Dept of Clinical Oncology

DEPT OF CLINICAL ONCOLOGY

Researcher : CHEN J

List of Research Outputs

JIANG C., CHEN J., Xie S., Zhang L., Xiang Y., Lung M.L., Kam N.W., Kwong D.L.W., Cao S. and Guan X., Evaluation of circulating EBV microRNA BART2-5p in facilitating early detection and screening of nasopharyngeal carcinoma, International Journal of Cancer. 2018.

Tang H., Jiang L., Zhu C., Liu W.M.R., Wu Y., Yan Q., Liu M., Jia Y., Chen J., Qin Y., Lee V.H.F., Luo S., Wang Q. and Guan X., Loss of cell adhesion molecule L1 like promotes tumor growth and metastasis in esophageal squamous cell carcinoma, Oncogene. 2019.

Researcher : CHOI SS.A

List of Research Outputs

CHOI S.S...A., Dai W., Yu V.Z.Y., Ko J.M.Y. and Lung M.L., Functional Characterization of ZNF750 in esophageal squamous cell carcinoma., 110th American Association Cancer Research Annual Meeting, Atlanta, Georgia, USA. March 29- April 3, 2019.. 2019.

Researcher : CUI Y

List of Research Outputs

Fang S., Liu M., Li L., ZHANG F., Li Y., CUI Y., Zhu Y.H., Yuan Y.F. and Guan X., Lymphoid enhancer-binding factor-1 promotes stemness and poor differentiation of hepatocellular carcinoma by directly activating the NOTCH pathway, Oncogene. 2019, 38(21): 4061-4074.

Researcher : Chan KC

List of Research Outputs

Chan L.S., Man O.Y., Kwok H.H., Chen L., Chan K.C., Lung H.L., Ngan K.C.R., Wong R.N.S., Lo K.W., Lee W.M.A., Tsao G.S.W., Kahn M., Lung M.L. and Mak N.K., The Wnt modulator ICG‑001 mediates the inhibition of nasopharyngeal carcinoma cell migration in vitro via the miR‑150/CD44 axis., Int J Oncol.. 2018, 54(3): 1010-1020.

Ko J.M.Y., Vardhanabhuti V., Ng W.T., Lam K.O., Ngan K.C.R., Kwong D.L.W., Lee V.H.F., Lui Y.H., Yau C.C., Kwan C.K., Li W.S., Yau S., Guo C., Choi S.S.A., Lei C.L., Chan K.C., Lam C.S.C., Chang C.K.C., Dai W., Khong P.L. and Lung M.L., In: Gordon Research Conference on Translational Cancer Genomics. Hong Kong. June 30-July 5, 2019., Complementary role of circulating tumor cell and cfDNA improves detection of minimal residual disease in metastatic nasopharyngeal carcinoma.. 2019.

Researcher : Chan SK

List of Research Outputs

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., O'Sullivan B., Lam K.O., Lai V., Khong P.L., Chan S.K., Ng C.Y., Tong C.C., Ho P.Y.P., Chan W.L.W., Wong L.S., Leung D.K.C., Chan S.Y., So T.H., Luk M.Y. and Lee W.M.A., The addition of pretreatment plasma Epstein-Barr virus DNA into the 8th edition of nasopharyngeal cancer TNM stage classification, International Journal of Cancer. 2018.

So T.H., Chan S.K., Lee V.H.F., Chen B.Z., Kong F.P. and Lao L., Chinese Medicine in Cancer Treatment -How is it Practiced in the East and the West?, Clinical Oncology . 2019, 31: 578–588.

Researcher : Chan WLW

List of Research Outputs

Chan W.L.W. and Lam K.O., Management of Advanced Gastric Cancer, The Hong Kong Medical Diary. 2018.

Lam K.O., Chan W.L.W., So T.H., Lee V.H.F. and Kwong D.L.W., Third-line Systemic Treatment In Advanced/metastatic Gastric Cancer: A Comprehensive Review., Ther Adv Med Oncol. 2019.

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., O'Sullivan B., Lai V., Tong C.C., Lam K.O., Ng C.Y., Chan S.Y., Ho P.Y.P., Chan W.L.W., Leung D.K., Chan S.K., Tsang K.C., Khong P.L., Luk M.Y. and Lee W.M.A., 5-Year Results of the Prognostic Roles of Serial Post-Intensity-Modulated Radiation Therapy Undetectable Plasma EBV DNA for Non-Metastatic Nasopharyngeal Carcinoma, International Journal of Radiation Oncology*Biology*Physics. 2018, 102: S126-S127.

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., O'Sullivan B., Lam K.O., Lai V., Khong P.L., Chan S.K., Ng C.Y., Tong C.C., Ho P.Y.P., Chan W.L.W., Wong L.S., Leung D.K.C., Chan S.Y., So T.H., Luk M.Y. and Lee W.M.A., The addition of pretreatment plasma Epstein-Barr virus DNA into the 8th edition of nasopharyngeal cancer TNM stage classification, International Journal of Cancer. 2018.

Wong Y.H.I., Lam K.O., Chan W.L.W., Wong L.Y.C., So T.H., Chan K.K.D., Choi C.W., Law T.T., Chiu W.H.K., Chan S.Y., Kwong D.L.W. and Law S.Y.K., Real World Scenario: CROSS regimen as preoperative therapy for esophageal squamous cell carcinoma (Abstract), SSAT Plenary Session: Esophagus and Gastric II, Digestive Disease Week (DDW 2019), San Diego, USA, 18-21 May. 2019.

Researcher : Chang TYA

Project Title:	A multi-institutional study comparing clinical outcome and toxicities of novel image guided brachytherapy with conventional techniques for locally advanced cervical cancer in Hong Kong
Investigator(s):	Chang TYA, Ngan KCR, Chan KKL, Choi CW, Siu WKS
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2019

List of Research Outputs

Lee V.H.F., Lam K.O., Chang T.Y.A., Lam T.C., Chiang C.L., So T.H., Choi C.W. and Lee W.M.A., Management of Nasopharyngeal Carcinoma: Is Adjuvant Therapy Needed?, Journal of Oncology Practice. 2018, 14: 594-602.

Researcher : Cheng CK

List of Research Outputs

Hou W.K., Lau K.M., Shum C.Y.T., Cheng C.K. and Lee T.M.C., Do concordances of social support and relationship quality predict psychological distress and well-being of cancer patients and caregivers?, European Journal of Cancer Care. 2018, 27: e12857.

Researcher : Cheung AKL

Project Title:	Investigation of the role of Epstein-Barr Virus in epigenetic regulation in nasopharyngeal carcinoma
Investigator(s):	Cheung AKL, Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2012

List of Research Outputs

DENG M., Cheung A.K.L., Dai W., Yu V.Z.Y. and Lung M.L., In: 110th American Association Cancer Research Annual Meeting, Atlanta, Georgia, USA. March 29- April 3, 2019., Functional and molecular analysis of the somatic mutations in NF-ĸB pathway inhibitor, CYLD, in nasopharyngeal carcinoma.. 2019.

LEONG M.L., Cheung A.K.L., Dai W., Tsao G.S.W. and Lung M.L., EBV-associated histone modifications in the regulation of DNA damage repair members resulting in cisplatin resistance in nasopharyngeal carcinoma, The 77th Annual Meeting of the Japanese Cancer Association. Osaka, Japan, Sept 27-29, 2018.

Leong M.L., Cheung A.K.L., Dai W., Tsao G.S.W., Dawson C.W. and Lung M.L., EBV modulates histone H3K4me3 and H3K27me3 bivalent switch to suppress DNA damage repair pathway members in epithelial cells., PNAS 2019. 2019.

Leong M.L., Cheung A.K.L., Dai W., Tsao G.S.W. and Lung M.L., EBV-associated bivalent histone modifications regulate DNA damage repair and cisplatin resistance in epithelial malignancy., 110th American Association Cancer Research Annual Meeting, Atlanta, Georgia, USA. March 29- April 3, 2019.. 2019.

Researcher : Chiang CL

Project Title:	Treatment outcomes in regractory mCRC patients
Investigator(s):	Chiang CL, Lam KO
Department:	Clinical Oncology
Source(s) of Funding:	Bayer HealthCare Limited
Start Date:	04/2017

Project Title:	ASTRO's 59th Annual Meeting; Albumin-Bilirubin (ALBI) versus Child-Pugh (CP) Score as a predictor of survival after Stereotactic Body Radiotherapy (SBRT) in Hepatocellular Carcinoma (HCC)
Investigator(s):	Chiang CL
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2017

Project Title:	Prospective Multi-center Single Arm Phase II Trial of External Radiotherapy plus Endorectal Brachytherapy Boost as Radical Treatment in Rectal Cancer Patients
Investigator(s):	Chiang CL, Lam KO, Foo CC, Chiu WHK, Choi CW
Department:	Clinical Oncology
Source(s) of Funding:	Seed Fund for Basic Research for New Staff
Start Date:	01/2018

Project Title:	Cost-effectiveness of anti-EGFR antibodies as first-line treatment in RAS wild type (WT) metastatic colorectal cancer (mCRC) in Hong Kong
Investigator(s):	Chiang CL, Choi CW, Lam KO, Lee VHF, Wong OL
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Mini Grant
Start Date:	04/2018

Project Title:	Sequential TransArterial chemoembolization and stereotactic RadioTherapy followed by ImmunoTherapy for downstaging heapatocellular carcinoma for hepatectomy (START-FIT)
Investigator(s):	Chiang CL, Chan ACY, Lam TC
Department:	Clinical Oncology
Source(s) of Funding:	Merck Pharmaceutical (HK) Ltd
Start Date:	02/2019

Project Title:	Radiosensitivity index (RSI) as predictive biomarker for radiotherapy de-intensification in nasopharyngeal carcinoma
Investigator(s):	Chiang CL, Lee WMA, Choi CW, Ngan KCR, Lee VHF, Lam TC, Lam KO, Tsang KC, Wong WHJ
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2019

List of Research Outputs

Chan K.H., Lee R.W., Lee V.W., Wong M.Y., Chiang C.L., Law G.M. and Blanck O., Linking dose delivery accuracy and planning target margin in radiosurgery based on dose-volume histograms derived from measurement-guided dose reconstruction, Phys Med Biol. 2019.

Chan M.K., Lee V.W., Kadoya N., Chiang C.L., Wong M.Y., Leung R.W., Cheung S. and Blanck O., Single fraction computed tomography-guided high-dose-rate brachytherapy or stereotactic body radiotherapy for primary and metastatic lung tumors?, J Contemp Brachytherapy. 2018.

Chiang C.L., ASCO Updates on Immunotherapy in Liver Cancer: What Surgeons need to know. , Hong Kong Surgical Forum 2019 . 2019.

Chiang C.L., Ng W.T., Chang A., Kam M., Au K.H. and Sze H., Advances in Radiotherapy, Nasopharyngeal Carcinoma (1st Edition): From Etiology to Clinical Practice . Elsevier, 2019, 263-279.

Chiang C.L., Clinical Trial Workshop Concept Presentation, International Oncology Symposium on Advances in Immuno-Oncology, Radiation and Clinical Trials, Shenzhen, China . 2019.

Chiang C.L., Chan M.H.K. and Yeung C.S.Y., Combined stereotactic body radiotherapy and trans-arterial chemoembolization as initial treatment in BCLC stage B-C hepatocellular carcinoma., Strahlenther Onkol. 2018.

Chiang C.L., Current Perspective of SBRT in Liver and Pancreatic Cancer, 26th Annual Scientific Meeting of Hong Kong College of Radiologists. 2018.

Chiang C.L., Current Perspective on SBRT and Chemotherapy for Pancreatic Adenocarcinoma, Hong Kong Society of Hepato-biliary and Pancreatic Surgery 8th Annual Scientific Meeting. 2019.

Chiang C.L., Current Perspective on SBRT and chemotherapy for pancreatic cancer, HBP multi-disciplinary board meeting, Conde S. Januário Hospital, Macau. 2019.

Chiang C.L., Palliative Liver Radiotherapy (RT) of Advanced Hepatocellular Carcinoma (HCC) in Endemic Population, ESTRO 2019 (26-Apr-2019), Milan, Italy . 2019.

Chiang C.L., Prognostic Factors in Advanced Hepatocellular Carcinoma (HCC) of 10cmTreated with Stereotactic Body Radiotherapy (SBRT), 10th Asia-Pacific Primary Liver Cancer Expert Congress (APPLE 2019). 2019.

Chiang C.L., Lam K.O., Chan H.C., Chan B.Y., Lee S.F., Yeung S.Y., Lau K.S., Chan S.Y., Choy T.S. and Yuen K.K., Real‐world treatment patterns and outcomes in refractory metastatic colorectal cancer, Asia-Pacific Journal of Clinical Oncology. 2019.

Chiang C.L., The Role of Immunotherapy in HCC, The China-Hong Kong HCC Scientific Exchange Meeting. 2019.

Chiang C.L., 放射治療於肝癌的應用, In: CL Chiang , 粵港澳大灣區腫瘤高峰論壇暨第十屆番禺腫瘤論壇, 2018.

Lee V.H.F., Lam K.O., Chang T.Y.A., Lam T.C., Chiang C.L., So T.H., Choi C.W. and Lee W.M.A., Management of Nasopharyngeal Carcinoma: Is Adjuvant Therapy Needed?, Journal of Oncology Practice. 2018, 14: 594-602.

Wong C.L.T., Chiang C.L., Lee A.S., Lee V.H.F., Yeung C.S.Y., Ho C.H.M., Cheung T.T., Ng K.C.K., Chok K.S.H., Chan A.C.Y., Dai W.C., Wong F.C.S., Luk M.Y., Leung T.W. and Lo C.M., Better survival after stereotactic body radiation therapy following transarterial chemoembolization in nonresectable hepatocellular carcinoma: A propensity score matched analysis, Surgical Oncology. 2019, 28: 228-235.

Researcher : Choi CW

List of Research Outputs

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., O'Sullivan B., Lai V., Tong C.C., Lam K.O., Ng C.Y., Chan S.Y., Ho P.Y.P., Chan W.L.W., Leung D.K., Chan S.K., Tsang K.C., Khong P.L., Luk M.Y. and Lee W.M.A., 5-Year Results of the Prognostic Roles of Serial Post-Intensity-Modulated Radiation Therapy Undetectable Plasma EBV DNA for Non-Metastatic Nasopharyngeal Carcinoma, International Journal of Radiation Oncology*Biology*Physics. 2018, 102: S126-S127.

Lee V.H.F., Lam K.O., Chang T.Y.A., Lam T.C., Chiang C.L., So T.H., Choi C.W. and Lee W.M.A., Management of Nasopharyngeal Carcinoma: Is Adjuvant Therapy Needed?, Journal of Oncology Practice. 2018, 14: 594-602.

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., O'Sullivan B., Lam K.O., Lai V., Khong P.L., Chan S.K., Ng C.Y., Tong C.C., Ho P.Y.P., Chan W.L.W., Wong L.S., Leung D.K.C., Chan S.Y., So T.H., Luk M.Y. and Lee W.M.A., The addition of pretreatment plasma Epstein-Barr virus DNA into the 8th edition of nasopharyngeal cancer TNM stage classification, International Journal of Cancer. 2018.

Lee W.M.A., Zong J.F., Pam J.J., Choi C.W. and Sze H.C.K., Staging of Nasopharyngeal Carcinoma Based on the 8th Edition of the AJCC/UICC Staging System, Nasopharyngeal Carcinoma. Elsevier, 2019, 179-203.

Wong Y.H.I., Lam K.O., Chan W.L.W., Wong L.Y.C., So T.H., Chan K.K.D., Choi C.W., Law T.T., Chiu W.H.K., Chan S.Y., Kwong D.L.W. and Law S.Y.K., Real World Scenario: CROSS regimen as preoperative therapy for esophageal squamous cell carcinoma (Abstract), SSAT Plenary Session: Esophagus and Gastric II, Digestive Disease Week (DDW 2019), San Diego, USA, 18-21 May. 2019.

Researcher : Choi SSA

List of Research Outputs

Ko J.M.Y., Vardhanabhuti V., Ng W.T., Lam K.O., Ngan K.C.R., Kwong D.L.W., Lee V.H.F., Lui Y.H., Yau C.C., Kwan C.K., Li W.S., Yau S., Guo C., Choi S.S.A., Lei C.L., Chan K.C., Lam C.S.C., Chang C.K.C., Dai W., Khong P.L. and Lung M.L., In: Gordon Research Conference on Translational Cancer Genomics. Hong Kong. June 30-July 5, 2019., Complementary role of circulating tumor cell and cfDNA improves detection of minimal residual disease in metastatic nasopharyngeal carcinoma.. 2019.

Researcher : Chua DTT

Project Title:	2000 Annual Meeting of the American Society for Therapeutic Radiology and Oncology Patterns of Failure after Induction Chemotherapy and Radiotherapy for Loco-Regionally Advanced Nasopharyngeal Carcinoma: The Queen Mary Hospital Experience
Investigator(s):	Chua DTT
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2000

Project Title:	2001 Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology Control of Regional Metastasis after Induction Chemotherapy and Radiotherapy for Nasopharyngeal Carcinoma
Investigator(s):	Chua DTT
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2001

Project Title:	The Radiological Society of North America 89th Scientific Assembly and Annual Meeting Prognostic Value of Tumor Volume in Early Stage Nasopharyngeal Carcinoma Treated by Radiotherapy
Investigator(s):	Chua DTT
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2003

Project Title:	46th Annual Meeting of the American Society for Therapeutic Radiology and Oncology Prognostic Impact of Hemoglobin Level on Treatment Outcome in Patients with Nasopharyngeal Carcinoma Treated with Sequential Chemoradiotherapy or Radiotherapy Alone
Investigator(s):	Chua DTT
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2004

Researcher : DENG M

List of Research Outputs

DENG M., Cheung A.K.L., Dai W., Yu V.Z.Y. and Lung M.L., In: 110th American Association Cancer Research Annual Meeting, Atlanta, Georgia, USA. March 29- April 3, 2019., Functional and molecular analysis of the somatic mutations in NF-ĸB pathway inhibitor, CYLD, in nasopharyngeal carcinoma.. 2019.

Researcher : Dai W

Project Title:	Establishment of Gene Panel for Predicting Platinum-based Chemoresistance in Cancers
Investigator(s):	Dai W, Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	Seed Fund for Basic Research for New Staff
Start Date:	03/2017
Completion Date:	08/2018

Project Title:	Genomic and Functional Study by Targeting MST1R and Its Related Chromosome 3p21.3 Region Associated with Genetic Susceptibility in Nasopharyngeal Carcinoma
Investigator(s):	Dai W, Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2019

List of Research Outputs

CHOI S.S...A., Dai W., Yu V.Z.Y., Ko J.M.Y. and Lung M.L., Functional Characterization of ZNF750 in esophageal squamous cell carcinoma., 110th American Association Cancer Research Annual Meeting, Atlanta, Georgia, USA. March 29- April 3, 2019.. 2019.

Chen H.L., Ji M., Zong J.F., Ko J.M.Y., Dai W. and Lung M.L., Conventional and novel diagnostic biomarkers and approaches for detection of nasopharyngeal carcinoma., Nasopharyngeal Carcinoma: Etiology to Clinical Practice. Elsevier AP, 2019, 129-153.

DENG M., Cheung A.K.L., Dai W., Yu V.Z.Y. and Lung M.L., In: 110th American Association Cancer Research Annual Meeting, Atlanta, Georgia, USA. March 29- April 3, 2019., Functional and molecular analysis of the somatic mutations in NF-ĸB pathway inhibitor, CYLD, in nasopharyngeal carcinoma.. 2019.

Dai W., Ko J.M.Y., Ng H.Y. and Lung M.L., Genomic Profiles to Identify the Key Events in Metastasis for Esophageal Squamous Cell Carcinoma, Gordon Research Conference on Translational Cancer Genomics. June 30-July 5, Hong Kong. 2019.

Ko J.M.Y., Vardhanabhuti V., Ng W.T., Lam K.O., Ngan K.C.R., Kwong D.L.W., Lee V.H.F., Lui Y.H., Yau C.C., Kwan C.K., Li W.S., Yau S., Guo C., Choi S.S.A., Lei C.L., Chan K.C., Lam C.S.C., Chang C.K.C., Dai W., Khong P.L. and Lung M.L., In: Gordon Research Conference on Translational Cancer Genomics. Hong Kong. June 30-July 5, 2019., Complementary role of circulating tumor cell and cfDNA improves detection of minimal residual disease in metastatic nasopharyngeal carcinoma.. 2019.

LEONG M.L., Cheung A.K.L., Dai W., Tsao G.S.W. and Lung M.L., EBV-associated histone modifications in the regulation of DNA damage repair members resulting in cisplatin resistance in nasopharyngeal carcinoma, The 77th Annual Meeting of the Japanese Cancer Association. Osaka, Japan, Sept 27-29, 2018.

Lam C.S.C., Dai W., Ko J.M.Y. and Lung M.L., Evaluation of Two Next- Generation Sequencing Platforms for Genomic Analysis in Circulating Tumor Cells., 110th American Association Cancer Research Annual Meeting, Atlanta, Georgia, USA.. 2019.

Leong M.L., Cheung A.K.L., Dai W., Tsao G.S.W., Dawson C.W. and Lung M.L., EBV modulates histone H3K4me3 and H3K27me3 bivalent switch to suppress DNA damage repair pathway members in epithelial cells., PNAS 2019. 2019.

Leong M.L., Cheung A.K.L., Dai W., Tsao G.S.W. and Lung M.L., EBV-associated bivalent histone modifications regulate DNA damage repair and cisplatin resistance in epithelial malignancy., 110th American Association Cancer Research Annual Meeting, Atlanta, Georgia, USA. March 29- April 3, 2019.. 2019.

Li B., Hong P., Zheng C.C., Dai W., Chen W.Y., Yang Q.S., Han L., Tsao G.S.W., Chan K.T., Lee N.P.Y., Law S.K., Xu L.Y., Li E.M., Chan K.W., Qin Y.R., Guan X., Lung M.L., He Q.Y., Xu W.W. and Cheung A., Identification of miR-29c and its Target FBXO31 as a Key Regulatory Mechanism in Esophageal Cancer Chemoresistance: Functional Validation and Clinical Significance., Theranostics 2019. 2019, 9(6):1599-1613.

Li J., Ko J.M.Y., Dai W., Ning L., Ng H.Y., Yu V.Z.Y. and Lung M.L., Functional Characterization of Pol in esophageal squamous cell carcinoma., 110th American Association Cancer Research Annual Meeting, Atlanta, Georgia, USA. March 29- April 3, 2019.. 2019.

Lin W., Yip Y.L., Jia L.J., Deng W., Zheng H., Dai W., Ko J.M.Y., Lo K.W., Chung G.T.Y., Yip K.Y., Lee S.D., Kwan J.S.H., Zhang J., Liu T.F., Chan Y.W., Kwong D.L.W., Lee V.H.F., Nicholls J.M., Busson P., Liu X.F., Chiang A.K.S., Hui K.F., Kwok H., Cheung S.T., Cheung Y.C., Chan C.K., Li B., Cheung A., Hau P.M., Zhou Y., Tsang C.M., Middeldorp J., Chen H., Lung M.L. and Tsao G.S.W., Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma, Nature Communications. 2018, 7; 9(1): 4663.

Lung M.L., Dai W. and Ko J.M.Y., Nasopharyngeal carcinoma: genetics and genomics. Nasopharyngeal Carcinoma., Etiology to Clinical Practice. Elsevier AP, 2019, 17-44.

Researcher : FANG S

List of Research Outputs

FANG S., Dai Y., Mei Y., Yang M., Hu L., Yang H., Guan X. and Li J., Clinical significance and biological role of cancer-derived Type I collagen in lung and esophageal cancers, Thorac Cancer. 2019, 10(2): 277-288.

Fang S., Liu M., Li L., ZHANG F., Li Y., CUI Y., Zhu Y.H., Yuan Y.F. and Guan X., Lymphoid enhancer-binding factor-1 promotes stemness and poor differentiation of hepatocellular carcinoma by directly activating the NOTCH pathway, Oncogene. 2019, 38(21): 4061-4074.

Researcher : Fang S

List of Research Outputs

Researcher : Guan X

Project Title:	49th Annual Meeting of the American Society of Human Genetics The Association of Chromosome 8p Deletion and Tumor Metastasis in Human Hepatocellular Carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/1999

Project Title:	51st Annual Meeting of the American Society of Human Genetics Loss of Tyrosine Aminotransferase may Contribute to the Development of Hepatocellular Carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2001

Project Title:	Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	03/2009

Project Title:	Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	03/2009

Project Title:	Outstanding Researcher Award 2011-12
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	01/2013

Project Title:	Cancer
Investigator(s):	Guan X, Chan CLW, Tsao GSW
Department:	Clinical Oncology
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	11/2013

Project Title:	Investigation of effects and molecular mechanisms of FGFR2-positive cancer-associate fibroblasts on tumor microenvironment in esophageal squamous cell carcinoma
Investigator(s):	Guan X, Chen Z, Ma SKY
Department:	Clinical Oncology
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	04/2015

Project Title:	Exploring the Mechanism for Cancer Associated Fibroblasts Recruitment and the Potential Therapeutic Value in Esophageal Squamous Cell Carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	Establishing an intracellular targeting antibody platform for cancer treatment
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2015

Project Title:	Characterization of the suppressive effects of ANG3 on cancer growth, metastasis and angiogenesis in hepatocellular carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2016

Project Title:	Outstanding Research Student Supervisor Award 2015-16
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	11/2016

Project Title:	Characterization of the effect of Maelstrom in cancer stemness in hepatocellular carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2017

Project Title:	Investigating the effect of Rho GTPases regulator ARHGAP15 on gastric cancer metastasis
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2018

Project Title:	Characterization of the role of DPPA3 in stemness regulation in hepatocellular carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Seed Fund for Basic Research for Resubmission of GRF/ECS Proposals
Start Date:	07/2018

Project Title:	Identification and characterization of genes and microenvironment factors driving the metastasis of upper gastrointestinal tract cancers
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	04/2019

List of Research Outputs

CHAN L.H., Zhou L., Ng K.Y., Wong T.L., Lee T.K., Sharma R., LOONG H.C., Ching Y.P., Yuan Y.F., Xie D., Lo C.M., Man K., Artegiani B., Clevers H., Yan H.H.N., Leung S.Y., Richard S., Guan X., Huen M.S.Y. and Ma S.K.Y., Protein arginine methyltransferase PRMT6 regulates RAS/RAF binding and MEK/ERK-mediated cancer stemness activities in hepatocellular carcinoma through CRAF methylation, Cell Reports. 2018.

CHE N., Ng K.Y., Tong M., Lui Kau W.F., Huen M.S.Y., Guan X. and Ma S.K.Y., Functional and Mechanistic Characterisation of PRMT6-regulated Autophagy in Hepatocellular Carcinoma, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

CHE N., Ng K.Y., Tong M., Lui Kau W.F., Guan X., Huen M.S.Y. and Ma S.K.Y., Functional and mechanistic characterization of PRMT6-regulated autophagy in hepatocellular carcinoma, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

CHE N., Ng K.Y., Tong M., Lui Kau W.F., Guan X., Huen M.S.Y. and Ma S.K.Y., Protein arginine methylation by PRMT6 regulates autophagy in hostile microenvironment of hepatocellular carcinoma tumours, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

CHE N., Ng K.Y., Tong M., Lui Kau W.F., Guan X., Huen M.S.Y. and Ma S.K.Y., Protein arginine methylation by PRMT6 regulates autophagy in hostile microenvironment of hepatocellular carcinoma tumours, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

Chen X., Zhang J., Luo J.H., Wu S., Yuan G., Ma N.F., Feng Y., Cai M., Chen R., Lu J., Jiang L., Chen J.W., Jin X.H., Liu H., Chen W., Guan X., Kang T., Zhou F.J. and Xie D., CSTF2-induced shortening of the RAC1 3'UTR promotes the pathogenesis of urothelial carcinoma of the bladder, Cancer Research. 2018, 78(20): 5848-5862.

FANG S., Dai Y., Mei Y., Yang M., Hu L., Yang H., Guan X. and Li J., Clinical significance and biological role of cancer-derived Type I collagen in lung and esophageal cancers, Thorac Cancer. 2019, 10(2): 277-288.

Fang S., Liu M., Li L., ZHANG F., Li Y., CUI Y., Zhu Y.H., Yuan Y.F. and Guan X., Lymphoid enhancer-binding factor-1 promotes stemness and poor differentiation of hepatocellular carcinoma by directly activating the NOTCH pathway, Oncogene. 2019, 38(21): 4061-4074.

JIANG C., CHEN J., Xie S., Zhang L., Xiang Y., Lung M.L., Kam N.W., Kwong D.L.W., Cao S. and Guan X., Evaluation of circulating EBV microRNA BART2-5p in facilitating early detection and screening of nasopharyngeal carcinoma, International Journal of Cancer. 2018.

Kwong D.L.W., Guan X. and Kam Y.N., The effect of tumor derived HMBG1 on intra-tumoral B cells in esophageal squamous cell carcinoma, ESMO Immuno-Oncology Congress 2018, 13-16 December 2018, Geneva, Switzerland. Oxford University Press, 2018.

Li B., Hong P., Zheng C.C., Dai W., Chen W.Y., Yang Q.S., Han L., Tsao G.S.W., Chan K.T., Lee N.P.Y., Law S.K., Xu L.Y., Li E.M., Chan K.W., Qin Y.R., Guan X., Lung M.L., He Q.Y., Xu W.W. and Cheung A., Identification of miR-29c and its Target FBXO31 as a Key Regulatory Mechanism in Esophageal Cancer Chemoresistance: Functional Validation and Clinical Significance., Theranostics 2019. 2019, 9(6):1599-1613.

Li B., Hong P., Zheng C.-.C., Dai W., Chen W.-.Y., Yang Q.-.S., HAN L., Tsao G.S.W., Chan K.T., Lee N.P.Y., Law S.Y.K., Xu L.Y., Li E.M., Chan K.W., Qin Y.R., Guan X., Lung M.L., He Q.-.Y., Xu W. and Cheung A., Identification of miR-29c and its Target FBXO31 as a Key Regulatory Mechanism in Esophageal Cancer Chemoresistance: Functional Validation and Clinical Significance, Theranostics. 2019, 9: 1599-1613.

Li C.X., Chen L.L., Li X.C., Ng K.T.P., Yang X., Lo C.M., Guan X. and Man K., ApoA-1 accelerates regeneration of small-for-size fatty liver graft after transplantation, Life Sciences. 2018, 215: 128-135.

Li L., Li J., Yang H., Zhang X., Liu L., Li Y., Zeng T., Zhu Y.H., Li X.D., Li Y., Xie D., Fu L. and Guan X., Expansion of cancer stem cell pool initiates lung cancer recurrence before angiogenesis, Proc Natl Acad Sci USA . 2018, 115(38): E8948-E8957.

Li L., Liu Y.D., Zhan Y.T., Zhu Y.H., Li Y., Xie D. and Guan X., High levels of CCL2 or CCL4 in the tumor microenvironment predict unfavorable survival in lung adenocarcinoma, Thorac Cancer. 2018, 9(7): 775-784.

Li L., Yang H., Li Y., Li X.D., Zeng T., Lin S., Zhu Y. and Guan X., Hypoxia restrains the expression of complement component 9 in tumor-associated macrophages promoting non-small cell lung cancer progression, Cell Death Discovery. 2018, 4: 63.

Li M., Guan X. and Qin Y., Suppressor gene GRHL1 is associated with prognosis in patients with oesophageal squamous cell carcinoma, Oncology Letters. 2019, 17(5): 4313-4320.

Li Y., He L.R., Gao Y., Zhou N.N., Liu Y., Zhou X.K., Liu J.F., Guan X., Ma N.F. and Xie D., CHD1L contributes to cisplatin resistance by upregulating the ABCB1-NF-κB axis in human non-small-cell lung cancer, Cell Death Dis. 2019, 10(2): 99.

Li Y., Lin S., Li L., Tang Z., Hu Y., Ban X., Zeng T., Zhou Y., Zhu Y.H., Gao S., Deng W., Zhang X., Xie D., Yuan Y., Huang P., Li J., Cai Z. and Guan X., PDSS2 deficiency induces hepatocarcinogenesis by decreasing mitochondrial respiration activity and reprogramming glucose metabolism, Cancer Research. 2018, 78(16): 4471-4481.

Mao X., Tey S.K., Ko F.C.F., Kwong M.L., Goa Y., Ng I.O.L., Cheung S.T., Guan X. and Yam J.W.P., C-terminal truncated HBx protein activates caveolin-1/LRP6/β-catenin/FRMD5 axis in promoting hepatocarcinogenesis, Cancer Letters. 2019, 444: 60-69.

Pang P.S., LIU T., Lin W., Tsang C.M., Yip Y.L., Zhou Y.L., Guan X., Chan R.C.K., Tsao G.S.W. and Deng W., Defining early events of Epstein–Barr virus (EBV) infection in immortalized nasopharyngeal epithelial cells using cell-free EBV infection, Journal of General Virology. 2019, 100: 999-1012.

SIN T.K., Li Y., Liu M., Ma S.K.Y. and Guan X., TROP-2 exhibits tumor suppressive functions in cervical cancer by dual inhibition of IGF-1R and ALK signaling, Gynecol Oncol. 2019, 152(1): 185-193.

Sin S.T., Li Y., Liu M., Yuan Y.F., Ma S.K.Y. and Guan X., Down-regulation of TROP-2 predicts poor prognosis of hepatocellular carcinoma patients, Hepatology Communications. 2018.

Tang H., Jiang L., Zhu C., Liu W.M.R., Wu Y., Yan Q., Liu M., Jia Y., Chen J., Qin Y., Lee V.H.F., Luo S., Wang Q. and Guan X., Loss of cell adhesion molecule L1 like promotes tumor growth and metastasis in esophageal squamous cell carcinoma, Oncogene. 2019.

Wang F.W., Cao C.H., Han K., Zhao Y.X., Cai M.Y., Xiang Z.C., Zhang J.X., Chen J.W., Zhong L.P., Huang Y., Zhou S.F., Jin X.H., Guan X., Xu R.H. and Xie D., APC-activated long non-coding RNA inhibits colorectal carcinoma pathogenesis through reducing exosome production, Journal of Clinical Investigation. 2019, 129(2): 727-743.

Wang L., Li M., Zhan Y., Ban X., Zeng T., Zhu Y., Yun J., Guan X. and Li Y., Down-regulation of POTEG predicts poor prognosis in esophageal squamous cell carcinoma patients, Molecular Carcinogenesis. 2018, 57: 886-895.

Xiong J.X., Wang Y.S., Sheng J., Xiang D., Huang T.X., Tan B.B., Zeng C.M., Li H.H., Yang J., Meltzer S.J., Mori Y., Qin Y.R., Guan X. and Fu L., Epigenetic alterations of a novel antioxidant gene SLC22A3 predispose susceptible individuals to increased risk of esophageal cancer., Int J Biol Sci. 2018, 14(12): 1658-1668.

YANG X., LIANG R., Liu C.X., Liu A.J., Cheung M.P.L., Liu X.L., Man O.Y., Guan X., Lung H.L. and Cheung M.C.H., SOX9 is a dose-dependent metastatic fate determinant in melanoma, Journal of Experimental & Clinical Cancer Research. 2019, 38.

Zheng Y.L., Li L., Jia Y., Zhang B.Z., Li J.C., Zhu Y.H., Li M.Q., HE J., Zeng T.T., Ban X.J., Yuan Y.F., Li Y. and Guan X., LINC01554-mediated glucose metabolism reprogramming suppresses tumorigenicity in hepatocellular carcinoma via downregulating PKM2 Expression and Inhibiting Akt/mTOR Signaling Pathway, Theranostics. 2019, 9(3): 796-810.

Researcher : Guan X.

Project Title:	49th Annual Meeting of the American Society of Human Genetics The Association of Chromosome 8p Deletion and Tumor Metastasis in Human Hepatocellular Carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/1999

Project Title:	51st Annual Meeting of the American Society of Human Genetics Loss of Tyrosine Aminotransferase may Contribute to the Development of Hepatocellular Carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2001

Project Title:	Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	03/2009

Project Title:	Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	03/2009

Project Title:	Outstanding Researcher Award 2011-12
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	01/2013

Project Title:	Cancer
Investigator(s):	Guan X, Chan CLW, Tsao GSW
Department:	Clinical Oncology
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	11/2013

Project Title:	Investigation of effects and molecular mechanisms of FGFR2-positive cancer-associate fibroblasts on tumor microenvironment in esophageal squamous cell carcinoma
Investigator(s):	Guan X, Chen Z, Ma SKY
Department:	Clinical Oncology
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	04/2015

Project Title:	Exploring the Mechanism for Cancer Associated Fibroblasts Recruitment and the Potential Therapeutic Value in Esophageal Squamous Cell Carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	Establishing an intracellular targeting antibody platform for cancer treatment
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2015

Project Title:	Characterization of the suppressive effects of ANG3 on cancer growth, metastasis and angiogenesis in hepatocellular carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2016

Project Title:	Outstanding Research Student Supervisor Award 2015-16
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	11/2016

Project Title:	Characterization of the effect of Maelstrom in cancer stemness in hepatocellular carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2017

Project Title:	Investigating the effect of Rho GTPases regulator ARHGAP15 on gastric cancer metastasis
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2018

Project Title:	Characterization of the role of DPPA3 in stemness regulation in hepatocellular carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Seed Fund for Basic Research for Resubmission of GRF/ECS Proposals
Start Date:	07/2018

Project Title:	Identification and characterization of genes and microenvironment factors driving the metastasis of upper gastrointestinal tract cancers
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	04/2019

List of Research Outputs

Researcher : Guan XY

Project Title:	49th Annual Meeting of the American Society of Human Genetics The Association of Chromosome 8p Deletion and Tumor Metastasis in Human Hepatocellular Carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/1999

Project Title:	51st Annual Meeting of the American Society of Human Genetics Loss of Tyrosine Aminotransferase may Contribute to the Development of Hepatocellular Carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2001

Project Title:	Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	03/2009

Project Title:	Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	03/2009

Project Title:	Outstanding Researcher Award 2011-12
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	01/2013

Project Title:	Cancer
Investigator(s):	Guan X, Chan CLW, Tsao GSW
Department:	Clinical Oncology
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	11/2013

Project Title:	Investigation of effects and molecular mechanisms of FGFR2-positive cancer-associate fibroblasts on tumor microenvironment in esophageal squamous cell carcinoma
Investigator(s):	Guan X, Chen Z, Ma SKY
Department:	Clinical Oncology
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	04/2015

Project Title:	Exploring the Mechanism for Cancer Associated Fibroblasts Recruitment and the Potential Therapeutic Value in Esophageal Squamous Cell Carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	Establishing an intracellular targeting antibody platform for cancer treatment
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2015

Project Title:	Characterization of the suppressive effects of ANG3 on cancer growth, metastasis and angiogenesis in hepatocellular carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2016

Project Title:	Outstanding Research Student Supervisor Award 2015-16
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	11/2016

Project Title:	Characterization of the effect of Maelstrom in cancer stemness in hepatocellular carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2017

Project Title:	Investigating the effect of Rho GTPases regulator ARHGAP15 on gastric cancer metastasis
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2018

Project Title:	Characterization of the role of DPPA3 in stemness regulation in hepatocellular carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Seed Fund for Basic Research for Resubmission of GRF/ECS Proposals
Start Date:	07/2018

Project Title:	Identification and characterization of genes and microenvironment factors driving the metastasis of upper gastrointestinal tract cancers
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	04/2019

List of Research Outputs

Researcher : Guo C

List of Research Outputs

Ko J.M.Y., Vardhanabhuti V., Ng W.T., Lam K.O., Ngan K.C.R., Kwong D.L.W., Lee V.H.F., Lui Y.H., Yau C.C., Kwan C.K., Li W.S., Yau S., Guo C., Choi S.S.A., Lei C.L., Chan K.C., Lam C.S.C., Chang C.K.C., Dai W., Khong P.L. and Lung M.L., In: Gordon Research Conference on Translational Cancer Genomics. Hong Kong. June 30-July 5, 2019., Complementary role of circulating tumor cell and cfDNA improves detection of minimal residual disease in metastatic nasopharyngeal carcinoma.. 2019.

Researcher : HE J

List of Research Outputs

Zheng Y.L., Li L., Jia Y., Zhang B.Z., Li J.C., Zhu Y.H., Li M.Q., HE J., Zeng T.T., Ban X.J., Yuan Y.F., Li Y. and Guan X., LINC01554-mediated glucose metabolism reprogramming suppresses tumorigenicity in hepatocellular carcinoma via downregulating PKM2 Expression and Inhibiting Akt/mTOR Signaling Pathway, Theranostics. 2019, 9(3): 796-810.

Researcher : Ho PYP

List of Research Outputs

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., O'Sullivan B., Lai V., Tong C.C., Lam K.O., Ng C.Y., Chan S.Y., Ho P.Y.P., Chan W.L.W., Leung D.K., Chan S.K., Tsang K.C., Khong P.L., Luk M.Y. and Lee W.M.A., 5-Year Results of the Prognostic Roles of Serial Post-Intensity-Modulated Radiation Therapy Undetectable Plasma EBV DNA for Non-Metastatic Nasopharyngeal Carcinoma, International Journal of Radiation Oncology*Biology*Physics. 2018, 102: S126-S127.

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., O'Sullivan B., Lam K.O., Lai V., Khong P.L., Chan S.K., Ng C.Y., Tong C.C., Ho P.Y.P., Chan W.L.W., Wong L.S., Leung D.K.C., Chan S.Y., So T.H., Luk M.Y. and Lee W.M.A., The addition of pretreatment plasma Epstein-Barr virus DNA into the 8th edition of nasopharyngeal cancer TNM stage classification, International Journal of Cancer. 2018.

Researcher : JIANG C

List of Research Outputs

JIANG C., CHEN J., Xie S., Zhang L., Xiang Y., Lung M.L., Kam N.W., Kwong D.L.W., Cao S. and Guan X., Evaluation of circulating EBV microRNA BART2-5p in facilitating early detection and screening of nasopharyngeal carcinoma, International Journal of Cancer. 2018.

Researcher : Jia Y

List of Research Outputs

Zheng Y.L., Li L., Jia Y., Zhang B.Z., Li J.C., Zhu Y.H., Li M.Q., HE J., Zeng T.T., Ban X.J., Yuan Y.F., Li Y. and Guan X., LINC01554-mediated glucose metabolism reprogramming suppresses tumorigenicity in hepatocellular carcinoma via downregulating PKM2 Expression and Inhibiting Akt/mTOR Signaling Pathway, Theranostics. 2019, 9(3): 796-810.

Researcher : Jiang L

List of Research Outputs

Tang H., Jiang L., Zhu C., Liu W.M.R., Wu Y., Yan Q., Liu M., Jia Y., Chen J., Qin Y., Lee V.H.F., Luo S., Wang Q. and Guan X., Loss of cell adhesion molecule L1 like promotes tumor growth and metastasis in esophageal squamous cell carcinoma, Oncogene. 2019.

Researcher : Kam NW

Project Title:	AACR Annual Meeting 2019; Nasopharyngeal cancer
Investigator(s):	Kam NW
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2019
Completion Date:	04/2019

List of Research Outputs

JIANG C., CHEN J., Xie S., Zhang L., Xiang Y., Lung M.L., Kam N.W., Kwong D.L.W., Cao S. and Guan X., Evaluation of circulating EBV microRNA BART2-5p in facilitating early detection and screening of nasopharyngeal carcinoma, International Journal of Cancer. 2018.

Researcher : Ko JMY

Project Title:	The clinical relevance of telomere attrition and NPC genetic susceptibility
Investigator(s):	Ko JMY, Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	02/2015

Project Title:	Genomic and functional study of rare deleterious germline mutations in RAD50 associated with familial risk for esophageal carcinoma
Investigator(s):	Ko JMY, Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017
Completion Date:	12/2018

Project Title:	Genomic and functional study of rare deleterious germline mutations in candidate genes associated with familial risk for esophageal carcinoma
Investigator(s):	Ko JMY, Huen MSY, Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2018

List of Research Outputs

CHOI S.S...A., Dai W., Yu V.Z.Y., Ko J.M.Y. and Lung M.L., Functional Characterization of ZNF750 in esophageal squamous cell carcinoma., 110th American Association Cancer Research Annual Meeting, Atlanta, Georgia, USA. March 29- April 3, 2019.. 2019.

Chen H.L., Ji M., Zong J.F., Ko J.M.Y., Dai W. and Lung M.L., Conventional and novel diagnostic biomarkers and approaches for detection of nasopharyngeal carcinoma., Nasopharyngeal Carcinoma: Etiology to Clinical Practice. Elsevier AP, 2019, 129-153.

Dai W., Ko J.M.Y., Ng H.Y. and Lung M.L., Genomic Profiles to Identify the Key Events in Metastasis for Esophageal Squamous Cell Carcinoma, Gordon Research Conference on Translational Cancer Genomics. June 30-July 5, Hong Kong. 2019.

Ko J.M.Y., Vardhanabhuti V., Ng W.T., Lam K.O., Ngan K.C.R., Kwong D.L.W., Lee V.H.F., Lui Y.H., Yau C.C., Kwan C.K., Li W.S., Yau S., Guo C., Choi S.S.A., Lei C.L., Chan K.C., Lam C.S.C., Chang C.K.C., Dai W., Khong P.L. and Lung M.L., In: Gordon Research Conference on Translational Cancer Genomics. Hong Kong. June 30-July 5, 2019., Complementary role of circulating tumor cell and cfDNA improves detection of minimal residual disease in metastatic nasopharyngeal carcinoma.. 2019.

LEI C., Yu V.Z.Y., Ning L., Ko J.M.Y., Wang L.D. and Lung M.L., FANCD2 deletion suppresses tumor growth in esophageal squamous cell carcinoma., 110th American Association Cancer Research Annual Meeting, Atlanta, Georgia, USA. March 29- April 3, 2019.. 2019.

Lam C.S.C., Dai W., Ko J.M.Y. and Lung M.L., Evaluation of Two Next- Generation Sequencing Platforms for Genomic Analysis in Circulating Tumor Cells., 110th American Association Cancer Research Annual Meeting, Atlanta, Georgia, USA.. 2019.

Li J., Ko J.M.Y., Dai W., Ning L., Ng H.Y., Yu V.Z.Y. and Lung M.L., Functional Characterization of Pol in esophageal squamous cell carcinoma., 110th American Association Cancer Research Annual Meeting, Atlanta, Georgia, USA. March 29- April 3, 2019.. 2019.

Lin W., Yip Y.L., Jia L.J., Deng W., Zheng H., Dai W., Ko J.M.Y., Lo K.W., Chung G.T.Y., Yip K.Y., Lee S.D., Kwan J.S.H., Zhang J., Liu T.F., Chan Y.W., Kwong D.L.W., Lee V.H.F., Nicholls J.M., Busson P., Liu X.F., Chiang A.K.S., Hui K.F., Kwok H., Cheung S.T., Cheung Y.C., Chan C.K., Li B., Cheung A., Hau P.M., Zhou Y., Tsang C.M., Middeldorp J., Chen H., Lung M.L. and Tsao G.S.W., Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma, Nature Communications. 2018, 7; 9(1): 4663.

Lung M.L., Dai W. and Ko J.M.Y., Nasopharyngeal carcinoma: genetics and genomics. Nasopharyngeal Carcinoma., Etiology to Clinical Practice. Elsevier AP, 2019, 17-44.

Ning L., Ko J.M.Y. and Lung M.L., Validation of CDKN2B-AS1 in nasopharyngeal carcinoma genetic susceptibility by targeted sequencing, Gordon Research Conference on Translational Cancer Genomics. 2019.

Researcher : Kong FP

List of Research Outputs

Kong F.P., Advances in Radiation Oncology in lung cancer, Wenzhou, Zhejiang China. 2019.

Kong F.P., Clinical Trial Advances in NSCLC, People’s Hospital of Shenzhen, Shenzhen, China. 2019.

Kong F.P., Clinical trial organizations in United States and China; Impact on pediatric cancer care, Chinese national annual meeting of Neuropediatric oncology, Guangzhou, China. 2019.

Kong F.P., Cooperative groups for Clinical Trial in United States, Sun Yat-Sen university Cancer Hospital Annual Meeting on Radiation Oncology advances, Guanzhou, China. 2019.

Kong F.P., How could a small potato do a Big Clinical trial? , The First Shenzhen workshop for clinical trial design. 2019.

Kong F.P., Imaging and biomarker guided adaptive radiation therapy in NSCLC, the 8th Landorff Symposium, Freigburg, Germany. 2019.

Kong F.P., Non-surgical management for unresectable stage III non-small cell lung cancer, The First Shenzhen workshop for clinical trial design. 2019.

Kong F.P., RT and Clinical Trial Advances in NSCLC, People’s Hospital of Shenzhen, Shenzhen, China. 2019.

Kong F.P., Radiation immune modulation: Good and Bad? Advances in immunotherapy , Anticancer Association, Shenzhen, China. 2019.

Kong F.P., Radiation immunomodulation in NSCLC, Annual Meeting of MultiD Thoracic Oncology. 2019.

Kong F.P., SBRT in Non-small cell lung cancer, history and long-term outcome, Linyi Precision Oncology Workshop, Lin Yi, Shandong, China. 2019.

Li L., Ma L., Shang D., Liu Z., Yu Q., Wang S., Teng X., Zhang Q., Hu X., Zhao W., Jin J., Kong F.P., Yu J. and Yuan S., Pretreatment PET/CT imaging of angiogenesis based on (18)F-RGD tracer uptake may predict antiangiogenic response , Eur J Nucl Med Mol Imaging. 2019.

So T.H., Chan S.K., Lee V.H.F., Chen B.Z., Kong F.P. and Lao L., Chinese Medicine in Cancer Treatment -How is it Practiced in the East and the West?, Clinical Oncology . 2019, 31: 578–588.

Researcher : Kwong DLW

Project Title:	Knowledge and Technology Transfer through Advanced Training in Clinical Immunotherapy for Nasopharyngeal Carcinoma and other Virus Associated Malignancies
Investigator(s):	Kwong DLW, Nicholls JM
Department:	Clinical Oncology
Source(s) of Funding:	Zeshan (HK) Foundation
Start Date:	01/2016

Project Title:	Peripheral immunological response to treatment with checkpoint inhibitor in recurrent/metastatic nasopharyngeal carcinoma and correlation with clinical response and adverse effects
Investigator(s):	Kwong DLW, Lee VHF, Lam KO, Guan X, Kam NW
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	09/2018

List of Research Outputs

CHOPRA H., Hung M.K., Kwong D.L.W., Zhang C. and Pow E.H.N., Insights into endothelial progenitor cells: origin, classification, potentials and prospects. , Stem Cells International. 2018, 9847015.

CHOPRA H., Han Y., PAN Y., Kwong D.L.W., Zhang C. and Pow E.H.N., PDLCs and EPCs synergistically enhance osseointegration in irradiated rabbit bone, J Dent Res. 2019, 98.

Chan T.F., Hui K.F., Yang W., Shen J.J., Lam K.P., Kwok H., Sham P.C., Tsao G.S.W., Kwong D.L.W., Lung M.L. and Chiang A.K.S., Genome-wide analysis identifies high-risk Epstein-Barr virus associated with nasopharyngeal carcinoma., HKU Research Postgraduate Seminar, December 5-7, 2018.. 2018.

Hui K.F., CHAN T.F., Yang W., Shen J.J., Lam K.P., Kwok H.I.N., Sham P.C., Tsao G.S.W., Kwong D.L.W., Lung M.L. and Chiang A.K.S., High risk Epstein‐Barr virus variants characterized by distinct polymorphisms in the EBER locus are strongly associated with nasopharyngeal carcinoma, International Journal of Cancer. 2019, 144: 3031-3042.

JIANG C., CHEN J., Xie S., Zhang L., Xiang Y., Lung M.L., Kam N.W., Kwong D.L.W., Cao S. and Guan X., Evaluation of circulating EBV microRNA BART2-5p in facilitating early detection and screening of nasopharyngeal carcinoma, International Journal of Cancer. 2018.

Ko J.M.Y., Vardhanabhuti V., Ng W.T., Lam K.O., Ngan K.C.R., Kwong D.L.W., Lee V.H.F., Lui Y.H., Yau C.C., Kwan C.K., Li W.S., Yau S., Guo C., Choi S.S.A., Lei C.L., Chan K.C., Lam C.S.C., Chang C.K.C., Dai W., Khong P.L. and Lung M.L., In: Gordon Research Conference on Translational Cancer Genomics. Hong Kong. June 30-July 5, 2019., Complementary role of circulating tumor cell and cfDNA improves detection of minimal residual disease in metastatic nasopharyngeal carcinoma.. 2019.

Kwong D.L.W., Advances in oncology practice I – Immuno-oncology, 2nd Hong Kong International Oncology Forum. 2018.

Kwong D.L.W., Camrelizumab for nasopharyngeal carcinoma: a new hope?, The Lancet Oncology. 2018, 19: 1266-1267.

Kwong D.L.W., Clinical update on BRAFm adjuvant melanoma with case sharing, Targeting BRAFm Cancers: A shifting treatment paradigm around mutation status. 2018.

Kwong D.L.W., Emerging scientific rationale of IO in combination with radiotherapy for locally advanced SCCHN and NPC, Taiwan Oncology Society. 2019.

Kwong D.L.W., Management of immune-related adverse event in other tumours, Immuno-Oncology Hong Kong 2018 Preceptorship Programme (IOP Programme). 2018.

Kwong D.L.W., Radiotherapy and chemotherapy for head and neck cancers, The 25th certificate course in ENT diseases for nurses,Tung Wah Hospital. 2019.

Kwong D.L.W., T cell treatment of nasopharyngeal carcinoma, Scientific Meeting of The Hong Kong Head & Neck Society. 2018.

Kwong D.L.W., Guan X. and Kam Y.N., The effect of tumor derived HMBG1 on intra-tumoral B cells in esophageal squamous cell carcinoma, ESMO Immuno-Oncology Congress 2018, 13-16 December 2018, Geneva, Switzerland. Oxford University Press, 2018.

Lam K.O., Chan W.L.W., So T.H., Lee V.H.F. and Kwong D.L.W., Third-line Systemic Treatment In Advanced/metastatic Gastric Cancer: A Comprehensive Review., Ther Adv Med Oncol. 2019.

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., O'Sullivan B., Lai V., Tong C.C., Lam K.O., Ng C.Y., Chan S.Y., Ho P.Y.P., Chan W.L.W., Leung D.K., Chan S.K., Tsang K.C., Khong P.L., Luk M.Y. and Lee W.M.A., 5-Year Results of the Prognostic Roles of Serial Post-Intensity-Modulated Radiation Therapy Undetectable Plasma EBV DNA for Non-Metastatic Nasopharyngeal Carcinoma, International Journal of Radiation Oncology*Biology*Physics. 2018, 102: S126-S127.

Lee V.H.F., Kwong D.L.W. and Pu K.S., Central Nervous System Neoplasms in Hong Kong: An inscription of Local Studies, Current Cancer Therapy Reviews. 2019, 15.

Lee V.H.F. and Kwong D.L.W., Systemic Treatment of Chest Tumors: Highlighting Some Differences Between Eastern and Western Countries, Current Cancer Therapy Reviews. 2018, 14: 120-136.

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., O'Sullivan B., Lam K.O., Lai V., Khong P.L., Chan S.K., Ng C.Y., Tong C.C., Ho P.Y.P., Chan W.L.W., Wong L.S., Leung D.K.C., Chan S.Y., So T.H., Luk M.Y. and Lee W.M.A., The addition of pretreatment plasma Epstein-Barr virus DNA into the 8th edition of nasopharyngeal cancer TNM stage classification, International Journal of Cancer. 2018.

Lin W., Yip Y.L., Jia L.J., Deng W., Zheng H., Dai W., Ko J.M.Y., Lo K.W., Chung G.T.Y., Yip K.Y., Lee S.D., Kwan J.S.H., Zhang J., Liu T.F., Chan Y.W., Kwong D.L.W., Lee V.H.F., Nicholls J.M., Busson P., Liu X.F., Chiang A.K.S., Hui K.F., Kwok H., Cheung S.T., Cheung Y.C., Chan C.K., Li B., Cheung A., Hau P.M., Zhou Y., Tsang C.M., Middeldorp J., Chen H., Lung M.L. and Tsao G.S.W., Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma, Nature Communications. 2018, 7; 9(1): 4663.

Mai Z., Lin J., Ngan K.C.R., Kwong D.L.W., Ng W.T., Ng A.W.Y., Yuen K.T., Ip D.K.M., Chan Y.H., Lee W.M.A., Ho D.S.Y., Lung M.L. and Lam T.H., Milk consumption across life periods in relation to lower risk of nasopharyngeal carcinoma: A multicentre case-control study, Frontiers in Oncology. 2019, 9: 253.

Qiao W., Lan X.M., Ma H.X., Chan J.Y.K., Lui V.W.Y., Yeung K.W.K., Kwong D.L.W., Hu Z., Tsoi K.H., Matinlinna J.P. and Su Y., Effects of Salivary Mg on Head and Neck Carcinoma via TRPM7, Journal of Dental Research. 2019, 98: 304-312.

Wong W.I.N.G. .H.A.N.G., Leung H.I.N.G. .T.O.N.G. and Kwong D.L.W., A statistics-based model for prediction of achievability of the planning criteria for IMRT planning, Medical Dosimetry. 2018.

Wong Y.H.I., Lam K.O., Chan W.L.W., Wong L.Y.C., So T.H., Chan K.K.D., Choi C.W., Law T.T., Chiu W.H.K., Chan S.Y., Kwong D.L.W. and Law S.Y.K., Real World Scenario: CROSS regimen as preoperative therapy for esophageal squamous cell carcinoma (Abstract), SSAT Plenary Session: Esophagus and Gastric II, Digestive Disease Week (DDW 2019), San Diego, USA, 18-21 May. 2019.

Yan H.H.N., Siu H.C., Law S.Y.K., Ho R.S.L., Yue S.K.S., Tsui W.Y., Chan D., Chan A.S., Ma S.K.Y., Lam K.O., Bartfeld S., Man H.Y., Lee C.H., Chan A.S.Y., Wong W.H.J., Cheng S.W.P., Chan K.W., Zhang J., Shi J., Fan X., Kwong D.L.W., Mak T.W., Yuen S.T., Clevers H. and Leung S.Y., A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening, Cell Stem Cell. 2018.

Yan H.H.N., Chan D., Siu H.C., Law S.Y.K., Ho R.S.L., Tsui W.Y., Yue S.K.S., Chan A.S., Lee C.H., Chan A.S.Y., Chan K.W., Leung H.C., Hui H.S., Lam K.O., Kwong D.L.W., Mak T.W., Clevers H. and Leung S.Y., Establishment of a large-scale drug sensitivity screening platform on gastric cancer organoid cultures with potential to guide treatment. , American Association for Cancer Research (AACR) and Korean Cancer Association (KCA) Joint Conference on Precision Medicine in Solid Tumors. 2018.

Researcher : LEI C

List of Research Outputs

LEI C., Yu V.Z.Y., Ning L., Ko J.M.Y., Wang L.D. and Lung M.L., FANCD2 deletion suppresses tumor growth in esophageal squamous cell carcinoma., 110th American Association Cancer Research Annual Meeting, Atlanta, Georgia, USA. March 29- April 3, 2019.. 2019.

Researcher : LEONG ML

List of Research Outputs

LEONG M.L., Cheung A.K.L., Dai W., Tsao G.S.W. and Lung M.L., EBV-associated histone modifications in the regulation of DNA damage repair members resulting in cisplatin resistance in nasopharyngeal carcinoma, The 77th Annual Meeting of the Japanese Cancer Association. Osaka, Japan, Sept 27-29, 2018.

Leong M.L., Cheung A.K.L., Dai W., Tsao G.S.W., Dawson C.W. and Lung M.L., EBV modulates histone H3K4me3 and H3K27me3 bivalent switch to suppress DNA damage repair pathway members in epithelial cells., PNAS 2019. 2019.

Leong M.L., Cheung A.K.L., Dai W., Tsao G.S.W. and Lung M.L., EBV-associated bivalent histone modifications regulate DNA damage repair and cisplatin resistance in epithelial malignancy., 110th American Association Cancer Research Annual Meeting, Atlanta, Georgia, USA. March 29- April 3, 2019.. 2019.

Researcher : Lam CSC

List of Research Outputs

Ko J.M.Y., Vardhanabhuti V., Ng W.T., Lam K.O., Ngan K.C.R., Kwong D.L.W., Lee V.H.F., Lui Y.H., Yau C.C., Kwan C.K., Li W.S., Yau S., Guo C., Choi S.S.A., Lei C.L., Chan K.C., Lam C.S.C., Chang C.K.C., Dai W., Khong P.L. and Lung M.L., In: Gordon Research Conference on Translational Cancer Genomics. Hong Kong. June 30-July 5, 2019., Complementary role of circulating tumor cell and cfDNA improves detection of minimal residual disease in metastatic nasopharyngeal carcinoma.. 2019.

Lam C.S.C., Dai W., Ko J.M.Y. and Lung M.L., Evaluation of Two Next- Generation Sequencing Platforms for Genomic Analysis in Circulating Tumor Cells., 110th American Association Cancer Research Annual Meeting, Atlanta, Georgia, USA.. 2019.

Lam C.S.C. and Lung M.L., Utilizing Next Generation Sequencing Technologies for Sequencing Circulating Tumor Cells., Research Postgraduate Symposium, Hong Kong. 2018.

Researcher : Lam KO

Project Title:	Optimizing the selection of patients with metastatic colorectal cancer for liver resection – An immuno-clinical scoring system incorporating circulating tumor cell enumeration and clinical factors.
Investigator(s):	Lam KO, Lung ML, Ko JMY, Chan ACY, Lee VHF
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2017

Project Title:	Redefining resectability for colorectal liver metastasis: the role of circulating tumor cells and its molecular characteristics
Investigator(s):	Lam KO, Chan ACY, Dai W, Ko JMY, Lee VHF, Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	Seed Fund for Basic Research for Resubmission of GRF/ECS Proposals
Start Date:	07/2018
Completion Date:	11/2018

Project Title:	A Phase II Single-Arm two-stage study of CFI-400945 in advanced gastric or gastroesophageal junction adenocarcinoma that progressed after prior therapy with platinum and fluoropyrimidine
Investigator(s):	Lam KO, Kwong DLW, Lee VHF, Chan WLW, Lam TC, Chiang CL, So TH
Department:	Clinical Oncology
Source(s) of Funding:	Hong Kong Cancer Fund - General Award
Start Date:	11/2018

List of Research Outputs

Chan W.L.W. and Lam K.O., Management of Advanced Gastric Cancer, The Hong Kong Medical Diary. 2018.

Chiang C.L., Lam K.O., Chan H.C., Chan B.Y., Lee S.F., Yeung S.Y., Lau K.S., Chan S.Y., Choy T.S. and Yuen K.K., Real‐world treatment patterns and outcomes in refractory metastatic colorectal cancer, Asia-Pacific Journal of Clinical Oncology. 2019.

Chiu W.H.K., Lam K.O., An H., Cheung T.C., Lau K.S., Choy T.S. and Lee V.H.F., Long-term outcomes and recurrence pattern of 18F-FDG PET-CT complete metabolic response in the first-line treatment of metastatic colorectal cancer: a lesion-based and patient-based analysis, BMC Cancer. 2018, 18.

Ko J.M.Y., Vardhanabhuti V., Ng W.T., Lam K.O., Ngan K.C.R., Kwong D.L.W., Lee V.H.F., Lui Y.H., Yau C.C., Kwan C.K., Li W.S., Yau S., Guo C., Choi S.S.A., Lei C.L., Chan K.C., Lam C.S.C., Chang C.K.C., Dai W., Khong P.L. and Lung M.L., In: Gordon Research Conference on Translational Cancer Genomics. Hong Kong. June 30-July 5, 2019., Complementary role of circulating tumor cell and cfDNA improves detection of minimal residual disease in metastatic nasopharyngeal carcinoma.. 2019.

Lam K.O., ASCO Updates on Immunotherapy for GI Cancer: What Surgeons Need to Know, Hong Kong Surgical Forum, Hong Kong. 2019.

Lam K.O., Colorectal Cancer in Daily Practice: Challenges and Opportunities for Translational Research, Theme-Based Research Scheme: Translational Studies for Gastrointestinal Tract Cancers for Personalized Medicine Research Symposium, Hong Kong. 2019.

Lam K.O., Tong C.C., Lee V.H.F., Luk M.Y. and Lam C.W., DPYD genotype-guided dose individualisation of fluoropyrimidine therapy: who and how?, The Lancet Oncology. 2019, 20: e66.

Lam K.O., Editorial Board, JBR Journal of Translational Clinical and Experimental Oncology. 2018.

Lam K.O., MDT in Clinical Practice: Hong Kong Perspectives, Sanofi MDT Symposium, Shenzhen, China. 2019.

Lam K.O. and Huang J., Malignant Priapism And Germ Cell Tumour, The Lancet Oncology. 2019.

Lam K.O., Chan W.L.W., So T.H., Lee V.H.F. and Kwong D.L.W., Third-line Systemic Treatment In Advanced/metastatic Gastric Cancer: A Comprehensive Review., Ther Adv Med Oncol. 2019.

Lam T.H., Wong K.H., Chan K.K.L., Chan M.C.M., Chan D.V.K., Cheung A.N.Y., Fan C.Y.M., Ho D., Hui E.P., Lam K.O., Law C.K., Law W.L., Loong H.H.F., Ngan R.K.C., Tsang T.H.F., Wong M.C.S., Yeung R.M.W. and Ying A.C.H., Recommendations on prevention and screening for colorectal cancer in Hong Kong, Hong Kong Medical Journal. 2018, 24(5): 521-6.

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., O'Sullivan B., Lai V., Tong C.C., Lam K.O., Ng C.Y., Chan S.Y., Ho P.Y.P., Chan W.L.W., Leung D.K., Chan S.K., Tsang K.C., Khong P.L., Luk M.Y. and Lee W.M.A., 5-Year Results of the Prognostic Roles of Serial Post-Intensity-Modulated Radiation Therapy Undetectable Plasma EBV DNA for Non-Metastatic Nasopharyngeal Carcinoma, International Journal of Radiation Oncology*Biology*Physics. 2018, 102: S126-S127.

Lee V.H.F., Lam K.O., Chang T.Y.A., Lam T.C., Chiang C.L., So T.H., Choi C.W. and Lee W.M.A., Management of Nasopharyngeal Carcinoma: Is Adjuvant Therapy Needed?, Journal of Oncology Practice. 2018, 14: 594-602.

Lee V.H.F., Lam K.O. and Lee W.M.A., Standard of Care for Nasopharyngeal Carcinoma (2018–2020), Nasopharyngeal Carcinoma. Elsevier, 2019, 205-238.

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., O'Sullivan B., Lam K.O., Lai V., Khong P.L., Chan S.K., Ng C.Y., Tong C.C., Ho P.Y.P., Chan W.L.W., Wong L.S., Leung D.K.C., Chan S.Y., So T.H., Luk M.Y. and Lee W.M.A., The addition of pretreatment plasma Epstein-Barr virus DNA into the 8th edition of nasopharyngeal cancer TNM stage classification, International Journal of Cancer. 2018.

Tong C.C., Lam C.W., Lam K.O., Lee V.H.F. and Luk M.Y., A Novel DPYD Variant Associated With Severe Toxicity of Fluoropyrimidines: Role of Pre-emptive DPYD Genotype Screening, Frontiers in Oncology. 2018, 8.

Wong K.P., Lang H.H.B., Lam K.O., Shek T.W.H. and Yau T.C.C., Poster presentation: PD-L1 expression in patients with anaplastic thyroid carcinoma: prevalence and outcome, The 88th Annual Meeting of the American Thyroid Association (ATA), Washington, U.S.A., 3-7 October 2018. 2018.

Wong Y.H.I., Lam K.O., Chan W.L.W., Wong L.Y.C., So T.H., Chan K.K.D., Choi C.W., Law T.T., Chiu W.H.K., Chan S.Y., Kwong D.L.W. and Law S.Y.K., Real World Scenario: CROSS regimen as preoperative therapy for esophageal squamous cell carcinoma (Abstract), SSAT Plenary Session: Esophagus and Gastric II, Digestive Disease Week (DDW 2019), San Diego, USA, 18-21 May. 2019.

Yan H.H.N., Siu H.C., Law S.Y.K., Ho R.S.L., Yue S.K.S., Tsui W.Y., Chan D., Chan A.S., Ma S.K.Y., Lam K.O., Bartfeld S., Man H.Y., Lee C.H., Chan A.S.Y., Wong W.H.J., Cheng S.W.P., Chan K.W., Zhang J., Shi J., Fan X., Kwong D.L.W., Mak T.W., Yuen S.T., Clevers H. and Leung S.Y., A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening, Cell Stem Cell. 2018.

Yan H.H.N., Chan D., Siu H.C., Law S.Y.K., Ho R.S.L., Tsui W.Y., Yue S.K.S., Chan A.S., Lee C.H., Chan A.S.Y., Chan K.W., Leung H.C., Hui H.S., Lam K.O., Kwong D.L.W., Mak T.W., Clevers H. and Leung S.Y., Establishment of a large-scale drug sensitivity screening platform on gastric cancer organoid cultures with potential to guide treatment. , American Association for Cancer Research (AACR) and Korean Cancer Association (KCA) Joint Conference on Precision Medicine in Solid Tumors. 2018.

Researcher : Lam TC

Project Title:	A prospective cohort study on demoralization, quality of life and suicidal risk in advanced cancer patients
Investigator(s):	Lam TC, Lam WWT, Lee WMA, Kwong DLW, Lee VHF, Lam KO, So TH, Choi CW
Department:	Clinical Oncology
Source(s) of Funding:	Seed Fund for Basic Research for New Staff
Start Date:	02/2017

Project Title:	Improving Access of MRI in Palliative Cancer Patients to Prevent Spinal Complications
Investigator(s):	Lam TC, Kwan KYH
Department:	Clinical Oncology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	04/2018

Project Title:	Atezolizumab in combination with bevacizumab, carboplatin and pemetrexed for EGFR-mutant metastatic non-small cell lung cancer patients after failure of EGFR tyrosine kinase inhibitors: a single arm phase 2 study
Investigator(s):	Lam TC, Li CB, Chiang CL, Lee VHF, So TH
Department:	Clinical Oncology
Source(s) of Funding:	Roche Hong Kong Limited
Start Date:	11/2018

List of Research Outputs

Lam T.C., Territory-wide review of palliative care service for Hong Kong cancer patients 2006-2015: Implications for future service development, The Second International Palliative Care Summit Forum & Art Action. 2018.

Lam T.C., precision neuro-oncology”- early experience of QMH, Neuroscience meeting. 2018.

Lee V.H.F., Lam K.O., Chang T.Y.A., Lam T.C., Chiang C.L., So T.H., Choi C.W. and Lee W.M.A., Management of Nasopharyngeal Carcinoma: Is Adjuvant Therapy Needed?, Journal of Oncology Practice. 2018, 14: 594-602.

Shi D.D., Hertan L.M., Lam T.C., Skamene S., Chi J.H., Groff M., Cho C.H., Ferrone M.L., Harris M. and Balboni T.A., Assessing the utility of the spinal instability neoplastic score (SINS) to predict fracture after conventional radiation therapy (RT) for spinal metastases., Pract Radiat Oncol. Elsevier, 2018, 8: 285.

Woo P.Y.M., Lam T.C., Pu K.S.J., Li L.F., Leung R.C.Y., Ho J.M.K., Zhung J.T.F., Wong B., Chan T.S.K., Loong H.H.F. and Ng H.K., Regression of BRAF mutant adult glioblastoma after primary combined BRAF-MEK inhibitor targeted therapy: a report of two cases, Oncotarget. 2019, 10(38): 3818-3826.

Researcher : Lee AWM

Project Title:	6th Asian Society of Head & Neck Oncology 2019; International Consensus of CTV Delineation/The Strengths and Weaknesses of EBV-DNA as a biomarker for Nasopharyngeal Cancer
Investigator(s):	Lee WMA
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2019
Completion Date:	03/2019

List of Research Outputs

Researcher : Lee CCY

List of Research Outputs

Zhang N., Fielding R., Soong S.I., Chan K.K.K., Lee C.C.Y., Ng A., Sze W.K., Tsang W.H.J., Lee V.H.F. and Lam W.W.T., Illness perceptions as predictors of psychological distress among head and neck cancer survivors: a longitudinal study, Head & Neck. 2018, 40: 2362-2371.

Researcher : Lee VHF

Project Title:	Granulocyte-colony stimulating factor (G-CSF) support to prevent neutropenia and its complications for patients receiving palliative chemotherapy for their stage IV metastatic cancer
Investigator(s):	Lee VHF, Kwong DLW, Lam KO
Department:	Clinical Oncology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2014

Project Title:	ASTRO 56th Annual Meeting; Comparison of Post-treatment Plasma EBV DNA with Nasopharyngeal Biopsy in Patients After Radical (Chemo)Radiotherapy for Non-metastatic Nasopharyngeal Cancer
Investigator(s):	Lee VHF
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2014

Project Title:	Magnetic resonance imaging (MRI) for monitoring treatment response in patients with inoperable hepatocellular carcinoma treated with transarterial chemoembolization (TACE) and/or radiotherapy
Investigator(s):	Lee VHF, Kwong DLW, Wong CS
Department:	Clinical Oncology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2015

Project Title:	FDG and 11C-acetate PET-CT scan to assess tumour response after stereotactic body radiation therapy as bridging therapy for patients with hepatocellular carcinoma awaiting liver transplantation
Investigator(s):	Lee VHF, Wong CLT, Vardhanabhuti V, Lam KO, Leung TW, Khong PL, Chan SC, Lo CM
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016

Project Title:	Role of individual dietary counselling on weight loss and change in quality of life in patients with nasopharyngeal carcinoma treated with intensity-modulated radiation therapy
Investigator(s):	Lee VHF, Kwong DLW, Lam KO, Sze CKH
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016
Completion Date:	06/2019

Project Title:	Efficient Algorithms and Hardware Accelerators for Tensor Decomposition and Their Applications to Multidimensional Data Analysis
Investigator(s):	Lee VHF
Department:	Clinical Oncology
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2016

Project Title:	Territory-wide evaluation of treatment outcomes of non-metastatic nasopharyngeal carcinoma treated with radical intensity-modulated radiation therapy in Hong Kong
Investigator(s):	Lee VHF, Choi CW, Lee WMA
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2018

Project Title:	Outstanding Young Researcher Award 2017-18
Investigator(s):	Lee VHF
Department:	Clinical Oncology
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	12/2018

Project Title:	Tumour Heterogeneity and Clonal Evolution in Nasopharyngeal Carcinoma
Investigator(s):	Lee VHF, Kam NW, Guan X, Lam KO, Kwong DLW
Department:	Clinical Oncology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2019

Project Title:	PD-L1-positive circulating tumour cells (CTC) in predicting treatment response and survival after concurrent chemoradiation for locally advanced nasopharyngeal carcinoma (NPC)
Investigator(s):	Lee VHF, Guan X, Lee WMA, Kwong DLW, Lam KO, Choi CW, Vardhanabhuti V, Lo WIA
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2019

List of Research Outputs

Chiu W.H.K., Lam K.O., An H., Cheung T.C., Lau K.S., Choy T.S. and Lee V.H.F., Long-term outcomes and recurrence pattern of 18F-FDG PET-CT complete metabolic response in the first-line treatment of metastatic colorectal cancer: a lesion-based and patient-based analysis, BMC Cancer. 2018, 18.

Ko J.M.Y., Vardhanabhuti V., Ng W.T., Lam K.O., Ngan K.C.R., Kwong D.L.W., Lee V.H.F., Lui Y.H., Yau C.C., Kwan C.K., Li W.S., Yau S., Guo C., Choi S.S.A., Lei C.L., Chan K.C., Lam C.S.C., Chang C.K.C., Dai W., Khong P.L. and Lung M.L., In: Gordon Research Conference on Translational Cancer Genomics. Hong Kong. June 30-July 5, 2019., Complementary role of circulating tumor cell and cfDNA improves detection of minimal residual disease in metastatic nasopharyngeal carcinoma.. 2019.

Lam K.O., Tong C.C., Lee V.H.F., Luk M.Y. and Lam C.W., DPYD genotype-guided dose individualisation of fluoropyrimidine therapy: who and how?, The Lancet Oncology. 2019, 20: e66.

Lam K.O., Chan W.L.W., So T.H., Lee V.H.F. and Kwong D.L.W., Third-line Systemic Treatment In Advanced/metastatic Gastric Cancer: A Comprehensive Review., Ther Adv Med Oncol. 2019.

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., O'Sullivan B., Lai V., Tong C.C., Lam K.O., Ng C.Y., Chan S.Y., Ho P.Y.P., Chan W.L.W., Leung D.K., Chan S.K., Tsang K.C., Khong P.L., Luk M.Y. and Lee W.M.A., 5-Year Results of the Prognostic Roles of Serial Post-Intensity-Modulated Radiation Therapy Undetectable Plasma EBV DNA for Non-Metastatic Nasopharyngeal Carcinoma, International Journal of Radiation Oncology*Biology*Physics. 2018, 102: S126-S127.

Lee V.H.F., Kwong D.L.W. and Pu K.S., Central Nervous System Neoplasms in Hong Kong: An inscription of Local Studies, Current Cancer Therapy Reviews. 2019, 15.

Lee V.H.F., Lam K.O., Chang T.Y.A., Lam T.C., Chiang C.L., So T.H., Choi C.W. and Lee W.M.A., Management of Nasopharyngeal Carcinoma: Is Adjuvant Therapy Needed?, Journal of Oncology Practice. 2018, 14: 594-602.

Lee V.H.F., Yu E. and Claude K., Palliative Care for Chest Tumors – Hong Kong, France and Canada, Current Cancer Therapy Reviews. 2018, 14: 167-180.

Lee V.H.F., Lam K.O. and Lee W.M.A., Standard of Care for Nasopharyngeal Carcinoma (2018–2020), Nasopharyngeal Carcinoma. Elsevier, 2019, 205-238.

Lee V.H.F. and Kwong D.L.W., Systemic Treatment of Chest Tumors: Highlighting Some Differences Between Eastern and Western Countries, Current Cancer Therapy Reviews. 2018, 14: 120-136.

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., O'Sullivan B., Lam K.O., Lai V., Khong P.L., Chan S.K., Ng C.Y., Tong C.C., Ho P.Y.P., Chan W.L.W., Wong L.S., Leung D.K.C., Chan S.Y., So T.H., Luk M.Y. and Lee W.M.A., The addition of pretreatment plasma Epstein-Barr virus DNA into the 8th edition of nasopharyngeal cancer TNM stage classification, International Journal of Cancer. 2018.

Lin W., Yip Y.L., Jia L.J., Deng W., Zheng H., Dai W., Ko J.M.Y., Lo K.W., Chung G.T.Y., Yip K.Y., Lee S.D., Kwan J.S.H., Zhang J., Liu T.F., Chan Y.W., Kwong D.L.W., Lee V.H.F., Nicholls J.M., Busson P., Liu X.F., Chiang A.K.S., Hui K.F., Kwok H., Cheung S.T., Cheung Y.C., Chan C.K., Li B., Cheung A., Hau P.M., Zhou Y., Tsang C.M., Middeldorp J., Chen H., Lung M.L. and Tsao G.S.W., Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma, Nature Communications. 2018, 7; 9(1): 4663.

So T.H., Chan S.K., Lee V.H.F., Chen B.Z., Kong F.P. and Lao L., Chinese Medicine in Cancer Treatment -How is it Practiced in the East and the West?, Clinical Oncology . 2019, 31: 578–588.

Tang H., Jiang L., Zhu C., Liu W.M.R., Wu Y., Yan Q., Liu M., Jia Y., Chen J., Qin Y., Lee V.H.F., Luo S., Wang Q. and Guan X., Loss of cell adhesion molecule L1 like promotes tumor growth and metastasis in esophageal squamous cell carcinoma, Oncogene. 2019.

Tong C.C., Lam C.W., Lam K.O., Lee V.H.F. and Luk M.Y., A Novel DPYD Variant Associated With Severe Toxicity of Fluoropyrimidines: Role of Pre-emptive DPYD Genotype Screening, Frontiers in Oncology. 2018, 8.

Wong C.L.T., Chiang C.L., Lee A.S., Lee V.H.F., Yeung C.S.Y., Ho C.H.M., Cheung T.T., Ng K.C.K., Chok K.S.H., Chan A.C.Y., Dai W.C., Wong F.C.S., Luk M.Y., Leung T.W. and Lo C.M., Better survival after stereotactic body radiation therapy following transarterial chemoembolization in nonresectable hepatocellular carcinoma: A propensity score matched analysis, Surgical Oncology. 2019, 28: 228-235.

Wong C.L.T., Lee V.H.F., Law A.H., Cui T.Y., Fung J.Y.Y., Sin S.L., Chan A.C.Y., Dai W.C., Chok K.S.H., Cheung T.T., Ng K.C.K., Leung T.W. and Lo C.M., Prospective study of stereotactic body radiation therapy as a bridging therapy for hepatocellular carcinoma patients on waiting list for liver transplantation., International Liver Transplant Society 25th Annual Congress, Toronto, Canada, 15-18 May 2019 . 2019.

Wu Y.L., Lee V.H.F., Liam C.K., Lu S., Park K., Srimuninnimit V., Wang J., Zhou C.C., Appius A., Button P., Hooper G., Palma J.F., Schulze K., Scudder, S., Shames D.S., Yin A.Y. and Zhang G.L., Mok T., Clinical utility of a blood-based EGFR mutation test in patients receiving first-line erlotinib therapy in the ENSURE, FASTACT-2, and ASPIRATION studies, Lung Cancer. 2018, 126: 1-8.

Zhang N., Fielding R., Soong S.I., Chan K.K.K., Lee C.C.Y., Ng A., Sze W.K., Tsang W.H.J., Lee V.H.F. and Lam W.W.T., Illness perceptions as predictors of psychological distress among head and neck cancer survivors: a longitudinal study, Head & Neck. 2018, 40: 2362-2371.

Researcher : Lee WMA

Project Title:	6th Asian Society of Head & Neck Oncology 2019; International Consensus of CTV Delineation/The Strengths and Weaknesses of EBV-DNA as a biomarker for Nasopharyngeal Cancer
Investigator(s):	Lee WMA
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2019
Completion Date:	03/2019

List of Research Outputs

Chan L.S., Man O.Y., Kwok H.H., Chen L., Chan K.C., Lung H.L., Ngan K.C.R., Wong R.N.S., Lo K.W., Lee W.M.A., Tsao G.S.W., Kahn M., Lung M.L. and Mak N.K., The Wnt modulator ICG‑001 mediates the inhibition of nasopharyngeal carcinoma cell migration in vitro via the miR‑150/CD44 axis., Int J Oncol.. 2018, 54(3): 1010-1020.

De Ruysscher D., Niedermann G., Burnet N.G., Siva S., Lee W.M.A. and Hegi-Johnson F., Radiotherapy toxicity, Nature Reviews Disease Primers. 2019, 5.

Le Q.T., Colevas A.D., O’Sullivan B., Lee W.M.A., Lee N., Ma B., Siu L.L., Waldron J., Lim C.M., Riaz N., Lynn J. and Malik S., Current Treatment Landscape of Nasopharyngeal Carcinoma and Potential Trials Evaluating the Value of Immunotherapy, JNCI: Journal of the National Cancer Institute. 2019, 111: 655-663.

Le Q.T., Yom S.S., Wee J.T.S., Lee W.M.A., Grau C., Grégoire V., Porceddu S., Welch J.J. and Mehanna H., In Regard to Beadle and Anderson, International Journal of Radiation Oncology*Biology*Physics. 2018, 102: 229-230.

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., O'Sullivan B., Lai V., Tong C.C., Lam K.O., Ng C.Y., Chan S.Y., Ho P.Y.P., Chan W.L.W., Leung D.K., Chan S.K., Tsang K.C., Khong P.L., Luk M.Y. and Lee W.M.A., 5-Year Results of the Prognostic Roles of Serial Post-Intensity-Modulated Radiation Therapy Undetectable Plasma EBV DNA for Non-Metastatic Nasopharyngeal Carcinoma, International Journal of Radiation Oncology*Biology*Physics. 2018, 102: S126-S127.

Lee V.H.F., Lam K.O., Chang T.Y.A., Lam T.C., Chiang C.L., So T.H., Choi C.W. and Lee W.M.A., Management of Nasopharyngeal Carcinoma: Is Adjuvant Therapy Needed?, Journal of Oncology Practice. 2018, 14: 594-602.

Lee V.H.F., Lam K.O. and Lee W.M.A., Standard of Care for Nasopharyngeal Carcinoma (2018–2020), Nasopharyngeal Carcinoma. Elsevier, 2019, 205-238.

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., O'Sullivan B., Lam K.O., Lai V., Khong P.L., Chan S.K., Ng C.Y., Tong C.C., Ho P.Y.P., Chan W.L.W., Wong L.S., Leung D.K.C., Chan S.Y., So T.H., Luk M.Y. and Lee W.M.A., The addition of pretreatment plasma Epstein-Barr virus DNA into the 8th edition of nasopharyngeal cancer TNM stage classification, International Journal of Cancer. 2018.

Lee W.M.A., Lung M.L. and Ng W.T., 1st Edition, In: ANNE W.M. LEE, MARIA LI LUNG, WAI TONG NG, Nasopharyngeal Carcinoma: From Etiology to Clinical Practice. Elsevier Inc, 2019.

Lee W.M.A., Emerging Radiotherapy Advances in Nasopharyngeal Cancer – What to Expect in the Next Decade?, Nasopharyngeal Cancer Workshop 2019, The HEAD Foundation Singapore, 25-26 January 2019, Singapore. 2019.

Lee W.M.A., Evaluation Of The Global Pattern Of Cancer Survival And The Correlation With Healthcare Expenditures, UICC, World Cancer Congress 2018, 30 September – 4 October 2018, Kuala Lumpur. 2018.

Lee W.M.A., First Prize of Science and Technology Award, Fujian Government. 2018.

Lee W.M.A., Honorary Fellow, American College of Radiology. 2019.

Lee W.M.A., IAEA Project (E33039): to Improve Outcome for NPC – Background & Design of Study, Second Research Coordination Meeting on Improving Radiotherapy Treatment Planning for Patients with Nasopharyngeal Carcinoma in Low- and Middle-Income Countries, the International Atomic Energy Agency (IAEA), 4-6 March 2019, Vienna, Austria. 2019.

Lee W.M.A., IAEA Project (E33039): to Improve Outcome for NPC – Clinical Study on quality of Treatment Preliminary Data from 1st Phase (Baseline Assessment), Second Research Coordination Meeting on Improving Radiotherapy Treatment Planning for Patients with Nasopharyngeal Carcinoma in Low- and Middle-Income Countries, the International Atomic Energy Agency (IAEA), 4-6 March 2019, Vienna, Austria. 2019.

Lee W.M.A., IAEA Project (E33039): to Improve Outcome for NPC – Recommendations on CTV Contouring, Dose Prioritization & Constraints, Second Research Coordination Meeting on Improving Radiotherapy Treatment Planning for Patients with Nasopharyngeal Carcinoma in Low- and Middle-Income Countries, the International Atomic Energy Agency (IAEA), 4-6 March 2019, Vienna, Austria. 2019.

Lee W.M.A., IAEA Project (E33039): to Improve Outcome for NPC – Recommendations on Dose Fractionation & Imaging, Second Research Coordination Meeting on Improving Radiotherapy Treatment Planning for Patients with Nasopharyngeal Carcinoma in Low- and Middle-Income Countries, the International Atomic Energy Agency (IAEA), 4-6 March 2019, Vienna, Austria. 2019.

Lee W.M.A., International Consensus of CTV Delineation, The 6th Asian Society of Head & Neck Oncology 2019, 27-30 March 2019, Seoul, South Korea. 2019.

Lee W.M.A., Zong J.F., Pam J.J., Choi C.W. and Sze H.C.K., Staging of Nasopharyngeal Carcinoma Based on the 8th Edition of the AJCC/UICC Staging System, Nasopharyngeal Carcinoma. Elsevier, 2019, 179-203.

Lee W.M.A., The Battle against Nasopharyngeal Cancer, The 1st International Conference of Nasopharyngeal Carcinoma 2018, University Sumatera Utara, 6-7 December 2018, Indonesia. 2018.

Lee W.M.A., The Strengths and Weaknesses of EBV-DNA as a biomarker for Nasopharyngeal Cancer, The 6th Asian Society of Head & Neck Oncology 2019, 27-30 March 2019, Seoul, South Korea. 2019.

Liu X., Zhang Y., Tang L.L., Le Q.T., Chua M.L.K., Wee J.T.S., Lee N.Y., O’Sullivan B., Lee W.M.A., Sun Y. and Ma J., Characteristics of Radiotherapy Trials Compared With Other Oncological Clinical Trials in the Past 10 Years, JAMA Oncology. 2018, 4: 1073.

Mai Z., Lin J., Ngan K.C.R., Kwong D.L.W., Ng W.T., Ng A.W.Y., Yuen K.T., Ip D.K.M., Chan Y.H., Lee W.M.A., Ho D.S.Y., Lung M.L. and Lam T.H., Milk consumption across life periods in relation to lower risk of nasopharyngeal carcinoma: A multicentre case-control study, Frontiers in Oncology. 2019, 9: 253.

Mendenhall W.M., Suárez C., Genden E.M., de Bree R., Strojan P., Langendijk J.A., Mäkitie A.A., Smee R., Eisbruch A., Lee W.M.A., Rinaldo A. and Ferlito A., Parameters Associated With Mandibular Osteoradionecrosis, American Journal of Clinical Oncology. 2018, 41: 1276-1280.

Mendenhall W.M., Strojan P., Beitler J.J., Langendijk J.A., Suarez C., Lee W.M.A., Rinaldo A., Rodrigo J.P., Smee R., Eisbruch A., Harrison L.B., Corry J. and Ferlito A., Radiotherapy for parapharyngeal space tumors, American Journal of Otolaryngology. 2019, 40: 289-291.

Researcher : Lei CL

List of Research Outputs

Ko J.M.Y., Vardhanabhuti V., Ng W.T., Lam K.O., Ngan K.C.R., Kwong D.L.W., Lee V.H.F., Lui Y.H., Yau C.C., Kwan C.K., Li W.S., Yau S., Guo C., Choi S.S.A., Lei C.L., Chan K.C., Lam C.S.C., Chang C.K.C., Dai W., Khong P.L. and Lung M.L., In: Gordon Research Conference on Translational Cancer Genomics. Hong Kong. June 30-July 5, 2019., Complementary role of circulating tumor cell and cfDNA improves detection of minimal residual disease in metastatic nasopharyngeal carcinoma.. 2019.

Researcher : Leong ML

List of Research Outputs

Researcher : Leung TW

List of Research Outputs

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., O'Sullivan B., Lai V., Tong C.C., Lam K.O., Ng C.Y., Chan S.Y., Ho P.Y.P., Chan W.L.W., Leung D.K., Chan S.K., Tsang K.C., Khong P.L., Luk M.Y. and Lee W.M.A., 5-Year Results of the Prognostic Roles of Serial Post-Intensity-Modulated Radiation Therapy Undetectable Plasma EBV DNA for Non-Metastatic Nasopharyngeal Carcinoma, International Journal of Radiation Oncology*Biology*Physics. 2018, 102: S126-S127.

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., O'Sullivan B., Lam K.O., Lai V., Khong P.L., Chan S.K., Ng C.Y., Tong C.C., Ho P.Y.P., Chan W.L.W., Wong L.S., Leung D.K.C., Chan S.Y., So T.H., Luk M.Y. and Lee W.M.A., The addition of pretreatment plasma Epstein-Barr virus DNA into the 8th edition of nasopharyngeal cancer TNM stage classification, International Journal of Cancer. 2018.

Wong C.L.T., Chiang C.L., Lee A.S., Lee V.H.F., Yeung C.S.Y., Ho C.H.M., Cheung T.T., Ng K.C.K., Chok K.S.H., Chan A.C.Y., Dai W.C., Wong F.C.S., Luk M.Y., Leung T.W. and Lo C.M., Better survival after stereotactic body radiation therapy following transarterial chemoembolization in nonresectable hepatocellular carcinoma: A propensity score matched analysis, Surgical Oncology. 2019, 28: 228-235.

Wong C.L.T., Lee V.H.F., Law A.H., Cui T.Y., Fung J.Y.Y., Sin S.L., Chan A.C.Y., Dai W.C., Chok K.S.H., Cheung T.T., Ng K.C.K., Leung T.W. and Lo C.M., Prospective study of stereotactic body radiation therapy as a bridging therapy for hepatocellular carcinoma patients on waiting list for liver transplantation., International Liver Transplant Society 25th Annual Congress, Toronto, Canada, 15-18 May 2019 . 2019.

Researcher : Li J

List of Research Outputs

Li J., Ko J.M.Y., Dai W., Ning L., Ng H.Y., Yu V.Z.Y. and Lung M.L., Functional Characterization of Pol in esophageal squamous cell carcinoma., 110th American Association Cancer Research Annual Meeting, Atlanta, Georgia, USA. March 29- April 3, 2019.. 2019.

Li Y., Lin S., Li L., Tang Z., Hu Y., Ban X., Zeng T., Zhou Y., Zhu Y.H., Gao S., Deng W., Zhang X., Xie D., Yuan Y., Huang P., Li J., Cai Z. and Guan X., PDSS2 deficiency induces hepatocarcinogenesis by decreasing mitochondrial respiration activity and reprogramming glucose metabolism, Cancer Research. 2018, 78(16): 4471-4481.

Researcher : Li L

List of Research Outputs

Zheng Y.L., Li L., Jia Y., Zhang B.Z., Li J.C., Zhu Y.H., Li M.Q., HE J., Zeng T.T., Ban X.J., Yuan Y.F., Li Y. and Guan X., LINC01554-mediated glucose metabolism reprogramming suppresses tumorigenicity in hepatocellular carcinoma via downregulating PKM2 Expression and Inhibiting Akt/mTOR Signaling Pathway, Theranostics. 2019, 9(3): 796-810.

Researcher : Li Y

List of Research Outputs

Fang S., Liu M., Li L., ZHANG F., Li Y., CUI Y., Zhu Y.H., Yuan Y.F. and Guan X., Lymphoid enhancer-binding factor-1 promotes stemness and poor differentiation of hepatocellular carcinoma by directly activating the NOTCH pathway, Oncogene. 2019, 38(21): 4061-4074.

Li L., Li J., Yang H., Zhang X., Liu L., Li Y., Zeng T., Zhu Y.H., Li X.D., Li Y., Xie D., Fu L. and Guan X., Expansion of cancer stem cell pool initiates lung cancer recurrence before angiogenesis, Proc Natl Acad Sci USA . 2018, 115(38): E8948-E8957.

SIN T.K., Li Y., Liu M., Ma S.K.Y. and Guan X., TROP-2 exhibits tumor suppressive functions in cervical cancer by dual inhibition of IGF-1R and ALK signaling, Gynecol Oncol. 2019, 152(1): 185-193.

Sin S.T., Li Y., Liu M., Yuan Y.F., Ma S.K.Y. and Guan X., Down-regulation of TROP-2 predicts poor prognosis of hepatocellular carcinoma patients, Hepatology Communications. 2018.

Researcher : Liu M

List of Research Outputs

Fang S., Liu M., Li L., ZHANG F., Li Y., CUI Y., Zhu Y.H., Yuan Y.F. and Guan X., Lymphoid enhancer-binding factor-1 promotes stemness and poor differentiation of hepatocellular carcinoma by directly activating the NOTCH pathway, Oncogene. 2019, 38(21): 4061-4074.

SIN T.K., Li Y., Liu M., Ma S.K.Y. and Guan X., TROP-2 exhibits tumor suppressive functions in cervical cancer by dual inhibition of IGF-1R and ALK signaling, Gynecol Oncol. 2019, 152(1): 185-193.

Sin S.T., Li Y., Liu M., Yuan Y.F., Ma S.K.Y. and Guan X., Down-regulation of TROP-2 predicts poor prognosis of hepatocellular carcinoma patients, Hepatology Communications. 2018.

Researcher : Liu WMR

List of Research Outputs

Tang H., Jiang L., Zhu C., Liu W.M.R., Wu Y., Yan Q., Liu M., Jia Y., Chen J., Qin Y., Lee V.H.F., Luo S., Wang Q. and Guan X., Loss of cell adhesion molecule L1 like promotes tumor growth and metastasis in esophageal squamous cell carcinoma, Oncogene. 2019.

Researcher : Luk MY

List of Research Outputs

Lam K.O., Tong C.C., Lee V.H.F., Luk M.Y. and Lam C.W., DPYD genotype-guided dose individualisation of fluoropyrimidine therapy: who and how?, The Lancet Oncology. 2019, 20: e66.

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., O'Sullivan B., Lai V., Tong C.C., Lam K.O., Ng C.Y., Chan S.Y., Ho P.Y.P., Chan W.L.W., Leung D.K., Chan S.K., Tsang K.C., Khong P.L., Luk M.Y. and Lee W.M.A., 5-Year Results of the Prognostic Roles of Serial Post-Intensity-Modulated Radiation Therapy Undetectable Plasma EBV DNA for Non-Metastatic Nasopharyngeal Carcinoma, International Journal of Radiation Oncology*Biology*Physics. 2018, 102: S126-S127.

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., O'Sullivan B., Lam K.O., Lai V., Khong P.L., Chan S.K., Ng C.Y., Tong C.C., Ho P.Y.P., Chan W.L.W., Wong L.S., Leung D.K.C., Chan S.Y., So T.H., Luk M.Y. and Lee W.M.A., The addition of pretreatment plasma Epstein-Barr virus DNA into the 8th edition of nasopharyngeal cancer TNM stage classification, International Journal of Cancer. 2018.

Tong C.C., Lam C.W., Lam K.O., Lee V.H.F. and Luk M.Y., A Novel DPYD Variant Associated With Severe Toxicity of Fluoropyrimidines: Role of Pre-emptive DPYD Genotype Screening, Frontiers in Oncology. 2018, 8.

Wong C.L.T., Chiang C.L., Lee A.S., Lee V.H.F., Yeung C.S.Y., Ho C.H.M., Cheung T.T., Ng K.C.K., Chok K.S.H., Chan A.C.Y., Dai W.C., Wong F.C.S., Luk M.Y., Leung T.W. and Lo C.M., Better survival after stereotactic body radiation therapy following transarterial chemoembolization in nonresectable hepatocellular carcinoma: A propensity score matched analysis, Surgical Oncology. 2019, 28: 228-235.

Researcher : Lung HL

Project Title:	The serum amyloid A1 (SAA1) Polymorphisms as Risk Factors in Esophageal Squamous Cell Carcinoma
Investigator(s):	Lung HL, Lung ML, Law SYK
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	11/2013

Project Title:	The effects of the IKKbeta-specific inhibitor PS1145 on tumor formation and metastasis in nasopharyngeal carcinoma
Investigator(s):	Lung HL, Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	02/2015

List of Research Outputs

Chan L.S., Man O.Y., Kwok H.H., Chen L., Chan K.C., Lung H.L., Ngan K.C.R., Wong R.N.S., Lo K.W., Lee W.M.A., Tsao G.S.W., Kahn M., Lung M.L. and Mak N.K., The Wnt modulator ICG‑001 mediates the inhibition of nasopharyngeal carcinoma cell migration in vitro via the miR‑150/CD44 axis., Int J Oncol.. 2018, 54(3): 1010-1020.

Zhang J., Jia L.J., Liu T.E.N.G.F.E.I., Yip Y.L., Tang W.C., Lin W., Deng W., Lo K.W.O.K. .W.A.I., You C., Lung M.L., Lung H.L., Tsao G.S.W., Cheung A. and Tsang C.M., mTORC2-mediated PDHE1α nuclear translocation links EBV-LMP1 reprogrammed glucose metabolism to cancer metastasis in nasopharyngeal carcinoma., Oncogene. 2019, 38(24): 4669-4684.

Researcher : Lung ML

Project Title:	Candidate tumor suppressor gene, DUSP6, involvement in esophageal and nasopharyngeal carcinomas
Investigator(s):	Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2009

Project Title:	Centre for Nasopharyngeal Carcinoma Research
Investigator(s):	Lung ML, Chen H, Chiang AKS, Khong PL, Kwong DLW, Guan X, Tsao GSW, Wu EX, Lee WMA, Chan JPH, Jin D, Lam TH, Nicholls JM, Sham JST, Tu W, Sham PC, Cherny SS, Yang W, Lam TC, Lam KO, Lee VHF
Department:	Clinical Oncology
Source(s) of Funding:	Areas of Excellence Scheme
Start Date:	01/2010
Completion Date:	12/2019

Project Title:	Advances in Nasopharyngeal Carcinoma Studies
Investigator(s):	Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	Croucher Advanced Study Institute
Start Date:	11/2014

Project Title:	Functional and Mechanistic Investigation of Frequent p53 Gain-of-Function Mutations in Esophageal Squamous Cell Carcinoma
Investigator(s):	Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2015
Completion Date:	08/2018

Project Title:	Functional and mechanistic characterizations of a Candidate Tumor Suppressor Gene, Mirror Image Polydactyly 1, in Nasopharyngeal Carcinoma
Investigator(s):	Lung ML
Department:	Clinical Oncology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2015
Completion Date:	08/2018

Project Title:	Regulation and Clinical Implication of PD-L1 Expression in Esophageal Tumor Cells subjected to Chemotherapy
Investigator(s):	Lung ML, Ko JMY, Yu Z
Department:	Clinical Oncology
Source(s) of Funding:	Matching Grant for Joint Research
Start Date:	11/2015

Project Title:	Targeted Genomics and Functional Studies of Novel Cancer Predisposing Genes for Esophageal Squamous Cell Carcinoma
Investigator(s):	Lung ML, Chan KW, Law SYK, Song Y
Department:	Clinical Oncology
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2016

Project Title:	Establishing platform technology for use of circulating tumor cells for cancer diagnostics and drug testing
Investigator(s):	Lung ML, Ko JMY, Dai W
Department:	Clinical Oncology
Source(s) of Funding:	Platform Technology Funding
Start Date:	06/2017
Completion Date:	06/2019

Project Title:	Translational Studies for Elucidating the Tumor Heterogeneity and Molecular Evolution in Metastatic Gastrointestinal Tract Cancers for Personalized Medicine
Investigator(s):	Lung ML, Kwong DLW, Lam KO, Law SYK, Sham PC, Lo WIA
Department:	Clinical Oncology
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	11/2017

Project Title:	Non-invasive Real-time Monitoring and Next-generation Sequencing of Circulating Tumor Cells for Improved Personalized Treatment of Metastatic Colorectal Cancer Patients
Investigator(s):	Lung ML, Lam KO, Ko JMY, Dai W
Department:	Clinical Oncology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	03/2018

Project Title:	Clinical application of enumeration and genomic characterization for non-invasive detection and real-time monitoring of circulating tumor cells for esophageal carcinoma
Investigator(s):	Lung ML, Law SYK, Kwong DLW, Lam KO, Chan KW, Chiu WHK, Ko JMY, Dai W
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2018

List of Research Outputs

CHOI S.S...A., Dai W., Yu V.Z.Y., Ko J.M.Y. and Lung M.L., Functional Characterization of ZNF750 in esophageal squamous cell carcinoma., 110th American Association Cancer Research Annual Meeting, Atlanta, Georgia, USA. March 29- April 3, 2019.. 2019.

Chan L.S., Man O.Y., Kwok H.H., Chen L., Chan K.C., Lung H.L., Ngan K.C.R., Wong R.N.S., Lo K.W., Lee W.M.A., Tsao G.S.W., Kahn M., Lung M.L. and Mak N.K., The Wnt modulator ICG‑001 mediates the inhibition of nasopharyngeal carcinoma cell migration in vitro via the miR‑150/CD44 axis., Int J Oncol.. 2018, 54(3): 1010-1020.

Chan T.F., Hui K.F., Yang W., Shen J.J., Lam K.P., Kwok H., Sham P.C., Tsao G.S.W., Kwong D.L.W., Lung M.L. and Chiang A.K.S., Genome-wide analysis identifies high-risk Epstein-Barr virus associated with nasopharyngeal carcinoma., HKU Research Postgraduate Seminar, December 5-7, 2018.. 2018.

Chen H.L., Ji M., Zong J.F., Ko J.M.Y., Dai W. and Lung M.L., Conventional and novel diagnostic biomarkers and approaches for detection of nasopharyngeal carcinoma., Nasopharyngeal Carcinoma: Etiology to Clinical Practice. Elsevier AP, 2019, 129-153.

DENG M., Cheung A.K.L., Dai W., Yu V.Z.Y. and Lung M.L., In: 110th American Association Cancer Research Annual Meeting, Atlanta, Georgia, USA. March 29- April 3, 2019., Functional and molecular analysis of the somatic mutations in NF-ĸB pathway inhibitor, CYLD, in nasopharyngeal carcinoma.. 2019.

Dai W., Ko J.M.Y., Ng H.Y. and Lung M.L., Genomic Profiles to Identify the Key Events in Metastasis for Esophageal Squamous Cell Carcinoma, Gordon Research Conference on Translational Cancer Genomics. June 30-July 5, Hong Kong. 2019.

Hui K.F., CHAN T.F., Yang W., Shen J.J., Lam K.P., Kwok H.I.N., Sham P.C., Tsao G.S.W., Kwong D.L.W., Lung M.L. and Chiang A.K.S., High risk Epstein‐Barr virus variants characterized by distinct polymorphisms in the EBER locus are strongly associated with nasopharyngeal carcinoma, International Journal of Cancer. 2019, 144: 3031-3042.

JIANG C., CHEN J., Xie S., Zhang L., Xiang Y., Lung M.L., Kam N.W., Kwong D.L.W., Cao S. and Guan X., Evaluation of circulating EBV microRNA BART2-5p in facilitating early detection and screening of nasopharyngeal carcinoma, International Journal of Cancer. 2018.

Ko J.M.Y., Vardhanabhuti V., Ng W.T., Lam K.O., Ngan K.C.R., Kwong D.L.W., Lee V.H.F., Lui Y.H., Yau C.C., Kwan C.K., Li W.S., Yau S., Guo C., Choi S.S.A., Lei C.L., Chan K.C., Lam C.S.C., Chang C.K.C., Dai W., Khong P.L. and Lung M.L., In: Gordon Research Conference on Translational Cancer Genomics. Hong Kong. June 30-July 5, 2019., Complementary role of circulating tumor cell and cfDNA improves detection of minimal residual disease in metastatic nasopharyngeal carcinoma.. 2019.

LEI C., Yu V.Z.Y., Ning L., Ko J.M.Y., Wang L.D. and Lung M.L., FANCD2 deletion suppresses tumor growth in esophageal squamous cell carcinoma., 110th American Association Cancer Research Annual Meeting, Atlanta, Georgia, USA. March 29- April 3, 2019.. 2019.

LEONG M.L., Cheung A.K.L., Dai W., Tsao G.S.W. and Lung M.L., EBV-associated histone modifications in the regulation of DNA damage repair members resulting in cisplatin resistance in nasopharyngeal carcinoma, The 77th Annual Meeting of the Japanese Cancer Association. Osaka, Japan, Sept 27-29, 2018.

Lam C.S.C., Dai W., Ko J.M.Y. and Lung M.L., Evaluation of Two Next- Generation Sequencing Platforms for Genomic Analysis in Circulating Tumor Cells., 110th American Association Cancer Research Annual Meeting, Atlanta, Georgia, USA.. 2019.

Lam C.S.C. and Lung M.L., Utilizing Next Generation Sequencing Technologies for Sequencing Circulating Tumor Cells., Research Postgraduate Symposium, Hong Kong. 2018.

Lee A.W.M., Lung M.L. and Ng W.T., Nasopharyngeal carcinoma: From etiology to clinical practice., Co-editor. Elsevier Academic Press. Elsevier, 2019.

Lee W.M.A., Lung M.L. and Ng W.T., 1st Edition, In: ANNE W.M. LEE, MARIA LI LUNG, WAI TONG NG, Nasopharyngeal Carcinoma: From Etiology to Clinical Practice. Elsevier Inc, 2019.

Leong M.L., Cheung A.K.L., Dai W., Tsao G.S.W., Dawson C.W. and Lung M.L., EBV modulates histone H3K4me3 and H3K27me3 bivalent switch to suppress DNA damage repair pathway members in epithelial cells., PNAS 2019. 2019.

Leong M.L., Cheung A.K.L., Dai W., Tsao G.S.W. and Lung M.L., EBV-associated bivalent histone modifications regulate DNA damage repair and cisplatin resistance in epithelial malignancy., 110th American Association Cancer Research Annual Meeting, Atlanta, Georgia, USA. March 29- April 3, 2019.. 2019.

Li B., Hong P., Zheng C.C., Dai W., Chen W.Y., Yang Q.S., Han L., Tsao G.S.W., Chan K.T., Lee N.P.Y., Law S.K., Xu L.Y., Li E.M., Chan K.W., Qin Y.R., Guan X., Lung M.L., He Q.Y., Xu W.W. and Cheung A., Identification of miR-29c and its Target FBXO31 as a Key Regulatory Mechanism in Esophageal Cancer Chemoresistance: Functional Validation and Clinical Significance., Theranostics 2019. 2019, 9(6):1599-1613.

Li B., Hong P., Zheng C.-.C., Dai W., Chen W.-.Y., Yang Q.-.S., HAN L., Tsao G.S.W., Chan K.T., Lee N.P.Y., Law S.Y.K., Xu L.Y., Li E.M., Chan K.W., Qin Y.R., Guan X., Lung M.L., He Q.-.Y., Xu W. and Cheung A., Identification of miR-29c and its Target FBXO31 as a Key Regulatory Mechanism in Esophageal Cancer Chemoresistance: Functional Validation and Clinical Significance, Theranostics. 2019, 9: 1599-1613.

Li J., Ko J.M.Y., Dai W., Ning L., Ng H.Y., Yu V.Z.Y. and Lung M.L., Functional Characterization of Pol in esophageal squamous cell carcinoma., 110th American Association Cancer Research Annual Meeting, Atlanta, Georgia, USA. March 29- April 3, 2019.. 2019.

Lin W., Yip Y.L., Jia L.J., Deng W., Zheng H., Dai W., Ko J.M.Y., Lo K.W., Chung G.T.Y., Yip K.Y., Lee S.D., Kwan J.S.H., Zhang J., Liu T.F., Chan Y.W., Kwong D.L.W., Lee V.H.F., Nicholls J.M., Busson P., Liu X.F., Chiang A.K.S., Hui K.F., Kwok H., Cheung S.T., Cheung Y.C., Chan C.K., Li B., Cheung A., Hau P.M., Zhou Y., Tsang C.M., Middeldorp J., Chen H., Lung M.L. and Tsao G.S.W., Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma, Nature Communications. 2018, 7; 9(1): 4663.

Lung M.L., (Co-I), GRF research grant, “Genomic and functional study by targeting MST1R and its related chromosome 3p21.3 regions associated with genetic susceptibility in NPC” HK$956,853, Research Grants Council. 2019.

Lung M.L., (Co-I), Research grant, “Establishment of a patient-derived organoid in vivo drug testing model in ESCC and a pilot study for tumor-associated macrophage targeted therapy” HK$1,484,832, Health Medical Research Fund. 2019.

Lung M.L., EBV-associated histone bivalent switch suppresses expression of DNA damage repair members in normal nasopharyngeal epithelial cells. NPC mini-symposium. Fujian Tumor Hospital. Invited Speaker. June 24-25, 2019., 2019.

Lung M.L., Identification of genetic factors for esophageal squamous cell carcinoma by large-scale targeted region sequencing. Gordon Research Conference on Translational Cancer Genomics. Hong Kong, June 30-July 4, 2019., 2019.

Lung M.L., Dai W. and Ko J.M.Y., Nasopharyngeal carcinoma: genetics and genomics. Nasopharyngeal Carcinoma., Etiology to Clinical Practice. Elsevier AP, 2019, 17-44.

Lung M.L., New insights in cancer detection utilizing CTC enumeration and next-generation sequencing analysis, 2018 Chinese Conference on Oncology. Shenyang, PRC, Aug 17, 2018. 2018.

Lung M.L., West Lake Forum on Oncology. Development of NGS approaches to utilize cancer circulating tumor cell analysis to identify gene signatures associated with treatment responses. Hangzhou, China, Jun 27, 2019., 2019.

Mai Z., Lin J., Ngan K.C.R., Kwong D.L.W., Ng W.T., Ng A.W.Y., Yuen K.T., Ip D.K.M., Chan Y.H., Lee W.M.A., Ho D.S.Y., Lung M.L. and Lam T.H., Milk consumption across life periods in relation to lower risk of nasopharyngeal carcinoma: A multicentre case-control study, Frontiers in Oncology. 2019, 9: 253.

Ning L., Ko J.M.Y. and Lung M.L., Validation of CDKN2B-AS1 in nasopharyngeal carcinoma genetic susceptibility by targeted sequencing, Gordon Research Conference on Translational Cancer Genomics. 2019.

Zhang J., Jia L.J., Liu T.E.N.G.F.E.I., Yip Y.L., Tang W.C., Lin W., Deng W., Lo K.W.O.K. .W.A.I., You C., Lung M.L., Lung H.L., Tsao G.S.W., Cheung A. and Tsang C.M., mTORC2-mediated PDHE1α nuclear translocation links EBV-LMP1 reprogrammed glucose metabolism to cancer metastasis in nasopharyngeal carcinoma., Oncogene. 2019, 38(24): 4669-4684.

Researcher : Man OY

List of Research Outputs

Chan L.S., Man O.Y., Kwok H.H., Chen L., Chan K.C., Lung H.L., Ngan K.C.R., Wong R.N.S., Lo K.W., Lee W.M.A., Tsao G.S.W., Kahn M., Lung M.L. and Mak N.K., The Wnt modulator ICG‑001 mediates the inhibition of nasopharyngeal carcinoma cell migration in vitro via the miR‑150/CD44 axis., Int J Oncol.. 2018, 54(3): 1010-1020.

Researcher : Ng CY

List of Research Outputs

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., O'Sullivan B., Lai V., Tong C.C., Lam K.O., Ng C.Y., Chan S.Y., Ho P.Y.P., Chan W.L.W., Leung D.K., Chan S.K., Tsang K.C., Khong P.L., Luk M.Y. and Lee W.M.A., 5-Year Results of the Prognostic Roles of Serial Post-Intensity-Modulated Radiation Therapy Undetectable Plasma EBV DNA for Non-Metastatic Nasopharyngeal Carcinoma, International Journal of Radiation Oncology*Biology*Physics. 2018, 102: S126-S127.

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., O'Sullivan B., Lam K.O., Lai V., Khong P.L., Chan S.K., Ng C.Y., Tong C.C., Ho P.Y.P., Chan W.L.W., Wong L.S., Leung D.K.C., Chan S.Y., So T.H., Luk M.Y. and Lee W.M.A., The addition of pretreatment plasma Epstein-Barr virus DNA into the 8th edition of nasopharyngeal cancer TNM stage classification, International Journal of Cancer. 2018.

Researcher : Ng HY

Project Title:	25th Biennial Congress of the European Association for Cancer Reserach; Chemotherapy induces PD-L1 in esophageal squamous cell carcinoma
Investigator(s):	Ng HY
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2018
Completion Date:	07/2018

List of Research Outputs

Dai W., Ko J.M.Y., Ng H.Y. and Lung M.L., Genomic Profiles to Identify the Key Events in Metastasis for Esophageal Squamous Cell Carcinoma, Gordon Research Conference on Translational Cancer Genomics. June 30-July 5, Hong Kong. 2019.

Li J., Ko J.M.Y., Dai W., Ning L., Ng H.Y., Yu V.Z.Y. and Lung M.L., Functional Characterization of Pol in esophageal squamous cell carcinoma., 110th American Association Cancer Research Annual Meeting, Atlanta, Georgia, USA. March 29- April 3, 2019.. 2019.

Researcher : Ng WT

List of Research Outputs

Ko J.M.Y., Vardhanabhuti V., Ng W.T., Lam K.O., Ngan K.C.R., Kwong D.L.W., Lee V.H.F., Lui Y.H., Yau C.C., Kwan C.K., Li W.S., Yau S., Guo C., Choi S.S.A., Lei C.L., Chan K.C., Lam C.S.C., Chang C.K.C., Dai W., Khong P.L. and Lung M.L., In: Gordon Research Conference on Translational Cancer Genomics. Hong Kong. June 30-July 5, 2019., Complementary role of circulating tumor cell and cfDNA improves detection of minimal residual disease in metastatic nasopharyngeal carcinoma.. 2019.

Lee A.W.M., Lung M.L. and Ng W.T., Nasopharyngeal carcinoma: From etiology to clinical practice., Co-editor. Elsevier Academic Press. Elsevier, 2019.

Researcher : Ngan KCR

List of Research Outputs

Chan L.S., Man O.Y., Kwok H.H., Chen L., Chan K.C., Lung H.L., Ngan K.C.R., Wong R.N.S., Lo K.W., Lee W.M.A., Tsao G.S.W., Kahn M., Lung M.L. and Mak N.K., The Wnt modulator ICG‑001 mediates the inhibition of nasopharyngeal carcinoma cell migration in vitro via the miR‑150/CD44 axis., Int J Oncol.. 2018, 54(3): 1010-1020.

Ko J.M.Y., Vardhanabhuti V., Ng W.T., Lam K.O., Ngan K.C.R., Kwong D.L.W., Lee V.H.F., Lui Y.H., Yau C.C., Kwan C.K., Li W.S., Yau S., Guo C., Choi S.S.A., Lei C.L., Chan K.C., Lam C.S.C., Chang C.K.C., Dai W., Khong P.L. and Lung M.L., In: Gordon Research Conference on Translational Cancer Genomics. Hong Kong. June 30-July 5, 2019., Complementary role of circulating tumor cell and cfDNA improves detection of minimal residual disease in metastatic nasopharyngeal carcinoma.. 2019.

Kwong A., Cheng D.K.L., Hsue C.C., Hui S.K., Leung R.C.Y., Leung K.C., Ngan K.C.R. and Soong S.I., BRCA mutation testing for ovarian cancer in the context of available targeted therapy: survey and consensus of Hong Kong specialists, Asia-Pacific Journal of Clinical Oncology. 2019, 15(Suppl.): 20-31.

Mai Z., Lin J., Ngan K.C.R., Kwong D.L.W., Ng W.T., Ng A.W.Y., Yuen K.T., Ip D.K.M., Chan Y.H., Lee W.M.A., Ho D.S.Y., Lung M.L. and Lam T.H., Milk consumption across life periods in relation to lower risk of nasopharyngeal carcinoma: A multicentre case-control study, Frontiers in Oncology. 2019, 9: 253.

Ngan K.C.R., Adapting new management strategy in luminal ABC in Asian patients - a HKBOG experience, Asia-Pacific Summit 2018, Taipei, Taiwan, 14-15 July 2018. 2018.

Researcher : Ning L

List of Research Outputs

LEI C., Yu V.Z.Y., Ning L., Ko J.M.Y., Wang L.D. and Lung M.L., FANCD2 deletion suppresses tumor growth in esophageal squamous cell carcinoma., 110th American Association Cancer Research Annual Meeting, Atlanta, Georgia, USA. March 29- April 3, 2019.. 2019.

Li J., Ko J.M.Y., Dai W., Ning L., Ng H.Y., Yu V.Z.Y. and Lung M.L., Functional Characterization of Pol in esophageal squamous cell carcinoma., 110th American Association Cancer Research Annual Meeting, Atlanta, Georgia, USA. March 29- April 3, 2019.. 2019.

Ning L., Ko J.M.Y. and Lung M.L., Validation of CDKN2B-AS1 in nasopharyngeal carcinoma genetic susceptibility by targeted sequencing, Gordon Research Conference on Translational Cancer Genomics. 2019.

Researcher : SIN TK

List of Research Outputs

SIN T.K., Li Y., Liu M., Ma S.K.Y. and Guan X., TROP-2 exhibits tumor suppressive functions in cervical cancer by dual inhibition of IGF-1R and ALK signaling, Gynecol Oncol. 2019, 152(1): 185-193.

Researcher : Shum CYT

List of Research Outputs

Hou W.K., Lau K.M., Shum C.Y.T., Cheng C.K. and Lee T.M.C., Do concordances of social support and relationship quality predict psychological distress and well-being of cancer patients and caregivers?, European Journal of Cancer Care. 2018, 27: e12857.

Researcher : So TH

List of Research Outputs

Lam K.O., Chan W.L.W., So T.H., Lee V.H.F. and Kwong D.L.W., Third-line Systemic Treatment In Advanced/metastatic Gastric Cancer: A Comprehensive Review., Ther Adv Med Oncol. 2019.

Lee V.H.F., Lam K.O., Chang T.Y.A., Lam T.C., Chiang C.L., So T.H., Choi C.W. and Lee W.M.A., Management of Nasopharyngeal Carcinoma: Is Adjuvant Therapy Needed?, Journal of Oncology Practice. 2018, 14: 594-602.

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., O'Sullivan B., Lam K.O., Lai V., Khong P.L., Chan S.K., Ng C.Y., Tong C.C., Ho P.Y.P., Chan W.L.W., Wong L.S., Leung D.K.C., Chan S.Y., So T.H., Luk M.Y. and Lee W.M.A., The addition of pretreatment plasma Epstein-Barr virus DNA into the 8th edition of nasopharyngeal cancer TNM stage classification, International Journal of Cancer. 2018.

So T.H., Chan S.K., Lee V.H.F., Chen B.Z., Kong F.P. and Lao L., Chinese Medicine in Cancer Treatment -How is it Practiced in the East and the West?, Clinical Oncology . 2019, 31: 578–588.

So T.H., the Gold Award, Royal College of Radiologists . 2018.

Wong Y.H.I., Lam K.O., Chan W.L.W., Wong L.Y.C., So T.H., Chan K.K.D., Choi C.W., Law T.T., Chiu W.H.K., Chan S.Y., Kwong D.L.W. and Law S.Y.K., Real World Scenario: CROSS regimen as preoperative therapy for esophageal squamous cell carcinoma (Abstract), SSAT Plenary Session: Esophagus and Gastric II, Digestive Disease Week (DDW 2019), San Diego, USA, 18-21 May. 2019.

Researcher : Soong SI

List of Research Outputs

Kwong A., Cheng D.K.L., Hsue C.C., Hui S.K., Leung R.C.Y., Leung K.C., Ngan K.C.R. and Soong S.I., BRCA mutation testing for ovarian cancer in the context of available targeted therapy: survey and consensus of Hong Kong specialists, Asia-Pacific Journal of Clinical Oncology. 2019, 15(Suppl.): 20-31.

Zhang N., Fielding R., Soong S.I., Chan K.K.K., Lee C.C.Y., Ng A., Sze W.K., Tsang W.H.J., Lee V.H.F. and Lam W.W.T., Illness perceptions as predictors of psychological distress among head and neck cancer survivors: a longitudinal study, Head & Neck. 2018, 40: 2362-2371.

Researcher : Tang H

List of Research Outputs

Tang H., Jiang L., Zhu C., Liu W.M.R., Wu Y., Yan Q., Liu M., Jia Y., Chen J., Qin Y., Lee V.H.F., Luo S., Wang Q. and Guan X., Loss of cell adhesion molecule L1 like promotes tumor growth and metastasis in esophageal squamous cell carcinoma, Oncogene. 2019.

Researcher : Tong CC

List of Research Outputs

Lam K.O., Tong C.C., Lee V.H.F., Luk M.Y. and Lam C.W., DPYD genotype-guided dose individualisation of fluoropyrimidine therapy: who and how?, The Lancet Oncology. 2019, 20: e66.

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., O'Sullivan B., Lai V., Tong C.C., Lam K.O., Ng C.Y., Chan S.Y., Ho P.Y.P., Chan W.L.W., Leung D.K., Chan S.K., Tsang K.C., Khong P.L., Luk M.Y. and Lee W.M.A., 5-Year Results of the Prognostic Roles of Serial Post-Intensity-Modulated Radiation Therapy Undetectable Plasma EBV DNA for Non-Metastatic Nasopharyngeal Carcinoma, International Journal of Radiation Oncology*Biology*Physics. 2018, 102: S126-S127.

Lee V.H.F., Kwong D.L.W., Leung T.W., Choi C.W., O'Sullivan B., Lam K.O., Lai V., Khong P.L., Chan S.K., Ng C.Y., Tong C.C., Ho P.Y.P., Chan W.L.W., Wong L.S., Leung D.K.C., Chan S.Y., So T.H., Luk M.Y. and Lee W.M.A., The addition of pretreatment plasma Epstein-Barr virus DNA into the 8th edition of nasopharyngeal cancer TNM stage classification, International Journal of Cancer. 2018.

Tong C.C., Lam C.W., Lam K.O., Lee V.H.F. and Luk M.Y., A Novel DPYD Variant Associated With Severe Toxicity of Fluoropyrimidines: Role of Pre-emptive DPYD Genotype Screening, Frontiers in Oncology. 2018, 8.

Researcher : Tsang JWH

Project Title:	Breast Cancer Awareness, Spectrum of Breast Cancer with Particular Reference to Triple Negative Breast Cancer in the Hong Kong Chinese Population
Investigator(s):	Tsang WHJ, Chua DTT, Kwong A, Khoo US, Lam WWT
Department:	Clinical Oncology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	10/2008

Project Title:	General Awareness and Attitudes towards Cancer Clinical Trials among Cancer Patients in Hong Kong.
Investigator(s):	Tsang WHJ, Yung ST, Lam WWT
Department:	Clinical Oncology
Source(s) of Funding:	Small Project Funding
Start Date:	04/2011

Project Title:	Study of the OncotypeDx 21-gene assay and its impact on the treatment decision making process among Hong Kong Chinese breast cancer patients
Investigator(s):	Tsang WHJ, Khoo US
Department:	Clinical Oncology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	08/2012

List of Research Outputs

Researcher : Tsang WHJ

Project Title:	Breast Cancer Awareness, Spectrum of Breast Cancer with Particular Reference to Triple Negative Breast Cancer in the Hong Kong Chinese Population
Investigator(s):	Tsang WHJ, Chua DTT, Kwong A, Khoo US, Lam WWT
Department:	Clinical Oncology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	10/2008

Project Title:	General Awareness and Attitudes towards Cancer Clinical Trials among Cancer Patients in Hong Kong.
Investigator(s):	Tsang WHJ, Yung ST, Lam WWT
Department:	Clinical Oncology
Source(s) of Funding:	Small Project Funding
Start Date:	04/2011

Project Title:	Study of the OncotypeDx 21-gene assay and its impact on the treatment decision making process among Hong Kong Chinese breast cancer patients
Investigator(s):	Tsang WHJ, Khoo US
Department:	Clinical Oncology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	08/2012

List of Research Outputs

Zhang N., Fielding R., Soong S.I., Chan K.K.K., Lee C.C.Y., Ng A., Sze W.K., Tsang W.H.J., Lee V.H.F. and Lam W.W.T., Illness perceptions as predictors of psychological distress among head and neck cancer survivors: a longitudinal study, Head & Neck. 2018, 40: 2362-2371.

Researcher : Tsao GSW

Project Title:	The role of TGF-beta in EBV infection and pathogenesis of nasopharyngeal carcinoma
Investigator(s):	Tsao GSW, Lan HY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Small Project Funding
Start Date:	01/2009

Project Title:	Systematic Development of Molecular Targets for Nasopharyngeal Carcinoma
Investigator(s):	Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	01/2014
Completion Date:	12/2018

Project Title:	Establishment of a shared live cell imaging platform for super-resolution microscopy
Investigator(s):	Tsao GSW, Bruzzone R, Chang RCC, Cheung MCH, Ching YP, Huen MSY, Jin D, Yang D, Yu C, Yuen KWY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Major Equipment Project
Start Date:	06/2015

Project Title:	Advanced Imaging - From System Biology to Single Cell & Single Molecule Analysis
Investigator(s):	Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Croucher Summer Courses
Start Date:	07/2015

Project Title:	Biomimetic 3D Microsystem to Study Tumour Survival and Drug Responses
Investigator(s):	Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2016

Project Title:	Immortalization of nasopharyngeal epithelial cells by the EBV-encoded LMP1
Investigator(s):	Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2016

Project Title:	Role of IL-6/IL-6Rα signaling activation in supporting persistent EBV infection in premalignant nasopharyngeal epithelial cells
Investigator(s):	Tsao GSW, Deng W
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

Project Title:	High speed and high-sensitivity fluorescent live cell imaging system
Investigator(s):	Tsao GSW, Yu C
Department:	School of Biomedical Sciences
Source(s) of Funding:	Small Equipment Grant
Start Date:	06/2017

Project Title:	Preclinical evaluation of therapeutic use of a selective cdk4/6 inhibitor (PD-0332991) in nasopharyngeal carcinoma (NPC).
Investigator(s):	Tsao GSW, Lui WYV, Lee WMA
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2017

Project Title:	Regulation and pathogenic role of latent infection of Epstein-Barr virus in nasopharyngeal carcinoma
Investigator(s):	Tsao GSW, Chen H, Jin D, Kok KH
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2017

Project Title:	Deciphering multiple mechanisms underlying the retention of Epstein-Barr viruses in nasopharyngeal carcinoma cells
Investigator(s):	Tsao GSW, Deng W
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2018

Project Title:	Pathogenicity of EBV isolated from nasopharyngeal carcinoma
Investigator(s):	Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2019

Project Title:	A mechanistic and clinicopathological study on the impact of invadosomes in promoting nasopharyngeal carcinoma (NPC) metastasis under the interplay of stromal macrophages and EBV infection
Investigator(s):	Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2019

Project Title:	American Association for Cancer Research Annual Conference; Establishment and characterization of new tumor xenografts and cancer cell lines from EBV positive nasopharyngeal carcinoma
Investigator(s):	Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2019

Project Title:	High sensitivity multi-laser flow cytometry analyzer with high throughput sample delivery system
Investigator(s):	Tsao GSW, Ma SKY
Department:	Anatomy
Source(s) of Funding:	Small Equipment Grant
Start Date:	04/2019

List of Research Outputs

Chan L.S., Man O.Y., Kwok H.H., Chen L., Chan K.C., Lung H.L., Ngan K.C.R., Wong R.N.S., Lo K.W., Lee W.M.A., Tsao G.S.W., Kahn M., Lung M.L. and Mak N.K., The Wnt modulator ICG‑001 mediates the inhibition of nasopharyngeal carcinoma cell migration in vitro via the miR‑150/CD44 axis., Int J Oncol.. 2018, 54(3): 1010-1020.

Leong M.L., Cheung A.K.L., Dai W., Tsao G.S.W., Dawson C.W. and Lung M.L., EBV modulates histone H3K4me3 and H3K27me3 bivalent switch to suppress DNA damage repair pathway members in epithelial cells., PNAS 2019. 2019.

Li B., Hong P., Zheng C.C., Dai W., Chen W.Y., Yang Q.S., Han L., Tsao G.S.W., Chan K.T., Lee N.P.Y., Law S.K., Xu L.Y., Li E.M., Chan K.W., Qin Y.R., Guan X., Lung M.L., He Q.Y., Xu W.W. and Cheung A., Identification of miR-29c and its Target FBXO31 as a Key Regulatory Mechanism in Esophageal Cancer Chemoresistance: Functional Validation and Clinical Significance., Theranostics 2019. 2019, 9(6):1599-1613.

Zhang J., Jia L.J., Liu T.E.N.G.F.E.I., Yip Y.L., Tang W.C., Lin W., Deng W., Lo K.W.O.K. .W.A.I., You C., Lung M.L., Lung H.L., Tsao G.S.W., Cheung A. and Tsang C.M., mTORC2-mediated PDHE1α nuclear translocation links EBV-LMP1 reprogrammed glucose metabolism to cancer metastasis in nasopharyngeal carcinoma., Oncogene. 2019, 38(24): 4669-4684.

Researcher : Yan Q

List of Research Outputs

Tang H., Jiang L., Zhu C., Liu W.M.R., Wu Y., Yan Q., Liu M., Jia Y., Chen J., Qin Y., Lee V.H.F., Luo S., Wang Q. and Guan X., Loss of cell adhesion molecule L1 like promotes tumor growth and metastasis in esophageal squamous cell carcinoma, Oncogene. 2019.

Researcher : Yu Z

Project Title:	Establishment of a patient-derived organoid in vivo drug testing model in esophageal squamous cell carcinoma and a pilot study for tumor-associated macrophage targeted therapy
Investigator(s):	Yu Z, Lung ML, Law SYK, Kwong DLW, Chan KC, Tao L
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2019

Researcher : ZHANG F

List of Research Outputs

Fang S., Liu M., Li L., ZHANG F., Li Y., CUI Y., Zhu Y.H., Yuan Y.F. and Guan X., Lymphoid enhancer-binding factor-1 promotes stemness and poor differentiation of hepatocellular carcinoma by directly activating the NOTCH pathway, Oncogene. 2019, 38(21): 4061-4074.

Researcher : Zheng H

List of Research Outputs

Lin W., Yip Y.L., Jia L.J., Deng W., Zheng H., Dai W., Ko J.M.Y., Lo K.W., Chung G.T.Y., Yip K.Y., Lee S.D., Kwan J.S.H., Zhang J., Liu T.F., Chan Y.W., Kwong D.L.W., Lee V.H.F., Nicholls J.M., Busson P., Liu X.F., Chiang A.K.S., Hui K.F., Kwok H., Cheung S.T., Cheung Y.C., Chan C.K., Li B., Cheung A., Hau P.M., Zhou Y., Tsang C.M., Middeldorp J., Chen H., Lung M.L. and Tsao G.S.W., Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma, Nature Communications. 2018, 7; 9(1): 4663.

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