DEPT OF MICROBIOLOGY



Researcher : AW YONG KL

List of Research Outputs

Lau S.K.P., ZHAO S., Sridhar S., Yip C.Y., AW YONG K.L., Chow E.Y.Y., Cheung K.C.M., Hui R.W.H., Leung R.Y.H., Lai S.K., Wu A.K.L., To K.K.W., Woo P.C.Y. and Yuen K.Y., Molecular epidemiology of coxsackievirus A6 circulating in Hong Kong reveals common neurological manifestations and emergence of novel recombinant groups, Journal of Clinical Virology. 2018, 108: 43-49.


Researcher : Ahmed SS

List of Research Outputs

Lau S.K.P., Wong Y.M., Tsang C.C., Ahmed S.S., Au Yeung K.H.R., Yuen K.Y., Wernery U. and Woo P.C.Y., Discovery and sequence analysis of four deltacoronaviruses from birds in the Middle East reveal interspecies jumping with recombination as a potential mechanism for avian-to-avian and avian-to-mammalian transmission, Journal of Virology. 2018, 92: e00265-18.


Researcher : CHAN KF

List of Research Outputs

Tsang C.C., TANG Y.M., CHAN K.F., Lee C.Y., Chan J.F.W., Ngan A.H.Y., Cheung M., Lau E.C.L., Li X., Ng R.H.Y., Lai C.K.C., Fung S.C.K., Lau S.K.P. and Woo P.C.Y., Diversity of phenotypically non-dermatophyte, non-Aspergillus filamentous fungi causing nail infections: importance of accurate identification and antifungal susceptibility testing, Emerging Microbes & Infections. 2019, 8: 531-541.
Wernery U., Tsang C.C., Hebel C., Damerau A., Kinne J., Cai J., Küspert H., Chan K.F., Joseph M., XUE S., Raghavan R., Tang Y.M.J., Syriac G., Lau S.K.P., Jose S. and Woo P.C.Y., Serodiagnosis of aspergillosis in falcons (Falco spp.) by an Afmp1p-based enzyme-linked immunosorbent assay, Mycoses. Blackwell Verlag GmbH, 2018, 61: 600-609.


Researcher : CHEN P

List of Research Outputs

Wang P., Song W., Mok B.W.Y., Zheng M., Lau S.Y.P., Liu S., CHEN P., Huang X., LIU H., CREMIN C.J. and Chen H., The PB2 Polymerase Host Adaptation Substitutions Prime Avian Indonesia Sub Clade 2.1 H5N1 Viruses for Infecting Humans, Viruses. Switerland, MDPI, 2019, 11: 292.


Researcher : CHEN SMY

List of Research Outputs

LIU W., Wong Y.C., CHEN S.M.Y., TANG J., Wang H., Cheung K.L.A. and Chen Z., DNA prime/MVTT boost regimen with HIV-1 mosaic Gag enhances the potency of antigen-specific immune responses, Vaccine. 2018, 36: 4621-4632.


Researcher : CHIK KKH

List of Research Outputs

Chan J.F.W., Yuan S., CHIK K.K.H., Yip C.Y., Tee K.M., Lai K.K., Kao R.Y.T. and Yuen K.Y., Repurposing novobiocin as a flavivirus protease inhibitor, 67th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2018). 2018.
Chan J.F.W., TSANG O.L., ZOU Z., CHIK K.K.H., Yuan S., Chu H., Lau S.K.P. and Yuen K.Y., The Cellular Kinase Inhibitor OSU-03012 Inhibits Enterovirus 71 In Vitro, Annual Meeting of the Infectious Diseases Society of America, IDWeek 2018.
Yuan S., Chan J.F.W., Ye Z.W., Wen L., Tsang T.G.W., Cao J., Huang J., Chan C.Y.C., Chik K.K.H., Choi G.K.Y., Cai J., Yin F., Chu H., Liang M., Jin D. and Yuen K.Y., Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus, Viruses. 2019, 11: 385.
ZHU Z., Chu H., WEN L., Yuan S., CHIK K.K.H., YUEN T.T., Yip C.Y., WANG D., Zhou J., Yin F., Jin D., Kok K.H., Yuen K.Y. and Chan J.F.W., Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy, International Journal of Molecular Sciences. 2019, 20: 392.


Researcher : CREMIN CJ

List of Research Outputs

Wang P., Song W., Mok B.W.Y., Zheng M., Lau S.Y.P., Liu S., CHEN P., Huang X., LIU H., CREMIN C.J. and Chen H., The PB2 Polymerase Host Adaptation Substitutions Prime Avian Indonesia Sub Clade 2.1 H5N1 Viruses for Infecting Humans, Viruses. Switerland, MDPI, 2019, 11: 292.


Researcher : Cai J

List of Research Outputs

Guo Q., Chan J.F.W., Poon K.M., Wu S., Chan C.S., Hou L., Yip C.Y., Ren C., Cai J., Zhao M., Zhang J., Song X., Chan K.H., Wang B., Kok K.H., Wen Y., Yuen K.Y. and Chen W., Immunization With a Novel Human Type 5 Adenovirus-Vectored Vaccine Expressing the Premembrane and Envelope Proteins of Zika Virus Provides Consistent and Sterilizing Protection in Multiple Immunocompetent and Immunocompromised Animal Models, The Journal of Infectious Diseases. 2018, 218: 365-377.
Lau S.K.P., Wong A.C.P., Zhang L., Luk H.K.H., Kwok J.S.L., Ahmed S.S., Cai J., Zhao P.S.H., Teng L.L., Tsui S.K.W., Yuen K.Y. and Woo P.C.Y., Novel Bat Alphacoronaviruses in Southern China Support Chinese Horseshoe Bats as an Important Reservoir for Potential Novel Coronaviruses, Viruses. 2019, 11: 423.
Sridhar S., Cheng C.C.V., Wong S.C., Yip C.Y., Wu S., Lo A.W.I., Leung K.H., Mak W.N., Cai J., Li X., Chan J.F.W., Lau S.K.P., Woo P.C.Y., Lai W.M., Kwan T.H., Au T.W.K., Lo C.M., Wong C.Y.S. and Yuen K.Y., Donor-Derived Genotype 4 Hepatitis E Virus Infection, Hong Kong, China, 2018, Emerging Infectious Diseases. 2019, 25: 425-433.
Sridhar S., Yip C.Y., Wu S., Cai J., Zhang J., Leung K.H., Chung T.W.H., Chan J.F.W., Chan W.M., Teng L.L., Au-Yeung R.K.H., Cheng C.C.V., Chen H., Lau S.K.P., Woo P.C.Y., Xia N.S., Lo C.M. and Yuen K.Y., Rat Hepatitis E Virus as Cause of Persistent Hepatitis after Liver Transplant, Emerging Infectious Diseases. 2018, 24: 2241-2250.
Wernery U., Tsang C.C., Hebel C., Damerau A., Kinne J., Cai J., Küspert H., Chan K.F., Joseph M., XUE S., Raghavan R., Tang Y.M.J., Syriac G., Lau S.K.P., Jose S. and Woo P.C.Y., Serodiagnosis of aspergillosis in falcons (Falco spp.) by an Afmp1p-based enzyme-linked immunosorbent assay, Mycoses. Blackwell Verlag GmbH, 2018, 61: 600-609.
Yeung M.L., JIA L., Yip C.Y., Chan J.F.W., Teng L.L., Chan K.H., Cai J., ZHANG C., Zhang J., Wong L.W.M., Kok K.H., Lau S.K.P., Woo P.C.Y., Lo J.Y.C., Jin D., Shih S.R. and Yuen K.Y., Human tryptophanyl-tRNA synthetase is an IFN-γ–inducible entry factor for Enterovirus, Journal of Clinical Investigation. 2018, 128: 5163-5177.
Yuan S., Chan J.F.W., Ye Z.W., Wen L., Tsang T.G.W., Cao J., Huang J., Chan C.Y.C., Chik K.K.H., Choi G.K.Y., Cai J., Yin F., Chu H., Liang M., Jin D. and Yuen K.Y., Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus, Viruses. 2019, 11: 385.


Researcher : Cao H

Project Title:Copenhagen Bioscience Conference 15 - Averting the post-antibiotic era; Transmission Of Antibiotic Resistance Genes Between Human And Swine
Investigator(s):Cao H
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2018
Completion Date:11/2018


List of Research Outputs

Cao H., XIA T., LI Y., XU Z., Bougouffa S., Lo Y., Bajic V.B., Luo H., Woo P.C.Y. and Yan A., A multidrug resistant clinical P. aeruginosa isolate in the MLST550 clonal complex: uncoupled quorum sensing modulates the interplay of virulence and resistance , Antimicrobial Agents and Chemotherapy. 2019, 63: e01944-18.
Cao H., Wong C.Y.S., Yam W.C., LIU C., Chow K.H., Wu K.L.A. and Ho P.L., Genomic investigation of a sequence type 67 Clostridium difficile causing community-acquired fulminant colitis in Hong Kong, International Journal of Medical Microbiology. 2019.
Cheng C.C.V., Wong S.C., Cao H., Chen J.H.K., So S.Y.C., Wong S.C.Y., Sridhar S., Yuen K.Y. and Ho P.L., Whole-genome sequencing data-based modeling for the investigation of an outbreak of community-associated methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit in Hong Kong, European Journal of Clinical Microbiology & Infectious Diseases. 2019, 38: 563-573.


Researcher : Cao J

List of Research Outputs

Yuan S., Chan J.F.W., Ye Z.W., Wen L., Tsang T.G.W., Cao J., Huang J., Chan C.Y.C., Chik K.K.H., Choi G.K.Y., Cai J., Yin F., Chu H., Liang M., Jin D. and Yuen K.Y., Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus, Viruses. 2019, 11: 385.


Researcher : Chan CM

List of Research Outputs

Chu H., Chan C.M., Zhang X., Wang Y., Yuan S., Zhou J., Au Yeung K.H.R., Sze K.H., Yang D., Shuai H.V., Hou Y., Li C., Zhao X., Poon K.M., Leung A.S.P., Yeung M.L., Yan J., Lu G., Jin D., Gao G.F., Chan J.F.W. and Yuen K.Y., Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells, Journal of Biological Chemistry. 2018, 293: 11709-11726.


Researcher : Chan CS

List of Research Outputs

Guo Q., Chan J.F.W., Poon K.M., Wu S., Chan C.S., Hou L., Yip C.Y., Ren C., Cai J., Zhao M., Zhang J., Song X., Chan K.H., Wang B., Kok K.H., Wen Y., Yuen K.Y. and Chen W., Immunization With a Novel Human Type 5 Adenovirus-Vectored Vaccine Expressing the Premembrane and Envelope Proteins of Zika Virus Provides Consistent and Sterilizing Protection in Multiple Immunocompetent and Immunocompromised Animal Models, The Journal of Infectious Diseases. 2018, 218: 365-377.


Researcher : Chan CYC

List of Research Outputs

Yuan S., Chan J.F.W., Ye Z.W., Wen L., Tsang T.G.W., Cao J., Huang J., Chan C.Y.C., Chik K.K.H., Choi G.K.Y., Cai J., Yin F., Chu H., Liang M., Jin D. and Yuen K.Y., Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus, Viruses. 2019, 11: 385.


Researcher : Chan E

List of Research Outputs

Chan E., Wu K.L.A., Tse C.W.S., Lau S.K.P. and Woo P.C.Y., In vitro susceptibility of ceftolozane-tazobactam against Salmonella enterica Serovar Typhi., Journal of Antimicrobial Chemotherapy. 2018, 74: 528-530.


Researcher : Chan JFW

Project Title:Efficacy and mechanistic evaluation of banana lectin (BanLec) as a novel pan-coronavirus antiviral agent: in-vitro and ex-vivo evidence
Investigator(s):Chan JFW, Yeung ML, Chan KH
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:07/2016
Completion Date:06/2019


Project Title:Commissioned Study on Conducting Tests for Zika Virus among Asymptomatic People Returning from the 2016 Olympic Games and Paralympic Games
Investigator(s):Chan JFW, Hung FNI, Yuen KY
Department:Microbiology
Source(s) of Funding:Commissioned Research on Mental Health Policy and Services
Start Date:08/2016


Project Title:Repurposing clinically approved drugs as immediately available treatment options for the emerging Zika virus infection
Investigator(s):Chan JFW, Yuan S
Department:Microbiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:04/2017
Completion Date:03/2019


Project Title:Discovery and mechanistic evaluation of novel anti-flaviviral drugs
Investigator(s):Chan JFW, Yuan S
Department:Microbiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:04/2019


List of Research Outputs

Chan J.F.W., Yuan S., Chu H., Ye Z., Wen L.R., Yan B., To K.K.W., Kao R.Y.T. and Yuen K.Y., Best Poster Award (1st place in the Young Investigator Category), The 32nd International Conference on Antiviral Research (ICAR 2019). 2019.
Chan J.F.W., Choi G.K.Y., Yip C.Y., ZHU Z., Chan K.H. and Yuen K.Y., Clinical, epidemiological, and molecular analyses of the largest dengue outbreak in Hong Kong in the last 15 years, European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 2019.
Chan J.F.W., Yuen K.Y. and Hung F.N.I., Commissioned study on conducting tests for Zika virus among asymptomatic people returning from the 2016 Olympic Games and Paralympic Games, Health Research Symposium 2019.
Chan J.F.W., Yuan S., Chu H., Ye Z., WEN L., Yan B., To K.K.W., Kao R.Y.T. and Yuen K.Y., Identification of Sterol Regulatory Element Binding Protein-Dependent Lipidomic Reprogramming as a Broad-Spectrum Antiviral Target, 32nd International Conference on Antiviral Research (ICAR). 2019.
Chan J.F.W., Yuan S., CHIK K.K.H., Yip C.Y., Tee K.M., Lai K.K., Kao R.Y.T. and Yuen K.Y., Repurposing novobiocin as a flavivirus protease inhibitor, 67th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2018). 2018.
Chan J.F.W., Chu H., YUEN T.T., Yuan S., ZHU Z. and Yuen K.Y., Targeting the endoplasmic reticulum stress signaling pathways as treatment options for Zika virus infection, 35th ASM Clinical Virology Symposium. 2019.
Chan J.F.W., TSANG O.L., ZOU Z., CHIK K.K.H., Yuan S., Chu H., Lau S.K.P. and Yuen K.Y., The Cellular Kinase Inhibitor OSU-03012 Inhibits Enterovirus 71 In Vitro, Annual Meeting of the Infectious Diseases Society of America, IDWeek 2018.
Chan J.F.W., The Most Promising Young Researcher Award, Food and Health Bureau, HKSAR Government. 2019.
Chan J.F.W., Top 1% scholar (2018), Clarivate Analytics (Thomson Reuters) Essential Science Indicators. 2018.
Chu H., Chan C.M., Zhang X., Wang Y., Yuan S., Zhou J., Au Yeung K.H.R., Sze K.H., Yang D., Shuai H.V., Hou Y., Li C., Zhao X., Poon K.M., Leung A.S.P., Yeung M.L., Yan J., Lu G., Jin D., Gao G.F., Chan J.F.W. and Yuen K.Y., Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells, Journal of Biological Chemistry. 2018, 293: 11709-11726.
Guo Q., Chan J.F.W., Poon K.M., Wu S., Chan C.S., Hou L., Yip C.Y., Ren C., Cai J., Zhao M., Zhang J., Song X., Chan K.H., Wang B., Kok K.H., Wen Y., Yuen K.Y. and Chen W., Immunization With a Novel Human Type 5 Adenovirus-Vectored Vaccine Expressing the Premembrane and Envelope Proteins of Zika Virus Provides Consistent and Sterilizing Protection in Multiple Immunocompetent and Immunocompromised Animal Models, The Journal of Infectious Diseases. 2018, 218: 365-377.
Lau S.K.P., Fan R.Y.Y., Luk H.K.H., Zhu L., Fung J., Li K.S.M., Wong W.Y.M., Ahmed S.S., Chan J.F.W., Kok K.H., Chan K.H., Wernery U., Yuen K.Y. and Woo P.C.Y., Replication of MERS and SARS coronaviruses in bat cells offers insights to their ancestral origins, Emerging Microbes & Infections. 2018, 7: 1-11.
Sridhar S., Cheng C.C.V., Wong S.C., Yip C.Y., Wu S., Lo A.W.I., Leung K.H., Mak W.N., Cai J., Li X., Chan J.F.W., Lau S.K.P., Woo P.C.Y., Lai W.M., Kwan T.H., Au T.W.K., Lo C.M., Wong C.Y.S. and Yuen K.Y., Donor-Derived Genotype 4 Hepatitis E Virus Infection, Hong Kong, China, 2018, Emerging Infectious Diseases. 2019, 25: 425-433.
Sridhar S., Chung T.W.H., Chan J.F.W., Cheng C.C.V., Lau S.K.P., Yuen K.Y. and Woo P.C.Y., Emergence of Cytomegalovirus Mononucleosis Syndrome Among Young Adults in Hong Kong Linked to Falling Seroprevalence: Results of a 14-Year Seroepidemiological Study, Open Forum Infectious Diseases. 2018, 5.
Sridhar S., Yip C.Y., Wu S., Cai J., Zhang J., Leung K.H., Chung T.W.H., Chan J.F.W., Chan W.M., Teng L.L., Au-Yeung R.K.H., Cheng C.C.V., Chen H., Lau S.K.P., Woo P.C.Y., Xia N.S., Lo C.M. and Yuen K.Y., Rat Hepatitis E Virus as Cause of Persistent Hepatitis after Liver Transplant, Emerging Infectious Diseases. 2018, 24: 2241-2250.
Tsang C.C., TANG Y.M., CHAN K.F., Lee C.Y., Chan J.F.W., Ngan A.H.Y., Cheung M., Lau E.C.L., Li X., Ng R.H.Y., Lai C.K.C., Fung S.C.K., Lau S.K.P. and Woo P.C.Y., Diversity of phenotypically non-dermatophyte, non-Aspergillus filamentous fungi causing nail infections: importance of accurate identification and antifungal susceptibility testing, Emerging Microbes & Infections. 2019, 8: 531-541.
Wong S.S.Y., Yip C.Y., Sridhar S., Leung K.H., Cheng A.K.W., Fung A.M.Y., Lam H.Y., Chan K.H., Chan J.F.W., Cheng C.C.V., Tang B.S.F. and Yuen K.Y., Comparative evaluation of a laboratory-developed real-time PCR assay and RealStar® Adenovirus PCR Kit for quantitative detection of human adenovirus, Virology Journal. 2018, 15.
Yan B., Chu H., Yang D., Sze K.H., Lai P.M., Yuan S., Shuai H.V., Wang Y., Kao R.Y.T., Chan J.F.W. and Yuen K.Y., Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication, Viruses. 2019, 11: 73.
Ye Z., CHAUDHARY V., Chan J.F.W. and Jin D., Activation of interferon-γ signaling by SFTS virus NSs protein, Keystone Symposium on “Framing the Response to Emerging Virus Infections, Pokfulam, Hong Kong. 2018.
Yeung M.L., JIA L., Yip C.Y., Chan J.F.W., Teng L.L., Chan K.H., Cai J., ZHANG C., Zhang J., Wong L.W.M., Kok K.H., Lau S.K.P., Woo P.C.Y., Lo J.Y.C., Jin D., Shih S.R. and Yuen K.Y., Human tryptophanyl-tRNA synthetase is an IFN-γ–inducible entry factor for Enterovirus, Journal of Clinical Investigation. 2018, 128: 5163-5177.
Yuan S., Chan J.F.W., Ye Z.W., Wen L., Tsang T.G.W., Cao J., Huang J., Chan C.Y.C., Chik K.K.H., Choi G.K.Y., Cai J., Yin F., Chu H., Liang M., Jin D. and Yuen K.Y., Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus, Viruses. 2019, 11: 385.
ZHU Z., Chu H., WEN L., Yuan S., CHIK K.K.H., YUEN T.T., Yip C.Y., WANG D., Zhou J., Yin F., Jin D., Kok K.H., Yuen K.Y. and Chan J.F.W., Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy, International Journal of Molecular Sciences. 2019, 20: 392.
Zhao Y., Tsang C.C., Xiao M., Chan J.F.W., Lau S.K.P., Kong F., Xu Y. and Woo P.C.Y., Yeast identification by sequencing, biochemical kits, MALDI–TOF MS and rep-PCR DNA fingerprinting, Yeast identification by sequencing, biochemical kits, MALDI–TOF MS and rep-PCR DNA fingerprinting. 2018, 56: 816–827.
Zhou P.S.H., Yip C.Y., Sridhar S., Chow W.N., To K.K.W., Chan K.H., Chan J.F.W., Cheng C.C.V., Yuen K.Y., Woo P.C.Y. and Lau S.K.P., Identification And Characteristics Of The Newly Emerged Subclades Of Enterovirus D68 Associated With Severe Respiratory/central Nervous System Infections In Hong Kong. Australia Society For Microbiology Annual Scientific Meeting 2018, (Brisbane, Australia). 2018.


Researcher : Chan KF

List of Research Outputs

Tsang C.C., TANG Y.M., CHAN K.F., Lee C.Y., Chan J.F.W., Ngan A.H.Y., Cheung M., Lau E.C.L., Li X., Ng R.H.Y., Lai C.K.C., Fung S.C.K., Lau S.K.P. and Woo P.C.Y., Diversity of phenotypically non-dermatophyte, non-Aspergillus filamentous fungi causing nail infections: importance of accurate identification and antifungal susceptibility testing, Emerging Microbes & Infections. 2019, 8: 531-541.
Wernery U., Tsang C.C., Hebel C., Damerau A., Kinne J., Cai J., Küspert H., Chan K.F., Joseph M., XUE S., Raghavan R., Tang Y.M.J., Syriac G., Lau S.K.P., Jose S. and Woo P.C.Y., Serodiagnosis of aspergillosis in falcons (Falco spp.) by an Afmp1p-based enzyme-linked immunosorbent assay, Mycoses. Blackwell Verlag GmbH, 2018, 61: 600-609.


Researcher : Chan KH

List of Research Outputs

Chan J.F.W., Choi G.K.Y., Yip C.Y., ZHU Z., Chan K.H. and Yuen K.Y., Clinical, epidemiological, and molecular analyses of the largest dengue outbreak in Hong Kong in the last 15 years, European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 2019.
Cowling B.J., Chan K.H. and Peiris J.S.M., Influenza-like illness and viral aetiology in Hong Kong children., Hong Kong Medical Journal. 2018, 24 Suppl 6(5): 12-15.
Guo Q., Chan J.F.W., Poon K.M., Wu S., Chan C.S., Hou L., Yip C.Y., Ren C., Cai J., Zhao M., Zhang J., Song X., Chan K.H., Wang B., Kok K.H., Wen Y., Yuen K.Y. and Chen W., Immunization With a Novel Human Type 5 Adenovirus-Vectored Vaccine Expressing the Premembrane and Envelope Proteins of Zika Virus Provides Consistent and Sterilizing Protection in Multiple Immunocompetent and Immunocompromised Animal Models, The Journal of Infectious Diseases. 2018, 218: 365-377.
Lau S.K.P., Fan R.Y.Y., Luk H.K.H., Zhu L., Fung J., Li K.S.M., Wong W.Y.M., Ahmed S.S., Chan J.F.W., Kok K.H., Chan K.H., Wernery U., Yuen K.Y. and Woo P.C.Y., Replication of MERS and SARS coronaviruses in bat cells offers insights to their ancestral origins, Emerging Microbes & Infections. 2018, 7: 1-11.
Leung N.H.L., Chan K.H., Chu K.W., Shiu E.Y.C., Hau B.J.P., Mcdevitt J.J., Yen H., Li Y., Ip D.K.M., Leung G.M., Peiris J.S.M., Seto W.H., Milton D.K. and Cowling B.J., Best Abstract in Category 'Infection Control', 17th Asia-Pacific Congress of Clinical Microbiology and Infection cum 8th International Infection Control Conference, Hong Kong Society for Microbiology and Infection Hong Kong Infection Control Nurses’ Association. 2018.
Leung N.H.L., Chan K.H., Chu K.W., SHIU E.Y.C., Hau J.P.B., Mcdevitt J.J., Yen H., Li Y., Ip D.K.M., Leung G.M., Peiris J.S.M., Seto W.H., Milton D.K. and Cowling B.J., Shedding and efficacy of face masks in reducing release of respiratory viruses in human exhaled breath, 17th Asia-Pacific Congress of Clinical Microbiology and Infection cum 8th International Infection Control Conference. 2018.
Liu L., Wei Q., Lin Q., Fang J., Wang H., Kwok H.Y., Tang H.Y., Nishiura K., Peng J., Wu T., Wu T., Cheung K.W., Chan K.H., Alvarez X., Qin C., Lackner A., Perlman S., Yuen K.Y. and Chen Z., Anti–spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection, JCI Insight. 2019, 4.
Lui W.Y., Yuen C.K., Li C., Wong W.M., Lui P.Y., Lin C.H., Chan K.H., Zhao H., Chen H., To K.K.W., Zhang J., Yuen K.Y. and Kok K.H., SMRT sequencing revealed the diversity and characteristics of defective interfering RNAs in influenza A (H7N9) virus infection, Emerging Microbes & Infections. 2019, 8: 662-674.
To K.K.W., Chan K.H., Ho J., Pang P.K.P., Ho D.T.Y., Chang A.C.H., Seng C.W., Yip C.C.Y., Cheng C.C.V., Hung F.N.I. and Yuen K.Y., Respiratory virus infection among hospitalized adult patients with or without clinically apparent respiratory infection: a prospective cohort study, Clinical Microbiology and Infection. 2019.
Wong S.S.Y., Yip C.Y., Sridhar S., Leung K.H., Cheng A.K.W., Fung A.M.Y., Lam H.Y., Chan K.H., Chan J.F.W., Cheng C.C.V., Tang B.S.F. and Yuen K.Y., Comparative evaluation of a laboratory-developed real-time PCR assay and RealStar® Adenovirus PCR Kit for quantitative detection of human adenovirus, Virology Journal. 2018, 15.
Yeung M.L., JIA L., Yip C.Y., Chan J.F.W., Teng L.L., Chan K.H., Cai J., ZHANG C., Zhang J., Wong L.W.M., Kok K.H., Lau S.K.P., Woo P.C.Y., Lo J.Y.C., Jin D., Shih S.R. and Yuen K.Y., Human tryptophanyl-tRNA synthetase is an IFN-γ–inducible entry factor for Enterovirus, Journal of Clinical Investigation. 2018, 128: 5163-5177.
Zhou P.S.H., Yip C.Y., Sridhar S., Chow W.N., To K.K.W., Chan K.H., Chan J.F.W., Cheng C.C.V., Yuen K.Y., Woo P.C.Y. and Lau S.K.P., Identification And Characteristics Of The Newly Emerged Subclades Of Enterovirus D68 Associated With Severe Respiratory/central Nervous System Infections In Hong Kong. Australia Society For Microbiology Annual Scientific Meeting 2018, (Brisbane, Australia). 2018.
Zhu H., Lee C.Y., Li C., Mak W.N., Chen Y., Chan K.H., Zhang J., Fung W.F., Zhang R.Q., Fung Y.F., Poon W.S.R., Lam J.Y., Tam S., Hung F.N.I., Chen H., Yuen K.Y. and To K.K.W., Low population serum microneutralization antibody titer against the predominating influenza A(H3N2) N121K virus during the severe influenza summer peak of Hong Kong in 2017, Emerging Microbes & Infections. New York, NPG, 2018, 7: 23.


Researcher : Chan WM

List of Research Outputs

Sridhar S., Yip C.Y., Wu S., Cai J., Zhang J., Leung K.H., Chung T.W.H., Chan J.F.W., Chan W.M., Teng L.L., Au-Yeung R.K.H., Cheng C.C.V., Chen H., Lau S.K.P., Woo P.C.Y., Xia N.S., Lo C.M. and Yuen K.Y., Rat Hepatitis E Virus as Cause of Persistent Hepatitis after Liver Transplant, Emerging Infectious Diseases. 2018, 24: 2241-2250.


Researcher : Chen H

Project Title:Modification of cells for isolation and characterization of SARS CoV from animal sources
Investigator(s):Chen H
Department:Microbiology
Source(s) of Funding:Seed Funding for New Staff
Start Date:07/2004


Project Title:Biological function/relevance for the 29 nucleotides insertion in the genome of animal SARS like CoV
Investigator(s):Chen H, Guan Y
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:11/2004


Project Title:Antiviral drug resistance in H5N1 virus
Investigator(s):Chen H, Guan Y
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:01/2007


Project Title:The role of RAP55 and P-bodies in the regulation of influenza virus replication
Investigator(s):Chen H
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2014


Project Title:Study on regulation of expression of EBV BARTs and function of BART LncRNAs in nasopharyngeal carcinoma cells
Investigator(s):Chen H
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2017


Project Title:Functional characterization of Epstein-Barr virus long non-coding RNAs (lnc-BARTs) in nasopharyngeal carcinoma
Investigator(s):Chen H, Dai W
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2019


List of Research Outputs

CHEUNG P.H.H., Fung S.Y., Yuen K.Y., Chen H. and Jin D., Influenza A virus PB1-F2 protein suppresses IL-1β production from human macrophages by enhancing MAVS degradation, The American Society for Virology 37th Annual Meeting, University of Maryland, College Park, Maryland, USA, July 14-18, 2018.. 2018.
Chan C.P., Yuen C.K.J., CHEUNG P.H.H., Fung S.Y., Lui P.Y., Chen H., Kok K.H. and Jin D., Antiviral activity of double-stranded RNA–binding protein PACT against influenza A virus mediated via suppression of viral RNA polymerase, The FASEB Journal. 2018, 32: 4380-4393.
Guo X., Li T., Li F., Xu Y., Wang H., Cheng W., Tang J., Zhou G., Chen H., Ng M., Ji M., Ge S. and Xia N., Intermittent abortive reactivation of Epstein-Barr virus during the progression of nasopharyngeal cancer as indicated by elevated antibody levels, Oral Oncology. England, Oxford ; New York : Pergamon, c1997, 2019, 93: 85-90.
LIU J., Mok B.W.Y., Verhoeven R.J.A. and Chen H., Study of lnc-BARTs-KDM1B epigenetic modulatory complex in maintaining Epstein-Barr Virus latency in NPC cells, 2019 Cancer Genetics and Epigenetics, April 7 - 12, 2019, Renaissance Tuscany II Ciocco in Lucca (Barga) Italy.. 2019.
Lin C., Zong J., Lin W., Wang M., Xu Y., Zhou R., Lin S., Guo Q., Chen H., Ye Y., Zhang B. and Pan J., EBV-miR-BART8-3p induces epithelial-mesenchymal transition and promotes metastasis of nasopharyngeal carcinoma cells through activating NF-κB and Erk1/2 pathways, Journal of Experimental & Clinical Cancer Research. England, APSIT, 2018, 37: 283.
Lin W., Yip Y.L., Jia L.J., Deng W., Zheng H., Dai W., Ko J.M.Y., Lo K.W., Chung G.T.Y., Yip K.Y., Lee S.D., Kwan J.S.H., Zhang J., Liu T.F., Chan Y.W., Kwong D.L.W., Lee V.H.F., Nicholls J.M., Busson P., Liu X.F., Chiang A.K.S., Hui K.F., Kwok H., Cheung S.T., Cheung Y.C., Chan C.K., Li B., Cheung A., Hau P.M., Zhou Y., Tsang C.M., Middeldorp J., Chen H., Lung M.L. and Tsao G.S.W., Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma, Nature Communications. 2018, 7; 9(1): 4663.
Lui W.Y., Yuen C.K., Li C., Wong W.M., Lui P.Y., Lin C.H., Chan K.H., Zhao H., Chen H., To K.K.W., Zhang J., Yuen K.Y. and Kok K.H., SMRT sequencing revealed the diversity and characteristics of defective interfering RNAs in influenza A (H7N9) virus infection, Emerging Microbes & Infections. 2019, 8: 662-674.
Mok B.W.Y., LIU H., Lau S.Y.P., Yuen K.Y. and Chen H., New role of the Influenza NS1 protein: Induction of miR-146a-5p for virus replication through epigenetic mechanism, Chromatin and Epigenetics EMBO WORKSHOP, 1 - 4 May, 2019, Heidelberg, Germany. 2019.
Shen C., Zhang M., Chen Y., Zhang L., Wang G., Chen J., Chen S., Li Z., Wei F., Chen J., Yang K., Guo S., Wang Y., Zheng Q., Yu H., Luo W., Zhang J., Chen H., Chen Y. and Xia N., An IgM antibody targeting the receptor binding site of influenza B blocks viral infection with great breadth and potency, Theranostics. Australia, Ivyspring International Publisher, 2019, 9: 210-231.
Sridhar S., Yip C.Y., Wu S., Cai J., Zhang J., Leung K.H., Chung T.W.H., Chan J.F.W., Chan W.M., Teng L.L., Au-Yeung R.K.H., Cheng C.C.V., Chen H., Lau S.K.P., Woo P.C.Y., Xia N.S., Lo C.M. and Yuen K.Y., Rat Hepatitis E Virus as Cause of Persistent Hepatitis after Liver Transplant, Emerging Infectious Diseases. 2018, 24: 2241-2250.
Wang P., Song W., Mok B.W.Y., Zheng M., Lau S.Y.P., Liu S., CHEN P., Huang X., LIU H., CREMIN C.J. and Chen H., The PB2 Polymerase Host Adaptation Substitutions Prime Avian Indonesia Sub Clade 2.1 H5N1 Viruses for Infecting Humans, Viruses. Switerland, MDPI, 2019, 11: 292.
Wen L.R., Chu H., Wong H.Y.B., Wang D., Li C., Zhao X., Chiu M.C., Yuan S., Fan Y., Chen H., Zhou J. and Yuen K.Y., Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses, Emerging Microbes & Infections. New York, USA, NPG, 2018, 7.
Wu H., Sun N., Song W., Zhu L., Chen H. and Cai Z., Identification of different hemagglutinin isoforms of influenza A virus H1N1, Rapid Communications in Mass Spectrometry. Chichester, John Wiley And Sons Ltd, 2018, 32: 1372-1378.
Xu Y.J., Zhou R., Zong J.F., Lin W.S., TONG S., Guo Q.J., Lin C., Lin S.J., Chen Y.X., Chen M.R., Chen H., Ye Y.B. and Pan J.J., Epstein-Barr virus-coded miR-BART13 promotes nasopharyngeal carcinoma cell growth and metastasis via targeting of the NKIRAS2/NF-κB pathway, Cancer Letters. Iceland, Amsterdam, Elsevier/North-Holland, 2019, 447: 33-40.
Zhu H., Lee C.Y., Li C., Mak W.N., Chen Y., Chan K.H., Zhang J., Fung W.F., Zhang R.Q., Fung Y.F., Poon W.S.R., Lam J.Y., Tam S., Hung F.N.I., Chen H., Yuen K.Y. and To K.K.W., Low population serum microneutralization antibody titer against the predominating influenza A(H3N2) N121K virus during the severe influenza summer peak of Hong Kong in 2017, Emerging Microbes & Infections. New York, NPG, 2018, 7: 23.


Researcher : Chen HKJ

Project Title:Molecular epidemiology study of HIV-1 among the men who have sex with men (MSM) population in Hong Kong
Investigator(s):Chen HKJ, Yam WC
Department:Microbiology
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:04/2009


List of Research Outputs

Cheng C.C.V., Wong S.C., Chen H.K.J., Wong C.Y.S. and Yuen K.Y., Mycobacterium chimaera -contaminated heater–cooler devices: the inner surface as the missing link?, Journal of Hospital Infection. 2018.
Cheng C.C.V., Wong S.C., Wong C.Y.S., Sridhar S., Yip C.Y., Chen H.K.J., Fung J., Chiu H.Y.K., Ho P.L., Chen S., Cheng B.W.C., Ho C.L., Lo C.M. and Yuen K.Y., Nosocomial transmission of hepatitis C virus in a liver transplant center in Hong Kong: implication of reusable blood collection tube holder as the vehicle for transmission, Infection Control & Hospital Epidemiology. 2018, 39: 1170-1177.
Cheng C.C.V., Wong S.C., Wong C.Y.S., Sridhar S., Yip C.Y., Chen H.K.J., Fung J., Chiu H.Y.K., Ho P.L., Chen S., Cheng B.W.C., Ho S.L., Lo C.M. and Yuen K.Y., Reusable blood collection tube holders are implicated in nosocomial hepatitis C virus transmission, Infection Control & Hospital Epidemiology. 2019, 40: 252-253.
Lau S.K.P., Xing F., Tsang C.C., TANG Y.M., TAN Y.P., Ye H., Lau R.W.T., Chen H.K.J., Lo S.K.F. and Woo P.C.Y., Clinical characteristics, rapid identification, molecular epidemiology and antifungal susceptibilities of Talaromyces marneffei infections in Shenzhen, China, Mycoses. 2019, 62: 450-457.
Teng L.L., Tang Y., Wong S.S.Y., Fong Y.H., Zhao Z.H.E., Wong C.P., Chen H.K.J., Ngan A.K.L., Wu K.L.A., Fung S.C.K., Que T.L., Lau S.K.P. and Woo P.C.Y., Maldi-tof Ms For Identification Of Tsukamurella Species: Tsukamurella Tyrosinosolvens As The Predominant Species Associated With Ocular Infections, Emerging Microbes & Infections. 2018, 7.
Tsang C.C., TANG Y.M., FONG Y.H., Kinne J., LEE H.H., Joseph M., Jose S., Schuster R.K., Tang Y., Sivakumar S., Chen H.K.J., Teng L.L., Lau S.K.P., Wernery U. and Woo P.C.Y., Ignatzschineria cameli sp. nov., isolated from necrotic foot tissue of dromedaries (Camelus dromedarius) and associated maggots (Wohlfahrtia species) in Dubai, International Journal of Systematic and Evolutionary Microbiology. 2018, 68: 3627-3634.
Wong C.Y.S., Poon W.S.R., Foo C.H., Ngan A.H.Y., Tse H., Lam C.M.V., Leung H.Y., Wong C.P., Cheng C.C.V., Chen H.K.J. and Yuen K.Y., Novel selective medium for the isolation of corynebacterium kroppenstedtii from heavily colonised clinical specimens , Journal of Clinical Pathology. 2018, 71: 781-786.


Researcher : Chen JHK

Project Title:Molecular epidemiology study of HIV-1 among the men who have sex with men (MSM) population in Hong Kong
Investigator(s):Chen HKJ, Yam WC
Department:Microbiology
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:04/2009


List of Research Outputs



Researcher : Chen M

Project Title:Immunogenicity and Cross-Protective Effect of Novel human T cell Epitopes in H5N1 influenza virus nucleoprotein
Investigator(s):Chen M, Zheng B
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:10/2010




Researcher : Chen Y

List of Research Outputs

Lee C.Y., Zhang J., Chu H., Li C., Zhu H., Mak W.W.N., Chen Y., Kok K.H., To K.K.W. and Yuen K.Y., H7N9 influenza A virus activation of necroptosis in human monocytes links innate and adaptive immune responses, Cell Death & Disease. 2019, 10.
Zhang J., ZHU H., Chen Y., LI C., Li C., Gozali L., Lee C.Y., To K.K.W., Hung F.N.I. and Yuen K.Y., Prostaglandin E2-mediated impairment of innate immune response to A(H1N1)pdm09 infection in diet-induced obese mice could be restored by paracetamol , Journal of Infectious Diseases. 2018.
Zhu H., Lee C.Y., Li C., Mak W.N., Chen Y., Chan K.H., Zhang J., Fung W.F., Zhang R.Q., Fung Y.F., Poon W.S.R., Lam J.Y., Tam S., Hung F.N.I., Chen H., Yuen K.Y. and To K.K.W., Low population serum microneutralization antibody titer against the predominating influenza A(H3N2) N121K virus during the severe influenza summer peak of Hong Kong in 2017, Emerging Microbes & Infections. New York, NPG, 2018, 7: 23.


Researcher : Chen Z

Project Title:A novel model for the study of lung pathogenesis of SARS
Investigator(s):Chen Z
Department:LKS Medical Faculty
Source(s) of Funding:National Institutes of Health, US Department of Health and Human Services - General Award
Start Date:08/2007


Project Title:Understanding the Ongoing HIV Epidemic in Yunnan China
Investigator(s):Chen Z
Department:LKS Medical Faculty
Source(s) of Funding:China AIDS Initiative - General Award
Start Date:05/2008


Project Title:Preventing HIV-1 infection using a novel vaccine immunogen
Investigator(s):Chen Z
Department:LKS Medical Faculty
Source(s) of Funding:Global Health Grants
Start Date:10/2008


Project Title:Establishment of a rapid, high-throughput, cost-effective HIV-1 drug resistance testing system
Investigator(s):Chen Z
Department:Microbiology
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:05/2011


Project Title:A Novel Vaccine for Mesothelioma Immunotherapy and Prevention;
Investigator(s):Chen Z
Department:Microbiology
Source(s) of Funding:Pneumoconiosis Compensation Fund Board - General Award
Start Date:07/2011


Project Title:AIDS Vaccine 2011 A Novel Vaccine Design for Inducing Robust HIV-1 Specific Immunity
Investigator(s):Chen Z
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:09/2011


Project Title:Blocking HIV infection by gene-encoding neutralizing antibodies
Investigator(s):Chen Z, Liu L
Department:Microbiology
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2012


Project Title:AIDS Vaccine 2012; Mucosal Prime with a Replicating Vaccinia-based Vaccine Promotes Mucosal Immunity against SIV.
Investigator(s):Chen Z
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:09/2012


Project Title:To Establish a Novel and Rapid Phenotypic HIV-1 Drug Resistance Testing System
Investigator(s):Chen Z, Liu L, Cheung KW, Du DY
Department:Microbiology
Source(s) of Funding:Guangdong-Hong Kong Technology Cooperation Funding Scheme
Start Date:07/2013


Project Title:To Establish a Novel and Rapid Phenotypic HIV-1 Drug Resistance Testing System
Investigator(s):Chen Z, Liu L, Cheung KW, Du DY
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:12/2013


Project Title:Mechanism of potentiating HIV antigen-specific CD8+ T cells
Investigator(s):Chen Z, Liu L, Yam WC, Cheung KLA, Cheung KW
Department:Microbiology
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2014


Project Title:A New Therapeutic Vaccine for HIV/AIDS
Investigator(s):Chen Z, Cheung KW
Department:Microbiology
Source(s) of Funding:Innovation and Technology Support Programme (Tier 3)
Start Date:12/2014


Project Title:A New Therapeutic Vaccine for HIV/AIDS
Investigator(s):Chen Z, Cheung KW
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2015


Project Title:A novel PDI DNA-based vaccination strategy to mimic Gag-specific responses found in HIV Elite controllers
Investigator(s):Chen Z
Department:Microbiology
Source(s) of Funding:ANR / RGC Joint Research Scheme
Start Date:04/2015


Project Title:Role of Δ42PD1 in HIV Infection
Investigator(s):Chen Z, Cheung KLA
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2015


Project Title:Induction of Mesothelioma-Specific CD8+ T Cell Response for Immunotherapy and Prevention
Investigator(s):Chen Z, Man K
Department:Microbiology
Source(s) of Funding:Pneumoconiosis Compensation Fund Board - General Award
Start Date:09/2015


Project Title:Role of PD1-Based Vaccine-Elicited CD8+ T Lymphocytes in Modulating MDSC-associated Immunosuppression
Investigator(s):Chen Z, Cheung KLA, Tan Z
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2016
Completion Date:12/2019


Project Title:A Therapeutic Bi-Specific Neutralizing Antibody for HIV/AIDS
Investigator(s):Chen Z
Department:Microbiology
Source(s) of Funding:Seed Fund for Translational and Applied Research
Start Date:01/2017


Project Title:Study on AIDS Vaccine and Immunotherapy
Investigator(s):Chen Z
Department:Microbiology
Source(s) of Funding:醫療衛生三名工程
Start Date:01/2017


Project Title:Structure-based vaccine design against HIV-1
Investigator(s):Chen Z
Department:Microbiology
Source(s) of Funding:Foundation for the National Institutes of Health (FNIH)
Start Date:04/2017


Project Title:Induction of Mesothelioma-Specific CD8+ T Cell Response for Immunotherapy and Prevention
Investigator(s):Chen Z, Man K
Department:Microbiology
Source(s) of Funding:Pneumoconiosis Compensation Fund Board - General Award
Start Date:05/2017


Project Title:Novel human neutralizing antibodies against HIV/AIDS
Investigator(s):Chen Z, Yuen KY
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:08/2017


Project Title:A Novel Therapeutic AAV-vectored Bi-Specific Neutralizing Antibody against HIV/AIDS
Investigator(s):Chen Z, Tan Z
Department:Microbiology
Source(s) of Funding:Innovation and Technology Support Programme (Tier 3)
Start Date:01/2018


Project Title:A Novel PD1-based Vaccine for HIV/AIDS Immunotherapy
Investigator(s):Chen Z
Department:Microbiology
Source(s) of Funding:Matching Grant for Joint Research
Start Date:03/2018


Project Title:Potentiating host immunity for HIV-1 functional cure (TRS)
Investigator(s):Chen Z
Department:Microbiology
Source(s) of Funding:Seed Funding for Strategic Interdisciplinary Research Scheme
Start Date:04/2018


Project Title:The role of a novel PD-1 isoform in regulating tumour-specific CD8+ T cell functions in hepatocellular carcinoma patients
Investigator(s):Chen Z
Department:Microbiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:04/2018
Completion Date:03/2019


Project Title:Humanized Mouse Models for Infection and Cancer Research
Investigator(s):Chen Z, Man K, Tsao GSW
Department:Microbiology
Source(s) of Funding:Platform Technology Funding
Start Date:06/2018


Project Title:Enhancing immunotherapeutic efficacy of mesothelioma by overcoming MDSC-mediated immunosuppression
Investigator(s):Chen Z
Department:Microbiology
Source(s) of Funding:Pneumoconiosis Compensation Fund Board - General Award
Start Date:09/2018


Project Title:A Novel Therapeutic AAV-vectored Bi-Specific Neutralizing Antibody against HIV/AIDS
Investigator(s):Chen Z, Tan Z
Department:Microbiology
Source(s) of Funding:Postdoctoral Hub Programme for ITF projects
Start Date:12/2018


Project Title:Potentiating Host Immunity for HIV-1 Functional Cure
Investigator(s):Chen Z, Song Y, Kok KH, Chu H, Liu L, Tan Z, Wong YC
Department:Microbiology
Source(s) of Funding:Theme-based Research Scheme
Start Date:01/2019


Project Title:Role of Δ42PD-1 in Human Dendritic Cells during HIV-1 Infection
Investigator(s):Chen Z, Wong YC
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2019


Project Title:A Novel PD1-based Vaccine for HIV/AIDS Immunotherapy
Investigator(s):Chen Z
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:01/2019


Project Title:Deciphering Enhancer Regulation of Tumor Immune Evasion to Develop New Combination Immunotherapies
Investigator(s):Chen Z
Department:Microbiology
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:02/2019


Project Title:Mechanism Underlying Host Immunity for Protection Against Infectious Diseases
Investigator(s):Chen Z, Yuen KY, Chen H, Chan JFW, Kok KH, Liu L
Department:Microbiology
Source(s) of Funding:Small Equipment Grant
Start Date:04/2019


Project Title:Development of a patient-derived xenograft humanized mouse model to study immunotherapy against hepatocellular carcinoma
Investigator(s):Chen Z
Department:Microbiology
Source(s) of Funding:Seed Fund for Translational and Applied Research
Start Date:06/2019


List of Research Outputs

Chen Z., 愛滋病免疫治癒研究, 5th AIDS Forum of Beijing, Hong Kong and Macau and Taiwan. 2019.
Chen Z., A tandem bispecific neutralizing antibody for HIV-1 prevention and cure, 2018 World Life Science Conference. 2018.
Chen Z., AIDS Vaccine and Cure Research, The New Horizons in HIV/AIDS Prevention and Care. 2018.
Chen Z., Anti Δ42PD 1 immunotherapy inhibits human hepatocellular carcinoma by PD 1 independent mechanisms, Microbiome Meets Immunooncology in Gastrointestinal Cancers: Basic and Translational Perspectives. 2019.
Chen Z., Engineered Tandem Bispecific Neutralising Antibody for HIV-1 Prevention and Immunotherapy, HIV Research for Prevention 2018 (HIVR4P 2018). 2018.
Chen Z., Functional Cure of HIV-1 Infection, AIDS and Vaccine. 2018.
Chen Z., Humanized NSG mouse models for HIV/AIDS, 2018 International Symposium of Humanized Mouse Models. 2018.
Chen Z., Monkey Models and HIV Vaccine Research, In: Linqi Zhang and Sharon R. Lewin, HIV Vaccines and Cure. 《HIV疫苗与治疗》, Springer Nature Singapore Pte Ltd., Springer Nature, 2018, Monkey Models and HIV Vaccine Research: 97-124.
Chen Z., Novel Approaches in Functional Cure and Prevention of HIV/AIDS, Medical and Paediatric Infectious Disease Course 2019 - Specific infectious diseases related knowledge. 2019.
Chen Z., PD1-based Vaccine Potentiates Host Immunity for HIV-1 Functional Cure, The 1st Baodi Forum: Medical Innovations in Health and Disease. 2018.
Chen Z., Potentiating Host Immunity for HIV-1 Functional Cure, 第七屆海峽兩岸四地免疫學論壇, 2018.
Chen Z., Liu L., Chen G., Cheung K.W., Du D.Y., Yao X., Lu Y., Chen L., Lin X. and Chen Z., Surging HIV-1 CRF07_BC epidemic among recently infected men who have sex with men in Fujian, China, Journal of Medical Virology. 2018, 90: 1210-1221.
Chen Z., Targeting monocyte-intrinsic enhancer reprogramming improves immunotherapy efficacy in hepatocellular carcinoma, Gut. 2019, gutjnl-2018-317257.
Chen Z., 艾滋病抗体治疗, 第二届“中国学者应对艾滋病难题大挑战”研讨会, 2018.
LING L. and Chen Z., AAV-Vectored Fms-Related Tyrosine Kinase 3 Ligand Inhibits CD34+ Progenitor Cell Engraftment in Humanized Mice, Journal of Neuroimmune Pharmacology. 2018, 13: 541-550.
LING L., Wu T., To K.K.W., Cheung K.W., Lui K.O., NIU M., LAM K.S., Wang C.C., Li J., Wang H., Yuen K.Y. and Chen Z., Vedolizumab-mediated integrin α4β7 blockade does not control HIV-1SF162 rebound after combination antiretroviral therapy interruption in humanized mice, AIDS. 2019, 33: F1-F12.
LIU W., Wong Y.C., CHEN S.M.Y., TANG J., Wang H., Cheung K.L.A. and Chen Z., DNA prime/MVTT boost regimen with HIV-1 mosaic Gag enhances the potency of antigen-specific immune responses, Vaccine. 2018, 36: 4621-4632.
Liu L., Wei Q., Lin Q., Fang J., Wang H., Kwok H.Y., Tang H.Y., Nishiura K., Peng J., Wu T., Wu T., Cheung K.W., Chan K.H., Alvarez X., Qin C., Lackner A., Perlman S., Yuen K.Y. and Chen Z., Anti–spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection, JCI Insight. 2019, 4.
Liu L., Liang J., Lu X. and Chen Z., Daidzein and its analogs reactivate HIV replication from latently infected CD4 T cells, Immunology 2019.
PANG L., Ng K.T.P., Liu J., Liu H., Liu L., Chen Z. and Man K., ILTS Travel Award - Plasmacytoid dendritic cells promote hepatocellular carcinoma recurrence after liver transplantation, ILTS 25th Annual International Congress, May 2019, Toronto, Canada. 2019.
PANG L., Ng K.T.P., Liu J., Liu H., Liu L., Chen Z. and Man K., Plasmacytoid dendritic cells promote hepatocellular carcinoma recurrence after liver transplantation, International Liver Transplant Society 25th Annual Congress, Toronto, Canada, 15-18 May 2019.
TANG J., Tan Z. and Chen Z., In vivo electroporation of a codon-optimized BERopt DNA vaccine protects mice from pathogenic Mycobacterium tuberculosis aerosol challenge, Tuberculosis. 2018, 113: 65-75.
Tan Z., Liu L., Chiu M.S., Cheung K.W., Yan C.W., Yu Z., LEE B.K., LIU W., Man K. and Chen Z., Virotherapy-recruited PMN-MDSC infiltration of mesothelioma blocks antitumor CTL by IL-10-mediated dendritic cell suppression, OncoImmunology. 2019, 8: e1518672.


Researcher : Cheng CCV

List of Research Outputs

Cheng C.C.V., Wong S.C., Wong C.Y.S., Ho P.L. and Yuen K.Y., Control of Carbapenemase-producing Enterobacteriaceae: Beyond the Hospital, EClinicalMedicine. 2018, 6: 3-4.
Cheng C.C.V., Wong S.C., Wong S.C.Y. and Yuen K.Y., Directly observed hand hygiene – from healthcare workers to patients, Journal of Hospital Infection. 2019, 101: 380-382.
Cheng C.C.V., Wong S.C., Chen H.K.J., Wong C.Y.S. and Yuen K.Y., Mycobacterium chimaera -contaminated heater–cooler devices: the inner surface as the missing link?, Journal of Hospital Infection. 2018.
Cheng C.C.V., Wong S.C., Wong C.Y.S., Sridhar S., Yip C.Y., Chen H.K.J., Fung J., Chiu H.Y.K., Ho P.L., Chen S., Cheng B.W.C., Ho C.L., Lo C.M. and Yuen K.Y., Nosocomial transmission of hepatitis C virus in a liver transplant center in Hong Kong: implication of reusable blood collection tube holder as the vehicle for transmission, Infection Control & Hospital Epidemiology. 2018, 39: 1170-1177.
Cheng C.C.V., Wong S.C., Wong C.Y.S., Sridhar S., Yip C.Y., Chen H.K.J., Fung J., Chiu H.Y.K., Ho P.L., Chen S., Cheng B.W.C., Ho S.L., Lo C.M. and Yuen K.Y., Reusable blood collection tube holders are implicated in nosocomial hepatitis C virus transmission, Infection Control & Hospital Epidemiology. 2019, 40: 252-253.
Cheng C.C.V., Wong S.C., Cao H., Chen J.H.K., So S.Y.C., Wong S.C.Y., Sridhar S., Yuen K.Y. and Ho P.L., Whole-genome sequencing data-based modeling for the investigation of an outbreak of community-associated methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit in Hong Kong, European Journal of Clinical Microbiology & Infectious Diseases. 2019, 38: 563-573.
Co T.H.M., Cheng C.C.V., Wei J., Wong C.Y.S., Chan S.M.S., Shek T.W.H. and Kwong A., Idiopathic granulomatous mastitis: a 10-year study from a multicentre clinical database, Pathology. 2018, 50: 742-747.
Lui S.L., Yap Y.H.D., Cheng C.C.V., Chan D.T.M. and Yuen K.Y., Clinical practice guidelines for the provision of renal service in Hong Kong: Infection Control in Renal Service, Nephrology. 2019, 24 Suppl 1: 98-129.
Sridhar S., Cheng C.C.V., Wong S.C., Yip C.Y., Wu S., Lo A.W.I., Leung K.H., Mak W.N., Cai J., Li X., Chan J.F.W., Lau S.K.P., Woo P.C.Y., Lai W.M., Kwan T.H., Au T.W.K., Lo C.M., Wong C.Y.S. and Yuen K.Y., Donor-Derived Genotype 4 Hepatitis E Virus Infection, Hong Kong, China, 2018, Emerging Infectious Diseases. 2019, 25: 425-433.
Sridhar S., Chung T.W.H., Chan J.F.W., Cheng C.C.V., Lau S.K.P., Yuen K.Y. and Woo P.C.Y., Emergence of Cytomegalovirus Mononucleosis Syndrome Among Young Adults in Hong Kong Linked to Falling Seroprevalence: Results of a 14-Year Seroepidemiological Study, Open Forum Infectious Diseases. 2018, 5.
Sridhar S., Yip C.Y., Wu S., Cai J., Zhang J., Leung K.H., Chung T.W.H., Chan J.F.W., Chan W.M., Teng L.L., Au-Yeung R.K.H., Cheng C.C.V., Chen H., Lau S.K.P., Woo P.C.Y., Xia N.S., Lo C.M. and Yuen K.Y., Rat Hepatitis E Virus as Cause of Persistent Hepatitis after Liver Transplant, Emerging Infectious Diseases. 2018, 24: 2241-2250.
To K.K.W., Chan K.H., Ho J., Pang P.K.P., Ho D.T.Y., Chang A.C.H., Seng C.W., Yip C.C.Y., Cheng C.C.V., Hung F.N.I. and Yuen K.Y., Respiratory virus infection among hospitalized adult patients with or without clinically apparent respiratory infection: a prospective cohort study, Clinical Microbiology and Infection. 2019.
Wang Y.L., TONG M.K., Chow K.H., Cheng C.C.V., TSE C.W., Wu K.L.A., LAI R.W., Luk W.K., Tsang D.N.C. and Ho P.L., Occurrence of Highly Conjugative IncX3 Epidemic Plasmid Carrying blaNDM in Enterobacteriaceae Isolates in Geographically Widespread Areas, Frontiers in Microbiology. 2018, 9.
Wong C.Y.S., Poon W.S.R., Foo C.H., Ngan A.H.Y., Tse H., Lam C.M.V., Leung H.Y., Wong C.P., Cheng C.C.V., Chen H.K.J. and Yuen K.Y., Novel selective medium for the isolation of corynebacterium kroppenstedtii from heavily colonised clinical specimens , Journal of Clinical Pathology. 2018, 71: 781-786.
Wong S.S.Y., Yip C.Y., Sridhar S., Leung K.H., Cheng A.K.W., Fung A.M.Y., Lam H.Y., Chan K.H., Chan J.F.W., Cheng C.C.V., Tang B.S.F. and Yuen K.Y., Comparative evaluation of a laboratory-developed real-time PCR assay and RealStar® Adenovirus PCR Kit for quantitative detection of human adenovirus, Virology Journal. 2018, 15.
Zhou P.S.H., Yip C.Y., Sridhar S., Chow W.N., To K.K.W., Chan K.H., Chan J.F.W., Cheng C.C.V., Yuen K.Y., Woo P.C.Y. and Lau S.K.P., Identification And Characteristics Of The Newly Emerged Subclades Of Enterovirus D68 Associated With Severe Respiratory/central Nervous System Infections In Hong Kong. Australia Society For Microbiology Annual Scientific Meeting 2018, (Brisbane, Australia). 2018.


Researcher : Cheung KLA

Project Title:Characterising the role of a novel PD1 isoform expressed on gamma-delta T cells in HIV-1 infection
Investigator(s):Cheung KLA, Chen Z
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:06/2016


List of Research Outputs

LIU W., Wong Y.C., CHEN S.M.Y., TANG J., Wang H., Cheung K.L.A. and Chen Z., DNA prime/MVTT boost regimen with HIV-1 mosaic Gag enhances the potency of antigen-specific immune responses, Vaccine. 2018, 36: 4621-4632.


Researcher : Cheung KW

List of Research Outputs

Chen Z., Liu L., Chen G., Cheung K.W., Du D.Y., Yao X., Lu Y., Chen L., Lin X. and Chen Z., Surging HIV-1 CRF07_BC epidemic among recently infected men who have sex with men in Fujian, China, Journal of Medical Virology. 2018, 90: 1210-1221.
LING L., Wu T., To K.K.W., Cheung K.W., Lui K.O., NIU M., LAM K.S., Wang C.C., Li J., Wang H., Yuen K.Y. and Chen Z., Vedolizumab-mediated integrin α4β7 blockade does not control HIV-1SF162 rebound after combination antiretroviral therapy interruption in humanized mice, AIDS. 2019, 33: F1-F12.
Liu L., Wei Q., Lin Q., Fang J., Wang H., Kwok H.Y., Tang H.Y., Nishiura K., Peng J., Wu T., Wu T., Cheung K.W., Chan K.H., Alvarez X., Qin C., Lackner A., Perlman S., Yuen K.Y. and Chen Z., Anti–spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection, JCI Insight. 2019, 4.
Tan Z., Liu L., Chiu M.S., Cheung K.W., Yan C.W., Yu Z., LEE B.K., LIU W., Man K. and Chen Z., Virotherapy-recruited PMN-MDSC infiltration of mesothelioma blocks antitumor CTL by IL-10-mediated dendritic cell suppression, OncoImmunology. 2019, 8: e1518672.


Researcher : Chew NFS

List of Research Outputs

Sridhar S., Wu S. and Chew N.F.S., Prevalence Of Human Hepegivirus - 1 In Hepatitis C Infected Individuals, Hong Kong , Clinical Virology Symposium . 2019.


Researcher : Chik KKH

List of Research Outputs

Chan J.F.W., Yuan S., CHIK K.K.H., Yip C.Y., Tee K.M., Lai K.K., Kao R.Y.T. and Yuen K.Y., Repurposing novobiocin as a flavivirus protease inhibitor, 67th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2018). 2018.
Chan J.F.W., TSANG O.L., ZOU Z., CHIK K.K.H., Yuan S., Chu H., Lau S.K.P. and Yuen K.Y., The Cellular Kinase Inhibitor OSU-03012 Inhibits Enterovirus 71 In Vitro, Annual Meeting of the Infectious Diseases Society of America, IDWeek 2018.
Yuan S., Chan J.F.W., Ye Z.W., Wen L., Tsang T.G.W., Cao J., Huang J., Chan C.Y.C., Chik K.K.H., Choi G.K.Y., Cai J., Yin F., Chu H., Liang M., Jin D. and Yuen K.Y., Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus, Viruses. 2019, 11: 385.
ZHU Z., Chu H., WEN L., Yuan S., CHIK K.K.H., YUEN T.T., Yip C.Y., WANG D., Zhou J., Yin F., Jin D., Kok K.H., Yuen K.Y. and Chan J.F.W., Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy, International Journal of Molecular Sciences. 2019, 20: 392.


Researcher : Chiu HYK

List of Research Outputs

Cheng C.C.V., Wong S.C., Wong C.Y.S., Sridhar S., Yip C.Y., Chen H.K.J., Fung J., Chiu H.Y.K., Ho P.L., Chen S., Cheng B.W.C., Ho C.L., Lo C.M. and Yuen K.Y., Nosocomial transmission of hepatitis C virus in a liver transplant center in Hong Kong: implication of reusable blood collection tube holder as the vehicle for transmission, Infection Control & Hospital Epidemiology. 2018, 39: 1170-1177.
Cheng C.C.V., Wong S.C., Wong C.Y.S., Sridhar S., Yip C.Y., Chen H.K.J., Fung J., Chiu H.Y.K., Ho P.L., Chen S., Cheng B.W.C., Ho S.L., Lo C.M. and Yuen K.Y., Reusable blood collection tube holders are implicated in nosocomial hepatitis C virus transmission, Infection Control & Hospital Epidemiology. 2019, 40: 252-253.


Researcher : Chiu MC

List of Research Outputs

Wen L.R., Chu H., Wong H.Y.B., Wang D., Li C., Zhao X., Chiu M.C., Yuan S., Fan Y., Chen H., Zhou J. and Yuen K.Y., Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses, Emerging Microbes & Infections. New York, USA, NPG, 2018, 7.
Zhang K., Li C., Luo Y.S., Wen L.R., Yuan S., Wang D., WONG H.Y.B., Zhao X., Chiu M.C., Ye Z., Sun Z., Zhao H., ZHANG X., Hu M., Yang D., Shuai H.V., Wang Y., He J., Bose M.E., Henrickson K.J., Huang J., Zheng B., Chu H. and Zhou J., Establishment of a lethal aged mouse model of human respiratory syncytial virus infection, Antiviral Research. 2019, 161: 125-133.


Researcher : Chiu MS

List of Research Outputs

Tan Z., Liu L., Chiu M.S., Cheung K.W., Yan C.W., Yu Z., LEE B.K., LIU W., Man K. and Chen Z., Virotherapy-recruited PMN-MDSC infiltration of mesothelioma blocks antitumor CTL by IL-10-mediated dendritic cell suppression, OncoImmunology. 2019, 8: e1518672.


Researcher : Chow KH

List of Research Outputs

Cao H., Wong C.Y.S., Yam W.C., LIU C., Chow K.H., Wu K.L.A. and Ho P.L., Genomic investigation of a sequence type 67 Clostridium difficile causing community-acquired fulminant colitis in Hong Kong, International Journal of Medical Microbiology. 2019.
Wang Y.L., TONG M.K., Chow K.H., Cheng C.C.V., TSE C.W., Wu K.L.A., LAI R.W., Luk W.K., Tsang D.N.C. and Ho P.L., Occurrence of Highly Conjugative IncX3 Epidemic Plasmid Carrying blaNDM in Enterobacteriaceae Isolates in Geographically Widespread Areas, Frontiers in Microbiology. 2018, 9.


Researcher : Chow WN

List of Research Outputs

Zhou P.S.H., Yip C.Y., Sridhar S., Chow W.N., To K.K.W., Chan K.H., Chan J.F.W., Cheng C.C.V., Yuen K.Y., Woo P.C.Y. and Lau S.K.P., Identification And Characteristics Of The Newly Emerged Subclades Of Enterovirus D68 Associated With Severe Respiratory/central Nervous System Infections In Hong Kong. Australia Society For Microbiology Annual Scientific Meeting 2018, (Brisbane, Australia). 2018.


Researcher : Chow WNF

List of Research Outputs

Chow W.N.F., Koutsovoulos G., Ovando-Vázquez C., Neophytou K., Bermúdez-Barrientos J.R., Laetsch D.R., Robertson E., Kumar S., Claycomb J.M., Blaxter M., Abreu-Goodger C. and Buck A.H., Secretion of an Argonaute protein by a parasitic nematode and the evolution of its siRNA guides, Nucleic Acids Research. 2019.
Driedonks T.A.P., van der Grein S.G., Ariyurek Y., Buermans H.P.J., Jekel H., Chow W.N.F., Wauben M.H.M., Buck A.H., ‘t Hoen P.A.C. and Nolte-‘t Hoen E.N.M., Immune stimuli shape the small non-coding transcriptome of extracellular vesicles released by dendritic cells, Cellular and Molecular Life Sciences. 2018, 75: 3857-3875.


Researcher : Chu H

Project Title:Investigating the role of caspase-6 in the replication of the Middle East respiratory syndrome coronavirus.
Investigator(s):Chu H, Zhou J, Chan JFW, Kok KH
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:07/2017


Project Title:Investigating the role of necroptosis in MERS-CoV pathogenesis
Investigator(s):Chu H
Department:Microbiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:05/2018
Completion Date:04/2019


Project Title:To dissect the role of PERK-mediated apoptosis in the pathogenesis of MERS-CoV
Investigator(s):Chu H
Department:Microbiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:05/2019


List of Research Outputs

Chan J.F.W., Yuan S., Chu H., Ye Z., Wen L.R., Yan B., To K.K.W., Kao R.Y.T. and Yuen K.Y., Best Poster Award (1st place in the Young Investigator Category), The 32nd International Conference on Antiviral Research (ICAR 2019). 2019.
Chan J.F.W., Yuan S., Chu H., Ye Z., WEN L., Yan B., To K.K.W., Kao R.Y.T. and Yuen K.Y., Identification of Sterol Regulatory Element Binding Protein-Dependent Lipidomic Reprogramming as a Broad-Spectrum Antiviral Target, 32nd International Conference on Antiviral Research (ICAR). 2019.
Chan J.F.W., Chu H., YUEN T.T., Yuan S., ZHU Z. and Yuen K.Y., Targeting the endoplasmic reticulum stress signaling pathways as treatment options for Zika virus infection, 35th ASM Clinical Virology Symposium. 2019.
Chan J.F.W., TSANG O.L., ZOU Z., CHIK K.K.H., Yuan S., Chu H., Lau S.K.P. and Yuen K.Y., The Cellular Kinase Inhibitor OSU-03012 Inhibits Enterovirus 71 In Vitro, Annual Meeting of the Infectious Diseases Society of America, IDWeek 2018.
Chu H., Chan C.M., Zhang X., Wang Y., Yuan S., Zhou J., Au Yeung K.H.R., Sze K.H., Yang D., Shuai H.V., Hou Y., Li C., Zhao X., Poon K.M., Leung A.S.P., Yeung M.L., Yan J., Lu G., Jin D., Gao G.F., Chan J.F.W. and Yuen K.Y., Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells, Journal of Biological Chemistry. 2018, 293: 11709-11726.
Lee C.Y., Zhang J., Chu H., Li C., Zhu H., Mak W.W.N., Chen Y., Kok K.H., To K.K.W. and Yuen K.Y., H7N9 influenza A virus activation of necroptosis in human monocytes links innate and adaptive immune responses, Cell Death & Disease. 2019, 10.
Wen L.R., Chu H., Wong H.Y.B., Wang D., Li C., Zhao X., Chiu M.C., Yuan S., Fan Y., Chen H., Zhou J. and Yuen K.Y., Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses, Emerging Microbes & Infections. New York, USA, NPG, 2018, 7.
Yan B., Chu H., Yang D., Sze K.H., Lai P.M., Yuan S., Shuai H.V., Wang Y., Kao R.Y.T., Chan J.F.W. and Yuen K.Y., Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication, Viruses. 2019, 11: 73.
Yuan S., Chan J.F.W., Ye Z.W., Wen L., Tsang T.G.W., Cao J., Huang J., Chan C.Y.C., Chik K.K.H., Choi G.K.Y., Cai J., Yin F., Chu H., Liang M., Jin D. and Yuen K.Y., Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus, Viruses. 2019, 11: 385.
ZHU Z., Chu H., WEN L., Yuan S., CHIK K.K.H., YUEN T.T., Yip C.Y., WANG D., Zhou J., Yin F., Jin D., Kok K.H., Yuen K.Y. and Chan J.F.W., Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy, International Journal of Molecular Sciences. 2019, 20: 392.
Zhang K., Li C., Luo Y.S., Wen L.R., Yuan S., Wang D., WONG H.Y.B., Zhao X., Chiu M.C., Ye Z., Sun Z., Zhao H., ZHANG X., Hu M., Yang D., Shuai H.V., Wang Y., He J., Bose M.E., Henrickson K.J., Huang J., Zheng B., Chu H. and Zhou J., Establishment of a lethal aged mouse model of human respiratory syncytial virus infection, Antiviral Research. 2019, 161: 125-133.
Zhao H., To K.K.W., Chu H., Ding Q., Zhao X., Li C., Shuai H.V., Yuan S., Zhou J., Kok K.H., Jiang S. and Yuen K.Y., Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza, Nature Communications. 2018, 9.
Zhou J., WANG D., WONG H.Y.B., Chu H. and Yuen K.Y., Identification and characterization of GLDC as host susceptibility gene to severe influenza., EMBO Molecular Medicine. 2018.


Researcher : Du DY

List of Research Outputs

Chen Z., Liu L., Chen G., Cheung K.W., Du D.Y., Yao X., Lu Y., Chen L., Lin X. and Chen Z., Surging HIV-1 CRF07_BC epidemic among recently infected men who have sex with men in Fujian, China, Journal of Medical Virology. 2018, 90: 1210-1221.


Researcher : FONG YH

List of Research Outputs

Teng L.L., Tang Y., Wong S.S.Y., Fong Y.H., Zhao Z.H.E., Wong C.P., Chen H.K.J., Ngan A.K.L., Wu K.L.A., Fung S.C.K., Que T.L., Lau S.K.P. and Woo P.C.Y., Maldi-tof Ms For Identification Of Tsukamurella Species: Tsukamurella Tyrosinosolvens As The Predominant Species Associated With Ocular Infections, Emerging Microbes & Infections. 2018, 7.
Tsang C.C., TANG Y.M., FONG Y.H., Kinne J., LEE H.H., Joseph M., Jose S., Schuster R.K., Tang Y., Sivakumar S., Chen H.K.J., Teng L.L., Lau S.K.P., Wernery U. and Woo P.C.Y., Ignatzschineria cameli sp. nov., isolated from necrotic foot tissue of dromedaries (Camelus dromedarius) and associated maggots (Wohlfahrtia species) in Dubai, International Journal of Systematic and Evolutionary Microbiology. 2018, 68: 3627-3634.


Researcher : FUNG J

List of Research Outputs

Luk K.H., Li X., FUNG J., Lau S.K.P. and Woo P.C.Y., Molecular epidemiology, evolution and phylogeny of SARS coronavirus, Infection, Genetics and Evolution. 2019, 71: 21-30.


Researcher : Fong YH

List of Research Outputs

Teng L.L., Tang Y., Wong S.S.Y., Fong Y.H., Zhao Z.H.E., Wong C.P., Chen H.K.J., Ngan A.K.L., Wu K.L.A., Fung S.C.K., Que T.L., Lau S.K.P. and Woo P.C.Y., Maldi-tof Ms For Identification Of Tsukamurella Species: Tsukamurella Tyrosinosolvens As The Predominant Species Associated With Ocular Infections, Emerging Microbes & Infections. 2018, 7.
Tsang C.C., TANG Y.M., FONG Y.H., Kinne J., LEE H.H., Joseph M., Jose S., Schuster R.K., Tang Y., Sivakumar S., Chen H.K.J., Teng L.L., Lau S.K.P., Wernery U. and Woo P.C.Y., Ignatzschineria cameli sp. nov., isolated from necrotic foot tissue of dromedaries (Camelus dromedarius) and associated maggots (Wohlfahrtia species) in Dubai, International Journal of Systematic and Evolutionary Microbiology. 2018, 68: 3627-3634.


Researcher : Fung SCK

List of Research Outputs

Teng L.L., Tang Y., Wong S.S.Y., Fong Y.H., Zhao Z.H.E., Wong C.P., Chen H.K.J., Ngan A.K.L., Wu K.L.A., Fung S.C.K., Que T.L., Lau S.K.P. and Woo P.C.Y., Maldi-tof Ms For Identification Of Tsukamurella Species: Tsukamurella Tyrosinosolvens As The Predominant Species Associated With Ocular Infections, Emerging Microbes & Infections. 2018, 7.
Tsang C.C., TANG Y.M., CHAN K.F., Lee C.Y., Chan J.F.W., Ngan A.H.Y., Cheung M., Lau E.C.L., Li X., Ng R.H.Y., Lai C.K.C., Fung S.C.K., Lau S.K.P. and Woo P.C.Y., Diversity of phenotypically non-dermatophyte, non-Aspergillus filamentous fungi causing nail infections: importance of accurate identification and antifungal susceptibility testing, Emerging Microbes & Infections. 2019, 8: 531-541.


Researcher : Fung WF

List of Research Outputs

Zhu H., Lee C.Y., Li C., Mak W.N., Chen Y., Chan K.H., Zhang J., Fung W.F., Zhang R.Q., Fung Y.F., Poon W.S.R., Lam J.Y., Tam S., Hung F.N.I., Chen H., Yuen K.Y. and To K.K.W., Low population serum microneutralization antibody titer against the predominating influenza A(H3N2) N121K virus during the severe influenza summer peak of Hong Kong in 2017, Emerging Microbes & Infections. New York, NPG, 2018, 7: 23.


Researcher : Fung YF

List of Research Outputs

Zhu H., Lee C.Y., Li C., Mak W.N., Chen Y., Chan K.H., Zhang J., Fung W.F., Zhang R.Q., Fung Y.F., Poon W.S.R., Lam J.Y., Tam S., Hung F.N.I., Chen H., Yuen K.Y. and To K.K.W., Low population serum microneutralization antibody titer against the predominating influenza A(H3N2) N121K virus during the severe influenza summer peak of Hong Kong in 2017, Emerging Microbes & Infections. New York, NPG, 2018, 7: 23.


Researcher : Gao P

Project Title:2018 World Life Science Conference; Alternative strategies to tackle antibiotics resistance
Investigator(s):Gao P
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2018
Completion Date:10/2018


List of Research Outputs

Gao P., Sun H., Davies J.U.L.I.A.N. and Kao R.Y.T., Alternative strategies to tackle antibiotics resistance, 2018 World Life Science Conference. 2018.


Researcher : Gozali L

List of Research Outputs

Zhang J., ZHU H., Chen Y., LI C., Li C., Gozali L., Lee C.Y., To K.K.W., Hung F.N.I. and Yuen K.Y., Prostaglandin E2-mediated impairment of innate immune response to A(H1N1)pdm09 infection in diet-induced obese mice could be restored by paracetamol , Journal of Infectious Diseases. 2018.


Researcher : Guan Y

Project Title:Vaccines for the control of H5N1 and other avian influenza viruses
Investigator(s):Guan Y
Department:Microbiology
Source(s) of Funding:The University of Hong Kong Foundation Seed Grant
Start Date:04/2002


Project Title:Searching for the precursor of SARS-Cov in Southern China
Investigator(s):Guan Y
Department:Microbiology
Source(s) of Funding:VCO SARS Research Fund
Start Date:07/2003


Project Title:Special Research Achievement Award 2003-2004
Investigator(s):Guan Y
Department:School of Public Health
Source(s) of Funding:Special Research Achievement Award
Start Date:11/2004


Project Title:Partner State Key Laboratory of Emerging Infectious Diseases
Investigator(s):Guan Y
Department:Microbiology
Source(s) of Funding:Matching Fund for State Key Laboratory (SKL)
Start Date:02/2009


Project Title:Research Output Prize (Li Ka Shing Faculty of Medicine)
Investigator(s):Guan Y
Department:School of Public Health
Source(s) of Funding:Research Output Prize (in Faculty)
Start Date:01/2013


Project Title:Outstanding Researcher Award 2013-14
Investigator(s):Guan Y
Department:School of Public Health
Source(s) of Funding:Outstanding Researcher Award
Start Date:12/2014


Project Title:Prevention & Research of Emerging Infectious Viral Diseases
Investigator(s):Guan Y
Department:School of Public Health
Source(s) of Funding:Ministry of Science and Technology of The People's Republic of China (MOST)
Start Date:04/2018




Researcher : Ho CC

List of Research Outputs

Chong Y.K., Ho C.C., Leung S.Y., Lau S.K.P. and Woo P.C.Y., Clinical Mass Spectrometry in the Bioinformatics Era: A Hitchhiker’s Guide, Computational and Structural Biotechnology Journal. 2018, 16: 316-334.
Chong Y.K., Ho C.C., Leung S.Y., Lau S.K.P. and Woo P.C.Y., Clinical Mass Spectrometry in the Bioinformatics Era: A Hitchhiker’s Guide, Computational and Structural Biotechnology Journal. 2018, 16: 316-334.


Researcher : Ho PL

Project Title:A phenotypic and genotypic analysis of vancomycin tolerance in Streptococcus pnemoniae
Investigator(s):Ho PL, Yuen KY, Que TL
Department:Microbiology
Source(s) of Funding:Low Budget High Impact Programme
Start Date:11/2000


Project Title:Molecular epidemiology of fluoroquinolone-resistant streptococcus pneumoniae in Hong kong and Canada
Investigator(s):Ho PL
Department:Microbiology
Source(s) of Funding:Low Budget High Impact Programme
Start Date:11/2001


Project Title:Risk factors for SARS in health care workers following incubation of SARS patients
Investigator(s):Ho PL, Hung CT
Department:Microbiology
Source(s) of Funding:VCO SARS Research Fund
Start Date:07/2003


Project Title:Fluoroquinolone susceptibility clinical breakpoints and fluoroquinolone-resistant determining mutations among clinical strains of streptococcus pneumoniae
Investigator(s):Ho PL, Wong SSY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:11/2003


Project Title:Evaluation of molecular tests for the rapid detection of rifampicin and isoniazid resistance in Mycobacterium tuberculosis and their impact on patient management
Investigator(s):Ho PL, Yam WC, Leung CC, Yew WW, Mok YWT, Chan KS, Tam CM
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:04/2006


Project Title:Syndromic Surveillance and Modeling for Infectious Diseases
Investigator(s):Ho PL, Wu JTK
Department:Microbiology
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2013


Project Title:Molecular epidemiology of transferrable multidrug-resistant pump oqxAB in Escherichia coli from human and animal sources
Investigator(s):Ho PL, Lo WU
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:06/2015


Project Title:Unveiling the characteristics of emerging Staphylococcus lugdunensis sequence type 3 clone by genomics analysis
Investigator(s):Ho PL, Sham PC, Lo WU
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2016
Completion Date:04/2019


Project Title:Surveillance of antibiotic resistance genes in Hong Kong populations using metagenomics approaches
Investigator(s):Ho PL, Cao H, Chow KH
Department:Microbiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:05/2018
Completion Date:04/2019


Project Title:Evaluation of Phenotypic Tests for Rapid Detection of Carbapenemase-producing Enterobacteriaceae
Investigator(s):Ho PL
Department:Microbiology
Source(s) of Funding:Commissioned Project: Health and Medical Research Fund
Start Date:08/2018


Project Title:Emerging of multidrug resistant Bacteroides fragilis in Hong Kong
Investigator(s):Ho PL, Cao H, Chow KH
Department:Microbiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:05/2019


List of Research Outputs

Cao H., Wong C.Y.S., Yam W.C., LIU C., Chow K.H., Wu K.L.A. and Ho P.L., Genomic investigation of a sequence type 67 Clostridium difficile causing community-acquired fulminant colitis in Hong Kong, International Journal of Medical Microbiology. 2019.
Cheng C.C.V., Wong S.C., Wong C.Y.S., Ho P.L. and Yuen K.Y., Control of Carbapenemase-producing Enterobacteriaceae: Beyond the Hospital, EClinicalMedicine. 2018, 6: 3-4.
Cheng C.C.V., Wong S.C., Wong C.Y.S., Sridhar S., Yip C.Y., Chen H.K.J., Fung J., Chiu H.Y.K., Ho P.L., Chen S., Cheng B.W.C., Ho C.L., Lo C.M. and Yuen K.Y., Nosocomial transmission of hepatitis C virus in a liver transplant center in Hong Kong: implication of reusable blood collection tube holder as the vehicle for transmission, Infection Control & Hospital Epidemiology. 2018, 39: 1170-1177.
Cheng C.C.V., Wong S.C., Wong C.Y.S., Sridhar S., Yip C.Y., Chen H.K.J., Fung J., Chiu H.Y.K., Ho P.L., Chen S., Cheng B.W.C., Ho S.L., Lo C.M. and Yuen K.Y., Reusable blood collection tube holders are implicated in nosocomial hepatitis C virus transmission, Infection Control & Hospital Epidemiology. 2019, 40: 252-253.
Cheng C.C.V., Wong S.C., Cao H., Chen J.H.K., So S.Y.C., Wong S.C.Y., Sridhar S., Yuen K.Y. and Ho P.L., Whole-genome sequencing data-based modeling for the investigation of an outbreak of community-associated methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit in Hong Kong, European Journal of Clinical Microbiology & Infectious Diseases. 2019, 38: 563-573.
Sun H., Wang R., LAI T.P., Ho P.L., Woo P.C.Y., Kao R.Y.T. and Li H., From metallomics to drug development: bismuth-based agents as inhibitors against metallo-β-lactamase , 14th European Biological Inorganic Chemistry Conference (EuroBIC-14), Birmingham, UK, August 26-30, 2018. 2018.
Sun H., WANG R., LAI T.P., Ho P.L., Woo P.C.Y., Kao R.Y.T. and Li H., From metallomics to drug development: bismuth-based agents as inhibitors against metallo-β-lactamase, 11th International BioMetals Symposium (BioMetals-2018), Ottawa, Canada, July 15-19, 2018. 2018.
Sun H., Wang R., Wang H., Hu X., Kao R.Y.T., Ho P.L. and Li H., Integrative metallomic approach to uncover metallo-proteomes in microbes: novel way to overcome antimicrobial resistance?, 15th Eurasia Conference on Chemical Sciences ((EuAsC2S-15), Rome, Italy, September 5-8, 2018. 2018.
TAM K.G.K., Leung S.S., Siu G.K.H., CHANG K.C., Wong S.S.Y., Ho P.L., Leung K.C. and Yam W.C., Direct detection of pyrazinamide resistance in Mycobacterium tuberculosis by use of pncA PCR sequencing. , Journal of Clinical Microbiology. American Society of Microbiology, 2019, 57.
Wang Y.L., TONG M.K., Chow K.H., Cheng C.C.V., TSE C.W., Wu K.L.A., LAI R.W., Luk W.K., Tsang D.N.C. and Ho P.L., Occurrence of Highly Conjugative IncX3 Epidemic Plasmid Carrying blaNDM in Enterobacteriaceae Isolates in Geographically Widespread Areas, Frontiers in Microbiology. 2018, 9.


Researcher : Hou Y

List of Research Outputs

Chu H., Chan C.M., Zhang X., Wang Y., Yuan S., Zhou J., Au Yeung K.H.R., Sze K.H., Yang D., Shuai H.V., Hou Y., Li C., Zhao X., Poon K.M., Leung A.S.P., Yeung M.L., Yan J., Lu G., Jin D., Gao G.F., Chan J.F.W. and Yuen K.Y., Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells, Journal of Biological Chemistry. 2018, 293: 11709-11726.


Researcher : Hu M

List of Research Outputs

Zhang K., Li C., Luo Y.S., Wen L.R., Yuan S., Wang D., WONG H.Y.B., Zhao X., Chiu M.C., Ye Z., Sun Z., Zhao H., ZHANG X., Hu M., Yang D., Shuai H.V., Wang Y., He J., Bose M.E., Henrickson K.J., Huang J., Zheng B., Chu H. and Zhou J., Establishment of a lethal aged mouse model of human respiratory syncytial virus infection, Antiviral Research. 2019, 161: 125-133.


Researcher : Huang J

List of Research Outputs

Yuan S., Chan J.F.W., Ye Z.W., Wen L., Tsang T.G.W., Cao J., Huang J., Chan C.Y.C., Chik K.K.H., Choi G.K.Y., Cai J., Yin F., Chu H., Liang M., Jin D. and Yuen K.Y., Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus, Viruses. 2019, 11: 385.


Researcher : Hung FNI

Project Title:Treatment of severe influenza A infection with celecoxib: a double blind randomized controlled trial
Investigator(s):Hung FNI, To KKW, Chan JFW, Chan KH, Yuen KY
Department:Medicine
Source(s) of Funding:Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential
Start Date:12/2014


Project Title:A double-blind randomized controlled trial of 13-valent pneumococcal conjugated vaccine in patients with chronic illness
Investigator(s):Hung FNI, Chan KH
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2015
Completion Date:06/2019


Project Title:Intrademal quadrivalent influenza vaccine with topical imiquimod in elderly & chronic illness subjects, a double-blind randomized controlled tria
Investigator(s):Hung FNI, Yuen KY, Cheng CCV, Chan KH
Department:Medicine
Source(s) of Funding:Commissioned Study on Influenza Vaccine with Imiquimod in Elderly and Chronic Illness Subjects
Start Date:06/2019


List of Research Outputs

Li X., BLAIS J.E., Wong I.C.K., Tam A.W., Cowling B.J., Hung F.N.I. and Chan E.W.Y., Population-based estimates of the burden of pneumonia hospitalizations in Hong Kong, 2011–2015. , Eur J Clin Microbiol Infect Dis. 2019, 38(3): 553-561.
To K.K.W., Chan K.H., Ho J., Pang P.K.P., Ho D.T.Y., Chang A.C.H., Seng C.W., Yip C.C.Y., Cheng C.C.V., Hung F.N.I. and Yuen K.Y., Respiratory virus infection among hospitalized adult patients with or without clinically apparent respiratory infection: a prospective cohort study, Clinical Microbiology and Infection. 2019.
Zhu H., Lee C.Y., Li C., Mak W.N., Chen Y., Chan K.H., Zhang J., Fung W.F., Zhang R.Q., Fung Y.F., Poon W.S.R., Lam J.Y., Tam S., Hung F.N.I., Chen H., Yuen K.Y. and To K.K.W., Low population serum microneutralization antibody titer against the predominating influenza A(H3N2) N121K virus during the severe influenza summer peak of Hong Kong in 2017, Emerging Microbes & Infections. New York, NPG, 2018, 7: 23.


Researcher : Im SWK

Project Title:Investigation of community exposure to a novel coronavirus associated with SARS and herd immunity developed among healthy blood donors
Investigator(s):Im SWK, Yam WC
Department:Microbiology
Source(s) of Funding:VCO SARS Research Fund
Start Date:07/2003




Researcher : JIA L

List of Research Outputs

Bao S., Jia L., Zhou X., ZHANG Z., Wu W.L., Yu Z., NG G.C.T., Fan Y., Wong S.M., Huang S., To K.K.W., Yuen K.Y., Yeung M.L. and Song Y., Integrated analysis of mRNA-seq and miRNA-seq for host susceptibilities to influenza A (H7N9) infection in inbred mouse lines, Functional & Integrative Genomics. 2018, 18: 411-424.
Yeung M.L., JIA L., Yip C.Y., Chan J.F.W., Teng L.L., Chan K.H., Cai J., ZHANG C., Zhang J., Wong L.W.M., Kok K.H., Lau S.K.P., Woo P.C.Y., Lo J.Y.C., Jin D., Shih S.R. and Yuen K.Y., Human tryptophanyl-tRNA synthetase is an IFN-γ–inducible entry factor for Enterovirus, Journal of Clinical Investigation. 2018, 128: 5163-5177.


Researcher : Jia L

List of Research Outputs

Bao S., Jia L., Zhou X., ZHANG Z., Wu W.L., Yu Z., NG G.C.T., Fan Y., Wong S.M., Huang S., To K.K.W., Yuen K.Y., Yeung M.L. and Song Y., Integrated analysis of mRNA-seq and miRNA-seq for host susceptibilities to influenza A (H7N9) infection in inbred mouse lines, Functional & Integrative Genomics. 2018, 18: 411-424.
Yeung M.L., JIA L., Yip C.Y., Chan J.F.W., Teng L.L., Chan K.H., Cai J., ZHANG C., Zhang J., Wong L.W.M., Kok K.H., Lau S.K.P., Woo P.C.Y., Lo J.Y.C., Jin D., Shih S.R. and Yuen K.Y., Human tryptophanyl-tRNA synthetase is an IFN-γ–inducible entry factor for Enterovirus, Journal of Clinical Investigation. 2018, 128: 5163-5177.


Researcher : Kao RYT

Project Title:Development of anti-virulence strategy by targeting the SaeS signaling system of Staphylococcus aureus
Investigator(s):Kao RYT, Gao P
Department:Microbiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:01/2017


Project Title:Structure and function study of Mp1p of pathogenic Talaromyces (Penicillium) marneffei: a novel virulence mechanism for the evasion of host defense
Investigator(s):Kao RYT, Yuen KY, Sze KH
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:07/2017


List of Research Outputs

Chan J.F.W., Yuan S., Chu H., Ye Z., Wen L.R., Yan B., To K.K.W., Kao R.Y.T. and Yuen K.Y., Best Poster Award (1st place in the Young Investigator Category), The 32nd International Conference on Antiviral Research (ICAR 2019). 2019.
Chan J.F.W., Yuan S., Chu H., Ye Z., WEN L., Yan B., To K.K.W., Kao R.Y.T. and Yuen K.Y., Identification of Sterol Regulatory Element Binding Protein-Dependent Lipidomic Reprogramming as a Broad-Spectrum Antiviral Target, 32nd International Conference on Antiviral Research (ICAR). 2019.
Chan J.F.W., Yuan S., CHIK K.K.H., Yip C.Y., Tee K.M., Lai K.K., Kao R.Y.T. and Yuen K.Y., Repurposing novobiocin as a flavivirus protease inhibitor, 67th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2018). 2018.
Gao P., Sun H., Davies J.U.L.I.A.N. and Kao R.Y.T., Alternative strategies to tackle antibiotics resistance, 2018 World Life Science Conference. 2018.
Lam W.H., Sze K.H., Ke Y., Tse M.K., Zhang H., Woo P.C.Y., Lau S.K.P., Lau C.C.Y., Xu S., Lai P.M., Zhou T., Antonyuk S.V., Kao R.Y.T., Yuen K.Y. and Hao Q., Talaromyces marneffei Mp1 Protein, a Novel Virulence Factor, Carries Two Arachidonic Acid-Binding Domains To Suppress Inflammatory Responses in Hosts , Infection and Immunity. 2019, 87.
Sun H., Wang R., LAI T.P., Ho P.L., Woo P.C.Y., Kao R.Y.T. and Li H., From metallomics to drug development: bismuth-based agents as inhibitors against metallo-β-lactamase , 14th European Biological Inorganic Chemistry Conference (EuroBIC-14), Birmingham, UK, August 26-30, 2018. 2018.
Sun H., WANG R., LAI T.P., Ho P.L., Woo P.C.Y., Kao R.Y.T. and Li H., From metallomics to drug development: bismuth-based agents as inhibitors against metallo-β-lactamase, 11th International BioMetals Symposium (BioMetals-2018), Ottawa, Canada, July 15-19, 2018. 2018.
Sun H., Wang R., Wang H., Hu X., Kao R.Y.T., Ho P.L. and Li H., Integrative metallomic approach to uncover metallo-proteomes in microbes: novel way to overcome antimicrobial resistance?, 15th Eurasia Conference on Chemical Sciences ((EuAsC2S-15), Rome, Italy, September 5-8, 2018. 2018.
WAN W., Kao R.Y.T. and Hao Q., The apo structure of Dehydrosqualene Desaturase and the co-crystal structure with inhibitors, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.
YIU P.T.S., Hui K.F., Choi C.K., Kao R.Y.T., MA C.W., Yang D. and Chiang A.K.S., Intracellular Iron Chelation by a Novel Compound, C7, Reactivates Epstein–Barr Virus (EBV) Lytic Cycle via the ERK-Autophagy Axis in EBV-Positive Epithelial Cancers, Cancers. 2018, 10: 505.
Yan B., Chu H., Yang D., Sze K.H., Lai P.M., Yuan S., Shuai H.V., Wang Y., Kao R.Y.T., Chan J.F.W. and Yuen K.Y., Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication, Viruses. 2019, 11: 73.


Researcher : Kok KH

Project Title:Identification of a novel splice isoform of TRBP and characterization of its role in microRNA biogenesis
Investigator(s):Kok KH, Wong CM
Department:School of Biomedical Sciences
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2012


Project Title:Mechanistic study of the roles of PACT in MDA5-mediated innate antiviral immunity
Investigator(s):Kok KH, Chan CP
Department:School of Biomedical Sciences
Source(s) of Funding:National Natural Science Foundation of China (NSFC) - General Program
Start Date:01/2013


Project Title:Suppression of PACT-dependent antiviral response by measles virus V protein
Investigator(s):Kok KH
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:03/2015


Project Title:A novel approach for the identification of N6-methyladenosine (m6A) RNA modification in human and viral mRNA
Investigator(s):Kok KH
Department:Microbiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:01/2017
Completion Date:12/2018


Project Title:The role of ARRDC3 in the innate immune response to influenza A virus infection
Investigator(s):Kok KH, Chen H
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2017


Project Title:Functional role of an interferon-stimulated gene IFIRM in influenza A virus infection
Investigator(s):Kok KH, Chen H
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2018


Project Title:Functional Role of Herpes Simplex Virus 2 Latency-Associated Transcript in the Survival of Human Sensory Neurons
Investigator(s):Kok KH
Department:Microbiology
Source(s) of Funding:Seed Fund for Basic Research for Resubmission of GRF/ECS Proposals
Start Date:07/2018
Completion Date:11/2018


Project Title:Modulation of type-I interferon signaling by Non-Structural proteins of Zika virus
Investigator(s):Kok KH, Chan JFW
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:09/2018


Project Title:Rational design and synthesis of an influenza A defective interfering virus for the development of an attenuated intradermal vaccine
Investigator(s):Kok KH
Department:Microbiology
Source(s) of Funding:Seed Fund for Translational and Applied Research
Start Date:01/2019


List of Research Outputs

Chan C.P., Yuen C.K.J., CHEUNG P.H.H., Fung S.Y., Lui P.Y., Chen H., Kok K.H. and Jin D., Antiviral activity of double-stranded RNA–binding protein PACT against influenza A virus mediated via suppression of viral RNA polymerase, The FASEB Journal. 2018, 32: 4380-4393.
Guo Q., Chan J.F.W., Poon K.M., Wu S., Chan C.S., Hou L., Yip C.Y., Ren C., Cai J., Zhao M., Zhang J., Song X., Chan K.H., Wang B., Kok K.H., Wen Y., Yuen K.Y. and Chen W., Immunization With a Novel Human Type 5 Adenovirus-Vectored Vaccine Expressing the Premembrane and Envelope Proteins of Zika Virus Provides Consistent and Sterilizing Protection in Multiple Immunocompetent and Immunocompromised Animal Models, The Journal of Infectious Diseases. 2018, 218: 365-377.
Lau S.K.P., Fan R.Y.Y., Luk H.K.H., Zhu L., Fung J., Li K.S.M., Wong W.Y.M., Ahmed S.S., Chan J.F.W., Kok K.H., Chan K.H., Wernery U., Yuen K.Y. and Woo P.C.Y., Replication of MERS and SARS coronaviruses in bat cells offers insights to their ancestral origins, Emerging Microbes & Infections. 2018, 7: 1-11.
Lee C.Y., Zhang J., Chu H., Li C., Zhu H., Mak W.W.N., Chen Y., Kok K.H., To K.K.W. and Yuen K.Y., H7N9 influenza A virus activation of necroptosis in human monocytes links innate and adaptive immune responses, Cell Death & Disease. 2019, 10.
Lui W.Y., Yuen C.K., Li C., Wong W.M., Lui P.Y., Lin C.H., Chan K.H., Zhao H., Chen H., To K.K.W., Zhang J., Yuen K.Y. and Kok K.H., SMRT sequencing revealed the diversity and characteristics of defective interfering RNAs in influenza A (H7N9) virus infection, Emerging Microbes & Infections. 2019, 8: 662-674.
Wang F., Ye Z., Deng J., Siu K.L., Gao W., Chaudhary V., Cheng Y., Fung S.Y., Yuen K.S., Ho T.H., Chan C.P., Zhang Y., Kok K.H., Yang W., Chan C.P. and Jin D., Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16. , EMBO reports. 2018.
Yeung M.L., JIA L., Yip C.Y., Chan J.F.W., Teng L.L., Chan K.H., Cai J., ZHANG C., Zhang J., Wong L.W.M., Kok K.H., Lau S.K.P., Woo P.C.Y., Lo J.Y.C., Jin D., Shih S.R. and Yuen K.Y., Human tryptophanyl-tRNA synthetase is an IFN-γ–inducible entry factor for Enterovirus, Journal of Clinical Investigation. 2018, 128: 5163-5177.
ZHU Z., Chu H., WEN L., Yuan S., CHIK K.K.H., YUEN T.T., Yip C.Y., WANG D., Zhou J., Yin F., Jin D., Kok K.H., Yuen K.Y. and Chan J.F.W., Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy, International Journal of Molecular Sciences. 2019, 20: 392.
Zhao H., To K.K.W., Chu H., Ding Q., Zhao X., Li C., Shuai H.V., Yuan S., Zhou J., Kok K.H., Jiang S. and Yuen K.Y., Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza, Nature Communications. 2018, 9.


Researcher : Kwok HY

List of Research Outputs

Liu L., Wei Q., Lin Q., Fang J., Wang H., Kwok H.Y., Tang H.Y., Nishiura K., Peng J., Wu T., Wu T., Cheung K.W., Chan K.H., Alvarez X., Qin C., Lackner A., Perlman S., Yuen K.Y. and Chen Z., Anti–spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection, JCI Insight. 2019, 4.


Researcher : LAM KS

List of Research Outputs

LING L., Wu T., To K.K.W., Cheung K.W., Lui K.O., NIU M., LAM K.S., Wang C.C., Li J., Wang H., Yuen K.Y. and Chen Z., Vedolizumab-mediated integrin α4β7 blockade does not control HIV-1SF162 rebound after combination antiretroviral therapy interruption in humanized mice, AIDS. 2019, 33: F1-F12.


Researcher : LEE BK

List of Research Outputs

Tan Z., Liu L., Chiu M.S., Cheung K.W., Yan C.W., Yu Z., LEE B.K., LIU W., Man K. and Chen Z., Virotherapy-recruited PMN-MDSC infiltration of mesothelioma blocks antitumor CTL by IL-10-mediated dendritic cell suppression, OncoImmunology. 2019, 8: e1518672.


Researcher : LEE HH

List of Research Outputs

Tsang C.C., TANG Y.M., FONG Y.H., Kinne J., LEE H.H., Joseph M., Jose S., Schuster R.K., Tang Y., Sivakumar S., Chen H.K.J., Teng L.L., Lau S.K.P., Wernery U. and Woo P.C.Y., Ignatzschineria cameli sp. nov., isolated from necrotic foot tissue of dromedaries (Camelus dromedarius) and associated maggots (Wohlfahrtia species) in Dubai, International Journal of Systematic and Evolutionary Microbiology. 2018, 68: 3627-3634.


Researcher : LI C

List of Research Outputs

Chu H., Chan C.M., Zhang X., Wang Y., Yuan S., Zhou J., Au Yeung K.H.R., Sze K.H., Yang D., Shuai H.V., Hou Y., Li C., Zhao X., Poon K.M., Leung A.S.P., Yeung M.L., Yan J., Lu G., Jin D., Gao G.F., Chan J.F.W. and Yuen K.Y., Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells, Journal of Biological Chemistry. 2018, 293: 11709-11726.
Lee C.Y., Zhang J., Chu H., Li C., Zhu H., Mak W.W.N., Chen Y., Kok K.H., To K.K.W. and Yuen K.Y., H7N9 influenza A virus activation of necroptosis in human monocytes links innate and adaptive immune responses, Cell Death & Disease. 2019, 10.
Li C., To K.K.W., Zhang J., Lee C.Y., Zhu H., Mak W.N., Hung F.N.I. and Yuen K.Y., Co-stimulation With TLR7 Agonist Imiquimod and Inactivated Influenza Virus Particles Promotes Mouse B Cell Activation, Differentiation, and Accelerated Antigen Specific Antibody Production., Frontiers in Immunology. 2018, 9.
Lui W.Y., Yuen C.K., Li C., Wong W.M., Lui P.Y., Lin C.H., Chan K.H., Zhao H., Chen H., To K.K.W., Zhang J., Yuen K.Y. and Kok K.H., SMRT sequencing revealed the diversity and characteristics of defective interfering RNAs in influenza A (H7N9) virus infection, Emerging Microbes & Infections. 2019, 8: 662-674.
Wen L.R., Chu H., Wong H.Y.B., Wang D., Li C., Zhao X., Chiu M.C., Yuan S., Fan Y., Chen H., Zhou J. and Yuen K.Y., Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses, Emerging Microbes & Infections. New York, USA, NPG, 2018, 7.
Zhang J., ZHU H., Chen Y., LI C., Li C., Gozali L., Lee C.Y., To K.K.W., Hung F.N.I. and Yuen K.Y., Prostaglandin E2-mediated impairment of innate immune response to A(H1N1)pdm09 infection in diet-induced obese mice could be restored by paracetamol , Journal of Infectious Diseases. 2018.
Zhang K., Li C., Luo Y.S., Wen L.R., Yuan S., Wang D., WONG H.Y.B., Zhao X., Chiu M.C., Ye Z., Sun Z., Zhao H., ZHANG X., Hu M., Yang D., Shuai H.V., Wang Y., He J., Bose M.E., Henrickson K.J., Huang J., Zheng B., Chu H. and Zhou J., Establishment of a lethal aged mouse model of human respiratory syncytial virus infection, Antiviral Research. 2019, 161: 125-133.
Zhao H., To K.K.W., Chu H., Ding Q., Zhao X., Li C., Shuai H.V., Yuan S., Zhou J., Kok K.H., Jiang S. and Yuen K.Y., Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza, Nature Communications. 2018, 9.
Zhu H., Lee C.Y., Li C., Mak W.N., Chen Y., Chan K.H., Zhang J., Fung W.F., Zhang R.Q., Fung Y.F., Poon W.S.R., Lam J.Y., Tam S., Hung F.N.I., Chen H., Yuen K.Y. and To K.K.W., Low population serum microneutralization antibody titer against the predominating influenza A(H3N2) N121K virus during the severe influenza summer peak of Hong Kong in 2017, Emerging Microbes & Infections. New York, NPG, 2018, 7: 23.


Researcher : LING L

List of Research Outputs

LING L. and Chen Z., AAV-Vectored Fms-Related Tyrosine Kinase 3 Ligand Inhibits CD34+ Progenitor Cell Engraftment in Humanized Mice, Journal of Neuroimmune Pharmacology. 2018, 13: 541-550.
LING L., Wu T., To K.K.W., Cheung K.W., Lui K.O., NIU M., LAM K.S., Wang C.C., Li J., Wang H., Yuen K.Y. and Chen Z., Vedolizumab-mediated integrin α4β7 blockade does not control HIV-1SF162 rebound after combination antiretroviral therapy interruption in humanized mice, AIDS. 2019, 33: F1-F12.


Researcher : LIU C

List of Research Outputs

Cao H., Wong C.Y.S., Yam W.C., LIU C., Chow K.H., Wu K.L.A. and Ho P.L., Genomic investigation of a sequence type 67 Clostridium difficile causing community-acquired fulminant colitis in Hong Kong, International Journal of Medical Microbiology. 2019.


Researcher : LIU H

List of Research Outputs

Mok B.W.Y., LIU H., Lau S.Y.P., Yuen K.Y. and Chen H., New role of the Influenza NS1 protein: Induction of miR-146a-5p for virus replication through epigenetic mechanism, Chromatin and Epigenetics EMBO WORKSHOP, 1 - 4 May, 2019, Heidelberg, Germany. 2019.
Wang P., Song W., Mok B.W.Y., Zheng M., Lau S.Y.P., Liu S., CHEN P., Huang X., LIU H., CREMIN C.J. and Chen H., The PB2 Polymerase Host Adaptation Substitutions Prime Avian Indonesia Sub Clade 2.1 H5N1 Viruses for Infecting Humans, Viruses. Switerland, MDPI, 2019, 11: 292.


Researcher : LIU J

List of Research Outputs

LIU J., Mok B.W.Y., Verhoeven R.J.A. and Chen H., Study of lnc-BARTs-KDM1B epigenetic modulatory complex in maintaining Epstein-Barr Virus latency in NPC cells, 2019 Cancer Genetics and Epigenetics, April 7 - 12, 2019, Renaissance Tuscany II Ciocco in Lucca (Barga) Italy.. 2019.


Researcher : LIU W

List of Research Outputs

LIU W., Wong Y.C., CHEN S.M.Y., TANG J., Wang H., Cheung K.L.A. and Chen Z., DNA prime/MVTT boost regimen with HIV-1 mosaic Gag enhances the potency of antigen-specific immune responses, Vaccine. 2018, 36: 4621-4632.
Tan Z., Liu L., Chiu M.S., Cheung K.W., Yan C.W., Yu Z., LEE B.K., LIU W., Man K. and Chen Z., Virotherapy-recruited PMN-MDSC infiltration of mesothelioma blocks antitumor CTL by IL-10-mediated dendritic cell suppression, OncoImmunology. 2019, 8: e1518672.


Researcher : Lai KK

List of Research Outputs

Chan J.F.W., Yuan S., CHIK K.K.H., Yip C.Y., Tee K.M., Lai K.K., Kao R.Y.T. and Yuen K.Y., Repurposing novobiocin as a flavivirus protease inhibitor, 67th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2018). 2018.


Researcher : Lai PM

List of Research Outputs

Yan B., Chu H., Yang D., Sze K.H., Lai P.M., Yuan S., Shuai H.V., Wang Y., Kao R.Y.T., Chan J.F.W. and Yuen K.Y., Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication, Viruses. 2019, 11: 73.


Researcher : Lai SK

List of Research Outputs

Lau S.K.P., ZHAO S., Sridhar S., Yip C.Y., AW YONG K.L., Chow E.Y.Y., Cheung K.C.M., Hui R.W.H., Leung R.Y.H., Lai S.K., Wu A.K.L., To K.K.W., Woo P.C.Y. and Yuen K.Y., Molecular epidemiology of coxsackievirus A6 circulating in Hong Kong reveals common neurological manifestations and emergence of novel recombinant groups, Journal of Clinical Virology. 2018, 108: 43-49.


Researcher : Lam CMV

List of Research Outputs

Wong C.Y.S., Poon W.S.R., Foo C.H., Ngan A.H.Y., Tse H., Lam C.M.V., Leung H.Y., Wong C.P., Cheng C.C.V., Chen H.K.J. and Yuen K.Y., Novel selective medium for the isolation of corynebacterium kroppenstedtii from heavily colonised clinical specimens , Journal of Clinical Pathology. 2018, 71: 781-786.


Researcher : Lam JY

List of Research Outputs

Zhu H., Lee C.Y., Li C., Mak W.N., Chen Y., Chan K.H., Zhang J., Fung W.F., Zhang R.Q., Fung Y.F., Poon W.S.R., Lam J.Y., Tam S., Hung F.N.I., Chen H., Yuen K.Y. and To K.K.W., Low population serum microneutralization antibody titer against the predominating influenza A(H3N2) N121K virus during the severe influenza summer peak of Hong Kong in 2017, Emerging Microbes & Infections. New York, NPG, 2018, 7: 23.


Researcher : Lau S.K.P.

Project Title:Matrix-assisted laser desorption ionization time-of-flight mass spectrometry for rapid identification of Penicillium marneffei
Investigator(s):Lau SKP, Woo PCY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:01/2015


Project Title:Characterization of mycoviruses in the thermally dimorphic fungus Talaromyces marneffei
Investigator(s):Lau SKP, Woo PCY
Department:Microbiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:01/2017
Completion Date:12/2018


Project Title:Molecular diversity and evolution of bat alphacoronaviruses: implications on emergence potential and mechanism of interspecies transmission
Investigator(s):Lau SKP, Woo PCY
Department:Microbiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2018


Project Title:Characterization of secretions in Talaromyces marneffei – proteomics and transcriptomics approaches
Investigator(s):Lau SKP, Woo PCY, Chow WNF, Tsang CC
Department:Microbiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:04/2019


Project Title:Development of a panfungal vaccine for invasive mycotic infections
Investigator(s):Lau SKP, Woo PCY, Chow WNF, Tsang CC
Department:Microbiology
Source(s) of Funding:Seed Fund for Translational and Applied Research
Start Date:04/2019


List of Research Outputs



Researcher : Lau SKP

Project Title:Matrix-assisted laser desorption ionization time-of-flight mass spectrometry for rapid identification of Penicillium marneffei
Investigator(s):Lau SKP, Woo PCY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:01/2015


Project Title:Characterization of mycoviruses in the thermally dimorphic fungus Talaromyces marneffei
Investigator(s):Lau SKP, Woo PCY
Department:Microbiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:01/2017
Completion Date:12/2018


Project Title:Molecular diversity and evolution of bat alphacoronaviruses: implications on emergence potential and mechanism of interspecies transmission
Investigator(s):Lau SKP, Woo PCY
Department:Microbiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2018


Project Title:Characterization of secretions in Talaromyces marneffei – proteomics and transcriptomics approaches
Investigator(s):Lau SKP, Woo PCY, Chow WNF, Tsang CC
Department:Microbiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:04/2019


Project Title:Development of a panfungal vaccine for invasive mycotic infections
Investigator(s):Lau SKP, Woo PCY, Chow WNF, Tsang CC
Department:Microbiology
Source(s) of Funding:Seed Fund for Translational and Applied Research
Start Date:04/2019


List of Research Outputs

Chan E., Wu K.L.A., Tse C.W.S., Lau S.K.P. and Woo P.C.Y., In vitro susceptibility of ceftolozane-tazobactam against Salmonella enterica Serovar Typhi., Journal of Antimicrobial Chemotherapy. 2018, 74: 528-530.
Chan J.F.W., TSANG O.L., ZOU Z., CHIK K.K.H., Yuan S., Chu H., Lau S.K.P. and Yuen K.Y., The Cellular Kinase Inhibitor OSU-03012 Inhibits Enterovirus 71 In Vitro, Annual Meeting of the Infectious Diseases Society of America, IDWeek 2018.
Chong Y.K., Ho C.C., Leung S.Y., Lau S.K.P. and Woo P.C.Y., Clinical Mass Spectrometry in the Bioinformatics Era: A Hitchhiker’s Guide, Computational and Structural Biotechnology Journal. 2018, 16: 316-334.
Chong Y.K., Ho C.C., Leung S.Y., Lau S.K.P. and Woo P.C.Y., Clinical Mass Spectrometry in the Bioinformatics Era: A Hitchhiker’s Guide, Computational and Structural Biotechnology Journal. 2018, 16: 316-334.
Churgin S.M., Teng L.L., Ho J.H.P., Graydon R., Martelli P., Lee F.K., Hui S.W., Fong J.Y.H., Lau S.K.P. and Woo P.C.Y., First case report of fatal Nocardia nova infection in yellow-bibbed lory (Lorius chlorocercus) identified by multilocus sequencing, BMC Veterinary Research. 2019, 15: 4.
Guan T.P., Teng L.L., Yeong K.Y., You Z.Q., Liu H., Wong S.S.Y., Lau S.K.P. and Woo P.C.Y., Metagenomic Analysis Of Sichuan Takin Fecal Sample Viromes Reveals Novel Enterovirus And Astrovirus, Virology. 2018, 521: 77-91.
Lam W.H., Sze K.H., Ke Y., Tse M.K., Zhang H., Woo P.C.Y., Lau S.K.P., Lau C.C.Y., Xu S., Lai P.M., Zhou T., Antonyuk S.V., Kao R.Y.T., Yuen K.Y. and Hao Q., Talaromyces marneffei Mp1 Protein, a Novel Virulence Factor, Carries Two Arachidonic Acid-Binding Domains To Suppress Inflammatory Responses in Hosts , Infection and Immunity. 2019, 87.
Lau S.K.P., Bats as possible animal origin of MERS-CoV, Taiwan Society of Microbiology 50th anniversary meeting. (Taipei) . 2018.
Lau S.K.P., Bats as potential animal origin of MERS coronavirus. , Wildlife and exotic veterinary medicine conference 2019. (Hong Kong) . 2019.
Lau S.K.P., Xing F., Tsang C.C., TANG Y.M., TAN Y.P., Ye H., Lau R.W.T., Chen H.K.J., Lo S.K.F. and Woo P.C.Y., Clinical characteristics, rapid identification, molecular epidemiology and antifungal susceptibilities of Talaromyces marneffei infections in Shenzhen, China, Mycoses. 2019, 62: 450-457.
Lau S.K.P., Wong Y.M., Tsang C.C., Ahmed S.S., Au Yeung K.H.R., Yuen K.Y., Wernery U. and Woo P.C.Y., Discovery and sequence analysis of four deltacoronaviruses from birds in the Middle East reveal interspecies jumping with recombination as a potential mechanism for avian-to-avian and avian-to-mammalian transmission, Journal of Virology. 2018, 92: e00265-18.
Lau S.K.P., Emerging coronaviruses: lesson from OC43, SARS and MERS. , Institute of Animal Health, Guangdong Academy of Agricultural Sciences. (Guangzhou). 2018.
Lau S.K.P., Invasive Aspergillosis Associated With Influenza In Hong Kong. 5th Asia Care Forum 2018. (seoul, South Korea) (july 2018), Seoul, South Korea. 2018.
Lau S.K.P., Invasive aspergillosis associated with influenza in Hong Kong, 5th Asia CARE Forum 2018. 2018.
Lau S.K.P., ZHAO S., Sridhar S., Yip C.Y., AW YONG K.L., Chow E.Y.Y., Cheung K.C.M., Hui R.W.H., Leung R.Y.H., Lai S.K., Wu A.K.L., To K.K.W., Woo P.C.Y. and Yuen K.Y., Molecular epidemiology of coxsackievirus A6 circulating in Hong Kong reveals common neurological manifestations and emergence of novel recombinant groups, Journal of Clinical Virology. 2018, 108: 43-49.
Lau S.K.P., Wong A.C.P., Zhang L., Luk H.K.H., Kwok J.S.L., Ahmed S.S., Cai J., Zhao P.S.H., Teng L.L., Tsui S.K.W., Yuen K.Y. and Woo P.C.Y., Novel Bat Alphacoronaviruses in Southern China Support Chinese Horseshoe Bats as an Important Reservoir for Potential Novel Coronaviruses, Viruses. 2019, 11: 423.
Lau S.K.P. and Woo P.C.Y., Pitfalls in big data analysis: next generation technologies, last generation data, Diagnostic Microbiology and Infectious Disease. 2019, 94: 209-210.
Lau S.K.P., Fan R.Y.Y., Luk H.K.H., Zhu L., Fung J., Li K.S.M., Wong W.Y.M., Ahmed S.S., Chan J.F.W., Kok K.H., Chan K.H., Wernery U., Yuen K.Y. and Woo P.C.Y., Replication of MERS and SARS coronaviruses in bat cells offers insights to their ancestral origins, Emerging Microbes & Infections. 2018, 7: 1-11.
Luk K.H., Li X., FUNG J., Lau S.K.P. and Woo P.C.Y., Molecular epidemiology, evolution and phylogeny of SARS coronavirus, Infection, Genetics and Evolution. 2019, 71: 21-30.
Sridhar S., Cheng C.C.V., Wong S.C., Yip C.Y., Wu S., Lo A.W.I., Leung K.H., Mak W.N., Cai J., Li X., Chan J.F.W., Lau S.K.P., Woo P.C.Y., Lai W.M., Kwan T.H., Au T.W.K., Lo C.M., Wong C.Y.S. and Yuen K.Y., Donor-Derived Genotype 4 Hepatitis E Virus Infection, Hong Kong, China, 2018, Emerging Infectious Diseases. 2019, 25: 425-433.
Sridhar S., Chung T.W.H., Chan J.F.W., Cheng C.C.V., Lau S.K.P., Yuen K.Y. and Woo P.C.Y., Emergence of Cytomegalovirus Mononucleosis Syndrome Among Young Adults in Hong Kong Linked to Falling Seroprevalence: Results of a 14-Year Seroepidemiological Study, Open Forum Infectious Diseases. 2018, 5.
Sridhar S., Yip C.Y., Wu S., Cai J., Zhang J., Leung K.H., Chung T.W.H., Chan J.F.W., Chan W.M., Teng L.L., Au-Yeung R.K.H., Cheng C.C.V., Chen H., Lau S.K.P., Woo P.C.Y., Xia N.S., Lo C.M. and Yuen K.Y., Rat Hepatitis E Virus as Cause of Persistent Hepatitis after Liver Transplant, Emerging Infectious Diseases. 2018, 24: 2241-2250.
Teng L.L., Tang Y., Wong S.S.Y., Fong Y.H., Zhao Z.H.E., Wong C.P., Chen H.K.J., Ngan A.K.L., Wu K.L.A., Fung S.C.K., Que T.L., Lau S.K.P. and Woo P.C.Y., Maldi-tof Ms For Identification Of Tsukamurella Species: Tsukamurella Tyrosinosolvens As The Predominant Species Associated With Ocular Infections, Emerging Microbes & Infections. 2018, 7.
Tsang C.C., TANG Y.M., CHAN K.F., Lee C.Y., Chan J.F.W., Ngan A.H.Y., Cheung M., Lau E.C.L., Li X., Ng R.H.Y., Lai C.K.C., Fung S.C.K., Lau S.K.P. and Woo P.C.Y., Diversity of phenotypically non-dermatophyte, non-Aspergillus filamentous fungi causing nail infections: importance of accurate identification and antifungal susceptibility testing, Emerging Microbes & Infections. 2019, 8: 531-541.
Tsang C.C., TANG Y.M., FONG Y.H., Kinne J., LEE H.H., Joseph M., Jose S., Schuster R.K., Tang Y., Sivakumar S., Chen H.K.J., Teng L.L., Lau S.K.P., Wernery U. and Woo P.C.Y., Ignatzschineria cameli sp. nov., isolated from necrotic foot tissue of dromedaries (Camelus dromedarius) and associated maggots (Wohlfahrtia species) in Dubai, International Journal of Systematic and Evolutionary Microbiology. 2018, 68: 3627-3634.
Wang L., Teng L.L., Lau S.K.P., Sridhar S., Fu H., Gong W., Li M., Xu Q., He Y., Zhuang H., Woo P.C.Y. and Wang L., Transmission of a Novel Genotype of Hepatitis E Virus from Bactrian Camels to Cynomolgus Macaques, Journal of Virology. 2019, 93.
Wen W.E.I., Xiong L., Ye Y.N., Du M.Z., Gao Y.Z., Zhang K.Y., Jin Y.T., Yang Z.J., Wong P.C., Lau S.K.P., Kan B., Zhu J., Woo P.C.Y. and Guo F.B., Mutation Landscape Of Base Substitutions, Duplications And Deletions In The Representative Current Cholera Pandemic Strain, Genome Biology And Evolution. 2018.
Wernery U., Tsang C.C., Hebel C., Damerau A., Kinne J., Cai J., Küspert H., Chan K.F., Joseph M., XUE S., Raghavan R., Tang Y.M.J., Syriac G., Lau S.K.P., Jose S. and Woo P.C.Y., Serodiagnosis of aspergillosis in falcons (Falco spp.) by an Afmp1p-based enzyme-linked immunosorbent assay, Mycoses. Blackwell Verlag GmbH, 2018, 61: 600-609.
Wong C.P., Li X., Lau S.K.P. and Woo P.C.Y., Global Epidemiology of Bat Coronaviruses, Viruses. 2019, 11(2): 174.
Woo P.C.Y., Teng L.L., Bai R., Tang Y., Wong A.Y.P., Li K.S.M., Lam C.S.F., Fan R.Y.Y., Lau S.K.P. and Yuen K.Y., Novel Picobirnaviruses in Respiratory and Alimentary Tracts of Cattle and Monkeys with Large Intra- and Inter-Host Diversity, Viruses. 2019, 11: 574.
Yeung M.L., JIA L., Yip C.Y., Chan J.F.W., Teng L.L., Chan K.H., Cai J., ZHANG C., Zhang J., Wong L.W.M., Kok K.H., Lau S.K.P., Woo P.C.Y., Lo J.Y.C., Jin D., Shih S.R. and Yuen K.Y., Human tryptophanyl-tRNA synthetase is an IFN-γ–inducible entry factor for Enterovirus, Journal of Clinical Investigation. 2018, 128: 5163-5177.
Zhang J., Kang J., Dehghan S., Sridhar S., Lau S.K.P., Ou J., Woo P.C.Y., Zhang Q. and Seto D., A survey of recent adenoviral respiratory pathogens in Hong Kong reveals emergent and recombinant human adenovirus type 4 (HAdV-E4) circulating in civilian populations, Viruses. 2019, 11(2): 129.
Zhao Y., Tsang C.C., Xiao M., Chan J.F.W., Lau S.K.P., Kong F., Xu Y. and Woo P.C.Y., Yeast identification by sequencing, biochemical kits, MALDI–TOF MS and rep-PCR DNA fingerprinting, Yeast identification by sequencing, biochemical kits, MALDI–TOF MS and rep-PCR DNA fingerprinting. 2018, 56: 816–827.
Zhou P.S.H., Yip C.Y., Sridhar S., Chow W.N., To K.K.W., Chan K.H., Chan J.F.W., Cheng C.C.V., Yuen K.Y., Woo P.C.Y. and Lau S.K.P., Identification And Characteristics Of The Newly Emerged Subclades Of Enterovirus D68 Associated With Severe Respiratory/central Nervous System Infections In Hong Kong. Australia Society For Microbiology Annual Scientific Meeting 2018, (Brisbane, Australia). 2018.


Researcher : Lau SYP

List of Research Outputs

Mok B.W.Y., LIU H., Lau S.Y.P., Yuen K.Y. and Chen H., New role of the Influenza NS1 protein: Induction of miR-146a-5p for virus replication through epigenetic mechanism, Chromatin and Epigenetics EMBO WORKSHOP, 1 - 4 May, 2019, Heidelberg, Germany. 2019.
Wang P., Song W., Mok B.W.Y., Zheng M., Lau S.Y.P., Liu S., CHEN P., Huang X., LIU H., CREMIN C.J. and Chen H., The PB2 Polymerase Host Adaptation Substitutions Prime Avian Indonesia Sub Clade 2.1 H5N1 Viruses for Infecting Humans, Viruses. Switerland, MDPI, 2019, 11: 292.


Researcher : Lee CY

List of Research Outputs

Lee C.Y., Zhang J., Chu H., Li C., Zhu H., Mak W.W.N., Chen Y., Kok K.H., To K.K.W. and Yuen K.Y., H7N9 influenza A virus activation of necroptosis in human monocytes links innate and adaptive immune responses, Cell Death & Disease. 2019, 10.
Li C., To K.K.W., Zhang J., Lee C.Y., Zhu H., Mak W.N., Hung F.N.I. and Yuen K.Y., Co-stimulation With TLR7 Agonist Imiquimod and Inactivated Influenza Virus Particles Promotes Mouse B Cell Activation, Differentiation, and Accelerated Antigen Specific Antibody Production., Frontiers in Immunology. 2018, 9.
Meyer W., Irinyi L., Hoang M.T.V., Robert V., Garcia-Hermoso D., Desnos-Ollivier M., Yurayart C., Tsang C.C., Lee C.Y., Woo P.C.Y., Pchelin I.M., Uhrlaß S., Nenoff P., Chindamporn A., Chen S., Hebert P.D.N. and Sorrell T.C., Database establishment for the secondary fungal DNA barcode -Translational Elongation Factor 1α (TEF1α), Genome. Canadian Science Publishing, 2019, 62: 160-169.
Tsang C.C., TANG Y.M., CHAN K.F., Lee C.Y., Chan J.F.W., Ngan A.H.Y., Cheung M., Lau E.C.L., Li X., Ng R.H.Y., Lai C.K.C., Fung S.C.K., Lau S.K.P. and Woo P.C.Y., Diversity of phenotypically non-dermatophyte, non-Aspergillus filamentous fungi causing nail infections: importance of accurate identification and antifungal susceptibility testing, Emerging Microbes & Infections. 2019, 8: 531-541.
Zhang J., ZHU H., Chen Y., LI C., Li C., Gozali L., Lee C.Y., To K.K.W., Hung F.N.I. and Yuen K.Y., Prostaglandin E2-mediated impairment of innate immune response to A(H1N1)pdm09 infection in diet-induced obese mice could be restored by paracetamol , Journal of Infectious Diseases. 2018.
Zhu H., Lee C.Y., Li C., Mak W.N., Chen Y., Chan K.H., Zhang J., Fung W.F., Zhang R.Q., Fung Y.F., Poon W.S.R., Lam J.Y., Tam S., Hung F.N.I., Chen H., Yuen K.Y. and To K.K.W., Low population serum microneutralization antibody titer against the predominating influenza A(H3N2) N121K virus during the severe influenza summer peak of Hong Kong in 2017, Emerging Microbes & Infections. New York, NPG, 2018, 7: 23.


Researcher : Lee MY

Project Title:Direct identification and quantification of host and viral microRNAs after influenza infection using the next generation ultra-high throughput DNA sequencer
Investigator(s):Lee MY, Lok S, Cheung CY
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:05/2009


Project Title:Innate lymphoid cell "adaptation" during influenza virus infection
Investigator(s):Lee MY, Peiris JSM, Cowling BJ, Bruzzone R
Department:School of Public Health
Source(s) of Funding:France/Hong Kong Joint Research Scheme - Travel Grants
Start Date:01/2017
Completion Date:12/2018


Project Title:Effect of Volatile Organic Compounds (VOCs) exposure on disease severity in influenza virus infection
Investigator(s):Lee MY, Yan S
Department:School of Public Health
Source(s) of Funding:Seed Fund for Basic Research
Start Date:05/2017




Researcher : Leung ASP

List of Research Outputs

Chu H., Chan C.M., Zhang X., Wang Y., Yuan S., Zhou J., Au Yeung K.H.R., Sze K.H., Yang D., Shuai H.V., Hou Y., Li C., Zhao X., Poon K.M., Leung A.S.P., Yeung M.L., Yan J., Lu G., Jin D., Gao G.F., Chan J.F.W. and Yuen K.Y., Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells, Journal of Biological Chemistry. 2018, 293: 11709-11726.


Researcher : Leung HY

List of Research Outputs

Wong C.Y.S., Poon W.S.R., Foo C.H., Ngan A.H.Y., Tse H., Lam C.M.V., Leung H.Y., Wong C.P., Cheng C.C.V., Chen H.K.J. and Yuen K.Y., Novel selective medium for the isolation of corynebacterium kroppenstedtii from heavily colonised clinical specimens , Journal of Clinical Pathology. 2018, 71: 781-786.


Researcher : Leung KC

List of Research Outputs

TAM K.G.K., Leung S.S., Siu G.K.H., CHANG K.C., Wong S.S.Y., Ho P.L., Leung K.C. and Yam W.C., Direct detection of pyrazinamide resistance in Mycobacterium tuberculosis by use of pncA PCR sequencing. , Journal of Clinical Microbiology. American Society of Microbiology, 2019, 57.


Researcher : Leung KH

List of Research Outputs

Sridhar S., Cheng C.C.V., Wong S.C., Yip C.Y., Wu S., Lo A.W.I., Leung K.H., Mak W.N., Cai J., Li X., Chan J.F.W., Lau S.K.P., Woo P.C.Y., Lai W.M., Kwan T.H., Au T.W.K., Lo C.M., Wong C.Y.S. and Yuen K.Y., Donor-Derived Genotype 4 Hepatitis E Virus Infection, Hong Kong, China, 2018, Emerging Infectious Diseases. 2019, 25: 425-433.
Sridhar S., Yip C.Y., Wu S., Cai J., Zhang J., Leung K.H., Chung T.W.H., Chan J.F.W., Chan W.M., Teng L.L., Au-Yeung R.K.H., Cheng C.C.V., Chen H., Lau S.K.P., Woo P.C.Y., Xia N.S., Lo C.M. and Yuen K.Y., Rat Hepatitis E Virus as Cause of Persistent Hepatitis after Liver Transplant, Emerging Infectious Diseases. 2018, 24: 2241-2250.
Wong S.S.Y., Yip C.Y., Sridhar S., Leung K.H., Cheng A.K.W., Fung A.M.Y., Lam H.Y., Chan K.H., Chan J.F.W., Cheng C.C.V., Tang B.S.F. and Yuen K.Y., Comparative evaluation of a laboratory-developed real-time PCR assay and RealStar® Adenovirus PCR Kit for quantitative detection of human adenovirus, Virology Journal. 2018, 15.


Researcher : Leung SS

List of Research Outputs

TAM K.G.K., Leung S.S., Siu G.K.H., CHANG K.C., Wong S.S.Y., Ho P.L., Leung K.C. and Yam W.C., Direct detection of pyrazinamide resistance in Mycobacterium tuberculosis by use of pncA PCR sequencing. , Journal of Clinical Microbiology. American Society of Microbiology, 2019, 57.


Researcher : Li C

Project Title:the London Infections and Immunity Symposium; Co-stimulation with TLR7 agonist imiquimod and inactivated influenza virus particles promotes mouse B cell activation, differentiation and accelerated antigen specific antibody production
Investigator(s):Li C
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:11/2018
Completion Date:11/2018


List of Research Outputs

Chu H., Chan C.M., Zhang X., Wang Y., Yuan S., Zhou J., Au Yeung K.H.R., Sze K.H., Yang D., Shuai H.V., Hou Y., Li C., Zhao X., Poon K.M., Leung A.S.P., Yeung M.L., Yan J., Lu G., Jin D., Gao G.F., Chan J.F.W. and Yuen K.Y., Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells, Journal of Biological Chemistry. 2018, 293: 11709-11726.
Lee C.Y., Zhang J., Chu H., Li C., Zhu H., Mak W.W.N., Chen Y., Kok K.H., To K.K.W. and Yuen K.Y., H7N9 influenza A virus activation of necroptosis in human monocytes links innate and adaptive immune responses, Cell Death & Disease. 2019, 10.
Li C., To K.K.W., Zhang J., Lee C.Y., Zhu H., Mak W.N., Hung F.N.I. and Yuen K.Y., Co-stimulation With TLR7 Agonist Imiquimod and Inactivated Influenza Virus Particles Promotes Mouse B Cell Activation, Differentiation, and Accelerated Antigen Specific Antibody Production., Frontiers in Immunology. 2018, 9.
Lui W.Y., Yuen C.K., Li C., Wong W.M., Lui P.Y., Lin C.H., Chan K.H., Zhao H., Chen H., To K.K.W., Zhang J., Yuen K.Y. and Kok K.H., SMRT sequencing revealed the diversity and characteristics of defective interfering RNAs in influenza A (H7N9) virus infection, Emerging Microbes & Infections. 2019, 8: 662-674.
Wen L.R., Chu H., Wong H.Y.B., Wang D., Li C., Zhao X., Chiu M.C., Yuan S., Fan Y., Chen H., Zhou J. and Yuen K.Y., Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses, Emerging Microbes & Infections. New York, USA, NPG, 2018, 7.
Zhang J., ZHU H., Chen Y., LI C., Li C., Gozali L., Lee C.Y., To K.K.W., Hung F.N.I. and Yuen K.Y., Prostaglandin E2-mediated impairment of innate immune response to A(H1N1)pdm09 infection in diet-induced obese mice could be restored by paracetamol , Journal of Infectious Diseases. 2018.
Zhang K., Li C., Luo Y.S., Wen L.R., Yuan S., Wang D., WONG H.Y.B., Zhao X., Chiu M.C., Ye Z., Sun Z., Zhao H., ZHANG X., Hu M., Yang D., Shuai H.V., Wang Y., He J., Bose M.E., Henrickson K.J., Huang J., Zheng B., Chu H. and Zhou J., Establishment of a lethal aged mouse model of human respiratory syncytial virus infection, Antiviral Research. 2019, 161: 125-133.
Zhao H., To K.K.W., Chu H., Ding Q., Zhao X., Li C., Shuai H.V., Yuan S., Zhou J., Kok K.H., Jiang S. and Yuen K.Y., Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza, Nature Communications. 2018, 9.
Zhu H., Lee C.Y., Li C., Mak W.N., Chen Y., Chan K.H., Zhang J., Fung W.F., Zhang R.Q., Fung Y.F., Poon W.S.R., Lam J.Y., Tam S., Hung F.N.I., Chen H., Yuen K.Y. and To K.K.W., Low population serum microneutralization antibody titer against the predominating influenza A(H3N2) N121K virus during the severe influenza summer peak of Hong Kong in 2017, Emerging Microbes & Infections. New York, NPG, 2018, 7: 23.


Researcher : Li C

List of Research Outputs

Chu H., Chan C.M., Zhang X., Wang Y., Yuan S., Zhou J., Au Yeung K.H.R., Sze K.H., Yang D., Shuai H.V., Hou Y., Li C., Zhao X., Poon K.M., Leung A.S.P., Yeung M.L., Yan J., Lu G., Jin D., Gao G.F., Chan J.F.W. and Yuen K.Y., Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells, Journal of Biological Chemistry. 2018, 293: 11709-11726.
Lee C.Y., Zhang J., Chu H., Li C., Zhu H., Mak W.W.N., Chen Y., Kok K.H., To K.K.W. and Yuen K.Y., H7N9 influenza A virus activation of necroptosis in human monocytes links innate and adaptive immune responses, Cell Death & Disease. 2019, 10.
Li C., To K.K.W., Zhang J., Lee C.Y., Zhu H., Mak W.N., Hung F.N.I. and Yuen K.Y., Co-stimulation With TLR7 Agonist Imiquimod and Inactivated Influenza Virus Particles Promotes Mouse B Cell Activation, Differentiation, and Accelerated Antigen Specific Antibody Production., Frontiers in Immunology. 2018, 9.
Lui W.Y., Yuen C.K., Li C., Wong W.M., Lui P.Y., Lin C.H., Chan K.H., Zhao H., Chen H., To K.K.W., Zhang J., Yuen K.Y. and Kok K.H., SMRT sequencing revealed the diversity and characteristics of defective interfering RNAs in influenza A (H7N9) virus infection, Emerging Microbes & Infections. 2019, 8: 662-674.
Wen L.R., Chu H., Wong H.Y.B., Wang D., Li C., Zhao X., Chiu M.C., Yuan S., Fan Y., Chen H., Zhou J. and Yuen K.Y., Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses, Emerging Microbes & Infections. New York, USA, NPG, 2018, 7.
Zhang J., ZHU H., Chen Y., LI C., Li C., Gozali L., Lee C.Y., To K.K.W., Hung F.N.I. and Yuen K.Y., Prostaglandin E2-mediated impairment of innate immune response to A(H1N1)pdm09 infection in diet-induced obese mice could be restored by paracetamol , Journal of Infectious Diseases. 2018.
Zhang K., Li C., Luo Y.S., Wen L.R., Yuan S., Wang D., WONG H.Y.B., Zhao X., Chiu M.C., Ye Z., Sun Z., Zhao H., ZHANG X., Hu M., Yang D., Shuai H.V., Wang Y., He J., Bose M.E., Henrickson K.J., Huang J., Zheng B., Chu H. and Zhou J., Establishment of a lethal aged mouse model of human respiratory syncytial virus infection, Antiviral Research. 2019, 161: 125-133.
Zhao H., To K.K.W., Chu H., Ding Q., Zhao X., Li C., Shuai H.V., Yuan S., Zhou J., Kok K.H., Jiang S. and Yuen K.Y., Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza, Nature Communications. 2018, 9.
Zhu H., Lee C.Y., Li C., Mak W.N., Chen Y., Chan K.H., Zhang J., Fung W.F., Zhang R.Q., Fung Y.F., Poon W.S.R., Lam J.Y., Tam S., Hung F.N.I., Chen H., Yuen K.Y. and To K.K.W., Low population serum microneutralization antibody titer against the predominating influenza A(H3N2) N121K virus during the severe influenza summer peak of Hong Kong in 2017, Emerging Microbes & Infections. New York, NPG, 2018, 7: 23.


Researcher : Li X

List of Research Outputs

Luk K.H., Li X., FUNG J., Lau S.K.P. and Woo P.C.Y., Molecular epidemiology, evolution and phylogeny of SARS coronavirus, Infection, Genetics and Evolution. 2019, 71: 21-30.
Sridhar S., Cheng C.C.V., Wong S.C., Yip C.Y., Wu S., Lo A.W.I., Leung K.H., Mak W.N., Cai J., Li X., Chan J.F.W., Lau S.K.P., Woo P.C.Y., Lai W.M., Kwan T.H., Au T.W.K., Lo C.M., Wong C.Y.S. and Yuen K.Y., Donor-Derived Genotype 4 Hepatitis E Virus Infection, Hong Kong, China, 2018, Emerging Infectious Diseases. 2019, 25: 425-433.
Tsang C.C., TANG Y.M., CHAN K.F., Lee C.Y., Chan J.F.W., Ngan A.H.Y., Cheung M., Lau E.C.L., Li X., Ng R.H.Y., Lai C.K.C., Fung S.C.K., Lau S.K.P. and Woo P.C.Y., Diversity of phenotypically non-dermatophyte, non-Aspergillus filamentous fungi causing nail infections: importance of accurate identification and antifungal susceptibility testing, Emerging Microbes & Infections. 2019, 8: 531-541.
Wong C.P., Li X., Lau S.K.P. and Woo P.C.Y., Global Epidemiology of Bat Coronaviruses, Viruses. 2019, 11(2): 174.


Researcher : Li X

List of Research Outputs

Luk K.H., Li X., FUNG J., Lau S.K.P. and Woo P.C.Y., Molecular epidemiology, evolution and phylogeny of SARS coronavirus, Infection, Genetics and Evolution. 2019, 71: 21-30.
Sridhar S., Cheng C.C.V., Wong S.C., Yip C.Y., Wu S., Lo A.W.I., Leung K.H., Mak W.N., Cai J., Li X., Chan J.F.W., Lau S.K.P., Woo P.C.Y., Lai W.M., Kwan T.H., Au T.W.K., Lo C.M., Wong C.Y.S. and Yuen K.Y., Donor-Derived Genotype 4 Hepatitis E Virus Infection, Hong Kong, China, 2018, Emerging Infectious Diseases. 2019, 25: 425-433.
Tsang C.C., TANG Y.M., CHAN K.F., Lee C.Y., Chan J.F.W., Ngan A.H.Y., Cheung M., Lau E.C.L., Li X., Ng R.H.Y., Lai C.K.C., Fung S.C.K., Lau S.K.P. and Woo P.C.Y., Diversity of phenotypically non-dermatophyte, non-Aspergillus filamentous fungi causing nail infections: importance of accurate identification and antifungal susceptibility testing, Emerging Microbes & Infections. 2019, 8: 531-541.
Wong C.P., Li X., Lau S.K.P. and Woo P.C.Y., Global Epidemiology of Bat Coronaviruses, Viruses. 2019, 11(2): 174.


Researcher : Liu L

Project Title:Early HIV-1 diagnosis using in-house real-time PCR amplification on dried blood spots for men who have sex with men in Hong Kong
Investigator(s):Liu L
Department:LKS Medical Faculty
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:09/2009


Project Title:Therapeutic potential of regulatory T cells in limiting HIV reservoir in the brain without triggering detrimental neuroinflammation
Investigator(s):Liu L, Chen Z
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2017


Project Title:Role of Δ42PD-1 in B-cell dysfunction during HIV infection
Investigator(s):Liu L
Department:Microbiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2017
Completion Date:06/2019


Project Title:IMMUNOLOGY 2019; Daidzein and its analogs reactivate HIV replication from latently infected CD4 T cells
Investigator(s):Liu L
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:05/2019


Project Title:Role of Δ42PD-1 in memory B cells exhaustion in HIV-infected viremic individuals
Investigator(s):Liu L, Chen Z
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:06/2019


List of Research Outputs

Chen Z., Liu L., Chen G., Cheung K.W., Du D.Y., Yao X., Lu Y., Chen L., Lin X. and Chen Z., Surging HIV-1 CRF07_BC epidemic among recently infected men who have sex with men in Fujian, China, Journal of Medical Virology. 2018, 90: 1210-1221.
Liu L., Wei Q., Lin Q., Fang J., Wang H., Kwok H.Y., Tang H.Y., Nishiura K., Peng J., Wu T., Wu T., Cheung K.W., Chan K.H., Alvarez X., Qin C., Lackner A., Perlman S., Yuen K.Y. and Chen Z., Anti–spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection, JCI Insight. 2019, 4.
Liu L., Liang J., Lu X. and Chen Z., Daidzein and its analogs reactivate HIV replication from latently infected CD4 T cells, Immunology 2019.
PANG L., Ng K.T.P., Liu J., Liu H., Liu L., Chen Z. and Man K., ILTS Travel Award - Plasmacytoid dendritic cells promote hepatocellular carcinoma recurrence after liver transplantation, ILTS 25th Annual International Congress, May 2019, Toronto, Canada. 2019.
PANG L., Ng K.T.P., Liu J., Liu H., Liu L., Chen Z. and Man K., Plasmacytoid dendritic cells promote hepatocellular carcinoma recurrence after liver transplantation, International Liver Transplant Society 25th Annual Congress, Toronto, Canada, 15-18 May 2019.
Tan Z., Liu L., Chiu M.S., Cheung K.W., Yan C.W., Yu Z., LEE B.K., LIU W., Man K. and Chen Z., Virotherapy-recruited PMN-MDSC infiltration of mesothelioma blocks antitumor CTL by IL-10-mediated dendritic cell suppression, OncoImmunology. 2019, 8: e1518672.


Researcher : Liu S

List of Research Outputs

Wang P., Song W., Mok B.W.Y., Zheng M., Lau S.Y.P., Liu S., CHEN P., Huang X., LIU H., CREMIN C.J. and Chen H., The PB2 Polymerase Host Adaptation Substitutions Prime Avian Indonesia Sub Clade 2.1 H5N1 Viruses for Infecting Humans, Viruses. Switerland, MDPI, 2019, 11: 292.


Researcher : Lui PY

List of Research Outputs

Chan C.P., Yuen C.K.J., CHEUNG P.H.H., Fung S.Y., Lui P.Y., Chen H., Kok K.H. and Jin D., Antiviral activity of double-stranded RNA–binding protein PACT against influenza A virus mediated via suppression of viral RNA polymerase, The FASEB Journal. 2018, 32: 4380-4393.


Researcher : Luk KH

List of Research Outputs

Luk K.H., Li X., FUNG J., Lau S.K.P. and Woo P.C.Y., Molecular epidemiology, evolution and phylogeny of SARS coronavirus, Infection, Genetics and Evolution. 2019, 71: 21-30.


Researcher : Luk WK

List of Research Outputs

Wang Y.L., TONG M.K., Chow K.H., Cheng C.C.V., TSE C.W., Wu K.L.A., LAI R.W., Luk W.K., Tsang D.N.C. and Ho P.L., Occurrence of Highly Conjugative IncX3 Epidemic Plasmid Carrying blaNDM in Enterobacteriaceae Isolates in Geographically Widespread Areas, Frontiers in Microbiology. 2018, 9.


Researcher : Mak WN

List of Research Outputs

Li C., To K.K.W., Zhang J., Lee C.Y., Zhu H., Mak W.N., Hung F.N.I. and Yuen K.Y., Co-stimulation With TLR7 Agonist Imiquimod and Inactivated Influenza Virus Particles Promotes Mouse B Cell Activation, Differentiation, and Accelerated Antigen Specific Antibody Production., Frontiers in Immunology. 2018, 9.
Sridhar S., Cheng C.C.V., Wong S.C., Yip C.Y., Wu S., Lo A.W.I., Leung K.H., Mak W.N., Cai J., Li X., Chan J.F.W., Lau S.K.P., Woo P.C.Y., Lai W.M., Kwan T.H., Au T.W.K., Lo C.M., Wong C.Y.S. and Yuen K.Y., Donor-Derived Genotype 4 Hepatitis E Virus Infection, Hong Kong, China, 2018, Emerging Infectious Diseases. 2019, 25: 425-433.
Zhu H., Lee C.Y., Li C., Mak W.N., Chen Y., Chan K.H., Zhang J., Fung W.F., Zhang R.Q., Fung Y.F., Poon W.S.R., Lam J.Y., Tam S., Hung F.N.I., Chen H., Yuen K.Y. and To K.K.W., Low population serum microneutralization antibody titer against the predominating influenza A(H3N2) N121K virus during the severe influenza summer peak of Hong Kong in 2017, Emerging Microbes & Infections. New York, NPG, 2018, 7: 23.


Researcher : Mok BWY

Project Title:The role of influenza virus NS1 in miR-146a-mediated regulation of the innate immune response
Investigator(s):Mok BWY, Chen H
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:06/2014


Project Title:Exploring the role of influenza virus NS1 in microRNA-mediated regulation of the innate immune response
Investigator(s):Mok BWY, Chen H
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:08/2015
Completion Date:12/2018


List of Research Outputs

LIU J., Mok B.W.Y., Verhoeven R.J.A. and Chen H., Study of lnc-BARTs-KDM1B epigenetic modulatory complex in maintaining Epstein-Barr Virus latency in NPC cells, 2019 Cancer Genetics and Epigenetics, April 7 - 12, 2019, Renaissance Tuscany II Ciocco in Lucca (Barga) Italy.. 2019.
Mok B.W.Y., LIU H., Lau S.Y.P., Yuen K.Y. and Chen H., New role of the Influenza NS1 protein: Induction of miR-146a-5p for virus replication through epigenetic mechanism, Chromatin and Epigenetics EMBO WORKSHOP, 1 - 4 May, 2019, Heidelberg, Germany. 2019.
Wang P., Song W., Mok B.W.Y., Zheng M., Lau S.Y.P., Liu S., CHEN P., Huang X., LIU H., CREMIN C.J. and Chen H., The PB2 Polymerase Host Adaptation Substitutions Prime Avian Indonesia Sub Clade 2.1 H5N1 Viruses for Infecting Humans, Viruses. Switerland, MDPI, 2019, 11: 292.


Researcher : NIU M

List of Research Outputs

LING L., Wu T., To K.K.W., Cheung K.W., Lui K.O., NIU M., LAM K.S., Wang C.C., Li J., Wang H., Yuen K.Y. and Chen Z., Vedolizumab-mediated integrin α4β7 blockade does not control HIV-1SF162 rebound after combination antiretroviral therapy interruption in humanized mice, AIDS. 2019, 33: F1-F12.


Researcher : Ng SP

Project Title:Collection of background information on the alternative faecal indicators in the environmental waters of Hong Kong and their correlation with Escherichia coli
Investigator(s):Ng SP, Yam WC
Department:Microbiology
Source(s) of Funding:Environment Protection Department - General Award
Start Date:06/2001




Researcher : Peiris JSM

Project Title:IV International Symposium on Respiratory Viral Infections The Influenza Disease Burden in Hong Kong: the Rates of Hospitalisation in Children
Investigator(s):Peiris JSM
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:11/2001


Project Title:Influenza pandemic preparedness in Asia (Research collaboration with national Institute of Allergy and Infectious Diseases (NIAID), St. Jude Children's Research Hospital, Inc. (SJCRH) and The University of Hong Kong)
Investigator(s):Peiris JSM, Guan Y
Department:Microbiology
Source(s) of Funding:National Institutes of Health, US Department of Health and Human Services - General Award
Start Date:04/2003


Project Title:Virus-cell interaction and the pathogenesis of SARS
Investigator(s):Peiris JSM
Department:Microbiology
Source(s) of Funding:VCO SARS Research Fund
Start Date:07/2003


Project Title:Viral determinants underlying the increased secretion of pro-inflammatory cytokines in H5N1 infected human macrophages: a mechanism for the unusual severity of human H5N1 disease?
Investigator(s):Peiris JSM, Guan Y, Lau ASY, Poon LML
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2003


Project Title:Outstanding Researcher Award 2003-2004
Investigator(s):Peiris JSM
Department:School of Public Health
Source(s) of Funding:Outstanding Researcher Award
Start Date:07/2004


Project Title:Special Research Achievement Award 2003-2004
Investigator(s):Peiris JSM
Department:School of Public Health
Source(s) of Funding:Special Research Achievement Award
Start Date:11/2004


Project Title:The macrophage in the pathogenesis of Severe Acute Respiratory Syndrome Coronavirus infection
Investigator(s):Peiris JSM
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:12/2005


Project Title:The pathogenesis of avian influenza A H5N1 in humans: macrophage and epithelial cell-virus interactions in vitro and ex-vivo
Investigator(s):Peiris JSM
Department:Microbiology
Source(s) of Funding:The Wellcome Trust - General Award
Start Date:01/2007


Project Title:Communicable Diseases Surveillance and Response (CSR) - Standardization and shipment of PCR diagnostic kit for Avian Influenza detection to Member countries (viz: Bangladesh, Indonesia, Myanmar, Sri Lanka and Thailand)
Investigator(s):Peiris JSM
Department:Microbiology
Source(s) of Funding:Collaborating Project Fund
Start Date:06/2007


Project Title:Viral, Host and Environmental Determinants of Influenza Virus Transmission and Pathogenesis
Investigator(s):Peiris JSM, Cowling BJ, Guan Y, Li Y, Nicholls JM, Poon LML, Tu W, Yen H, Zhu H, Chan MCW, Lam TY, Jin D, Lee MY, Sanyal S, Mok KP, Sham PC
Department:School of Public Health
Source(s) of Funding:Theme-based Research Scheme
Start Date:01/2015


Project Title:Public Health Responses to threats of emerging, epidemic and endemic infectious diseases
Investigator(s):Peiris JSM, Cowling BJ, Wu JTK, Guan Y
Department:School of Public Health
Source(s) of Funding:Commissioned Research on Control of Infectious Diseases (Phase III)
Start Date:01/2015


Project Title:Role of influenza virus surface glycoproteins in virus-induced cell stress and inflammation
Investigator(s):Peiris JSM, Yen H
Department:School of Public Health
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:03/2015
Completion Date:10/2018


Project Title:HKU Centennial Distinguished Chinese Scholars Scheme 2015-16
Investigator(s):Peiris JSM
Department:School of Public Health
Source(s) of Funding:HKU Centennial Distinguished Chinese Scholars Scheme
Start Date:09/2015


Project Title:Transmission of respiratory viruses: from basic science to evidence based options for control
Investigator(s):Peiris JSM
Department:School of Public Health
Source(s) of Funding:Croucher Foundation - Conference / Seminars
Start Date:06/2017


Project Title:Investigation on the immunological cross-protection between different human coronaviruses
Investigator(s):Peiris JSM, Poon LML, Mok KP
Department:School of Public Health
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2019




Researcher : Poon KM

List of Research Outputs

Chu H., Chan C.M., Zhang X., Wang Y., Yuan S., Zhou J., Au Yeung K.H.R., Sze K.H., Yang D., Shuai H.V., Hou Y., Li C., Zhao X., Poon K.M., Leung A.S.P., Yeung M.L., Yan J., Lu G., Jin D., Gao G.F., Chan J.F.W. and Yuen K.Y., Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells, Journal of Biological Chemistry. 2018, 293: 11709-11726.
Guo Q., Chan J.F.W., Poon K.M., Wu S., Chan C.S., Hou L., Yip C.Y., Ren C., Cai J., Zhao M., Zhang J., Song X., Chan K.H., Wang B., Kok K.H., Wen Y., Yuen K.Y. and Chen W., Immunization With a Novel Human Type 5 Adenovirus-Vectored Vaccine Expressing the Premembrane and Envelope Proteins of Zika Virus Provides Consistent and Sterilizing Protection in Multiple Immunocompetent and Immunocompromised Animal Models, The Journal of Infectious Diseases. 2018, 218: 365-377.


Researcher : Poon LLM

Project Title:Reverse genetic for a coronavirus responsible for severe acute respiratory syndrome
Investigator(s):Poon LML, Guan Y
Department:Microbiology
Source(s) of Funding:VCO SARS Research Fund
Start Date:07/2003


Project Title:International Conference on Options for Control of Influenza V Genetic Characterization of a Novel Coronavirus Responsible for Severe Acute Respiratory Syndrome A Coronavirus Responsible for Severe Acute Respiratory Syndrome
Investigator(s):Poon LML
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2003


Project Title:Generation of a replication-incompetent NP-knockout influenza virus that allows expression of galactose-alpha-1,3-galactose (alpha-Gal) in infected cells to enhance adaptive immune response
Investigator(s):Poon LML, Doak SAV
Department:School of Public Health
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:07/2015


Project Title:Vaccination scheme development to stimulate both B and T cell dependent heterosubtypic protection against Influenza A viruses in mice
Investigator(s):Poon LML, Doak SAV
Department:School of Public Health
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:07/2015


Project Title:Detection and characterization of antibody-dependent cell-mediated cytotoxicity (ADCC) responses against human H7N9 virus in humans and mice
Investigator(s):Poon LML, Doak SAV
Department:School of Public Health
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:05/2016
Completion Date:03/2019


Project Title:Dissecting the roles of influenza viral codon bias and CpG dinucleotide usage frequency on virus replication
Investigator(s):Poon LML
Department:School of Public Health
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2018


Project Title:Outstanding Researcher Award 2016-17
Investigator(s):Poon LML
Department:School of Public Health
Source(s) of Funding:Outstanding Researcher Award
Start Date:01/2018


Project Title:Use of next-generation sequencing to dissect the role of influenza viral polymerase activity and fidelity on virus evolution and adaptation at the single-molecule level
Investigator(s):Poon LML
Department:School of Public Health
Source(s) of Funding:Croucher Senior Research Fellowships in Natural Sciences, Technology and Medicine
Start Date:01/2018




Researcher : Poon WSR

List of Research Outputs

Rosa Duque J.A.I.M.E. .S., To K.K.W., Chiang A.K.S., Chan G.C.F., Poon W.S.R., Yuen K.Y., Ha S.Y. and Cheuk D.K.L., Candida Tropicalis renal microabscesses in a child with leukemia confirmed using nucleic acid amplification and recovery after prolonged antifungal and corticosteroid treatment, International Journal of Infectious Diseases. 2019, 81: 110-113.
Wong C.Y.S., Poon W.S.R., Foo C.H., Ngan A.H.Y., Tse H., Lam C.M.V., Leung H.Y., Wong C.P., Cheng C.C.V., Chen H.K.J. and Yuen K.Y., Novel selective medium for the isolation of corynebacterium kroppenstedtii from heavily colonised clinical specimens , Journal of Clinical Pathology. 2018, 71: 781-786.
Zhu H., Lee C.Y., Li C., Mak W.N., Chen Y., Chan K.H., Zhang J., Fung W.F., Zhang R.Q., Fung Y.F., Poon W.S.R., Lam J.Y., Tam S., Hung F.N.I., Chen H., Yuen K.Y. and To K.K.W., Low population serum microneutralization antibody titer against the predominating influenza A(H3N2) N121K virus during the severe influenza summer peak of Hong Kong in 2017, Emerging Microbes & Infections. New York, NPG, 2018, 7: 23.


Researcher : Shuai HV

List of Research Outputs

Chu H., Chan C.M., Zhang X., Wang Y., Yuan S., Zhou J., Au Yeung K.H.R., Sze K.H., Yang D., Shuai H.V., Hou Y., Li C., Zhao X., Poon K.M., Leung A.S.P., Yeung M.L., Yan J., Lu G., Jin D., Gao G.F., Chan J.F.W. and Yuen K.Y., Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells, Journal of Biological Chemistry. 2018, 293: 11709-11726.
Yan B., Chu H., Yang D., Sze K.H., Lai P.M., Yuan S., Shuai H.V., Wang Y., Kao R.Y.T., Chan J.F.W. and Yuen K.Y., Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication, Viruses. 2019, 11: 73.
Zhang K., Li C., Luo Y.S., Wen L.R., Yuan S., Wang D., WONG H.Y.B., Zhao X., Chiu M.C., Ye Z., Sun Z., Zhao H., ZHANG X., Hu M., Yang D., Shuai H.V., Wang Y., He J., Bose M.E., Henrickson K.J., Huang J., Zheng B., Chu H. and Zhou J., Establishment of a lethal aged mouse model of human respiratory syncytial virus infection, Antiviral Research. 2019, 161: 125-133.
Zhao H., To K.K.W., Chu H., Ding Q., Zhao X., Li C., Shuai H.V., Yuan S., Zhou J., Kok K.H., Jiang S. and Yuen K.Y., Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza, Nature Communications. 2018, 9.


Researcher : Siu GKH

List of Research Outputs

TAM K.G.K., Leung S.S., Siu G.K.H., CHANG K.C., Wong S.S.Y., Ho P.L., Leung K.C. and Yam W.C., Direct detection of pyrazinamide resistance in Mycobacterium tuberculosis by use of pncA PCR sequencing. , Journal of Clinical Microbiology. American Society of Microbiology, 2019, 57.


Researcher : Smith GJ

Project Title:Research into the ecology, evolution and population genetics of influenza A (H5N1) virus
Investigator(s):Smith GJ
Department:Microbiology
Source(s) of Funding:National Institutes of Health, US Department of Health and Human Services - General Award
Start Date:05/2007


Project Title:Outstanding Young Researcher Award 2008-2009
Investigator(s):Smith GJ
Department:Microbiology
Source(s) of Funding:Outstanding Young Researcher Award
Start Date:12/2009




Researcher : Song W

List of Research Outputs

Wang P., Song W., Mok B.W.Y., Zheng M., Lau S.Y.P., Liu S., CHEN P., Huang X., LIU H., CREMIN C.J. and Chen H., The PB2 Polymerase Host Adaptation Substitutions Prime Avian Indonesia Sub Clade 2.1 H5N1 Viruses for Infecting Humans, Viruses. Switerland, MDPI, 2019, 11: 292.
Wu H., Sun N., Song W., Zhu L., Chen H. and Cai Z., Identification of different hemagglutinin isoforms of influenza A virus H1N1, Rapid Communications in Mass Spectrometry. Chichester, John Wiley And Sons Ltd, 2018, 32: 1372-1378.


Researcher : Sridhar S

Project Title:Clinical and virological features of chronic hepatitis E due to genotype 4 hepatitis E virus in immunocompromised patients
Investigator(s):Sridhar S, Chan JFW, Lau SKP, Woo PCY, Yuen KY
Department:Microbiology
Source(s) of Funding:Seed Fund for Basic Research for New Staff
Start Date:09/2017


Project Title:Clinical Virology Symposium ; Prevalence of human hepegivirus-1 in hepatitis C infected individuals, Hong Kong
Investigator(s):Sridhar S
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:05/2019
Completion Date:05/2019


Project Title:Markers of hepatitis E infection among hepatitis C infected persons in Hong Kong
Investigator(s):Sridhar S
Department:Microbiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2019


List of Research Outputs

Cheng C.C.V., Wong S.C., Wong C.Y.S., Sridhar S., Yip C.Y., Chen H.K.J., Fung J., Chiu H.Y.K., Ho P.L., Chen S., Cheng B.W.C., Ho C.L., Lo C.M. and Yuen K.Y., Nosocomial transmission of hepatitis C virus in a liver transplant center in Hong Kong: implication of reusable blood collection tube holder as the vehicle for transmission, Infection Control & Hospital Epidemiology. 2018, 39: 1170-1177.
Cheng C.C.V., Wong S.C., Wong C.Y.S., Sridhar S., Yip C.Y., Chen H.K.J., Fung J., Chiu H.Y.K., Ho P.L., Chen S., Cheng B.W.C., Ho S.L., Lo C.M. and Yuen K.Y., Reusable blood collection tube holders are implicated in nosocomial hepatitis C virus transmission, Infection Control & Hospital Epidemiology. 2019, 40: 252-253.
Cheng C.C.V., Wong S.C., Cao H., Chen J.H.K., So S.Y.C., Wong S.C.Y., Sridhar S., Yuen K.Y. and Ho P.L., Whole-genome sequencing data-based modeling for the investigation of an outbreak of community-associated methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit in Hong Kong, European Journal of Clinical Microbiology & Infectious Diseases. 2019, 38: 563-573.
Lau S.K.P., ZHAO S., Sridhar S., Yip C.Y., AW YONG K.L., Chow E.Y.Y., Cheung K.C.M., Hui R.W.H., Leung R.Y.H., Lai S.K., Wu A.K.L., To K.K.W., Woo P.C.Y. and Yuen K.Y., Molecular epidemiology of coxsackievirus A6 circulating in Hong Kong reveals common neurological manifestations and emergence of novel recombinant groups, Journal of Clinical Virology. 2018, 108: 43-49.
Sridhar S., Cheng C.C.V., Wong S.C., Yip C.Y., Wu S., Lo A.W.I., Leung K.H., Mak W.N., Cai J., Li X., Chan J.F.W., Lau S.K.P., Woo P.C.Y., Lai W.M., Kwan T.H., Au T.W.K., Lo C.M., Wong C.Y.S. and Yuen K.Y., Donor-Derived Genotype 4 Hepatitis E Virus Infection, Hong Kong, China, 2018, Emerging Infectious Diseases. 2019, 25: 425-433.
Sridhar S., Chung T.W.H., Chan J.F.W., Cheng C.C.V., Lau S.K.P., Yuen K.Y. and Woo P.C.Y., Emergence of Cytomegalovirus Mononucleosis Syndrome Among Young Adults in Hong Kong Linked to Falling Seroprevalence: Results of a 14-Year Seroepidemiological Study, Open Forum Infectious Diseases. 2018, 5.
Sridhar S., Hepatitis E: an emerging virus , HA Infectious Diseases Center Medical Infectious Disease Week 2019. 2019.
Sridhar S., Wu S. and Chew N.F.S., Prevalence Of Human Hepegivirus - 1 In Hepatitis C Infected Individuals, Hong Kong , Clinical Virology Symposium . 2019.
Sridhar S., Yip C.Y., Wu S., Cai J., Zhang J., Leung K.H., Chung T.W.H., Chan J.F.W., Chan W.M., Teng L.L., Au-Yeung R.K.H., Cheng C.C.V., Chen H., Lau S.K.P., Woo P.C.Y., Xia N.S., Lo C.M. and Yuen K.Y., Rat Hepatitis E Virus as Cause of Persistent Hepatitis after Liver Transplant, Emerging Infectious Diseases. 2018, 24: 2241-2250.
Sridhar S., Wu S. and Woo P.C.Y., SEROLOGICAL SUSCEPTIBILITY OF IMMUNOCOMPROMISED TRANSPLANT RECIPIENTS TO HEPATITIS E INFECTION IN HONG KONG: A HEPATITIS E VIRUS GENOTYPE 4 ENDEMIC REGION, 17th Asia-Pacific Congress of Clinical Microbiology and Infection . 2018.
Sridhar S., Transfusion transmission of vector-borne flaviviruses, International Plasma Fractionation Association Workshop . 2019.
Wang L., Teng L.L., Lau S.K.P., Sridhar S., Fu H., Gong W., Li M., Xu Q., He Y., Zhuang H., Woo P.C.Y. and Wang L., Transmission of a Novel Genotype of Hepatitis E Virus from Bactrian Camels to Cynomolgus Macaques, Journal of Virology. 2019, 93.
Wong S.S.Y., Yip C.Y., Sridhar S., Leung K.H., Cheng A.K.W., Fung A.M.Y., Lam H.Y., Chan K.H., Chan J.F.W., Cheng C.C.V., Tang B.S.F. and Yuen K.Y., Comparative evaluation of a laboratory-developed real-time PCR assay and RealStar® Adenovirus PCR Kit for quantitative detection of human adenovirus, Virology Journal. 2018, 15.
Zhang J., Kang J., Dehghan S., Sridhar S., Lau S.K.P., Ou J., Woo P.C.Y., Zhang Q. and Seto D., A survey of recent adenoviral respiratory pathogens in Hong Kong reveals emergent and recombinant human adenovirus type 4 (HAdV-E4) circulating in civilian populations, Viruses. 2019, 11(2): 129.
Zhou P.S.H., Yip C.Y., Sridhar S., Chow W.N., To K.K.W., Chan K.H., Chan J.F.W., Cheng C.C.V., Yuen K.Y., Woo P.C.Y. and Lau S.K.P., Identification And Characteristics Of The Newly Emerged Subclades Of Enterovirus D68 Associated With Severe Respiratory/central Nervous System Infections In Hong Kong. Australia Society For Microbiology Annual Scientific Meeting 2018, (Brisbane, Australia). 2018.


Researcher : Sun Z

List of Research Outputs

Zhang K., Li C., Luo Y.S., Wen L.R., Yuan S., Wang D., WONG H.Y.B., Zhao X., Chiu M.C., Ye Z., Sun Z., Zhao H., ZHANG X., Hu M., Yang D., Shuai H.V., Wang Y., He J., Bose M.E., Henrickson K.J., Huang J., Zheng B., Chu H. and Zhou J., Establishment of a lethal aged mouse model of human respiratory syncytial virus infection, Antiviral Research. 2019, 161: 125-133.


Researcher : Sze KH

Project Title:XXIInd International Conference on Magnetic Resonance in Biological Systems (ICMRBS 2006) Backbone Dynamics and Solution Structure of a Thermophilic Acylphosphatase from Pyrococcus Horikoshii by NMR Spectroscopy
Investigator(s):Sze KH
Department:Chemistry
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:08/2006


Project Title:System Biology investigation on virulence factors of methicillin-resistant Staphylococcus aureus (MRSA)
Investigator(s):Sze KH, Yuen KY, Kao RYT
Department:Microbiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:03/2015


Project Title:Host target characterizations for early secreted virulence factors ESAT6/CFP10 of Mycobacterium tuberculosis and structure-based screening of ESAT6/CFP10 's inhibitors for combating multi-drug resistant tuberculosis (MDR-TB)
Investigator(s):Sze KH, Kao RYT
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:07/2015


Project Title:Structure and function Investigation of pro-inflammatory lipid binding virulence factor of pathogenic Talaromyces marneffei
Investigator(s):Sze KH, Yuen KY, Kao RYT
Department:Microbiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:02/2017
Completion Date:01/2019


List of Research Outputs

Chu H., Chan C.M., Zhang X., Wang Y., Yuan S., Zhou J., Au Yeung K.H.R., Sze K.H., Yang D., Shuai H.V., Hou Y., Li C., Zhao X., Poon K.M., Leung A.S.P., Yeung M.L., Yan J., Lu G., Jin D., Gao G.F., Chan J.F.W. and Yuen K.Y., Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells, Journal of Biological Chemistry. 2018, 293: 11709-11726.
Lam W.H., Sze K.H., Ke Y., Tse M.K., Zhang H., Woo P.C.Y., Lau S.K.P., Lau C.C.Y., Xu S., Lai P.M., Zhou T., Antonyuk S.V., Kao R.Y.T., Yuen K.Y. and Hao Q., Talaromyces marneffei Mp1 Protein, a Novel Virulence Factor, Carries Two Arachidonic Acid-Binding Domains To Suppress Inflammatory Responses in Hosts , Infection and Immunity. 2019, 87.
Yan B., Chu H., Yang D., Sze K.H., Lai P.M., Yuan S., Shuai H.V., Wang Y., Kao R.Y.T., Chan J.F.W. and Yuen K.Y., Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication, Viruses. 2019, 11: 73.


Researcher : TAM KGK

List of Research Outputs

TAM K.G.K., Leung S.S., Siu G.K.H., CHANG K.C., Wong S.S.Y., Ho P.L., Leung K.C. and Yam W.C., Direct detection of pyrazinamide resistance in Mycobacterium tuberculosis by use of pncA PCR sequencing. , Journal of Clinical Microbiology. American Society of Microbiology, 2019, 57.


Researcher : TAN YP

List of Research Outputs

Lau S.K.P., Xing F., Tsang C.C., TANG Y.M., TAN Y.P., Ye H., Lau R.W.T., Chen H.K.J., Lo S.K.F. and Woo P.C.Y., Clinical characteristics, rapid identification, molecular epidemiology and antifungal susceptibilities of Talaromyces marneffei infections in Shenzhen, China, Mycoses. 2019, 62: 450-457.


Researcher : TANG J

List of Research Outputs

LIU W., Wong Y.C., CHEN S.M.Y., TANG J., Wang H., Cheung K.L.A. and Chen Z., DNA prime/MVTT boost regimen with HIV-1 mosaic Gag enhances the potency of antigen-specific immune responses, Vaccine. 2018, 36: 4621-4632.
TANG J., Tan Z. and Chen Z., In vivo electroporation of a codon-optimized BERopt DNA vaccine protects mice from pathogenic Mycobacterium tuberculosis aerosol challenge, Tuberculosis. 2018, 113: 65-75.


Researcher : TANG YM

List of Research Outputs

Lau S.K.P., Xing F., Tsang C.C., TANG Y.M., TAN Y.P., Ye H., Lau R.W.T., Chen H.K.J., Lo S.K.F. and Woo P.C.Y., Clinical characteristics, rapid identification, molecular epidemiology and antifungal susceptibilities of Talaromyces marneffei infections in Shenzhen, China, Mycoses. 2019, 62: 450-457.
Tsang C.C., TANG Y.M., CHAN K.F., Lee C.Y., Chan J.F.W., Ngan A.H.Y., Cheung M., Lau E.C.L., Li X., Ng R.H.Y., Lai C.K.C., Fung S.C.K., Lau S.K.P. and Woo P.C.Y., Diversity of phenotypically non-dermatophyte, non-Aspergillus filamentous fungi causing nail infections: importance of accurate identification and antifungal susceptibility testing, Emerging Microbes & Infections. 2019, 8: 531-541.
Tsang C.C., TANG Y.M., FONG Y.H., Kinne J., LEE H.H., Joseph M., Jose S., Schuster R.K., Tang Y., Sivakumar S., Chen H.K.J., Teng L.L., Lau S.K.P., Wernery U. and Woo P.C.Y., Ignatzschineria cameli sp. nov., isolated from necrotic foot tissue of dromedaries (Camelus dromedarius) and associated maggots (Wohlfahrtia species) in Dubai, International Journal of Systematic and Evolutionary Microbiology. 2018, 68: 3627-3634.


Researcher : TONG MK

List of Research Outputs

Wang Y.L., TONG M.K., Chow K.H., Cheng C.C.V., TSE C.W., Wu K.L.A., LAI R.W., Luk W.K., Tsang D.N.C. and Ho P.L., Occurrence of Highly Conjugative IncX3 Epidemic Plasmid Carrying blaNDM in Enterobacteriaceae Isolates in Geographically Widespread Areas, Frontiers in Microbiology. 2018, 9.


Researcher : TONG S

List of Research Outputs

Xu Y.J., Zhou R., Zong J.F., Lin W.S., TONG S., Guo Q.J., Lin C., Lin S.J., Chen Y.X., Chen M.R., Chen H., Ye Y.B. and Pan J.J., Epstein-Barr virus-coded miR-BART13 promotes nasopharyngeal carcinoma cell growth and metastasis via targeting of the NKIRAS2/NF-κB pathway, Cancer Letters. Iceland, Amsterdam, Elsevier/North-Holland, 2019, 447: 33-40.


Researcher : TSANG OL

List of Research Outputs

Chan J.F.W., TSANG O.L., ZOU Z., CHIK K.K.H., Yuan S., Chu H., Lau S.K.P. and Yuen K.Y., The Cellular Kinase Inhibitor OSU-03012 Inhibits Enterovirus 71 In Vitro, Annual Meeting of the Infectious Diseases Society of America, IDWeek 2018.


Researcher : Tan Z

Project Title:Role of Δ42PD1/TLR4 interaction in human hepatocellular carcinoma and its blockade as a novel immunotherapy strategy
Investigator(s):Tan Z, Chen Z
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:06/2016
Completion Date:04/2019


Project Title:Combination of dendritic cell-based vaccination and immune checkpoint blockade for malignant mesothelioma immunotherapy
Investigator(s):Tan Z, Chen Z
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:06/2017


Project Title:Augmenting antitumor T responses of viral cancer therapy by targeting myeloid-derived suppressor cells with an armed recombinant vaccinia virus
Investigator(s):Tan Z, Chen Z
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:09/2018


List of Research Outputs

TANG J., Tan Z. and Chen Z., In vivo electroporation of a codon-optimized BERopt DNA vaccine protects mice from pathogenic Mycobacterium tuberculosis aerosol challenge, Tuberculosis. 2018, 113: 65-75.
Tan Z., Liu L., Chiu M.S., Cheung K.W., Yan C.W., Yu Z., LEE B.K., LIU W., Man K. and Chen Z., Virotherapy-recruited PMN-MDSC infiltration of mesothelioma blocks antitumor CTL by IL-10-mediated dendritic cell suppression, OncoImmunology. 2019, 8: e1518672.


Researcher : Tang HY

List of Research Outputs

Liu L., Wei Q., Lin Q., Fang J., Wang H., Kwok H.Y., Tang H.Y., Nishiura K., Peng J., Wu T., Wu T., Cheung K.W., Chan K.H., Alvarez X., Qin C., Lackner A., Perlman S., Yuen K.Y. and Chen Z., Anti–spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection, JCI Insight. 2019, 4.


Researcher : Tang Y

List of Research Outputs

Teng L.L., Tang Y., Wong S.S.Y., Fong Y.H., Zhao Z.H.E., Wong C.P., Chen H.K.J., Ngan A.K.L., Wu K.L.A., Fung S.C.K., Que T.L., Lau S.K.P. and Woo P.C.Y., Maldi-tof Ms For Identification Of Tsukamurella Species: Tsukamurella Tyrosinosolvens As The Predominant Species Associated With Ocular Infections, Emerging Microbes & Infections. 2018, 7.
Tsang C.C., TANG Y.M., FONG Y.H., Kinne J., LEE H.H., Joseph M., Jose S., Schuster R.K., Tang Y., Sivakumar S., Chen H.K.J., Teng L.L., Lau S.K.P., Wernery U. and Woo P.C.Y., Ignatzschineria cameli sp. nov., isolated from necrotic foot tissue of dromedaries (Camelus dromedarius) and associated maggots (Wohlfahrtia species) in Dubai, International Journal of Systematic and Evolutionary Microbiology. 2018, 68: 3627-3634.


Researcher : Tang YMJ

List of Research Outputs

Wernery U., Tsang C.C., Hebel C., Damerau A., Kinne J., Cai J., Küspert H., Chan K.F., Joseph M., XUE S., Raghavan R., Tang Y.M.J., Syriac G., Lau S.K.P., Jose S. and Woo P.C.Y., Serodiagnosis of aspergillosis in falcons (Falco spp.) by an Afmp1p-based enzyme-linked immunosorbent assay, Mycoses. Blackwell Verlag GmbH, 2018, 61: 600-609.


Researcher : Tee KM

List of Research Outputs

Chan J.F.W., Yuan S., CHIK K.K.H., Yip C.Y., Tee K.M., Lai K.K., Kao R.Y.T. and Yuen K.Y., Repurposing novobiocin as a flavivirus protease inhibitor, 67th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2018). 2018.


Researcher : Teng LL

Project Title:Usefulness of full sequence and 5' end 527-bp 16S ribosomal RNA gene sequencing for identification of medically important aerobic Gram-positive cocci
Investigator(s):Teng LL, Woo PCY, Lau SKP, Yuen KY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:09/2006


List of Research Outputs

Churgin S.M., Teng L.L., Ho J.H.P., Graydon R., Martelli P., Lee F.K., Hui S.W., Fong J.Y.H., Lau S.K.P. and Woo P.C.Y., First case report of fatal Nocardia nova infection in yellow-bibbed lory (Lorius chlorocercus) identified by multilocus sequencing, BMC Veterinary Research. 2019, 15: 4.
Guan T.P., Teng L.L., Yeong K.Y., You Z.Q., Liu H., Wong S.S.Y., Lau S.K.P. and Woo P.C.Y., Metagenomic Analysis Of Sichuan Takin Fecal Sample Viromes Reveals Novel Enterovirus And Astrovirus, Virology. 2018, 521: 77-91.
Lau S.K.P., Wong A.C.P., Zhang L., Luk H.K.H., Kwok J.S.L., Ahmed S.S., Cai J., Zhao P.S.H., Teng L.L., Tsui S.K.W., Yuen K.Y. and Woo P.C.Y., Novel Bat Alphacoronaviruses in Southern China Support Chinese Horseshoe Bats as an Important Reservoir for Potential Novel Coronaviruses, Viruses. 2019, 11: 423.
Sridhar S., Yip C.Y., Wu S., Cai J., Zhang J., Leung K.H., Chung T.W.H., Chan J.F.W., Chan W.M., Teng L.L., Au-Yeung R.K.H., Cheng C.C.V., Chen H., Lau S.K.P., Woo P.C.Y., Xia N.S., Lo C.M. and Yuen K.Y., Rat Hepatitis E Virus as Cause of Persistent Hepatitis after Liver Transplant, Emerging Infectious Diseases. 2018, 24: 2241-2250.
Teng L.L., Tang Y., Wong S.S.Y., Fong Y.H., Zhao Z.H.E., Wong C.P., Chen H.K.J., Ngan A.K.L., Wu K.L.A., Fung S.C.K., Que T.L., Lau S.K.P. and Woo P.C.Y., Maldi-tof Ms For Identification Of Tsukamurella Species: Tsukamurella Tyrosinosolvens As The Predominant Species Associated With Ocular Infections, Emerging Microbes & Infections. 2018, 7.
Tsang C.C., TANG Y.M., FONG Y.H., Kinne J., LEE H.H., Joseph M., Jose S., Schuster R.K., Tang Y., Sivakumar S., Chen H.K.J., Teng L.L., Lau S.K.P., Wernery U. and Woo P.C.Y., Ignatzschineria cameli sp. nov., isolated from necrotic foot tissue of dromedaries (Camelus dromedarius) and associated maggots (Wohlfahrtia species) in Dubai, International Journal of Systematic and Evolutionary Microbiology. 2018, 68: 3627-3634.
Wang L., Teng L.L., Lau S.K.P., Sridhar S., Fu H., Gong W., Li M., Xu Q., He Y., Zhuang H., Woo P.C.Y. and Wang L., Transmission of a Novel Genotype of Hepatitis E Virus from Bactrian Camels to Cynomolgus Macaques, Journal of Virology. 2019, 93.
Woo P.C.Y., Teng L.L., Bai R., Tang Y., Wong A.Y.P., Li K.S.M., Lam C.S.F., Fan R.Y.Y., Lau S.K.P. and Yuen K.Y., Novel Picobirnaviruses in Respiratory and Alimentary Tracts of Cattle and Monkeys with Large Intra- and Inter-Host Diversity, Viruses. 2019, 11: 574.
Yeung M.L., JIA L., Yip C.Y., Chan J.F.W., Teng L.L., Chan K.H., Cai J., ZHANG C., Zhang J., Wong L.W.M., Kok K.H., Lau S.K.P., Woo P.C.Y., Lo J.Y.C., Jin D., Shih S.R. and Yuen K.Y., Human tryptophanyl-tRNA synthetase is an IFN-γ–inducible entry factor for Enterovirus, Journal of Clinical Investigation. 2018, 128: 5163-5177.


Researcher : To KKW

Project Title:Rapid detection of macrolide resistance amony Mycoplasma pneumoniae in Queen Mary Hospital
Investigator(s):To KKW, Ho PL, Chan KH, Hung FNI, Chiu SSS
Department:Microbiology
Source(s) of Funding:Queen Mary Hospital Charitable Trust - Training and Research Assistance Scheme
Start Date:07/2011


Project Title:Serological study of H7N9, H5N1 and H9N2 influenza among animal handlers
Investigator(s):To KKW, Hung FNI, Yuen KY, Chan JFW
Department:Microbiology
Source(s) of Funding:Centre for Health Protection
Start Date:09/2013


Project Title:Serological study of H7N9, H5N1 and H9N2 influenza among animal handlers (CHP-PH-11)
Investigator(s):To KKW
Department:Microbiology
Source(s) of Funding:Commissioned Project: Health and Medical Research Fund
Start Date:10/2013


Project Title:Rapid Molecular Diagnosis for Hospitalized Patients with Respiratory Tract Infection
Investigator(s):To KKW, Hung FNI
Department:Microbiology
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:03/2018


Project Title:29th ECCMID; Improving the detection of respiratory virus in saliva specimens by centrifugation
Investigator(s):To KKW
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:04/2019
Completion Date:04/2019


List of Research Outputs

Bao S., Jia L., Zhou X., ZHANG Z., Wu W.L., Yu Z., NG G.C.T., Fan Y., Wong S.M., Huang S., To K.K.W., Yuen K.Y., Yeung M.L. and Song Y., Integrated analysis of mRNA-seq and miRNA-seq for host susceptibilities to influenza A (H7N9) infection in inbred mouse lines, Functional & Integrative Genomics. 2018, 18: 411-424.
Chan J.F.W., Yuan S., Chu H., Ye Z., Wen L.R., Yan B., To K.K.W., Kao R.Y.T. and Yuen K.Y., Best Poster Award (1st place in the Young Investigator Category), The 32nd International Conference on Antiviral Research (ICAR 2019). 2019.
Chan J.F.W., Yuan S., Chu H., Ye Z., WEN L., Yan B., To K.K.W., Kao R.Y.T. and Yuen K.Y., Identification of Sterol Regulatory Element Binding Protein-Dependent Lipidomic Reprogramming as a Broad-Spectrum Antiviral Target, 32nd International Conference on Antiviral Research (ICAR). 2019.
LING L., Wu T., To K.K.W., Cheung K.W., Lui K.O., NIU M., LAM K.S., Wang C.C., Li J., Wang H., Yuen K.Y. and Chen Z., Vedolizumab-mediated integrin α4β7 blockade does not control HIV-1SF162 rebound after combination antiretroviral therapy interruption in humanized mice, AIDS. 2019, 33: F1-F12.
Lau S.K.P., ZHAO S., Sridhar S., Yip C.Y., AW YONG K.L., Chow E.Y.Y., Cheung K.C.M., Hui R.W.H., Leung R.Y.H., Lai S.K., Wu A.K.L., To K.K.W., Woo P.C.Y. and Yuen K.Y., Molecular epidemiology of coxsackievirus A6 circulating in Hong Kong reveals common neurological manifestations and emergence of novel recombinant groups, Journal of Clinical Virology. 2018, 108: 43-49.
Lee C.Y., Zhang J., Chu H., Li C., Zhu H., Mak W.W.N., Chen Y., Kok K.H., To K.K.W. and Yuen K.Y., H7N9 influenza A virus activation of necroptosis in human monocytes links innate and adaptive immune responses, Cell Death & Disease. 2019, 10.
Li C., To K.K.W., Zhang J., Lee C.Y., Zhu H., Mak W.N., Hung F.N.I. and Yuen K.Y., Co-stimulation With TLR7 Agonist Imiquimod and Inactivated Influenza Virus Particles Promotes Mouse B Cell Activation, Differentiation, and Accelerated Antigen Specific Antibody Production., Frontiers in Immunology. 2018, 9.
Lui W.Y., Yuen C.K., Li C., Wong W.M., Lui P.Y., Lin C.H., Chan K.H., Zhao H., Chen H., To K.K.W., Zhang J., Yuen K.Y. and Kok K.H., SMRT sequencing revealed the diversity and characteristics of defective interfering RNAs in influenza A (H7N9) virus infection, Emerging Microbes & Infections. 2019, 8: 662-674.
Rosa Duque J.A.I.M.E. .S., To K.K.W., Chiang A.K.S., Chan G.C.F., Poon W.S.R., Yuen K.Y., Ha S.Y. and Cheuk D.K.L., Candida Tropicalis renal microabscesses in a child with leukemia confirmed using nucleic acid amplification and recovery after prolonged antifungal and corticosteroid treatment, International Journal of Infectious Diseases. 2019, 81: 110-113.
Seto T.Y.M., Ko K.Y.J., Cheung K.W., To K.K.W., Hui P.W., Lao T.H.T. and Lee C.P., The Accuracy of Self-Screening of Group B Streptococcus in Pregnant Women—A Randomized Crossover Study, Journal of Obstetrics and Gynaecology Canada. 2019, 41: 792-797.
To K.K.W., Chan K.H., Ho J., Pang P.K.P., Ho D.T.Y., Chang A.C.H., Seng C.W., Yip C.C.Y., Cheng C.C.V., Hung F.N.I. and Yuen K.Y., Respiratory virus infection among hospitalized adult patients with or without clinically apparent respiratory infection: a prospective cohort study, Clinical Microbiology and Infection. 2019.
To K.K.W., Topic Editor, Frontiers in Medicine; Frontiers in Immunology; Frontiers in Microbiology. 2018.
Zhang J., ZHU H., Chen Y., LI C., Li C., Gozali L., Lee C.Y., To K.K.W., Hung F.N.I. and Yuen K.Y., Prostaglandin E2-mediated impairment of innate immune response to A(H1N1)pdm09 infection in diet-induced obese mice could be restored by paracetamol , Journal of Infectious Diseases. 2018.
Zhao H., To K.K.W., Chu H., Ding Q., Zhao X., Li C., Shuai H.V., Yuan S., Zhou J., Kok K.H., Jiang S. and Yuen K.Y., Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza, Nature Communications. 2018, 9.
Zhou P.S.H., Yip C.Y., Sridhar S., Chow W.N., To K.K.W., Chan K.H., Chan J.F.W., Cheng C.C.V., Yuen K.Y., Woo P.C.Y. and Lau S.K.P., Identification And Characteristics Of The Newly Emerged Subclades Of Enterovirus D68 Associated With Severe Respiratory/central Nervous System Infections In Hong Kong. Australia Society For Microbiology Annual Scientific Meeting 2018, (Brisbane, Australia). 2018.
Zhu H., Lee C.Y., Li C., Mak W.N., Chen Y., Chan K.H., Zhang J., Fung W.F., Zhang R.Q., Fung Y.F., Poon W.S.R., Lam J.Y., Tam S., Hung F.N.I., Chen H., Yuen K.Y. and To K.K.W., Low population serum microneutralization antibody titer against the predominating influenza A(H3N2) N121K virus during the severe influenza summer peak of Hong Kong in 2017, Emerging Microbes & Infections. New York, NPG, 2018, 7: 23.


Researcher : To WCS

Project Title:Pharmacogenomic and molecular epidemiological study of HIV/AIDS patients co-infected with Hepatitis C virus (HCV)
Investigator(s):To WCS, Yam WC
Department:Microbiology
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:10/2015


Project Title:Latent proviral DNA reservoir as a target for HIV-1 genotypic resistance and tropism analyses amoung HIV-1 patients with viremia or suppressed viral load
Investigator(s):To WCS, Yam WC
Department:Microbiology
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:10/2016




Researcher : Tsang CC

Project Title:20th Congress of the International Society for Human and Animal Mycology; Serodiagnosis of aspergillosis in falcons (Falco spp.) by Afmp1p-based enzyme-linked immunosorbent assay
Investigator(s):Tsang CC
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2018
Completion Date:07/2018


List of Research Outputs

Lau S.K.P., Xing F., Tsang C.C., TANG Y.M., TAN Y.P., Ye H., Lau R.W.T., Chen H.K.J., Lo S.K.F. and Woo P.C.Y., Clinical characteristics, rapid identification, molecular epidemiology and antifungal susceptibilities of Talaromyces marneffei infections in Shenzhen, China, Mycoses. 2019, 62: 450-457.
Lau S.K.P., Wong Y.M., Tsang C.C., Ahmed S.S., Au Yeung K.H.R., Yuen K.Y., Wernery U. and Woo P.C.Y., Discovery and sequence analysis of four deltacoronaviruses from birds in the Middle East reveal interspecies jumping with recombination as a potential mechanism for avian-to-avian and avian-to-mammalian transmission, Journal of Virology. 2018, 92: e00265-18.
Meyer W., Irinyi L., Hoang M.T.V., Robert V., Garcia-Hermoso D., Desnos-Ollivier M., Yurayart C., Tsang C.C., Lee C.Y., Woo P.C.Y., Pchelin I.M., Uhrlaß S., Nenoff P., Chindamporn A., Chen S., Hebert P.D.N. and Sorrell T.C., Database establishment for the secondary fungal DNA barcode -Translational Elongation Factor 1α (TEF1α), Genome. Canadian Science Publishing, 2019, 62: 160-169.
Tsang C.C., TANG Y.M., CHAN K.F., Lee C.Y., Chan J.F.W., Ngan A.H.Y., Cheung M., Lau E.C.L., Li X., Ng R.H.Y., Lai C.K.C., Fung S.C.K., Lau S.K.P. and Woo P.C.Y., Diversity of phenotypically non-dermatophyte, non-Aspergillus filamentous fungi causing nail infections: importance of accurate identification and antifungal susceptibility testing, Emerging Microbes & Infections. 2019, 8: 531-541.
Tsang C.C., TANG Y.M., FONG Y.H., Kinne J., LEE H.H., Joseph M., Jose S., Schuster R.K., Tang Y., Sivakumar S., Chen H.K.J., Teng L.L., Lau S.K.P., Wernery U. and Woo P.C.Y., Ignatzschineria cameli sp. nov., isolated from necrotic foot tissue of dromedaries (Camelus dromedarius) and associated maggots (Wohlfahrtia species) in Dubai, International Journal of Systematic and Evolutionary Microbiology. 2018, 68: 3627-3634.
Wernery U., Tsang C.C., Hebel C., Damerau A., Kinne J., Cai J., Küspert H., Chan K.F., Joseph M., XUE S., Raghavan R., Tang Y.M.J., Syriac G., Lau S.K.P., Jose S. and Woo P.C.Y., Serodiagnosis of aspergillosis in falcons (Falco spp.) by an Afmp1p-based enzyme-linked immunosorbent assay, Mycoses. Blackwell Verlag GmbH, 2018, 61: 600-609.
Zhao Y., Tsang C.C., Xiao M., Chan J.F.W., Lau S.K.P., Kong F., Xu Y. and Woo P.C.Y., Yeast identification by sequencing, biochemical kits, MALDI–TOF MS and rep-PCR DNA fingerprinting, Yeast identification by sequencing, biochemical kits, MALDI–TOF MS and rep-PCR DNA fingerprinting. 2018, 56: 816–827.


Researcher : Tsang DNC

List of Research Outputs

Wang Y.L., TONG M.K., Chow K.H., Cheng C.C.V., TSE C.W., Wu K.L.A., LAI R.W., Luk W.K., Tsang D.N.C. and Ho P.L., Occurrence of Highly Conjugative IncX3 Epidemic Plasmid Carrying blaNDM in Enterobacteriaceae Isolates in Geographically Widespread Areas, Frontiers in Microbiology. 2018, 9.


Researcher : Tse H

List of Research Outputs

Wong C.Y.S., Poon W.S.R., Foo C.H., Ngan A.H.Y., Tse H., Lam C.M.V., Leung H.Y., Wong C.P., Cheng C.C.V., Chen H.K.J. and Yuen K.Y., Novel selective medium for the isolation of corynebacterium kroppenstedtii from heavily colonised clinical specimens , Journal of Clinical Pathology. 2018, 71: 781-786.


Researcher : Verhoeven RJA

List of Research Outputs

LIU J., Mok B.W.Y., Verhoeven R.J.A. and Chen H., Study of lnc-BARTs-KDM1B epigenetic modulatory complex in maintaining Epstein-Barr Virus latency in NPC cells, 2019 Cancer Genetics and Epigenetics, April 7 - 12, 2019, Renaissance Tuscany II Ciocco in Lucca (Barga) Italy.. 2019.


Researcher : WANG D

List of Research Outputs

Wen L.R., Chu H., Wong H.Y.B., Wang D., Li C., Zhao X., Chiu M.C., Yuan S., Fan Y., Chen H., Zhou J. and Yuen K.Y., Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses, Emerging Microbes & Infections. New York, USA, NPG, 2018, 7.
ZHU Z., Chu H., WEN L., Yuan S., CHIK K.K.H., YUEN T.T., Yip C.Y., WANG D., Zhou J., Yin F., Jin D., Kok K.H., Yuen K.Y. and Chan J.F.W., Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy, International Journal of Molecular Sciences. 2019, 20: 392.
Zhang K., Li C., Luo Y.S., Wen L.R., Yuan S., Wang D., WONG H.Y.B., Zhao X., Chiu M.C., Ye Z., Sun Z., Zhao H., ZHANG X., Hu M., Yang D., Shuai H.V., Wang Y., He J., Bose M.E., Henrickson K.J., Huang J., Zheng B., Chu H. and Zhou J., Establishment of a lethal aged mouse model of human respiratory syncytial virus infection, Antiviral Research. 2019, 161: 125-133.
Zhou J., WANG D., WONG H.Y.B., Chu H. and Yuen K.Y., Identification and characterization of GLDC as host susceptibility gene to severe influenza., EMBO Molecular Medicine. 2018.


Researcher : WEN L

List of Research Outputs

Chan J.F.W., Yuan S., Chu H., Ye Z., WEN L., Yan B., To K.K.W., Kao R.Y.T. and Yuen K.Y., Identification of Sterol Regulatory Element Binding Protein-Dependent Lipidomic Reprogramming as a Broad-Spectrum Antiviral Target, 32nd International Conference on Antiviral Research (ICAR). 2019.
ZHU Z., Chu H., WEN L., Yuan S., CHIK K.K.H., YUEN T.T., Yip C.Y., WANG D., Zhou J., Yin F., Jin D., Kok K.H., Yuen K.Y. and Chan J.F.W., Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy, International Journal of Molecular Sciences. 2019, 20: 392.


Researcher : WONG HYB

List of Research Outputs

Wen L.R., Chu H., Wong H.Y.B., Wang D., Li C., Zhao X., Chiu M.C., Yuan S., Fan Y., Chen H., Zhou J. and Yuen K.Y., Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses, Emerging Microbes & Infections. New York, USA, NPG, 2018, 7.
Zhang K., Li C., Luo Y.S., Wen L.R., Yuan S., Wang D., WONG H.Y.B., Zhao X., Chiu M.C., Ye Z., Sun Z., Zhao H., ZHANG X., Hu M., Yang D., Shuai H.V., Wang Y., He J., Bose M.E., Henrickson K.J., Huang J., Zheng B., Chu H. and Zhou J., Establishment of a lethal aged mouse model of human respiratory syncytial virus infection, Antiviral Research. 2019, 161: 125-133.
Zhou J., WANG D., WONG H.Y.B., Chu H. and Yuen K.Y., Identification and characterization of GLDC as host susceptibility gene to severe influenza., EMBO Molecular Medicine. 2018.


Researcher : Wang D

List of Research Outputs

Wen L.R., Chu H., Wong H.Y.B., Wang D., Li C., Zhao X., Chiu M.C., Yuan S., Fan Y., Chen H., Zhou J. and Yuen K.Y., Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses, Emerging Microbes & Infections. New York, USA, NPG, 2018, 7.
ZHU Z., Chu H., WEN L., Yuan S., CHIK K.K.H., YUEN T.T., Yip C.Y., WANG D., Zhou J., Yin F., Jin D., Kok K.H., Yuen K.Y. and Chan J.F.W., Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy, International Journal of Molecular Sciences. 2019, 20: 392.
Zhang K., Li C., Luo Y.S., Wen L.R., Yuan S., Wang D., WONG H.Y.B., Zhao X., Chiu M.C., Ye Z., Sun Z., Zhao H., ZHANG X., Hu M., Yang D., Shuai H.V., Wang Y., He J., Bose M.E., Henrickson K.J., Huang J., Zheng B., Chu H. and Zhou J., Establishment of a lethal aged mouse model of human respiratory syncytial virus infection, Antiviral Research. 2019, 161: 125-133.
Zhou J., WANG D., WONG H.Y.B., Chu H. and Yuen K.Y., Identification and characterization of GLDC as host susceptibility gene to severe influenza., EMBO Molecular Medicine. 2018.


Researcher : Wang P

List of Research Outputs

Wang P., Song W., Mok B.W.Y., Zheng M., Lau S.Y.P., Liu S., CHEN P., Huang X., LIU H., CREMIN C.J. and Chen H., The PB2 Polymerase Host Adaptation Substitutions Prime Avian Indonesia Sub Clade 2.1 H5N1 Viruses for Infecting Humans, Viruses. Switerland, MDPI, 2019, 11: 292.


Researcher : Wang Y

List of Research Outputs

Chu H., Chan C.M., Zhang X., Wang Y., Yuan S., Zhou J., Au Yeung K.H.R., Sze K.H., Yang D., Shuai H.V., Hou Y., Li C., Zhao X., Poon K.M., Leung A.S.P., Yeung M.L., Yan J., Lu G., Jin D., Gao G.F., Chan J.F.W. and Yuen K.Y., Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells, Journal of Biological Chemistry. 2018, 293: 11709-11726.
Yan B., Chu H., Yang D., Sze K.H., Lai P.M., Yuan S., Shuai H.V., Wang Y., Kao R.Y.T., Chan J.F.W. and Yuen K.Y., Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication, Viruses. 2019, 11: 73.
Zhang K., Li C., Luo Y.S., Wen L.R., Yuan S., Wang D., WONG H.Y.B., Zhao X., Chiu M.C., Ye Z., Sun Z., Zhao H., ZHANG X., Hu M., Yang D., Shuai H.V., Wang Y., He J., Bose M.E., Henrickson K.J., Huang J., Zheng B., Chu H. and Zhou J., Establishment of a lethal aged mouse model of human respiratory syncytial virus infection, Antiviral Research. 2019, 161: 125-133.


Researcher : Wang YL

List of Research Outputs

Wang Y.L., TONG M.K., Chow K.H., Cheng C.C.V., TSE C.W., Wu K.L.A., LAI R.W., Luk W.K., Tsang D.N.C. and Ho P.L., Occurrence of Highly Conjugative IncX3 Epidemic Plasmid Carrying blaNDM in Enterobacteriaceae Isolates in Geographically Widespread Areas, Frontiers in Microbiology. 2018, 9.


Researcher : Wen LR

List of Research Outputs

Chan J.F.W., Yuan S., Chu H., Ye Z., Wen L.R., Yan B., To K.K.W., Kao R.Y.T. and Yuen K.Y., Best Poster Award (1st place in the Young Investigator Category), The 32nd International Conference on Antiviral Research (ICAR 2019). 2019.
Wen L.R., Chu H., Wong H.Y.B., Wang D., Li C., Zhao X., Chiu M.C., Yuan S., Fan Y., Chen H., Zhou J. and Yuen K.Y., Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses, Emerging Microbes & Infections. New York, USA, NPG, 2018, 7.
Zhang K., Li C., Luo Y.S., Wen L.R., Yuan S., Wang D., WONG H.Y.B., Zhao X., Chiu M.C., Ye Z., Sun Z., Zhao H., ZHANG X., Hu M., Yang D., Shuai H.V., Wang Y., He J., Bose M.E., Henrickson K.J., Huang J., Zheng B., Chu H. and Zhou J., Establishment of a lethal aged mouse model of human respiratory syncytial virus infection, Antiviral Research. 2019, 161: 125-133.


Researcher : Wong CP

List of Research Outputs

Teng L.L., Tang Y., Wong S.S.Y., Fong Y.H., Zhao Z.H.E., Wong C.P., Chen H.K.J., Ngan A.K.L., Wu K.L.A., Fung S.C.K., Que T.L., Lau S.K.P. and Woo P.C.Y., Maldi-tof Ms For Identification Of Tsukamurella Species: Tsukamurella Tyrosinosolvens As The Predominant Species Associated With Ocular Infections, Emerging Microbes & Infections. 2018, 7.
Wong C.P., Li X., Lau S.K.P. and Woo P.C.Y., Global Epidemiology of Bat Coronaviruses, Viruses. 2019, 11(2): 174.
Wong C.Y.S., Poon W.S.R., Foo C.H., Ngan A.H.Y., Tse H., Lam C.M.V., Leung H.Y., Wong C.P., Cheng C.C.V., Chen H.K.J. and Yuen K.Y., Novel selective medium for the isolation of corynebacterium kroppenstedtii from heavily colonised clinical specimens , Journal of Clinical Pathology. 2018, 71: 781-786.


Researcher : Wong CP

List of Research Outputs

Teng L.L., Tang Y., Wong S.S.Y., Fong Y.H., Zhao Z.H.E., Wong C.P., Chen H.K.J., Ngan A.K.L., Wu K.L.A., Fung S.C.K., Que T.L., Lau S.K.P. and Woo P.C.Y., Maldi-tof Ms For Identification Of Tsukamurella Species: Tsukamurella Tyrosinosolvens As The Predominant Species Associated With Ocular Infections, Emerging Microbes & Infections. 2018, 7.
Wong C.P., Li X., Lau S.K.P. and Woo P.C.Y., Global Epidemiology of Bat Coronaviruses, Viruses. 2019, 11(2): 174.
Wong C.Y.S., Poon W.S.R., Foo C.H., Ngan A.H.Y., Tse H., Lam C.M.V., Leung H.Y., Wong C.P., Cheng C.C.V., Chen H.K.J. and Yuen K.Y., Novel selective medium for the isolation of corynebacterium kroppenstedtii from heavily colonised clinical specimens , Journal of Clinical Pathology. 2018, 71: 781-786.


Researcher : Wong CYS

List of Research Outputs

Cao H., Wong C.Y.S., Yam W.C., LIU C., Chow K.H., Wu K.L.A. and Ho P.L., Genomic investigation of a sequence type 67 Clostridium difficile causing community-acquired fulminant colitis in Hong Kong, International Journal of Medical Microbiology. 2019.
Cheng C.C.V., Wong S.C., Wong C.Y.S., Ho P.L. and Yuen K.Y., Control of Carbapenemase-producing Enterobacteriaceae: Beyond the Hospital, EClinicalMedicine. 2018, 6: 3-4.
Cheng C.C.V., Wong S.C., Chen H.K.J., Wong C.Y.S. and Yuen K.Y., Mycobacterium chimaera -contaminated heater–cooler devices: the inner surface as the missing link?, Journal of Hospital Infection. 2018.
Cheng C.C.V., Wong S.C., Wong C.Y.S., Sridhar S., Yip C.Y., Chen H.K.J., Fung J., Chiu H.Y.K., Ho P.L., Chen S., Cheng B.W.C., Ho C.L., Lo C.M. and Yuen K.Y., Nosocomial transmission of hepatitis C virus in a liver transplant center in Hong Kong: implication of reusable blood collection tube holder as the vehicle for transmission, Infection Control & Hospital Epidemiology. 2018, 39: 1170-1177.
Cheng C.C.V., Wong S.C., Wong C.Y.S., Sridhar S., Yip C.Y., Chen H.K.J., Fung J., Chiu H.Y.K., Ho P.L., Chen S., Cheng B.W.C., Ho S.L., Lo C.M. and Yuen K.Y., Reusable blood collection tube holders are implicated in nosocomial hepatitis C virus transmission, Infection Control & Hospital Epidemiology. 2019, 40: 252-253.
Co T.H.M., Cheng C.C.V., Wei J., Wong C.Y.S., Chan S.M.S., Shek T.W.H. and Kwong A., Idiopathic granulomatous mastitis: a 10-year study from a multicentre clinical database, Pathology. 2018, 50: 742-747.
Sridhar S., Cheng C.C.V., Wong S.C., Yip C.Y., Wu S., Lo A.W.I., Leung K.H., Mak W.N., Cai J., Li X., Chan J.F.W., Lau S.K.P., Woo P.C.Y., Lai W.M., Kwan T.H., Au T.W.K., Lo C.M., Wong C.Y.S. and Yuen K.Y., Donor-Derived Genotype 4 Hepatitis E Virus Infection, Hong Kong, China, 2018, Emerging Infectious Diseases. 2019, 25: 425-433.
Wong C.Y.S., Poon W.S.R., Foo C.H., Ngan A.H.Y., Tse H., Lam C.M.V., Leung H.Y., Wong C.P., Cheng C.C.V., Chen H.K.J. and Yuen K.Y., Novel selective medium for the isolation of corynebacterium kroppenstedtii from heavily colonised clinical specimens , Journal of Clinical Pathology. 2018, 71: 781-786.


Researcher : Wong HYB

List of Research Outputs

Wen L.R., Chu H., Wong H.Y.B., Wang D., Li C., Zhao X., Chiu M.C., Yuan S., Fan Y., Chen H., Zhou J. and Yuen K.Y., Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses, Emerging Microbes & Infections. New York, USA, NPG, 2018, 7.
Zhang K., Li C., Luo Y.S., Wen L.R., Yuan S., Wang D., WONG H.Y.B., Zhao X., Chiu M.C., Ye Z., Sun Z., Zhao H., ZHANG X., Hu M., Yang D., Shuai H.V., Wang Y., He J., Bose M.E., Henrickson K.J., Huang J., Zheng B., Chu H. and Zhou J., Establishment of a lethal aged mouse model of human respiratory syncytial virus infection, Antiviral Research. 2019, 161: 125-133.
Zhou J., WANG D., WONG H.Y.B., Chu H. and Yuen K.Y., Identification and characterization of GLDC as host susceptibility gene to severe influenza., EMBO Molecular Medicine. 2018.


Researcher : Wong LWM

List of Research Outputs

Yeung M.L., JIA L., Yip C.Y., Chan J.F.W., Teng L.L., Chan K.H., Cai J., ZHANG C., Zhang J., Wong L.W.M., Kok K.H., Lau S.K.P., Woo P.C.Y., Lo J.Y.C., Jin D., Shih S.R. and Yuen K.Y., Human tryptophanyl-tRNA synthetase is an IFN-γ–inducible entry factor for Enterovirus, Journal of Clinical Investigation. 2018, 128: 5163-5177.


Researcher : Wong PC

List of Research Outputs

Wen W.E.I., Xiong L., Ye Y.N., Du M.Z., Gao Y.Z., Zhang K.Y., Jin Y.T., Yang Z.J., Wong P.C., Lau S.K.P., Kan B., Zhu J., Woo P.C.Y. and Guo F.B., Mutation Landscape Of Base Substitutions, Duplications And Deletions In The Representative Current Cholera Pandemic Strain, Genome Biology And Evolution. 2018.


Researcher : Wong SC

List of Research Outputs

Cheng C.C.V., Wong S.C., Wong C.Y.S., Ho P.L. and Yuen K.Y., Control of Carbapenemase-producing Enterobacteriaceae: Beyond the Hospital, EClinicalMedicine. 2018, 6: 3-4.
Cheng C.C.V., Wong S.C., Wong S.C.Y. and Yuen K.Y., Directly observed hand hygiene – from healthcare workers to patients, Journal of Hospital Infection. 2019, 101: 380-382.
Cheng C.C.V., Wong S.C., Chen H.K.J., Wong C.Y.S. and Yuen K.Y., Mycobacterium chimaera -contaminated heater–cooler devices: the inner surface as the missing link?, Journal of Hospital Infection. 2018.
Cheng C.C.V., Wong S.C., Wong C.Y.S., Sridhar S., Yip C.Y., Chen H.K.J., Fung J., Chiu H.Y.K., Ho P.L., Chen S., Cheng B.W.C., Ho C.L., Lo C.M. and Yuen K.Y., Nosocomial transmission of hepatitis C virus in a liver transplant center in Hong Kong: implication of reusable blood collection tube holder as the vehicle for transmission, Infection Control & Hospital Epidemiology. 2018, 39: 1170-1177.
Cheng C.C.V., Wong S.C., Wong C.Y.S., Sridhar S., Yip C.Y., Chen H.K.J., Fung J., Chiu H.Y.K., Ho P.L., Chen S., Cheng B.W.C., Ho S.L., Lo C.M. and Yuen K.Y., Reusable blood collection tube holders are implicated in nosocomial hepatitis C virus transmission, Infection Control & Hospital Epidemiology. 2019, 40: 252-253.
Sridhar S., Cheng C.C.V., Wong S.C., Yip C.Y., Wu S., Lo A.W.I., Leung K.H., Mak W.N., Cai J., Li X., Chan J.F.W., Lau S.K.P., Woo P.C.Y., Lai W.M., Kwan T.H., Au T.W.K., Lo C.M., Wong C.Y.S. and Yuen K.Y., Donor-Derived Genotype 4 Hepatitis E Virus Infection, Hong Kong, China, 2018, Emerging Infectious Diseases. 2019, 25: 425-433.


Researcher : Wong SSY

Project Title:Molecular characterization of streptococcus bovis bacteraemia
Investigator(s):Wong SSY, Yuen KY, Woo PCY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:11/2003


Project Title:Characterization of bacterial isolates with ambiguous biochemical profiles recovered from patients with clinically significant bacteremia by 16S rRNA gene sequencing, the state-of-the-art molecular technique for bacterial identification
Investigator(s):Wong SSY, Woo PCY, Lau SKP
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:11/2004


Project Title:Prevalence of extended spectrum beta-lactamase (ESBL)-producing Laribacter hongkongensis in patients and freshwater fish in Hong Kong
Investigator(s):Wong SSY, Teng LL, Lau SKP, Woo PCY
Department:Microbiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2017
Completion Date:06/2019


List of Research Outputs

Guan T.P., Teng L.L., Yeong K.Y., You Z.Q., Liu H., Wong S.S.Y., Lau S.K.P. and Woo P.C.Y., Metagenomic Analysis Of Sichuan Takin Fecal Sample Viromes Reveals Novel Enterovirus And Astrovirus, Virology. 2018, 521: 77-91.
TAM K.G.K., Leung S.S., Siu G.K.H., CHANG K.C., Wong S.S.Y., Ho P.L., Leung K.C. and Yam W.C., Direct detection of pyrazinamide resistance in Mycobacterium tuberculosis by use of pncA PCR sequencing. , Journal of Clinical Microbiology. American Society of Microbiology, 2019, 57.
Teng L.L., Tang Y., Wong S.S.Y., Fong Y.H., Zhao Z.H.E., Wong C.P., Chen H.K.J., Ngan A.K.L., Wu K.L.A., Fung S.C.K., Que T.L., Lau S.K.P. and Woo P.C.Y., Maldi-tof Ms For Identification Of Tsukamurella Species: Tsukamurella Tyrosinosolvens As The Predominant Species Associated With Ocular Infections, Emerging Microbes & Infections. 2018, 7.
Wong S.S.Y., Yip C.Y., Sridhar S., Leung K.H., Cheng A.K.W., Fung A.M.Y., Lam H.Y., Chan K.H., Chan J.F.W., Cheng C.C.V., Tang B.S.F. and Yuen K.Y., Comparative evaluation of a laboratory-developed real-time PCR assay and RealStar® Adenovirus PCR Kit for quantitative detection of human adenovirus, Virology Journal. 2018, 15.
Wong S.S.Y., Malaria in non-endemic areas, HA Convention 2019. 2019.


Researcher : Wong YC

Project Title:Immune control of SHIV infection in rhesus macaques by PD-1 based vaccine
Investigator(s):Wong YC, Chen Z
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:08/2018


List of Research Outputs

LIU W., Wong Y.C., CHEN S.M.Y., TANG J., Wang H., Cheung K.L.A. and Chen Z., DNA prime/MVTT boost regimen with HIV-1 mosaic Gag enhances the potency of antigen-specific immune responses, Vaccine. 2018, 36: 4621-4632.
Wong Y.C., New Investigator Award, 2018 HIV Research for Prevention (HIVR4P) Conference. 2018.


Researcher : Wong YM

List of Research Outputs

Lau S.K.P., Wong Y.M., Tsang C.C., Ahmed S.S., Au Yeung K.H.R., Yuen K.Y., Wernery U. and Woo P.C.Y., Discovery and sequence analysis of four deltacoronaviruses from birds in the Middle East reveal interspecies jumping with recombination as a potential mechanism for avian-to-avian and avian-to-mammalian transmission, Journal of Virology. 2018, 92: e00265-18.


Researcher : Woo P.C.Y.

Project Title:Infection and Immunology
Investigator(s):Woo PCY, Yuen KY, Watt RM
Department:Microbiology
Source(s) of Funding:Seed Funding for Strategic Research Theme
Start Date:06/2013


Project Title:Molecular epidemiology of superficial infections by non-dermatophytic moulds in Hong Kong
Investigator(s):Woo PCY, Lau SKP, Chan JFW
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:12/2014


Project Title:Molecular Basis for Interspecies Transmission and Pathogenesis of Middle East Respiratory Syndrome Coronavirus
Investigator(s):Woo PCY, Lau SKP, Jin D, Yuen KY, Chen H, Kao RYT, Zheng B, Sham PC, Teng LL, Chan JFW, Tse H, Zhang J, Kok KH, Sze KH, Tanner JA, Yeung ML, Zhou J, Chu H, To KKW
Department:Microbiology
Source(s) of Funding:Theme-based Research Scheme
Start Date:11/2015


Project Title:Genome manipulation of the medically important, thermally dimorphic fungus Talaromyces marneffei
Investigator(s):Woo PCY, Lau SKP, Kok KH
Department:Microbiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:01/2017


Project Title:Development of a rapid antigen detection assay with high specificity and sensitivity for early diagnosis of Middle East Respiratory Syndrome in clinical microbiology laboratories
Investigator(s):Woo PCY, Lau SKP
Department:Microbiology
Source(s) of Funding:Seed Fund for Translational and Applied Research
Start Date:04/2017


Project Title:Mechanistic study on the immune evasion of Talaromyces marneffei - conidial interaction with human macrophages and bronchial epithelial cells
Investigator(s):Woo PCY, Lau SKP, Kok KH, Tsang CC
Department:Microbiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:04/2018


Project Title:Pathogen diagnosis and surveillance and research in Ocean Park animals
Investigator(s):Woo PCY, Lau SKP, Teng LL
Department:Microbiology
Source(s) of Funding:Ocean Park Research Project
Start Date:09/2018


Project Title:Mechanistic study on the pathogenesis of Talaromyces marneffei - conidial interaction with human bronchial epithelial cells
Investigator(s):Woo PCY, Kok KH, Tsang CC, Lau SKP
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2019


Project Title:Understanding Talaromyces marneffei infections in vivo by single-cell RNA sequencing
Investigator(s):Woo PCY, Lau SKP, Tsang CC, Chow WNF
Department:Microbiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:04/2019


Project Title:Diagnosing Fungal Infections By Artificial Intelligence
Investigator(s):Woo PCY, Yiu SM, Lau SKP, Schnieders D, Tsang CC
Department:Microbiology
Source(s) of Funding:Midstream Research Programme for Universities (MRP)
Start Date:04/2019


Project Title:Diagnosing Fungal Infections By Artificial Intelligence
Investigator(s):Woo PCY, Yiu SM, Lau SKP, Schnieders D, Tsang CC
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:04/2019


Project Title:Diagnosing Fungal Infections By Artificial Intelligence
Investigator(s):Woo PCY, Yiu SM, Lau SKP, Schnieders D, Tsang CC
Department:Microbiology
Source(s) of Funding:Postdoctoral Hub Programme for ITF projects
Start Date:04/2019


Project Title:Diagnosing Fungal Infections By Artificial Intelligence
Investigator(s):Woo PCY, Yiu SM, Lau SKP, Schnieders D, Tsang CC
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:04/2019


Project Title:Diagnosing Fungal Infections By Artificial Intelligence
Investigator(s):Woo PCY, Yiu SM, Lau SKP, Schnieders D, Tsang CC
Department:Microbiology
Source(s) of Funding:Postdoctoral Hub Programme for ITF projects
Start Date:04/2019


Project Title:Use of artificial intelligence in diagnosing bacterial vaginosis
Investigator(s):Woo PCY, Lau SKP, Yiu SM, Tsang CC, Schnieders D
Department:Microbiology
Source(s) of Funding:Seed Fund for Translational and Applied Research
Start Date:04/2019


List of Research Outputs



Researcher : Woo PCY

Project Title:Infection and Immunology
Investigator(s):Woo PCY, Yuen KY, Watt RM
Department:Microbiology
Source(s) of Funding:Seed Funding for Strategic Research Theme
Start Date:06/2013


Project Title:Molecular epidemiology of superficial infections by non-dermatophytic moulds in Hong Kong
Investigator(s):Woo PCY, Lau SKP, Chan JFW
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:12/2014


Project Title:Molecular Basis for Interspecies Transmission and Pathogenesis of Middle East Respiratory Syndrome Coronavirus
Investigator(s):Woo PCY, Lau SKP, Jin D, Yuen KY, Chen H, Kao RYT, Zheng B, Sham PC, Teng LL, Chan JFW, Tse H, Zhang J, Kok KH, Sze KH, Tanner JA, Yeung ML, Zhou J, Chu H, To KKW
Department:Microbiology
Source(s) of Funding:Theme-based Research Scheme
Start Date:11/2015


Project Title:Genome manipulation of the medically important, thermally dimorphic fungus Talaromyces marneffei
Investigator(s):Woo PCY, Lau SKP, Kok KH
Department:Microbiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:01/2017


Project Title:Development of a rapid antigen detection assay with high specificity and sensitivity for early diagnosis of Middle East Respiratory Syndrome in clinical microbiology laboratories
Investigator(s):Woo PCY, Lau SKP
Department:Microbiology
Source(s) of Funding:Seed Fund for Translational and Applied Research
Start Date:04/2017


Project Title:Mechanistic study on the immune evasion of Talaromyces marneffei - conidial interaction with human macrophages and bronchial epithelial cells
Investigator(s):Woo PCY, Lau SKP, Kok KH, Tsang CC
Department:Microbiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:04/2018


Project Title:Pathogen diagnosis and surveillance and research in Ocean Park animals
Investigator(s):Woo PCY, Lau SKP, Teng LL
Department:Microbiology
Source(s) of Funding:Ocean Park Research Project
Start Date:09/2018


Project Title:Mechanistic study on the pathogenesis of Talaromyces marneffei - conidial interaction with human bronchial epithelial cells
Investigator(s):Woo PCY, Kok KH, Tsang CC, Lau SKP
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2019


Project Title:Understanding Talaromyces marneffei infections in vivo by single-cell RNA sequencing
Investigator(s):Woo PCY, Lau SKP, Tsang CC, Chow WNF
Department:Microbiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:04/2019


Project Title:Diagnosing Fungal Infections By Artificial Intelligence
Investigator(s):Woo PCY, Yiu SM, Lau SKP, Schnieders D, Tsang CC
Department:Microbiology
Source(s) of Funding:Midstream Research Programme for Universities (MRP)
Start Date:04/2019


Project Title:Diagnosing Fungal Infections By Artificial Intelligence
Investigator(s):Woo PCY, Yiu SM, Lau SKP, Schnieders D, Tsang CC
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:04/2019


Project Title:Diagnosing Fungal Infections By Artificial Intelligence
Investigator(s):Woo PCY, Yiu SM, Lau SKP, Schnieders D, Tsang CC
Department:Microbiology
Source(s) of Funding:Postdoctoral Hub Programme for ITF projects
Start Date:04/2019


Project Title:Diagnosing Fungal Infections By Artificial Intelligence
Investigator(s):Woo PCY, Yiu SM, Lau SKP, Schnieders D, Tsang CC
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:04/2019


Project Title:Diagnosing Fungal Infections By Artificial Intelligence
Investigator(s):Woo PCY, Yiu SM, Lau SKP, Schnieders D, Tsang CC
Department:Microbiology
Source(s) of Funding:Postdoctoral Hub Programme for ITF projects
Start Date:04/2019


Project Title:Use of artificial intelligence in diagnosing bacterial vaginosis
Investigator(s):Woo PCY, Lau SKP, Yiu SM, Tsang CC, Schnieders D
Department:Microbiology
Source(s) of Funding:Seed Fund for Translational and Applied Research
Start Date:04/2019


List of Research Outputs

Cao H., XIA T., LI Y., XU Z., Bougouffa S., Lo Y., Bajic V.B., Luo H., Woo P.C.Y. and Yan A., A multidrug resistant clinical P. aeruginosa isolate in the MLST550 clonal complex: uncoupled quorum sensing modulates the interplay of virulence and resistance , Antimicrobial Agents and Chemotherapy. 2019, 63: e01944-18.
Chan E., Wu K.L.A., Tse C.W.S., Lau S.K.P. and Woo P.C.Y., In vitro susceptibility of ceftolozane-tazobactam against Salmonella enterica Serovar Typhi., Journal of Antimicrobial Chemotherapy. 2018, 74: 528-530.
Chaturvedi V., Bouchara J., Hagen F., Alastruey-Izquierdo A., Badali H., Bocca A.L., Cano-Lira J.O.S.E. .F., Cao C., Chaturvedi S., Chotirmall S.H., Diepeninge A.D.V., Gangneux J.P., Guinea J., Hoog S.D., Ilkit M., Kano R., Liu W., Martinez-Rossi N.M., Melhem M., Ono M.A., Ran Y.U.P.I.N.G., Ranque S., Soares C.M.A., Sugita T., Thomas P.A., Vecchiarelli A., Wengenack N.L., Woo P.C.Y., Xu J. and Zancope-Oliveira R.M., Eighty Years of Mycopathologia: A Retrospective Analysis of Progress Made in Understanding Human and Animal Fungal Pathogens, Mycopathologia. 2018, 183: 859–877.
Chong Y.K., Ho C.C., Leung S.Y., Lau S.K.P. and Woo P.C.Y., Clinical Mass Spectrometry in the Bioinformatics Era: A Hitchhiker’s Guide, Computational and Structural Biotechnology Journal. 2018, 16: 316-334.
Chong Y.K., Ho C.C., Leung S.Y., Lau S.K.P. and Woo P.C.Y., Clinical Mass Spectrometry in the Bioinformatics Era: A Hitchhiker’s Guide, Computational and Structural Biotechnology Journal. 2018, 16: 316-334.
Churgin S.M., Teng L.L., Ho J.H.P., Graydon R., Martelli P., Lee F.K., Hui S.W., Fong J.Y.H., Lau S.K.P. and Woo P.C.Y., First case report of fatal Nocardia nova infection in yellow-bibbed lory (Lorius chlorocercus) identified by multilocus sequencing, BMC Veterinary Research. 2019, 15: 4.
Fung S.Y., Chan C.P., Zhu L., Yuen K.Y., Woo P.C.Y., Cai Z. and Jin D., Middle East respiratory syndrome coronavirus ORF4b protein targets cGAS-STING pathway of nucleic acid sensing., Keystone Symposium on “Framing the Response to Emerging Virus Infections“, Pokfulam, Hong Kong. 2018.
Guan T.P., Teng L.L., Yeong K.Y., You Z.Q., Liu H., Wong S.S.Y., Lau S.K.P. and Woo P.C.Y., Metagenomic Analysis Of Sichuan Takin Fecal Sample Viromes Reveals Novel Enterovirus And Astrovirus, Virology. 2018, 521: 77-91.
Lam W.H., Sze K.H., Ke Y., Tse M.K., Zhang H., Woo P.C.Y., Lau S.K.P., Lau C.C.Y., Xu S., Lai P.M., Zhou T., Antonyuk S.V., Kao R.Y.T., Yuen K.Y. and Hao Q., Talaromyces marneffei Mp1 Protein, a Novel Virulence Factor, Carries Two Arachidonic Acid-Binding Domains To Suppress Inflammatory Responses in Hosts , Infection and Immunity. 2019, 87.
Lau S.K.P., Xing F., Tsang C.C., TANG Y.M., TAN Y.P., Ye H., Lau R.W.T., Chen H.K.J., Lo S.K.F. and Woo P.C.Y., Clinical characteristics, rapid identification, molecular epidemiology and antifungal susceptibilities of Talaromyces marneffei infections in Shenzhen, China, Mycoses. 2019, 62: 450-457.
Lau S.K.P., Wong Y.M., Tsang C.C., Ahmed S.S., Au Yeung K.H.R., Yuen K.Y., Wernery U. and Woo P.C.Y., Discovery and sequence analysis of four deltacoronaviruses from birds in the Middle East reveal interspecies jumping with recombination as a potential mechanism for avian-to-avian and avian-to-mammalian transmission, Journal of Virology. 2018, 92: e00265-18.
Lau S.K.P., ZHAO S., Sridhar S., Yip C.Y., AW YONG K.L., Chow E.Y.Y., Cheung K.C.M., Hui R.W.H., Leung R.Y.H., Lai S.K., Wu A.K.L., To K.K.W., Woo P.C.Y. and Yuen K.Y., Molecular epidemiology of coxsackievirus A6 circulating in Hong Kong reveals common neurological manifestations and emergence of novel recombinant groups, Journal of Clinical Virology. 2018, 108: 43-49.
Lau S.K.P., Wong A.C.P., Zhang L., Luk H.K.H., Kwok J.S.L., Ahmed S.S., Cai J., Zhao P.S.H., Teng L.L., Tsui S.K.W., Yuen K.Y. and Woo P.C.Y., Novel Bat Alphacoronaviruses in Southern China Support Chinese Horseshoe Bats as an Important Reservoir for Potential Novel Coronaviruses, Viruses. 2019, 11: 423.
Lau S.K.P. and Woo P.C.Y., Pitfalls in big data analysis: next generation technologies, last generation data, Diagnostic Microbiology and Infectious Disease. 2019, 94: 209-210.
Lau S.K.P., Fan R.Y.Y., Luk H.K.H., Zhu L., Fung J., Li K.S.M., Wong W.Y.M., Ahmed S.S., Chan J.F.W., Kok K.H., Chan K.H., Wernery U., Yuen K.Y. and Woo P.C.Y., Replication of MERS and SARS coronaviruses in bat cells offers insights to their ancestral origins, Emerging Microbes & Infections. 2018, 7: 1-11.
Lim C.C., Woo P.C.Y. and Lim T.S., Development of a phage display panning strategy utilizing crude antigens: isolation of MERS-CoV nucleoprotein human antibodies, Scientific Reports. 2019, 9: 6088.
Luk K.H., Li X., FUNG J., Lau S.K.P. and Woo P.C.Y., Molecular epidemiology, evolution and phylogeny of SARS coronavirus, Infection, Genetics and Evolution. 2019, 71: 21-30.
Meyer W., Irinyi L., Hoang M.T.V., Robert V., Garcia-Hermoso D., Desnos-Ollivier M., Yurayart C., Tsang C.C., Lee C.Y., Woo P.C.Y., Pchelin I.M., Uhrlaß S., Nenoff P., Chindamporn A., Chen S., Hebert P.D.N. and Sorrell T.C., Database establishment for the secondary fungal DNA barcode -Translational Elongation Factor 1α (TEF1α), Genome. Canadian Science Publishing, 2019, 62: 160-169.
Sridhar S., Cheng C.C.V., Wong S.C., Yip C.Y., Wu S., Lo A.W.I., Leung K.H., Mak W.N., Cai J., Li X., Chan J.F.W., Lau S.K.P., Woo P.C.Y., Lai W.M., Kwan T.H., Au T.W.K., Lo C.M., Wong C.Y.S. and Yuen K.Y., Donor-Derived Genotype 4 Hepatitis E Virus Infection, Hong Kong, China, 2018, Emerging Infectious Diseases. 2019, 25: 425-433.
Sridhar S., Chung T.W.H., Chan J.F.W., Cheng C.C.V., Lau S.K.P., Yuen K.Y. and Woo P.C.Y., Emergence of Cytomegalovirus Mononucleosis Syndrome Among Young Adults in Hong Kong Linked to Falling Seroprevalence: Results of a 14-Year Seroepidemiological Study, Open Forum Infectious Diseases. 2018, 5.
Sridhar S., Yip C.Y., Wu S., Cai J., Zhang J., Leung K.H., Chung T.W.H., Chan J.F.W., Chan W.M., Teng L.L., Au-Yeung R.K.H., Cheng C.C.V., Chen H., Lau S.K.P., Woo P.C.Y., Xia N.S., Lo C.M. and Yuen K.Y., Rat Hepatitis E Virus as Cause of Persistent Hepatitis after Liver Transplant, Emerging Infectious Diseases. 2018, 24: 2241-2250.
Sridhar S., Wu S. and Woo P.C.Y., SEROLOGICAL SUSCEPTIBILITY OF IMMUNOCOMPROMISED TRANSPLANT RECIPIENTS TO HEPATITIS E INFECTION IN HONG KONG: A HEPATITIS E VIRUS GENOTYPE 4 ENDEMIC REGION, 17th Asia-Pacific Congress of Clinical Microbiology and Infection . 2018.
Sun H., Wang R., LAI T.P., Ho P.L., Woo P.C.Y., Kao R.Y.T. and Li H., From metallomics to drug development: bismuth-based agents as inhibitors against metallo-β-lactamase , 14th European Biological Inorganic Chemistry Conference (EuroBIC-14), Birmingham, UK, August 26-30, 2018. 2018.
Sun H., WANG R., LAI T.P., Ho P.L., Woo P.C.Y., Kao R.Y.T. and Li H., From metallomics to drug development: bismuth-based agents as inhibitors against metallo-β-lactamase, 11th International BioMetals Symposium (BioMetals-2018), Ottawa, Canada, July 15-19, 2018. 2018.
Teng L.L., Tang Y., Wong S.S.Y., Fong Y.H., Zhao Z.H.E., Wong C.P., Chen H.K.J., Ngan A.K.L., Wu K.L.A., Fung S.C.K., Que T.L., Lau S.K.P. and Woo P.C.Y., Maldi-tof Ms For Identification Of Tsukamurella Species: Tsukamurella Tyrosinosolvens As The Predominant Species Associated With Ocular Infections, Emerging Microbes & Infections. 2018, 7.
Tsang C.C., TANG Y.M., CHAN K.F., Lee C.Y., Chan J.F.W., Ngan A.H.Y., Cheung M., Lau E.C.L., Li X., Ng R.H.Y., Lai C.K.C., Fung S.C.K., Lau S.K.P. and Woo P.C.Y., Diversity of phenotypically non-dermatophyte, non-Aspergillus filamentous fungi causing nail infections: importance of accurate identification and antifungal susceptibility testing, Emerging Microbes & Infections. 2019, 8: 531-541.
Tsang C.C., TANG Y.M., FONG Y.H., Kinne J., LEE H.H., Joseph M., Jose S., Schuster R.K., Tang Y., Sivakumar S., Chen H.K.J., Teng L.L., Lau S.K.P., Wernery U. and Woo P.C.Y., Ignatzschineria cameli sp. nov., isolated from necrotic foot tissue of dromedaries (Camelus dromedarius) and associated maggots (Wohlfahrtia species) in Dubai, International Journal of Systematic and Evolutionary Microbiology. 2018, 68: 3627-3634.
WONG L.Y.R., Lui P.Y., Siu K.L., Yeung M.L., Yuen K.S., Fung S.Y., Chan C.P., Woo P.C.Y., Yuen K.Y. and Jin D., Middle-East respiratory syndrome coronavirus ORF8b protein suppresses type I interferon production by interacting with HSP70, The American Society for Virology 37th Annual Meeting, University of Maryland, College Park, Maryland, USA, July 14-18, 2018.. 2018.
WONG L.Y.R., Ye Z., Lui P.Y., Siu K.L., Yeung M.L., Yuen K.S., Fung S.Y., Chan C.P., Cai Z., Woo P.C.Y., Yuen K.Y. and Jin D., Suppression of type I interferon production by Middle East respiratory syndrome coronavirus ORF8b accessory protein through interaction with HSP70 chaperone, Keystone Symposium on “Framing the Response to Emerging Virus Infections”, Pokfulam, Hong Kong. 2018.
Wang L., Teng L.L., Lau S.K.P., Sridhar S., Fu H., Gong W., Li M., Xu Q., He Y., Zhuang H., Woo P.C.Y. and Wang L., Transmission of a Novel Genotype of Hepatitis E Virus from Bactrian Camels to Cynomolgus Macaques, Journal of Virology. 2019, 93.
Wen W.E.I., Xiong L., Ye Y.N., Du M.Z., Gao Y.Z., Zhang K.Y., Jin Y.T., Yang Z.J., Wong P.C., Lau S.K.P., Kan B., Zhu J., Woo P.C.Y. and Guo F.B., Mutation Landscape Of Base Substitutions, Duplications And Deletions In The Representative Current Cholera Pandemic Strain, Genome Biology And Evolution. 2018.
Wernery U., Tsang C.C., Hebel C., Damerau A., Kinne J., Cai J., Küspert H., Chan K.F., Joseph M., XUE S., Raghavan R., Tang Y.M.J., Syriac G., Lau S.K.P., Jose S. and Woo P.C.Y., Serodiagnosis of aspergillosis in falcons (Falco spp.) by an Afmp1p-based enzyme-linked immunosorbent assay, Mycoses. Blackwell Verlag GmbH, 2018, 61: 600-609.
Wong C.P., Li X., Lau S.K.P. and Woo P.C.Y., Global Epidemiology of Bat Coronaviruses, Viruses. 2019, 11(2): 174.
Woo P.C.Y., Antifungal susceptibility testing, Medical Mycology Training Network Conference 2018 (Taipei, Taiwan). 2018.
Woo P.C.Y., Carbapenem resistance and development of Hong Kong antimicrobial stewardship program. Hong Kong-Shenzhen Antimicrobial Stewardship Expert Meeting, Hong Kong. 2019.
Woo P.C.Y., Editorial Board member, Cell and Bioscience. 2018.
Woo P.C.Y., Invasive pneumococcal disease surveillance and pneumococcal vaccination program in Hong Kong. Mainland-Taiwan-Hong Kong Advisory Board on Pneumococcal Disease, Beijing, China. 2019.
Woo P.C.Y., Medical Mycology Training Network Conference 2018 (Taipei, Taiwan) , Medical Mycology Training Network Conference 2018 (Taipei, Taiwan). 2018.
Woo P.C.Y., Molecular identification and characterization of emerging and novel mold pathogens., Medical Mycology Training Network Conference 2018 (Taipei, Taiwan) . 2018.
Woo P.C.Y., Teng L.L., Bai R., Tang Y., Wong A.Y.P., Li K.S.M., Lam C.S.F., Fan R.Y.Y., Lau S.K.P. and Yuen K.Y., Novel Picobirnaviruses in Respiratory and Alimentary Tracts of Cattle and Monkeys with Large Intra- and Inter-Host Diversity, Viruses. 2019, 11: 574.
Woo P.C.Y., Novel hepatitis E viruses from camels: an emerging cause of hepatitis E virus infections in human, Guangdong Academy of Agricultural Sciences. 2018.
Woo P.C.Y., Novel hepatitis E viruses from camels: an emerging cause of human hepatitis E virus infections, Annual Scientific Meeting for Taiwan Society of Microbiology (Taipei, Taiwan) . 2018.
Woo P.C.Y., Talaromyces and mucormycosis, Fifth Asia CARE Forum. 2018.
Woo P.C.Y., What have we learned from the Talaromyces marneffei genome so far? , Medical Mycology Training Network Conference 2018 (Taipei, Taiwan). 2018.
Yeung M.L., JIA L., Yip C.Y., Chan J.F.W., Teng L.L., Chan K.H., Cai J., ZHANG C., Zhang J., Wong L.W.M., Kok K.H., Lau S.K.P., Woo P.C.Y., Lo J.Y.C., Jin D., Shih S.R. and Yuen K.Y., Human tryptophanyl-tRNA synthetase is an IFN-γ–inducible entry factor for Enterovirus, Journal of Clinical Investigation. 2018, 128: 5163-5177.
Zhang J., Kang J., Dehghan S., Sridhar S., Lau S.K.P., Ou J., Woo P.C.Y., Zhang Q. and Seto D., A survey of recent adenoviral respiratory pathogens in Hong Kong reveals emergent and recombinant human adenovirus type 4 (HAdV-E4) circulating in civilian populations, Viruses. 2019, 11(2): 129.
Zhao Y., Tsang C.C., Xiao M., Chan J.F.W., Lau S.K.P., Kong F., Xu Y. and Woo P.C.Y., Yeast identification by sequencing, biochemical kits, MALDI–TOF MS and rep-PCR DNA fingerprinting, Yeast identification by sequencing, biochemical kits, MALDI–TOF MS and rep-PCR DNA fingerprinting. 2018, 56: 816–827.
Zhou P.S.H., Yip C.Y., Sridhar S., Chow W.N., To K.K.W., Chan K.H., Chan J.F.W., Cheng C.C.V., Yuen K.Y., Woo P.C.Y. and Lau S.K.P., Identification And Characteristics Of The Newly Emerged Subclades Of Enterovirus D68 Associated With Severe Respiratory/central Nervous System Infections In Hong Kong. Australia Society For Microbiology Annual Scientific Meeting 2018, (Brisbane, Australia). 2018.


Researcher : Wu KLA

List of Research Outputs

Cao H., Wong C.Y.S., Yam W.C., LIU C., Chow K.H., Wu K.L.A. and Ho P.L., Genomic investigation of a sequence type 67 Clostridium difficile causing community-acquired fulminant colitis in Hong Kong, International Journal of Medical Microbiology. 2019.
Chan E., Wu K.L.A., Tse C.W.S., Lau S.K.P. and Woo P.C.Y., In vitro susceptibility of ceftolozane-tazobactam against Salmonella enterica Serovar Typhi., Journal of Antimicrobial Chemotherapy. 2018, 74: 528-530.
Teng L.L., Tang Y., Wong S.S.Y., Fong Y.H., Zhao Z.H.E., Wong C.P., Chen H.K.J., Ngan A.K.L., Wu K.L.A., Fung S.C.K., Que T.L., Lau S.K.P. and Woo P.C.Y., Maldi-tof Ms For Identification Of Tsukamurella Species: Tsukamurella Tyrosinosolvens As The Predominant Species Associated With Ocular Infections, Emerging Microbes & Infections. 2018, 7.
Wang Y.L., TONG M.K., Chow K.H., Cheng C.C.V., TSE C.W., Wu K.L.A., LAI R.W., Luk W.K., Tsang D.N.C. and Ho P.L., Occurrence of Highly Conjugative IncX3 Epidemic Plasmid Carrying blaNDM in Enterobacteriaceae Isolates in Geographically Widespread Areas, Frontiers in Microbiology. 2018, 9.


Researcher : Wu S

List of Research Outputs

Sridhar S., Cheng C.C.V., Wong S.C., Yip C.Y., Wu S., Lo A.W.I., Leung K.H., Mak W.N., Cai J., Li X., Chan J.F.W., Lau S.K.P., Woo P.C.Y., Lai W.M., Kwan T.H., Au T.W.K., Lo C.M., Wong C.Y.S. and Yuen K.Y., Donor-Derived Genotype 4 Hepatitis E Virus Infection, Hong Kong, China, 2018, Emerging Infectious Diseases. 2019, 25: 425-433.
Sridhar S., Wu S. and Chew N.F.S., Prevalence Of Human Hepegivirus - 1 In Hepatitis C Infected Individuals, Hong Kong , Clinical Virology Symposium . 2019.
Sridhar S., Yip C.Y., Wu S., Cai J., Zhang J., Leung K.H., Chung T.W.H., Chan J.F.W., Chan W.M., Teng L.L., Au-Yeung R.K.H., Cheng C.C.V., Chen H., Lau S.K.P., Woo P.C.Y., Xia N.S., Lo C.M. and Yuen K.Y., Rat Hepatitis E Virus as Cause of Persistent Hepatitis after Liver Transplant, Emerging Infectious Diseases. 2018, 24: 2241-2250.
Sridhar S., Wu S. and Woo P.C.Y., SEROLOGICAL SUSCEPTIBILITY OF IMMUNOCOMPROMISED TRANSPLANT RECIPIENTS TO HEPATITIS E INFECTION IN HONG KONG: A HEPATITIS E VIRUS GENOTYPE 4 ENDEMIC REGION, 17th Asia-Pacific Congress of Clinical Microbiology and Infection . 2018.


Researcher : Wu T

List of Research Outputs

LING L., Wu T., To K.K.W., Cheung K.W., Lui K.O., NIU M., LAM K.S., Wang C.C., Li J., Wang H., Yuen K.Y. and Chen Z., Vedolizumab-mediated integrin α4β7 blockade does not control HIV-1SF162 rebound after combination antiretroviral therapy interruption in humanized mice, AIDS. 2019, 33: F1-F12.
Liu L., Wei Q., Lin Q., Fang J., Wang H., Kwok H.Y., Tang H.Y., Nishiura K., Peng J., Wu T., Wu T., Cheung K.W., Chan K.H., Alvarez X., Qin C., Lackner A., Perlman S., Yuen K.Y. and Chen Z., Anti–spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection, JCI Insight. 2019, 4.


Researcher : Wu WL

List of Research Outputs

Bao S., Jia L., Zhou X., ZHANG Z., Wu W.L., Yu Z., NG G.C.T., Fan Y., Wong S.M., Huang S., To K.K.W., Yuen K.Y., Yeung M.L. and Song Y., Integrated analysis of mRNA-seq and miRNA-seq for host susceptibilities to influenza A (H7N9) infection in inbred mouse lines, Functional & Integrative Genomics. 2018, 18: 411-424.


Researcher : XUE S

List of Research Outputs

Wernery U., Tsang C.C., Hebel C., Damerau A., Kinne J., Cai J., Küspert H., Chan K.F., Joseph M., XUE S., Raghavan R., Tang Y.M.J., Syriac G., Lau S.K.P., Jose S. and Woo P.C.Y., Serodiagnosis of aspergillosis in falcons (Falco spp.) by an Afmp1p-based enzyme-linked immunosorbent assay, Mycoses. Blackwell Verlag GmbH, 2018, 61: 600-609.


Researcher : Xing F

List of Research Outputs

Lau S.K.P., Xing F., Tsang C.C., TANG Y.M., TAN Y.P., Ye H., Lau R.W.T., Chen H.K.J., Lo S.K.F. and Woo P.C.Y., Clinical characteristics, rapid identification, molecular epidemiology and antifungal susceptibilities of Talaromyces marneffei infections in Shenzhen, China, Mycoses. 2019, 62: 450-457.


Researcher : Xiong L

List of Research Outputs

Wen W.E.I., Xiong L., Ye Y.N., Du M.Z., Gao Y.Z., Zhang K.Y., Jin Y.T., Yang Z.J., Wong P.C., Lau S.K.P., Kan B., Zhu J., Woo P.C.Y. and Guo F.B., Mutation Landscape Of Base Substitutions, Duplications And Deletions In The Representative Current Cholera Pandemic Strain, Genome Biology And Evolution. 2018.


Researcher : YUEN TT

List of Research Outputs

Chan J.F.W., Chu H., YUEN T.T., Yuan S., ZHU Z. and Yuen K.Y., Targeting the endoplasmic reticulum stress signaling pathways as treatment options for Zika virus infection, 35th ASM Clinical Virology Symposium. 2019.
ZHU Z., Chu H., WEN L., Yuan S., CHIK K.K.H., YUEN T.T., Yip C.Y., WANG D., Zhou J., Yin F., Jin D., Kok K.H., Yuen K.Y. and Chan J.F.W., Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy, International Journal of Molecular Sciences. 2019, 20: 392.


Researcher : Yam WC

Project Title:Detection of HIV-1 minority drug-resistant and X4-tropic variants by Next-Generation Sequencing to improve the prediction of clinical antiretroviral treatment outcome
Investigator(s):Yam WC, To WCS, Panagiotou I, Li J
Department:Microbiology
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:04/2016


List of Research Outputs

Cao H., Wong C.Y.S., Yam W.C., LIU C., Chow K.H., Wu K.L.A. and Ho P.L., Genomic investigation of a sequence type 67 Clostridium difficile causing community-acquired fulminant colitis in Hong Kong, International Journal of Medical Microbiology. 2019.
TAM K.G.K., Leung S.S., Siu G.K.H., CHANG K.C., Wong S.S.Y., Ho P.L., Leung K.C. and Yam W.C., Direct detection of pyrazinamide resistance in Mycobacterium tuberculosis by use of pncA PCR sequencing. , Journal of Clinical Microbiology. American Society of Microbiology, 2019, 57.


Researcher : Yan B

List of Research Outputs

Chan J.F.W., Yuan S., Chu H., Ye Z., Wen L.R., Yan B., To K.K.W., Kao R.Y.T. and Yuen K.Y., Best Poster Award (1st place in the Young Investigator Category), The 32nd International Conference on Antiviral Research (ICAR 2019). 2019.
Chan J.F.W., Yuan S., Chu H., Ye Z., WEN L., Yan B., To K.K.W., Kao R.Y.T. and Yuen K.Y., Identification of Sterol Regulatory Element Binding Protein-Dependent Lipidomic Reprogramming as a Broad-Spectrum Antiviral Target, 32nd International Conference on Antiviral Research (ICAR). 2019.
Yan B., Chu H., Yang D., Sze K.H., Lai P.M., Yuan S., Shuai H.V., Wang Y., Kao R.Y.T., Chan J.F.W. and Yuen K.Y., Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication, Viruses. 2019, 11: 73.


Researcher : Yan CW

List of Research Outputs

Tan Z., Liu L., Chiu M.S., Cheung K.W., Yan C.W., Yu Z., LEE B.K., LIU W., Man K. and Chen Z., Virotherapy-recruited PMN-MDSC infiltration of mesothelioma blocks antitumor CTL by IL-10-mediated dendritic cell suppression, OncoImmunology. 2019, 8: e1518672.


Researcher : Yang D

List of Research Outputs

Chu H., Chan C.M., Zhang X., Wang Y., Yuan S., Zhou J., Au Yeung K.H.R., Sze K.H., Yang D., Shuai H.V., Hou Y., Li C., Zhao X., Poon K.M., Leung A.S.P., Yeung M.L., Yan J., Lu G., Jin D., Gao G.F., Chan J.F.W. and Yuen K.Y., Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells, Journal of Biological Chemistry. 2018, 293: 11709-11726.
Yan B., Chu H., Yang D., Sze K.H., Lai P.M., Yuan S., Shuai H.V., Wang Y., Kao R.Y.T., Chan J.F.W. and Yuen K.Y., Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication, Viruses. 2019, 11: 73.
Zhang K., Li C., Luo Y.S., Wen L.R., Yuan S., Wang D., WONG H.Y.B., Zhao X., Chiu M.C., Ye Z., Sun Z., Zhao H., ZHANG X., Hu M., Yang D., Shuai H.V., Wang Y., He J., Bose M.E., Henrickson K.J., Huang J., Zheng B., Chu H. and Zhou J., Establishment of a lethal aged mouse model of human respiratory syncytial virus infection, Antiviral Research. 2019, 161: 125-133.


Researcher : Ye Z

List of Research Outputs

Chan J.F.W., Yuan S., Chu H., Ye Z., Wen L.R., Yan B., To K.K.W., Kao R.Y.T. and Yuen K.Y., Best Poster Award (1st place in the Young Investigator Category), The 32nd International Conference on Antiviral Research (ICAR 2019). 2019.
Chan J.F.W., Yuan S., Chu H., Ye Z., WEN L., Yan B., To K.K.W., Kao R.Y.T. and Yuen K.Y., Identification of Sterol Regulatory Element Binding Protein-Dependent Lipidomic Reprogramming as a Broad-Spectrum Antiviral Target, 32nd International Conference on Antiviral Research (ICAR). 2019.
WONG L.Y.R., Ye Z., Lui P.Y., Siu K.L., Yeung M.L., Yuen K.S., Fung S.Y., Chan C.P., Cai Z., Woo P.C.Y., Yuen K.Y. and Jin D., Suppression of type I interferon production by Middle East respiratory syndrome coronavirus ORF8b accessory protein through interaction with HSP70 chaperone, Keystone Symposium on “Framing the Response to Emerging Virus Infections”, Pokfulam, Hong Kong. 2018.
Wang F., Ye Z., Deng J., Siu K.L., Gao W., Chaudhary V., Cheng Y., Fung S.Y., Yuen K.S., Ho T.H., Chan C.P., Zhang Y., Kok K.H., Yang W., Chan C.P. and Jin D., Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16. , EMBO reports. 2018.
Wang F., Ye Z., Chan C.P. and Jin D., Putting a brake on inflammasome activation by reprogramming transcription from an alternative promoter: IFI16 as an example, 11th International Singapore Symposium of Immunology, Singapore. 2019.
Ye Z., CHAUDHARY V., Chan J.F.W. and Jin D., Activation of interferon-γ signaling by SFTS virus NSs protein, Keystone Symposium on “Framing the Response to Emerging Virus Infections, Pokfulam, Hong Kong. 2018.
Zhang K., Li C., Luo Y.S., Wen L.R., Yuan S., Wang D., WONG H.Y.B., Zhao X., Chiu M.C., Ye Z., Sun Z., Zhao H., ZHANG X., Hu M., Yang D., Shuai H.V., Wang Y., He J., Bose M.E., Henrickson K.J., Huang J., Zheng B., Chu H. and Zhou J., Establishment of a lethal aged mouse model of human respiratory syncytial virus infection, Antiviral Research. 2019, 161: 125-133.


Researcher : Yeong KY

List of Research Outputs

Guan T.P., Teng L.L., Yeong K.Y., You Z.Q., Liu H., Wong S.S.Y., Lau S.K.P. and Woo P.C.Y., Metagenomic Analysis Of Sichuan Takin Fecal Sample Viromes Reveals Novel Enterovirus And Astrovirus, Virology. 2018, 521: 77-91.


Researcher : Yeung ML

Project Title:Pathogenesis of Middle East Respiratory Syndrome Coronavirus (MERS-CoV)-associated renal failure
Investigator(s):Yeung ML, Yuen KY
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2015
Completion Date:08/2018


List of Research Outputs

Bao S., Jia L., Zhou X., ZHANG Z., Wu W.L., Yu Z., NG G.C.T., Fan Y., Wong S.M., Huang S., To K.K.W., Yuen K.Y., Yeung M.L. and Song Y., Integrated analysis of mRNA-seq and miRNA-seq for host susceptibilities to influenza A (H7N9) infection in inbred mouse lines, Functional & Integrative Genomics. 2018, 18: 411-424.
Chu H., Chan C.M., Zhang X., Wang Y., Yuan S., Zhou J., Au Yeung K.H.R., Sze K.H., Yang D., Shuai H.V., Hou Y., Li C., Zhao X., Poon K.M., Leung A.S.P., Yeung M.L., Yan J., Lu G., Jin D., Gao G.F., Chan J.F.W. and Yuen K.Y., Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells, Journal of Biological Chemistry. 2018, 293: 11709-11726.
WONG L.Y.R., Lui P.Y., Siu K.L., Yeung M.L., Yuen K.S., Fung S.Y., Chan C.P., Woo P.C.Y., Yuen K.Y. and Jin D., Middle-East respiratory syndrome coronavirus ORF8b protein suppresses type I interferon production by interacting with HSP70, The American Society for Virology 37th Annual Meeting, University of Maryland, College Park, Maryland, USA, July 14-18, 2018.. 2018.
WONG L.Y.R., Ye Z., Lui P.Y., Siu K.L., Yeung M.L., Yuen K.S., Fung S.Y., Chan C.P., Cai Z., Woo P.C.Y., Yuen K.Y. and Jin D., Suppression of type I interferon production by Middle East respiratory syndrome coronavirus ORF8b accessory protein through interaction with HSP70 chaperone, Keystone Symposium on “Framing the Response to Emerging Virus Infections”, Pokfulam, Hong Kong. 2018.
Yeung M.L., JIA L., Yip C.Y., Chan J.F.W., Teng L.L., Chan K.H., Cai J., ZHANG C., Zhang J., Wong L.W.M., Kok K.H., Lau S.K.P., Woo P.C.Y., Lo J.Y.C., Jin D., Shih S.R. and Yuen K.Y., Human tryptophanyl-tRNA synthetase is an IFN-γ–inducible entry factor for Enterovirus, Journal of Clinical Investigation. 2018, 128: 5163-5177.


Researcher : Yip CY

List of Research Outputs

Chan J.F.W., Choi G.K.Y., Yip C.Y., ZHU Z., Chan K.H. and Yuen K.Y., Clinical, epidemiological, and molecular analyses of the largest dengue outbreak in Hong Kong in the last 15 years, European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 2019.
Chan J.F.W., Yuan S., CHIK K.K.H., Yip C.Y., Tee K.M., Lai K.K., Kao R.Y.T. and Yuen K.Y., Repurposing novobiocin as a flavivirus protease inhibitor, 67th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2018). 2018.
Cheng C.C.V., Wong S.C., Wong C.Y.S., Sridhar S., Yip C.Y., Chen H.K.J., Fung J., Chiu H.Y.K., Ho P.L., Chen S., Cheng B.W.C., Ho C.L., Lo C.M. and Yuen K.Y., Nosocomial transmission of hepatitis C virus in a liver transplant center in Hong Kong: implication of reusable blood collection tube holder as the vehicle for transmission, Infection Control & Hospital Epidemiology. 2018, 39: 1170-1177.
Cheng C.C.V., Wong S.C., Wong C.Y.S., Sridhar S., Yip C.Y., Chen H.K.J., Fung J., Chiu H.Y.K., Ho P.L., Chen S., Cheng B.W.C., Ho S.L., Lo C.M. and Yuen K.Y., Reusable blood collection tube holders are implicated in nosocomial hepatitis C virus transmission, Infection Control & Hospital Epidemiology. 2019, 40: 252-253.
Guo Q., Chan J.F.W., Poon K.M., Wu S., Chan C.S., Hou L., Yip C.Y., Ren C., Cai J., Zhao M., Zhang J., Song X., Chan K.H., Wang B., Kok K.H., Wen Y., Yuen K.Y. and Chen W., Immunization With a Novel Human Type 5 Adenovirus-Vectored Vaccine Expressing the Premembrane and Envelope Proteins of Zika Virus Provides Consistent and Sterilizing Protection in Multiple Immunocompetent and Immunocompromised Animal Models, The Journal of Infectious Diseases. 2018, 218: 365-377.
Lau S.K.P., ZHAO S., Sridhar S., Yip C.Y., AW YONG K.L., Chow E.Y.Y., Cheung K.C.M., Hui R.W.H., Leung R.Y.H., Lai S.K., Wu A.K.L., To K.K.W., Woo P.C.Y. and Yuen K.Y., Molecular epidemiology of coxsackievirus A6 circulating in Hong Kong reveals common neurological manifestations and emergence of novel recombinant groups, Journal of Clinical Virology. 2018, 108: 43-49.
Sridhar S., Cheng C.C.V., Wong S.C., Yip C.Y., Wu S., Lo A.W.I., Leung K.H., Mak W.N., Cai J., Li X., Chan J.F.W., Lau S.K.P., Woo P.C.Y., Lai W.M., Kwan T.H., Au T.W.K., Lo C.M., Wong C.Y.S. and Yuen K.Y., Donor-Derived Genotype 4 Hepatitis E Virus Infection, Hong Kong, China, 2018, Emerging Infectious Diseases. 2019, 25: 425-433.
Sridhar S., Yip C.Y., Wu S., Cai J., Zhang J., Leung K.H., Chung T.W.H., Chan J.F.W., Chan W.M., Teng L.L., Au-Yeung R.K.H., Cheng C.C.V., Chen H., Lau S.K.P., Woo P.C.Y., Xia N.S., Lo C.M. and Yuen K.Y., Rat Hepatitis E Virus as Cause of Persistent Hepatitis after Liver Transplant, Emerging Infectious Diseases. 2018, 24: 2241-2250.
Wong S.S.Y., Yip C.Y., Sridhar S., Leung K.H., Cheng A.K.W., Fung A.M.Y., Lam H.Y., Chan K.H., Chan J.F.W., Cheng C.C.V., Tang B.S.F. and Yuen K.Y., Comparative evaluation of a laboratory-developed real-time PCR assay and RealStar® Adenovirus PCR Kit for quantitative detection of human adenovirus, Virology Journal. 2018, 15.
Yeung M.L., JIA L., Yip C.Y., Chan J.F.W., Teng L.L., Chan K.H., Cai J., ZHANG C., Zhang J., Wong L.W.M., Kok K.H., Lau S.K.P., Woo P.C.Y., Lo J.Y.C., Jin D., Shih S.R. and Yuen K.Y., Human tryptophanyl-tRNA synthetase is an IFN-γ–inducible entry factor for Enterovirus, Journal of Clinical Investigation. 2018, 128: 5163-5177.
ZHU Z., Chu H., WEN L., Yuan S., CHIK K.K.H., YUEN T.T., Yip C.Y., WANG D., Zhou J., Yin F., Jin D., Kok K.H., Yuen K.Y. and Chan J.F.W., Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy, International Journal of Molecular Sciences. 2019, 20: 392.
Zhou P.S.H., Yip C.Y., Sridhar S., Chow W.N., To K.K.W., Chan K.H., Chan J.F.W., Cheng C.C.V., Yuen K.Y., Woo P.C.Y. and Lau S.K.P., Identification And Characteristics Of The Newly Emerged Subclades Of Enterovirus D68 Associated With Severe Respiratory/central Nervous System Infections In Hong Kong. Australia Society For Microbiology Annual Scientific Meeting 2018, (Brisbane, Australia). 2018.


Researcher : Yuan S

Project Title:Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase
Investigator(s):Yuan S, Kao RYT, Zhou J, Zheng B
Department:Microbiology
Source(s) of Funding:Matching Grant for Joint Research
Start Date:07/2015


List of Research Outputs

Chan J.F.W., Yuan S., Chu H., Ye Z., Wen L.R., Yan B., To K.K.W., Kao R.Y.T. and Yuen K.Y., Best Poster Award (1st place in the Young Investigator Category), The 32nd International Conference on Antiviral Research (ICAR 2019). 2019.
Chan J.F.W., Yuan S., Chu H., Ye Z., WEN L., Yan B., To K.K.W., Kao R.Y.T. and Yuen K.Y., Identification of Sterol Regulatory Element Binding Protein-Dependent Lipidomic Reprogramming as a Broad-Spectrum Antiviral Target, 32nd International Conference on Antiviral Research (ICAR). 2019.
Chan J.F.W., Yuan S., CHIK K.K.H., Yip C.Y., Tee K.M., Lai K.K., Kao R.Y.T. and Yuen K.Y., Repurposing novobiocin as a flavivirus protease inhibitor, 67th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2018). 2018.
Chan J.F.W., Chu H., YUEN T.T., Yuan S., ZHU Z. and Yuen K.Y., Targeting the endoplasmic reticulum stress signaling pathways as treatment options for Zika virus infection, 35th ASM Clinical Virology Symposium. 2019.
Chan J.F.W., TSANG O.L., ZOU Z., CHIK K.K.H., Yuan S., Chu H., Lau S.K.P. and Yuen K.Y., The Cellular Kinase Inhibitor OSU-03012 Inhibits Enterovirus 71 In Vitro, Annual Meeting of the Infectious Diseases Society of America, IDWeek 2018.
Chu H., Chan C.M., Zhang X., Wang Y., Yuan S., Zhou J., Au Yeung K.H.R., Sze K.H., Yang D., Shuai H.V., Hou Y., Li C., Zhao X., Poon K.M., Leung A.S.P., Yeung M.L., Yan J., Lu G., Jin D., Gao G.F., Chan J.F.W. and Yuen K.Y., Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells, Journal of Biological Chemistry. 2018, 293: 11709-11726.
Wen L.R., Chu H., Wong H.Y.B., Wang D., Li C., Zhao X., Chiu M.C., Yuan S., Fan Y., Chen H., Zhou J. and Yuen K.Y., Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses, Emerging Microbes & Infections. New York, USA, NPG, 2018, 7.
Yan B., Chu H., Yang D., Sze K.H., Lai P.M., Yuan S., Shuai H.V., Wang Y., Kao R.Y.T., Chan J.F.W. and Yuen K.Y., Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication, Viruses. 2019, 11: 73.
Yuan S., Chan J.F.W., Ye Z.W., Wen L., Tsang T.G.W., Cao J., Huang J., Chan C.Y.C., Chik K.K.H., Choi G.K.Y., Cai J., Yin F., Chu H., Liang M., Jin D. and Yuen K.Y., Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus, Viruses. 2019, 11: 385.
ZHU Z., Chu H., WEN L., Yuan S., CHIK K.K.H., YUEN T.T., Yip C.Y., WANG D., Zhou J., Yin F., Jin D., Kok K.H., Yuen K.Y. and Chan J.F.W., Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy, International Journal of Molecular Sciences. 2019, 20: 392.
Zhang K., Li C., Luo Y.S., Wen L.R., Yuan S., Wang D., WONG H.Y.B., Zhao X., Chiu M.C., Ye Z., Sun Z., Zhao H., ZHANG X., Hu M., Yang D., Shuai H.V., Wang Y., He J., Bose M.E., Henrickson K.J., Huang J., Zheng B., Chu H. and Zhou J., Establishment of a lethal aged mouse model of human respiratory syncytial virus infection, Antiviral Research. 2019, 161: 125-133.
Zhao H., To K.K.W., Chu H., Ding Q., Zhao X., Li C., Shuai H.V., Yuan S., Zhou J., Kok K.H., Jiang S. and Yuen K.Y., Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza, Nature Communications. 2018, 9.


Researcher : Yuen CKJ

List of Research Outputs

Chan C.P., Yuen C.K.J., CHEUNG P.H.H., Fung S.Y., Lui P.Y., Chen H., Kok K.H. and Jin D., Antiviral activity of double-stranded RNA–binding protein PACT against influenza A virus mediated via suppression of viral RNA polymerase, The FASEB Journal. 2018, 32: 4380-4393.


Researcher : Yuen K.Y.

Project Title:Establishment of core facilities for the HKU HIV/AIDS research laboratories
Investigator(s):Yuen KY, Zheng B, Woo PCY, Yam WC, Im SWK
Department:Microbiology
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:11/2001


Project Title:Special Research Achievement Award 2003-2004
Investigator(s):Yuen KY
Department:Microbiology
Source(s) of Funding:Special Research Achievement Award
Start Date:11/2004


Project Title:Bacteraemia caused by Anaerotruncus colihominis and emended description of the species
Investigator(s):Yuen KY, Lau SKP, Woo PCY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:09/2005


Project Title:Investigation of invasive Lasiodiplodia theobromae infections in humans
Investigator(s):Yuen KY, Tse H, Woo PCY, Lau SKP
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:09/2007


Project Title:Molecular epidemiological investigation of PARV-4-related viruses in HK and southern China
Investigator(s):Yuen KY, Tse H, Lau SKP, Woo PCY
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:10/2008


Project Title:Understanding the evolution and interspecies transmission of betacoronaviruses by structural and biophysical approaches
Investigator(s):Yuen KY, Woo PCY, Lau SKP, Chan JFW
Department:Microbiology
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2015
Completion Date:12/2018


Project Title:Control of viral and multidrug resistant bacterial infections relevant to Hong Kong SAR
Investigator(s):Yuen KY, Jin D, Lau SKP, To KKW, Chan JFW, Sze KH, Tse H, Woo PCY, Hung FNI, Huang J, Ho PL, Kao RYT, Cheng CCV
Department:Microbiology
Source(s) of Funding:Commissioned Research on Control of Infectious Diseases (Phase III)
Start Date:01/2015


Project Title:Research Output Prize (Faculty of Medicine)
Investigator(s):Yuen KY, Hung FNI, Zhang J, To KKW, Chan JFW, Chan TCI, Lau JY, Chen H, Chan KH
Department:Microbiology
Source(s) of Funding:Research Output Prize (in Faculty)
Start Date:11/2016


Project Title:Research and Development of a Rapid Diagnostics and Antiviral Targets
Investigator(s):Yuen KY
Department:Microbiology
Source(s) of Funding:Respiratory Virus Research Foundation Limited
Start Date:06/2017


Project Title:Prevention & Research of Emerging Infectious Viral Diseases
Investigator(s):Yuen KY
Department:Microbiology
Source(s) of Funding:Ministry of Science and Technology of The People's Republic of China (MOST)
Start Date:04/2018


List of Research Outputs



Researcher : Yuen KY

Project Title:Establishment of core facilities for the HKU HIV/AIDS research laboratories
Investigator(s):Yuen KY, Zheng B, Woo PCY, Yam WC, Im SWK
Department:Microbiology
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:11/2001


Project Title:Special Research Achievement Award 2003-2004
Investigator(s):Yuen KY
Department:Microbiology
Source(s) of Funding:Special Research Achievement Award
Start Date:11/2004


Project Title:Bacteraemia caused by Anaerotruncus colihominis and emended description of the species
Investigator(s):Yuen KY, Lau SKP, Woo PCY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:09/2005


Project Title:Investigation of invasive Lasiodiplodia theobromae infections in humans
Investigator(s):Yuen KY, Tse H, Woo PCY, Lau SKP
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:09/2007


Project Title:Molecular epidemiological investigation of PARV-4-related viruses in HK and southern China
Investigator(s):Yuen KY, Tse H, Lau SKP, Woo PCY
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:10/2008


Project Title:Understanding the evolution and interspecies transmission of betacoronaviruses by structural and biophysical approaches
Investigator(s):Yuen KY, Woo PCY, Lau SKP, Chan JFW
Department:Microbiology
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2015
Completion Date:12/2018


Project Title:Control of viral and multidrug resistant bacterial infections relevant to Hong Kong SAR
Investigator(s):Yuen KY, Jin D, Lau SKP, To KKW, Chan JFW, Sze KH, Tse H, Woo PCY, Hung FNI, Huang J, Ho PL, Kao RYT, Cheng CCV
Department:Microbiology
Source(s) of Funding:Commissioned Research on Control of Infectious Diseases (Phase III)
Start Date:01/2015


Project Title:Research Output Prize (Faculty of Medicine)
Investigator(s):Yuen KY, Hung FNI, Zhang J, To KKW, Chan JFW, Chan TCI, Lau JY, Chen H, Chan KH
Department:Microbiology
Source(s) of Funding:Research Output Prize (in Faculty)
Start Date:11/2016


Project Title:Research and Development of a Rapid Diagnostics and Antiviral Targets
Investigator(s):Yuen KY
Department:Microbiology
Source(s) of Funding:Respiratory Virus Research Foundation Limited
Start Date:06/2017


Project Title:Prevention & Research of Emerging Infectious Viral Diseases
Investigator(s):Yuen KY
Department:Microbiology
Source(s) of Funding:Ministry of Science and Technology of The People's Republic of China (MOST)
Start Date:04/2018


List of Research Outputs

Bao S., Jia L., Zhou X., ZHANG Z., Wu W.L., Yu Z., NG G.C.T., Fan Y., Wong S.M., Huang S., To K.K.W., Yuen K.Y., Yeung M.L. and Song Y., Integrated analysis of mRNA-seq and miRNA-seq for host susceptibilities to influenza A (H7N9) infection in inbred mouse lines, Functional & Integrative Genomics. 2018, 18: 411-424.
CHEUNG P.H.H., Fung S.Y., Yuen K.Y., Chen H. and Jin D., Influenza A virus PB1-F2 protein suppresses IL-1β production from human macrophages by enhancing MAVS degradation, The American Society for Virology 37th Annual Meeting, University of Maryland, College Park, Maryland, USA, July 14-18, 2018.. 2018.
Chan J.F.W., Yuan S., Chu H., Ye Z., Wen L.R., Yan B., To K.K.W., Kao R.Y.T. and Yuen K.Y., Best Poster Award (1st place in the Young Investigator Category), The 32nd International Conference on Antiviral Research (ICAR 2019). 2019.
Chan J.F.W., Choi G.K.Y., Yip C.Y., ZHU Z., Chan K.H. and Yuen K.Y., Clinical, epidemiological, and molecular analyses of the largest dengue outbreak in Hong Kong in the last 15 years, European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 2019.
Chan J.F.W., Yuen K.Y. and Hung F.N.I., Commissioned study on conducting tests for Zika virus among asymptomatic people returning from the 2016 Olympic Games and Paralympic Games, Health Research Symposium 2019.
Chan J.F.W., Yuan S., Chu H., Ye Z., WEN L., Yan B., To K.K.W., Kao R.Y.T. and Yuen K.Y., Identification of Sterol Regulatory Element Binding Protein-Dependent Lipidomic Reprogramming as a Broad-Spectrum Antiviral Target, 32nd International Conference on Antiviral Research (ICAR). 2019.
Chan J.F.W., Yuan S., CHIK K.K.H., Yip C.Y., Tee K.M., Lai K.K., Kao R.Y.T. and Yuen K.Y., Repurposing novobiocin as a flavivirus protease inhibitor, 67th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2018). 2018.
Chan J.F.W., Chu H., YUEN T.T., Yuan S., ZHU Z. and Yuen K.Y., Targeting the endoplasmic reticulum stress signaling pathways as treatment options for Zika virus infection, 35th ASM Clinical Virology Symposium. 2019.
Chan J.F.W., TSANG O.L., ZOU Z., CHIK K.K.H., Yuan S., Chu H., Lau S.K.P. and Yuen K.Y., The Cellular Kinase Inhibitor OSU-03012 Inhibits Enterovirus 71 In Vitro, Annual Meeting of the Infectious Diseases Society of America, IDWeek 2018.
Cheng C.C.V., Wong S.C., Wong C.Y.S., Ho P.L. and Yuen K.Y., Control of Carbapenemase-producing Enterobacteriaceae: Beyond the Hospital, EClinicalMedicine. 2018, 6: 3-4.
Cheng C.C.V., Wong S.C., Wong S.C.Y. and Yuen K.Y., Directly observed hand hygiene – from healthcare workers to patients, Journal of Hospital Infection. 2019, 101: 380-382.
Cheng C.C.V., Wong S.C., Chen H.K.J., Wong C.Y.S. and Yuen K.Y., Mycobacterium chimaera -contaminated heater–cooler devices: the inner surface as the missing link?, Journal of Hospital Infection. 2018.
Cheng C.C.V., Wong S.C., Wong C.Y.S., Sridhar S., Yip C.Y., Chen H.K.J., Fung J., Chiu H.Y.K., Ho P.L., Chen S., Cheng B.W.C., Ho C.L., Lo C.M. and Yuen K.Y., Nosocomial transmission of hepatitis C virus in a liver transplant center in Hong Kong: implication of reusable blood collection tube holder as the vehicle for transmission, Infection Control & Hospital Epidemiology. 2018, 39: 1170-1177.
Cheng C.C.V., Wong S.C., Wong C.Y.S., Sridhar S., Yip C.Y., Chen H.K.J., Fung J., Chiu H.Y.K., Ho P.L., Chen S., Cheng B.W.C., Ho S.L., Lo C.M. and Yuen K.Y., Reusable blood collection tube holders are implicated in nosocomial hepatitis C virus transmission, Infection Control & Hospital Epidemiology. 2019, 40: 252-253.
Cheng C.C.V., Wong S.C., Cao H., Chen J.H.K., So S.Y.C., Wong S.C.Y., Sridhar S., Yuen K.Y. and Ho P.L., Whole-genome sequencing data-based modeling for the investigation of an outbreak of community-associated methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit in Hong Kong, European Journal of Clinical Microbiology & Infectious Diseases. 2019, 38: 563-573.
Chu H., Chan C.M., Zhang X., Wang Y., Yuan S., Zhou J., Au Yeung K.H.R., Sze K.H., Yang D., Shuai H.V., Hou Y., Li C., Zhao X., Poon K.M., Leung A.S.P., Yeung M.L., Yan J., Lu G., Jin D., Gao G.F., Chan J.F.W. and Yuen K.Y., Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells, Journal of Biological Chemistry. 2018, 293: 11709-11726.
Fung S.Y., Chan C.P., Zhu L., Yuen K.Y., Woo P.C.Y., Cai Z. and Jin D., Middle East respiratory syndrome coronavirus ORF4b protein targets cGAS-STING pathway of nucleic acid sensing., Keystone Symposium on “Framing the Response to Emerging Virus Infections“, Pokfulam, Hong Kong. 2018.
Guo Q., Chan J.F.W., Poon K.M., Wu S., Chan C.S., Hou L., Yip C.Y., Ren C., Cai J., Zhao M., Zhang J., Song X., Chan K.H., Wang B., Kok K.H., Wen Y., Yuen K.Y. and Chen W., Immunization With a Novel Human Type 5 Adenovirus-Vectored Vaccine Expressing the Premembrane and Envelope Proteins of Zika Virus Provides Consistent and Sterilizing Protection in Multiple Immunocompetent and Immunocompromised Animal Models, The Journal of Infectious Diseases. 2018, 218: 365-377.
Hung F.N.I., Wong D.K.H., Seto W.K.W., Fung J.Y.Y., Yuen K.Y. and Yuen R.M.F., A Double-Blind Randomized Controlled Trial of Intradermal Hepatitis B Vaccination with Topical Imiquimod in Subjects with Occult Hepatitis B Infection, HEPATOLOGY. WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018, 68: 255A-256A.
LING L., Wu T., To K.K.W., Cheung K.W., Lui K.O., NIU M., LAM K.S., Wang C.C., Li J., Wang H., Yuen K.Y. and Chen Z., Vedolizumab-mediated integrin α4β7 blockade does not control HIV-1SF162 rebound after combination antiretroviral therapy interruption in humanized mice, AIDS. 2019, 33: F1-F12.
Lam W.H., Sze K.H., Ke Y., Tse M.K., Zhang H., Woo P.C.Y., Lau S.K.P., Lau C.C.Y., Xu S., Lai P.M., Zhou T., Antonyuk S.V., Kao R.Y.T., Yuen K.Y. and Hao Q., Talaromyces marneffei Mp1 Protein, a Novel Virulence Factor, Carries Two Arachidonic Acid-Binding Domains To Suppress Inflammatory Responses in Hosts , Infection and Immunity. 2019, 87.
Lau S.K.P., Wong Y.M., Tsang C.C., Ahmed S.S., Au Yeung K.H.R., Yuen K.Y., Wernery U. and Woo P.C.Y., Discovery and sequence analysis of four deltacoronaviruses from birds in the Middle East reveal interspecies jumping with recombination as a potential mechanism for avian-to-avian and avian-to-mammalian transmission, Journal of Virology. 2018, 92: e00265-18.
Lau S.K.P., ZHAO S., Sridhar S., Yip C.Y., AW YONG K.L., Chow E.Y.Y., Cheung K.C.M., Hui R.W.H., Leung R.Y.H., Lai S.K., Wu A.K.L., To K.K.W., Woo P.C.Y. and Yuen K.Y., Molecular epidemiology of coxsackievirus A6 circulating in Hong Kong reveals common neurological manifestations and emergence of novel recombinant groups, Journal of Clinical Virology. 2018, 108: 43-49.
Lau S.K.P., Wong A.C.P., Zhang L., Luk H.K.H., Kwok J.S.L., Ahmed S.S., Cai J., Zhao P.S.H., Teng L.L., Tsui S.K.W., Yuen K.Y. and Woo P.C.Y., Novel Bat Alphacoronaviruses in Southern China Support Chinese Horseshoe Bats as an Important Reservoir for Potential Novel Coronaviruses, Viruses. 2019, 11: 423.
Lau S.K.P., Fan R.Y.Y., Luk H.K.H., Zhu L., Fung J., Li K.S.M., Wong W.Y.M., Ahmed S.S., Chan J.F.W., Kok K.H., Chan K.H., Wernery U., Yuen K.Y. and Woo P.C.Y., Replication of MERS and SARS coronaviruses in bat cells offers insights to their ancestral origins, Emerging Microbes & Infections. 2018, 7: 1-11.
Lee C.Y., Zhang J., Chu H., Li C., Zhu H., Mak W.W.N., Chen Y., Kok K.H., To K.K.W. and Yuen K.Y., H7N9 influenza A virus activation of necroptosis in human monocytes links innate and adaptive immune responses, Cell Death & Disease. 2019, 10.
Li C., To K.K.W., Zhang J., Lee C.Y., Zhu H., Mak W.N., Hung F.N.I. and Yuen K.Y., Co-stimulation With TLR7 Agonist Imiquimod and Inactivated Influenza Virus Particles Promotes Mouse B Cell Activation, Differentiation, and Accelerated Antigen Specific Antibody Production., Frontiers in Immunology. 2018, 9.
Liu L., Wei Q., Lin Q., Fang J., Wang H., Kwok H.Y., Tang H.Y., Nishiura K., Peng J., Wu T., Wu T., Cheung K.W., Chan K.H., Alvarez X., Qin C., Lackner A., Perlman S., Yuen K.Y. and Chen Z., Anti–spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection, JCI Insight. 2019, 4.
Liu W.J., Zou R., Hu Y., Zhao M., Quan C., Tan S., Luo K., Yuan J., Zheng H., Liu J., Liu M., Bi Y., Yan J., Zhu B., Wang D., Wu G., Liu L., Yuen K.Y., Gao G.F. and Liu Y., Clinical, immunological and bacteriological characteristics of H7N9 patients nosocomially co-infected by Acinetobacter Baumannii: a case control study, BMC Infectious Diseases. 2018, 18.
Lui S.L., Yap Y.H.D., Cheng C.C.V., Chan D.T.M. and Yuen K.Y., Clinical practice guidelines for the provision of renal service in Hong Kong: Infection Control in Renal Service, Nephrology. 2019, 24 Suppl 1: 98-129.
Lui W.Y., Yuen C.K., Li C., Wong W.M., Lui P.Y., Lin C.H., Chan K.H., Zhao H., Chen H., To K.K.W., Zhang J., Yuen K.Y. and Kok K.H., SMRT sequencing revealed the diversity and characteristics of defective interfering RNAs in influenza A (H7N9) virus infection, Emerging Microbes & Infections. 2019, 8: 662-674.
Mok B.W.Y., LIU H., Lau S.Y.P., Yuen K.Y. and Chen H., New role of the Influenza NS1 protein: Induction of miR-146a-5p for virus replication through epigenetic mechanism, Chromatin and Epigenetics EMBO WORKSHOP, 1 - 4 May, 2019, Heidelberg, Germany. 2019.
Rosa Duque J.A.I.M.E. .S., To K.K.W., Chiang A.K.S., Chan G.C.F., Poon W.S.R., Yuen K.Y., Ha S.Y. and Cheuk D.K.L., Candida Tropicalis renal microabscesses in a child with leukemia confirmed using nucleic acid amplification and recovery after prolonged antifungal and corticosteroid treatment, International Journal of Infectious Diseases. 2019, 81: 110-113.
Sridhar S., Cheng C.C.V., Wong S.C., Yip C.Y., Wu S., Lo A.W.I., Leung K.H., Mak W.N., Cai J., Li X., Chan J.F.W., Lau S.K.P., Woo P.C.Y., Lai W.M., Kwan T.H., Au T.W.K., Lo C.M., Wong C.Y.S. and Yuen K.Y., Donor-Derived Genotype 4 Hepatitis E Virus Infection, Hong Kong, China, 2018, Emerging Infectious Diseases. 2019, 25: 425-433.
Sridhar S., Chung T.W.H., Chan J.F.W., Cheng C.C.V., Lau S.K.P., Yuen K.Y. and Woo P.C.Y., Emergence of Cytomegalovirus Mononucleosis Syndrome Among Young Adults in Hong Kong Linked to Falling Seroprevalence: Results of a 14-Year Seroepidemiological Study, Open Forum Infectious Diseases. 2018, 5.
Sridhar S., Yip C.Y., Wu S., Cai J., Zhang J., Leung K.H., Chung T.W.H., Chan J.F.W., Chan W.M., Teng L.L., Au-Yeung R.K.H., Cheng C.C.V., Chen H., Lau S.K.P., Woo P.C.Y., Xia N.S., Lo C.M. and Yuen K.Y., Rat Hepatitis E Virus as Cause of Persistent Hepatitis after Liver Transplant, Emerging Infectious Diseases. 2018, 24: 2241-2250.
To K.K.W., Chan K.H., Ho J., Pang P.K.P., Ho D.T.Y., Chang A.C.H., Seng C.W., Yip C.C.Y., Cheng C.C.V., Hung F.N.I. and Yuen K.Y., Respiratory virus infection among hospitalized adult patients with or without clinically apparent respiratory infection: a prospective cohort study, Clinical Microbiology and Infection. 2019.
WONG L.Y.R., Lui P.Y., Siu K.L., Yeung M.L., Yuen K.S., Fung S.Y., Chan C.P., Woo P.C.Y., Yuen K.Y. and Jin D., Middle-East respiratory syndrome coronavirus ORF8b protein suppresses type I interferon production by interacting with HSP70, The American Society for Virology 37th Annual Meeting, University of Maryland, College Park, Maryland, USA, July 14-18, 2018.. 2018.
WONG L.Y.R., Ye Z., Lui P.Y., Siu K.L., Yeung M.L., Yuen K.S., Fung S.Y., Chan C.P., Cai Z., Woo P.C.Y., Yuen K.Y. and Jin D., Suppression of type I interferon production by Middle East respiratory syndrome coronavirus ORF8b accessory protein through interaction with HSP70 chaperone, Keystone Symposium on “Framing the Response to Emerging Virus Infections”, Pokfulam, Hong Kong. 2018.
Walker M.J., Brouwer S., Forde B.M., Worthing K.A., McIntyre L., Sundac L., Maloney S., Roberts L.W., Barnett T.C., Richter J., Cork A.J., Irwin A.D., You Y., Zhang J., Dougan G., Yuen K.Y., Nizet V., Beatson S.A., Grimwood K. and Davies M.R., Detection of Epidemic Scarlet Fever Group A Streptococcus in Australia , Clinical Infectious Diseases. 2019.
Wen L.R., Chu H., Wong H.Y.B., Wang D., Li C., Zhao X., Chiu M.C., Yuan S., Fan Y., Chen H., Zhou J. and Yuen K.Y., Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses, Emerging Microbes & Infections. New York, USA, NPG, 2018, 7.
Wong C.Y.S., Poon W.S.R., Foo C.H., Ngan A.H.Y., Tse H., Lam C.M.V., Leung H.Y., Wong C.P., Cheng C.C.V., Chen H.K.J. and Yuen K.Y., Novel selective medium for the isolation of corynebacterium kroppenstedtii from heavily colonised clinical specimens , Journal of Clinical Pathology. 2018, 71: 781-786.
Wong S.S.Y., Yip C.Y., Sridhar S., Leung K.H., Cheng A.K.W., Fung A.M.Y., Lam H.Y., Chan K.H., Chan J.F.W., Cheng C.C.V., Tang B.S.F. and Yuen K.Y., Comparative evaluation of a laboratory-developed real-time PCR assay and RealStar® Adenovirus PCR Kit for quantitative detection of human adenovirus, Virology Journal. 2018, 15.
Woo P.C.Y., Teng L.L., Bai R., Tang Y., Wong A.Y.P., Li K.S.M., Lam C.S.F., Fan R.Y.Y., Lau S.K.P. and Yuen K.Y., Novel Picobirnaviruses in Respiratory and Alimentary Tracts of Cattle and Monkeys with Large Intra- and Inter-Host Diversity, Viruses. 2019, 11: 574.
Yan B., Chu H., Yang D., Sze K.H., Lai P.M., Yuan S., Shuai H.V., Wang Y., Kao R.Y.T., Chan J.F.W. and Yuen K.Y., Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication, Viruses. 2019, 11: 73.
Yeung M.L., JIA L., Yip C.Y., Chan J.F.W., Teng L.L., Chan K.H., Cai J., ZHANG C., Zhang J., Wong L.W.M., Kok K.H., Lau S.K.P., Woo P.C.Y., Lo J.Y.C., Jin D., Shih S.R. and Yuen K.Y., Human tryptophanyl-tRNA synthetase is an IFN-γ–inducible entry factor for Enterovirus, Journal of Clinical Investigation. 2018, 128: 5163-5177.
Yuan S., Chan J.F.W., Ye Z.W., Wen L., Tsang T.G.W., Cao J., Huang J., Chan C.Y.C., Chik K.K.H., Choi G.K.Y., Cai J., Yin F., Chu H., Liang M., Jin D. and Yuen K.Y., Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus, Viruses. 2019, 11: 385.
Yuen K.Y., Award of the Gold Bauhinia Star 2018, Hong Kong SAR Government. 2018.
Yuen K.Y., Certificate of Degree of Doctor honoris causa, Macau University of Science and Technology . 2019.
Yuen K.Y., Faculty Outstanding Research Output Award, LKS Faculty of Medicine, HKU. 2019.
ZHU Z., Chu H., WEN L., Yuan S., CHIK K.K.H., YUEN T.T., Yip C.Y., WANG D., Zhou J., Yin F., Jin D., Kok K.H., Yuen K.Y. and Chan J.F.W., Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy, International Journal of Molecular Sciences. 2019, 20: 392.
Zhang J., ZHU H., Chen Y., LI C., Li C., Gozali L., Lee C.Y., To K.K.W., Hung F.N.I. and Yuen K.Y., Prostaglandin E2-mediated impairment of innate immune response to A(H1N1)pdm09 infection in diet-induced obese mice could be restored by paracetamol , Journal of Infectious Diseases. 2018.
Zhao H., To K.K.W., Chu H., Ding Q., Zhao X., Li C., Shuai H.V., Yuan S., Zhou J., Kok K.H., Jiang S. and Yuen K.Y., Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza, Nature Communications. 2018, 9.
Zhou J., WANG D., WONG H.Y.B., Chu H. and Yuen K.Y., Identification and characterization of GLDC as host susceptibility gene to severe influenza., EMBO Molecular Medicine. 2018.
Zhou P.S.H., Yip C.Y., Sridhar S., Chow W.N., To K.K.W., Chan K.H., Chan J.F.W., Cheng C.C.V., Yuen K.Y., Woo P.C.Y. and Lau S.K.P., Identification And Characteristics Of The Newly Emerged Subclades Of Enterovirus D68 Associated With Severe Respiratory/central Nervous System Infections In Hong Kong. Australia Society For Microbiology Annual Scientific Meeting 2018, (Brisbane, Australia). 2018.
Zhu H., Lee C.Y., Li C., Mak W.N., Chen Y., Chan K.H., Zhang J., Fung W.F., Zhang R.Q., Fung Y.F., Poon W.S.R., Lam J.Y., Tam S., Hung F.N.I., Chen H., Yuen K.Y. and To K.K.W., Low population serum microneutralization antibody titer against the predominating influenza A(H3N2) N121K virus during the severe influenza summer peak of Hong Kong in 2017, Emerging Microbes & Infections. New York, NPG, 2018, 7: 23.


Researcher : ZHANG C

List of Research Outputs

Yeung M.L., JIA L., Yip C.Y., Chan J.F.W., Teng L.L., Chan K.H., Cai J., ZHANG C., Zhang J., Wong L.W.M., Kok K.H., Lau S.K.P., Woo P.C.Y., Lo J.Y.C., Jin D., Shih S.R. and Yuen K.Y., Human tryptophanyl-tRNA synthetase is an IFN-γ–inducible entry factor for Enterovirus, Journal of Clinical Investigation. 2018, 128: 5163-5177.


Researcher : ZHANG X

List of Research Outputs

Chu H., Chan C.M., Zhang X., Wang Y., Yuan S., Zhou J., Au Yeung K.H.R., Sze K.H., Yang D., Shuai H.V., Hou Y., Li C., Zhao X., Poon K.M., Leung A.S.P., Yeung M.L., Yan J., Lu G., Jin D., Gao G.F., Chan J.F.W. and Yuen K.Y., Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells, Journal of Biological Chemistry. 2018, 293: 11709-11726.
Zhang K., Li C., Luo Y.S., Wen L.R., Yuan S., Wang D., WONG H.Y.B., Zhao X., Chiu M.C., Ye Z., Sun Z., Zhao H., ZHANG X., Hu M., Yang D., Shuai H.V., Wang Y., He J., Bose M.E., Henrickson K.J., Huang J., Zheng B., Chu H. and Zhou J., Establishment of a lethal aged mouse model of human respiratory syncytial virus infection, Antiviral Research. 2019, 161: 125-133.


Researcher : ZHAO S

List of Research Outputs

Lau S.K.P., ZHAO S., Sridhar S., Yip C.Y., AW YONG K.L., Chow E.Y.Y., Cheung K.C.M., Hui R.W.H., Leung R.Y.H., Lai S.K., Wu A.K.L., To K.K.W., Woo P.C.Y. and Yuen K.Y., Molecular epidemiology of coxsackievirus A6 circulating in Hong Kong reveals common neurological manifestations and emergence of novel recombinant groups, Journal of Clinical Virology. 2018, 108: 43-49.


Researcher : ZHU Z

List of Research Outputs

Chan J.F.W., Choi G.K.Y., Yip C.Y., ZHU Z., Chan K.H. and Yuen K.Y., Clinical, epidemiological, and molecular analyses of the largest dengue outbreak in Hong Kong in the last 15 years, European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 2019.
Chan J.F.W., Chu H., YUEN T.T., Yuan S., ZHU Z. and Yuen K.Y., Targeting the endoplasmic reticulum stress signaling pathways as treatment options for Zika virus infection, 35th ASM Clinical Virology Symposium. 2019.
ZHU Z., Chu H., WEN L., Yuan S., CHIK K.K.H., YUEN T.T., Yip C.Y., WANG D., Zhou J., Yin F., Jin D., Kok K.H., Yuen K.Y. and Chan J.F.W., Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy, International Journal of Molecular Sciences. 2019, 20: 392.


Researcher : ZOU Z

List of Research Outputs

Chan J.F.W., TSANG O.L., ZOU Z., CHIK K.K.H., Yuan S., Chu H., Lau S.K.P. and Yuen K.Y., The Cellular Kinase Inhibitor OSU-03012 Inhibits Enterovirus 71 In Vitro, Annual Meeting of the Infectious Diseases Society of America, IDWeek 2018.


Researcher : Zhang H

Project Title:the 1st european conference of microbiology and immunology Low Th17 expression association with Chronic Hepatitis B viral infection by means of reducing viral specific IFNγ releasing in a HBV infection model of IL-17 KO mice
Investigator(s):Zhang H
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:05/2011




Researcher : Zhang J

Project Title:Modulation of prostaglandin E2 and lipoxins to ameliorate the severe lung inflammation induced by A(H1N1)pdm09 influenza virus in diet induced obese mice
Investigator(s):Zhang J, To KKW, Zheng B
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:05/2016
Completion Date:10/2019


Project Title:6th International conference and exbition on Natural Products Chemistry and Medicinal Plants Research; Cinnamon crude extract neutralizing influenza virus by blocking virus binding and entry into the host cells
Investigator(s):Zhang J
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2019
Completion Date:06/2019


List of Research Outputs

Guo Q., Chan J.F.W., Poon K.M., Wu S., Chan C.S., Hou L., Yip C.Y., Ren C., Cai J., Zhao M., Zhang J., Song X., Chan K.H., Wang B., Kok K.H., Wen Y., Yuen K.Y. and Chen W., Immunization With a Novel Human Type 5 Adenovirus-Vectored Vaccine Expressing the Premembrane and Envelope Proteins of Zika Virus Provides Consistent and Sterilizing Protection in Multiple Immunocompetent and Immunocompromised Animal Models, The Journal of Infectious Diseases. 2018, 218: 365-377.
Lee C.Y., Zhang J., Chu H., Li C., Zhu H., Mak W.W.N., Chen Y., Kok K.H., To K.K.W. and Yuen K.Y., H7N9 influenza A virus activation of necroptosis in human monocytes links innate and adaptive immune responses, Cell Death & Disease. 2019, 10.
Li C., To K.K.W., Zhang J., Lee C.Y., Zhu H., Mak W.N., Hung F.N.I. and Yuen K.Y., Co-stimulation With TLR7 Agonist Imiquimod and Inactivated Influenza Virus Particles Promotes Mouse B Cell Activation, Differentiation, and Accelerated Antigen Specific Antibody Production., Frontiers in Immunology. 2018, 9.
Lui W.Y., Yuen C.K., Li C., Wong W.M., Lui P.Y., Lin C.H., Chan K.H., Zhao H., Chen H., To K.K.W., Zhang J., Yuen K.Y. and Kok K.H., SMRT sequencing revealed the diversity and characteristics of defective interfering RNAs in influenza A (H7N9) virus infection, Emerging Microbes & Infections. 2019, 8: 662-674.
Sridhar S., Yip C.Y., Wu S., Cai J., Zhang J., Leung K.H., Chung T.W.H., Chan J.F.W., Chan W.M., Teng L.L., Au-Yeung R.K.H., Cheng C.C.V., Chen H., Lau S.K.P., Woo P.C.Y., Xia N.S., Lo C.M. and Yuen K.Y., Rat Hepatitis E Virus as Cause of Persistent Hepatitis after Liver Transplant, Emerging Infectious Diseases. 2018, 24: 2241-2250.
Yeung M.L., JIA L., Yip C.Y., Chan J.F.W., Teng L.L., Chan K.H., Cai J., ZHANG C., Zhang J., Wong L.W.M., Kok K.H., Lau S.K.P., Woo P.C.Y., Lo J.Y.C., Jin D., Shih S.R. and Yuen K.Y., Human tryptophanyl-tRNA synthetase is an IFN-γ–inducible entry factor for Enterovirus, Journal of Clinical Investigation. 2018, 128: 5163-5177.
Zhang J., ZHU H., Chen Y., LI C., Li C., Gozali L., Lee C.Y., To K.K.W., Hung F.N.I. and Yuen K.Y., Prostaglandin E2-mediated impairment of innate immune response to A(H1N1)pdm09 infection in diet-induced obese mice could be restored by paracetamol , Journal of Infectious Diseases. 2018.
Zhu H., Lee C.Y., Li C., Mak W.N., Chen Y., Chan K.H., Zhang J., Fung W.F., Zhang R.Q., Fung Y.F., Poon W.S.R., Lam J.Y., Tam S., Hung F.N.I., Chen H., Yuen K.Y. and To K.K.W., Low population serum microneutralization antibody titer against the predominating influenza A(H3N2) N121K virus during the severe influenza summer peak of Hong Kong in 2017, Emerging Microbes & Infections. New York, NPG, 2018, 7: 23.


Researcher : Zhang JX

Project Title:Modulation of prostaglandin E2 and lipoxins to ameliorate the severe lung inflammation induced by A(H1N1)pdm09 influenza virus in diet induced obese mice
Investigator(s):Zhang J, To KKW, Zheng B
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:05/2016
Completion Date:10/2019


Project Title:6th International conference and exbition on Natural Products Chemistry and Medicinal Plants Research; Cinnamon crude extract neutralizing influenza virus by blocking virus binding and entry into the host cells
Investigator(s):Zhang J
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2019
Completion Date:06/2019


List of Research Outputs



Researcher : Zhang K

List of Research Outputs

Zhang K., Li C., Luo Y.S., Wen L.R., Yuan S., Wang D., WONG H.Y.B., Zhao X., Chiu M.C., Ye Z., Sun Z., Zhao H., ZHANG X., Hu M., Yang D., Shuai H.V., Wang Y., He J., Bose M.E., Henrickson K.J., Huang J., Zheng B., Chu H. and Zhou J., Establishment of a lethal aged mouse model of human respiratory syncytial virus infection, Antiviral Research. 2019, 161: 125-133.


Researcher : Zhang M

Project Title:Development of a "Two-in-One" Duel Specific Antibody Therapeutics for Treatment of Breast Cancer
Investigator(s):Zhang M
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:11/2011




Researcher : Zhang X

List of Research Outputs

Chu H., Chan C.M., Zhang X., Wang Y., Yuan S., Zhou J., Au Yeung K.H.R., Sze K.H., Yang D., Shuai H.V., Hou Y., Li C., Zhao X., Poon K.M., Leung A.S.P., Yeung M.L., Yan J., Lu G., Jin D., Gao G.F., Chan J.F.W. and Yuen K.Y., Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells, Journal of Biological Chemistry. 2018, 293: 11709-11726.
Zhang K., Li C., Luo Y.S., Wen L.R., Yuan S., Wang D., WONG H.Y.B., Zhao X., Chiu M.C., Ye Z., Sun Z., Zhao H., ZHANG X., Hu M., Yang D., Shuai H.V., Wang Y., He J., Bose M.E., Henrickson K.J., Huang J., Zheng B., Chu H. and Zhou J., Establishment of a lethal aged mouse model of human respiratory syncytial virus infection, Antiviral Research. 2019, 161: 125-133.


Researcher : Zhao H

List of Research Outputs

Lui W.Y., Yuen C.K., Li C., Wong W.M., Lui P.Y., Lin C.H., Chan K.H., Zhao H., Chen H., To K.K.W., Zhang J., Yuen K.Y. and Kok K.H., SMRT sequencing revealed the diversity and characteristics of defective interfering RNAs in influenza A (H7N9) virus infection, Emerging Microbes & Infections. 2019, 8: 662-674.
Zhang K., Li C., Luo Y.S., Wen L.R., Yuan S., Wang D., WONG H.Y.B., Zhao X., Chiu M.C., Ye Z., Sun Z., Zhao H., ZHANG X., Hu M., Yang D., Shuai H.V., Wang Y., He J., Bose M.E., Henrickson K.J., Huang J., Zheng B., Chu H. and Zhou J., Establishment of a lethal aged mouse model of human respiratory syncytial virus infection, Antiviral Research. 2019, 161: 125-133.
Zhao H., To K.K.W., Chu H., Ding Q., Zhao X., Li C., Shuai H.V., Yuan S., Zhou J., Kok K.H., Jiang S. and Yuen K.Y., Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza, Nature Communications. 2018, 9.


Researcher : Zhao X

List of Research Outputs

Chu H., Chan C.M., Zhang X., Wang Y., Yuan S., Zhou J., Au Yeung K.H.R., Sze K.H., Yang D., Shuai H.V., Hou Y., Li C., Zhao X., Poon K.M., Leung A.S.P., Yeung M.L., Yan J., Lu G., Jin D., Gao G.F., Chan J.F.W. and Yuen K.Y., Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells, Journal of Biological Chemistry. 2018, 293: 11709-11726.
Wen L.R., Chu H., Wong H.Y.B., Wang D., Li C., Zhao X., Chiu M.C., Yuan S., Fan Y., Chen H., Zhou J. and Yuen K.Y., Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses, Emerging Microbes & Infections. New York, USA, NPG, 2018, 7.
Zhang K., Li C., Luo Y.S., Wen L.R., Yuan S., Wang D., WONG H.Y.B., Zhao X., Chiu M.C., Ye Z., Sun Z., Zhao H., ZHANG X., Hu M., Yang D., Shuai H.V., Wang Y., He J., Bose M.E., Henrickson K.J., Huang J., Zheng B., Chu H. and Zhou J., Establishment of a lethal aged mouse model of human respiratory syncytial virus infection, Antiviral Research. 2019, 161: 125-133.
Zhao H., To K.K.W., Chu H., Ding Q., Zhao X., Li C., Shuai H.V., Yuan S., Zhou J., Kok K.H., Jiang S. and Yuen K.Y., Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza, Nature Communications. 2018, 9.


Researcher : Zheng B

Project Title:Study of vaccine HA-M2 against H5N1 avian influenza virus
Investigator(s):Zheng B
Department:Microbiology
Source(s) of Funding:Matching Fund for Hi-Tech Research and Development Program of China (863 Projects)
Start Date:08/2007


Project Title:Development of Antiviral Agents based on Small RNA Containing Unique Motif (UIM/215)
Investigator(s):Zheng B, Zhou J
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:05/2012


Project Title:Development of Antiviral Peptides against Infections of Influenza Virus and Other Respiratory Viruses
Investigator(s):Zheng B, Zhou J
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:11/2013


Project Title:Identification of ADCC epitopes on Hemagglutinin Antigen of Pandemic H1N1 Influenza Virus for Vaccine Development
Investigator(s):Zheng B, Chu H
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:03/2015


Project Title:Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase
Investigator(s):Zheng B, Kao RYT, Zhou J
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:09/2015


Project Title:Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase
Investigator(s):Zheng B, Kao RYT, Zhou J
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:09/2015


Project Title:Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase
Investigator(s):Zheng B, Kao RYT, Zhou J
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:09/2015


List of Research Outputs

Zhang K., Li C., Luo Y.S., Wen L.R., Yuan S., Wang D., WONG H.Y.B., Zhao X., Chiu M.C., Ye Z., Sun Z., Zhao H., ZHANG X., Hu M., Yang D., Shuai H.V., Wang Y., He J., Bose M.E., Henrickson K.J., Huang J., Zheng B., Chu H. and Zhou J., Establishment of a lethal aged mouse model of human respiratory syncytial virus infection, Antiviral Research. 2019, 161: 125-133.


Researcher : Zheng B.

Project Title:Study of vaccine HA-M2 against H5N1 avian influenza virus
Investigator(s):Zheng B
Department:Microbiology
Source(s) of Funding:Matching Fund for Hi-Tech Research and Development Program of China (863 Projects)
Start Date:08/2007


Project Title:Development of Antiviral Agents based on Small RNA Containing Unique Motif (UIM/215)
Investigator(s):Zheng B, Zhou J
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:05/2012


Project Title:Development of Antiviral Peptides against Infections of Influenza Virus and Other Respiratory Viruses
Investigator(s):Zheng B, Zhou J
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:11/2013


Project Title:Identification of ADCC epitopes on Hemagglutinin Antigen of Pandemic H1N1 Influenza Virus for Vaccine Development
Investigator(s):Zheng B, Chu H
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:03/2015


Project Title:Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase
Investigator(s):Zheng B, Kao RYT, Zhou J
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:09/2015


Project Title:Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase
Investigator(s):Zheng B, Kao RYT, Zhou J
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:09/2015


Project Title:Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase
Investigator(s):Zheng B, Kao RYT, Zhou J
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:09/2015


List of Research Outputs



Researcher : Zhou J

Project Title:A cell-based model to uncover the molecular underpinning of differential susceptibility and variable severity of human H7N9 influenza infection
Investigator(s):Zhou J, Song Y, To KKW
Department:Microbiology
Source(s) of Funding:Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential
Start Date:08/2014


Project Title:Characterization of the immune activation pathway in human macrophage and the macrophage-neutrophil interaction in MERS coronavirus infection
Investigator(s):Zhou J, Jin D, Chan JFW
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:07/2015


Project Title:Establishing Functional Human Lung Organoids to Recapitulate and Study Viral Growth and Virus-Host Interaction of Avian Influenza A Viruses
Investigator(s):Zhou J, Chen H, Chu H
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:07/2018


Project Title:Stem Cells & Organoids in Development & Diseases; Differentiated human airway organoids for assessing infectivity of influenza virus
Investigator(s):Zhou J
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:02/2019
Completion Date:02/2019


List of Research Outputs

Chu H., Chan C.M., Zhang X., Wang Y., Yuan S., Zhou J., Au Yeung K.H.R., Sze K.H., Yang D., Shuai H.V., Hou Y., Li C., Zhao X., Poon K.M., Leung A.S.P., Yeung M.L., Yan J., Lu G., Jin D., Gao G.F., Chan J.F.W. and Yuen K.Y., Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells, Journal of Biological Chemistry. 2018, 293: 11709-11726.
Wen L.R., Chu H., Wong H.Y.B., Wang D., Li C., Zhao X., Chiu M.C., Yuan S., Fan Y., Chen H., Zhou J. and Yuen K.Y., Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses, Emerging Microbes & Infections. New York, USA, NPG, 2018, 7.
ZHU Z., Chu H., WEN L., Yuan S., CHIK K.K.H., YUEN T.T., Yip C.Y., WANG D., Zhou J., Yin F., Jin D., Kok K.H., Yuen K.Y. and Chan J.F.W., Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy, International Journal of Molecular Sciences. 2019, 20: 392.
Zhang K., Li C., Luo Y.S., Wen L.R., Yuan S., Wang D., WONG H.Y.B., Zhao X., Chiu M.C., Ye Z., Sun Z., Zhao H., ZHANG X., Hu M., Yang D., Shuai H.V., Wang Y., He J., Bose M.E., Henrickson K.J., Huang J., Zheng B., Chu H. and Zhou J., Establishment of a lethal aged mouse model of human respiratory syncytial virus infection, Antiviral Research. 2019, 161: 125-133.
Zhao H., To K.K.W., Chu H., Ding Q., Zhao X., Li C., Shuai H.V., Yuan S., Zhou J., Kok K.H., Jiang S. and Yuen K.Y., Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza, Nature Communications. 2018, 9.
Zhou J., WANG D., WONG H.Y.B., Chu H. and Yuen K.Y., Identification and characterization of GLDC as host susceptibility gene to severe influenza., EMBO Molecular Medicine. 2018.


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