lau Y.L. and Ho M.H.K., Older age and male gender as risk factors for IgE-mediated drug allergies in Chinese children, 10th Hong Kong Allergy Convention 2018. |
| Yeung K.S., Lee T.L., Mok M.Y., Mak C.C.Y., Yang W., Chong C.Y., Lee P.P.W., Ho M.H.K., Choufani S., Lau W.C.S., Lau Y.L., Weksberg R. and Chung B.H.Y., Cell Lineage-specific Genome-wide DNA Methylation Analysis of Patients with Paediatric-onset Systemic Lupus Erythematosus, Epigenetics. 2019. |
| Researcher : Chow CB |
| Project Title: | Measuring the burden of fatal and nonfatal injury in Hong Kong |
| Investigator(s): | Chow CB, Ip P, McGhee S, Tsui MSH, Kam CW, Chan EWY, Wong WHS, Chiu IWS |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2014 |
| Project Title: | Measuring the practicability and effectiveness of online-based injury prevention anticipatory guidance |
| Investigator(s): | Chow CB, Ip P, Wong WHS, Tang MHY |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health Care and Promotion Scheme - Research Grant Projects |
| Start Date: | 07/2016 |
| Completion Date: | 10/2019 |
| Project Title: | Developing indicators to monitor injury trend and burden in Hong Kong |
| Investigator(s): | Chow CB, Ip P, Wong WHS |
| Department: | The University of Hong Kong |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 08/2016 |
| Researcher : Chu WY |
| List of Research Outputs |
| Leung K.C., Luk H.M., Tang H.M.V., Gao W., MAK C.C.Y., YU H.C., Wong W.L., Chu W.Y., Yang W., Wong W.H.S., Ma C.H., Leung A.Y.H., Jin D., Chan Y.K., Allanson J., Lo F.M.I. and Chung B.H.Y., Integrating Functional Analysis in the Next-Generation Sequencing Diagnostic Pipeline of RASopathies, Scientific Reports. 2018, 8: 2421. |
| Strehlow V., Heyne H.O., Vlaskamp D.R.M., Marwick K.F.M., Rudolf G., de Bellescize J., Biskup S., Brilstra E.H., Brouwer O.F., Callenbach P.M.C., Hentschel J., Hirsch E., Kind P.C., Mignot C., Platzer K., Rump P., Skehel P.A., Wyllie D.J.A., Hardingham G.E., van Ravenswaaj-Aris C.M.A., Lesca G., Lemke J.R., Arzimanoglou A., Augustijn P.B., Van Bogaert P., Bourry H., Burfeind P., Chu W.Y., Chung B.H.Y., Doummar D., Edery P., Fattai-Valevski A., Fradin M., Gerard M., de Geus C., Gunning S., Hasaerts D., Helbig I., Heibig K.L., Jamra R., Lyver M.J., Wassink-Ruifer J.S.K., Koolen D.A., Lederer D., Lunsing R.J., Mathot M., Maurey H., Manascu S., Mishel A., Mirzaa G., Mittler D., Muhie H., Malter R.S., Nava C., O'Brien M., van Piruderen-Nagler E., van Riesen A., Rougeot C., Sariaville D., Schieving J.H., Syrte S., Veenstra-Knol H.E., Verbeek N., Ville D., Vos Y.J., Vrielynck P., Wagner S., Weckhuysen S. and Willemsen M.H., GRIN2A -related disorders: genotype and functional consequence predict phenotype , Brain. 2019, 142: 80-92. |
| van der Sluijs E., Jansen S., Vergano S.A., Adachi-Fukuda M., Alanay T., Alkindy A., Baban A., Bayat A., Beck-Woddl S., Berry K., Bijsma E.K., Bok L.A., Brouwer A.F.J., vab der Burgt I., Campeau P.M., Canham N., Chrzanowska K., Chu W.Y., Chung B.H.Y., Dahan K., De Rademaeker M., Destree A., Dudding-Byth T., Earl R., Elcioglu N., Elias E.R., Fagerberg C., Gardham A., Gener B., Gerkes E.H., Grasshoff U., van Haeringen A., Heitink K.R., Herkert J.C., den Hollander N.S., Horn D., Hunt D., Kant S.G., Kato M., Kayserili H., Kersseboom R., Kilic E., Krajewska-Walasek M., Lammers K., Laulund L.W., Lederer D., Lees M., Lopez-Gonzalez V., Maas S., Mancini G.M.S., Marcelis C., Martinez F., Maystadt I., McGuire M., McKee S., Mehta S., Metcalfe K., Milunsky J., Mizuno S., Moeschler J.B., Netzer C., Ockeloen C.W., Oehl-Jaschkowitz B., Okamoto N., Olminkhof S.N.M., Orellana C., Pasquier L., Pottinger C., Riehmer V., Robertson S.P., Roifman M., Rooryck C., Ropers F.G., Rosello M., Ruivenkamp C.A.L., Sagiroglu M.S., Sallevelt S.C.E.H., Sanchis Calvo A., Simsek-Kipser P.O., Soares G., Solaeche L., Mujgan Sonmez F., Splitt M., Steenbeek D., Stegmann A.P.A., Stumpel C.T.R.M., Tanabe S., Uctepe E., Utine G.E., Veenstra-Knol H.E., Venkateswaran S., Vilain C., Vincent-Delorme C., Vulto-van Silfhout A.T., Wheeler P., Wilson G.N., Wilson L.C., Wollnik B., Kosho T., Wieczorek D., Eichler E., Pfundt R., de Vries B.B.A., Clayuton-Smith J. and Santen G.W.E., The ARID1B spectrum in 143 patients: from nonsyndromic intellectual disability to Coffin–Siris syndrome, Genetics in Medicine. 2018. |
| Researcher : Chung BHY |
| Project Title: | Copy-number variations in Chinese patients with conotruncal defects - a pilot study of 100 patients |
| Investigator(s): | Chung BHY, Liu APY |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Children's Heart Foundation - General Award |
| Start Date: | 03/2013 |
| Project Title: | Comprehensive Evaluation of Disable Infants and Children with Genetic Disorders |
| Investigator(s): | Chung BHY, Lau YL |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | The Society for the Relief of Disabled Children |
| Start Date: | 09/2015 |
| Project Title: | Using Paired-end whole genome sequencing to investigate balanced chromosomal translocation associated with congenital anomalies/neurodevelopmental disorders |
| Investigator(s): | Chung BHY |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| Completion Date: | 12/2018 |
| Project Title: | Phenotypes associated with rare diseases and genetic disorders affecting patients from diverse Asian ethnicity |
| Investigator(s): | Chung BHY |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | FDNA, Inc. - General Award |
| Start Date: | 07/2017 |
| Project Title: | Undiagnosed disease programme |
| Investigator(s): | Chung BHY |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Medix Medical Services Asia Limited |
| Start Date: | 09/2017 |
| Project Title: | A new candidate gene for human heterotaxy - does it cause ciliopathy and congenital malformation ? |
| Investigator(s): | Chung BHY |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2018 |
| Project Title: | Evaluating the Analytical Validity and Clinical Utility of Whole-Genome Sequencing for Cytogenetically Balanced Chromosomal Abnormalities in Prenatal Diagnosis |
| Investigator(s): | Chung BHY, Yang W |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health and Medical Research Fund - Mini Grant |
| Start Date: | 06/2018 |
| Completion Date: | 10/2019 |
| Project Title: | 39th Annual David W. Smith Workshop on Malformations and Morphogenesis; PATERNAL UNIPARENTAL DISOMY OF CHROMOSOME 19 IN A PAIR OF MONOCHORIONIC DIAMNIOTIC TWINS WITH DYSMORPHIC FEATURES AND DEVELOPMENTAL DELAY |
| Investigator(s): | Chung BHY |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2018 |
| Completion Date: | 08/2018 |
| Project Title: | Evaluating the diagnostic impact of rapid whole-exome sequencing for critically ill paediatric patients in Hong Kong |
| Investigator(s): | Chung BHY |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2019 |
| Project Title: | Evaluating the diagnostic impact and cost-effectiveness of rapid whole-exome sequencing for critically ill neonates and infants in Hong Kong |
| Investigator(s): | Chung BHY, Wong RMS, Wong WHS, Yeung KS |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2019 |
| List of Research Outputs |
| Chan H.S.S., Van Alfen N., Thuestad I.J., Ip J.K.J., Chan A.O.K., MAK C.C.Y., Chung B.H.Y., Aad V.E.R.R.I.P.S. and Erik-Jan K.A.M.S.T.E.E.G., A recurrent de novo DYNC1H1 tail domain mutation causes spinal muscular atrophy with lower extremity predominance, learning difficulties and mild brain abnormality, Neuromuscular Disorders. 2018. |
| Chan H.S.S., Kwong K.Y., Luk H.M., Lo I.F.M., Fung S.T.H., Tsang H.Y.M., Chung B.H.Y. and Chan A.O.K., Collagen VI related myopathy: Clinical variability of triple helical domain mutations of COL6A mutations. , International Child Neurology Congress. Mumbai, India. 14th -18 th Nov 2018. 2019. |
| Cheng S.S.W., Chan Y.K., Leung K.K.P., Au P.K.C., Tam W.K., Li S.K.M., Luk H.M., Kan S.Y.A., Chung B.H.Y., Lo F.M.I. and Tang M.H.Y., Experience of chromosomal microarray applied in prenatal and postnatal settings in Hong Kong, American Journal of Medical Genetics Part C: Seminars in Medical Genetics. 2019. |
| Chiu T.A., Chung C.Y., Wong W.H.S., Lee S.L. and Chung B.H.Y., Healthcare burden of rare diseases in Hong Kong – adopting ORPHAcodes in ICD-10 based healthcare administrative datasets, Orphanet Journal of Rare Diseases. 2018, 13: 147. |
| Chung B.H.Y., Adjudicator (poster and oral presentation), 2nd APSHG Autumn School 2018, Singapore, 31 Oct - 2 Nov 2018. 2018. |
| Chung B.H.Y., COQ10 deficiency due to biallelic COQ4 mutations - An early onset mitochondrial disorder common in Southern Chinese due to a founder mutation, 18th Manchester Dysmorphology Conference (MDC'18), Manchester, UK, 5-8 Nov 2018. |
| Chung B.H.Y., Chairman (chair of session 5: Solving diseases in clinical genetics (I), 2nd APSHG Autumn School 2018, Singapore, 31 Oct - 2 Nov 2018. 2018. |
| Chung B.H.Y., Willis B.R. and Lai P.S., Development of clinical genetics in Asia, American Journal of Medical Genetics Part C: Seminars in Medical Genetics. 2019. |
| Chung B.H.Y., Editorial Board Member, npj Genomic Medicine. 2019. |
| Chung B.H.Y., Exome sequencing identifies molecular diagnosis in children with drug-resistant epilepsy that associates with risk of sudden death, APHG 2018 Annual Meeting, San Diego, California, USA, 16-20 Oct 2018. |
| Chung B.H.Y., Faculty Teaching Medals 2018, LKS Faculty of Medicine, HKU, 14 Dec 2018. 2018. |
| Chung B.H.Y., Future of Rare Disease Research, Career Options in Rare Diseases, Rare Disease Awareness, Asian Medical Students' Association Hong Kong, 23 Nov 2018. 2018. |
| Chung B.H.Y., Genomic Medicine in Hong Kong - What have we learnt so far?, 20 THGS, 2019 Spring Symposium, Taipei, Taiwan, 24 March 2019. |
| Chung B.H.Y., Genomic Medicine in Hong Kong – what have we learnt so far?, National Children’s Hospital, Shanghai Childrern’s Medical Centre, Shanghai, PR China, 28-30 Dec 2018. 2018. |
| Chung B.H.Y., Guest Editor, American Journal of Medical Genetics (Part C) Seminar Series - June 2019 issue on Clinical Genetics in Asia. 2019. |
| Chung B.H.Y., Guest of Honour, Inauguration Ceremony of the AMSAHK Executive Committee 2018-2019, 17 Nov 2018. 2018. |
| Chung B.H.Y., Hong Kong College of Paediatricians, Member of IT Subcommittee. 2019. |
| Chung B.H.Y., Identifying the genetic causes underlying prenatally-diagnosed structural congenital anomalies (SCAs) by whole-exome sequencing (WES), Health Research Symposium, HK, 12 Jun 2019. |
| Chung B.H.Y., Interview & filming for support the campaign of CareIsNotRare project, Asian Medical Students' Association, Hong Kong, 15 Nov 2018. 2018. |
| Chung B.H.Y., Mitochondrial disease and the ethics of mitochondrial replacement therapy, Holy Spirits Seminary College Bioethics Resource Centre, HK, 27 Sept 2018. 2018. |
| Chung B.H.Y., Monitoring learning outcome in Paediatric specialty clerkship using E-logbook, Frontiers in Medical and Health Sciences Education 2018, LKS Faculty of Medicine, HKU, 19 Dec 2018. 2018. |
| Chung B.H.Y., Lam H.M., Chan C.M., Wong W.H.S. and Lee P.P.W., Monitoring learning outcome in Paediatric specialty clerkship using E-logbook, Frontiers in Medical and Health Sciences Education 2018: Learning in Alliance: Inter-professional Health Education and Practice, Bau Institute of Medical and Health Sciences Education, HKU, 18-19 Dec 2018. |
| Chung B.H.Y., Lam H.M., Chan C.M., Wong W.L., Wong W.H.S. and Lee P.P.W., Monitoring learning outcome in paediatric specialty clerkship using e-logbook, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018. 88. |
| Chung B.H.Y., NGS application in Perinatal Care, 2nd APSHG Autumn School 2018, Singapore, 31 Oct - 2 Nov 2018. 2018. |
| Chung B.H.Y., Prenatal and preimplantation genetic tests: Pitfalls and faults we have to watch for, Ovarian Club XII Meeting, HK, 15-16 Dec 2018. 2018. |
| Chung B.H.Y., Rare genetic disease by using NGS, 2018 Illumina Sequencing Symposium, Taipei, Taiwan, 12 Sept 2018. 2018. |
| Chung B.H.Y., Reviewer, Journal of GeneReviews. 2018. |
| Chung B.H.Y., Subgroup on Staff Exercise & Role Delineation, HA Strategic Service Framework for Genetic & Genomic Services (GGS SSF), Member. 2018. |
| Chung B.H.Y., Teaching and learning physical examination in the clinical setting: Authentic assessment of multi-domain competencies for independent professional practice, Frontiers in Medical and Health Sciences Education 2018, LKS Faculty of Medicine, HKU, 19 Dec 2018. 2018. |
| Chung B.H.Y., 基因編輯的最新發展, 基因科技及醫療的倫理反思, 聖神修院神哲學院生命倫理資源中心, 2018. |
| Chung C.Y., Chiu T.A., Wong W.H.S., Lee S.L. and Chung B.H.Y., Healthcare burden of rare diseases in Hong Kong – Adopting orphacodes in ICD-10 based healthcare administrative datasets, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018.. 2018, 22. |
| Cutiongco-de La Paz E.M., Chung B.H.Y., Faradz S.M.H., Thong M.K., David-Padilla C., Lai P.S., Lin S.P., Chen Y.H., Sura T. and Laurino M., Training in clinical genetics and genetic counseling in Asia, American Journal of Medical Genetics Part C: Seminars in Medical Genetics. 2019. |
| Fung L.F., TSANG H.Y., Leung K.C., Yeung K.S., MAK C.C.Y., Fung C.W., Chan H.S.S., YU H.C. and Chung B.H.Y., A significant inflation in TGM6 genetic risk casts doubt in its causation in spinocerebellar ataxia type 35, Parkinsonism & Related Disorders. 2019. |
| Fung L.F., TSANG H.Y., YU H.C. and Chung B.H.Y., TGM6 variants in Chinese population – is it disease causing?, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018. |
| Kwok S.Y., Liu A.P.Y., Chan C.Y.Y., Lun K.S., Fung L.F., MAK C.C.Y., Chung B.H.Y. and Yung T.C., Clinical and genetic profile of congenital long QT syndrome in Hong Kong: a 20-year experience in paediatrics, Hong Kong Medical Journal. 2018. |
| Kwong K.Y., Chiu T.A., TSANG H.Y., Lun K.S., Rodenburg R.J.T., Smeitink J., Chung B.H.Y. and Fung C.W., A fatal case of COQ7-associated primary coenzyme Q10 deficiency , JIMD Reports. 2019, 47: 23-29. |
| LI H., Chung B.H.Y., Wang W., Dai H.Z. and Cai J., Standard training and certification of clinical geneticist in the United States, 美國臨床遺傅專科醫師的規範化培訓與認証, Chinese Journal of Medical Genetics. 中华医学遗传学杂志, 2019, 36(1): 28. |
| Lai S.H.Y., Tung Y.L. and Chung B.H.Y., A girl with multiple epiphyseal dysplasia due to novel C.955G >T mutation in the cartilage oligomeric matrix protein, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018.. 2018, 47. |
| Lee P.P.W., Lam H.M., Chan C.M., Wong W.L., Wong W.H.S. and Chung B.H.Y., Authentic feedback in client-based learning – patient / parent satisfaction questionnaire (PSQ) as a feedback tool in clinical competence test for paediatric specialty clerkship, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018.. 2018. |
| Lee P.P.W., Lam H.M., Chan C.M., Wong W.H.S. and Chung B.H.Y., Teaching and learning physical examination in the clinical setting: Authentic assessment of multi-domain competencies for independent professional practice, Frontiers in Medical and Health Sciences Education 2018: Learning in Alliance: Inter-professional Health Education and Practice, Bau Institute of Medical and Health Sciences Education, HKU, 18-19 Dec 2018. |
| Leung K.C., Mak C.C.Y., Doherty D., Lin A., Vegas N., Cho M., Dimartino C., Weisfeld-Adams J., Lessel D., Joss S., Li C., Gonzaga-Jauregui C., Zarate Y., Troyer C., Kant S., Leung G., Barone A., Yang S., Bend E., Roadhouse C., Zahir F., Stolerman E., Bienvenu T., Orenstein N., Dobyns W., Shieh J., Waggoner D., Gripp K., Parker M., Stoler J., Lyonnet S., Cormiere-Daire V., Viskochil D., Hoffman T., Amiel J. and Chung B.H.Y., De novo C-terminal truncating mutations in MN1 cause a neurodevelopmental syndrome with distinctive facial features., European Human Genetics Conference, Gothenburg, Sweden, 15-18 June 2019. |
| Leung K.C., MAK C.C.Y., Fung L.F., Wong W.H.S., TSANG H.Y., YU H.C., Pei L.C.S., Yeung K.S., Mok T.K.G., Lee C.P., Hui P.W., Tang M.H.Y., Chan Y.K., Liu A.P.Y., Yang W., Sham P.C., Kan S.Y.A. and Chung B.H.Y., Identifying the genetic causes for prenatally diagnosed structural congenital anomalies (SCAs) by whole-exome sequencing (WES), BMC Medical Genomics. 2018, 11. |
| Leung K.C., Luk H.M., Tang H.M.V., Gao W., MAK C.C.Y., YU H.C., Wong W.L., Chu W.Y., Yang W., Wong W.H.S., Ma C.H., Leung A.Y.H., Jin D., Chan Y.K., Allanson J., Lo F.M.I. and Chung B.H.Y., Integrating Functional Analysis in the Next-Generation Sequencing Diagnostic Pipeline of RASopathies, Scientific Reports. 2018, 8: 2421. |
| MAK C.C.Y., Leung K.C., Mok T.K.G., Yeung K.S., Yang W., Fung C.W., Chan H.S.S., Lee S.L., Lee N.C., Pfundt R., Lau Y.L. and Chung B.H.Y., Exome sequencing for paediatric-onset diseases: impact of the extensive involvement of medical geneticists in the diagnostic odyssey, npj Genomic Medicine. 2018, 3. |
| McDonell L.M., Leung K.C., Daoud H., Ip J.K.J., Chim S., Luk H.M., Lan C.L.L., Boycott K.M. and Chung B.H.Y., Mosaic KRAS mutation in a patient with encephalocraniocutaneous lipomatosis and renovascular hypertension , American Journal of Medical Genetics Part A. 2018. |
| Poon W.Y.S., Tung Y.L. and Chung B.H.Y., A case of pituitary stalk interruption syndrome caused by mutation in robo1 gene presenting with early onset growth failure, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018.. 2018. |
| So P.L., Cheng Y.K.Y., Cheuk K.Y., Chiu W.K., Mak S.L., Mok S.L., Lo T.K., Yung W.K., Lo F.M.I., Chung B.H.Y., Kan S.Y.A., Lee C.P. and Tang M.H.Y., Health professionals’ involvement and information provision in genetic counseling following prenatal diagnosis of sex chromosome aneuploidy in Hong Kong, International Journal of Gynecology & Obstetrics. 2019, 144: 314-316. |
| Strehlow V., Heyne H.O., Vlaskamp D.R.M., Marwick K.F.M., Rudolf G., de Bellescize J., Biskup S., Brilstra E.H., Brouwer O.F., Callenbach P.M.C., Hentschel J., Hirsch E., Kind P.C., Mignot C., Platzer K., Rump P., Skehel P.A., Wyllie D.J.A., Hardingham G.E., van Ravenswaaj-Aris C.M.A., Lesca G., Lemke J.R., Arzimanoglou A., Augustijn P.B., Van Bogaert P., Bourry H., Burfeind P., Chu W.Y., Chung B.H.Y., Doummar D., Edery P., Fattai-Valevski A., Fradin M., Gerard M., de Geus C., Gunning S., Hasaerts D., Helbig I., Heibig K.L., Jamra R., Lyver M.J., Wassink-Ruifer J.S.K., Koolen D.A., Lederer D., Lunsing R.J., Mathot M., Maurey H., Manascu S., Mishel A., Mirzaa G., Mittler D., Muhie H., Malter R.S., Nava C., O'Brien M., van Piruderen-Nagler E., van Riesen A., Rougeot C., Sariaville D., Schieving J.H., Syrte S., Veenstra-Knol H.E., Verbeek N., Ville D., Vos Y.J., Vrielynck P., Wagner S., Weckhuysen S. and Willemsen M.H., GRIN2A -related disorders: genotype and functional consequence predict phenotype , Brain. 2019, 142: 80-92. |
| TSANG H.Y., Kwong B.M.H., Pei L.C.S., Leung K.C., Yeung K.S., MAK C.C.Y., YU H.C., Fung L.F., Liang R., Chung B.H.Y. and Chan H.S.S., Application of whole exome sequencing in neuromuscular disorders patients in Hong Kong, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018. 17. |
| TSANG H.Y., Leung K.C., Ho C.C.A., Yeung K.S., MAK C.C.Y., Pei L.C.S., YU H.C., Kan S.Y.A., Chan Y.K., Kwong K.L., Lee S.L., Yung A.W.Y., Fung C.W. and Chung B.H.Y., Exome sequencing identifies molecular diagnosis in children with drug-resistant epilepsy, Epilepsia Open. 2018. |
| Wang W., Dai H.Z., Chung B.H.Y., Li H. and Cai J., Standardization and accreditation of training programs in clinical genetics, 美國臨床遺傅學培訓基地的規範及認証標準, Chinese Journal of Medical Genetics. 中华医学遗传学杂志, 2019, 36(1): 7. |
| Westra D., Schouten M.I., Stunnenberg B.C., Kusters B., Saris C.G.J., Erasmus C.E., van Engelen B.G., Bulk S., Verschuuren-Bemelmans C.C., Gerkes E.H., de Geus C., van der Zwaag P.A., Chan H.S.S., Chung B.H.Y., Barge-Schaapveld D.Q.C.M., Kriek M., Sznajer Y., van Spaendonck-Zwarts K., van der Kooi A.J., Krause A., Schonewolf-Greulich B., de Die-Smu8lders C., Sallevelt S.C.E.H., Krapels I.P.C., Rasmussen M., Maystadt I., Kievit A.J.A., Witting N., Pennings M., Meijer R., Gillissen C., Kamsteeg E.J. and Voermans N.C., Panel-Based Exome Sequencing for Neuromuscular Disorders as a Diagnostic Service, Journal of Neuromuscular Diseases. 2019, 6: 241-258. |
| Wong T.W.K., Fung L.F. and Chung B.H.Y., Neurofibromatosis type 1 - What is diagnosis ?, Hong Kong Journal of Paediatrics (new series). 2019, 24(1): 51. |
| YU H.C., TSANG H.Y., Pei L.C.S., Chan V.C.M., Rodenburg R.J.T., Smeitink J., Lee N.N.C., Fung C.W. and Chung B.H.Y., COQ10 deficiency due to biallelic COQ4 mutations – An early onset mitochondrial disorder common in southern Chinese due to a founder mutation, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018. (Award for oral presentation - 2nd prize). 2018, 20. |
| Yeung K.S., Lee T.L., Mok M.Y., Mak C.C.Y., Yang W., Chong C.Y., Lee P.P.W., Ho M.H.K., Choufani S., Lau W.C.S., Lau Y.L., Weksberg R. and Chung B.H.Y., Cell Lineage-specific Genome-wide DNA Methylation Analysis of Patients with Paediatric-onset Systemic Lupus Erythematosus, Epigenetics. 2019. |
| Yeung K.S., Ho S.P., Lee S.L., Kan S.Y.A., Chan Y.K., Tang M.H.Y., MAK C.C.Y., Leung K.C., So P.L., Pfundt R., Marshall C.R., Scherer S.W., Choufani S., Weksberg R. and Chung B.H.Y., Paternal uniparental disomy of chromosome 19 in a pair of monochorionic diamniotic twins with dysmorphic features and developmental delay, Journal of Medical Genetics. 2018, jmedgenet-2018-105328. |
| Yu K.P.T., Luk H.M., Leung K.C., Mak C.C.Y., Cheng S.S.W., Hau E.W.L., Chan D.K.H., Lam S.T.S., Tong T.M.F., Chung B.H.Y. and Lo F.M.I., Genetic landscape of RASopathies in Chinese: Three decades' experience in Hong Kong, American Journal of Medical Genetics Part C: Seminars in Medical Genetics. 2019. |
| Yu K.P.T., Luk H.M., Chung B.H.Y. and Lo F.M.I., Myhre syndrome: a report of six Chinese patients and literature review, Clinical Dysmorphology. 2019, 1. |
| Zayts O.A., Shipman H.E., Fung L.F., Liu A.P.Y., Kwok S.Y., Tsai A.C.H., Yung T.C. and Chung B.H.Y., The different facets of “culture” in genetic counseling: A situated analysis of genetic counseling in Hong Kong, American Journal of Medical Genetics Part C: Seminars in Medical Genetics. 2019. |
| van der Sluijs E., Jansen S., Vergano S.A., Adachi-Fukuda M., Alanay T., Alkindy A., Baban A., Bayat A., Beck-Woddl S., Berry K., Bijsma E.K., Bok L.A., Brouwer A.F.J., vab der Burgt I., Campeau P.M., Canham N., Chrzanowska K., Chu W.Y., Chung B.H.Y., Dahan K., De Rademaeker M., Destree A., Dudding-Byth T., Earl R., Elcioglu N., Elias E.R., Fagerberg C., Gardham A., Gener B., Gerkes E.H., Grasshoff U., van Haeringen A., Heitink K.R., Herkert J.C., den Hollander N.S., Horn D., Hunt D., Kant S.G., Kato M., Kayserili H., Kersseboom R., Kilic E., Krajewska-Walasek M., Lammers K., Laulund L.W., Lederer D., Lees M., Lopez-Gonzalez V., Maas S., Mancini G.M.S., Marcelis C., Martinez F., Maystadt I., McGuire M., McKee S., Mehta S., Metcalfe K., Milunsky J., Mizuno S., Moeschler J.B., Netzer C., Ockeloen C.W., Oehl-Jaschkowitz B., Okamoto N., Olminkhof S.N.M., Orellana C., Pasquier L., Pottinger C., Riehmer V., Robertson S.P., Roifman M., Rooryck C., Ropers F.G., Rosello M., Ruivenkamp C.A.L., Sagiroglu M.S., Sallevelt S.C.E.H., Sanchis Calvo A., Simsek-Kipser P.O., Soares G., Solaeche L., Mujgan Sonmez F., Splitt M., Steenbeek D., Stegmann A.P.A., Stumpel C.T.R.M., Tanabe S., Uctepe E., Utine G.E., Veenstra-Knol H.E., Venkateswaran S., Vilain C., Vincent-Delorme C., Vulto-van Silfhout A.T., Wheeler P., Wilson G.N., Wilson L.C., Wollnik B., Kosho T., Wieczorek D., Eichler E., Pfundt R., de Vries B.B.A., Clayuton-Smith J. and Santen G.W.E., The ARID1B spectrum in 143 patients: from nonsyndromic intellectual disability to Coffin–Siris syndrome, Genetics in Medicine. 2018. |
| Researcher : Chung CY |
| List of Research Outputs |
| Chiu T.A., Chung C.Y., Wong W.H.S., Lee S.L. and Chung B.H.Y., Healthcare burden of rare diseases in Hong Kong – adopting ORPHAcodes in ICD-10 based healthcare administrative datasets, Orphanet Journal of Rare Diseases. 2018, 13: 147. |
| Chung C.Y., Chiu T.A., Wong W.H.S., Lee S.L. and Chung B.H.Y., Healthcare burden of rare diseases in Hong Kong – Adopting orphacodes in ICD-10 based healthcare administrative datasets, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018.. 2018, 22. |
| Researcher : Fung CW |
| Project Title: | Neurogenetic Project |
| Investigator(s): | Fung CW |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | The Society for the Relief of Disabled Children |
| Start Date: | 05/2016 |
| Project Title: | Pilot Programme for Diagnosis and Management of Mitochondrial Diseases |
| Investigator(s): | Fung CW |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | The Society for the Relief of Disabled Children |
| Start Date: | 05/2016 |
| Project Title: | Territory-wide Mitochondrial Disease Registry in Hong Kong (Phase I) and Territory-wide Inborn Errors of Metabolism Registry in Hong Kong (Phase II) |
| Investigator(s): | Fung CW |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | The Joshua Hellmann Foundation for Orphan Disease |
| Start Date: | 06/2017 |
| List of Research Outputs |
| Fung L.F., TSANG H.Y., Leung K.C., Yeung K.S., MAK C.C.Y., Fung C.W., Chan H.S.S., YU H.C. and Chung B.H.Y., A significant inflation in TGM6 genetic risk casts doubt in its causation in spinocerebellar ataxia type 35, Parkinsonism & Related Disorders. 2019. |
| Kwong K.Y., Chiu T.A., TSANG H.Y., Lun K.S., Rodenburg R.J.T., Smeitink J., Chung B.H.Y. and Fung C.W., A fatal case of COQ7-associated primary coenzyme Q10 deficiency , JIMD Reports. 2019, 47: 23-29. |
| MAK C.C.Y., Leung K.C., Mok T.K.G., Yeung K.S., Yang W., Fung C.W., Chan H.S.S., Lee S.L., Lee N.C., Pfundt R., Lau Y.L. and Chung B.H.Y., Exome sequencing for paediatric-onset diseases: impact of the extensive involvement of medical geneticists in the diagnostic odyssey, npj Genomic Medicine. 2018, 3. |
| TSANG H.Y., Leung K.C., Ho C.C.A., Yeung K.S., MAK C.C.Y., Pei L.C.S., YU H.C., Kan S.Y.A., Chan Y.K., Kwong K.L., Lee S.L., Yung A.W.Y., Fung C.W. and Chung B.H.Y., Exome sequencing identifies molecular diagnosis in children with drug-resistant epilepsy, Epilepsia Open. 2018. |
| YU H.C., TSANG H.Y., Pei L.C.S., Chan V.C.M., Rodenburg R.J.T., Smeitink J., Lee N.N.C., Fung C.W. and Chung B.H.Y., COQ10 deficiency due to biallelic COQ4 mutations – An early onset mitochondrial disorder common in southern Chinese due to a founder mutation, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018. (Award for oral presentation - 2nd prize). 2018, 20. |
| Researcher : Fung LF |
| List of Research Outputs |
| Fung L.F., TSANG H.Y., Leung K.C., Yeung K.S., MAK C.C.Y., Fung C.W., Chan H.S.S., YU H.C. and Chung B.H.Y., A significant inflation in TGM6 genetic risk casts doubt in its causation in spinocerebellar ataxia type 35, Parkinsonism & Related Disorders. 2019. |
| Fung L.F., TSANG H.Y., YU H.C. and Chung B.H.Y., TGM6 variants in Chinese population – is it disease causing?, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018. |
| Kwok S.Y., Liu A.P.Y., Chan C.Y.Y., Lun K.S., Fung L.F., MAK C.C.Y., Chung B.H.Y. and Yung T.C., Clinical and genetic profile of congenital long QT syndrome in Hong Kong: a 20-year experience in paediatrics, Hong Kong Medical Journal. 2018. |
| Leung K.C., MAK C.C.Y., Fung L.F., Wong W.H.S., TSANG H.Y., YU H.C., Pei L.C.S., Yeung K.S., Mok T.K.G., Lee C.P., Hui P.W., Tang M.H.Y., Chan Y.K., Liu A.P.Y., Yang W., Sham P.C., Kan S.Y.A. and Chung B.H.Y., Identifying the genetic causes for prenatally diagnosed structural congenital anomalies (SCAs) by whole-exome sequencing (WES), BMC Medical Genomics. 2018, 11. |
| TSANG H.Y., Kwong B.M.H., Pei L.C.S., Leung K.C., Yeung K.S., MAK C.C.Y., YU H.C., Fung L.F., Liang R., Chung B.H.Y. and Chan H.S.S., Application of whole exome sequencing in neuromuscular disorders patients in Hong Kong, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018. 17. |
| Wong T.W.K., Fung L.F. and Chung B.H.Y., Neurofibromatosis type 1 - What is diagnosis ?, Hong Kong Journal of Paediatrics (new series). 2019, 24(1): 51. |
| Zayts O.A., Shipman H.E., Fung L.F., Liu A.P.Y., Kwok S.Y., Tsai A.C.H., Yung T.C. and Chung B.H.Y., The different facets of “culture” in genetic counseling: A situated analysis of genetic counseling in Hong Kong, American Journal of Medical Genetics Part C: Seminars in Medical Genetics. 2019. |
| Researcher : Guo M |
| List of Research Outputs |
| KWOK S.Y.J., Guo M., Yang W., Ip P., LEE C.K., Lu L., Chan G.C.F., Middleton D. and van der Zanden H.G.M., Simulation of non-inherited maternal antigens acceptable HLA mismatches to increase the chance of matched cord blood units: Hong Kong’s experience, Human Immunology. 2018, 79: 539-544. |
| Researcher : Ha SY |
| List of Research Outputs |
| Yu J.L., Khong P.L., Chiang A.K.S., Cheuk K.L.D., Ha S.Y. and Chan G.C.F., Solid liver tumours with cystic appearance: do they have the same outcome?, Hong Kong Journal of Paediatrics. 2019, 24: 70-75. |
| Researcher : Ho CCA |
| List of Research Outputs |
| TSANG H.Y., Leung K.C., Ho C.C.A., Yeung K.S., MAK C.C.Y., Pei L.C.S., YU H.C., Kan S.Y.A., Chan Y.K., Kwong K.L., Lee S.L., Yung A.W.Y., Fung C.W. and Chung B.H.Y., Exome sequencing identifies molecular diagnosis in children with drug-resistant epilepsy, Epilepsia Open. 2018. |
| Researcher : Ho KW |
| Project Title: | Glasgow/HKU Early Career Mobility Funds 2018-19 |
| Investigator(s): | Ho KWF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Glasgow/HKU Early Career Mobility Fund |
| Start Date: | 06/2018 |
| List of Research Outputs |
| Researcher : Ho KWF |
| Project Title: | Glasgow/HKU Early Career Mobility Funds 2018-19 |
| Investigator(s): | Ho KWF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Glasgow/HKU Early Career Mobility Fund |
| Start Date: | 06/2018 |
| List of Research Outputs |
| Ho K.W.F., Excellent Presentation Award at 6th Guangdong-Hong Kong-Shanghai-Chongqing Paediatric Exchange Meeting, Guangdong Medical Association. 2018. |
| Tso W.Y.W., Liu A.P.Y., Lee T.M.C., Cheuk K.L., Shing M.K., Luk C.W., Ling S.C., Ku D.T.L., Li K., Yung A., Fung C.W., Chan S.H.S., Ho A.C.C., Ho K.W.F., Ip P. and Chan G.C.F., Neurocognitive function, performance status, and quality of life in pediatric intracranial germ cell tumor survivors, Journal of Neuro-Oncology. 2019, 141: 393-401. |
| Researcher : Ho MHK |
| List of Research Outputs |
| Sou Da Rosa Duque J., Chong C.Y., Lau Y.L. and Ho M.H.K., Cross-reactivity pattern of a rare presentation of generalized delayed-type hypersensitivity to local anaesthetics, Asian Pacific Journal Of Allergy And Immunology. 2018. |
| Sou Da Rosa Duque J., Cheuk K.L.D., Chong C.Y., Ip P., Wong W.H.S., Lee P.P.W., Wong I.C.K., Chan G.C.F., Lau Y.L. and Ho M.H.K., Older age and male gender as risk factors for IgE-mediated drug allergies in Chinese children, 10th Hong Kong Allergy Convention 2018. |
| Yeung K.S., Lee T.L., Mok M.Y., Mak C.C.Y., Yang W., Chong C.Y., Lee P.P.W., Ho M.H.K., Choufani S., Lau W.C.S., Lau Y.L., Weksberg R. and Chung B.H.Y., Cell Lineage-specific Genome-wide DNA Methylation Analysis of Patients with Paediatric-onset Systemic Lupus Erythematosus, Epigenetics. 2019. |
| Researcher : Ho SP |
| Project Title: | Provision of Serum Tumor Markers Tests in Osteosarcoma and other Paediatric Sarcomas |
| Investigator(s): | Ho SP, Wong TS, Gao W |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 12/2018 |
| Completion Date: | 06/2019 |
| List of Research Outputs |
| Yeung K.S., Ho S.P., Lee S.L., Kan S.Y.A., Chan Y.K., Tang M.H.Y., MAK C.C.Y., Leung K.C., So P.L., Pfundt R., Marshall C.R., Scherer S.W., Choufani S., Weksberg R. and Chung B.H.Y., Paternal uniparental disomy of chromosome 19 in a pair of monochorionic diamniotic twins with dysmorphic features and developmental delay, Journal of Medical Genetics. 2018, jmedgenet-2018-105328. |
| Researcher : Hui KF |
| List of Research Outputs |
| Chan T.F., Hui K.F., Yang W., Shen J.J., Lam K.P., Kwok H., Sham P.C., Tsao G.S.W., Kwong D.L.W., Lung M.L. and Chiang A.K.S., Genome-wide analysis identifies high-risk Epstein-Barr virus associated with nasopharyngeal carcinoma., HKU Research Postgraduate Seminar, December 5-7, 2018.. 2018. |
| Hui K.F., CHAN T.F., Yang W., Shen J.J., Lam K.P., Kwok H.I.N., Sham P.C., Tsao G.S.W., Kwong D.L.W., Lung M.L. and Chiang A.K.S., High risk Epstein‐Barr virus variants characterized by distinct polymorphisms in the EBER locus are strongly associated with nasopharyngeal carcinoma, International Journal of Cancer. 2019, 144: 3031-3042. |
| Lin W., Yip Y.L., Jia L.J., Deng W., Zheng H., Dai W., Ko J.M.Y., Lo K.W., Chung G.T.Y., Yip K.Y., Lee S.D., Kwan J.S.H., Zhang J., Liu T.F., Chan Y.W., Kwong D.L.W., Lee V.H.F., Nicholls J.M., Busson P., Liu X.F., Chiang A.K.S., Hui K.F., Kwok H., Cheung S.T., Cheung Y.C., Chan C.K., Li B., Cheung A., Hau P.M., Zhou Y., Tsang C.M., Middeldorp J., Chen H., Lung M.L. and Tsao G.S.W., Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma, Nature Communications. 2018, 7; 9(1): 4663. |
| YIU P.T.S., Hui K.F., Choi C.K., Kao R.Y.T., MA C.W., Yang D. and Chiang A.K.S., Intracellular Iron Chelation by a Novel Compound, C7, Reactivates Epstein–Barr Virus (EBV) Lytic Cycle via the ERK-Autophagy Axis in EBV-Positive Epithelial Cancers, Cancers. 2018, 10: 505. |
| Researcher : Ip P |
| Project Title: | Promoting alcohol-related attitudinal and behavioural change amongst adolescents through Internet intervention: A cluster randomised controlled trial |
| Investigator(s): | Ip P, Chow CB, Lam TH, Ho DSY, Wong WHS |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2015 |
| Project Title: | Early Childhood Intervention to Reduce Deficits of Underprivileged Children |
| Investigator(s): | Ip P, Rao N, Chan MCM |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | The Hong Kong Jockey Club Charities Trust - General Award |
| Start Date: | 08/2017 |
| Project Title: | Does methylphenidate treatment increase seizure risk in children and adolescents with Attention Deficit Hyperactivity Disorder? |
| Investigator(s): | Ip P, Fong DYT, Man KCK, Sham PC, Chan EWY, Wong ICK |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 08/2017 |
| Project Title: | Impact of early exposure to electronic devices on long term cognitive and psychosocial development of Chinese children: a 7-year cohort study |
| Investigator(s): | Ip P, Bacon-Shone J, Ho KWF, Rao N |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2019 |
| Project Title: | Commissioned Study on Vitamin D Status Infants, Young Children and Pregnant Women in Hong Kong |
| Investigator(s): | Ip P, Ho SP, Wong WHS, Tung YL |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Commissioned Study on Vitamin D Status Infants, Young Children and Pregnant Women in Hong Kong |
| Start Date: | 01/2019 |
| List of Research Outputs |
| KWOK S.Y.J., Guo M., Yang W., Ip P., LEE C.K., Lu L., Chan G.C.F., Middleton D. and van der Zanden H.G.M., Simulation of non-inherited maternal antigens acceptable HLA mismatches to increase the chance of matched cord blood units: Hong Kong’s experience, Human Immunology. 2018, 79: 539-544. |
| Kwok J.S.Y., Chu P., Ong C.Y.T., Law K., Ip P., Chan G.C.F. and Lu L., Role of Regulatory T Cells in Noninherited Maternal Antigen-Related Tolerance in Cord Blood: An in Vitro Study, Biology of Blood and Marrow Transplantation. 2019, 25: 424-435. |
| Raman S.R., Man K.C.K., Bahmanyar S., Berard A., Bilder S., Boukhris T., Bushnell G., Crystal S., Furu K., Kao Yang Y.H., Karlstad Ø., Kieler H., Kubota K., Lai E.C.C., Martikainen J.E., Maura G., Moore N., Montero D., Nakamura H., Neumann A., Pate V., Pottegård A., Pratt N.L., Roughead E.E., Macias Saint-Gerons D., Stürmer T., Su C.C., Zoega H., Sturkenbroom M.C.J.M., Chan E.W., Coghill D., Ip P. and Wong I.C.K., Trends in attention-deficit hyperactivity disorder medication use: a retrospective observational study using population-based databases, The Lancet Psychiatry. 2018. |
| Sou Da Rosa Duque J., Cheuk K.L.D., Chong C.Y., Ip P., Wong W.H.S., Lee P.P.W., Wong I.C.K., Chan G.C.F., Lau Y.L. and Ho M.H.K., Older age and male gender as risk factors for IgE-mediated drug allergies in Chinese children, 10th Hong Kong Allergy Convention 2018. |
| Sun J., Kang R., Ip P. and Rao N., Cognitive and emotional self-regulation predict early achievement in Chinese preschoolers, Paper presented at the biennial meeting of the Society for Research in Child Development Conference. Baltimore, USA, 2019. |
| Tang Y.M.J., Luo H., Wong G.H.Y., Lau M.Y., Joe G.M., Tse M.A., Ip P., Wong I.C.K. and Lum T.Y.S., Bone mineral density from early to middle adulthood in persons with Down syndrome, Journal of Intellectual Disability Research. 2019. |
| Tso W.Y.W., Chan M.C.M., Ho F.K., Rao N., Li A.M., Chan K.L., Tiwari A.F.Y., Wong I.C.K., Wing Y.K., Van Voorhees B., Li S.L., Goh W.H.S. and Ip P., Early sleep deprivation and attention-deficit/hyperactivity disorder, Pediatric Research. 2019, 85: 449-455. |
| Tso W.Y.W., Liu A.P.Y., Lee T.M.C., Cheuk K.L., Shing M.K., Luk C.W., Ling S.C., Ku D.T.L., Li K., Yung A., Fung C.W., Chan S.H.S., Ho A.C.C., Ho K.W.F., Ip P. and Chan G.C.F., Neurocognitive function, performance status, and quality of life in pediatric intracranial germ cell tumor survivors, Journal of Neuro-Oncology. 2019, 141: 393-401. |
| WONG R.S.M., Yu Y.T.E., Wong C.K.H., TUNG T.S., Wong W.H.S., Ip P. and Lam C.L.K., Associations between physical activity and health-related quality of life, behavior and telomere length among Chinese children from low-income families in Hong Kong, International Conference and Active Living and Health. 2018. |
| WONG R.S.M., Wong W.L.T., Yu Y.T.E., CHOI S.Y.C., Or K.L., Liu S.N.K., Wong C.K.H., Ip P. and Lam C.L.K., Pilot study on the efficacy of a mobile app on parent-child partner exercise to enhance health-related quality of life and behavior of children in Hong Kong Chinese families, International Conference and Active Living and Health. 2018. |
| Researcher : Kwan YW |
| List of Research Outputs |
| Feng S., Chiu S.S.S., Chan L.Y., Kwan Y.W., Wong J.S.C., Leung C.W., Lau Y.C., Sullivan S.G., Peiris J.S.M. and Cowling B.J., Effectiveness of influenza vaccination on influenza-associated hospitalisations over time among children in Hong Kong: a test-negative case-control study., Lancet Respir Med. . 2018, 6: 925-934. |
| Researcher : Kwok H |
| List of Research Outputs |
| Chan T.F., Hui K.F., Yang W., Shen J.J., Lam K.P., Kwok H., Sham P.C., Tsao G.S.W., Kwong D.L.W., Lung M.L. and Chiang A.K.S., Genome-wide analysis identifies high-risk Epstein-Barr virus associated with nasopharyngeal carcinoma., HKU Research Postgraduate Seminar, December 5-7, 2018.. 2018. |
| Researcher : Kwok SY |
| List of Research Outputs |
| Baruteau A.E., Kyndt F., Behr E.R., Vink A.S., Lachaud M., Joong A., Schott J.J., Horie M., Denjoy I., Crotti L., Shimizu W., Bos J.M., SStephenson E.A., Wong L., Abrams D.J., Davis A.M., Winbo A., Dubin A.M., Sanatani S., Liberman L., Kaski J.P., Rudic B., Kwok S.Y., Rieubland C., Tfelt-Hansen J., Van Hare G.F., Guyomarc'h-Delasalle B., Blom N.A., Wijeyeratne Y.D., Gourraud J.D., Le Marec H., Ozawa J., Fressart V., Lupoglazoff J.M., Dagradi F., Spazzolini C., Aiba T., Tester D.J., Zahavich L.A., Beausejour-Ladouceur V., Jadhav M., Skinner J.R., Franciosi S., Krahn A.D., Abdelsayed M., Ruben P.C., Yung T.C., Ackerman M.J., Wilde A.A., Schwartz P.J. and Probst V., SCN5A mutations in 442 neonates and children: genotype–phenotype correlation and identification of higher-risk subgroups, European Heart Journal. 2018, 39: 2879-2887. |
| Kwok S.Y., Liu A.P.Y., Chan C.Y.Y., Lun K.S., Fung L.F., MAK C.C.Y., Chung B.H.Y. and Yung T.C., Clinical and genetic profile of congenital long QT syndrome in Hong Kong: a 20-year experience in paediatrics, Hong Kong Medical Journal. 2018. |
| Kwok S.Y. and Tse H.F., Hybrid cardiac resynchronization with leadless pacemaker and transvenous coronary sinus lead, Europace. 2018, 20(9): 1505. |
| Zayts O.A., Shipman H.E., Fung L.F., Liu A.P.Y., Kwok S.Y., Tsai A.C.H., Yung T.C. and Chung B.H.Y., The different facets of “culture” in genetic counseling: A situated analysis of genetic counseling in Hong Kong, American Journal of Medical Genetics Part C: Seminars in Medical Genetics. 2019. |
| Researcher : Kwong KY |
| List of Research Outputs |
| Chan H.S.S., Kwong K.Y., Luk H.M., Lo I.F.M., Fung S.T.H., Tsang H.Y.M., Chung B.H.Y. and Chan A.O.K., Collagen VI related myopathy: Clinical variability of triple helical domain mutations of COL6A mutations. , International Child Neurology Congress. Mumbai, India. 14th -18 th Nov 2018. 2019. |
| Kwong K.Y., Chiu T.A., TSANG H.Y., Lun K.S., Rodenburg R.J.T., Smeitink J., Chung B.H.Y. and Fung C.W., A fatal case of COQ7-associated primary coenzyme Q10 deficiency , JIMD Reports. 2019, 47: 23-29. |
| Researcher : LI WYV |
| List of Research Outputs |
| LI W.Y.V., Cardiac Magnetic Resonance T1 Mapping in Adolescent and Young Adult Survivors of Childhood Cancers, Circ Cardiovasc Imaging. 2019, 12: e008453. |
| LI W.Y.V., Two- and three-dimensional myocardial strain imaging in the interrogation of sex differences in cardiac mechanics of long-term survivors of childhood cancers, Int J Cardiovasc Imaging. 2019, 35: 999-1007. |
| Li W.Y.V., Liu A.P.Y., So K.F., Ho K.K., Yau J.P., Cheuk K.L.D. and Cheung Y.F., 2D and 3D myocardial strain imaging fails to reveal sexual dimorphism of anthracycline-induced cardiotoxicity in long-term survivors of childhood cancers, European Heart Journal. 2018, 39. |
| Li W.Y.V., Liu A.P.Y., Wong W.H.S., Ho K.K., Yau J.P., Cheuk K.L.D. and Cheung Y.F., Left and right ventricular systolic and diastolic functional reserves are impaired in anthracycline-treated long-term survivors of childhood cancers, American Heart Association Scientific Sessions 2017. 2018, 136. |
| Li W.Y.V., Liu A.P.Y., Wong W.H.S., Ho K.K., Yau J.P., Cheuk K.L.D. and Cheung Y.F., Left and right ventricular systolic and diastolic functional reserves are impaired in anthracycline-treated long-term survivors of childhood cancers, J Am Soc Echocardiogr. 2019, 32: 277-285. |
| Li W.Y.V., Liu A.P.Y., Ho K.K., Yau J.P., Cheuk K.L.D. and Cheung Y.F., Resting and exercise arterial dysfunction in anthracycline-treated adult survivors of childhood cancers, Cardio-Oncology. 2018, 4: 9. |
| Li W.Y.V., Liu A.P.Y., So K.F., Ho K.K., Yau J.P., Cheuk K.L.D. and Cheung Y.F., Two- And Three-dimensional Myocardial Strain Imaging In The Interrogation Of Sex Differences In Cardiac Mechanics Of Long-term Survivors Of Childhood Cancers, Int J Cardiovasc Imaging. 2019, 35: 999-1007. |
| TONG X., LI W.Y.V., Liu A.P.Y., So K.F., Chan Q., Ho K.K.H., Yau J.P.W., Cheuk K.L.D., Cheung Y.F. and Ng M.Y., Cardiac Magnetic Resonance T1 Mapping in Adolescent and Young Adult Survivors of Childhood Cancers, Circulation: Cardiovascular Imaging. 2019, 12. |
| Researcher : LIANG R |
| List of Research Outputs |
| Liang R., Law H.Y., Deng R., Boheler K., Chan H.S.S. and Chan G.C.F., Best Poster Presentation Award ‘Generation of Induced pluripotent stem cells from Peripheral Blood Mononuclear Cells of an X-linked Dilated Cardiomyopathy Patient. R Liang, MR Deng, AHY Law, K Boheler, SHS Chan*, GCF Chan*.[PI and supervisor], The 2nd Joint Annual Research and Scientific Meeting 2018. 2018. |
| Liang R., Deng R., Law H.Y., Chan H.S.S., Boheler K. and Chan G.C.F., Generation of Induced pluripotent stem cells from Peripheral Blood Mononuclear Cells of an X-linked Dilated Cardiomyopathy Patient., The 2nd Joint Annual Research & Scientific Meeting 2018. Hong Kong.. 2018. |
| TSANG H.Y., Kwong B.M.H., Pei L.C.S., Leung K.C., Yeung K.S., MAK C.C.Y., YU H.C., Fung L.F., Liang R., Chung B.H.Y. and Chan H.S.S., Application of whole exome sequencing in neuromuscular disorders patients in Hong Kong, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018. 17. |
| YANG X., LIANG R., Liu C.X., Liu A.J., Cheung M.P.L., Liu X.L., Man O.Y., Guan X., Lung H.L. and Cheung M.C.H., SOX9 is a dose-dependent metastatic fate determinant in melanoma, Journal of Experimental & Clinical Cancer Research. 2019, 38. |
| Zhi H., Ho H.T., Liang R., Chan H.S.S. and Ip Y.T., THE IMPACT OF PAEDIATRIC NEUROMUSCULAR DISORDERS ON PARENTS’ HEALTH-RELATED QUALITY OF LIFE AND FAMILY FUNCTIONING, 2nd Joint Annual Research and Scientific Meeting 2018. |
| Researcher : Lam HM |
| List of Research Outputs |
| Chung B.H.Y., Lam H.M., Chan C.M., Wong W.H.S. and Lee P.P.W., Monitoring learning outcome in Paediatric specialty clerkship using E-logbook, Frontiers in Medical and Health Sciences Education 2018: Learning in Alliance: Inter-professional Health Education and Practice, Bau Institute of Medical and Health Sciences Education, HKU, 18-19 Dec 2018. |
| Chung B.H.Y., Lam H.M., Chan C.M., Wong W.L., Wong W.H.S. and Lee P.P.W., Monitoring learning outcome in paediatric specialty clerkship using e-logbook, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018. 88. |
| Lee P.P.W., Lam H.M., Chan C.M., Wong W.L., Wong W.H.S. and Chung B.H.Y., Authentic feedback in client-based learning – patient / parent satisfaction questionnaire (PSQ) as a feedback tool in clinical competence test for paediatric specialty clerkship, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018.. 2018. |
| Lee P.P.W., Lam H.M., Chan C.M., Wong W.H.S. and Chung B.H.Y., Teaching and learning physical examination in the clinical setting: Authentic assessment of multi-domain competencies for independent professional practice, Frontiers in Medical and Health Sciences Education 2018: Learning in Alliance: Inter-professional Health Education and Practice, Bau Institute of Medical and Health Sciences Education, HKU, 18-19 Dec 2018. |
| Researcher : Lam KP |
| List of Research Outputs |
| Chan T.F., Hui K.F., Yang W., Shen J.J., Lam K.P., Kwok H., Sham P.C., Tsao G.S.W., Kwong D.L.W., Lung M.L. and Chiang A.K.S., Genome-wide analysis identifies high-risk Epstein-Barr virus associated with nasopharyngeal carcinoma., HKU Research Postgraduate Seminar, December 5-7, 2018.. 2018. |
| Hui K.F., CHAN T.F., Yang W., Shen J.J., Lam K.P., Kwok H.I.N., Sham P.C., Tsao G.S.W., Kwong D.L.W., Lung M.L. and Chiang A.K.S., High risk Epstein‐Barr virus variants characterized by distinct polymorphisms in the EBER locus are strongly associated with nasopharyngeal carcinoma, International Journal of Cancer. 2019, 144: 3031-3042. |
| Researcher : Lam KT |
| List of Research Outputs |
| Lam K.T., Xiang Z., Liu Y., WANG X. and Tu W., Human Vγ9Vδ2-T cells exhibit potent antiviral activity against EV71 infection, Immunology 2019. |
| Luk A.D.W., NI K., Wu Y., Lam K.T., Chan K.W., Lee P.P.W., Tu W., Mao H. and Lau Y.L., Type I and III Interferon Productions Are Impaired in X-Linked Agammaglobulinemia Patients Toward Poliovirus but Not Influenza Virus, Frontiers in Immunology. 2018, 9. |
| Researcher : Lau ASY |
| Project Title: | Cytokines, Signaling & Diseases 2003 The Role of Protein Kinase PKR in the Induction of Cytokine Expression by Bacillus Calmette Guerin Through NF-kappaB |
| Investigator(s): | Lau ASY |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2003 |
| Project Title: | Cytokine Dysregulation and Virus-Induced Cell Death in Avian Influenza Virus Infections |
| Investigator(s): | Lau ASY, Peiris JSM |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2005 |
| Project Title: | Factors affecting mycobacteria evasion of immunity: effects of HIV on cellular signaling and kinases |
| Investigator(s): | Lau ASY |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 09/2009 |
| Researcher : Lau YL |
| Project Title: | A community-based educational program on thalassaemias to enhance awareness with the aim to reduce burden of thalassaemia related health problems in Hong Kong |
| Investigator(s): | Lau YL, Ha SY |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health Promotion Projects |
| Start Date: | 09/1997 |
| Project Title: | Comparison of process upgrade varicella vaccine (Puvv) with VARILRIX-TM |
| Investigator(s): | Lau YL |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Other Funding Scheme |
| Start Date: | 07/1999 |
| Project Title: | p21 gene polymorphism with systemic lupus erythematosus and rheumatoid arthritis |
| Investigator(s): | Lau YL, Lau WCS |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2005 |
| Project Title: | Association of cytokine and chemokine genes polymorphism with susceptibility to SARS and severity of SARS |
| Investigator(s): | Lau YL, Peiris JSM |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 09/2005 |
| Project Title: | Study on the Effectiveness and the Utilization of School-located Influenza Vaccination (SLV-1) Program in Hong Kong |
| Investigator(s): | Lau YL |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Commissioned Project: Health and Medical Research Fund |
| Start Date: | 08/2018 |
| List of Research Outputs |
| Chen R., Lau Y.L. and Yang W., Detecting Small Inversions Using SRinversion, Methods in Molecular Biology. Humana Press, 2018, 107-114. |
| Luk A.D.W., NI K., Wu Y., Lam K.T., Chan K.W., Lee P.P.W., Tu W., Mao H. and Lau Y.L., Type I and III Interferon Productions Are Impaired in X-Linked Agammaglobulinemia Patients Toward Poliovirus but Not Influenza Virus, Frontiers in Immunology. 2018, 9. |
| MAK C.C.Y., Leung K.C., Mok T.K.G., Yeung K.S., Yang W., Fung C.W., Chan H.S.S., Lee S.L., Lee N.C., Pfundt R., Lau Y.L. and Chung B.H.Y., Exome sequencing for paediatric-onset diseases: impact of the extensive involvement of medical geneticists in the diagnostic odyssey, npj Genomic Medicine. 2018, 3. |
| Sou Da Rosa Duque J., Chong C.Y., Lau Y.L. and Ho M.H.K., Cross-reactivity pattern of a rare presentation of generalized delayed-type hypersensitivity to local anaesthetics, Asian Pacific Journal Of Allergy And Immunology. 2018. |
| Sou Da Rosa Duque J., Cheuk K.L.D., Chong C.Y., Ip P., Wong W.H.S., Lee P.P.W., Wong I.C.K., Chan G.C.F., Lau Y.L. and Ho M.H.K., Older age and male gender as risk factors for IgE-mediated drug allergies in Chinese children, 10th Hong Kong Allergy Convention 2018. |
| Wang Y., Zhang Y., Zhu Z., Wang T., Morris D.L., Shen J.J., Zhang H., Pan H.F., Yang J., Yang S., Ye D.Q., Vyse T.J., Cui Y., Zhang X., Sheng Y., Lau Y.L. and Yang W., Identification of ST3AGL4 , MFHAS1, CSNK2A2 and CD226 as loci associated with systemic lupus erythematosus (SLE) and evaluation of SLE genetics in drug repositioning , Annals of the Rheumatic Diseases. 2018, 77: 1078-1084. |
| Wang Y., Lau Y.L. and Yang W., Genetic studies on systemic lupus erythematosus in East Asia point to population differences in disease susceptibility, American Journal of Medical Genetics Part C: Seminars in Medical Genetics. 2019. |
| Yeung K.S., Lee T.L., Mok M.Y., Mak C.C.Y., Yang W., Chong C.Y., Lee P.P.W., Ho M.H.K., Choufani S., Lau W.C.S., Lau Y.L., Weksberg R. and Chung B.H.Y., Cell Lineage-specific Genome-wide DNA Methylation Analysis of Patients with Paediatric-onset Systemic Lupus Erythematosus, Epigenetics. 2019. |
| ZHANG H., ZHANG Y., Wang Y., Morris D., Hirankarn N., Sheng Y., Shen J.J., Pan H.F., Yang J., Yang S., Cui Y., Ye D.Q., Vyse T.J., Zhang X., Lau Y.L. and Yang W., Meta-analysis of GWAS on both Chinese and European populations identifies GPR173 as a novel X chromosome susceptibility gene for SLE, Arthritis Research & Therapy. 2018, 20. |
| Researcher : Law HY |
| List of Research Outputs |
| Deng R., Law H.Y., Shen J. and Chan G.C.F., Mini Review: Application of Human Mesenchymal Stem Cells in Gene and Stem Cells Therapy Era, In: G. Almeida-Porada; D.S. Krause, Current Stem Cell Reports. Springer International Publishing, 2018, 4: 327-337. |
| Liang R., Law H.Y., Deng R., Boheler K., Chan H.S.S. and Chan G.C.F., Best Poster Presentation Award ‘Generation of Induced pluripotent stem cells from Peripheral Blood Mononuclear Cells of an X-linked Dilated Cardiomyopathy Patient. R Liang, MR Deng, AHY Law, K Boheler, SHS Chan*, GCF Chan*.[PI and supervisor], The 2nd Joint Annual Research and Scientific Meeting 2018. 2018. |
| Liang R., Deng R., Law H.Y., Chan H.S.S., Boheler K. and Chan G.C.F., Generation of Induced pluripotent stem cells from Peripheral Blood Mononuclear Cells of an X-linked Dilated Cardiomyopathy Patient., The 2nd Joint Annual Research & Scientific Meeting 2018. Hong Kong.. 2018. |
| Researcher : Lee PPW |
| Project Title: | TSG-6 secreted by human mesenchymal stromal cells downregulate type I interferon response in plasmacytoid dendritic cells and alleviates autoimmune nephritis in a murine model of systemic lupus erythematosus |
| Investigator(s): | Lee PPW, Chan GCF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research for Resubmission of GRF/ECS Proposals |
| Start Date: | 07/2018 |
| Completion Date: | 11/2018 |
| Project Title: | 18th Biennial Meeting of European Society for Immunodeficiencies ; TH1 AND TH17 HOST IMMUNITY AGAINST TALAROMYCES MARNEFFEI - INSIGHTS FROM MONOGENIC IMMUNODEFICIENCY SYNDROMES |
| Investigator(s): | Lee PPW |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2018 |
| Completion Date: | 10/2018 |
| List of Research Outputs |
| Chung B.H.Y., Lam H.M., Chan C.M., Wong W.H.S. and Lee P.P.W., Monitoring learning outcome in Paediatric specialty clerkship using E-logbook, Frontiers in Medical and Health Sciences Education 2018: Learning in Alliance: Inter-professional Health Education and Practice, Bau Institute of Medical and Health Sciences Education, HKU, 18-19 Dec 2018. |
| Chung B.H.Y., Lam H.M., Chan C.M., Wong W.L., Wong W.H.S. and Lee P.P.W., Monitoring learning outcome in paediatric specialty clerkship using e-logbook, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018. 88. |
| Lee P.P.W., Lam H.M., Chan C.M., Wong W.L., Wong W.H.S. and Chung B.H.Y., Authentic feedback in client-based learning – patient / parent satisfaction questionnaire (PSQ) as a feedback tool in clinical competence test for paediatric specialty clerkship, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018.. 2018. |
| Lee P.P.W., Lam H.M., Chan C.M., Wong W.H.S. and Chung B.H.Y., Teaching and learning physical examination in the clinical setting: Authentic assessment of multi-domain competencies for independent professional practice, Frontiers in Medical and Health Sciences Education 2018: Learning in Alliance: Inter-professional Health Education and Practice, Bau Institute of Medical and Health Sciences Education, HKU, 18-19 Dec 2018. |
| Li P.H., Lee P.P.W., Fung S.L., Lau W.C.S. and Lu Y.L., Chronic mucocutaneous candidiasis—more than just skin deep, Hong Kong Medical Journal. 2018, 24(4): 423-425. |
| Luk A.D.W., NI K., Wu Y., Lam K.T., Chan K.W., Lee P.P.W., Tu W., Mao H. and Lau Y.L., Type I and III Interferon Productions Are Impaired in X-Linked Agammaglobulinemia Patients Toward Poliovirus but Not Influenza Virus, Frontiers in Immunology. 2018, 9. |
| Sou Da Rosa Duque J., Cheuk K.L.D., Chong C.Y., Ip P., Wong W.H.S., Lee P.P.W., Wong I.C.K., Chan G.C.F., Lau Y.L. and Ho M.H.K., Older age and male gender as risk factors for IgE-mediated drug allergies in Chinese children, 10th Hong Kong Allergy Convention 2018. |
| Yeung K.S., Lee T.L., Mok M.Y., Mak C.C.Y., Yang W., Chong C.Y., Lee P.P.W., Ho M.H.K., Choufani S., Lau W.C.S., Lau Y.L., Weksberg R. and Chung B.H.Y., Cell Lineage-specific Genome-wide DNA Methylation Analysis of Patients with Paediatric-onset Systemic Lupus Erythematosus, Epigenetics. 2019. |
| Researcher : Lee SL |
| Project Title: | Where for Rare |
| Investigator(s): | Lee SL, Chung BHY, Chau SKC, Cheung YF, Tao QV, Tso WYW, Yung AWY, Wong RMS, Lee DCW, Wong WHS |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | The Society for the Relief of Disabled Children |
| Start Date: | 01/2017 |
| List of Research Outputs |
| Chiu T.A., Chung C.Y., Wong W.H.S., Lee S.L. and Chung B.H.Y., Healthcare burden of rare diseases in Hong Kong – adopting ORPHAcodes in ICD-10 based healthcare administrative datasets, Orphanet Journal of Rare Diseases. 2018, 13: 147. |
| Chung C.Y., Chiu T.A., Wong W.H.S., Lee S.L. and Chung B.H.Y., Healthcare burden of rare diseases in Hong Kong – Adopting orphacodes in ICD-10 based healthcare administrative datasets, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018.. 2018, 22. |
| Hon K.L., Bao Y.M., Chan K.C., Chau K.W., Chen R.S., Cheok K.T., Chiu W.K., Li D., He C.H., Leong K.M., Kung J.S., Lam P., Lam S.Y., Lee Q.U., Lee S.L., Leung T.F., Leung T.N.H., Shi L., Siu K.K., Tan W.P., Wang M.H., Wong T.W., Wu B.J., Yip Y.F., Zheng Y.J. and Ng D.K., Determinants for asthma control, quality of life and use of complementary and alternative medicine in asthmatic pediatric patients in four cities, World Journal of Pediatrics. 2018. |
| Hui L.L., Kwok M.K., Nelson E.A.S., Lee S.L., Leung G.M. and Schooling C.M., Breastfeeding in infancy and lipid profile in adolescence, Pediatrics. 2019, 143: e20183075. |
| Hui L.L., Lee S.L., Kwok M.K., Yu C.W. and Schooling C.M., Formula-feeding and the risk of type-2 diabetes mellitus among Hong Kong adolescents, Hong Kong Medical Journal. 2018, 2018;24(Suppl 4): S20-3. |
| Hui L.L., Li A.M., Nelson E.A.S., Leung G.M., Lee S.L. and Schooling C.M., In utero exposure to gestational diabetes and adiposity: does breastfeeding make a difference?, International Journal of Obesity. 2018, 42: 1317-1325. |
| MAK C.C.Y., Leung K.C., Mok T.K.G., Yeung K.S., Yang W., Fung C.W., Chan H.S.S., Lee S.L., Lee N.C., Pfundt R., Lau Y.L. and Chung B.H.Y., Exome sequencing for paediatric-onset diseases: impact of the extensive involvement of medical geneticists in the diagnostic odyssey, npj Genomic Medicine. 2018, 3. |
| TSANG H.Y., Leung K.C., Ho C.C.A., Yeung K.S., MAK C.C.Y., Pei L.C.S., YU H.C., Kan S.Y.A., Chan Y.K., Kwong K.L., Lee S.L., Yung A.W.Y., Fung C.W. and Chung B.H.Y., Exome sequencing identifies molecular diagnosis in children with drug-resistant epilepsy, Epilepsia Open. 2018. |
| Yeung K.S., Ho S.P., Lee S.L., Kan S.Y.A., Chan Y.K., Tang M.H.Y., MAK C.C.Y., Leung K.C., So P.L., Pfundt R., Marshall C.R., Scherer S.W., Choufani S., Weksberg R. and Chung B.H.Y., Paternal uniparental disomy of chromosome 19 in a pair of monochorionic diamniotic twins with dysmorphic features and developmental delay, Journal of Medical Genetics. 2018, jmedgenet-2018-105328. |
| Researcher : Lee TL |
| List of Research Outputs |
| Yeung K.S., Lee T.L., Mok M.Y., Mak C.C.Y., Yang W., Chong C.Y., Lee P.P.W., Ho M.H.K., Choufani S., Lau W.C.S., Lau Y.L., Weksberg R. and Chung B.H.Y., Cell Lineage-specific Genome-wide DNA Methylation Analysis of Patients with Paediatric-onset Systemic Lupus Erythematosus, Epigenetics. 2019. |
| Researcher : Leung KC |
| List of Research Outputs |
| Fung L.F., TSANG H.Y., Leung K.C., Yeung K.S., MAK C.C.Y., Fung C.W., Chan H.S.S., YU H.C. and Chung B.H.Y., A significant inflation in TGM6 genetic risk casts doubt in its causation in spinocerebellar ataxia type 35, Parkinsonism & Related Disorders. 2019. |
| Leung K.C., Mak C.C.Y., Doherty D., Lin A., Vegas N., Cho M., Dimartino C., Weisfeld-Adams J., Lessel D., Joss S., Li C., Gonzaga-Jauregui C., Zarate Y., Troyer C., Kant S., Leung G., Barone A., Yang S., Bend E., Roadhouse C., Zahir F., Stolerman E., Bienvenu T., Orenstein N., Dobyns W., Shieh J., Waggoner D., Gripp K., Parker M., Stoler J., Lyonnet S., Cormiere-Daire V., Viskochil D., Hoffman T., Amiel J. and Chung B.H.Y., De novo C-terminal truncating mutations in MN1 cause a neurodevelopmental syndrome with distinctive facial features., European Human Genetics Conference, Gothenburg, Sweden, 15-18 June 2019. |
| Leung K.C., MAK C.C.Y., Fung L.F., Wong W.H.S., TSANG H.Y., YU H.C., Pei L.C.S., Yeung K.S., Mok T.K.G., Lee C.P., Hui P.W., Tang M.H.Y., Chan Y.K., Liu A.P.Y., Yang W., Sham P.C., Kan S.Y.A. and Chung B.H.Y., Identifying the genetic causes for prenatally diagnosed structural congenital anomalies (SCAs) by whole-exome sequencing (WES), BMC Medical Genomics. 2018, 11. |
| Leung K.C., Luk H.M., Tang H.M.V., Gao W., MAK C.C.Y., YU H.C., Wong W.L., Chu W.Y., Yang W., Wong W.H.S., Ma C.H., Leung A.Y.H., Jin D., Chan Y.K., Allanson J., Lo F.M.I. and Chung B.H.Y., Integrating Functional Analysis in the Next-Generation Sequencing Diagnostic Pipeline of RASopathies, Scientific Reports. 2018, 8: 2421. |
| MAK C.C.Y., Leung K.C., Mok T.K.G., Yeung K.S., Yang W., Fung C.W., Chan H.S.S., Lee S.L., Lee N.C., Pfundt R., Lau Y.L. and Chung B.H.Y., Exome sequencing for paediatric-onset diseases: impact of the extensive involvement of medical geneticists in the diagnostic odyssey, npj Genomic Medicine. 2018, 3. |
| McDonell L.M., Leung K.C., Daoud H., Ip J.K.J., Chim S., Luk H.M., Lan C.L.L., Boycott K.M. and Chung B.H.Y., Mosaic KRAS mutation in a patient with encephalocraniocutaneous lipomatosis and renovascular hypertension , American Journal of Medical Genetics Part A. 2018. |
| TSANG H.Y., Kwong B.M.H., Pei L.C.S., Leung K.C., Yeung K.S., MAK C.C.Y., YU H.C., Fung L.F., Liang R., Chung B.H.Y. and Chan H.S.S., Application of whole exome sequencing in neuromuscular disorders patients in Hong Kong, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018. 17. |
| TSANG H.Y., Leung K.C., Ho C.C.A., Yeung K.S., MAK C.C.Y., Pei L.C.S., YU H.C., Kan S.Y.A., Chan Y.K., Kwong K.L., Lee S.L., Yung A.W.Y., Fung C.W. and Chung B.H.Y., Exome sequencing identifies molecular diagnosis in children with drug-resistant epilepsy, Epilepsia Open. 2018. |
| Yeung K.S., Ho S.P., Lee S.L., Kan S.Y.A., Chan Y.K., Tang M.H.Y., MAK C.C.Y., Leung K.C., So P.L., Pfundt R., Marshall C.R., Scherer S.W., Choufani S., Weksberg R. and Chung B.H.Y., Paternal uniparental disomy of chromosome 19 in a pair of monochorionic diamniotic twins with dysmorphic features and developmental delay, Journal of Medical Genetics. 2018, jmedgenet-2018-105328. |
| Yu K.P.T., Luk H.M., Leung K.C., Mak C.C.Y., Cheng S.S.W., Hau E.W.L., Chan D.K.H., Lam S.T.S., Tong T.M.F., Chung B.H.Y. and Lo F.M.I., Genetic landscape of RASopathies in Chinese: Three decades' experience in Hong Kong, American Journal of Medical Genetics Part C: Seminars in Medical Genetics. 2019. |
| Researcher : Leung TNH |
| List of Research Outputs |
| Hon K.L., Bao Y.M., Chan K.C., Chau K.W., Chen R.S., Cheok K.T., Chiu W.K., Li D., He C.H., Leong K.M., Kung J.S., Lam P., Lam S.Y., Lee Q.U., Lee S.L., Leung T.F., Leung T.N.H., Shi L., Siu K.K., Tan W.P., Wang M.H., Wong T.W., Wu B.J., Yip Y.F., Zheng Y.J. and Ng D.K., Determinants for asthma control, quality of life and use of complementary and alternative medicine in asthmatic pediatric patients in four cities, World Journal of Pediatrics. 2018. |
| Hon K.L., Leong K.F., Leung T.N.H. and Leung A.K.C., Dismissing the fallacies of childhood eczema management: case scenarios and an overview of best practices, Drugs in Context. 2018, 7: 1-12. |
| Hon K.L., Leung A.K.C., Leung T.N.H. and Lee V.W.Y., Investigational drugs for atopic dermatitis, Expert Opinion on Investigational Drugs. 2018, 27: 637-647. |
| Leung A.K.C., Hon K.L. and Leung T.N.H., Febrile seizures: an overview, Drugs in Context. 2018, 7: 1-12. |
| Leung T.N.H., Approach to a snoring child in primary care setting, Hong Kong College of Family Physicians 38th Annual Refresher Course. 2018. |
| Leung T.N.H., Clinical Guidelines on Management of Atopic Dermatitis in Children - An Update for practice, Annual Scientific meeting of Hong Kong Paediatric and Adolescent Dermatology Society March 2019. 2019. |
| Leung T.N.H., Hon K.L. and Leung A.K.C., Group A Streptococcus disease in Hong Kong children: an overview, Hong Kong Medical Journal. 2018. |
| Leung T.N.H., Interventions for Atopic Dermatitis to Prevent Allergy March, Scientific Symposium (Hong Kong Society of Paediatric Respiratory and Allergy) on Allergy Management 14 June 2019. 2019. |
| Leung T.N.H., Steroid Phobia and Management Issues of Atopic Dermatitis - The Hong Kong Perspective, Scientific Lunch Seminar on Atopic Dermatitis (Hong Kong Paediatric and Adolescent Dermatology Society and Hong Kong College of Family Physician. 2019. |
| Researcher : Li CB |
| Project Title: | The role of c-Myc in anti-mycobaterial responses: from bacterial killing to T cell activation |
| Investigator(s): | Li CB, Chan GCF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 02/2014 |
| Project Title: | A role for interleukin-17A in influenza virus induced immune responses and viral replication |
| Investigator(s): | Li CB |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| Researcher : Li WYV |
| List of Research Outputs |
| LI W.Y.V., Cardiac Magnetic Resonance T1 Mapping in Adolescent and Young Adult Survivors of Childhood Cancers, Circ Cardiovasc Imaging. 2019, 12: e008453. |
| LI W.Y.V., Two- and three-dimensional myocardial strain imaging in the interrogation of sex differences in cardiac mechanics of long-term survivors of childhood cancers, Int J Cardiovasc Imaging. 2019, 35: 999-1007. |
| Li W.Y.V., Liu A.P.Y., So K.F., Ho K.K., Yau J.P., Cheuk K.L.D. and Cheung Y.F., 2D and 3D myocardial strain imaging fails to reveal sexual dimorphism of anthracycline-induced cardiotoxicity in long-term survivors of childhood cancers, European Heart Journal. 2018, 39. |
| Li W.Y.V., Liu A.P.Y., Wong W.H.S., Ho K.K., Yau J.P., Cheuk K.L.D. and Cheung Y.F., Left and right ventricular systolic and diastolic functional reserves are impaired in anthracycline-treated long-term survivors of childhood cancers, American Heart Association Scientific Sessions 2017. 2018, 136. |
| Li W.Y.V., Liu A.P.Y., Wong W.H.S., Ho K.K., Yau J.P., Cheuk K.L.D. and Cheung Y.F., Left and right ventricular systolic and diastolic functional reserves are impaired in anthracycline-treated long-term survivors of childhood cancers, J Am Soc Echocardiogr. 2019, 32: 277-285. |
| Li W.Y.V., Liu A.P.Y., Ho K.K., Yau J.P., Cheuk K.L.D. and Cheung Y.F., Resting and exercise arterial dysfunction in anthracycline-treated adult survivors of childhood cancers, Cardio-Oncology. 2018, 4: 9. |
| Li W.Y.V., Liu A.P.Y., So K.F., Ho K.K., Yau J.P., Cheuk K.L.D. and Cheung Y.F., Two- And Three-dimensional Myocardial Strain Imaging In The Interrogation Of Sex Differences In Cardiac Mechanics Of Long-term Survivors Of Childhood Cancers, Int J Cardiovasc Imaging. 2019, 35: 999-1007. |
| TONG X., LI W.Y.V., Liu A.P.Y., So K.F., Chan Q., Ho K.K.H., Yau J.P.W., Cheuk K.L.D., Cheung Y.F. and Ng M.Y., Cardiac Magnetic Resonance T1 Mapping in Adolescent and Young Adult Survivors of Childhood Cancers, Circulation: Cardiovascular Imaging. 2019, 12. |
| Researcher : Liang R |
| List of Research Outputs |
| Liang R., Law H.Y., Deng R., Boheler K., Chan H.S.S. and Chan G.C.F., Best Poster Presentation Award ‘Generation of Induced pluripotent stem cells from Peripheral Blood Mononuclear Cells of an X-linked Dilated Cardiomyopathy Patient. R Liang, MR Deng, AHY Law, K Boheler, SHS Chan*, GCF Chan*.[PI and supervisor], The 2nd Joint Annual Research and Scientific Meeting 2018. 2018. |
| Liang R., Deng R., Law H.Y., Chan H.S.S., Boheler K. and Chan G.C.F., Generation of Induced pluripotent stem cells from Peripheral Blood Mononuclear Cells of an X-linked Dilated Cardiomyopathy Patient., The 2nd Joint Annual Research & Scientific Meeting 2018. Hong Kong.. 2018. |
| TSANG H.Y., Kwong B.M.H., Pei L.C.S., Leung K.C., Yeung K.S., MAK C.C.Y., YU H.C., Fung L.F., Liang R., Chung B.H.Y. and Chan H.S.S., Application of whole exome sequencing in neuromuscular disorders patients in Hong Kong, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018. 17. |
| YANG X., LIANG R., Liu C.X., Liu A.J., Cheung M.P.L., Liu X.L., Man O.Y., Guan X., Lung H.L. and Cheung M.C.H., SOX9 is a dose-dependent metastatic fate determinant in melanoma, Journal of Experimental & Clinical Cancer Research. 2019, 38. |
| Zhi H., Ho H.T., Liang R., Chan H.S.S. and Ip Y.T., THE IMPACT OF PAEDIATRIC NEUROMUSCULAR DISORDERS ON PARENTS’ HEALTH-RELATED QUALITY OF LIFE AND FAMILY FUNCTIONING, 2nd Joint Annual Research and Scientific Meeting 2018. |
| Researcher : Liu APY |
| List of Research Outputs |
| Kumar R., Liu A.P.Y., Orr B.A., Northcott P.A. and Robinson G.W., Advances in the classification of pediatric brain tumors through DNA methylation profiling: from research tool to frontline diagnostic, Cancer. 2018. |
| Kwok S.Y., Liu A.P.Y., Chan C.Y.Y., Lun K.S., Fung L.F., MAK C.C.Y., Chung B.H.Y. and Yung T.C., Clinical and genetic profile of congenital long QT syndrome in Hong Kong: a 20-year experience in paediatrics, Hong Kong Medical Journal. 2018. |
| Leung K.C., MAK C.C.Y., Fung L.F., Wong W.H.S., TSANG H.Y., YU H.C., Pei L.C.S., Yeung K.S., Mok T.K.G., Lee C.P., Hui P.W., Tang M.H.Y., Chan Y.K., Liu A.P.Y., Yang W., Sham P.C., Kan S.Y.A. and Chung B.H.Y., Identifying the genetic causes for prenatally diagnosed structural congenital anomalies (SCAs) by whole-exome sequencing (WES), BMC Medical Genomics. 2018, 11. |
| Li W.Y.V., Liu A.P.Y., So K.F., Ho K.K., Yau J.P., Cheuk K.L.D. and Cheung Y.F., 2D and 3D myocardial strain imaging fails to reveal sexual dimorphism of anthracycline-induced cardiotoxicity in long-term survivors of childhood cancers, European Heart Journal. 2018, 39. |
| Li W.Y.V., Liu A.P.Y., Wong W.H.S., Ho K.K., Yau J.P., Cheuk K.L.D. and Cheung Y.F., Left and right ventricular systolic and diastolic functional reserves are impaired in anthracycline-treated long-term survivors of childhood cancers, American Heart Association Scientific Sessions 2017. 2018, 136. |
| Li W.Y.V., Liu A.P.Y., Wong W.H.S., Ho K.K., Yau J.P., Cheuk K.L.D. and Cheung Y.F., Left and right ventricular systolic and diastolic functional reserves are impaired in anthracycline-treated long-term survivors of childhood cancers, J Am Soc Echocardiogr. 2019, 32: 277-285. |
| Li W.Y.V., Liu A.P.Y., Ho K.K., Yau J.P., Cheuk K.L.D. and Cheung Y.F., Resting and exercise arterial dysfunction in anthracycline-treated adult survivors of childhood cancers, Cardio-Oncology. 2018, 4: 9. |
| Li W.Y.V., Liu A.P.Y., So K.F., Ho K.K., Yau J.P., Cheuk K.L.D. and Cheung Y.F., Two- And Three-dimensional Myocardial Strain Imaging In The Interrogation Of Sex Differences In Cardiac Mechanics Of Long-term Survivors Of Childhood Cancers, Int J Cardiovasc Imaging. 2019, 35: 999-1007. |
| Liu A.P.Y., Harreld J.H., Jacola L.M., Gero M., Acharya S., Ghazwani Y., Wu S., Li X., Klimo P., Gajjar A., Chiang J. and Qaddoumi I., Tectal glioma as a distinct diagnostic entity: a comprehensive clinical, imaging, histologic and molecular analysis, Acta Neuropathologica Communications. 2018, 6. |
| Liu A.P.Y., Ip J.K.J., Leung A.W.K., Luk C.W., Li C.H., Ho K.K.H., Lo C.L.R., Chan E.K.W., Chan A.C.Y., Chung H.Y. and Chiang A.K.S., Treatment outcome and pattern of failure in hepatoblastoma treated with a consensus protocol in Hong Kong, Pediatric Blood & Cancer. 2018, 66(1): e27482. |
| TONG X., LI W.Y.V., Liu A.P.Y., So K.F., Chan Q., Ho K.K.H., Yau J.P.W., Cheuk K.L.D., Cheung Y.F. and Ng M.Y., Cardiac Magnetic Resonance T1 Mapping in Adolescent and Young Adult Survivors of Childhood Cancers, Circulation: Cardiovascular Imaging. 2019, 12. |
| Tso W.Y.W., Liu A.P.Y., Lee T.M.C., Cheuk K.L., Shing M.K., Luk C.W., Ling S.C., Ku D.T.L., Li K., Yung A., Fung C.W., Chan S.H.S., Ho A.C.C., Ho K.W.F., Ip P. and Chan G.C.F., Neurocognitive function, performance status, and quality of life in pediatric intracranial germ cell tumor survivors, Journal of Neuro-Oncology. 2019, 141: 393-401. |
| Zayts O.A., Shipman H.E., Fung L.F., Liu A.P.Y., Kwok S.Y., Tsai A.C.H., Yung T.C. and Chung B.H.Y., The different facets of “culture” in genetic counseling: A situated analysis of genetic counseling in Hong Kong, American Journal of Medical Genetics Part C: Seminars in Medical Genetics. 2019. |
| Researcher : Liu H |
| List of Research Outputs |
| Liu H., PENG L., So J., Tsang K.H., Chong C.H., Mak H.S., Chan K.M. and Chan S.Y., TSPYL2 regulates the expression of EZH2 target genes in neurons, Molecular Neurobiology . 2018. |
| Researcher : Liu Y |
| List of Research Outputs |
| Lam K.T., Xiang Z., Liu Y., WANG X. and Tu W., Human Vγ9Vδ2-T cells exhibit potent antiviral activity against EV71 infection, Immunology 2019. |
| Researcher : Lo FMI |
| List of Research Outputs |
| Cheng S.S.W., Chan Y.K., Leung K.K.P., Au P.K.C., Tam W.K., Li S.K.M., Luk H.M., Kan S.Y.A., Chung B.H.Y., Lo F.M.I. and Tang M.H.Y., Experience of chromosomal microarray applied in prenatal and postnatal settings in Hong Kong, American Journal of Medical Genetics Part C: Seminars in Medical Genetics. 2019. |
| Leung K.C., Luk H.M., Tang H.M.V., Gao W., MAK C.C.Y., YU H.C., Wong W.L., Chu W.Y., Yang W., Wong W.H.S., Ma C.H., Leung A.Y.H., Jin D., Chan Y.K., Allanson J., Lo F.M.I. and Chung B.H.Y., Integrating Functional Analysis in the Next-Generation Sequencing Diagnostic Pipeline of RASopathies, Scientific Reports. 2018, 8: 2421. |
| So P.L., Cheng Y.K.Y., Cheuk K.Y., Chiu W.K., Mak S.L., Mok S.L., Lo T.K., Yung W.K., Lo F.M.I., Chung B.H.Y., Kan S.Y.A., Lee C.P. and Tang M.H.Y., Health professionals’ involvement and information provision in genetic counseling following prenatal diagnosis of sex chromosome aneuploidy in Hong Kong, International Journal of Gynecology & Obstetrics. 2019, 144: 314-316. |
| Yu K.P.T., Luk H.M., Leung K.C., Mak C.C.Y., Cheng S.S.W., Hau E.W.L., Chan D.K.H., Lam S.T.S., Tong T.M.F., Chung B.H.Y. and Lo F.M.I., Genetic landscape of RASopathies in Chinese: Three decades' experience in Hong Kong, American Journal of Medical Genetics Part C: Seminars in Medical Genetics. 2019. |
| Yu K.P.T., Luk H.M., Chung B.H.Y. and Lo F.M.I., Myhre syndrome: a report of six Chinese patients and literature review, Clinical Dysmorphology. 2019, 1. |
| Researcher : Low LCK |
| Project Title: | 12th Asia Pacific Congress of Paediatrics and 2nd Asia Pacific Congress of Paediatric Nursing The Role of Nutritional Intake and Total Energy Expenditure on Early Growth of Babies Born with Intrauterine Growth Retardation |
| Investigator(s): | Low CKL |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2006 |
| Researcher : Luk HM |
| List of Research Outputs |
| Cheng S.S.W., Chan Y.K., Leung K.K.P., Au P.K.C., Tam W.K., Li S.K.M., Luk H.M., Kan S.Y.A., Chung B.H.Y., Lo F.M.I. and Tang M.H.Y., Experience of chromosomal microarray applied in prenatal and postnatal settings in Hong Kong, American Journal of Medical Genetics Part C: Seminars in Medical Genetics. 2019. |
| Leung K.C., Luk H.M., Tang H.M.V., Gao W., MAK C.C.Y., YU H.C., Wong W.L., Chu W.Y., Yang W., Wong W.H.S., Ma C.H., Leung A.Y.H., Jin D., Chan Y.K., Allanson J., Lo F.M.I. and Chung B.H.Y., Integrating Functional Analysis in the Next-Generation Sequencing Diagnostic Pipeline of RASopathies, Scientific Reports. 2018, 8: 2421. |
| Yu K.P.T., Luk H.M., Leung K.C., Mak C.C.Y., Cheng S.S.W., Hau E.W.L., Chan D.K.H., Lam S.T.S., Tong T.M.F., Chung B.H.Y. and Lo F.M.I., Genetic landscape of RASopathies in Chinese: Three decades' experience in Hong Kong, American Journal of Medical Genetics Part C: Seminars in Medical Genetics. 2019. |
| Yu K.P.T., Luk H.M., Chung B.H.Y. and Lo F.M.I., Myhre syndrome: a report of six Chinese patients and literature review, Clinical Dysmorphology. 2019, 1. |
| Researcher : Lun KS |
| List of Research Outputs |
| Kwok S.Y., Liu A.P.Y., Chan C.Y.Y., Lun K.S., Fung L.F., MAK C.C.Y., Chung B.H.Y. and Yung T.C., Clinical and genetic profile of congenital long QT syndrome in Hong Kong: a 20-year experience in paediatrics, Hong Kong Medical Journal. 2018. |
| Kwong K.Y., Chiu T.A., TSANG H.Y., Lun K.S., Rodenburg R.J.T., Smeitink J., Chung B.H.Y. and Fung C.W., A fatal case of COQ7-associated primary coenzyme Q10 deficiency , JIMD Reports. 2019, 47: 23-29. |
| Researcher : MAK CCY |
| List of Research Outputs |
| Chan H.S.S., Van Alfen N., Thuestad I.J., Ip J.K.J., Chan A.O.K., MAK C.C.Y., Chung B.H.Y., Aad V.E.R.R.I.P.S. and Erik-Jan K.A.M.S.T.E.E.G., A recurrent de novo DYNC1H1 tail domain mutation causes spinal muscular atrophy with lower extremity predominance, learning difficulties and mild brain abnormality, Neuromuscular Disorders. 2018. |
| Fung L.F., TSANG H.Y., Leung K.C., Yeung K.S., MAK C.C.Y., Fung C.W., Chan H.S.S., YU H.C. and Chung B.H.Y., A significant inflation in TGM6 genetic risk casts doubt in its causation in spinocerebellar ataxia type 35, Parkinsonism & Related Disorders. 2019. |
| Kwok S.Y., Liu A.P.Y., Chan C.Y.Y., Lun K.S., Fung L.F., MAK C.C.Y., Chung B.H.Y. and Yung T.C., Clinical and genetic profile of congenital long QT syndrome in Hong Kong: a 20-year experience in paediatrics, Hong Kong Medical Journal. 2018. |
| Leung K.C., Mak C.C.Y., Doherty D., Lin A., Vegas N., Cho M., Dimartino C., Weisfeld-Adams J., Lessel D., Joss S., Li C., Gonzaga-Jauregui C., Zarate Y., Troyer C., Kant S., Leung G., Barone A., Yang S., Bend E., Roadhouse C., Zahir F., Stolerman E., Bienvenu T., Orenstein N., Dobyns W., Shieh J., Waggoner D., Gripp K., Parker M., Stoler J., Lyonnet S., Cormiere-Daire V., Viskochil D., Hoffman T., Amiel J. and Chung B.H.Y., De novo C-terminal truncating mutations in MN1 cause a neurodevelopmental syndrome with distinctive facial features., European Human Genetics Conference, Gothenburg, Sweden, 15-18 June 2019. |
| Leung K.C., MAK C.C.Y., Fung L.F., Wong W.H.S., TSANG H.Y., YU H.C., Pei L.C.S., Yeung K.S., Mok T.K.G., Lee C.P., Hui P.W., Tang M.H.Y., Chan Y.K., Liu A.P.Y., Yang W., Sham P.C., Kan S.Y.A. and Chung B.H.Y., Identifying the genetic causes for prenatally diagnosed structural congenital anomalies (SCAs) by whole-exome sequencing (WES), BMC Medical Genomics. 2018, 11. |
| Leung K.C., Luk H.M., Tang H.M.V., Gao W., MAK C.C.Y., YU H.C., Wong W.L., Chu W.Y., Yang W., Wong W.H.S., Ma C.H., Leung A.Y.H., Jin D., Chan Y.K., Allanson J., Lo F.M.I. and Chung B.H.Y., Integrating Functional Analysis in the Next-Generation Sequencing Diagnostic Pipeline of RASopathies, Scientific Reports. 2018, 8: 2421. |
| MAK C.C.Y., Leung K.C., Mok T.K.G., Yeung K.S., Yang W., Fung C.W., Chan H.S.S., Lee S.L., Lee N.C., Pfundt R., Lau Y.L. and Chung B.H.Y., Exome sequencing for paediatric-onset diseases: impact of the extensive involvement of medical geneticists in the diagnostic odyssey, npj Genomic Medicine. 2018, 3. |
| TSANG H.Y., Kwong B.M.H., Pei L.C.S., Leung K.C., Yeung K.S., MAK C.C.Y., YU H.C., Fung L.F., Liang R., Chung B.H.Y. and Chan H.S.S., Application of whole exome sequencing in neuromuscular disorders patients in Hong Kong, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018. 17. |
| TSANG H.Y., Leung K.C., Ho C.C.A., Yeung K.S., MAK C.C.Y., Pei L.C.S., YU H.C., Kan S.Y.A., Chan Y.K., Kwong K.L., Lee S.L., Yung A.W.Y., Fung C.W. and Chung B.H.Y., Exome sequencing identifies molecular diagnosis in children with drug-resistant epilepsy, Epilepsia Open. 2018. |
| Yeung K.S., Lee T.L., Mok M.Y., Mak C.C.Y., Yang W., Chong C.Y., Lee P.P.W., Ho M.H.K., Choufani S., Lau W.C.S., Lau Y.L., Weksberg R. and Chung B.H.Y., Cell Lineage-specific Genome-wide DNA Methylation Analysis of Patients with Paediatric-onset Systemic Lupus Erythematosus, Epigenetics. 2019. |
| Yeung K.S., Ho S.P., Lee S.L., Kan S.Y.A., Chan Y.K., Tang M.H.Y., MAK C.C.Y., Leung K.C., So P.L., Pfundt R., Marshall C.R., Scherer S.W., Choufani S., Weksberg R. and Chung B.H.Y., Paternal uniparental disomy of chromosome 19 in a pair of monochorionic diamniotic twins with dysmorphic features and developmental delay, Journal of Medical Genetics. 2018, jmedgenet-2018-105328. |
| Yu K.P.T., Luk H.M., Leung K.C., Mak C.C.Y., Cheng S.S.W., Hau E.W.L., Chan D.K.H., Lam S.T.S., Tong T.M.F., Chung B.H.Y. and Lo F.M.I., Genetic landscape of RASopathies in Chinese: Three decades' experience in Hong Kong, American Journal of Medical Genetics Part C: Seminars in Medical Genetics. 2019. |
| Researcher : Ma CH |
| Project Title: | The role of calreticulin in normal hematopoiesis and myeloproliferative neoplasms |
| Investigator(s): | Ma CH |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2015 |
| Project Title: | Developing an in vivo zebrafish platform for functional evaluation of recurrent mutations in acute myeloid leukemia (AML) and primary screening of novel targeted therapeutic agents |
| Investigator(s): | Ma CH, Leung AYH |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2015 |
| Project Title: | Generating transgenic zebrafish model to study the emerging role of autophagy and mitophagy in hematopoietic diseases |
| Investigator(s): | Ma CH, Leung AYH |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2016 |
| List of Research Outputs |
| Leung K.C., Luk H.M., Tang H.M.V., Gao W., MAK C.C.Y., YU H.C., Wong W.L., Chu W.Y., Yang W., Wong W.H.S., Ma C.H., Leung A.Y.H., Jin D., Chan Y.K., Allanson J., Lo F.M.I. and Chung B.H.Y., Integrating Functional Analysis in the Next-Generation Sequencing Diagnostic Pipeline of RASopathies, Scientific Reports. 2018, 8: 2421. |
| Researcher : Mak CCY |
| List of Research Outputs |
| Chan H.S.S., Van Alfen N., Thuestad I.J., Ip J.K.J., Chan A.O.K., MAK C.C.Y., Chung B.H.Y., Aad V.E.R.R.I.P.S. and Erik-Jan K.A.M.S.T.E.E.G., A recurrent de novo DYNC1H1 tail domain mutation causes spinal muscular atrophy with lower extremity predominance, learning difficulties and mild brain abnormality, Neuromuscular Disorders. 2018. |
| Fung L.F., TSANG H.Y., Leung K.C., Yeung K.S., MAK C.C.Y., Fung C.W., Chan H.S.S., YU H.C. and Chung B.H.Y., A significant inflation in TGM6 genetic risk casts doubt in its causation in spinocerebellar ataxia type 35, Parkinsonism & Related Disorders. 2019. |
| Kwok S.Y., Liu A.P.Y., Chan C.Y.Y., Lun K.S., Fung L.F., MAK C.C.Y., Chung B.H.Y. and Yung T.C., Clinical and genetic profile of congenital long QT syndrome in Hong Kong: a 20-year experience in paediatrics, Hong Kong Medical Journal. 2018. |
| Leung K.C., Mak C.C.Y., Doherty D., Lin A., Vegas N., Cho M., Dimartino C., Weisfeld-Adams J., Lessel D., Joss S., Li C., Gonzaga-Jauregui C., Zarate Y., Troyer C., Kant S., Leung G., Barone A., Yang S., Bend E., Roadhouse C., Zahir F., Stolerman E., Bienvenu T., Orenstein N., Dobyns W., Shieh J., Waggoner D., Gripp K., Parker M., Stoler J., Lyonnet S., Cormiere-Daire V., Viskochil D., Hoffman T., Amiel J. and Chung B.H.Y., De novo C-terminal truncating mutations in MN1 cause a neurodevelopmental syndrome with distinctive facial features., European Human Genetics Conference, Gothenburg, Sweden, 15-18 June 2019. |
| Leung K.C., MAK C.C.Y., Fung L.F., Wong W.H.S., TSANG H.Y., YU H.C., Pei L.C.S., Yeung K.S., Mok T.K.G., Lee C.P., Hui P.W., Tang M.H.Y., Chan Y.K., Liu A.P.Y., Yang W., Sham P.C., Kan S.Y.A. and Chung B.H.Y., Identifying the genetic causes for prenatally diagnosed structural congenital anomalies (SCAs) by whole-exome sequencing (WES), BMC Medical Genomics. 2018, 11. |
| Leung K.C., Luk H.M., Tang H.M.V., Gao W., MAK C.C.Y., YU H.C., Wong W.L., Chu W.Y., Yang W., Wong W.H.S., Ma C.H., Leung A.Y.H., Jin D., Chan Y.K., Allanson J., Lo F.M.I. and Chung B.H.Y., Integrating Functional Analysis in the Next-Generation Sequencing Diagnostic Pipeline of RASopathies, Scientific Reports. 2018, 8: 2421. |
| MAK C.C.Y., Leung K.C., Mok T.K.G., Yeung K.S., Yang W., Fung C.W., Chan H.S.S., Lee S.L., Lee N.C., Pfundt R., Lau Y.L. and Chung B.H.Y., Exome sequencing for paediatric-onset diseases: impact of the extensive involvement of medical geneticists in the diagnostic odyssey, npj Genomic Medicine. 2018, 3. |
| TSANG H.Y., Kwong B.M.H., Pei L.C.S., Leung K.C., Yeung K.S., MAK C.C.Y., YU H.C., Fung L.F., Liang R., Chung B.H.Y. and Chan H.S.S., Application of whole exome sequencing in neuromuscular disorders patients in Hong Kong, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018. 17. |
| TSANG H.Y., Leung K.C., Ho C.C.A., Yeung K.S., MAK C.C.Y., Pei L.C.S., YU H.C., Kan S.Y.A., Chan Y.K., Kwong K.L., Lee S.L., Yung A.W.Y., Fung C.W. and Chung B.H.Y., Exome sequencing identifies molecular diagnosis in children with drug-resistant epilepsy, Epilepsia Open. 2018. |
| Yeung K.S., Lee T.L., Mok M.Y., Mak C.C.Y., Yang W., Chong C.Y., Lee P.P.W., Ho M.H.K., Choufani S., Lau W.C.S., Lau Y.L., Weksberg R. and Chung B.H.Y., Cell Lineage-specific Genome-wide DNA Methylation Analysis of Patients with Paediatric-onset Systemic Lupus Erythematosus, Epigenetics. 2019. |
| Yeung K.S., Ho S.P., Lee S.L., Kan S.Y.A., Chan Y.K., Tang M.H.Y., MAK C.C.Y., Leung K.C., So P.L., Pfundt R., Marshall C.R., Scherer S.W., Choufani S., Weksberg R. and Chung B.H.Y., Paternal uniparental disomy of chromosome 19 in a pair of monochorionic diamniotic twins with dysmorphic features and developmental delay, Journal of Medical Genetics. 2018, jmedgenet-2018-105328. |
| Yu K.P.T., Luk H.M., Leung K.C., Mak C.C.Y., Cheng S.S.W., Hau E.W.L., Chan D.K.H., Lam S.T.S., Tong T.M.F., Chung B.H.Y. and Lo F.M.I., Genetic landscape of RASopathies in Chinese: Three decades' experience in Hong Kong, American Journal of Medical Genetics Part C: Seminars in Medical Genetics. 2019. |
| Researcher : Mak HS |
| List of Research Outputs |
| Liu H., PENG L., So J., Tsang K.H., Chong C.H., Mak H.S., Chan K.M. and Chan S.Y., TSPYL2 regulates the expression of EZH2 target genes in neurons, Molecular Neurobiology . 2018. |
| Researcher : Mao H |
| List of Research Outputs |
| Luk A.D.W., NI K., Wu Y., Lam K.T., Chan K.W., Lee P.P.W., Tu W., Mao H. and Lau Y.L., Type I and III Interferon Productions Are Impaired in X-Linked Agammaglobulinemia Patients Toward Poliovirus but Not Influenza Virus, Frontiers in Immunology. 2018, 9. |
| Researcher : Mok TKG |
| List of Research Outputs |
| Leung K.C., MAK C.C.Y., Fung L.F., Wong W.H.S., TSANG H.Y., YU H.C., Pei L.C.S., Yeung K.S., Mok T.K.G., Lee C.P., Hui P.W., Tang M.H.Y., Chan Y.K., Liu A.P.Y., Yang W., Sham P.C., Kan S.Y.A. and Chung B.H.Y., Identifying the genetic causes for prenatally diagnosed structural congenital anomalies (SCAs) by whole-exome sequencing (WES), BMC Medical Genomics. 2018, 11. |
| MAK C.C.Y., Leung K.C., Mok T.K.G., Yeung K.S., Yang W., Fung C.W., Chan H.S.S., Lee S.L., Lee N.C., Pfundt R., Lau Y.L. and Chung B.H.Y., Exome sequencing for paediatric-onset diseases: impact of the extensive involvement of medical geneticists in the diagnostic odyssey, npj Genomic Medicine. 2018, 3. |
| Researcher : NI K |
| List of Research Outputs |
| Luk A.D.W., NI K., Wu Y., Lam K.T., Chan K.W., Lee P.P.W., Tu W., Mao H. and Lau Y.L., Type I and III Interferon Productions Are Impaired in X-Linked Agammaglobulinemia Patients Toward Poliovirus but Not Influenza Virus, Frontiers in Immunology. 2018, 9. |
| Researcher : PENG L |
| List of Research Outputs |
| Liu H., PENG L., So J., Tsang K.H., Chong C.H., Mak H.S., Chan K.M. and Chan S.Y., TSPYL2 regulates the expression of EZH2 target genes in neurons, Molecular Neurobiology . 2018. |
| Magni M., Buscemi G., Maita L., PENG L. and Chan S.Y., TSPYL2 is a novel regulator of SIRT1 and p300 activity in response to DNA damage, Cell Death and Differentiation . 2018. |
| Researcher : Pei LCS |
| List of Research Outputs |
| Leung K.C., MAK C.C.Y., Fung L.F., Wong W.H.S., TSANG H.Y., YU H.C., Pei L.C.S., Yeung K.S., Mok T.K.G., Lee C.P., Hui P.W., Tang M.H.Y., Chan Y.K., Liu A.P.Y., Yang W., Sham P.C., Kan S.Y.A. and Chung B.H.Y., Identifying the genetic causes for prenatally diagnosed structural congenital anomalies (SCAs) by whole-exome sequencing (WES), BMC Medical Genomics. 2018, 11. |
| TSANG H.Y., Kwong B.M.H., Pei L.C.S., Leung K.C., Yeung K.S., MAK C.C.Y., YU H.C., Fung L.F., Liang R., Chung B.H.Y. and Chan H.S.S., Application of whole exome sequencing in neuromuscular disorders patients in Hong Kong, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018. 17. |
| TSANG H.Y., Leung K.C., Ho C.C.A., Yeung K.S., MAK C.C.Y., Pei L.C.S., YU H.C., Kan S.Y.A., Chan Y.K., Kwong K.L., Lee S.L., Yung A.W.Y., Fung C.W. and Chung B.H.Y., Exome sequencing identifies molecular diagnosis in children with drug-resistant epilepsy, Epilepsia Open. 2018. |
| YU H.C., TSANG H.Y., Pei L.C.S., Chan V.C.M., Rodenburg R.J.T., Smeitink J., Lee N.N.C., Fung C.W. and Chung B.H.Y., COQ10 deficiency due to biallelic COQ4 mutations – An early onset mitochondrial disorder common in southern Chinese due to a founder mutation, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018. (Award for oral presentation - 2nd prize). 2018, 20. |
| Researcher : Poon WYS |
| List of Research Outputs |
| Poon W.Y.S., Tung Y.L. and Chung B.H.Y., A case of pituitary stalk interruption syndrome caused by mutation in robo1 gene presenting with early onset growth failure, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018.. 2018. |
| Researcher : Shen JJ |
| List of Research Outputs |
| Chan T.F., Hui K.F., Yang W., Shen J.J., Lam K.P., Kwok H., Sham P.C., Tsao G.S.W., Kwong D.L.W., Lung M.L. and Chiang A.K.S., Genome-wide analysis identifies high-risk Epstein-Barr virus associated with nasopharyngeal carcinoma., HKU Research Postgraduate Seminar, December 5-7, 2018.. 2018. |
| Hui K.F., CHAN T.F., Yang W., Shen J.J., Lam K.P., Kwok H.I.N., Sham P.C., Tsao G.S.W., Kwong D.L.W., Lung M.L. and Chiang A.K.S., High risk Epstein‐Barr virus variants characterized by distinct polymorphisms in the EBER locus are strongly associated with nasopharyngeal carcinoma, International Journal of Cancer. 2019, 144: 3031-3042. |
| Wang Y., Zhang Y., Zhu Z., Wang T., Morris D.L., Shen J.J., Zhang H., Pan H.F., Yang J., Yang S., Ye D.Q., Vyse T.J., Cui Y., Zhang X., Sheng Y., Lau Y.L. and Yang W., Identification of ST3AGL4 , MFHAS1, CSNK2A2 and CD226 as loci associated with systemic lupus erythematosus (SLE) and evaluation of SLE genetics in drug repositioning , Annals of the Rheumatic Diseases. 2018, 77: 1078-1084. |
| ZHANG H., ZHANG Y., Wang Y., Morris D., Hirankarn N., Sheng Y., Shen J.J., Pan H.F., Yang J., Yang S., Cui Y., Ye D.Q., Vyse T.J., Zhang X., Lau Y.L. and Yang W., Meta-analysis of GWAS on both Chinese and European populations identifies GPR173 as a novel X chromosome susceptibility gene for SLE, Arthritis Research & Therapy. 2018, 20. |
| Researcher : So HK |
| List of Research Outputs |
| Chan D.F.Y., So H.K., Hui S.C.N., Chan R.S.M., Li A.M., Sea M.M., Chu W.C.W., Chan M., Woo J. and Nelson E.A.S., Dietitian-led lifestyle modification programme for obese Chinese adolescents with non-alcoholic fatty liver disease: a randomized controlled study, International Journal of Obesity. 2018, 42: 1680-1690. |
| Hui S.C.N., So H.K., Chan D.F.Y., Wong S.K.H., Yeung D.K.W., Ng E.K.W. and Chu W.C.W., Validation of water-fat MRI and proton MRS in assessment of hepatic fat and the heterogeneous distribution of hepatic fat and iron in subjects with non-alcoholic fatty liver disease, European Journal of Radiology. 2018, 107: 7-13. |
| Lam T.H., Ho D.S.Y., So H.K. and et al , Rising rural body-mass index is the main driver of the global obesity epidemic in adults, Nature. 2019, 569(7755): 260-4. |
| Yu C.C.W., McManus A. .M., Au C.T., So H.K., Chan A., Sung R.Y.T., Li A.M. and Passino C., Appropriate scaling approach for evaluating peak VO2 development in Southern Chinese 8 to 16 years old, PLOS ONE. 2019, 14: e0213674. |
| Researcher : So J |
| List of Research Outputs |
| Liu H., PENG L., So J., Tsang K.H., Chong C.H., Mak H.S., Chan K.M. and Chan S.Y., TSPYL2 regulates the expression of EZH2 target genes in neurons, Molecular Neurobiology . 2018. |
| Researcher : So KF |
| List of Research Outputs |
| Li W.Y.V., Liu A.P.Y., So K.F., Ho K.K., Yau J.P., Cheuk K.L.D. and Cheung Y.F., 2D and 3D myocardial strain imaging fails to reveal sexual dimorphism of anthracycline-induced cardiotoxicity in long-term survivors of childhood cancers, European Heart Journal. 2018, 39. |
| Li W.Y.V., Liu A.P.Y., So K.F., Ho K.K., Yau J.P., Cheuk K.L.D. and Cheung Y.F., Two- And Three-dimensional Myocardial Strain Imaging In The Interrogation Of Sex Differences In Cardiac Mechanics Of Long-term Survivors Of Childhood Cancers, Int J Cardiovasc Imaging. 2019, 35: 999-1007. |
| TONG X., LI W.Y.V., Liu A.P.Y., So K.F., Chan Q., Ho K.K.H., Yau J.P.W., Cheuk K.L.D., Cheung Y.F. and Ng M.Y., Cardiac Magnetic Resonance T1 Mapping in Adolescent and Young Adult Survivors of Childhood Cancers, Circulation: Cardiovascular Imaging. 2019, 12. |
| Researcher : Sou Da Rosa Duque J |
| List of Research Outputs |
| Sou Da Rosa Duque J., Chong C.Y., Lau Y.L. and Ho M.H.K., Cross-reactivity pattern of a rare presentation of generalized delayed-type hypersensitivity to local anaesthetics, Asian Pacific Journal Of Allergy And Immunology. 2018. |
| Sou Da Rosa Duque J., Cheuk K.L.D., Chong C.Y., Ip P., Wong W.H.S., Lee P.P.W., Wong I.C.K., Chan G.C.F., Lau Y.L. and Ho M.H.K., Older age and male gender as risk factors for IgE-mediated drug allergies in Chinese children, 10th Hong Kong Allergy Convention 2018. |
| Sou Da Rosa Duque J., Paediatric Immunology, Allergy and Infectious Diseases Study Day – Best Paper Award, The Hong Kong Society for Paediatric Immunology, Allergy and Infectious Diseases. 2018. |
| Sou Da Rosa Duque J., Paediatric Immunology, Allergy and Infectious Diseases Study Day – Case Presentation – 3rd Prize, The Hong Kong Society for Paediatric Immunology, Allergy and Infectious Diseases. 2018. |
| Researcher : TSANG HY |
| List of Research Outputs |
| Fung L.F., TSANG H.Y., Leung K.C., Yeung K.S., MAK C.C.Y., Fung C.W., Chan H.S.S., YU H.C. and Chung B.H.Y., A significant inflation in TGM6 genetic risk casts doubt in its causation in spinocerebellar ataxia type 35, Parkinsonism & Related Disorders. 2019. |
| Fung L.F., TSANG H.Y., YU H.C. and Chung B.H.Y., TGM6 variants in Chinese population – is it disease causing?, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018. |
| Kwong K.Y., Chiu T.A., TSANG H.Y., Lun K.S., Rodenburg R.J.T., Smeitink J., Chung B.H.Y. and Fung C.W., A fatal case of COQ7-associated primary coenzyme Q10 deficiency , JIMD Reports. 2019, 47: 23-29. |
| Leung K.C., MAK C.C.Y., Fung L.F., Wong W.H.S., TSANG H.Y., YU H.C., Pei L.C.S., Yeung K.S., Mok T.K.G., Lee C.P., Hui P.W., Tang M.H.Y., Chan Y.K., Liu A.P.Y., Yang W., Sham P.C., Kan S.Y.A. and Chung B.H.Y., Identifying the genetic causes for prenatally diagnosed structural congenital anomalies (SCAs) by whole-exome sequencing (WES), BMC Medical Genomics. 2018, 11. |
| TSANG H.Y., Kwong B.M.H., Pei L.C.S., Leung K.C., Yeung K.S., MAK C.C.Y., YU H.C., Fung L.F., Liang R., Chung B.H.Y. and Chan H.S.S., Application of whole exome sequencing in neuromuscular disorders patients in Hong Kong, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018. 17. |
| TSANG H.Y., Leung K.C., Ho C.C.A., Yeung K.S., MAK C.C.Y., Pei L.C.S., YU H.C., Kan S.Y.A., Chan Y.K., Kwong K.L., Lee S.L., Yung A.W.Y., Fung C.W. and Chung B.H.Y., Exome sequencing identifies molecular diagnosis in children with drug-resistant epilepsy, Epilepsia Open. 2018. |
| YU H.C., TSANG H.Y., Pei L.C.S., Chan V.C.M., Rodenburg R.J.T., Smeitink J., Lee N.N.C., Fung C.W. and Chung B.H.Y., COQ10 deficiency due to biallelic COQ4 mutations – An early onset mitochondrial disorder common in southern Chinese due to a founder mutation, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018. (Award for oral presentation - 2nd prize). 2018, 20. |
| Researcher : TUNG TS |
| List of Research Outputs |
| WONG R.S.M., Yu Y.T.E., Wong C.K.H., TUNG T.S., Wong W.H.S., Ip P. and Lam C.L.K., Associations between physical activity and health-related quality of life, behavior and telomere length among Chinese children from low-income families in Hong Kong, International Conference and Active Living and Health. 2018. |
| Researcher : Tsao SSL |
| List of Research Outputs |
| Tsao S.S.L., What is the optimal remote monitoring schedule in pediatric patients with cardiovascular implantable electronic devices?, Pacing and Clinical Electrophysiology. 2019. |
| Researcher : Tso WWY |
| Project Title: | The use of diffusion kurtosis imaging (DKI) to quantify brain microstructure alteration as predictor for neurocognitive and functional outcomes in childhood intracranial germinoma survivors |
| Investigator(s): | Tso WYW, Lee TMC, Fong DYT, Chan GCF, Khong PL, Hui SK |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Completion Date: | 12/2019 |
| Project Title: | The structural and functional brain connectivity in children with attention-deficit hyperactivity disorders: relationship with disease severity and Methylphenidate treatment |
| Investigator(s): | Tso WYW, Ip P, Khong PL, Vardhanabhuti V, Hui SK |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| List of Research Outputs |
| Researcher : Tso WYW |
| Project Title: | The use of diffusion kurtosis imaging (DKI) to quantify brain microstructure alteration as predictor for neurocognitive and functional outcomes in childhood intracranial germinoma survivors |
| Investigator(s): | Tso WYW, Lee TMC, Fong DYT, Chan GCF, Khong PL, Hui SK |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Completion Date: | 12/2019 |
| Project Title: | The structural and functional brain connectivity in children with attention-deficit hyperactivity disorders: relationship with disease severity and Methylphenidate treatment |
| Investigator(s): | Tso WYW, Ip P, Khong PL, Vardhanabhuti V, Hui SK |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| List of Research Outputs |
| Tso W.Y.W., Chan M.C.M., Ho F.K., Rao N., Li A.M., Chan K.L., Tiwari A.F.Y., Wong I.C.K., Wing Y.K., Van Voorhees B., Li S.L., Goh W.H.S. and Ip P., Early sleep deprivation and attention-deficit/hyperactivity disorder, Pediatric Research. 2019, 85: 449-455. |
| Tso W.Y.W., Liu A.P.Y., Lee T.M.C., Cheuk K.L., Shing M.K., Luk C.W., Ling S.C., Ku D.T.L., Li K., Yung A., Fung C.W., Chan S.H.S., Ho A.C.C., Ho K.W.F., Ip P. and Chan G.C.F., Neurocognitive function, performance status, and quality of life in pediatric intracranial germ cell tumor survivors, Journal of Neuro-Oncology. 2019, 141: 393-401. |
| Researcher : Tu W |
| Project Title: | Humanized mouse as a model to study the antiviral activity of human gammadelta-T cells against human and avian influenza A viruses in vivo |
| Investigator(s): | Tu W, Lau YL, Peiris JSM, Law HKW |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 08/2007 |
| Project Title: | Induction of tolerance by alloantigen-specific regulatory T cells in humanized mice and non-human primates |
| Investigator(s): | Tu W, Lau YL, Liu Y |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2012 |
| Project Title: | Costimulatory effect of 4-1BB signal in the antitumor activity of human gammadelta-T cells against EBV-induced lymphoproliferative disease |
| Investigator(s): | Tu W |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2017 |
| Project Title: | Roles of exosomes-induced IL-17-producing γδ-T cells in the development and progression of nasopharyngeal carcinoma |
| Investigator(s): | Tu W |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research for Resubmission of GRF/ECS Proposals |
| Start Date: | 07/2018 |
| Completion Date: | 11/2018 |
| List of Research Outputs |
| Lam K.T., Xiang Z., Liu Y., WANG X. and Tu W., Human Vγ9Vδ2-T cells exhibit potent antiviral activity against EV71 infection, Immunology 2019. |
| Luk A.D.W., NI K., Wu Y., Lam K.T., Chan K.W., Lee P.P.W., Tu W., Mao H. and Lau Y.L., Type I and III Interferon Productions Are Impaired in X-Linked Agammaglobulinemia Patients Toward Poliovirus but Not Influenza Virus, Frontiers in Immunology. 2018, 9. |
| Tu W., Application of humanized mice in translational Medical research, Sichuan Laboratory Medicine Conference. 31 October, 2018, Chengdu. 2018. |
| Tu W., Application of humanized mice in translational immunology research’, 7th National Respiratory Diseases Forum on Translational Medical Research. 27-28 April 2019, Yangzhou.. 2019. |
| Tu W., Application of humanized mice in transplantation Immunology, Transplantation Immunology Meeting Chinese Society for Immunology. 4-5 August 2018. Qingdao. 2018. |
| Tu W., Immunotherapy for EBV-associated Disorders, Great Bay Area Forum for Digestive diseases. 12 January 2019. Shenzhen. 2019. |
| Tu W., Immunotherapy for infectious diseases, Yunnan Annual Meeting for Pediatrics. 24-25 November 2018. Kunming. 2018. |
| Tu W., Immunotherapy for respiratory diseases, 2019 Zhoujiang Forum for Respiratory Diseases. 22-23 June, 2019, Guangzhou.. 2019. |
| Tu W., Immunotherapy for respiratory diseases, Great Bay Area Forum for Respiratory Diseases, 22-23 December, 2018, Guangzhou. 2018. |
| Tu W., Immunotherapy for respiratory diseases, Jiangsu Forum for Lung Diseases. 24-25 August 2018. Nanji.. 2018. |
| Tu W., The role of gammadelta-T cells in pregnancy, 2018 Sichuan Reproductive Medicine Conference, 2 November 2018, Chengdu. 2018. |
| Tu W., The role of gammadelta-T cells in pregnancy, Health China 2018. 11-12 October 2018. Chengdu. 2018. |
| Researcher : Tung YL |
| List of Research Outputs |
| Lai S.H.Y., Tung Y.L. and Chung B.H.Y., A girl with multiple epiphyseal dysplasia due to novel C.955G >T mutation in the cartilage oligomeric matrix protein, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018.. 2018, 47. |
| Poon W.Y.S., Tung Y.L. and Chung B.H.Y., A case of pituitary stalk interruption syndrome caused by mutation in robo1 gene presenting with early onset growth failure, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018.. 2018. |
| Researcher : WANG X |
| List of Research Outputs |
| Lam K.T., Xiang Z., Liu Y., WANG X. and Tu W., Human Vγ9Vδ2-T cells exhibit potent antiviral activity against EV71 infection, Immunology 2019. |
| Researcher : WONG OT |
| List of Research Outputs |
| Foo K.S., Lehtinen M.L., Leung C.Y., Lian X., Xu J., Keung W.W.Y., Geng L., Kolstad T.R.S., Thams S., WONG O.T., WONG N.C.S., Bylund K., Zhou C.S., He X., Jin S.-.B., Clarke J., Lendahl U., Li R.A., Louch W.E. and Chien K.R., Human ISL1 + Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction, Molecular Therapy. 2018, 26: 1644-1659. |
| Geng L., Kong M.C.W., WONG O.T., Shum A.M.Y., Chow M.Z.Y., Che H., Zhang C.Z., Yau K.L., Chan C.W.Y., Keung W.W.Y. and Li R.A., Probing flecainide block of INa using human pluripotent stem cell-derived ventricular cardiomyocytes adapted to automated patch-clamping and 2D monolayers, Toxicology Letters. 2018, 294: 61-72. |
| Researcher : Wang T |
| List of Research Outputs |
| Wang Y., Zhang Y., Zhu Z., Wang T., Morris D.L., Shen J.J., Zhang H., Pan H.F., Yang J., Yang S., Ye D.Q., Vyse T.J., Cui Y., Zhang X., Sheng Y., Lau Y.L. and Yang W., Identification of ST3AGL4 , MFHAS1, CSNK2A2 and CD226 as loci associated with systemic lupus erythematosus (SLE) and evaluation of SLE genetics in drug repositioning , Annals of the Rheumatic Diseases. 2018, 77: 1078-1084. |
| Researcher : Wang Y |
| List of Research Outputs |
| Wang Y., Zhang Y., Zhu Z., Wang T., Morris D.L., Shen J.J., Zhang H., Pan H.F., Yang J., Yang S., Ye D.Q., Vyse T.J., Cui Y., Zhang X., Sheng Y., Lau Y.L. and Yang W., Identification of ST3AGL4 , MFHAS1, CSNK2A2 and CD226 as loci associated with systemic lupus erythematosus (SLE) and evaluation of SLE genetics in drug repositioning , Annals of the Rheumatic Diseases. 2018, 77: 1078-1084. |
| Wang Y., Lau Y.L. and Yang W., Genetic studies on systemic lupus erythematosus in East Asia point to population differences in disease susceptibility, American Journal of Medical Genetics Part C: Seminars in Medical Genetics. 2019. |
| ZHANG H., ZHANG Y., Wang Y., Morris D., Hirankarn N., Sheng Y., Shen J.J., Pan H.F., Yang J., Yang S., Cui Y., Ye D.Q., Vyse T.J., Zhang X., Lau Y.L. and Yang W., Meta-analysis of GWAS on both Chinese and European populations identifies GPR173 as a novel X chromosome susceptibility gene for SLE, Arthritis Research & Therapy. 2018, 20. |
| Researcher : Willis BR |
| List of Research Outputs |
| Chung B.H.Y., Willis B.R. and Lai P.S., Development of clinical genetics in Asia, American Journal of Medical Genetics Part C: Seminars in Medical Genetics. 2019. |
| Researcher : Wong CNV |
| Project Title: | Rett Syndrome :Systematic screening of MECP2 in children with autistic traits and or unexplained mental retardation/ encephalopathy to define the spectrum of Rett Syndrome phenotypes resulting from mutations in MECP2 |
| Investigator(s): | Wong CNV |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2006 |
| Project Title: | A study of copy number variations (CNVs) of genes NRXN1, GRIN2A, GRIN2B and PCDH19 associated with synaptic function in Chinese children with infantile epileptic encephalopathies |
| Investigator(s): | Wong CNV, Kwong KY, Fung CW |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2014 |
| Researcher : Wong KY |
| List of Research Outputs |
| Chee W.Y.Y., Wong S.C.M., Wong R.M.S., Wong K.Y. and Lau C.T., Associated anomalies and clinical outcomes in infants with omphalocele: a single-centre 10-year review, Hong Kong Journal of Paediatrics. 2018, 23(3): 220-224. |
| Researcher : Wong RMS |
| List of Research Outputs |
| Chee W.Y.Y., Wong S.C.M., Wong R.M.S., Wong K.Y. and Lau C.T., Associated anomalies and clinical outcomes in infants with omphalocele: a single-centre 10-year review, Hong Kong Journal of Paediatrics. 2018, 23(3): 220-224. |
| Researcher : Wong RSM |
| List of Research Outputs |
| Yu Y.T.E., Chen S., Liu S.N.K., Tang H.M., Wong R.S.M., Wong C.K.H. and Lam C.L.K., Impact of Parent and Child Factors on Behavioural Problems of Children from Low-income Chinese Families, 7th Asia Pacific Primary Care Research Conference (APPCRC). 2019. |
| Yu Y.T.E., Liu S.N.K., Tang H.M., Wong R.S.M., Wong C.K.H. and Lam C.L.K., Understanding stress among low-income parents in Hong Kong, WONCA Asia Pacific Regional Conference 2019. |
| Researcher : Wong SCM |
| List of Research Outputs |
| Chee W.Y.Y., Wong S.C.M., Wong R.M.S., Wong K.Y. and Lau C.T., Associated anomalies and clinical outcomes in infants with omphalocele: a single-centre 10-year review, Hong Kong Journal of Paediatrics. 2018, 23(3): 220-224. |
| Researcher : Wong VCN |
| Project Title: | Rett Syndrome :Systematic screening of MECP2 in children with autistic traits and or unexplained mental retardation/ encephalopathy to define the spectrum of Rett Syndrome phenotypes resulting from mutations in MECP2 |
| Investigator(s): | Wong CNV |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2006 |
| Project Title: | A study of copy number variations (CNVs) of genes NRXN1, GRIN2A, GRIN2B and PCDH19 associated with synaptic function in Chinese children with infantile epileptic encephalopathies |
| Investigator(s): | Wong CNV, Kwong KY, Fung CW |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2014 |
| Researcher : Wong WHS |
| List of Research Outputs |
| Chiu T.A., Chung C.Y., Wong W.H.S., Lee S.L. and Chung B.H.Y., Healthcare burden of rare diseases in Hong Kong – adopting ORPHAcodes in ICD-10 based healthcare administrative datasets, Orphanet Journal of Rare Diseases. 2018, 13: 147. |
| Chung B.H.Y., Lam H.M., Chan C.M., Wong W.H.S. and Lee P.P.W., Monitoring learning outcome in Paediatric specialty clerkship using E-logbook, Frontiers in Medical and Health Sciences Education 2018: Learning in Alliance: Inter-professional Health Education and Practice, Bau Institute of Medical and Health Sciences Education, HKU, 18-19 Dec 2018. |
| Chung B.H.Y., Lam H.M., Chan C.M., Wong W.L., Wong W.H.S. and Lee P.P.W., Monitoring learning outcome in paediatric specialty clerkship using e-logbook, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018. 88. |
| Chung C.Y., Chiu T.A., Wong W.H.S., Lee S.L. and Chung B.H.Y., Healthcare burden of rare diseases in Hong Kong – Adopting orphacodes in ICD-10 based healthcare administrative datasets, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018.. 2018, 22. |
| Lee P.P.W., Lam H.M., Chan C.M., Wong W.L., Wong W.H.S. and Chung B.H.Y., Authentic feedback in client-based learning – patient / parent satisfaction questionnaire (PSQ) as a feedback tool in clinical competence test for paediatric specialty clerkship, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018.. 2018. |
| Lee P.P.W., Lam H.M., Chan C.M., Wong W.H.S. and Chung B.H.Y., Teaching and learning physical examination in the clinical setting: Authentic assessment of multi-domain competencies for independent professional practice, Frontiers in Medical and Health Sciences Education 2018: Learning in Alliance: Inter-professional Health Education and Practice, Bau Institute of Medical and Health Sciences Education, HKU, 18-19 Dec 2018. |
| Leung K.C., MAK C.C.Y., Fung L.F., Wong W.H.S., TSANG H.Y., YU H.C., Pei L.C.S., Yeung K.S., Mok T.K.G., Lee C.P., Hui P.W., Tang M.H.Y., Chan Y.K., Liu A.P.Y., Yang W., Sham P.C., Kan S.Y.A. and Chung B.H.Y., Identifying the genetic causes for prenatally diagnosed structural congenital anomalies (SCAs) by whole-exome sequencing (WES), BMC Medical Genomics. 2018, 11. |
| Leung K.C., Luk H.M., Tang H.M.V., Gao W., MAK C.C.Y., YU H.C., Wong W.L., Chu W.Y., Yang W., Wong W.H.S., Ma C.H., Leung A.Y.H., Jin D., Chan Y.K., Allanson J., Lo F.M.I. and Chung B.H.Y., Integrating Functional Analysis in the Next-Generation Sequencing Diagnostic Pipeline of RASopathies, Scientific Reports. 2018, 8: 2421. |
| Li W.Y.V., Liu A.P.Y., Wong W.H.S., Ho K.K., Yau J.P., Cheuk K.L.D. and Cheung Y.F., Left and right ventricular systolic and diastolic functional reserves are impaired in anthracycline-treated long-term survivors of childhood cancers, American Heart Association Scientific Sessions 2017. 2018, 136. |
| Li W.Y.V., Liu A.P.Y., Wong W.H.S., Ho K.K., Yau J.P., Cheuk K.L.D. and Cheung Y.F., Left and right ventricular systolic and diastolic functional reserves are impaired in anthracycline-treated long-term survivors of childhood cancers, J Am Soc Echocardiogr. 2019, 32: 277-285. |
| Sou Da Rosa Duque J., Cheuk K.L.D., Chong C.Y., Ip P., Wong W.H.S., Lee P.P.W., Wong I.C.K., Chan G.C.F., Lau Y.L. and Ho M.H.K., Older age and male gender as risk factors for IgE-mediated drug allergies in Chinese children, 10th Hong Kong Allergy Convention 2018. |
| WONG R.S.M., Yu Y.T.E., Wong C.K.H., TUNG T.S., Wong W.H.S., Ip P. and Lam C.L.K., Associations between physical activity and health-related quality of life, behavior and telomere length among Chinese children from low-income families in Hong Kong, International Conference and Active Living and Health. 2018. |
| Researcher : Wong WL |
| List of Research Outputs |
| Chung B.H.Y., Lam H.M., Chan C.M., Wong W.L., Wong W.H.S. and Lee P.P.W., Monitoring learning outcome in paediatric specialty clerkship using e-logbook, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018. 88. |
| Lee P.P.W., Lam H.M., Chan C.M., Wong W.L., Wong W.H.S. and Chung B.H.Y., Authentic feedback in client-based learning – patient / parent satisfaction questionnaire (PSQ) as a feedback tool in clinical competence test for paediatric specialty clerkship, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018.. 2018. |
| Leung K.C., Luk H.M., Tang H.M.V., Gao W., MAK C.C.Y., YU H.C., Wong W.L., Chu W.Y., Yang W., Wong W.H.S., Ma C.H., Leung A.Y.H., Jin D., Chan Y.K., Allanson J., Lo F.M.I. and Chung B.H.Y., Integrating Functional Analysis in the Next-Generation Sequencing Diagnostic Pipeline of RASopathies, Scientific Reports. 2018, 8: 2421. |
| Researcher : Wong WL |
| List of Research Outputs |
| Chung B.H.Y., Lam H.M., Chan C.M., Wong W.L., Wong W.H.S. and Lee P.P.W., Monitoring learning outcome in paediatric specialty clerkship using e-logbook, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018. 88. |
| Lee P.P.W., Lam H.M., Chan C.M., Wong W.L., Wong W.H.S. and Chung B.H.Y., Authentic feedback in client-based learning – patient / parent satisfaction questionnaire (PSQ) as a feedback tool in clinical competence test for paediatric specialty clerkship, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018.. 2018. |
| Leung K.C., Luk H.M., Tang H.M.V., Gao W., MAK C.C.Y., YU H.C., Wong W.L., Chu W.Y., Yang W., Wong W.H.S., Ma C.H., Leung A.Y.H., Jin D., Chan Y.K., Allanson J., Lo F.M.I. and Chung B.H.Y., Integrating Functional Analysis in the Next-Generation Sequencing Diagnostic Pipeline of RASopathies, Scientific Reports. 2018, 8: 2421. |
| Researcher : Xiang Z |
| List of Research Outputs |
| Lam K.T., Xiang Z., Liu Y., WANG X. and Tu W., Human Vγ9Vδ2-T cells exhibit potent antiviral activity against EV71 infection, Immunology 2019. |
| Researcher : YIU PTS |
| List of Research Outputs |
| YIU P.T.S., Hui K.F., Choi C.K., Kao R.Y.T., MA C.W., Yang D. and Chiang A.K.S., Intracellular Iron Chelation by a Novel Compound, C7, Reactivates Epstein–Barr Virus (EBV) Lytic Cycle via the ERK-Autophagy Axis in EBV-Positive Epithelial Cancers, Cancers. 2018, 10: 505. |
| Researcher : YU HC |
| List of Research Outputs |
| Fung L.F., TSANG H.Y., Leung K.C., Yeung K.S., MAK C.C.Y., Fung C.W., Chan H.S.S., YU H.C. and Chung B.H.Y., A significant inflation in TGM6 genetic risk casts doubt in its causation in spinocerebellar ataxia type 35, Parkinsonism & Related Disorders. 2019. |
| Fung L.F., TSANG H.Y., YU H.C. and Chung B.H.Y., TGM6 variants in Chinese population – is it disease causing?, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018. |
| Leung K.C., MAK C.C.Y., Fung L.F., Wong W.H.S., TSANG H.Y., YU H.C., Pei L.C.S., Yeung K.S., Mok T.K.G., Lee C.P., Hui P.W., Tang M.H.Y., Chan Y.K., Liu A.P.Y., Yang W., Sham P.C., Kan S.Y.A. and Chung B.H.Y., Identifying the genetic causes for prenatally diagnosed structural congenital anomalies (SCAs) by whole-exome sequencing (WES), BMC Medical Genomics. 2018, 11. |
| Leung K.C., Luk H.M., Tang H.M.V., Gao W., MAK C.C.Y., YU H.C., Wong W.L., Chu W.Y., Yang W., Wong W.H.S., Ma C.H., Leung A.Y.H., Jin D., Chan Y.K., Allanson J., Lo F.M.I. and Chung B.H.Y., Integrating Functional Analysis in the Next-Generation Sequencing Diagnostic Pipeline of RASopathies, Scientific Reports. 2018, 8: 2421. |
| TSANG H.Y., Kwong B.M.H., Pei L.C.S., Leung K.C., Yeung K.S., MAK C.C.Y., YU H.C., Fung L.F., Liang R., Chung B.H.Y. and Chan H.S.S., Application of whole exome sequencing in neuromuscular disorders patients in Hong Kong, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018. 17. |
| TSANG H.Y., Leung K.C., Ho C.C.A., Yeung K.S., MAK C.C.Y., Pei L.C.S., YU H.C., Kan S.Y.A., Chan Y.K., Kwong K.L., Lee S.L., Yung A.W.Y., Fung C.W. and Chung B.H.Y., Exome sequencing identifies molecular diagnosis in children with drug-resistant epilepsy, Epilepsia Open. 2018. |
| YU H.C., TSANG H.Y., Pei L.C.S., Chan V.C.M., Rodenburg R.J.T., Smeitink J., Lee N.N.C., Fung C.W. and Chung B.H.Y., COQ10 deficiency due to biallelic COQ4 mutations – An early onset mitochondrial disorder common in southern Chinese due to a founder mutation, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018. (Award for oral presentation - 2nd prize). 2018, 20. |
| Researcher : Yang J |
| List of Research Outputs |
| Wang Y., Zhang Y., Zhu Z., Wang T., Morris D.L., Shen J.J., Zhang H., Pan H.F., Yang J., Yang S., Ye D.Q., Vyse T.J., Cui Y., Zhang X., Sheng Y., Lau Y.L. and Yang W., Identification of ST3AGL4 , MFHAS1, CSNK2A2 and CD226 as loci associated with systemic lupus erythematosus (SLE) and evaluation of SLE genetics in drug repositioning , Annals of the Rheumatic Diseases. 2018, 77: 1078-1084. |
| ZHANG H., ZHANG Y., Wang Y., Morris D., Hirankarn N., Sheng Y., Shen J.J., Pan H.F., Yang J., Yang S., Cui Y., Ye D.Q., Vyse T.J., Zhang X., Lau Y.L. and Yang W., Meta-analysis of GWAS on both Chinese and European populations identifies GPR173 as a novel X chromosome susceptibility gene for SLE, Arthritis Research & Therapy. 2018, 20. |
| Researcher : Yang M |
| Project Title: | Protective effect of thrombopoietin on iron-induced cardiomyopathy |
| Investigator(s): | Yang M |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Children's Thalassaemia Foundation - General Awards |
| Start Date: | 07/2007 |
| Project Title: | The effect of melatonin in the treatment of thrombocytopenia |
| Investigator(s): | Yang M |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Queen Mary Hospital Charitable Trust - Training and Research Assistance Scheme |
| Start Date: | 01/2008 |
| Project Title: | The protective effects of thrombopoietin and amlodipine on iron overload-induced human mesenchymal stem cell damage: its impact on iron overload related osteopenia & osteoporosis |
| Investigator(s): | Yang M, Chan GCF, Cheung YF, Liu C |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Children's Thalassaemia Foundation - General Awards |
| Start Date: | 01/2009 |
| Researcher : Yang W |
| Project Title: | Meta-analysis of SLE GWAS followed by replication on X chromosome in cross-ethnic populations |
| Investigator(s): | Yang W, Lau YL, Yang J |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2015 |
| Project Title: | Unravelling the genetic puzzle of systemic lupus erythematosus (SLE) through comprehensive analyses of genetic association by functional annotation of genes, variants, and genomic regions |
| Investigator(s): | Yang W, Lau YL, Chung BHY, Sham PC |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2016 |
| Project Title: | Sub-phenotype analysis of systemic lupus erythematosus for novel loci with disease association and lupus nephritis predisposition |
| Investigator(s): | Yang W |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| Completion Date: | 11/2018 |
| Project Title: | Development of a genetic testing method by next generation sequencing for Thalassaemia - a pilot study |
| Investigator(s): | Yang W, Ha SY, So JCC, Ip HW, Yang J |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Children's Thalassaemia Foundation - General Awards |
| Start Date: | 06/2017 |
| Project Title: | Computational analysis of transcription factor allele-specific binding to identify susceptibility genes and elucidate their mechanistic role in systemic lupus erythematosus |
| Investigator(s): | Yang W |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2018 |
| Project Title: | American society of human genetics (ASHG) annual meeting 2018; In-depth analysis of differential DNA methylation reveals novel disease genes and pathways in SLE |
| Investigator(s): | Yang W |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2018 |
| Completion Date: | 10/2018 |
| Project Title: | Functional characterization of TACI, a newly discovered susceptibility gene for SLE in Asians |
| Investigator(s): | Yang W |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2019 |
| List of Research Outputs |
| Chan T.F., Hui K.F., Yang W., Shen J.J., Lam K.P., Kwok H., Sham P.C., Tsao G.S.W., Kwong D.L.W., Lung M.L. and Chiang A.K.S., Genome-wide analysis identifies high-risk Epstein-Barr virus associated with nasopharyngeal carcinoma., HKU Research Postgraduate Seminar, December 5-7, 2018.. 2018. |
| Chen R., Lau Y.L. and Yang W., Detecting Small Inversions Using SRinversion, Methods in Molecular Biology. Humana Press, 2018, 107-114. |
| Huang F., Chen W., Peng J., Li Y., Zhuang Y., Zhu Z., Shao C., Yang W., Yao H. and Zhang S., LncRNA PVT1 triggers Cyto-protective autophagy and promotes pancreatic ductal adenocarcinoma development via the miR-20a-5p/ULK1 Axis, Molecular Cancer. 2018, 17. |
| Hui K.F., CHAN T.F., Yang W., Shen J.J., Lam K.P., Kwok H.I.N., Sham P.C., Tsao G.S.W., Kwong D.L.W., Lung M.L. and Chiang A.K.S., High risk Epstein‐Barr virus variants characterized by distinct polymorphisms in the EBER locus are strongly associated with nasopharyngeal carcinoma, International Journal of Cancer. 2019, 144: 3031-3042. |
| KWOK S.Y.J., Guo M., Yang W., Ip P., LEE C.K., Lu L., Chan G.C.F., Middleton D. and van der Zanden H.G.M., Simulation of non-inherited maternal antigens acceptable HLA mismatches to increase the chance of matched cord blood units: Hong Kong’s experience, Human Immunology. 2018, 79: 539-544. |
| Leung K.C., MAK C.C.Y., Fung L.F., Wong W.H.S., TSANG H.Y., YU H.C., Pei L.C.S., Yeung K.S., Mok T.K.G., Lee C.P., Hui P.W., Tang M.H.Y., Chan Y.K., Liu A.P.Y., Yang W., Sham P.C., Kan S.Y.A. and Chung B.H.Y., Identifying the genetic causes for prenatally diagnosed structural congenital anomalies (SCAs) by whole-exome sequencing (WES), BMC Medical Genomics. 2018, 11. |
| Leung K.C., Luk H.M., Tang H.M.V., Gao W., MAK C.C.Y., YU H.C., Wong W.L., Chu W.Y., Yang W., Wong W.H.S., Ma C.H., Leung A.Y.H., Jin D., Chan Y.K., Allanson J., Lo F.M.I. and Chung B.H.Y., Integrating Functional Analysis in the Next-Generation Sequencing Diagnostic Pipeline of RASopathies, Scientific Reports. 2018, 8: 2421. |
| MAK C.C.Y., Leung K.C., Mok T.K.G., Yeung K.S., Yang W., Fung C.W., Chan H.S.S., Lee S.L., Lee N.C., Pfundt R., Lau Y.L. and Chung B.H.Y., Exome sequencing for paediatric-onset diseases: impact of the extensive involvement of medical geneticists in the diagnostic odyssey, npj Genomic Medicine. 2018, 3. |
| Tang S.M., Li P., Lai P.L., Fu A., Lau C.S.T., So M.T., Lui N.C., Li Z., Zhuang X., Yu M., Liu X., Ngo N., Miao X., Zhang X., Yi B., Tang S., Sun X., Zhang F., Liu H., Liu Q., Wang H., Huang L., Dong X., Tou J., Cheah K.S.E., Yang W., Yuan Z., Yip K., Sham P.C., Tam P.K.H., Garcia-Barcelo M.M. and Ngan E.S.W., Identification of genes associated with Hirschsprung Disease, based on whole-genome sequence analysis, and potential effects on enteric nervous system development, Gastroenterology. 2018, 155(6): 1908-1922. |
| Wang B., Bao S., ZHANG Z., ZHOU X., WANG J., Fan Y., Zhang Y., Li Y., Chen L.P., Jia Y., LI J., Li M., Zheng W., Mu N., Yang W., Yu Z., Lau D.S.S., Wong S.M., ZHANG Y., Kwan J.S.K., Mak H.K.F., Ambalavanan A., Zhou S., Cai W., Zheng J., Huang S., Rouleau G.A., Yang W., Rogaeva E., Ma X., St George-Hyslop P., Chu L.W. and Song Y., A rare variant in MLKL confers susceptibility to ApoE ɛ4-negative Alzheimer's disease in Hong Kong Chinese population, Neurobiol Aging. 2018, 68:160: e1-e7. |
| Wang F., Ye Z., Deng J., Siu K.L., Gao W., Chaudhary V., Cheng Y., Fung S.Y., Yuen K.S., Ho T.H., Chan C.P., Zhang Y., Kok K.H., Yang W., Chan C.P. and Jin D., Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16. , EMBO reports. 2018. |
| Wang Y., Zhang Y., Zhu Z., Wang T., Morris D.L., Shen J.J., Zhang H., Pan H.F., Yang J., Yang S., Ye D.Q., Vyse T.J., Cui Y., Zhang X., Sheng Y., Lau Y.L. and Yang W., Identification of ST3AGL4 , MFHAS1, CSNK2A2 and CD226 as loci associated with systemic lupus erythematosus (SLE) and evaluation of SLE genetics in drug repositioning , Annals of the Rheumatic Diseases. 2018, 77: 1078-1084. |
| Wang Y., Lau Y.L. and Yang W., Genetic studies on systemic lupus erythematosus in East Asia point to population differences in disease susceptibility, American Journal of Medical Genetics Part C: Seminars in Medical Genetics. 2019. |
| Yeung K.S., Lee T.L., Mok M.Y., Mak C.C.Y., Yang W., Chong C.Y., Lee P.P.W., Ho M.H.K., Choufani S., Lau W.C.S., Lau Y.L., Weksberg R. and Chung B.H.Y., Cell Lineage-specific Genome-wide DNA Methylation Analysis of Patients with Paediatric-onset Systemic Lupus Erythematosus, Epigenetics. 2019. |
| ZHANG H., ZHANG Y., Wang Y., Morris D., Hirankarn N., Sheng Y., Shen J.J., Pan H.F., Yang J., Yang S., Cui Y., Ye D.Q., Vyse T.J., Zhang X., Lau Y.L. and Yang W., Meta-analysis of GWAS on both Chinese and European populations identifies GPR173 as a novel X chromosome susceptibility gene for SLE, Arthritis Research & Therapy. 2018, 20. |
| Researcher : Yeung KS |
| List of Research Outputs |
| Fung L.F., TSANG H.Y., Leung K.C., Yeung K.S., MAK C.C.Y., Fung C.W., Chan H.S.S., YU H.C. and Chung B.H.Y., A significant inflation in TGM6 genetic risk casts doubt in its causation in spinocerebellar ataxia type 35, Parkinsonism & Related Disorders. 2019. |
| Leung K.C., MAK C.C.Y., Fung L.F., Wong W.H.S., TSANG H.Y., YU H.C., Pei L.C.S., Yeung K.S., Mok T.K.G., Lee C.P., Hui P.W., Tang M.H.Y., Chan Y.K., Liu A.P.Y., Yang W., Sham P.C., Kan S.Y.A. and Chung B.H.Y., Identifying the genetic causes for prenatally diagnosed structural congenital anomalies (SCAs) by whole-exome sequencing (WES), BMC Medical Genomics. 2018, 11. |
| MAK C.C.Y., Leung K.C., Mok T.K.G., Yeung K.S., Yang W., Fung C.W., Chan H.S.S., Lee S.L., Lee N.C., Pfundt R., Lau Y.L. and Chung B.H.Y., Exome sequencing for paediatric-onset diseases: impact of the extensive involvement of medical geneticists in the diagnostic odyssey, npj Genomic Medicine. 2018, 3. |
| TSANG H.Y., Kwong B.M.H., Pei L.C.S., Leung K.C., Yeung K.S., MAK C.C.Y., YU H.C., Fung L.F., Liang R., Chung B.H.Y. and Chan H.S.S., Application of whole exome sequencing in neuromuscular disorders patients in Hong Kong, 2nd Joint Annual Research & Scientific Meeting 2018, HK, 28 July 2018. 17. |
| TSANG H.Y., Leung K.C., Ho C.C.A., Yeung K.S., MAK C.C.Y., Pei L.C.S., YU H.C., Kan S.Y.A., Chan Y.K., Kwong K.L., Lee S.L., Yung A.W.Y., Fung C.W. and Chung B.H.Y., Exome sequencing identifies molecular diagnosis in children with drug-resistant epilepsy, Epilepsia Open. 2018. |
| Yeung K.S., Lee T.L., Mok M.Y., Mak C.C.Y., Yang W., Chong C.Y., Lee P.P.W., Ho M.H.K., Choufani S., Lau W.C.S., Lau Y.L., Weksberg R. and Chung B.H.Y., Cell Lineage-specific Genome-wide DNA Methylation Analysis of Patients with Paediatric-onset Systemic Lupus Erythematosus, Epigenetics. 2019. |
| Yeung K.S., Ho S.P., Lee S.L., Kan S.Y.A., Chan Y.K., Tang M.H.Y., MAK C.C.Y., Leung K.C., So P.L., Pfundt R., Marshall C.R., Scherer S.W., Choufani S., Weksberg R. and Chung B.H.Y., Paternal uniparental disomy of chromosome 19 in a pair of monochorionic diamniotic twins with dysmorphic features and developmental delay, Journal of Medical Genetics. 2018, jmedgenet-2018-105328. |
| Researcher : Yick LW |
| Project Title: | Defining the roles of epidermal growth factor (EGF) in the regulation of chondrocyte differentiation and endochondral bone formation |
| Investigator(s): | Yick LW, Chan SY |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Researcher : Yung AWY |
| List of Research Outputs |
| TSANG H.Y., Leung K.C., Ho C.C.A., Yeung K.S., MAK C.C.Y., Pei L.C.S., YU H.C., Kan S.Y.A., Chan Y.K., Kwong K.L., Lee S.L., Yung A.W.Y., Fung C.W. and Chung B.H.Y., Exome sequencing identifies molecular diagnosis in children with drug-resistant epilepsy, Epilepsia Open. 2018. |
| Researcher : Yung TC |
| List of Research Outputs |
| Baruteau A.E., Kyndt F., Behr E.R., Vink A.S., Lachaud M., Joong A., Schott J.J., Horie M., Denjoy I., Crotti L., Shimizu W., Bos J.M., SStephenson E.A., Wong L., Abrams D.J., Davis A.M., Winbo A., Dubin A.M., Sanatani S., Liberman L., Kaski J.P., Rudic B., Kwok S.Y., Rieubland C., Tfelt-Hansen J., Van Hare G.F., Guyomarc'h-Delasalle B., Blom N.A., Wijeyeratne Y.D., Gourraud J.D., Le Marec H., Ozawa J., Fressart V., Lupoglazoff J.M., Dagradi F., Spazzolini C., Aiba T., Tester D.J., Zahavich L.A., Beausejour-Ladouceur V., Jadhav M., Skinner J.R., Franciosi S., Krahn A.D., Abdelsayed M., Ruben P.C., Yung T.C., Ackerman M.J., Wilde A.A., Schwartz P.J. and Probst V., SCN5A mutations in 442 neonates and children: genotype–phenotype correlation and identification of higher-risk subgroups, European Heart Journal. 2018, 39: 2879-2887. |
| Kwok S.Y., Liu A.P.Y., Chan C.Y.Y., Lun K.S., Fung L.F., MAK C.C.Y., Chung B.H.Y. and Yung T.C., Clinical and genetic profile of congenital long QT syndrome in Hong Kong: a 20-year experience in paediatrics, Hong Kong Medical Journal. 2018. |
| Zayts O.A., Shipman H.E., Fung L.F., Liu A.P.Y., Kwok S.Y., Tsai A.C.H., Yung T.C. and Chung B.H.Y., The different facets of “culture” in genetic counseling: A situated analysis of genetic counseling in Hong Kong, American Journal of Medical Genetics Part C: Seminars in Medical Genetics. 2019. |
| Researcher : ZHANG H |
| List of Research Outputs |
| Wang Y., Zhang Y., Zhu Z., Wang T., Morris D.L., Shen J.J., Zhang H., Pan H.F., Yang J., Yang S., Ye D.Q., Vyse T.J., Cui Y., Zhang X., Sheng Y., Lau Y.L. and Yang W., Identification of ST3AGL4 , MFHAS1, CSNK2A2 and CD226 as loci associated with systemic lupus erythematosus (SLE) and evaluation of SLE genetics in drug repositioning , Annals of the Rheumatic Diseases. 2018, 77: 1078-1084. |
| ZHANG H., ZHANG Y., Wang Y., Morris D., Hirankarn N., Sheng Y., Shen J.J., Pan H.F., Yang J., Yang S., Cui Y., Ye D.Q., Vyse T.J., Zhang X., Lau Y.L. and Yang W., Meta-analysis of GWAS on both Chinese and European populations identifies GPR173 as a novel X chromosome susceptibility gene for SLE, Arthritis Research & Therapy. 2018, 20. |
| Researcher : Zhang H |
| List of Research Outputs |
| Wang Y., Zhang Y., Zhu Z., Wang T., Morris D.L., Shen J.J., Zhang H., Pan H.F., Yang J., Yang S., Ye D.Q., Vyse T.J., Cui Y., Zhang X., Sheng Y., Lau Y.L. and Yang W., Identification of ST3AGL4 , MFHAS1, CSNK2A2 and CD226 as loci associated with systemic lupus erythematosus (SLE) and evaluation of SLE genetics in drug repositioning , Annals of the Rheumatic Diseases. 2018, 77: 1078-1084. |
| ZHANG H., ZHANG Y., Wang Y., Morris D., Hirankarn N., Sheng Y., Shen J.J., Pan H.F., Yang J., Yang S., Cui Y., Ye D.Q., Vyse T.J., Zhang X., Lau Y.L. and Yang W., Meta-analysis of GWAS on both Chinese and European populations identifies GPR173 as a novel X chromosome susceptibility gene for SLE, Arthritis Research & Therapy. 2018, 20. |
| Researcher : Zhang Y |
| Project Title: | The ASHG 64th Annual Meeting; Meta-analysis on the 22q11.21 region identifies an autoimmune disease risk allele as associated with systemic lupus erythematosus |
| Investigator(s): | Zhang Y |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2014 |
| List of Research Outputs |
| Wang F., Ye Z., Deng J., Siu K.L., Gao W., Chaudhary V., Cheng Y., Fung S.Y., Yuen K.S., Ho T.H., Chan C.P., Zhang Y., Kok K.H., Yang W., Chan C.P. and Jin D., Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16. , EMBO reports. 2018. |
| Researcher : Zheng J |
| Project Title: | Gammadelta-T cell-targeted therapy on the formation of adaptive immunity against influenza virus infection |
| Investigator(s): | Zheng J, Tu W, Liu Y, Lau YL |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research for New Staff |
| Start Date: | 01/2016 |