Dept of Chemistry

DEPARTMENT OF CHEMISTRY

Researcher : Brown GD

Project Title:	Gradient diffusion-attenuated NMR spectroscopy for the analysis of multi-component mixtures
Investigator(s):	Brown GD
Department:	Chemistry
Source(s) of Funding:	Other Funding Scheme
Start Date:	12/1994

Abstract:

Spectroscopic analysis of multi-component mixtures has always required a physical separation of the components by some chromatographic technique prior to the acquisition of a characteristic spectrum from each component. In recent years there has been a poliferation of "hyphenated" techniques based on this very principle. The modern capability to generate magnetic-field gradients in NMR Spectroscopy opens up the possibility of differentiating compounds by their diffusion characteristics. The project aims to investigate whether this molecular property can be applied to resolve different components when present simultaneously in the same mixture. If successful, NMR analysis of complex mixtures would then be as simple a matter as NMR analysis of ind ividual compounds, and the need for prior chromatography will have been removed, resulting in greater simplicity and wider applicability of NMR in the analysis of multi-component mixtures.

Researcher : But YS

List of Research Outputs

But Y.S., Tashino Y., Togo H. and Toy P.H., A multipolymer system for organocatalytic alcohol oxidation, Organic and Biomolecular Chemistry. 2005, 3(6): 970-971.

Chan P.Y., Ong S.Y., But Y.S. and Phillips D.L., Time-resolved resonance Raman and density functional theory investigation of the 4-biphenylnitrene dimerization reaction, Journal of Raman Spectroscopy. 2004, 35: 887-894.

He S., Chung W.Y., But Y.S. and Toy P.H., Arsonium ylides in organic synthesis, Tetrahedron. 2005, 61(6): 1385-1405.

He S., But Y.S. and Toy P.H., Polymer-supported triphenylamine, triphenylarsine and triphenylphosphine reagents, International Conference on Heteroatom Chemistry, Shanghai, China, August 21-25, 2004.

Researcher : Chan CL

List of Research Outputs

Li C.K., Lu X., Wong M.C., Chan C.L., Zhu N. and Yam V.W.W., Molecular design of luminescence ion probes for various cations based on weak gold(I)...gold(I) interactions in dinuclear gold(I) complexes, Inorganic Chemistry. 2004, 43(23): 7421-7430.

Researcher : Chan CY

List of Research Outputs

Chan C.Y., Garcia J.M., Altmeyer R. and Chu I.K., Mapping of N-Glycosylation sites of spike protein S in severe acute respiratory syndrome virus using tandem mass spectrometry, Poster Presentation in 12th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, April 23, 2005. Hong Kong, Poster No.: AE-20.

Wang X., Wong L.H., Hu L., Chan C.Y., Su Z. and Chen G., Improving the accuracy of density-functional theory calculation: the statistical correction approach, Journal of Physical Chemistry A. 2004, 108(40): 8514-8525.

Researcher : Chan GKY

Project Title:	Electrochmeical oxidation of glucose
Investigator(s):	Chan GKY
Department:	Chemistry
Source(s) of Funding:	Outstanding RGC Projects
Start Date:	09/1998

Abstract:

The electrochemical oxidation of glucose on some inorganic electrodes will be studied. These electrodes appeared to have better activities than others reported in the literature. Investigations are planned to identify the oxidation products and hence the mechanism of the glucose oxidation process. Furthermore kinetics studies will be made on well characterized surfaces so that the effects of surface morphology and composition on catalytic activity can be determined. The results of these studies will help in the design of better catalytic electrodes for glucose oxidation and will be used to help in the development of a glucose sensor. The applications of these electrodes as glucose sensors will be assessed. Tests will be made for determination of glucose concentration in serum. Anti-fouling, anti-interference, linearity, and selectivity of a glucose sensor using the new catalyst will be evaluated.

Project Title:	Fuel cell research towards a clean environment
Investigator(s):	Chan GKY, Che CM
Department:	Chemistry
Source(s) of Funding:	The University of Hong Kong Foundation Seed Grant
Start Date:	03/2001

Abstract:

To accelerate and broaden existing fuel cell research, to foser external links and collaborations.

Project Title:	Mixed metal nanoparticles in fuel cell electrode reactions
Investigator(s):	Chan GKY
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	10/2001

Abstract:

To prepare and characterize mixed metal nanoparticles on HOPG or porous carbon electrodes; to study methanol oxidation on Pt-Ru, Pt-Ru/WO3 or Pt-Sn; to study morphology and structure of Pt-Ru nanoparticles with molecular dynamics simulations; to study adsorption and affinity of methanol and carbon monoxide on Pt-Ru nanoparticles with molecular dynamics simulations.

Project Title:	Precious metals recovery from industrial effluents
Investigator(s):	Chan GKY, Fang HHP, Lee W.
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	10/2002

Abstract:

Bench-top experiments are proposed to assess the feasibilities of several innovative technologies to recover precious metal ions in industrial effluents. The focus will be on inter-phase extraction, adsorption by bacteria secreted extracellular polymeric substrate, microemulsion and ion-exchange adsorption. Solubilities, partition coeficients, and recovery efficiencies will be quantified with the help of chemical and instrucmental analyses.

Project Title:	Controlled macroporous and mesoporous structures for gas-diffusion, gas-evolving, and fuel-cell electrodes
Investigator(s):	Chan GKY
Department:	Chemistry
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	08/2003

Abstract:

To synthesize and explore conducting materials with controlled nanostructures, macrostructures, and chemical composition for several electrochemical applications and their optimum performance.

Project Title:	Controlled macroporous and mesoporous structures for gas-diffusion, gas-evolving, and fuel-cell electrodes
Investigator(s):	Chan GKY
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	08/2003

Abstract:

To synthesize and explore conducting materials with controlled nanostructures, macrostructures, and chemical composition for several electrochemical applications and their optimum performance.

Project Title:	Nanostructured and functional electrode materials for electrolytic generation of ozone
Investigator(s):	Chan GKY
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004

Abstract:

To study the effects of chemical composition, level of doping, and nanostructure of doped tin dioxide electrode on the electrolytic generation of ozone.

Project Title:	Adsorption and Transport of Small Molecules and Ions in Silic Nanopores
Investigator(s):	Chan GKY
Department:	Chemistry
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2004

Abstract:

Refer to hard copy

List of Research Outputs

Chan G.K.Y., Electrolytes in nanopores: molecular simulations and related applications, Abstract of Pacific Rim Conference on Nanosciences, :Electrolytes in Nanopores: Molecular Simulations and Related Applications", Broome, Australia, Sept 7-11, 2004 . 2004.

Chen J. and Chan G.K.Y., Size-dependent mobility of platinum cluster on a graphite surface, Molecular Simulation. 2005, 31: 527-533.

Chui Y.H. and Chan G.K.Y., Distribution of platinum and cobalt atoms in a bimetallic nanoparticle, Chemical Physics Letters. 2005, 408: 49-53.

Chui Y.H. and Chan G.K.Y., Structures and energetics of platinum - cobalt bimetallic clusters, Molecular Simulation. 2004, 30(10): 679-690.

Ding J., Chan G.K.Y., Ren J. and Xiao F.S., Platinum and platinum-ruthenium nanoparticles supported on ordered mesoporous carbon and their electrocatalytic performance for fuel cell reactions, Electrochimica Acta. 2005, 50: 3131-3141.

Henderson D., Trokhymchuk A., Woodcock L.V. and Chan G.K.Y., Simulation and approximate formulae for the radial distribution functions of highly asymmetric hard sphere mixtures, Molecular Physics. 2005, 103: 667-674.

Huang G., Chan G.K.Y. and Fang H.H.P., Microbiologically induced corrosion of 70Cu-30Ni Alloy in Anaerobic Seawater, Journal of the Electrochemical Society. 2004, 151(7): 1-6.

Liu J., Wang H., Cheng S. and Chan G.K.Y., Nafion-polyfurfuryl alcohol nanocomposite membranes for direct methanol fuel cells, Journal of Membrane Science . 2005, 246: 95-101.

Tang Y.W., Chan G.K.Y. and Szalai I., Sturctural and transport properties of an SPC/E electrolyte in a nanopore, Journal of Physical Chemistry B. 2004, 108: 18204-18213.

Zhang X., Tsang K.Y. and Chan G.K.Y., Electrocatalytic properties of supported platinum-cobalt nanoparticles with uniform and controlled composition, Journal of Electroanalytical Chemistry. 2004, 573: 1-9.

Zhang X., Zhang F. and Chan G.K.Y., Synthesis and characterization of amino-functionalized mesostructured cellular foams with large mesopores using microemulsion templating, Scripta Materialia. 2004, 51: 343-347.

Zhang X., Zhang F. and Chan G.K.Y., The synthesis of large mesopores alumina by microemulsion templating, their characterization and properties as catalyst support, Materials Letters. 2004, 58: 2872-2877.

Researcher : Chan HY

List of Research Outputs

Chan H.Y., Wong M.C. and Yam V.W.W., Effect of Molecular Environmental Changes on the Aggregation and Photophysical Behavior of Novel Platinum(II) Alkynyl Complexes, The XX IUPAC Symposium on Photochemistry, Granada, Spain (Poster presented by Mr. Kenneth Hoi-Yiu Chan). 2004.

Chan H.Y., Wong M.C. and Yam V.W.W., Effect of molecular environmental changes on the aggregation and photophysical behavior of novel platinum(II) alkynyl complexes, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Mr. Kenneth Hoi Yiu Chan). 2004, P-4.

Wong M.C., Chan H.Y., Yu C. and Yam V.W.W., Photophysical and aggregation studies of luminescent organoplatinum(II) terpyridyl complexes, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Dr Keith Man Chun Wong). 2004, 0-8.

Yu C., Wong M.C., Chan H.Y. and Yam V.W.W., Polymer-induced self-assembly of alkynylplatinum(II) terpyridyl complexes via metal...metal/p...pinteractions, Angewandte Chemie International Edition. 2005, 44: 791-794.

Researcher : Chan HY

List of Research Outputs

Researcher : Chan JSC

List of Research Outputs

Kwok C.C., Ngai H.M.Y., Chan J.S.C., Sham I.H.T., Che C.M. and Zhu N., [(O^N^N)PtX] Complexes as a new class of light-emitting materials for electrophosphorescent devices, Inorganic Chemistry. 2005, 44: 4442-4444.

Researcher : Chan KY

List of Research Outputs

Sun H., Chan K.Y. and Fung Y.S., Integrating MEKC with sampling and pre-treatment for gaseous and particulate carbonyl determination, Abstract of 5^th Asia-Pacific International Symposium on Microscale Separation and Analysis (APCE2004), Dec 5-8, 2004, Seoul, South Korea. 2004, 024: 44.

Sun H., Chan K.Y. and Fung Y.S., Integrating MEKC with sampling and pre-treatment for gaseous and particulate carbonyl determination, Invited lecture at Plenary Session of the 5th Asia-Pacific International Symposium on Microscale Separation and Analysis (APCE2004), Seoul, South Korea, Dec 5-8 . 2004.

Researcher : Chan MCW

List of Research Outputs

Tam K.H., Pui Y.L., Zhu N., Chiu P. and Chan M.C.W., Studies of zirconium(IV) polyolefin catalysts bearing tridentate pyridine-2,6-bis(phenolate) auxiliaries with different donor groups, The 229^th National Meeting of the American Chemical Society, San Diego, USA, March 13-17, 2005.

Researcher : Chan PWH

Project Title:	Synthesis and applications of transition metal-nitrogen multiple bonded complexes in carbon-nitrogen bond formation reactions
Investigator(s):	Chan PWH, Che CM
Department:	Chemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To develop the chemistry of highly reactive metal-nitrogen multiple bonded complexes.

List of Research Outputs

He L., Chan P.W.H., Tsui W.M., Yu W.Y. and Che C.M., Ruthenium(II) porphyrin-catalyzed amidation of aromatic heterocycles , Organic Letters. 2004, 6: 2405-2408.

Vellaisamy A.L.R., Zhi Y.G., Xu Z., Yu S., Chan P.W.H. and Che C.M., Functionalized arylacetylene oligomers for organic thin-film transistors (OTFTs), Advanced Materials. 2005, 17: 1258-1261.

Zhang J., Liang J., Sun X., Zhou H., Zhu N., Zhou Z.Y., Chan P.W.H. and Che C.M., Chiral osmium complexes with sterically bulky schiff-base lignads. Crystal structures of Os(IV) derivatives and the reactivity and catalytic cyclopropanation of alkenes with EDA, Inorganic Chemistry. 2005, 44: 3942-3954.

Zhou C., Yu W.Y., Chan P.W.H. and Che C.M., Ruthenium porphyrin catalyzed tandem sulfonium/ammonium ylide formation and [2,3] - sigmatropic rearrangement. A concise synthesis of (±)-platynecine, Journal of Organic Chemistry. 2004, 69(21): 7072-7082.

Researcher : Chan PY

List of Research Outputs

Chan P.Y., Ong S.Y., But Y.S. and Phillips D.L., Time-resolved resonance Raman and density functional theory investigation of the 4-biphenylnitrene dimerization reaction, Journal of Raman Spectroscopy. 2004, 35: 887-894.

Chan P.Y., Kwok W.M., Lam S.K., Chiu P. and Phillips D.L., Time-resolved resonance raman observation of the 2-fluorenylnitrenium ion reaction with guanosine to form a C8 intermediate, Journal of the American Chemical Society. 2005, 127: 8246-8247.

Chan P.Y., Zhu P. and Phillips D.L., Transient resonance raman and density functional theory study of the 7-bromo-2-fluorenylnitrenium cation, Research on Chemical Intermediates. 2005, 31(1-3): 73-84.

Kwok W.M., Chan P.Y. and Phillips D.L., Direct observation of the 2-fluoenylnitrene and 4-methoxyphenylnitrene reactions with water using picosecond kerr-gated time-resolved resonance raman spectroscopy, Journal of Physical Chemistry B. 2004, 108: 19068-19075.

Kwok W.M., Chan P.Y. and Phillips D.L., Direct observation of the 4-Methoxyphenylnitrene intersystem crossing from S₁ to T₁ using picosecond kerr-gated time-resolved resonance raman spectroscopy, Journal of Physical Chemistry A. 2005, 109(10): 2394-2400.

Researcher : Chan WK

Project Title:	Synthesis of functional polymers by atom transfer radical polymerization
Investigator(s):	Chan WK
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2001

Abstract:

To design and synthesize a series of monomeric metal complexes for atom transfer radical polymerization (ATRP); to develop new experimental procedure for the synthesis of homopolymers and block copolymers by ATRP; to study the effect of monomer structure, solvent effect, counter anion, and reaction condition to the properties of the resulting polymers; to characterize the physical and morphological properites of the ploymers by different spectroscopic and microscopic techniques.

Project Title:	Hyperbranched polymeric metal complexes as novel nanomaterials
Investigator(s):	Chan WK, Djurisic A
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2002

Abstract:

The study attempts to design and synthesize different AB2 typed functional metal complexes and to synthesize a series of hyperbranched polymeric metal complexes based on these monomers; to investigate the effect of reaction condition to the branching ratio and molecular weight of polymers; to deposit the polymers on different substrates and to fabricate simple optoelectronic devices from these substrates; and to investigate the optical function and other surface properties of the polymer thin films by ellipsometry and other physical techniques.

Project Title:	Fabrication of photovoltaic devices by polyelectrolyte deposition
Investigator(s):	Chan WK, Djurisic A
Department:	Chemistry
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	08/2003

Abstract:

To prepare a series of ionic polymers that can function as photosensitizers and charge transport materials, and can be fabricated to multilayer structures by the layer-by-layer deposition process; to modify the device structures by using different combination of sensitizers, n- and p-type charge carriers, and mixed layers; to study the photoconducting and photovoltaic properties of the devices fabricated using different light sources; to simulate the experimental results into theoretical models in order to understand different physical processes such as photo charge generation, exciton diffusion, and interference effect.

Project Title:	Fabrication of photovoltaic devices by polyelectrolyte deposition
Investigator(s):	Chan WK, Djurisic A
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	08/2003

Abstract:

Project Title:	Investigation of charge generation process in photoconducting polymers
Investigator(s):	Chan WK
Department:	Chemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To study the photocurrent response of some polymers that are incorporated with various photosensitizers; to simulate the experimental results by the Onsager's Theory in order to estimate the primary yield and thermalization separation distance of the thermalized hole-electron pairs.

Project Title:	Use of Transition Metal Complexes in Heterojunction Photovoltaic Devices
Investigator(s):	Chan WK, Djurisic A
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2004

Abstract:

To synthesize a series of sublimable transition metal complexes that can be processed by caccuum deposition; to fabricate photovoltaic devices with different structures using the metal complexes as photosensitizers/change carriers; to optimize the device performance by fabricating devices with different structures, using different charge transport layers, or modifying the electrode surfaces; to study the roles of these complexes in photosensitization, exciton separation, exciton diffusion, and charge transport processes.

Project Title:	Use of Transition Metal Complexes in Heterojunction Photovoltaic Devices
Investigator(s):	Chan WK
Department:	Chemistry
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

List of Research Outputs

Cai X., Cheng K.W., Oey C.C., Djurisic A., Chan W.K., Xie M.H. and Chui P.C., Porous metallic films fabricated by self-assembly of gold nanoparticles, Thin Solid Films. Amsterdam, Elsevier B.V., 2005, 491: 66-70.

Chan W.K., Man K.K.Y., Cheng K.W., Wong H.L. and Djurisic A., Fabrication of organic photovoltaic devices by the layer-by-layer polyelectrolyte deposition method, 2004 Conference on Optoelectronic and Microelectronic Materials and Devices (COMMAD 2004), The University of Queensland, Brisbane, Australia, December 8-10, 2004.

Chan W.K., Metal containing polymers for optoelectronic applications, In: (Eds Abd-El-Aziz, Carraher, Pittman, and Zeldin), Macromolecules Containing Metal and Metal-like Elements. New York, John Wiley & Sons, 2005, 5: 117-140.

Chan W.K., Wong M.K. and Che C.M., Metalloporphyrin-catalyzed diasteroselective epoxidation of allyl-substituted alkenes, The Journal of Organic Chemistry. 2005, 70: 4226-4232.

Chan W.K., Outstanding Young Researcher Award, The University of Hong Kong. 2004.

Chan W.K., Sublimable rhenium diimine complexes as photosensitizers in efficient photovoltaic devices, American Chemical Society 228th National Meeting, Philadelphia, USA, August 22-26, 2004.

Chan W.K., Man K.Y.K., Hui C.S. and Wong H.L., The use of metal containing polymers as photo-sensitizing materials, 15th International Symposium on Photophysics and Photochemistry of Coordination Compounds, Hong Kong, July 4-9, 2004.

Chan W.K., Man K.K.Y., Wong H.L., Cheng K.W., Tse C.W. and Djurisic A., The use of metal-containing polymers as sensitizers in photovoltaic cells and photodetectors, The 5th Asian Photochemistry Conference (APC-5), Taipei, Taiwan, January 5-10. 2005.

Cheng K.W., Man K.K.Y., Tse C.W., Chan W.K. and Djurisic A., Fabrication of photovoltaic devices incorporated with cadmium sulfide nanoparticles by a multilayer deposition process, Materials Research Society 2004 Fall Meeting, Boston, USA, November 28-December 2, 2004.

Cheng K.W. and Chan W.K., Morphology of rhenium complex-containing polystryene-block-poly(4-vinylpyridine) and its use as self-assembly templates for nanoparticles, Langmuir. 2005, 21: 5247-5250.

Cheung C.H., Djurisic A., Kwong C.Y., Tam H.L., Cheah K.W., Liu Z., Chan W.K., Chui P.C., Chan J. and Rakic A.D., Change of the emission spectra in organic light-emitting diodes by layer thickness modification, Applied Physics Letters. New York, American Institute of Physics, 2004, 85: 2944-2946.

Cheung C.H., Djurisic A., Kwong C.Y., Tam H.L., Cheah K.W., Liu Z., Chan W.K., Chui P.C., Chan J. and Rakic A.D., Reduced angular dependence of the emission from tris(8-hydroxyquinoline) aluminum based microcavity, Optics Communications. Amsterdam, Elsevier B.V., 2005, 248: 287-293.

Cheung C.H., Djurisic A., Leung Y.H., Wei Z., Xu S. and Chan W.K., Tris(8-hydroxyquinoline) aluminium nanowires: a simple synthesis method, Chemical Physics Letters. Amsterdam, Elsevier B.V., 2004, 394: 203-206.

Djurisic A., Kwong C.Y., Cheung C.H., Tam H.L., Cheah K.W., Liu Z., Chan W.K. and Chui P.C., Near-infrared emission from tris(8-hydroxyquinoline) aluminum based microcavity light emitting diodes, Chemical Physics Letters. Amsterdam, Elsevier B.V., 2004, 399: 446-450.

Djurisic A., Choy W.C.H., Roy V. .A. .L., Leung Y.H., Kwong C.Y., Cheah K. .W., Gundu Rao T. .K., Chan W.K., Lui H. .F. and Surya C., Photoluminescence and EPR of ZnO tetrapod nano-structures, Advanced Funct. Mater.. 2004, 14: 856-864.

Djurisic A., Choy W.C.H., Roy V.A.L., Leung Y.H., Kwong C.Y., Cheah K.W., Rao T.K.G., Chan W.K., Lui H.F. and Surya C., Photoluminescence and electron paramagnetic resonance of ZnO tetrapod structures, Advanced Functional Materials. Weinheim, WILEY-VCH Verlag GmbH & Co., 2004, 14: 856-864.

Kwong C.Y., Djurisic A., Choy W.C.H., Li D., Xie M.H., Chan W.K., Cheah K.W., Lai P.T. and Chui P.C., Efficiency and stability of different tris(8-hydroxyquinoline) aluminium (Alq₃) derivatives in OLED applications, Materials Science and Engineering B. Amsterdam, Elsevier B.V., 2005, 116: 75-81.

Kwong C.Y., Djurisic A., Chui P.C. and Chan W.K., Nanocomposite solar cells - influence of particle concentration, size and shape on the device performance, Proceedings of SPIE. Bellingham, SPIE, 2004, 5520: 176-183.

Kwong C.Y., Choy W.C.H., Djurisic A., Chui P.C., Cheng K.W. and Chan W.K., Poly(3-hexylthiophene): TiO₂ nanocomposites for solar cell applications, Nanotechnology. Bristol, IOP Publishing Limited, 2004, 15: 1156-1161.

Leung Y.H., Djurisic A., Cheung C.H., Xie M.H. and Chan W.K., Growth of N, N'-di(naphthalene-1-yl)-N, N'-diphenyl-benzidine dome structures, Journal of Applied Physics. New York, American Institute of Physics, 2005, 97: 033515:1-5.

Leung Y.H., Djurisic A., Choy W.C.H., Xie M.H., Gao J., Cheah K.W., Man K.K.Y. and Chan W.K., Synthesis and properties of ZnO multipod structures, Journal of Crystal Growth. Amsterdam, Elsevier B.V., 2005, 274: 430-437.

Leung Y.H., Kwok W.M., Djurisic A., Phillips D.L. and Chan W.K., Time-resolved study of stimulated emission in ZnO tetrapod nanowires, Nanotechnology. Bristol, IOP Publishing Limited, 2005, 16: 579-582.

Leung Y.H., Djurisic A., Gao J., Xie M.H., Wei Z., Xu S. and Chan W.K., Zinc oxide ribbon and comb structures: synthesis and optical properties, Chemical Physics Letters. Amsterdam, Elsevier B.V., 2004, 394: 452-457.

Leung Y.H., Djurisic A., Xie M.H., Kwong C.Y. and Chan W.K., ZnO nanostructures prepared from ZnO:CNT mixtures, Proceedings of SPIE. Bellingham, SPIE, 2004, 5510: 1-8.

Li C., Kwong C.Y., Djurisic A., Lai P.T., Chui P.C., Chan W.K. and Liu S.Y., Improved performance of OLEDs with ITO surface treatments, Thin Solid Films. Amsterdam, Elsevier B.V., 2005, 477: 57-62.

Li C., Djurisic A., Kwong C.Y., Lai P.T., Chan W.K. and Liu S.Y., Indium tin oxide surface treatments for improvement of organic light-emittingdiode performance, Applied Physics A: Materials Science & Processing. Berlin, Springer-Verlag, 2005, 80: 301-307.

Li D., Leung Y.H., Djurisic A., Liu Z., Xie M.H., Shi S., Xu S. and Chan W.K., Different origins of visible luminescence in ZnO nanostructures fabricated by the chemical and evaporation methods, Applied Physics Letters. New York, American Institute of Physics, 2004, 85: 1601-1603.

To C.N., Wang H., Djurisic A., Xie M.H., Chan W.K., Xie Z., Wu C. and Tong S.Y., Solvent dependence of the evolution of the surface morphology of thin asymmetric diblock copolymer films, Thin Solid Films. Amsterdam, Elsevier B.V., 2004, 467: 59-65.

Tse C.W., Cheng K.W., Chan W.K. and Djurisic A., Self-assembled monolayer formed by a rhenium complex containing hyperbranched polymer, Macromolecular Rapid Communications. WILEY-VCH Verlag GmbH & Co., 2004, 25: 1335-1339.

Tse C.W., Lam S.M.L., Man K.K.Y., Wong W.T. and Chan W.K., Synthesis and characterization of random and block copolymers with pendant rhenium diimine complexes by controlled radical polymerization, Journal of Polymer Science: Part A: Polymer Chemistry. 2005, 43: 1292-1308.

Wong H.L., Cheng K.W., Man K.Y.K., Kwong C.Y., Chan W.K. and Djurisic A., Fabrication of bulk heterojunction photovoltaic devices using sublimable rhenium diimine complexes as photosensitizers, Proceedings of SPIE. Bellingham, SPIE, 2004, 5520: 168-175.

Researcher : Chan WK

List of Research Outputs

Chan W.K., Wong M.K. and Che C.M., Metalloporphyrin-catalyzed diasteroselective epoxidation of allyl-substituted alkenes, The Journal of Organic Chemistry. 2005, 70: 4226-4232.

Chan W.K., Outstanding Young Researcher Award, The University of Hong Kong. 2004.

Chan W.K., Sublimable rhenium diimine complexes as photosensitizers in efficient photovoltaic devices, American Chemical Society 228th National Meeting, Philadelphia, USA, August 22-26, 2004.

Leung Y.H., Djurisic A., Xie M.H., Kwong C.Y. and Chan W.K., ZnO nanostructures prepared from ZnO:CNT mixtures, Proceedings of SPIE. Bellingham, SPIE, 2004, 5510: 1-8.

Researcher : Chan WS

List of Research Outputs

Chan W.S., Ma C., Kwok W.M. and Phillips D.L., Time-resolved resonance raman and density functional theory study of hydrogen-bonding effects on the triplet state of p-methoxyacetophenone, Journal of Physical Chemistry A. 2005, 109(15): 3454-3469.

Ma C., Zuo P., Kwok W.M., Chan W.S., Kan T.W., Toy P.H. and Phillips D.L., Time-resolved resonance raman study of the triplet states of p-hydroxyacetophenone and the p-hydroxyphenacyl diethyl phosphate phototrigger compound, Journal of Organic Chemistry. 2004, 69(20): 6641-6657.

Ma C., Kwok W.M., Chan W.S., Zuo P., Kan T.W., Toy P.H. and Phillips D.L., Ultrafast time-resolved study of photophysical processes involved in the photodeprotection of p-Hydroxyphenacyl caged phototrigger compounds, Journal of the American Chemical Society. 2005, 127(5): 1463-1472.

Researcher : Chan WT

Project Title:	Measurement of trace metal in water using water-soluble polymer complexation and time-resolved ICP spectrometry
Investigator(s):	Chan WT
Department:	Chemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003
Completion Date:	10/2004

Abstract:

To develop a technique for determination of trace metal in water by direct measurement of the complex of water-soluble polymer and metal ions using time-resolved inductively coupled plasma-atomic emission spectrometry (ICP-AES) and mass spectrometry (ICP-MS).

Project Title:	Development of a Novel Bottom-Viewed Inductively Coupled Plasma Atomic Emission Spectrometry
Investigator(s):	Chan WT
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2004

Abstract:

To improve the analytical performance of bottom-viewed inductively coupled plasma atomic emission spectrometry (BV-ICP); to study the characteristics of BV-ICP.

Project Title:	Development of a Novel Bottom-Viewed Inductively Coupled Plasma Atomic Emission Spectrometry
Investigator(s):	Chan WT
Department:	Chemistry
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

Project Title:	Study of cadmium mobility and accumulation in Viola baoshanenensis
Investigator(s):	Chan WT
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2005

Abstract:

refer hard copy proposal

List of Research Outputs

Cheung W.K.A. and Chan W.T., Novel setup for investigation of the plasma conditions in direct sample insertion inductively coupled plasma atomic emission spectrometry (DSI-ISP-AES), Journal of Analytical Atomic Spectrometry. 2004, 19(9): 1111-1118.

Researcher : Che CM

Project Title:	Blue light photoluminescent materials
Investigator(s):	Che CM
Department:	Chemistry
Source(s) of Funding:	Hung Hing Ying Physical Sciences Research Fund
Start Date:	02/1999

Abstract:

To design and prepare highly robust and luminous materials for fabrication of bright blue-light emitting diode (LED) devices.

Project Title:	Research and development of new materials for organic light-emitting devices (OLEDs)
Investigator(s):	Che CM, Chan MCW
Department:	Chemistry
Source(s) of Funding:	Innovation and Technology Support Programme
Start Date:	09/2001
Completion Date:	08/2004

Abstract:

To study new materials for OLED and display technology; to develop protocol for standardized measurement of photoluminescence and solid-state quantum yields for dopants to aid display industry in Hong Kong and southern China; to study production technology for established OLED materials and polymers.

Project Title:	Metal-carbon multiple bonds. From materials science to carbon-carbon bond forming reactions
Investigator(s):	Che CM
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2001
Completion Date:	08/2004

Abstract:

To compare systematically the spectroscopic and redox properties of the metal-carbon multiple bonds based on the ruthenium and osmium complexes of macrocyclic tertiary amine ligands; to examine the ligand effects on the reactivity of highly reactive mono- and bis-carbene complexes of ruthenium and osmium, particularly toward organic substrates; to examine the excited state properties and reactivities of the metal-carbon molecular wires through coordination of the unsaturated organic fragments to platinum group metals; to develop rethenium analogues of the chiral dirhodium (II,II) acetates and derivatives as a new class of catalysts for carbon-carbon bond forming reactions; to prepare and structurally characterize various chiral metal-carbene complexes as models to probe the intro- and intermolecular C-C bond forming reactions; to develop synthetic methods for the ruthenium and osmium-benzylidyne with various auxiliary ligands; to develop redox active metal-arylacetylides with multiple hydrogen bonding sites as buildng blocks for molecular materials.

Project Title:	Institute of molecular technology for drug discovery and synthesis
Investigator(s):	Che CM
Department:	Chemistry
Source(s) of Funding:	Areas of Excellence Scheme
Start Date:	11/2001

Abstract:

To pursue world-class fundamental research in Chemical Biology; to develop novel compounds for new medicine and to engender the development of local and regional pharmaceutical industries through high quality research.

Project Title:	High-valent metal complexes and their photochemical studies
Investigator(s):	Che CM
Department:	Chemistry
Source(s) of Funding:	Matching Fund for NSFC Young Researcher Award
Start Date:	01/2002

Abstract:

To study high-valent metal complexes and their photochemical studies.

Project Title:	Shanghai-Hong Kong Joint Laboratory on chemical synthesis
Investigator(s):	Che CM
Department:	Chemistry
Source(s) of Funding:	University Research Committee / Committee on Research and Conference Grants - General Award
Start Date:	05/2002

Abstract:

To conduct research activties at Shanghai-Hong Kong Joint Laboratory on chemical synthesis

Project Title:	Oxidation chemistry of ruthenium and osmium-oxo complexes. Biomimetic oxidations and photocatalysis
Investigator(s):	Che CM, Yu WY, Miskowski VM, Chang C.K.
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2002
Completion Date:	08/2005

Abstract:

The project is to expand the scope of oxidation chemistry of ruthenium and osmium-oxo complexes by designing and studying the chemistry of new metal-oxo systems with targeted physical and chemical properties. The central theme of this project is to probe the oxygen atom transfer reactions involved in biomimetic and organic oxidations through studying the thermal oxidations and photochemistry of suitably designed and well-characterized ruthenium and osmium-oxo complexes.

Project Title:	Research and development of luminescent biosensors for drug screening and environmental monitoring
Investigator(s):	Che CM, Fu J.M., Wong K.Y.
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	11/2002

Abstract:

To optimize the luminescent materials developed by Che and co-workers for optical pH, oxygen and chlorinated hydrocarbons sensing technology; to fabricate optical biosensors using the newly developed luminescent materials; to apply the newly developed fluorescent pH/oxygen biosensors for cell viability assay, drug screening and monitoring of environmental pollutants.

Project Title:	Research and development of new phosphors for white LED
Investigator(s):	Che CM, Lai PT, Lui P.S., Cheng K.K.H.
Department:	Chemistry
Source(s) of Funding:	Teaching Company Scheme
Start Date:	07/2003
Completion Date:	06/2005

Abstract:

To identify the potential compounds as phosphors; to confirm appropriate chemical composition; to identify and develop the preparation procedures; to characterize samples; to deliver LEDs with high conversion efficiency, good color rendering and color stability; to meet the commercial value in terms of ease of processing and low manufacturing cost.

Project Title:	Development of green oxidation technology for water treatment
Investigator(s):	Che CM
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	08/2003

Abstract:

To develop efficient and cost-effective water treatment technologies based on catalytic organic oxidation using hydrogen peroxide.

Project Title:	Novel photoluminescent, sensory and photocatalytic materials derived from closed-shell metal ions and pi-conjugated organics: impact of weak intermolecular interactions and metal-functionalization upon photophysical and photochemical properties
Investigator(s):	Che CM, Lai SW
Department:	Chemistry
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	09/2003

Abstract:

Refer to hard copy

Project Title:	Novel photoluminescent, sensory and photocatalytic materials derived from closed-shell metal ions and pi-conjugated organics: impact of weak intermolecular interactions and metal-functionalization upon photophysical and photochemical properties
Investigator(s):	Che CM, Lai SW
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2003

Abstract:

Refer to hard copy

Project Title:	Organic optoelectronic: white light and full color organic light-emitting devices (OLEDs) fabrication
Investigator(s):	Che CM, Yu SC,
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	09/2003
Completion Date:	03/2005

Abstract:

To develop long-lived red-(R), green-(G) and blue-light (B) organic light-emitting devices for use in color display technology; to desgn a new charge transporting material to enhance the performance of the device up to manufacturing standard; to improve established light-emitting materials for use in OLED production.

Project Title:	Functional nanomaterials research
Investigator(s):	Che CM, Chan MCW
Department:	Chemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To develop new nanostructured and nanocomposite materials, based on the existing research expertise in synthetic chemistry, semiconductors, and ongoing collaborations with Chinese Academy of Sciences; to identify practical applications for newly prepared and patentable nanomaterials, such as catalysts for green chemistry and nanodevices for organic optoelectronics; to enable HKU to develop into a leading institution in nanosciences.

Project Title:	Metal-nitrogen multiple bonded complexes. Synthesis and applications in carbon-nitrogen bond formation reactions
Investigator(s):	Che CM, Tong SM, Chan PWH
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2004

Abstract:

To probe the mechanism of H atom abstraction and subsequent C-N bond formation by highly reactive metal-imido complexes; to develop non-porphyrin ruthenium catalysts including metal-metal bonded diruthenium systems for amidation of C-H bonds by the "PhI(OA)₂ + RNH₂ protocol; to prepare new classes of ruthenium and osmium-imido complexes other than those bearing tosylimido ligands; to explore and develop Fe catalysts containing strongly chelating polypyridine ligand systems for amidation of organic compounds; to study systematically the ruthenium-catalyzed amidation of C(sp²)-H bonds of aromatic hydrocarbons and develop its application in organic synthesis; to investigate systematically the proton-coupled electron transfer reactions of Ru-NH₂R complexes by electrochemical means.

Project Title:	Functionalized phosphorescent metal-organic materials for biomedical, photocatalytic and organic optoelectronic applications
Investigator(s):	Che CM, Lai SW, Fu W.F., Yan W.P.
Department:	Chemistry
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2005

Abstract:

To develop new classes of water-soluble phosphorescent metal-organic compounds and polymer derivatives, including those appended with polysaccharide groups, for practical applications in luminescent signaling and biomedical sciences; to develop robust polymer/matrix-supported copper(I) and platinum(II) photocatalysts for light-induced C-H bond activation and atom transfer radical addition polymerization reactions; to study the effect of π-conjugation between transition metal ions and carbon-rich organic materials upon their spectroscopic and excited-states characteristics; to develop new families of phosphorescent platinum(II) dendritic materials exhibiting tunable emission energies for organic optoelectronic applications; to prepare multinuclear Pt(II)-Ru(II) complexes which exhibit low-energy Ru(II)-to-Pt(II) and ligand-to-Pt(II) charge-transfer excited states and to study the electro-optical properties of these heterometallic compounds.

Project Title:	Photoluminescent properties and applications of luminescent d8 and d10 metal complexes with metal-metal interactions
Investigator(s):	Che CM, Yersin H.
Department:	Chemistry
Source(s) of Funding:	Germany/Hong Kong Joint Research Scheme
Start Date:	01/2005

Abstract:

To exploit the photoluminescence, determined by weak meatllophilic interactions between metal ions with d8 or d10 electronic configuration, weak ligand-ligand interactions in phosphorescent organoplatinum(II) and organogold(I) complexes and intermolecular metal-ligand interactions of d8 and d10 metal species; to elucidate the electronic origin of the emission by spectroscopic methods; to apply the effects of weak interactions upon the emissive characteristics of phosphorescent metal-organic materials to the development of new operating principles for luminescent molecular sensors and nanodevices; to synthesize phosphorescent materials with potential applications in optoelectronics of OLEDs.

Project Title:	Metal-nitrogen multiple bonded complexes. Synthesis and applications in carbon-nitrogen bond formation reactions
Investigator(s):	Che CM
Department:	Chemistry
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

Project Title:	Site-selective Modification of Proteins Catalyzed by Water-Soluble Transition Metal Complexes
Investigator(s):	Che CM
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2005

Abstract:

Objectives and significance of the research proposal to be undertakenSite-selective modification of proteins in aqueous medium is of significant importance in protein research and materials science, as it provides an indispensable tool for the studies of protein-protein and protein-drug interactions as well as the synthesis of novel nanoparticle-protein conjugates. Despite the great advancement of chemical synthesis in the last century, there is only a handful of synthetic methods that can be applied on the modifications of proteins (as most of the reactions are not compatible with aqueous medium). In this connection, there is a growing need for developing new reactions that can selectively modify biologically important biomolecules in aqueous medium. Transition metal catalysts are of particular interest in organic synthesis as their reactivities and selectivities can be fine-tuned by judicious choice of metal ions and structurally diverse ligands. Recently, some new transition metal-catalyzed atom/group transfer reactions have been developed for modification of peptide backbone in aqueous medium. However, only a few examples have been utilized for protein modification. We envision that to develop new reactions that can modify biomolecules in a selective manner, it is important to introduce structural motifs to the auxiliary ligands of metal-based catalysts for molecular recognition of the biomolecular targets.Over the years, we have extensively investigated metalloporphyrin-catalyzed atom/group transfer reactions. By virtue of the structural diversity of the macrocyclic ligand, steric and electronic properties of metalloporphyrin catalysts can be fine-tuned for stereo- and enantioselective reactions. We envisage that metalloporphyrins would have tremendous potential to be the future catalysts of choice for site-selective modification of biomolecules. Recently, we have developed two water-soluble ruthenium porphyrin catalysts by attaching hydrophilic groups such as glycan and polyethylene glycol (PEG) at the peripheral phenyl rings of porphyrin ligands for catalytic carbenoid reaction in aqueous medium. Preliminary results have shown that the ruthenium glycosylated porphyrin catalyst was effective for site-selective cyclopropanation of styrene-conjugated proteins including ubiquitin as confirmed by matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometric analysis. To our knowledge, this is the first example in which metalloporphyrins could be used to catalyze site-selective bioconjugation reactions. These modified-biomolecules would be valuable tools for proteomic and medicinal studies as well as materials science. We foresee that the application of transition metal catalysts on biomolecule modification will be the upcoming frontier area of chemical research in this century. With our existing research capability and the promising findings, we aim to (1) extend the scope of the water-soluble metalloporphyrin catalysis for site-selective protein modification research, (2) explore other carbeniod transfer reactions, and (3) apply the newly developed carbenoid transfer reactions for the conjugation of small molecules to biologically important biomolecules.

Project Title:	Strategic Theme on Drug Discovery and Synthesis
Investigator(s):	Che CM, Man RYK, Lau ASY, Li Y, Chen G
Department:	Chemistry
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	05/2005

Abstract:

To enhance collaborative interdisciplinary research between Science and Medicines with objectives to develop new drug leads and/or innovative research in biomedical sciences. To establish HKU as a leading centre in synergistic, interdisciplinary research on drug discovery and synthesis.

List of Research Outputs

Chan W.K., Wong M.K. and Che C.M., Metalloporphyrin-catalyzed diasteroselective epoxidation of allyl-substituted alkenes, The Journal of Organic Chemistry. 2005, 70: 4226-4232.

Chang R.C.C., Yu M.S., Leung S.K.Y., Lai S.W., Che C.M., Zee S.S.Y., So K.F. and Yuen W.H., Neuroprotective effects of anti-aging Chinese Medicine Lycium barbarum against b-amyloid peptide neurotoxicity. (Best Poster Prize in Poster Session 2), International Congress on Complementary and Alternative Medicines (ICCAM) 2005, 26-28 February 2005, Singapore. 2005, 145.

Che C.M., Bioinspired organic catalysis in the Sacconi Foundation Fall Seminar 2004, Invited Lecture for Visiting Scientist of National Research Council of Italy, September 15-25. 2004.

Che C.M., Bioinspired organic catalysis, Invited Speaker at the First Chemistry Week of Changchun, held in Changchun, China, August 9. 2004.

Che C.M., Bioinspired organic catalysis, Invited Speaker at the International Symposium on Chemicals and Pharmaceuticals, held in Guangzhou, China, December 16-18. 2004.

Che C.M., Editorial Board Member, Trends in Inorganic Chemistry, 2005-present. 2005.

Che C.M., Functional molecular materials. From nanomedicine to field-effect transistors, Plenary Speaker at 第一屆納米與生物交流科學研討會 - 青島 held on May 4-7,2005 in Qingdao, China. 2005.

Che C.M., Luminescent platinum(II) complexes with cyclometalated and aromatic diimine ligands: Photophysical studies and applications, Invited Lecture for Visiting Scientist of National Research Council of Italy, September 15-25. 2004.

Che C.M., Luminescent platinum(II) materials. Spectroscopic charaterization of metal-metal-to-ligand and ligand-to-ligand charge transfer excited states and sensory materials applications, Invited Speaker [a 35-minute lecture] at the 299^th American Chemical Society National Meeting, Symposium on Frontiers in Inorganic Spectroscopy and Photochemistry held at San Diego, US, March 13-17. 2005.

Che C.M., Phosphorescent metal-organic compunds. From electron transfer reactions in biological systems to new molecular materials for organic optoelectronics, Invited Lecture for Visiting Scientist of National Research Council of Italy, September 15-25. 2004.

Che C.M. and Lau T.C., Ruthenium and osmium: High oxidation states, In: Volume Editers: E.C. Constable and J.R. Dilworth, Comprehensive Coordinaton Chemistry II. Amsterdam, Elsevier Perganron, 2004, 5: 733-847.

Che C.M., Ruthenium porphyrin catalysts for organic synthesis, Invited Speaker at the Third International Conference on Porphyrins and Phthalocyanines, held in New Orleans, USA, July 11-16. 2004.

Che C.M., Ruthenium prophyrin catalysis for organic synthesis, Plenary Speaker at the International Symposium on Catalysis and Fine Chemicals 2004 (C&FC 2004), held at The Hong Kong Polytechnic University, December 12-15. 2004.

Che C.M., Structural and spectroscopic evidence for weak metal-metal interactions and metal-substrate exciplex formation, Invited Lecture for Visiting Scientist of National Research Council of Italy, September 15-25. 2004.

Che C.M., Structural and spectroscopic evidence for weak metal-metal interactions and metal-substrate exciplex formation, Plenary Lecture at the 15^th International Symposium on Photochemistry and Photophysics of Coordination Compunds (ISPPCC), held at The University of Hong Kong, July 4-9, 2004. 2004.

Che C.M., Visiting Scientist Award of National Research Council of Italy, Sacconi Foundation Fall Seminar, September 15-25, 2004. 2004.

Chen J. and Che C.M., A practical and mild method for the highly selective conversion of terminal alkenes into aldehydes through epoxidation-isomerization with ruthenium(IV)-porphyrin catalysts, Angewandte Chemie International Edition. 2004, 43: 4950-4954.

Cheung W.H., Yip W.P., Yu W.Y. and Che C.M., Oxidation of Ansioles to p-Benzoquinones Monoketals catalyzed by a Ruthenium complex of 1,4,7-Trimethyl-1, 4, 7-TriazacyclononaNe with tert-Buty1 Hydroperoxide, Canadian Jouranl of Chemistry. 2005, 83(6-7): 521-536.

Choi K.W.M., Yu W.Y. and Che C.M., Ruthenium-catalyzed stereoselective intramolecular carbenoid C-H insertion for !b- and !g-lactam formations by decomposition of a-diazoacetamides, Organic Letters. 2005, 7: 1081-1084.

Chui S.Y., Ng F.Y. and Che C.M., Structure determination of homoleptic Au^I, Ag^I, and Cu^I Aryl/Alkylethynyl coordination polymers by s-ray powder diffraction, Chemistry - A European Journal. 2005, 11: 1739-1749.

He L., Chan P.W.H., Tsui W.M., Yu W.Y. and Che C.M., Ruthenium(II) porphyrin-catalyzed amidation of aromatic heterocycles , Organic Letters. 2004, 6: 2405-2408.

Huang J.S., Leung K.Y., Zhou Z.Y., Zhu N. and Che C.M., Tuning the Reactivity of Dioxoruthenium(VI) Porphyrins toward anArylimine by Altering Porphyrin Substituents, Inorganic Chemistry. 2005, 44: 3780-3788.

Kwok C.C., Yu S.C., Sham I.H.T. and Che C.M., Self-aggregated phosphorescent platinum(II) polymeric material from modified poly(4-vinylpyridine), Chemical Communications. 2004, 2512-2513.

Kwok C.C., Yu S.C., Sham I.H.T. and Che C.M., Self-assembled zinc(II) Schiff base polymers for applications in polymer light-emitting devices, Chemical Communications. 2004, 2758-2759.

Kwok C.C., Ngai H.M.Y., Chan J.S.C., Sham I.H.T., Che C.M. and Zhu N., [(O^N^N)PtX] Complexes as a new class of light-emitting materials for electrophosphorescent devices, Inorganic Chemistry. 2005, 44: 4442-4444.

Lai S.W., Hou Y., Che C.M., Pang H.L., Wong K.Y., Chang C.K. and Zhu N., Electronic Spectroscopy, Photophysical Properties, and Emission Quenching Studies of an Oxidatively Robust Perfluorinated Platinum Porphyrin, XX IUPAC Symposium on Photochemistry, Granada, Spain, 17-22 July. 2004.

Lai S.W., Hou Y., Che C.M., Peng H.L., Wong K.Y., Chang C.K. and Zhu N., Electronic spectroscopy, photophysical properties, and emission quenching studies of an oxidatively robust perfluorinated platinum porphyrin, 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), The University of Hong Kong, Hong Kong, P. R. China, 4-9 July. 2004.

Lai S.W. and Che C.M., Luminescent cyclometalated diimine platinum(II) complexes: Photophysical studies and applications, Topics in Current Chemistry. 2004, 241: 27-63.

Li Y., Huang J.S., Xu G.B., Zhu N., Zhou Z.Y., Che C.M. and Wong K.Y., Spectral, structural, and electrochemical properties of ruthenium porphyrin diaryl and aryl(alkoxycarbonyl) carbene complexes: influence of carbene substituents, porphyrin substituents, and trans-axial ligands, Chemistry A European Journal. 2004, 10: 3486-3502.

Li Z.K., Li Y., Lei L., Che C.M. and Zhou X.G., Synthesis, structure and catalytic properties of Re(I)-NOBIN Schiff base complex, Inorganic Chemistry Communications. 2005, 8: 307-309.

Lin Y., Lai S.W., Che C.M., Fu W., Zhou Z.Y. and Zhu N., Structural variations and spectroscopic properties of luminescent mono-and multinuclear silver(I) and copper(I) complexes bearing phosphine and cyanide ligands, Inorganic Chemistry. 2005, 44: 1511-1524.

Liu Y., Wong K.W., Ko C.B., Wong M.K. and Che C.M., Synthesis and cytotoxicity studies of artemisinin derivatives containing lipophilic alkyl carbon chains, Organic Letters. 2005, 7: 1561-1564.

Liu Y.J., Xiong R.G., You X.Z. and Che C.M., One-dimensional Europium(III) coordination polymer based on 3-pyridylacrylic acid, Zeitschrift Fur Anorganische Und Allgemeine Chemie. 2004, 630(15): 2761-2764.

Luk J.M.C., Lam C.T., Lam B.H., Siu A., Che C.M. and Fan S.T., Dyregulation of chaperone proteins Hsp27, Hsp70 and Grp78 in hepatocellular carcinoma (Abstract), The 3rd HUPO Annual World Congress, Beijing, China, 25-27 October . 2004.

Luk J.M.C., Lam C.T., Lam B.H., Siu A., Che C.M. and Fan S.T., Dysregulation of chaperone proteins Hsp27, Hsp70 and Grp78 in hepatocellular carcinoma, Molecular and Cellular Proteomics. 2004, 3(10): S114, 8.19.

Mao Z., Huang J.S., Che C.M., Zhu N., Leung K.Y. and Zhou Z.Y., Unexpected reactivities of Cu₂(diphosphine)₂ complexes in alcohol: isolation, x-ray crystal structure, and photoluminescent properties of a remarkably stable [Cu₃(diphosphine)₃(m₃ - H)]²⁺ hydride complex, Journal of the American Chemical Society. 2005, 127(13): 4562-4563.

Qi J.Y., Li Y.M., Zhou Z.Y., Che C.M., Yeung C.H. and Chan A.S.C., Novel manganese complex as an efficient catalyst for the isobutyraldehyde-mediated epoxidation of cyclic alkenes with dioxygen, Advanced Synthesis & Catalysis. 2005, 347: 45-49.

Ren Y., Li W., Liu Q., Yu W.Y., Sun R.W.Y., Che C.M. and Tam P.K.H., Gold (III) porphyrines: a novel chemotherapeutic agent for human neuroblastoma, 51st Annual International Congress of British Association of Paediatric Surgeons, Oxford, U.K. 27-30 July. 2004.

Siu K.M.P., Ma D.L. and Che C.M., Luminescent cyclometalated platinum(II) complexes with amino acid ligands for protein binding, Chemical Communications. 2005, 1025-1027.

Sun R.W.Y., Yu W.Y., Sun H. and Che C.M., In vitro inhibition of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase by gold(III) porphyrins, ChemBioChem. 2004, 5(9): 1293-1298.

Vellaisamy A.L.R., Zhi Y.G., Xu Z., Yu S., Chan P.W.H. and Che C.M., Functionalized arylacetylene oligomers for organic thin-film transistors (OTFTs), Advanced Materials. 2005, 17: 1258-1261.

Wang Y., He Q., Che C.M. and Chiu J., Gold porphyrin (III) 1a induced apoptosis by caspase dependent and independent mitochondrial death pathways dependent of reactive oxygen species, 96^th Annual Meeting of AACR, Anaheim, CA, April 16-20. 2005.

Wang Y., He Q., Che C.M. and Chiu J., Gold porphyrin(III) 1a induced apoptosis through caspase-dependent and -independent mitochondrial death pathways regulated by reactive oxygen species, ASBMB Annual Meeting, SD, USA, April 16-21. 2005.

Xiang H., Chan S.C., Che C.M., Lai P.T. and Chui P.C., High-efficiency electrophosphorescent organic light-emitting devices based on schiff base platinum (II) complexes, Proceedings of PSIE. Denver, 2004, 5519: 296-303.

Xiang H., Chan S.C., Wu K.Y., Che C.M. and Lai P.T., High-efficiency red electro-phosphorescence based on neutral bis(pyrrole)-diimine platinum(II) complex, Chemical Communications. 2005, 1408-1410.

Xiang H., Li C.N., Yu S.C., Che C.M., Lai P.T. and Chui P.C., Organic, Polymer and organic/inorganic hybrid light-emitting devices based on phosphorescent fluorinated platinum (II) porphyrin, Proceedings of PSIE. Denver, 2004, 5519: 218-225.

Xie J., Huang J.S., Zhu N., Zhou Z.Y. and Che C.M., Primary and secondary phosphane complexes of metalloporphyrins: isolation, spectrocscopy, and x-ray crystal structures of ruthenium and osmium porphyrins binding phenyl- or diphenylphosphane, Chemistry - A European Journal. 2005, 11: 2405-2416.

Xu S.J., Li G., Xiong S., Tong D.S.Y., Che C.M., Liu W. and Li M.F., Spectral features of LO phonon sidebands in luminescence of free excitons in GaN, The Journal of Chemical Physics. New York, American Institute of Physics, 2005, 122: 244712: 1-5.

Yang Z., Wong L.M.E., Shum Y.T., Che C.M. and Hui Y., Fluorophore-appended steroidal saponin (Dioscin and Polyphyllin D) derivatives, Organic Letters. 2005, 7: 669-672.

Ye K., Wang J., Sun H., Liu Y., Mu Z., Li F., Jiang S., Zhang J., Zhang H., Wang Y. and Che C.M., Supramolecular structures and assembly and luminescent properties of quinacridone derivatives, Journal of Physical Chemistry B. 2005, 109: 8008-8016.

Yu M.S., Leung K.Y., Lai S.W., Che C.M., Zee S.S.Y., So K.F., Yuen W.H. and Chang R.C.C., Neuroprotective effects of anti-aging oriental medicine Lycium barbarum against bamyloid peptide neurotoxicity, Experimental Gerontology. 2005, 40: 716-727.

Zhang J., Liang J., Sun X., Zhou H., Zhu N., Zhou Z.Y., Chan P.W.H. and Che C.M., Chiral osmium complexes with sterically bulky schiff-base lignads. Crystal structures of Os(IV) derivatives and the reactivity and catalytic cyclopropanation of alkenes with EDA, Inorganic Chemistry. 2005, 44: 3942-3954.

Zhang J. and Che C.M., Dichlororuthenium(IV) complex of meso-tetrakis(2,6-dichlorophenyl) porphyrin: Active and robust catalyst for highly selective oxidation of arenes, unsaturated steroids, and electron-deficient alkenes by using 2,6-dichloropyridine N-oxide, Chemistry - A European Journal. 2005, 11: 3899-3914.

Zhou C., Yu W.Y., Chan P.W.H. and Che C.M., Ruthenium porphyrin catalyzed tandem sulfonium/ammonium ylide formation and [2,3] - sigmatropic rearrangement. A concise synthesis of (±)-platynecine, Journal of Organic Chemistry. 2004, 69(21): 7072-7082.

Researcher : Chen F

List of Research Outputs

Chen F., Zhu N. and Yang D., g⁴ - Aminoxy peptides as new peptidomimetic foldamers, Journal of the American Chemical Society. 2004, 126: 15980-15981.

Chen F., Song K. and Yang D., g⁴-Aminoxy peptides as new peptidomimetic foldamers, The 12^th Symposium on Chemistry Postgraduate Research in Hong Kong,The City University of Hong Kong, April 23,2005.

Chen F. and Yang D., g⁴-Aminoxy peptides as new peptidomimetic foldamers, The 8^th International Symposium for Chinese Organic Chemists and the 5^th International Symposium for Chinese Inorganic Chemists,The Chinese University of Hong Kong Hong Kong, December 19-22,2004.

Researcher : Chen G

Project Title:	A first-principles method for calculating STM images of nanoscale molecular systems and its application to alkyl substituted phthalocyanines and porphyrins
Investigator(s):	Chen G
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2002

Abstract:

The objective of the project is to develop an efficient first-principles method to calculate the scanning tunneling microscopy (STM) images of nonoscale molecular systems and thus build an important tool in the reearch and development of nanotechnology.

Project Title:	Towards the first-principles simulation of open systems
Investigator(s):	Chen G, Yan Y.J.
Department:	Chemistry
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	09/2003

Abstract:

To develop a first-principles quantum dissipation theory (QOT) to simulate the optical and electric processes of real open systems; to develop and implement time-dependent density-functional theory (TDDFT) based quantum dissipation theory (TDDFT-QOT).

Project Title:	Towards the first-principles simulation of open systems
Investigator(s):	Chen G, Yan Y.J.
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2003

Abstract:

Project Title:	First-principles quantum mechanical methods as predictive tools in materials design: neural networks approach
Investigator(s):	Chen G
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2004

Abstract:

To employ Neural-Networks-based algorithms to improve greatly the accuracies of the first-principles quantum mechanical methods; to reduce the numerical errors within 1 to 2 kcal/ mol, i.e. the chemical accuracy; to combine the artificial intelligence and the first-principles quantum mechanical methods; to have profound impacts to computational chemistry and physics; to pave the way for the first-principles quantum mechanical methods to be employed as practical tools in materials design and research.

Project Title:	Theoretical Investigation and Computer Simulation of Carbon-Nanotube-Based Devices: Gigahertz Oscillators, Field Emitters and Tweezers
Investigator(s):	Chen G
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	10/2004

Abstract:

To explore potential electric and mechanical applications of CNTs; to design new types of nanomechanical devices as operative tools for manipulating atoms and molecules; to contribute to the advancements of nanoscopic science and technology.

Project Title:	Theoretical Investigation and Computer Simulation of Carbon-Nanotube-Based Devices: Gigahertz Oscillators, Field Emitters and Tweezers
Investigator(s):	Chen G
Department:	Chemistry
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

Project Title:	Efficient linear scaling methods for optical properties of nanoscale material systems
Investigator(s):	Chen G, Frauenheim T.
Department:	Chemistry
Source(s) of Funding:	Germany/Hong Kong Joint Research Scheme
Start Date:	01/2005

Abstract:

To develop linear-scaling quantum mechanical methods to simulate complex molecular systems such as nanotubes, nanowires, polymer films, surface, interfaces and biological molecules; to apply the resulting methods to examine the charge transport, optical and magnetic properties of nanotubes and nanowires and the photophysical processes in biological molecules.

Project Title:	Theoretical investigation of Zinc Oxide nanobelts and nanodevices
Investigator(s):	Chen G
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2005

Abstract:

refer hard copy proposal

List of Research Outputs

Duan X.M., Song G.L., Li Z.H., Wang X., Chen G. and Fan K.N., Accurate prediction of heat of formation by combining Hartree-Fock/density functional theory calculation with linear regression correction approach, Journal of Chemical Physics. 2004, 121(15): 7086-7095.

Duan X.M., Li Z.H., Hu H.R., Song G.L., Wong G.L., Chen G. and Fan K.N., Linear regression correction to first principle theoretical calculations - Improved descriptors and enlarged training set, Chemical Physics Letters. 2005, 409: 315-321.

Li F., Li H., Hu L., Kwan M.F., Chen G., He Q. and Sun H., Structure, assembly, and topology of the G185R mutant of the fourth transmembrane domain of divalent metal transporter, Journal of the American Chemical Society. 2005, 127(5): 1414-1423.

Wang Q., Hu T., Chen G. and Jiang Q., Bending instability of double-walled carbon nanotubes, Physical Review B. 2005, 71: 045403-1 - 045403-8.

Wang X., Wong L.H., Hu L., Chan C.Y., Su Z. and Chen G., Improving the accuracy of density-functional theory calculation: the statistical correction approach, Journal of Physical Chemistry A. 2004, 108(40): 8514-8525.

Yam C.Y., Ma C.C., Wang X. and Chen G., Electronic structure and charge distribution of potassium iodide intercalated single-walled carbon nanotubes, Applied Physics Letters. 2004, 85(19): 4484-4486.

Yan L.K., Su Z.M., Guan W., Zhang M., Chen G., Xu L. and Wang E.B., Why does disubstituted hexamolybdate with arylimido prefer to form an orthogonal derivative? Analysis of stability, bonding character, and electronic properties on molybdate derivatives by density functional theory (DFT) study, Journal of Physical Chemistry B. 2004, 108(45): 17337-17343.

Zhao Y., Zanardi P. and Chen G., Quantum entanglement and the self-trapping transition in polaronic systems, Physical Review B. 2004, 70: 195113-1 - 195113-5.

Researcher : Chen H

List of Research Outputs

Chen H. and Yang D., AgBF₄ mediated cyclization of 1,6-enynes, The 12^th Symposium on Chemistry Postrgaduate Research in Hong Kong, The City University of Hong Kong, April 23,2005.

Researcher : Chen J

List of Research Outputs

Chen J. and Che C.M., A practical and mild method for the highly selective conversion of terminal alkenes into aldehydes through epoxidation-isomerization with ruthenium(IV)-porphyrin catalysts, Angewandte Chemie International Edition. 2004, 43: 4950-4954.

Chen J. and Chan G.K.Y., Size-dependent mobility of platinum cluster on a graphite surface, Molecular Simulation. 2005, 31: 527-533.

Researcher : Chen J

List of Research Outputs

Chen J. and Chan G.K.Y., Size-dependent mobility of platinum cluster on a graphite surface, Molecular Simulation. 2005, 31: 527-533.

Researcher : Chen Y

List of Research Outputs

Ho C.Y., Chen Y., Wong M.K. and Yang D., Fluorinated chiral secondary amines as catalysts for epoxidation of olefins with oxone, The Journal of Organic Chemistry. 2005, 70: 898-906.

Researcher : Cheng CC

List of Research Outputs

Cheng C.C., Lo W.Y., Zhu N. and Yam V.W.W., Luminescent soluble polynuclear gold(I) chalcogenido aggreates-syntheses, characterization and photophysics, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Dr. Eddie Chung Chin Cheng). 2004, P-9.

Yip S.K., Cheng C.C., Yuan L., Zhu N. and Yam V.W.W., Supramolecular assembly of luminescent gold(I) alkynylcalix[4]crown-6 complexes with planar h² , h² - coordinated gold(I) centers, Angewandte Chemie International Edition. 2004, 43: 4954-4957.

Researcher : Cheng KW

List of Research Outputs

Cai X., Cheng K.W., Oey C.C., Djurisic A., Chan W.K., Xie M.H. and Chui P.C., Porous metallic films fabricated by self-assembly of gold nanoparticles, Thin Solid Films. Amsterdam, Elsevier B.V., 2005, 491: 66-70.

Chan W.K., Man K.K.Y., Cheng K.W., Wong H.L. and Djurisic A., Fabrication of organic photovoltaic devices by the layer-by-layer polyelectrolyte deposition method, 2004 Conference on Optoelectronic and Microelectronic Materials and Devices (COMMAD 2004), The University of Queensland, Brisbane, Australia, December 8-10, 2004.

Chan W.K., Man K.K.Y., Wong H.L., Cheng K.W., Tse C.W. and Djurisic A., The use of metal-containing polymers as sensitizers in photovoltaic cells and photodetectors, The 5th Asian Photochemistry Conference (APC-5), Taipei, Taiwan, January 5-10. 2005.

Cheng K.W., Man K.K.Y., Tse C.W., Chan W.K. and Djurisic A., Fabrication of photovoltaic devices incorporated with cadmium sulfide nanoparticles by a multilayer deposition process, Materials Research Society 2004 Fall Meeting, Boston, USA, November 28-December 2, 2004.

Cheng K.W. and Chan W.K., Morphology of rhenium complex-containing polystryene-block-poly(4-vinylpyridine) and its use as self-assembly templates for nanoparticles, Langmuir. 2005, 21: 5247-5250.

Kwong C.Y., Choy W.C.H., Djurisic A., Chui P.C., Cheng K.W. and Chan W.K., Poly(3-hexylthiophene): TiO₂ nanocomposites for solar cell applications, Nanotechnology. Bristol, IOP Publishing Limited, 2004, 15: 1156-1161.

Tse C.W., Cheng K.W., Chan W.K. and Djurisic A., Self-assembled monolayer formed by a rhenium complex containing hyperbranched polymer, Macromolecular Rapid Communications. WILEY-VCH Verlag GmbH & Co., 2004, 25: 1335-1339.

Wong H.L., Cheng K.W., Man K.Y.K., Kwong C.Y., Chan W.K. and Djurisic A., Fabrication of bulk heterojunction photovoltaic devices using sublimable rhenium diimine complexes as photosensitizers, Proceedings of SPIE. Bellingham, SPIE, 2004, 5520: 168-175.

Researcher : Cheng KW

List of Research Outputs

Researcher : Cheng S

List of Research Outputs

Liu J., Wang H., Cheng S. and Chan G.K.Y., Nafion-polyfurfuryl alcohol nanocomposite membranes for direct methanol fuel cells, Journal of Membrane Science . 2005, 246: 95-101.

Researcher : Cheung ASC

Project Title:	Catalytic reaction in a supersonic nozzle beam: CO₂ reforming of CH₄
Investigator(s):	Cheung ASC, Au C.T.
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	12/2002

Abstract:

This project is to study catalytic reactions in a short time sacle rather than traditionally at equilibrium. Specifically, it studies the catalytic reaction of converting carbon dioxide and methane to valuable synthesis gas with transition metal based catalyst.

Project Title:	Hyperfine structure of lanthanide oxides
Investigator(s):	Cheung ASC
Department:	Chemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003
Completion Date:	10/2004

Abstract:

To record and analyze high-resolution electronic transition spectra of lanthanide oxides.

Project Title:	Laser Jet Spectroscopy of Low-lying Electronic States of Group III-V Diatomic Molecules
Investigator(s):	Cheung ASC
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	12/2004

Abstract:

To record the electronic transition spectrum of some selected gas-phase Group III-V diatomic molecules in the visible and NIR spectral regions; to analyze the electronic transition spectrum recorded for some-selected Group III-V diatomic molecules and determine their molecular structure. Reasons for the change: the change from covering the UV. visible and NIR spectral regions of the Group III-V diatomic molecules to only the visible and NIR regions of some selected Group III-V diatomic molecules is necessary because, at the present funding level, resource is insufficient for us to tackle the whole spectral region and most of the Group III-V molecules as proposed.

Project Title:	Laser Jet Spectroscopy of Low-lying Electronic States of Group III-V Diatomic Molecules
Investigator(s):	Cheung ASC
Department:	Chemistry
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

Project Title:	Optical-optical double resonance spectroscopy of transition metal compounds
Investigator(s):	Cheung ASC
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2005

Abstract:

The objective of the proposed investigation is to study the high-lying electronic transitions of transitional metal compounds. It is proposed to combine laser vaporization/reaction free jet expansion source for producing the metal compound in gas-phase and optical-optical double resonance (OODR) spectroscopy to study electronic states near the dissociation limit. The goal of this research is to determine the vibrational and rotational, constants for electronic transitions of transition metal compounds. Supersonic expansion is a well-known technique for cooling the internal degrees of freedom of molecules far below the normal boiling point, while maintaining the molecule in gas-phase. Recently, this technique has been combined with laser vaporization/reaction source to produce high-boiling point transition metal compounds and dimers. A localized pulse heating of the metal or metallic compound by focused laser irradiation is technically superior to the extreme temperatures required to vaporize metal compounds. An intense pulse beam source of gas mixtures provides chemicals for the reaction with vaporized metal atom. The technique of laser vaporization/reaction with supersonic expansion has been proven to be successful in forming metallic compounds in gas-phase at low temperature. In OODR spectroscopy, two photons of different wavelength undergo absorption in a three-level system. Both of these photons are either from the near infrared, visible or ultra violet or each is from a different one of these spectral regions. When these two photons are arranged to pass each other in opposite directions, a spectrum with sub-Doppler resolution could be obtained. The OODR process with two photons absorption in two steps reaching for the high-lying electronic state is called cascade OODR process, which permits the study of these high-lying electronic states that are not reachable either because of symmetry characteristics from the ground state or due to limitation in photon energy with only one photon. The molecules excited are those in the specific lower level to upper levels of various electronic states, so excitation is selective for this transition or a group of transitions. Spectroscopy involving a double resonance technique in which transitions are detected through fluorescence is of advantages. This is because in the optical region the detection of fluorescence photon against a background of zero or little scattered laser light is intrinsically much more sensitive than the detection of direct absorption of laser light. The applicant has an on-going programme and long history of studying transition metal containing species in the visible and near infrared region using laser induced fluorescence techniques with an argon ion pump dye laser system. It is proposed here to combine the laser vaporization/reaction supersonic expansion technique with OODR spectroscopy to study electronic transitions of transition metal compounds. Such a combined approach should be fruitful for studying the high-energy electronic states because it solves the problem of getting the high melting point compounds in the gas-phase and performing high-resolution study. In this project, a widely tunable pulsed dye laser and narrow linewidth laser source will be used to excite the metal compound molecules and the detection is by fluorescence spectroscopy. Most of the high-lying electronic transitions of transition metal compounds are not known, once these molecules are produced in a supersonic jet, an extensive spectral search for the electronic transitions is necessary.

List of Research Outputs

Jamieson M.J. and Cheung A.S.C., Shifts in the A²å⁺-X²II band systems of ¹⁶OH, ¹⁸OH, ¹⁶OD and ¹⁸OD, Journal of Physics B: Atomic, Molecular and Optical Physics. 2005, 38: 939-947.

Leung W.H., Ma T. and Cheung A.S.C., Cavity ring down absorption spectroscopy of the B²å⁺-X²å⁺ transition of YO, Journal of Molecular Spectroscopy. 2005, 229: 108-114.

Ma T., Li L., Leung W.H., Wong M.Y. and Cheung A.S.C., Cavity ring-down laser absorption spectroscopy of yttrium and nickel monoiodides, 60th Ohio State University International Symposium on Molecular Spectroscopy, U.S.A., June 20-24. 2005, FB05.

Tam W.S., Ye J. and Cheung A.S.C., Near-infrared laser spectroscopy of NiI, Journal of Chemical Physics. 2004, 121(19): 9430-9435.

Thorne A.P., Rufus J., Yoshino K., Cheung A.S.C. and Imajo T., Erratum: the application of a VUV fourier transform spectrometer and synchrotron radiation source to measurements of absorption bands of NO [J. chem. phys. 115, 3719(2001); 116, 155(2002); 117, 10621 (2002); 119, 8373 (2003)], The Journal of Chemical Physics. 2005, 122: 179901-1 - 179901-3.

Ye J., Leung W.H. and Cheung A.S.C., Laser spectroscopy of nickel monobromide, 60th Ohio State University International Symposium on Molecular Spectroscopy, U.S.A., June 20-24. 2005, FB04.

Researcher : Cheung KK

List of Research Outputs

Chong H.F., Lam C.F., Yam V.W.W., Zhu N., Cheung K.K., Fathallah S., Costuas K. and Halet J.F., Luminescent heterometallic branched alkynyl complexes of rhenium(I) - palladium(II): potential building blocks for heterometallic metallodendrimers, Organometallics. 2004, 23(21): 4924-4933.

Guan X., Tse M.K., Yang Y., Sze K.H., Cheung K.K. and Wong K.B., Structure and dynamics of a thermophilic acylphosphatase from Pyrococcus horikoshii by NMR spectroscopy - structural basis of thermostability and enzymatic activities, Twelfth Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong, The City University of Hong Kong, 23 Apr. 2005. 43.

Lam C.F., Chong H.F., Cheung K.K. and Yam V.W.W., Luminescent rhenium(I) complexes with linear and hyperbranched alkynyl ligands, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Miss Sally Chan Fung Lam). 2004, P-30.

Sze K.H., Yang Y., Guan X., Tse M.K., Cheung K.K. and Wong K.B., Structure and dynamics of a thermophilic acylphosphatase from Pyrococcus horikoshii by NMR spectroscopy - structural basis of thermostability and enzymatic activities, XXI International Conference on Magnetic Resonance in Biologicall Systems, Hyderabad, India, 16-21 Jan, 2005. 155.

Wong M.C., Li W., Cheung K.K. and Yam V.W.W., Synthesis, photophysics, electrochemistry and metal ion-binding studies of rhenium(I) complexes with crown ether pendants:selective and specific binding properties for various metal ions, New Journal of Chemistry. 2005, 29: 165-172.

Yip S.K., Cheung K.L., Yuan L., Cheung K.K., Zhu N. and Yam V.W.W., Synthesis, luminescence and ion-binding properties of gold(I) alkynylcalix[4]crown complexes, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Mr. Sung Kong Yip). 2004, P-79.

Researcher : Cheung KK

List of Research Outputs

Researcher : Cheung KL

List of Research Outputs

Cheung K.L., Yip S.K. and Yam V.W.W., Synthesis, characterization, electrochemistry and luminescence studies of heterometallic gold(I)-rhenium(I) alkynyl complexes, Journal of Organometallic Chemistry. 2004, 689(24): 4451-4462.

Yam V.W.W., Cheung K.L., Yip S.K. and Zhu N., Synthesis, characterization, electrochemistry and luminescence studies of 9-anthrylgold(I) complexes, Photochemical and Photobiological Sciences. 2005, 4: 149-153.

Yip S.K., Cheung K.L., Yuan L., Cheung K.K., Zhu N. and Yam V.W.W., Synthesis, luminescence and ion-binding properties of gold(I) alkynylcalix[4]crown complexes, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Mr. Sung Kong Yip). 2004, P-79.

Researcher : Cheung KL

List of Research Outputs

Researcher : Cheung WKA

List of Research Outputs

Cheung W.K.A. and Chan W.T., Novel setup for investigation of the plasma conditions in direct sample insertion inductively coupled plasma atomic emission spectrometry (DSI-ISP-AES), Journal of Analytical Atomic Spectrometry. 2004, 19(9): 1111-1118.

Researcher : Chiu J

Project Title:	Regulation of [alpha]-fetoprotein gene expression in differentiating and cancer cells
Investigator(s):	Chiu J
Department:	Institute of Molecular Biology
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2002

Abstract:

The project attempts to: (1) Identify and characterize DAS-binding protein (DAP) that regulate [alpha]-fetoprotein expression; (2) Investigate the specific DNA binding activity and biological function of DAP. The biological function will be determined by using various mutant genes, DAP antisense sequence and transcription factor decoys; (3) Identify other genes that are regulated by the DAS cis-element through a computer-assisted analysis of the genomic sequences in GenBank; and (4) Investigate the expression of these candidate genes in F9 cells during differentiation, and in developing liver cells and hepatomas.

Project Title:	Action mechanisms of nano-sized silver particles (nanosilver) as therapeutic agent
Investigator(s):	Chiu J, Tam PKH, He Q, Che CM
Department:	Institute of Molecular Biology
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	09/2003

Abstract:

To determine antibacterial and anticancer effects of nanosilver; to determine differential protein expression of cells treated with nanosilver; to identify key elements of oxidative stress that involve in nanosilver-induced antibacterial activity and anticancer effect; to determine which signal pathways that mediates nanosilver-induced cell death.

Project Title:	Biochemical and proteomic analyses of arsenic carcinogenesis
Investigator(s):	Chiu J, Leung SY, He Q
Department:	Institute of Molecular Biology
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	09/2003

Abstract:

To establish and examine the processes of in vitro carcinogenesis induced by arsenic; to identify key elements of oxidative stress that involve in arsenic-induced cell transformation by biochemical and proteomic approaches; to determine which signaling pathway that mediates arsenic-induced cell transformation by proteomic approach.

Project Title:	Biochemical and proteomic analyses of arsenic carcinogenesis
Investigator(s):	Chiu J, Leung SY, He Q
Department:	Institute of Molecular Biology
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2003

Abstract:

Researcher : Chiu P

Project Title:	Studies on the tandem intramolecular metal carbene cyclization-cycloaddition and its application toward the synthesis of curcumol
Investigator(s):	Chiu P
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2001

Abstract:

To examine the effect of [alpha]-carbonyl substitutents on the intramolecular carbene cyclization- tandem cycloaddition reaction, and to determine the dependence of the diastereoselectivity on the steric hindrance and/or chelating ability of the substituents; to study the use of selected metal catalysts, achiral and chiral, to influence and direct the diastereoselectivity of this reaction; to investigate the regiochemical and stereochemical outcome of the cyclization- intramolecular cycloaddition with a tethered allenyl system.

Project Title:	Applications of copper hydride reductions to organic synthesis
Investigator(s):	Chiu P
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	07/2002

Abstract:

The project will examine substrates including alkynones and nitroalkenes, that will undergo stereoselective reductive aldol reaction to achieve new motifs in the products. Intermolecular aldol reaction will be developed to make the protocol more generally applicable to organic synthesis. Efforts will be devoted to achieve a catalytic reductive aldol reaction, which will make this reaction more economical and environmentally sound.

Project Title:	Synthetic studies and novel extensions on the tandem carbene cyclization cycloaddition reaction
Investigator(s):	Chiu P
Department:	Chemistry
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2003

Abstract:

To investigate the exploitation of the tandem carbene cyclization-cycloaddition cascade for the synthesis of the secodolastane and dolastane nuclei; to synthesize natural products of the dolastane family; to create a library of organic compounds based on the dolastane skeleton; to investigate the feasibility, reaction parameters and stereochemistry of a Diels-Alder cyclization in tandem with the traditional carbene cyclization-cycloaddition cascade.

Project Title:	Intramolecular cycloadditions of sulfonyl-activated substrates
Investigator(s):	Chiu P, Metz P.
Department:	Chemistry
Source(s) of Funding:	Germany/Hong Kong Joint Research Scheme
Start Date:	01/2004

Abstract:

To devise a synthetic route toward diazoketones which contain a vinylsulfonate as dipolarophile; to examine the reactivity and diastereoselectivity of metal catalyzed carbene cyclization-cycloaddition of these substrates; to examine the ring opening reactions of the heterocyclic products of cycloadditions; to apply these results in the enantioselective synthesis of biologically active natural products such as ferutinin and tenuferidin.

Project Title:	Novel reactions mediated by copper hydrides
Investigator(s):	Chiu P
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004
Completion Date:	01/2005

Abstract:

To investigate the use of Stryker's reagent for the catalysis of the hydrostannation of alkynes; to determine the scope and the optimized conditions for the hydrostannation reaction.

Project Title:	Synthetic Studies toward Guanacastepene A
Investigator(s):	Chiu P, Toy PH
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	08/2004

Abstract:

To study the carbene cyclization cycloaddition cascade reaction and its application to the synthesis of the BC ring system of guanacastepene A; to synthesize and characterize monomers and polymers bearing arsine residues; to evaluate the use of immobilized arsines in organic synthesis, and its application to the synthesis of guanacastepene; to use of Nazarov cyclization strategy to elaborate the BC ring system to the ABC rings of guanacastepene; to engage in studies toward the asymmetric total synthesis of guanacastepene A.

Project Title:	Synthetic Studies toward Guanacastepene A
Investigator(s):	Chiu P
Department:	Chemistry
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

Project Title:	Reactions of novel diazoketones
Investigator(s):	Chiu P
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2005

Abstract:

1. To investigate the synthesis of beta-hydroxy-α-diazoketones 2. To synthesize structurally novel beta-hydroxy-α-diazoketones 3. To explore the reactivity of beta-hydroxy-α-diazoketones, particularly as metal carbene precursors, and their applications in organic synthesis

List of Research Outputs

Chan P.Y., Kwok W.M., Lam S.K., Chiu P. and Phillips D.L., Time-resolved resonance raman observation of the 2-fluorenylnitrenium ion reaction with guanosine to form a C8 intermediate, Journal of the American Chemical Society. 2005, 127: 8246-8247.

Chiu P., A Synthetic Journey Inspired by Natural Products, The 21st Summer Seminar on Synthetic Organic Chemistry, The Synthetic Organic Chemistry Society of Japan. 2004.

Chiu P., Application of the Tandem Carbene Cyclization Cycloaddition Reaction in Total Synthesis, The 15^th International Conference On Organic Synthesis, Nagoya, Japan, August 1-6, 2004. 2004, 1L-1.

Chiu P., Novel applications of Stryker's reagent in organic synthesis, The 8^th International Symposium of Chinese Organic Chemists, The Chinese University of Hong Kong, Dec 12-19, 2004. 1L-26.

Chiu P., Organosilanes in copper-mediated conjugate reductions and reductive aldol reactions, Synthesis. G. Thieme Verlag, 2004, 2210-2215.

Chiu P. and Leung S.K., Stoichiometric and catalytic reductive aldol cyclizations of alkynediones induced by Stryker's reagent, Chemical Communications. 2004, 2004(20): 2308-2309.

Chung W.K. and Chiu P., Reductive intramolecular Henry reactions induced by Stryker's reagent, Synlett. G. Thieme Verlag, 2004, 55-58.

Chung W.K. and Chiu P., [4+3] Cycloaddition of oxyallyl cations from epoxy enol silanes, The 8^th International Symposium for Chinese Organic Chemists, The Chinese University of Hong Kong, Dec 12-19, 2004. PP-23.

Fung C.M.K. and Chiu P., Intramolecular Reductive-aldol cyclization of enedione systems catalyzed by Stryker's reagent, The 8^th International Symposium for Chinese Orgamic Chemists, The Chinese University of Hong Kong, Dec 12-19, 2004. PP-35.

Ko C.B., Wong K.W., Chiu P., Chung S.S.M., Chow L.M. and Yang B.B., Pseudolaric acid B as a new class of microtubule destabilizing agent and an effective anti-tumor compound in vivo, Abstract of 44^th Annual Meeting of The American Society for Cell Biology, Washington Convention Center, Washington, DC, U.S.A. December 4-8,2004.

Lam S.K. and Chiu P., Studies toward the synthesis of linearol, The 15^th International Conference on Organic Synthesis, Nagoya, Japan, August 1-6, 2004. 3-E-19.

Lam S.K. and Chiu P., Studies toward the synthesis of linearol, The 8^th International Symposium for Chinese Organic Chemists, The Chinese University of Hong Kong, Dec 12-19, 2004. PP-71.

Lau C.Y., He S., Chiu P. and Toy P.H., Polystyrene-supported triphenylarsine reagents and their use in Suzuki cross-coupling reactions, Journal of Combinatorial Chemistry. 2004, 6(6): 955-960.

Lau C.Y. and Chiu P., Polystyrene-supported triphenylarsine reagents and their use in Suzuki cross-coupling reactions, The 8th International Symposium of Chinese Organic Chemists, The Chinese University of Hong Kong, Dec 12-19, 2004. PP-75.

Leung L.T., Leung S.K. and Chiu P., Hydrostannation of alkynes catalyzed by Stryker's reagent, The 8^th International Symposium for Chinese Organic Chemists, The Chinese University of Hong Kong, Dec 12-19, 2004. 2004, PP-80.

Leung S.K. and Chiu P., Metal-catalyzed cyclopropanation on the 8-oxabicyclo[3.2.1]oct-6-ene template, Tetrahedron Letters. 2005, 46(15): 2709-2712.

Li S., Zhang X., Ko Y.Y. and Chiu P., Application of the rhodium-catalyzed carbene cyclization cycloaddition cascade to the synthesis of natural products, International Symposium on Catalysis and Fine Chemicals 2004(C&FC 2004) - Poster Presentation, Hong Kong Polytechnic University, Dec 12 -15. 2004, P-122.

Li S. and Chiu P., Studies toward the total synthesis of guanacastepene A, The 8^th International Symposium of Chinese Organic Chemits, The Chinese University of Hong Kong, Dec 12-19,2004. PP-85.

Tam K.H., Pui Y.L., Zhu N., Chiu P. and Chan M.C.W., Studies of zirconium(IV) polyolefin catalysts bearing tridentate pyridine-2,6-bis(phenolate) auxiliaries with different donor groups, The 229^th National Meeting of the American Chemical Society, San Diego, USA, March 13-17, 2005.

Yao G.M., Ding Y., Zuo J.P., Wang H.B., Wang Y.B., Ding B.Y., Chiu P. and Qin G.W., Dihydrochalcones from the leaves of Pieris japonica, Journal of Natural Products. AmcllmSoc, 2005, 68: 392-396.

Researcher : Choi KWM

List of Research Outputs

Choi K.W.M., Yu W.Y. and Che C.M., Ruthenium-catalyzed stereoselective intramolecular carbenoid C-H insertion for !b- and !g-lactam formations by decomposition of a-diazoacetamides, Organic Letters. 2005, 7: 1081-1084.

Researcher : Chong HF

List of Research Outputs

Chong H.F., Lam C.F., Yam V.W.W., Zhu N., Cheung K.K., Fathallah S., Costuas K. and Halet J.F., Luminescent heterometallic branched alkynyl complexes of rhenium(I) - palladium(II): potential building blocks for heterometallic metallodendrimers, Organometallics. 2004, 23(21): 4924-4933.

Chong H.F., Lam C.F., Ko C.C. and Yam V.W.W., Synthesis, characterization and luminescence studies of trinuclear rhenium-cobalt mixed-metal alkynyl complexes containing a tetrahedral Co₂C₂ cluster unit¹, Journal of Cluster Science. 2004, 15(3): 301-314.

Lam C.F., Chong H.F., Cheung K.K. and Yam V.W.W., Luminescent rhenium(I) complexes with linear and hyperbranched alkynyl ligands, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Miss Sally Chan Fung Lam). 2004, P-30.

Researcher : Chu BWK

List of Research Outputs

Chu B.W.K. and Yam V.W.W., Luminescent metal complexes as labels for biomolecules and candidates for photodynamic therapy, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Dr. Ben Wai Kin Chu). 2004, P-10.

Wong M.C., Tang W.S., Chu B.W.K., Zhu N. and Yam V.W.W., Synthesis, photophysical properties, and biomolecular labeling studies of luminescent platinum(II)-terpyridyl alkynyl complexes, Organometallics. 2004, 23(14): 3459-3465.

Researcher : Chu IK

Project Title:	Novel and automated methodologies for protein sequencing and identification
Investigator(s):	Chu IK
Department:	Chemistry
Source(s) of Funding:	Seed Funding for New Staff
Start Date:	03/2003

Abstract:

To develop novel, efficient mass spectrometric methodologies in sequencing the amino-acid residues of peptides, which will be used for protein identification.

Project Title:	Formation of molecular radical cations of oligopeptides
Investigator(s):	Chu IK, Rodriquez C.F.
Department:	Chemistry
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	08/2003

Abstract:

To determine factors that influence the radical cation formaton: (a) effect of amino acid composition, (b) effect of peptide sequence, (c) effect of metal center, (d) effect of ligand; to estimate the reduction potential of the metal complex and its gas phase acidity.

Project Title:	Formation of molecular radical cations of oligopeptides
Investigator(s):	Chu IK, Rodriquez C.F.
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	08/2003

Abstract:

Project Title:	Mapping of N-Glycosylation Sites of Selected Glycoproteins by Means of Tandem Mass Spectrometry
Investigator(s):	Chu IK
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2005

Abstract:

Protein glycosylation has been recognized as one of the most common protein post-translational modifications, especially N-linked glycosylation, which plays important roles in various virus-receptor interactions.[1] Determining the exact residues that are glycosylated is an essential part in understanding protein function. Identification and sequence information of the specific proteins expressed are highly desirable but difficult to acquire because of small sample sizes, low concentrations and the requirement of sensitive analytical techniques. The ability to identify and determine proteins in femtomole quantities is rapidly being realized with the advent in the late 1980s of electrospray (ESI) and matrix-assisted laser desorption/ionization (MALDI), ionization techniques for mass spectrometry that are sensitive and well-suited for proteins.[2] The advent of the aforementioned soft ionization techniques recognized by the 2002 Nobel Price in chemistry in which revolutionized the field of mass spectrometry by enabling the introduction of very large non-volatile biomolecules into the gas phase. These techniques are used routinely to introduce peptides and proteins into the gas phase, in the form of closed-shell protonated ions, [M + nH]n+ or species cationized on metals, followed by structure determination using tandem mass spectrometry (MS/MS). Protein MS, in combination with high-resolution separation techniques and database searching, is being applied to identify proteins via their tryptic maps and partial sequence data. However, the genetically determined sequence of the amino acids defines the structure and ultimately the function of the protein. Many important proteins are post-translationally modified, such as the spike glycoproteins from Severe Acute Respiratory Syndrome (SARS) coronavirus and Gp120 from Human Immunodeficiency Virus (HIV), an essential step rendering them functionally active; post-translational modifications are not apparent from genomics sequence or mRNA expression data. The detection of protonated peptides via ESI or MALDI-MS has been recognized as key technology in the identification of proteins and it post-translation modifications. A complete glycosylation sites mapping of glycoproteins in complexes biological sample could be difficult to acquire owing to the observed peptide ions from ESI or MALDI-MS are sequence, MS ionization and charge dependent as a result of bottom necking in complete N-Glycosylation sites identification. We ascribe the favorable formation of protonated peptides may be due to the relatively high proton affinity and ionization efficiency of particular peptides.In this proposal, we aim to (1) study the effects of sequential specific and non-specific enzymatic digestion, ionization techniques and sample purification on the protein coverage; (2) develop methodologies to confirm and screen the potential N-glycosylation sites using tandem mass spectrometry; and (3) develop an appropriate method for the extraction, enrichment, and purification of glycopeptides.

List of Research Outputs

Chan C.Y., Garcia J.M., Altmeyer R. and Chu I.K., Mapping of N-Glycosylation sites of spike protein S in severe acute respiratory syndrome virus using tandem mass spectrometry, Poster Presentation in 12th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, April 23, 2005. Hong Kong, Poster No.: AE-20.

Chu I.K., Lam N.W. and Siu S.O., Facile generation of tripeptide radical cations in Vacuo via intramolecular electron transfer in cu II tripeptide complexes containing sterically encumbered terpyridine ligands, Journal of the American Society for Mass Spectrometry. 2005, 16: 763-771.

Chu I.K., Radical Cationic Peptide Formation in Electrospray Tandem Mass Spectrometry, Pacific Northwest National Laboratory, Fundamental Science Directorate,. WA, USA, 2004.

Lam N.W., Siu S.O. and Chu I.K., Efficient formation of peptide radical cations in vacuo by electron transfer of Cu^II(Amine)peptide complexes, Poster Presentation in 12th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, April 23, 2005. Hong Kong, Poster No: AE-22.

Lam N.W., Siu S.O. and Chu I.K., Efficient formation of peptide radical cations in vacuo by electron transfer of Cu^II(Amine)peptide complexes, Poster Presentation in Proceedings of the 53rd ASMS Conference on Mass Spectrometry and Allied Topics, San Antonio, Texas, U.S.A., June 5-9, 2005.

Yu K.Y., Springob K., Schmidt J., Nicholson R.L., Chu I.K., Yip W.K. and Lo C.S.C., A stilbene synthase gene (SbSTS1) is involved in host and nonhost defense responses in sorghum, Plant Physiology. 2005, 138: 393-401.

Yu K.Y., Lam N.W., Lo C.S.C. and Chu I.K., Qualitative and quantitative analysis of flavonoid metabolites in sorghum by liquid chromatograph tandem mass spectrometry, Poster Presentation in 12th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, April 23, 2005. Hong Kong, Poster No: AE-21.

Researcher : Chui SY

List of Research Outputs

Chui S.Y., Ng F.Y. and Che C.M., Structure determination of homoleptic Au^I, Ag^I, and Cu^I Aryl/Alkylethynyl coordination polymers by s-ray powder diffraction, Chemistry - A European Journal. 2005, 11: 1739-1749.

Researcher : Chui YH

List of Research Outputs

Chui Y.H. and Chan G.K.Y., Distribution of platinum and cobalt atoms in a bimetallic nanoparticle, Chemical Physics Letters. 2005, 408: 49-53.

Chui Y.H. and Chan G.K.Y., Structures and energetics of platinum - cobalt bimetallic clusters, Molecular Simulation. 2004, 30(10): 679-690.

Researcher : Chung NW

List of Research Outputs

Chung N.W., Applications of regioselective intramolecular oxidation by dioxirane generated in situ: stereoselective synthesis of substituted tetrahydropyrans and fluorescence probes for peroxynitrite(PhD). 2005.

Researcher : Chung WK

List of Research Outputs

Chung W.K. and Chiu P., Reductive intramolecular Henry reactions induced by Stryker's reagent, Synlett. G. Thieme Verlag, 2004, 55-58.

Chung W.K. and Chiu P., [4+3] Cycloaddition of oxyallyl cations from epoxy enol silanes, The 8^th International Symposium for Chinese Organic Chemists, The Chinese University of Hong Kong, Dec 12-19, 2004. PP-23.

Researcher : Chung WK

List of Research Outputs

Chung W.K. and Chiu P., Reductive intramolecular Henry reactions induced by Stryker's reagent, Synlett. G. Thieme Verlag, 2004, 55-58.

Researcher : Chung WY

List of Research Outputs

Chung W.Y. and Toy P.H., A polystyrene-supported triflating reagent for the synthesis of aryl triflates, Tetrahedron. 2005, 61(3): 709-715.

He S., Chung W.Y., But Y.S. and Toy P.H., Arsonium ylides in organic synthesis, Tetrahedron. 2005, 61(6): 1385-1405.

Researcher : Ding J

List of Research Outputs

Ding J., Chan G.K.Y., Ren J. and Xiao F.S., Platinum and platinum-ruthenium nanoparticles supported on ordered mesoporous carbon and their electrocatalytic performance for fuel cell reactions, Electrochimica Acta. 2005, 50: 3131-3141.

Researcher : Du W

List of Research Outputs

Jin L., Szeto K.Y., Zhang L., Du W. and Sun H., Inactivation of alcohol dehydrogenase by bismuth complex, Journal of Inorganic Biochemistry. 2004, 98: 1331-1337.

Researcher : Du Y

List of Research Outputs

Guan X., Du Y., Li Y., Kwok W.M. and Phillips D.L., Comparison of the dehalogenation of polyhalomethanes and production of strong acids in aqueous and salt (NaCI) water environments: ultraviolet photolysis of CH₂I₂, Journal of Chemical Physics. 2004, 121(17): 8399-8409.

Guan X., Lin X., Kwok W.M., Du Y., Li Y., Zhao C., Wang D. and Phillips D.L., Ultraviolet photolysis of CH₂I₂ in ,methanol: O-H insertion and HI elimination reactions to form a dimethoxymethane product, Journal of Physical Chemistry A. 2005, 109(6): 1247-1256.

Lin X., Guan X., Kwok W.M., Zhao C., Du Y., Li Y. and Phillips D.L., Water-catalyzed O-H insertion/HI elimination reactions of isodihalomethanes (CH₂X-I, where x=CI,Br, I) with water and the dehalogenation of dihalomethanes in water-solvated environments, Journal of Physical Chemistry A. 2005, 109(6): 981-998.

Phillips D.L., Kwok W.M., Zhao C., Guan X., Du Y., Li Y. and Wang D., Water assisted dehalogenation reactions of selected isopolyhalomethanes, halomethanols and haloformaldehydes, Abstract of 229^th ACS National Meeting, San Diego, California, U.S.A., March 13 - March 17, 2005. Phys. 2005.

Zhao C., Lin X., Kwok W.M., Guan X., Du Y., Wang D., Hung K.F. and Phillips D.L., Water-catalyzed dehalogenation reactions of the isomer of CBr₄ and its reaction products and a comparison to analogous reactions of the isomers of d- and trihalomethanes, Chemistry - A European Journal. 2005, 11(4): 1093-1108.

Researcher : Fu W

List of Research Outputs

Lin Y., Lai S.W., Che C.M., Fu W., Zhou Z.Y. and Zhu N., Structural variations and spectroscopic properties of luminescent mono-and multinuclear silver(I) and copper(I) complexes bearing phosphine and cyanide ligands, Inorganic Chemistry. 2005, 44: 1511-1524.

Researcher : Fung CMK

List of Research Outputs

Fung C.M.K. and Chiu P., Intramolecular Reductive-aldol cyclization of enedione systems catalyzed by Stryker's reagent, The 8^th International Symposium for Chinese Orgamic Chemists, The Chinese University of Hong Kong, Dec 12-19, 2004. PP-35.

Researcher : Fung YS

Project Title:	Chemical analysis for quality control/quality assurance in the preparation of traditional Chinese medicine
Investigator(s):	Fung YS, Hui SSC, Jin Q.H.
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2000

Abstract:

To develop an economic and fast methodology based on chemical analysis/factor analysis to improve quality control and quality assurance in Traditional Chinese Medicine (TCM) manufacturing.

Project Title:	Nanotechnology for advanced electrophoretic coating
Investigator(s):	Fung YS, Zhu D, Kwan P.S., Lee X.Y., Liu F.C.
Department:	Chemistry
Source(s) of Funding:	Innovation and Technology Support Programme
Start Date:	03/2002
Completion Date:	08/2004

Abstract:

To develop the Capillary Electrophoretic Nano-particle Sizing Technology (CENST) for the separation and sizing of polymer emulsion at the manometer range; to test and validate the applicability of the CENST technology developed for QA/QC in nano-paint production; to construct a CENST equipment for QA/QC for nanopaint production; to develop the Electrophoretic Nano-coating Technology (ENT) for polymer emulsion coating; to test and validate the applicability of the ENT developed for industrial application; to demonstrate the ENT technology developed in targeted coating industries.

Project Title:	Microfluidic chip-based capillary electrophoresis system for collection, fingerprinting and screening of effective fractions of traditional Chinese medicine after HPLC separation
Investigator(s):	Fung YS, Cheung PT, Lin BC
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2003

Abstract:

To develop an interface between a HPLC column and microchip CE for fingerprinting and collection of the effectivce fractions of Traditional Chinese Medicine (TCM); to validate the collection of the efficiency of the interface developed for isolation of a targeted effective fractions of TCM; to investigate the fingerprinting capability of using multi-channel microfluidic chip-based CE; to screen the effective fractions of TCM using a CE approach developed at Professor Lin's laboratory based on multi-target interaction study for protein-protein, protein-DNA and small molecule interactions; to test the effectiveness of the fractions of TCM isolated using the cell-based bioassay system developed at the Paediatric Department.

Project Title:	PCR-based DNA quartz piezoelectric biosensor for determination of E. Coli in environmental and food samples
Investigator(s):	Fung YS, Ng SP, Yam WC, Yao S.Z., Li Z.
Department:	Chemistry
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	10/2003

Abstract:

To investigate and select a suitable primer and probe for use in the Polymerase Chain Reaction (PCR) to amplify appropriate DNA sequence for E. coli determination using the piezoelectric crystal (PZ) biosensor; to develop and optimize the coating procedure for a single strand Deoxyribonucleic Acid (ssDNA) onto the quartz piezoelectric crystal surface; to investigate the mechanism for the procedures during immobilization and hybridization of ssDNA of E. coli using various techniques based on Scanning Probe Microscope (SPM); to correlate the PCR-based DNA PZ signal with the bacteria count using the real-time PCR and Capillary Electrophoresis (CE) for quantitative determination; to optimize the working conditions, determine the analytical parameters and study the field application of PCR-based DNA quartz PZ biosensor.

Project Title:	PCR-based DNA quartz piezoelectric biosensor for determination of E. Coli in environmental and food samples
Investigator(s):	Fung YS, Ng SP, Yam WC, Yao S.Z., Li Z.
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	10/2003

Abstract:

Project Title:	Quantum dots for optical sensing and detection
Investigator(s):	Fung YS, Jin Q.H.
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2004

Abstract:

To synthesis of Quantum Dots (QDs) semiconductor nano-particles based on the CdTe nano-crystals through an aqueous route with controlled particle size distribution in nano-size range; to use the nano-sized QDs to fabricate various designs of detection windows for microfluidic Lab-on-a-Chip and evaluate their performance; to apply the microfluidic Lab-on-a-Chip and QDs photoluminescence for separation and determination of analytes in environmental and biomedical areas; to develope optical sensors based on QDs.

Project Title:	Microfluidic-based Lab-on-a-Chip Technology Platform: A Multi-Tier and Efficacy-oriented Approach for Screening of Functional Components of Traditional Chinese Medicine
Investigator(s):	Fung YS
Department:	Chemistry
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2004

Abstract:

Refer to hard copy

Project Title:	Application of Microchip Electrophoresis and related methodologies for Respiratory Research
Investigator(s):	Fung YS, Lin BC, Qin JH, Lam WK, Tsang KWT, Ho JCM
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2005

Abstract:

Recent work done at Respiratory Medicine, HKU, had shown the potential role of genetic polymorphisms of glutathione-S-transferases GSTM1, GSTT1 and GSTP1 in susceptibility to lung cancer in Hong Kong Chinese and GSTT1 null genotype was found to associate with an increased risk for lung cancer in non-smoking Chinese in Hong Kong (Lung Cancer (2004) 45, 155-160). This leads to the need in assessing the role of combined genetic polymorphisms of related enzymes in elucidating the etological factors of lung cancer amongst non-smoker in Hong Kong, particular for female in Southern China, as little work has done in this area before. In addition to genetic research, investigation on changes in antioxidant enzyme activities and oxidized glutathione (glutathione, GSSG) in erythrocytes from patients with asthma has been conducted, showing that asthma is accompanied by an alteration in systemic antioxidant status due to possible oxidative stress (J. Allergy & Clinical Immunology, 2004, 114(2) 260-264). Through previous research collaboration between Chemistry Department and Dalian Institute of Chemical Physics, we have developed methodologies based on microchip electrophoresis for genotyping of -6A/G functional polymorphism in the core promoter region of Angiotensingen Gene (Electrophoresis, in press), as well as an ultra-rapid method for simultaneous determination of Reactive Oxygen Species (ROS) and Reduced Glutathione (GSH) in Apoptotic Leukemia cells (Electrophoresis, under review). The genotyping methodology developed based on microchip electrophoresis can be extended for determining other lung cancer related genes such as Interlukin 11G and Interin 1 and the ultrarapid assay for ROS and GSH by microchip electrophoresis (results obtained within 27s) can be adopted after development for analysis in plasma. They will provide suitable methodologies to enhance the work done in respiratory medicine in cancer and asthma research. The objectives of the present proposal are developing the microchip electrophoresis methodologies for the analysis of ROS and related species in plasma, as well as for the determination of genes related to lung cancer such as Interlukin 11G and Interin 1. The tools available will enable conducting a survey of selected population to understand the route from genetic makeup to expression of antioxidants through protein analysis. The information obtained is essential to map the path for carcinogenesis for lung cancer and to understand the effect of antioxidants on asthma patients, producing results needed to identify high risk group and to guide therapeutic treatment for intervention to block pathogenesis development for asthma and cancer patients.

Project Title:	Electrophoretic Nano-coating Technology using Environmental Friendly Water-based Nano-coating System for Corrosion Protection and Decoration of Metal Parts and Components used in Automobiles
Investigator(s):	Fung YS, Zhu D, Lin B.C., Li Z.
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	05/2005

Abstract:

The main objective is to develop the two nanotechnologies, namely Capillary Nano-particle Sizing Technology (CENST) and the Electrophoretic Nanocoating Technology (ENT), which are previously supported by the Innovation and Technology Fund (ITS/125/01), to new processes to produce specific products in the manufacturing of automobile parts and accessories, a rising industrial sector at the Pearl River Delta area. There are three main focus areas for developing the product oriented processes using the two nanotechnologies developed.The first focus area is to develop a transparent polymeric coating layer with main focus on corrosion protection of aluminium and magnesium based alloys. They can be used for functional coating or for coating parts with decorative appearance. Fundamental investigations have to be performed to study the pore structure of the protective oxide layer formed during industrial production of aluminium and magnesium alloys and to investigate the size distribution effect of nano-emulsion on coating formed at various pore structures as identified. The composition of the electrophoretic bath needs to be developed and the working conditions of ENT established under the best performance. In addition, the working conditions of CENST needed to be optimized for QA/QC of the ENT processes. The second area is developing coating using nanoemulsion and a mixture of dyes to achieve a combined function on corrosion protection and decorative finish. It will aim at achieving both functions using a single coating process. The third area will focus on the co-deposition of nano-composites with metal particles, dyes and nanoemusion to produce desirable patterns for highly decorative parts. All the processes developed use the environmental friendly water-based system. Blending nano-emulsion with other polymer particles will be investigated in the above three processes to produce an Interpenetration Network structure to achieve a desirable coating layer with suitable thickness and to reduce cost.

List of Research Outputs

Fung Y.S., Capillary electrophoresis for environmental analysis, Abstract of DICP Symposium (V) on Micro-scale Separations and Analysis for System Biology, Dec 10-11,2004, Dalian, China. 2004, 15.

Fung Y.S., Capillary electrophoresis for environmental analysis, Invited lecture at Plenary Session of Symposium on Micro-scale Separations and Analysis for System Biology (DICP V), Dalian, China, Dec 10-11. 2004.

Fung Y.S., Guest Professor, Dongguan Institute of Technology, Guangdong, China, 1999 - June 2005. 2005.

Fung Y.S., Guest Professor, High Molecular Polymer Material and Engineering Research Institute, Material Science and Engineering Faculty, Jilin University, China, 2003- June 2005. 2005.

Fung Y.S., International Board member, 2004-2005, 1st Asian and 9th China-Japan Bilateral Conference on Molten Salt Chemistry and Technology, Wuhu, Anhui, China, May 23-29, 2005. 2004.

Fung Y.S., Member of 1^st Molten Salt Committee from the Physical Metallurgical Chemistry Professional Committee, 2003 - 2005, Chinese Metal Society. 2004.

Fung Y.S., Member of Editorial Board, Chemistry Education, published by the Chinese Chemical Society, April 2000 - March 2005. 2004.

Fung Y.S., Member of Editorial Board, In: Elsevier, Amsterdam, The Netherlands, Journal of Biochemical and Biophysical Methods. The Netherlands, Elsevier, 2005.

Fung Y.S., Member of Editorial Board, Journal of Biochemical and Biophysical Methods, Elsevier, Amsterdam, The Netherlands, Jan 2005 - Dec 2007. 2005.

Fung Y.S., Member of Scientific Committee, 2004-2005, The 5^th Asian Conference on Electrochemistry (ACEC 2005), Shanghai, China, May 9-12, 2005. 2004.

Fung Y.S., Member, 2003 - 2005, International Advisory Board and Scientific Committee, 5th Asia-Pacific International Symposium on Microscale Separation and Analysis (APCE 2004), held at Seoul, Korea, December 5-8. 2004.

Fung Y.S., Si S., Zhu D. and Sun H., Nanoporous TiO₂ film as coating for piezoelectric crystal sensor in the detection of organic vapours in air , Abstract of the 10^th International Meeting on Chemical Sensors (IMCS-10), Tsukuba, Japan, July 11-14, 2004, 3P029. 2004.

Fung Y.S., Si S., Zhu D. and Sun H., Nanoporous TiO₂ film as coating for piezoelectric crystal sensor in the detection of organic vapours in air , Chemical Sensors. 2004, 20: 698-699.

Fung Y.S., Oxygen flask combustion, In: (Eds Paul J. Worsfold, Alan Townshend and Colin F. Poole), Encyclopedia of Analytical Science,Second Edition. Oxford, Elsevier, 2005, 5: 137-146.

Fung Y.S., Sun H., Zhang Y., Yao S. and Yam W.C., PCR/DNA piezoelectric quartz crystal biosensor for bacteria sensing, Abstract of 2^nd France China Workshop on Surface Molecules of Biological Interest: Biosensor Applications, October 13-16, 2004, Céret, France, p 36. 2004, 36.

Fung Y.S., Sun H., Zhang Y., Yao S.Z. and Yam W.C., PCR/DNA piezoelectric quartz crystal biosensor for bacteria sensing, Invited lecture at Plenary Session of 2^nd France China Workshop on Surface Molecules of Biological Interest: Biosensor Application, Céret, France, October 13-16. 2004.

Fung Y.S., Yam W.C., Zhang Y. and Sun H., PCR/DNA quartz crystal microbalance biosensor for detecting bacteria in environmental water samples, Abstract of The 56^th Annual Pittsburgh Conference and Exposition on Analytical Chemistry and Applied Spectroscopy (PITTCONF 2005), Orlando, Florida, USA, February 27-March 4,2005, 2250-5. 2005, 2250-2255.

Fung Y.S., Gong F. and You T., Sensing beverage tastes from organic acids separated by capillary electrophoresis and assessed by pattern recognition, Abstract of the 10^th International Meeting on Chemical Sensors (IMCS-10), Tsukuba, Japan, July 11-14, 2004, 2P050. 2004.

Fung Y.S., Gong F. and You T., Sensing beverage tastes from organic acids separated by capillary electrophoresis and assessed by pattern recognition, Chemical Sensors. 2004, 20: 480-481.

Fung Y.S., Sun D. and Yeung C.Y., Separation, quantitation and binding study of serum proteins with bilirubin by capillary electrophoresis under physiological conditions, Abstract of 5^th Asia-Pacific International Symposium on Microscale Separation and Analysis (APCE2004), Seoul, South Korea, Dec 5-8, 2004, P10. 2004, p76.

Gong F., Fung Y.S. and Liang Y., Determination of volatile components in ginger using gas chromatography-mass spectrometry with resolution improved by data processing techniques, Journal of Agricultural and Food Chemistry. 2004, 52: 6378-6383.

Gong F. and Fung Y.S., Resolving chromatographic fingerprints from GC-MS of Asarum by chemometric techniques, Abstract of 7^th Asian conf. on anal. Sci., Hong Kong SAR, China, July 28-31, 2004, A022-O. 2004, p26.

Qin J., Ye N., Yu L., Fung Y.S. and Lin B., Simultaneous determination of reactive oxygen species and reduced glutathione in apoptotic leukaemia cells by capillary electrophoresis, Abstract of 5^th Asia-Pacific International Symposium on Microscale Separation and Analysis (APCE2004), Seoul, South Korea, Dec 5-8, 2004, P26. 2004, p92.

Qin J.H., Liu Z.Y., Wu D.P., Zhu N., Zhou X.M., Fung Y.S. and Lin B.C., Genotyping the -6A/G functional polymorphism in the core promoter region of angiotensinogen gene by microchip electrophoresis, Electrophoresis. 2005, 26: 219-224.

Qin J.H., Leung F.C.C., Fung Y.S., Zhu D. and Lin B.C., Rapid authentication of ginseng species using microchip electrophoresis with laser-induced fluorescence detection, Analytical and Bioanalytical Chemistry . 2005, 381: 812-819.

Qin J.H., Ye N.N., Yu L.F., Liu D.Y., Fung Y.S., Wang W., Ma X.J. and Lin B.C., Simultaneous and ultrarapid determination of reactive oxygen species and reduced glutathione in apoptotic leukemia cells using microchip electrophoresis, Electrophoresis. 2005, 26: 1155-1162.

Si S., Fung Y.S. and Hu H., Photoelectrochemical biosensor based on formaldehyde dehydrogenase/CdTe Nanoparticles, Abstract of 7^th Asian conf. on Anal. Sci., Hong Kong, July 28-31, 2004, F054-P, p352. 2004, p352.

Sun H. and Fung Y.S., Determination of atmospheric carbonyl compounds by MIP-SPE coupled MEKC method, Abstract of 7^th Asian Conf. on Anal. Sci., Hong Kong, July 28-31, 2004, H074-P. 2004, p486.

Sun H., Chan K.Y. and Fung Y.S., Integrating MEKC with sampling and pre-treatment for gaseous and particulate carbonyl determination, Abstract of 5^th Asia-Pacific International Symposium on Microscale Separation and Analysis (APCE2004), Dec 5-8, 2004, Seoul, South Korea. 2004, 024: 44.

Sun H., Chan K.Y. and Fung Y.S., Integrating MEKC with sampling and pre-treatment for gaseous and particulate carbonyl determination, Invited lecture at Plenary Session of the 5th Asia-Pacific International Symposium on Microscale Separation and Analysis (APCE2004), Seoul, South Korea, Dec 5-8 . 2004.

Sun H., Si S., Zhang Y., Zhu D. and Fung Y.S., Piezoelectric quartz crystal (PQC) with photochemically deposited nano-sized Ag particles for determinig cyanide at trace levels in water, Chemical Sensors. 2004, 20: 500-502.

Sun H., Si S., Zhang Y., Zhu D. and Fung Y.S., Piezoelectric quartz crystal (PQC) with photochemically deposited nano-sized Ag particles for determining cyanide at trace levels in water, Abstract of the 10^th International Meeting on Chemical Sensors (IMCS-10), Tsukuba, Japan, July 11-14, 2004, 2P061. 2004.

You T., Sun H. and Fung Y.S., Electrochemical detector for indirect detection of amino acids after CE separation, Abstract 7^th Asian Conf. on Anal. Sci., Hong Kong SAR, China, July 28-31, 2004, F079-P. 2004, p491.

Zhang Y., Sun H., Fung Y.S. and Yao S., Quantitative determination of bacteria by DNA piezoelectric biosensor, Abstract of 7^th Asian conf. on anal. Sci., Hong Kong SAR, China, July 28-31, 2004, E063-P. 2004, p296.

Zhang Y., Fung Y.S. and Yao S., Study of protein adsorption on polymer coatings surface by quartz crystal microbalance and electrochemical impedance methods, Abstract of the 10^th International Meeting on Chemical Sensors (IMCS-10), Tsukuba, Japan, July 11-14, 3P064. 2004.

Zhang Y., Fung Y.S. and Yao S., Study of protein adsorption on polymer coatings surface by quartz crystal microbalance and electrochemical impedance methods, Chemical Sensors. 2004, 20: 760-761.

Zhao L., You T. and Fung Y.S., Characterization of nanoparticles by gas-phase electrophoretic mobility molecular analyser (GEMMA) :Electrospray diagnostics, Abstract of 7^th Asian Conf. on anal. Sci., Hong Kong, July 28-31, 2004, F084-P. 2004, p496.

Zhu D., Sun H. and Fung Y.S., Electrochemical performance of nano-TiO2 modified LiCoO2 cathode material in room temperature molten salts for lithium battery application, Invited lecture at Electrodeposition Session of 1^st Asian and 9^th China-Japan Bilateral Conference on Molten Salt Chemistry and Technology, Wuhu, China, May 23-27. 2005.

Zhu D., Sun H. and Fung Y.S., Electrochemical performance of nano-TiO2 modified LiCoO2 cathode material in room temperature molten salts for lithium battery application, Proceedings 1^st Asian and 9^th China-Japan Bilateral Conference on Molten Salt Chemistry and Technology, Wuhu, China, May 23-27, 2005, 54-57. 2005, 54-57.

Researcher : Gao Q

List of Research Outputs

Gao Q., Zheng B., Li J. and Yang D., Ni(II)-catalyzed conia-ene reaction of 1,3-dicarbonyl compounds with alkynes, Organic Letters. 2005, 7(11): 2185-2188.

Yang D., Gao Q., Zheng B. and Zhu N., Et²ALCL-Promoted asymmetric phenylseleno group transfer radical cyclization reactions of unsaturated b-hydroxy esters, Journal of Organic Chemistry. 2004, 69(25): 8821-8828.

Researcher : Ge R

List of Research Outputs

Sun H., Ge R., Watt R.M., He Q. and Huang J., Towards the understanding of nickel trafficking in helicobacter pylori: Expression and characterization of a his-rich protein, HPN, 10th SCBA International Symposium, Beijing, China, 18-23 July 2004.

Sun X., Sun H., Ge R., Richter M., Woodworth R.C., Mason A.B. and He Q., The low pK_a value of iron-binding ligand tyr188 and its implication in iron release and anion binding of human transferrin, FEBS Letters. 2004, 573(1-3): 181-185.

Researcher : Ge R

List of Research Outputs

Researcher : Geng Z

List of Research Outputs

Geng Z., Synthetic studies towards pseudolaric acids(PhD). 2004.

Researcher : Gong F

List of Research Outputs

Fung Y.S., Gong F. and You T., Sensing beverage tastes from organic acids separated by capillary electrophoresis and assessed by pattern recognition, Abstract of the 10^th International Meeting on Chemical Sensors (IMCS-10), Tsukuba, Japan, July 11-14, 2004, 2P050. 2004.

Fung Y.S., Gong F. and You T., Sensing beverage tastes from organic acids separated by capillary electrophoresis and assessed by pattern recognition, Chemical Sensors. 2004, 20: 480-481.

Gong F., Fung Y.S. and Liang Y., Determination of volatile components in ginger using gas chromatography-mass spectrometry with resolution improved by data processing techniques, Journal of Agricultural and Food Chemistry. 2004, 52: 6378-6383.

Gong F. and Fung Y.S., Resolving chromatographic fingerprints from GC-MS of Asarum by chemometric techniques, Abstract of 7^th Asian conf. on anal. Sci., Hong Kong SAR, China, July 28-31, 2004, A022-O. 2004, p26.

Researcher : Guan X

List of Research Outputs

Guan X., Du Y., Li Y., Kwok W.M. and Phillips D.L., Comparison of the dehalogenation of polyhalomethanes and production of strong acids in aqueous and salt (NaCI) water environments: ultraviolet photolysis of CH₂I₂, Journal of Chemical Physics. 2004, 121(17): 8399-8409.

Guan X., Tse M.K., Yang Y., Sze K.H., Cheung K.K. and Wong K.B., Structure and dynamics of a thermophilic acylphosphatase from Pyrococcus horikoshii by NMR spectroscopy - structural basis of thermostability and enzymatic activities, Twelfth Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong, The City University of Hong Kong, 23 Apr. 2005. 43.

Guan X., Lin X., Kwok W.M., Du Y., Li Y., Zhao C., Wang D. and Phillips D.L., Ultraviolet photolysis of CH₂I₂ in ,methanol: O-H insertion and HI elimination reactions to form a dimethoxymethane product, Journal of Physical Chemistry A. 2005, 109(6): 1247-1256.

Lin X., Guan X., Kwok W.M., Zhao C., Du Y., Li Y. and Phillips D.L., Water-catalyzed O-H insertion/HI elimination reactions of isodihalomethanes (CH₂X-I, where x=CI,Br, I) with water and the dehalogenation of dihalomethanes in water-solvated environments, Journal of Physical Chemistry A. 2005, 109(6): 981-998.

Phillips D.L., Kwok W.M., Zhao C., Guan X., Du Y., Li Y. and Wang D., Water assisted dehalogenation reactions of selected isopolyhalomethanes, halomethanols and haloformaldehydes, Abstract of 229^th ACS National Meeting, San Diego, California, U.S.A., March 13 - March 17, 2005. Phys. 2005.

Sze K.H., Yang Y., Guan X., Tse M.K. and Barsukov I., Combined computational and experimental developments for automated determination of protein structures by NMR, XXI International Conference on Magnetic Resonance in Biologicall Systems, Hyderabad, India, 16-21 Jan, 2005. 94.

Sze K.H., Lin D., Liu X., Yang Y., Guan X. and Zhu G., Mapping protein-protein interactions by solvent exposed amides experiment, XXI International Conference on Magnetic Resonance in Biologicall Systems, Hyderabad, India, 16-21 Jan, 2005. 95.

Sze K.H., Yang Y., Guan X., Tse M.K., Cheung K.K. and Wong K.B., Structure and dynamics of a thermophilic acylphosphatase from Pyrococcus horikoshii by NMR spectroscopy - structural basis of thermostability and enzymatic activities, XXI International Conference on Magnetic Resonance in Biologicall Systems, Hyderabad, India, 16-21 Jan, 2005. 155.

Yang Y., Guan X., Tse M.K., Sze K.H. and Haynes R.K., Eluciation of solution conformations of loloatins by NMR spectroscopy, The 12^th Symposium on Chemistry Postgraduate Research in Hong Kong, The City University of Hong Kong, Hong Kong, Apr 23,2005. 45.

Zhao C., Lin X., Kwok W.M., Guan X., Du Y., Wang D., Hung K.F. and Phillips D.L., Water-catalyzed dehalogenation reactions of the isomer of CBr₄ and its reaction products and a comparison to analogous reactions of the isomers of d- and trihalomethanes, Chemistry - A European Journal. 2005, 11(4): 1093-1108.

Researcher : Hao Y

List of Research Outputs

Hao Y., Zhang D., Zhu N. and Yang D., Conformational studies of b^2,3-cyclic aminoxy peptides, The 12^th Symposium on Chemistry Postgraduate Research in Hong Kong, The City University of Hong Kong, April 23,2005.

Yang D., Zhang D.W., Hao Y., Wu Y.D., Luo S.W. and Zhu N., b²,³ - Cyclic aminoxy acids:rigid and ring-size-independent building blocks of foldamers, Angewandte Chemie International Edition. 2004, 43: 6719-6722.

Researcher : He L

List of Research Outputs

He L., Chan P.W.H., Tsui W.M., Yu W.Y. and Che C.M., Ruthenium(II) porphyrin-catalyzed amidation of aromatic heterocycles , Organic Letters. 2004, 6: 2405-2408.

Researcher : He Q

Project Title:	Molecular dynamics of iron transport
Investigator(s):	He Q
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	12/2002

Abstract:

(1) How the chemical properties of the critical metal-binding ligands affect iron binding and release from transferrin in vitro. (2) How a depleted level of transferrin (and iron) in living cells affects the expression of related proteins in the iron-transport pathway. (3) Study the cellular trafficking of transferrin as a possible pathway for delivering drugs and nano-particles besides iron.

Project Title:	Identification of biomarkers for the diagnosis and therapy of Hepatitis B virus (HBV) infection and HBV-induced hepatocellular carcinoma
Investigator(s):	He Q, Lau G, Chiu J
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	08/2003
Completion Date:	09/2004

Abstract:

To identify the protein markers associated with HBV inflammation and HBV-related HCC liver cancer by using proteomic technology.

Project Title:	Structure-function of the lipoprotein MtsA in MtsABC responsible for iron transport in S. pyogenes bacteria
Investigator(s):	He Q
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2004
Completion Date:	02/2005

Abstract:

To study the structure-function of the lipoprotein MtsA and further to characterize the protein's property in the Mts ABC complex as an entire system.

Project Title:	Proteomic study of hepatitis B virus (HBV) infection and HBV-related liver necroinflammation
Investigator(s):	He Q
Department:	Chemistry
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2004

Abstract:

Refer to hard copy

Project Title:	Proteomic profiling of cellular responses to chromium (Cr) cytotoxicity
Investigator(s):	He Q
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2005

Abstract:

refer hard copy proposal

List of Research Outputs

Cai Z., Chiu J. and He Q., Application of proteomics in the study of tumor metastasis, Genomics Proteomics & Bioinformatics. 2004, 2(3): 152-166.

Cheung Y.T., He Q., Li M., Leung S.Y., Chiu J., Lin M.C. and Kung H., Characterization of human cell cycle related kinase in glioblastoma carcinogenesis by a proteomic study, Advances in Proteomics in Cancer Research, Florida, USA, October 1,2004.

Everse S.J., Halbrook P.J., He Q., Smith V.C., MacGillivray R.T.A. and Mason A.B., Structural and functional consequences of the substitution of arginine for glycine 65 in the human transferrin N-lobe, BioIron 2005, Prague, Czech Republic, May 1,2005.

He Q., Cheung Y.H., Leung S.Y., Yuen S.T., Chu K.M. and Chiu J., Diverse proteomic alterations in gastric adenocarcinoma, Proteomics. 2004, 4(10): 3276-3287.

He Q., Proteomics and its application in biomarker discovery and drug development, Invited lecture at the 2^nd Worldwide Chinese High-Tech Chemistry Conference, Chengdu, China, Aug 1. 2004.

He Q., Proteomics application in biomedical research, Invited lecture at Xi'an Jiao-Tong University, Xi'an, China, May 1. 2005.

He Q., Proteomics for biomedical research, Invited lecture at Sichuan University, Chengdu, China, Aug 1. 2004.

He Q., Zhu R., Ren Y., Tam P.K.H. and Chiu J., Serological protein profiling of neuroblastoma by proteinchip SELDI-TOF technology, Journal of Cellular Biochemistry. 2005, 95: 165-172.

Li F., Li H., Hu L., Kwan M.F., Chen G., He Q. and Sun H., Structure, assembly, and topology of the G185R mutant of the fourth transmembrane domain of divalent metal transporter, Journal of the American Chemical Society. 2005, 127(5): 1414-1423.

Li H., Li F., Kwan M.F., He Q. and Sun H., NMR structres and orientation of the fourth transmembrane domain of the rat divalent metal transporter (DMT1) with G185D mutation in SDS micelles, Biopolymers. 2005, 77: 173-183.

Lo A.C.Y., Tsui M.M.K., Hung K.L., Yaw L.P., He Q., Chiu J., Chung S.S.M. and Chung S.K., Proteomics analysis in transgenic mice over-expressing endothelin-1 in astrocytes after transient focal cerebral ischemia (Poster presentation), The XXIInd International Symposium on Cerebral Blood Flow, Metabolism, and Function & VIIth International Conference on Quantification of Brain Function with PET, Amsterdam, The Netherlands, June 7-11. 2005.

Luk J.M.C., Lee C.K.F., Su Y.C.F., Lam C.T., Hu M.Y., He Q., Lau G., Wong W.S. and Fan S.T., Proteomic identification of Ku70/Ku80 autoantigen recognized by monoclonal antibody against hepatocellular carcinoma (Abstract), HUPO 3rd Annual World Congress, Beijing, China, 25-27 October 2004.

Luk J.M.C., Su Y.C.F., Lam C.T., Lee C.K.F., Hu M.Y., He Q., Lau G., Wong F.W.S. and Fan S.T., Proteomic identification of Ku70/Ku80 autoantigen recognized by monoclonal antibody against hepatocellular carcinoma, Proteomics. 2005, 5(7): 1980-1986.

Qi Y., Chiu J., Wang L., Kwong D.L.W. and He Q., Comparative proteomic analysis of esophageal squamous cell carcinoma, Proteomics. 2005, 5(11): 2960-71.

Ren Y., He Q., Fan J.Q., Jones B., Zhou Y., Xie Y., Cheung C.Y., Wu A.Y.Y., Chiu J., Peiris J.S.M. and Tam P.K.H., The use of proteomics in the discovery of serum biomarkers from patients with severe acute respiratory syndrome, Proteomics. 2004, 4: 3477-3484.

Sun H., Ge R., Watt R.M., He Q. and Huang J., Towards the understanding of nickel trafficking in helicobacter pylori: Expression and characterization of a his-rich protein, HPN, 10th SCBA International Symposium, Beijing, China, 18-23 July 2004.

Sun X., Sun H., Ge R., Richter M., Woodworth R.C., Mason A.B. and He Q., The low pK_a value of iron-binding ligand tyr188 and its implication in iron release and anion binding of human transferrin, FEBS Letters. 2004, 573(1-3): 181-185.

Wang Y., He Q., Che C.M. and Chiu J., Gold porphyrin (III) 1a induced apoptosis by caspase dependent and independent mitochondrial death pathways dependent of reactive oxygen species, 96^th Annual Meeting of AACR, Anaheim, CA, April 16-20. 2005.

Wang Y., He Q., Che C.M. and Chiu J., Gold porphyrin(III) 1a induced apoptosis through caspase-dependent and -independent mitochondrial death pathways regulated by reactive oxygen species, ASBMB Annual Meeting, SD, USA, April 16-21. 2005.

Wang Y., Chiu J. and He Q., Proteomics in computer-aided drug design, Current Computer-Aided Drug Design. 2005, 1: 43-52.

Yang P., Sun X., Chiu J., Sun H. and He Q., Transferrin-mediated gold nanoparticle cellular uptake, Bioconjugate Chemistry. 2005, 16: 494-496.

Researcher : He S

List of Research Outputs

Harned A.M., He S., Toy P.H., Flynn D.L. and Hanson P.R., Multipolymer solution-phase reactions: application to the mitsunobu reaction, Journal of the American Chemical Society. 2005, 127(1): 52-53.

He S., Chung W.Y., But Y.S. and Toy P.H., Arsonium ylides in organic synthesis, Tetrahedron. 2005, 61(6): 1385-1405.

He S., But Y.S. and Toy P.H., Polymer-supported triphenylamine, triphenylarsine and triphenylphosphine reagents, International Conference on Heteroatom Chemistry, Shanghai, China, August 21-25, 2004.

Lau C.Y., He S., Chiu P. and Toy P.H., Polystyrene-supported triphenylarsine reagents and their use in Suzuki cross-coupling reactions, Journal of Combinatorial Chemistry. 2004, 6(6): 955-960.

Toy P.H. and He S., Development of polymer-supported triphenylarsine and triphenylphosphine reagents, American Chemical Society National Meeting, San Diego, California, USA, March 13-17, 2005.

Zhao L.J., He S., Shi M. and Toy P.H., Polystyrene-supported phosphine-catalyzed aza-baylis-hillman reactions and the relationship between resin loading level and catalyst efficiency, Journal of Combinationial Chemistry. 2004, 6(5): 680-683.

Researcher : Ho CY

List of Research Outputs

Ho C.Y., Chen Y., Wong M.K. and Yang D., Fluorinated chiral secondary amines as catalysts for epoxidation of olefins with oxone, The Journal of Organic Chemistry. 2005, 70: 898-906.

Researcher : Hou Y

List of Research Outputs

Lai S.W., Hou Y., Che C.M., Pang H.L., Wong K.Y., Chang C.K. and Zhu N., Electronic Spectroscopy, Photophysical Properties, and Emission Quenching Studies of an Oxidatively Robust Perfluorinated Platinum Porphyrin, XX IUPAC Symposium on Photochemistry, Granada, Spain, 17-22 July. 2004.

Lai S.W., Hou Y., Che C.M., Peng H.L., Wong K.Y., Chang C.K. and Zhu N., Electronic spectroscopy, photophysical properties, and emission quenching studies of an oxidatively robust perfluorinated platinum porphyrin, 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), The University of Hong Kong, Hong Kong, P. R. China, 4-9 July. 2004.

Researcher : Hu H

List of Research Outputs

Si S., Fung Y.S. and Hu H., Photoelectrochemical biosensor based on formaldehyde dehydrogenase/CdTe Nanoparticles, Abstract of 7^th Asian conf. on Anal. Sci., Hong Kong, July 28-31, 2004, F054-P, p352. 2004, p352.

Researcher : Hu L

List of Research Outputs

Hu L., Application of neural networks in the first principles calculations and computer-aided drug design(PhD). 2005.

Li F., Li H., Hu L., Kwan M.F., Chen G., He Q. and Sun H., Structure, assembly, and topology of the G185R mutant of the fourth transmembrane domain of divalent metal transporter, Journal of the American Chemical Society. 2005, 127(5): 1414-1423.

Wang X., Wong L.H., Hu L., Chan C.Y., Su Z. and Chen G., Improving the accuracy of density-functional theory calculation: the statistical correction approach, Journal of Physical Chemistry A. 2004, 108(40): 8514-8525.

Researcher : Huang JS

Project Title:	Unusual metal-phosphorus bonded metalloporphyrins
Investigator(s):	Huang JS
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004

Abstract:

To develop novel chemistry of metalloporphyrins with metal-phosphorus (M-P) bonds, including (i) the syntheses and reactivities of metalloporphyrins bearing primary/secondary phosphine, halophosphine, polyphosphine, phosphido, and phosphinidene ligands and (ii) multi metalloporphyrin assemblies linked by bidentate P-ligands.

Project Title:	Iron, Ruthenium, and Osmium Phosphinidene and Sulfido Complexes: Phosphorus or Sulfur Atom Transfer Reactions and Models for Native Iron-Sulfur Clusters
Investigator(s):	Huang JS
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2004

Abstract:

To develop the chemistry of (1) metal-phosphorus multiple bonds in metallomacrocycles or metallosalens, (2) metal-sulfur multiple bonds in iron, ruthenium, or osmium complexes, (3) ruthenium or osmium analogues of biologically important iron-sulfur clusters. The ultimate goals are to realize metal catalyzed C P bond formation reactions such as phosphirane formation alkenes, to develop new metal cat alysts for the C-S bond formation reactions such as alkene episulfidation, and to synthesize new structural or functional models for the active sites of iron-sulfur proteins or nitrogenase.

Project Title:	Iron, Ruthenium, and Osmium Phosphinidene and Sulfido Complexes: Phosphorus or Sulfur Atom Transfer Reactions and Models for Native Iron-Sulfur Clusters
Investigator(s):	Huang JS
Department:	Chemistry
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

Project Title:	Metalloporphyrin- and metallosalen-mediated imine functionalizations
Investigator(s):	Huang JS
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2005

Abstract:

refer hard copy proposal

List of Research Outputs

Huang J.S., Leung K.Y., Zhou Z.Y., Zhu N. and Che C.M., Tuning the Reactivity of Dioxoruthenium(VI) Porphyrins toward anArylimine by Altering Porphyrin Substituents, Inorganic Chemistry. 2005, 44: 3780-3788.

Li Y., Huang J.S., Xu G.B., Zhu N., Zhou Z.Y., Che C.M. and Wong K.Y., Spectral, structural, and electrochemical properties of ruthenium porphyrin diaryl and aryl(alkoxycarbonyl) carbene complexes: influence of carbene substituents, porphyrin substituents, and trans-axial ligands, Chemistry A European Journal. 2004, 10: 3486-3502.

Mao Z., Huang J.S., Che C.M., Zhu N., Leung K.Y. and Zhou Z.Y., Unexpected reactivities of Cu₂(diphosphine)₂ complexes in alcohol: isolation, x-ray crystal structure, and photoluminescent properties of a remarkably stable [Cu₃(diphosphine)₃(m₃ - H)]²⁺ hydride complex, Journal of the American Chemical Society. 2005, 127(13): 4562-4563.

Xie J., Huang J.S., Zhu N., Zhou Z.Y. and Che C.M., Primary and secondary phosphane complexes of metalloporphyrins: isolation, spectrocscopy, and x-ray crystal structures of ruthenium and osmium porphyrins binding phenyl- or diphenylphosphane, Chemistry - A European Journal. 2005, 11: 2405-2416.

Researcher : Hui CS

List of Research Outputs

Chan W.K., Man K.Y.K., Hui C.S. and Wong H.L., The use of metal containing polymers as photo-sensitizing materials, 15th International Symposium on Photophysics and Photochemistry of Coordination Compounds, Hong Kong, July 4-9, 2004.

Researcher : Hung KF

List of Research Outputs

Zhao C., Lin X., Kwok W.M., Guan X., Du Y., Wang D., Hung K.F. and Phillips D.L., Water-catalyzed dehalogenation reactions of the isomer of CBr₄ and its reaction products and a comparison to analogous reactions of the isomers of d- and trihalomethanes, Chemistry - A European Journal. 2005, 11(4): 1093-1108.

Researcher : Hung LL

List of Research Outputs

Wong M.C., Zhu X., Hung L.L., Zhu N., Yam V.W.W. and Kwok H.S., A novel class of phosphorescent gold(III) alkynyl-based organic light emitting devices with tunable color, Chemical Communications. 2005, 2906-2908.

Yam V.W.W., Wong M.C., Hung L.L. and Zhu N., Unprecedented luminescent gold(III) alkynyl complexes - synthesis, structural characterization and luminescent properties, Angewandte Chemie International Edition. 2005, 44: 3107-3110.

Researcher : Jin L

List of Research Outputs

Jin L., Szeto K.Y., Zhang L., Du W. and Sun H., Inactivation of alcohol dehydrogenase by bismuth complex, Journal of Inorganic Biochemistry. 2004, 98: 1331-1337.

Yan S.C., Jin L. and Sun H., ⁵¹ Sb-antimony in medicine, Metallotherapeutic Drugs and Metal-Based Diagnostic Agents: The Use of Metals in Medicine. John Wiley & Sons, Ltd, 2005, 441-461.

Researcher : Kan TW

List of Research Outputs

Kan T.W. and Toy P.H., Poly(ethylene glycol)-supported a,a,a-trifluoroacetophenone in dioxirane mediated alkene epoxidation reactions, Tetrahedron Letters. 2004, 45(33): 6357-6359.

Ma C., Zuo P., Kwok W.M., Chan W.S., Kan T.W., Toy P.H. and Phillips D.L., Time-resolved resonance raman study of the triplet states of p-hydroxyacetophenone and the p-hydroxyphenacyl diethyl phosphate phototrigger compound, Journal of Organic Chemistry. 2004, 69(20): 6641-6657.

Ma C., Kwok W.M., Chan W.S., Zuo P., Kan T.W., Toy P.H. and Phillips D.L., Ultrafast time-resolved study of photophysical processes involved in the photodeprotection of p-Hydroxyphenacyl caged phototrigger compounds, Journal of the American Chemical Society. 2005, 127(5): 1463-1472.

Researcher : Ko CB

Project Title:	Transgenic mice approach to elucidating the role of osmotic response element binding protein (OREBP) in water homeostasis
Investigator(s):	Ko CB, Chung SSM
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2002

Abstract:

The project aims at understanding the physiological role of osmotic response element binding protein (OREBP) in kidney by developing transgenic mice that overexpress a dominant negative mutant of this protein in the inner medullary collecting ducts. It is anticipated that this study would reveal the role of OREBP in urine concentrating mechanism.

Project Title:	Mechanism of nucleocytoplasmic shuttling of OREBP/TonEBP
Investigator(s):	Ko CB, Chung SSM
Department:	Chemistry
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	09/2003

Abstract:

To elucidate the role of Crm-1 in hypotonicity-induced nuclear export of OREBP; to define the minimal domain in OREBP required for the nuclear import and export functions; to examine the role of histone deacetylases in regulation of hypotonicity-induced OREBP nuclear export.

Project Title:	Mechanism of nucleocytoplasmic shuttling of OREBP/TonEBP
Investigator(s):	Ko CB, Chung SSM
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2003

Abstract:

Project Title:	The role of osmotic response element binding protein in the hypertonic induction of p53
Investigator(s):	Ko CB
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004

Abstract:

To elucidate the role of OREBP in the phypertonic-induction of p53, and to explore the role of p53 in mediating the expression of OREBP-dependent genes.

Project Title:	The mechanism of OREBP/TonEBP/NFAT5-dependent transcription - role of signaling pathway and chromatin remodeling
Investigator(s):	Ko CB, Chung SSM, Rao A.
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	01/2005

Abstract:

To examine the correlation between OREBP-recruitment to different promoters and the kinetics of OREBP-dependent gene expressions; to evaluate the role of histone modification in OREBP-dependent gene transcription and the role of IKK and p38 in histone phosphorylation at OREBP-dependent promoters; to investigate the role of p300/CBP in histone modification and OREBP transcription activation.

Project Title:	The mechanism of OREBP/TonEBP/NFAT5-dependent transcription - role of signaling pathway and chromatin remodeling
Investigator(s):	Ko CB
Department:	Chemistry
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

List of Research Outputs

Ko C.B., Wong K.W., Chiu P., Chung S.S.M., Chow L.M. and Yang B.B., Pseudolaric acid B as a new class of microtubule destabilizing agent and an effective anti-tumor compound in vivo, Abstract of 44^th Annual Meeting of The American Society for Cell Biology, Washington Convention Center, Washington, DC, U.S.A. December 4-8,2004.

Lam A.K.M., Ko C.B., Tam S., Morris R., Yang J.Y., Chung S.K. and Chung S.S.M., Osmotic response element binding protein (OREBP) is an essential regulator of urine concentrating mechanism, Journal of Biological Chemistry. 2004, 279: 48048-54.

Li Z., Liao C., Ko C.B., Shan S., Tong H.Y., Yin Z., Pan D., Wong K.W., Shi L., Ning Z.Q., Hu W., Zhou J., Chung S.S.M. and Lu X.P., Design, synthesis, and evaluation of a new class of noncyclic 1,3-dicarbonyl compounds as PPARa selective activators, Bioorganic & Medicinal Chemistry Letters . 2004, 14: 3507-3511.

Liu Y., Wong K.W., Ko C.B., Wong M.K. and Che C.M., Synthesis and cytotoxicity studies of artemisinin derivatives containing lipophilic alkyl carbon chains, Organic Letters. 2005, 7: 1561-1564.

Wang Y., Ko C.B., Yang J.Y., Lam T.L., Jiang Z., Zhang Z., Chung S.K. and Chung S.S.M., Transgenic mice expressing dominant-negative osmotic-response element-binding protein (OREBP) in lens exhibit fiber cell elongation defect associated with increased DNA breaks, The Journal of Biological Chemistry. 2005, 280: 19986-199991.

Researcher : Ko CC

Project Title:	Synthesis and studies of a new class of photochromic phenanthroline ligands and their zinc complexes
Investigator(s):	Ko CC, Yam VWW
Department:	Chemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To design and synthesize a new class of photochromic phenanthroline molecules with interesting optical memory and recording properties, which may possess the capability to function as potential coordinating ligands for the formation of zinc complexes.

List of Research Outputs

Chong H.F., Lam C.F., Ko C.C. and Yam V.W.W., Synthesis, characterization and luminescence studies of trinuclear rhenium-cobalt mixed-metal alkynyl complexes containing a tetrahedral Co₂C₂ cluster unit¹, Journal of Cluster Science. 2004, 15(3): 301-314.

Ko C.C., Wu L., Zhu N. and Yam V.W.W., Synthesis, photochromic and luminescence switching properties of photochromic rhenium(I) complexes, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Dr. Chi Chiu Ko). 2004, 0-17.

Lu X., Tang H.S., Ko C.C., Wong K.Y., Zhu N. and Yam V.W.W., Anion-assisted trans-cis isomerization of palladium(II) phosphine complexes containing acetanilide functionalities through hydrogen bonding interactions, Chemical Communications. 2005, 1572-1574.

Tang H.S., Lu X., Ko C.C., Wong J.K.Y. and Yam V.W.W., First Observation of Ion-Induced Trans-Cis Isomerization of Palladium(II) Phosphine Complex Containing Various Receptor Sites, The XX IUPAC Symposium on Photochemistry, Granada, Spain (Poster presented by Miss Hau-San Tang). 2004.

Tang H.S., Lu X., Ko C.C. and Yam V.W.W., Synthesis, luminescence and ion-induced trans-cis isomerization of palladium(II) phosphine complexes containing various receptor sites, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Miss Hau San Tang). 2004, P-56.

Yam V.W.W., Ko C.C. and Zhu N., Photochromic and luminescence switching properties of a versatile diarylethene-containing 1, 10-phenanthroline ligand and its rhenium(I) complex, Journal of the American Chemical Society. 2004, 126(40): 12734-12735.

Researcher : Ko YY

List of Research Outputs

Li S., Zhang X., Ko Y.Y. and Chiu P., Application of the rhodium-catalyzed carbene cyclization cycloaddition cascade to the synthesis of natural products, International Symposium on Catalysis and Fine Chemicals 2004(C&FC 2004) - Poster Presentation, Hong Kong Polytechnic University, Dec 12 -15. 2004, P-122.

Researcher : Kwan MF

List of Research Outputs

Li F., Li H., Hu L., Kwan M.F., Chen G., He Q. and Sun H., Structure, assembly, and topology of the G185R mutant of the fourth transmembrane domain of divalent metal transporter, Journal of the American Chemical Society. 2005, 127(5): 1414-1423.

Li H., Li F., Kwan M.F., He Q. and Sun H., NMR structres and orientation of the fourth transmembrane domain of the rat divalent metal transporter (DMT1) with G185D mutation in SDS micelles, Biopolymers. 2005, 77: 173-183.

Researcher : Kwok CC

List of Research Outputs

Kwok C.C., Yu S.C., Sham I.H.T. and Che C.M., Self-aggregated phosphorescent platinum(II) polymeric material from modified poly(4-vinylpyridine), Chemical Communications. 2004, 2512-2513.

Kwok C.C., Yu S.C., Sham I.H.T. and Che C.M., Self-assembled zinc(II) Schiff base polymers for applications in polymer light-emitting devices, Chemical Communications. 2004, 2758-2759.

Kwok C.C., Ngai H.M.Y., Chan J.S.C., Sham I.H.T., Che C.M. and Zhu N., [(O^N^N)PtX] Complexes as a new class of light-emitting materials for electrophosphorescent devices, Inorganic Chemistry. 2005, 44: 4442-4444.

Researcher : Kwok WM

Project Title:	Ultrafast time-resolved transient absorption and resonance raman spectroscopic investigations of the photochemistry of selected chlorinated and brominated compounds
Investigator(s):	Kwok WM, Phillips DL
Department:	Chemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To use ultrafast time-resolved spectroscopy techniques to investigate the photochemistry of selected halogenated compounds in water solvated environments.

List of Research Outputs

Chan P.Y., Kwok W.M., Lam S.K., Chiu P. and Phillips D.L., Time-resolved resonance raman observation of the 2-fluorenylnitrenium ion reaction with guanosine to form a C8 intermediate, Journal of the American Chemical Society. 2005, 127: 8246-8247.

Chan W.S., Ma C., Kwok W.M. and Phillips D.L., Time-resolved resonance raman and density functional theory study of hydrogen-bonding effects on the triplet state of p-methoxyacetophenone, Journal of Physical Chemistry A. 2005, 109(15): 3454-3469.

Guan X., Du Y., Li Y., Kwok W.M. and Phillips D.L., Comparison of the dehalogenation of polyhalomethanes and production of strong acids in aqueous and salt (NaCI) water environments: ultraviolet photolysis of CH₂I₂, Journal of Chemical Physics. 2004, 121(17): 8399-8409.

Guan X., Lin X., Kwok W.M., Du Y., Li Y., Zhao C., Wang D. and Phillips D.L., Ultraviolet photolysis of CH₂I₂ in ,methanol: O-H insertion and HI elimination reactions to form a dimethoxymethane product, Journal of Physical Chemistry A. 2005, 109(6): 1247-1256.

Kwok W.M., Chan P.Y. and Phillips D.L., Direct observation of the 2-fluoenylnitrene and 4-methoxyphenylnitrene reactions with water using picosecond kerr-gated time-resolved resonance raman spectroscopy, Journal of Physical Chemistry B. 2004, 108: 19068-19075.

Kwok W.M., Chan P.Y. and Phillips D.L., Direct observation of the 4-Methoxyphenylnitrene intersystem crossing from S₁ to T₁ using picosecond kerr-gated time-resolved resonance raman spectroscopy, Journal of Physical Chemistry A. 2005, 109(10): 2394-2400.

Leung Y.H., Kwok W.M., Djurisic A., Phillips D.L. and Chan W.K., Time-resolved study of stimulated emission in ZnO tetrapod nanowires, Nanotechnology. Bristol, IOP Publishing Limited, 2005, 16: 579-582.

Lin X., Guan X., Kwok W.M., Zhao C., Du Y., Li Y. and Phillips D.L., Water-catalyzed O-H insertion/HI elimination reactions of isodihalomethanes (CH₂X-I, where x=CI,Br, I) with water and the dehalogenation of dihalomethanes in water-solvated environments, Journal of Physical Chemistry A. 2005, 109(6): 981-998.

Ma C., Zuo P., Kwok W.M., Chan W.S., Kan T.W., Toy P.H. and Phillips D.L., Time-resolved resonance raman study of the triplet states of p-hydroxyacetophenone and the p-hydroxyphenacyl diethyl phosphate phototrigger compound, Journal of Organic Chemistry. 2004, 69(20): 6641-6657.

Ma C., Kwok W.M., Chan W.S., Zuo P., Kan T.W., Toy P.H. and Phillips D.L., Ultrafast time-resolved study of photophysical processes involved in the photodeprotection of p-Hydroxyphenacyl caged phototrigger compounds, Journal of the American Chemical Society. 2005, 127(5): 1463-1472.

Phillips D.L., Kwok W.M., Zhao C., Guan X., Du Y., Li Y. and Wang D., Water assisted dehalogenation reactions of selected isopolyhalomethanes, halomethanols and haloformaldehydes, Abstract of 229^th ACS National Meeting, San Diego, California, U.S.A., March 13 - March 17, 2005. Phys. 2005.

Wong K.L., Kwok W.M., Wong W.T., Phillips D.L. and Cheah K.W., Green and red three-photon upconversion from polymeric lanthanide(III) complexes, Angewandte Chemie International Edition. 2004, 43(35): 4659-4662.

Wong K.L., Law G.L., Kwok W.M., Wong W.T. and Phillips D.L., Simultaneous observation of green multiphoton upconversion and red and blue NLO processes from polymeric terbium(III) complexes, Angewandte Chemie International Edition. 2005, 44: 3436-3439.

Zhao C., Lin X., Kwok W.M., Guan X., Du Y., Wang D., Hung K.F. and Phillips D.L., Water-catalyzed dehalogenation reactions of the isomer of CBr₄ and its reaction products and a comparison to analogous reactions of the isomers of d- and trihalomethanes, Chemistry - A European Journal. 2005, 11(4): 1093-1108.

Researcher : Lai PW

List of Research Outputs

Luo L., Lai P.W., Wong K.L., Wong W.T., Li K.F. and Cheah K.W., Green upconversion fluorescence in terbium coordination complexes, Chemical Physics Letters. 2004, 398: 372-376.

Researcher : Lai SW

Project Title:	Photoluminescent platinum(II) materials for sensory applications
Investigator(s):	Lai SW
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2005

Abstract:

refer to hard copy proposal

List of Research Outputs

Lai S.W., Hou Y., Che C.M., Pang H.L., Wong K.Y., Chang C.K. and Zhu N., Electronic Spectroscopy, Photophysical Properties, and Emission Quenching Studies of an Oxidatively Robust Perfluorinated Platinum Porphyrin, XX IUPAC Symposium on Photochemistry, Granada, Spain, 17-22 July. 2004.

Lai S.W., Hou Y., Che C.M., Peng H.L., Wong K.Y., Chang C.K. and Zhu N., Electronic spectroscopy, photophysical properties, and emission quenching studies of an oxidatively robust perfluorinated platinum porphyrin, 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), The University of Hong Kong, Hong Kong, P. R. China, 4-9 July. 2004.

Lai S.W. and Che C.M., Luminescent cyclometalated diimine platinum(II) complexes: Photophysical studies and applications, Topics in Current Chemistry. 2004, 241: 27-63.

Lin Y., Lai S.W., Che C.M., Fu W., Zhou Z.Y. and Zhu N., Structural variations and spectroscopic properties of luminescent mono-and multinuclear silver(I) and copper(I) complexes bearing phosphine and cyanide ligands, Inorganic Chemistry. 2005, 44: 1511-1524.

Wong W.W.H., Curiel D., Lai S.W., Drew M.G.B. and Beer P.D., Ditopic redox-active polyferrocenyl zinc(II) dithiocarbamate macrocyclic receptors: synthesis, coordination and electrochemical recognition properties, Dalton Transactions. 2005, 774-781.

Researcher : Lam CF

List of Research Outputs

Chong H.F., Lam C.F., Yam V.W.W., Zhu N., Cheung K.K., Fathallah S., Costuas K. and Halet J.F., Luminescent heterometallic branched alkynyl complexes of rhenium(I) - palladium(II): potential building blocks for heterometallic metallodendrimers, Organometallics. 2004, 23(21): 4924-4933.

Chong H.F., Lam C.F., Ko C.C. and Yam V.W.W., Synthesis, characterization and luminescence studies of trinuclear rhenium-cobalt mixed-metal alkynyl complexes containing a tetrahedral Co₂C₂ cluster unit¹, Journal of Cluster Science. 2004, 15(3): 301-314.

Lam C.F., Wong M.C., Zhu N., Yam V.W.W., Roué S., Lapinte C., Fathallah S., Costuas K., Kahlal S. and Halet J.F., Electro-swithchable photoluminescence of rhenium-iron mixed-metal alkynyl complexes, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Miss Sally Chan Fung Lam). 2004, P-31.

Lam C.F., Chong H.F., Cheung K.K. and Yam V.W.W., Luminescent rhenium(I) complexes with linear and hyperbranched alkynyl ligands, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Miss Sally Chan Fung Lam). 2004, P-30.

Researcher : Lam CM

List of Research Outputs

Lo W.Y., Lam C.M., Zhu N. and Yam V.W.W., Synthesis and luminescence behaviour of mixed-metal rhenium(I)-copper(I) and -silver(I) alkynyl complexes, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Miss Wing Yin Lo). 2004, P-39.

Researcher : Lam NW

List of Research Outputs

Chu I.K., Lam N.W. and Siu S.O., Facile generation of tripeptide radical cations in Vacuo via intramolecular electron transfer in cu II tripeptide complexes containing sterically encumbered terpyridine ligands, Journal of the American Society for Mass Spectrometry. 2005, 16: 763-771.

Lam N.W., Siu S.O. and Chu I.K., Efficient formation of peptide radical cations in vacuo by electron transfer of Cu^II(Amine)peptide complexes, Poster Presentation in 12th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, April 23, 2005. Hong Kong, Poster No: AE-22.

Lam N.W., Siu S.O. and Chu I.K., Efficient formation of peptide radical cations in vacuo by electron transfer of Cu^II(Amine)peptide complexes, Poster Presentation in Proceedings of the 53rd ASMS Conference on Mass Spectrometry and Allied Topics, San Antonio, Texas, U.S.A., June 5-9, 2005.

Lie Ken Jie M.S.F. and Lam N.W., Reaction of Mono-epoxidized Conjugated Linoleic Acid Ester with Boron Trifluoride Etherate Complex , Lipids. 2004, 39: 583-587.

Yu K.Y., Lam N.W., Lo C.S.C. and Chu I.K., Qualitative and quantitative analysis of flavonoid metabolites in sorghum by liquid chromatograph tandem mass spectrometry, Poster Presentation in 12th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, April 23, 2005. Hong Kong, Poster No: AE-21.

Researcher : Lam SK

List of Research Outputs

Chan P.Y., Kwok W.M., Lam S.K., Chiu P. and Phillips D.L., Time-resolved resonance raman observation of the 2-fluorenylnitrenium ion reaction with guanosine to form a C8 intermediate, Journal of the American Chemical Society. 2005, 127: 8246-8247.

Lam S.K. and Chiu P., Studies toward the synthesis of linearol, The 15^th International Conference on Organic Synthesis, Nagoya, Japan, August 1-6, 2004. 3-E-19.

Lam S.K. and Chiu P., Studies toward the synthesis of linearol, The 8^th International Symposium for Chinese Organic Chemists, The Chinese University of Hong Kong, Dec 12-19, 2004. PP-71.

Researcher : Lam SML

List of Research Outputs

Tse C.W., Lam S.M.L., Man K.K.Y., Wong W.T. and Chan W.K., Synthesis and characterization of random and block copolymers with pendant rhenium diimine complexes by controlled radical polymerization, Journal of Polymer Science: Part A: Polymer Chemistry. 2005, 43: 1292-1308.

Researcher : Lau CY

List of Research Outputs

Lau C.Y., He S., Chiu P. and Toy P.H., Polystyrene-supported triphenylarsine reagents and their use in Suzuki cross-coupling reactions, Journal of Combinatorial Chemistry. 2004, 6(6): 955-960.

Lau C.Y. and Chiu P., Polystyrene-supported triphenylarsine reagents and their use in Suzuki cross-coupling reactions, The 8th International Symposium of Chinese Organic Chemists, The Chinese University of Hong Kong, Dec 12-19, 2004. PP-75.

Researcher : Law GL

List of Research Outputs

Law G.L., Wong K.L., Zhou X.J., Wong W.T. and Tanner P.A., Crystal structure and luminescence of lanthanide monodentate complexes [Ln(C₄N₄H₆O)₂(H₂O)₆]Cl₃ and [Ln(C₄N₄H₆O)₂(H₂O)₃(NO₃)₃](Ln=Tb or Eu), Inorganic Chemistry. 2005, 44: 4142-4144.

Li C., Law G.L. and Wong W.T., Luminescent Tb³⁺ complex with pendant crown ether showing dual-component recognition of H⁺ and K⁺ at multiple pH windows, Organic Letters. 2004, 6(26): 4841-4844.

Wong K.L., Law G.L., Kwok W.M., Wong W.T. and Phillips D.L., Simultaneous observation of green multiphoton upconversion and red and blue NLO processes from polymeric terbium(III) complexes, Angewandte Chemie International Edition. 2005, 44: 3436-3439.

Researcher : Law KL

List of Research Outputs

Law K.L. and Yang D., Photo-induced phenylseleno group transfer radical cyclization reactions for the formation of spirolactams, The 12^th Symposium on Chemistry Postgraduate Research in Hong Kong, The City University of Hong Kong, April 23,2005.

Law K.L. and Yang D., Photo-induced phenylseleno group transfer radical cyclization reactions for the formation of spirolactams, The 8^th International Symposium for Chinese Organic Chemists and the 5^th International Symposium for Chinese Organic Chemists,The Chinese University of Hong Kong, Hong Kong,December 19-22,2004.

Researcher : Lee OY

List of Research Outputs

Lee O.Y. and Yang D., Synthesis of heterocycles via phenylseleno group transfer radical cyclization reactions, The 12^th Symposium on Chemistry Postgraduate Research in Hong Kong, April 23,2005.

Lee O.Y. and Yang D., Synthesis of heterocycles via phenylseleno group transfer radical cyclization reactions, The 8^th International Symposium for Chinese Organic Chemists and the 5^th International Symposium for Chinese Inorganic Chemists, The Chinese University of Hong Kong, Hong Kong, December 19-22,2004 . 2004.

Yang D., Yip K.T.P., Li J. and Lee O.Y., Ytterbium triflate and palladium(II)-catalyzed oxidative cyclization of alkenyl b-keto amdes with molecular oxygen. An approach to heterocycles, The IUPAC 15^th International Conference on Organic Synthesis,Aug 1-6,2004,Nagoya, Japan. 2004.

Researcher : Leung KY

List of Research Outputs

Huang J.S., Leung K.Y., Zhou Z.Y., Zhu N. and Che C.M., Tuning the Reactivity of Dioxoruthenium(VI) Porphyrins toward anArylimine by Altering Porphyrin Substituents, Inorganic Chemistry. 2005, 44: 3780-3788.

Mao Z., Huang J.S., Che C.M., Zhu N., Leung K.Y. and Zhou Z.Y., Unexpected reactivities of Cu₂(diphosphine)₂ complexes in alcohol: isolation, x-ray crystal structure, and photoluminescent properties of a remarkably stable [Cu₃(diphosphine)₃(m₃ - H)]²⁺ hydride complex, Journal of the American Chemical Society. 2005, 127(13): 4562-4563.

Yu M.S., Leung K.Y., Lai S.W., Che C.M., Zee S.S.Y., So K.F., Yuen W.H. and Chang R.C.C., Neuroprotective effects of anti-aging oriental medicine Lycium barbarum against bamyloid peptide neurotoxicity, Experimental Gerontology. 2005, 40: 716-727.

Researcher : Leung KY

List of Research Outputs

Researcher : Leung LT

List of Research Outputs

Leung L.T., Leung S.K. and Chiu P., Hydrostannation of alkynes catalyzed by Stryker's reagent, The 8^th International Symposium for Chinese Organic Chemists, The Chinese University of Hong Kong, Dec 12-19, 2004. 2004, PP-80.

Researcher : Leung SK

List of Research Outputs

Chiu P. and Leung S.K., Stoichiometric and catalytic reductive aldol cyclizations of alkynediones induced by Stryker's reagent, Chemical Communications. 2004, 2004(20): 2308-2309.

Leung L.T., Leung S.K. and Chiu P., Hydrostannation of alkynes catalyzed by Stryker's reagent, The 8^th International Symposium for Chinese Organic Chemists, The Chinese University of Hong Kong, Dec 12-19, 2004. 2004, PP-80.

Leung S.K., I.novel reactions of oxabicyclic compounds II.reductive aldol cyclization of alkynones and alkynoates(PhD). 2005.

Leung S.K. and Chiu P., Metal-catalyzed cyclopropanation on the 8-oxabicyclo[3.2.1]oct-6-ene template, Tetrahedron Letters. 2005, 46(15): 2709-2712.

Researcher : Leung SKY

List of Research Outputs

Chang R.C.C., Yu M.S., Leung S.K.Y., Lai S.W., Che C.M., Zee S.S.Y., So K.F. and Yuen W.H., Neuroprotective effects of anti-aging Chinese Medicine Lycium barbarum against b-amyloid peptide neurotoxicity. (Best Poster Prize in Poster Session 2), International Congress on Complementary and Alternative Medicines (ICCAM) 2005, 26-28 February 2005, Singapore. 2005, 145.

Researcher : Leung WH

List of Research Outputs

Leung W.H., Ma T. and Cheung A.S.C., Cavity ring down absorption spectroscopy of the B²å⁺-X²å⁺ transition of YO, Journal of Molecular Spectroscopy. 2005, 229: 108-114.

Ma T., Li L., Leung W.H., Wong M.Y. and Cheung A.S.C., Cavity ring-down laser absorption spectroscopy of yttrium and nickel monoiodides, 60th Ohio State University International Symposium on Molecular Spectroscopy, U.S.A., June 20-24. 2005, FB05.

Ye J., Leung W.H. and Cheung A.S.C., Laser spectroscopy of nickel monobromide, 60th Ohio State University International Symposium on Molecular Spectroscopy, U.S.A., June 20-24. 2005, FB04.

Researcher : Li B

List of Research Outputs

Yang D., Zhang Y., Li B. and Zhang D., Synthesis of chiral b³-Aminoxy peptides, Journal of Organic Chemistry. 2004, 69: 7577-7581.

Researcher : Li C

List of Research Outputs

Li C., Lanthanide complexes for magnetic resonance imaging(mri)contrast agents and luminescent sensors(PhD). 2004.

Li C., Law G.L. and Wong W.T., Luminescent Tb³⁺ complex with pendant crown ether showing dual-component recognition of H⁺ and K⁺ at multiple pH windows, Organic Letters. 2004, 6(26): 4841-4844.

Li C. and Wong W.T., Luminescent heptadentate Tb³⁺ complex with pendant aza-15-crown-5 showing recognition of lactate and salicylate in aqueous solution, Tetrahedron Letters. 2004, 45: 6055-6058.

Li C. and Yang D., Total synthesis of 5-demethoxyfumagillol, The 12^th Symposium on Chemistry Postgraduate Research in Hong Kong, The City University of Hong Kong, April 23,2005.

Researcher : Li CK

List of Research Outputs

Li C.K., Lu X., Wong M.C., Chan C.L., Zhu N. and Yam V.W.W., Molecular design of luminescence ion probes for various cations based on weak gold(I)...gold(I) interactions in dinuclear gold(I) complexes, Inorganic Chemistry. 2004, 43(23): 7421-7430.

Researcher : Li F

List of Research Outputs

Li F., Li H., Hu L., Kwan M.F., Chen G., He Q. and Sun H., Structure, assembly, and topology of the G185R mutant of the fourth transmembrane domain of divalent metal transporter, Journal of the American Chemical Society. 2005, 127(5): 1414-1423.

Li H., Li F., Kwan M.F., He Q. and Sun H., NMR structres and orientation of the fourth transmembrane domain of the rat divalent metal transporter (DMT1) with G185D mutation in SDS micelles, Biopolymers. 2005, 77: 173-183.

Ye K., Wang J., Sun H., Liu Y., Mu Z., Li F., Jiang S., Zhang J., Zhang H., Wang Y. and Che C.M., Supramolecular structures and assembly and luminescent properties of quinacridone derivatives, Journal of Physical Chemistry B. 2005, 109: 8008-8016.

Zu Y. and Li F., NADH oxidation at fluorosurfactant-covered metal electrodes , 2004 Joint International Meeting (206th Meeting of The Electrochemical Society and 2004 Fall Meeting of The Electrochemical Society of Japan). 2004, 2209.

Researcher : Li F

List of Research Outputs

Researcher : Li H

List of Research Outputs

Li F., Li H., Hu L., Kwan M.F., Chen G., He Q. and Sun H., Structure, assembly, and topology of the G185R mutant of the fourth transmembrane domain of divalent metal transporter, Journal of the American Chemical Society. 2005, 127(5): 1414-1423.

Li H., Li F., Kwan M.F., He Q. and Sun H., NMR structres and orientation of the fourth transmembrane domain of the rat divalent metal transporter (DMT1) with G185D mutation in SDS micelles, Biopolymers. 2005, 77: 173-183.

Researcher : Li HY

List of Research Outputs

Li H.Y., Fung K.L., Ching Y.P., Ng I.O.L., Chung S.S.M., Sze K.H., Ko B.C.B. and Sun H., Structural study of the SAM domain of the deleted in liver cancer 2 (DLC2), Chemistry Symposium of Hong Kong, March 2005.

Researcher : Li J

List of Research Outputs

Gao Q., Zheng B., Li J. and Yang D., Ni(II)-catalyzed conia-ene reaction of 1,3-dicarbonyl compounds with alkynes, Organic Letters. 2005, 7(11): 2185-2188.

Yang D., Yip K.T.P., Li J. and Lee O.Y., Ytterbium triflate and palladium(II)-catalyzed oxidative cyclization of alkenyl b-keto amdes with molecular oxygen. An approach to heterocycles, The IUPAC 15^th International Conference on Organic Synthesis,Aug 1-6,2004,Nagoya, Japan. 2004.

Researcher : Li L

List of Research Outputs

Ma T., Li L., Leung W.H., Wong M.Y. and Cheung A.S.C., Cavity ring-down laser absorption spectroscopy of yttrium and nickel monoiodides, 60th Ohio State University International Symposium on Molecular Spectroscopy, U.S.A., June 20-24. 2005, FB05.

Researcher : Li S

List of Research Outputs

Li S., Zhang X., Ko Y.Y. and Chiu P., Application of the rhodium-catalyzed carbene cyclization cycloaddition cascade to the synthesis of natural products, International Symposium on Catalysis and Fine Chemicals 2004(C&FC 2004) - Poster Presentation, Hong Kong Polytechnic University, Dec 12 -15. 2004, P-122.

Li S. and Chiu P., Studies toward the total synthesis of guanacastepene A, The 8^th International Symposium of Chinese Organic Chemits, The Chinese University of Hong Kong, Dec 12-19,2004. PP-85.

Researcher : Li W

List of Research Outputs

Li W., Peptides of alpha-aminoxy acids:novel secondary structures and applications as selective chloride receptors(PhD). 2004.

Wong M.C., Li W., Cheung K.K. and Yam V.W.W., Synthesis, photophysics, electrochemistry and metal ion-binding studies of rhenium(I) complexes with crown ether pendants:selective and specific binding properties for various metal ions, New Journal of Chemistry. 2005, 29: 165-172.

Researcher : Li W

List of Research Outputs

Li W., Peptides of alpha-aminoxy acids:novel secondary structures and applications as selective chloride receptors(PhD). 2004.

Researcher : Li X

List of Research Outputs

Li X., Fan Y.F. and Yang D., Enantioselective carboxylate recognition: A novel receptor derived from a-Aminoxy acids functions as a chiral shift reagent, The 12^th Symposium on Chemistry Postgraduate Research in Hong Kong, The City University of Hong Kong - Oral Presentation, April 23, 2005.

Yang D., Li X., Sha Y. and Wu Y.D., A cyclic hexapeptide comprising alternating a-aminioxy and a-amino acids is a selective chloride ion receptor, Chemistry - A European Journal. 2005, 11: 3005-3009.

Yang D., Li X., Fan Y.F. and Zhang D.W., Enantioselective recognition of carboxylates: A receptor derived from a-aminoxy acids functions as a chiral shift reagent for carboxylic acids, Journal of the American Chemical Society. 2005, 127: 7996-7997.

Researcher : Li X

List of Research Outputs

Researcher : Li Y

List of Research Outputs

Guan X., Du Y., Li Y., Kwok W.M. and Phillips D.L., Comparison of the dehalogenation of polyhalomethanes and production of strong acids in aqueous and salt (NaCI) water environments: ultraviolet photolysis of CH₂I₂, Journal of Chemical Physics. 2004, 121(17): 8399-8409.

Guan X., Lin X., Kwok W.M., Du Y., Li Y., Zhao C., Wang D. and Phillips D.L., Ultraviolet photolysis of CH₂I₂ in ,methanol: O-H insertion and HI elimination reactions to form a dimethoxymethane product, Journal of Physical Chemistry A. 2005, 109(6): 1247-1256.

Li Y., Huang J.S., Xu G.B., Zhu N., Zhou Z.Y., Che C.M. and Wong K.Y., Spectral, structural, and electrochemical properties of ruthenium porphyrin diaryl and aryl(alkoxycarbonyl) carbene complexes: influence of carbene substituents, porphyrin substituents, and trans-axial ligands, Chemistry A European Journal. 2004, 10: 3486-3502.

Lin X., Guan X., Kwok W.M., Zhao C., Du Y., Li Y. and Phillips D.L., Water-catalyzed O-H insertion/HI elimination reactions of isodihalomethanes (CH₂X-I, where x=CI,Br, I) with water and the dehalogenation of dihalomethanes in water-solvated environments, Journal of Physical Chemistry A. 2005, 109(6): 981-998.

Phillips D.L., Kwok W.M., Zhao C., Guan X., Du Y., Li Y. and Wang D., Water assisted dehalogenation reactions of selected isopolyhalomethanes, halomethanols and haloformaldehydes, Abstract of 229^th ACS National Meeting, San Diego, California, U.S.A., March 13 - March 17, 2005. Phys. 2005.

Zheng X.M., Li Y. and Phillips D.L., Resonance raman study of the short-time photodissociation dynamics of the A-band absorption of cycloproplyI iodide in cyclohexane solution, Journal of Physical Chemistry A. 2004, 108: 8032-8039.

Researcher : Li Y

List of Research Outputs

Researcher : Liang J

List of Research Outputs

Zhang J., Liang J., Sun X., Zhou H., Zhu N., Zhou Z.Y., Chan P.W.H. and Che C.M., Chiral osmium complexes with sterically bulky schiff-base lignads. Crystal structures of Os(IV) derivatives and the reactivity and catalytic cyclopropanation of alkenes with EDA, Inorganic Chemistry. 2005, 44: 3942-3954.

Researcher : Lie Ken Jie MSF

List of Research Outputs

Lie Ken Jie M.S.F., Synthesis of chloro-and fluoro tri-substituted C₁₈ furan fatty esters, 95th Annual Meeting of the American Oil Chemists' Society - Cincinatti . 2004.

Mishra G., Ramalingam S., Lie Ken Jie M.S.F. and Chye M.L., Characterization of a mutant in Arabidopsis ACBP2, In CD and e-book "Proceedings of the 16th International Symposium on Plant Lipids", Budapest, Hungary. www.mete.mtesz.hu/pls P3-4 p.1-3. 2004, On-line Publication.

Researcher : Lin B

List of Research Outputs

Qin J., Ye N., Yu L., Fung Y.S. and Lin B., Simultaneous determination of reactive oxygen species and reduced glutathione in apoptotic leukaemia cells by capillary electrophoresis, Abstract of 5^th Asia-Pacific International Symposium on Microscale Separation and Analysis (APCE2004), Seoul, South Korea, Dec 5-8, 2004, P26. 2004, p92.

Researcher : Lin MC

Project Title:	Ethanol regulated gene transcription: identification of "ethanol-responsive-cis-element" in the promoter region of human MTP gene
Investigator(s):	Lin MC, Jin D
Department:	Institute of Molecular Biology
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2000

Abstract:

To identify and characterize the location, consensus sequences, and functional significance of the ERE in the promoter region of the human MTP gene; to isolate and characterize the transcription factor(s) that bind to this ERE; to identify other candidate genes that are regulated bia this ERE by computer-aided analysis; to validate the functional significance of this ERE by testing the effects of low concentrations of ethanol on the promoter activities of the candidate genes in vitro in humna cell lines; to determine the effect of a long term low/moderate ethanol consumption on gene expression profiles in vivo in rats; to determine the effect of ethanol consumption on gene expression profiles in Xenopus (African frogs) embryo.

Project Title:	Basic research on systemic damage in early stage and wound-healing after severe trauma
Investigator(s):	Lin MC
Department:	Institute of Molecular Biology
Source(s) of Funding:	Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:	04/2001

Abstract:

To study basic research on systemic damage in early stage and wound-healing after severe trauma.

Project Title:	Developmental function, molecular target, and transcriptional regulation of the cold-inducible RNA binding protein
Investigator(s):	Lin MC
Department:	Institute of Molecular Biology
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	12/2001

Abstract:

To elucidate the function of XCIRP-1 in Xenopus embryonic neural development; to discover the specific down-stream target RNAs of the DCIRP-1 protein in order to understand the molecular mechanisms of the XCIRP-1 actions; to clone the promoter of human CIRP gene, characterize the transcriptional regulation, and investigate the cold- and heat-induced regulation of hCIRP gene expression in human brain- and liver-derived cell lines.

Project Title:	Basic research on the mechanism of aging and the prevention of geriatric disease
Investigator(s):	Lin MC
Department:	Institute of Molecular Biology
Source(s) of Funding:	Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:	12/2001

Abstract:

To study the mechanism of aging and the prevention of geriatric disease.

Project Title:	Characterization of a novel cell cycle related kinase in glioblastoma
Investigator(s):	Lin MC, Leung SY, Ching YP
Department:	Institute of Molecular Biology
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	12/2002

Abstract:

The project aims at characterizing the role of cell cycle related kinase (CCRK) in cell cycle control, apoptosis, cell division and cell proliferation. Potential tumorigenic function of CCRK in human glioblastoma, fibroblast cell lines, and nude mice xenograft will also be investigated.

Project Title:	Isolation and characterization of the silkworm factors that enhance the intestinal absorption/transport of orally delivered therapeutic proteins
Investigator(s):	Lin MC
Department:	Institute of Molecular Biology
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	05/2003
Completion Date:	10/2004

Abstract:

To isolate and characterize silkworm factors responsible for enhancing the intestinal absorption / transport of orally delivered protein drugs.

Project Title:	Cancer gene therapy using a novel anti-cancer polypeptide hTERTC27 delivered by a novel AAV and Adenovirus Cocktail vector system
Investigator(s):	Lin MC, Wong BCY, Kung H, Peng Y
Department:	Institute of Molecular Biology
Source(s) of Funding:	Innovation and Technology Support Programme
Start Date:	06/2003

Abstract:

To optimize our innovative, novel and patented hTERTC27 cancer gene therapy and the AAV/Adv cocktail vector technologies developed in our laboratory; to establish patented stable cell line and platforms for the large scale production of AAV-hTERTC27 and Adv-hTERTC27; to carry out, using the above, in pre-clinical study for treating solid tumors.

Project Title:	Molecular basis of alcohol-induced birth defects, the critical role of Pax 6
Investigator(s):	Lin MC, Wong BCY, Yang JY, Peng Y
Department:	Institute of Molecular Biology
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	09/2003

Abstract:

To elucidate the signaling pathways leading to alcohol-mediated inhibition of Pax6 expression and to identify the targets downstream of Pax6 responsible for microcephaly. We are particularly interested in the involvements of the PI3 kinase pathways and the reactive oxygen species and reactive nitrogen species; to investigate the molecular mechanisms for alcohol-induced growth retardation, in particular its relationship with gut development; to study alcohol induced eye deformation; to screen for agents that protect against alcohol induced birth defects.

Project Title:	Molecular basis of alcohol-induced birth defects, the critical role of Pax 6
Investigator(s):	Lin MC, Wong BCY, Yang JY, Peng Y
Department:	Institute of Molecular Biology
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2003

Abstract:

Project Title:	Molecular basis for the telomere dysfunction and anti-tumor activities of a C-terminal polypeptide of human telomerase reverse transcriptase (hTERTC27)
Investigator(s):	Lin MC, Wong BCY
Department:	Institute of Molecular Biology
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	12/2003

Abstract:

To identify the proteins which interact with hTERTC27; to charaterize the anti-tumor activity of hTERTC27 in vitro using varied TERT positive and TERT negative cell lines and stem cells; to test the efficacy of hTERTC27 cancer gene therapy against glioblastoma in vivo in nude mice xenograft using an Adeno Associated Virus and Adenovirus-based gene delivery system.

Project Title:	Development of a novel insect cell system for large scale recombinant AAV production
Investigator(s):	Lin MC, He ML
Department:	Institute of Molecular Biology
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	01/2004
Completion Date:	01/2005

Abstract:

To develop a robust, cost-effective, large-scale system for the preparation of high-titer, high-purity recombinant AAV vector sing the baculovirus and insect Sf9 cells.

Project Title:	Gene therapy for the treatment of HBV infection, HBV-induced liver cancer
Investigator(s):	Lin MC, Zheng B, Yuen KY, Kung H
Department:	Institute of Molecular Biology
Source(s) of Funding:	Innovation and Technology Support Programme
Start Date:	07/2004

Abstract:

To develop an innovative and effective gene therapies to treat HBV infection and HCC.

Project Title:	Characterization of the HNF-1 element as a novel Insulin Negative Response cis-Element (INRE) and its implication in diabetes
Investigator(s):	Lin MC
Department:	Institute of Molecular Biology
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2004

Abstract:

Refer to hard copy

Project Title:	Development of Novel AAV based anti-angiogenesis gene therapy for the treatment of liver cancer
Investigator(s):	Lin MC, Fan ST, Wong BCY, Ng SM, He ML, Gan R.B., Kung H
Department:	Institute of Molecular Biology
Source(s) of Funding:	Innovation and Technology Support Programme
Start Date:	08/2004

Abstract:

To develop an innovative and effective gene therapies to treat hepatocellular carcinoma (HCC).

Project Title:	Cancer gene therapy using a novel anti-cancer polypeptide hTERTC27 delivered by a novel AAV and Adenovirus Cocktail vector system
Investigator(s):	Lin MC, Kung H, Wong BCY
Department:	Institute of Molecular Biology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	09/2004
Completion Date:	07/2005

Abstract:

Project Title:	Characterizing the role of P13K signaling cascade in Xenopus neural induction
Investigator(s):	Lin MC
Department:	Institute of Molecular Biology
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

List of Research Outputs

Cheung Y.T., He Q., Li M., Leung S.Y., Chiu J., Lin M.C. and Kung H., Characterization of human cell cycle related kinase in glioblastoma carcinogenesis by a proteomic study, Advances in Proteomics in Cancer Research, Florida, USA, October 1,2004.

Researcher : Lin X

List of Research Outputs

Guan X., Lin X., Kwok W.M., Du Y., Li Y., Zhao C., Wang D. and Phillips D.L., Ultraviolet photolysis of CH₂I₂ in ,methanol: O-H insertion and HI elimination reactions to form a dimethoxymethane product, Journal of Physical Chemistry A. 2005, 109(6): 1247-1256.

Lin X., Zhao C. and Phillips D.L., Ab initio investigation of the O-Y (Y=CH₃, H) insertion/HI elimination reactions of CH₂I-I with CH₃OH and H₂O: comparison of methanol and water catalyzed reactions, Chemical Physics Letters. 2004, 397: 488-494.

Lin X., Zhao C. and Phillips D.L., An ab inition study of the reactions of CH₂X-X (X=C1,Br, I) isopolyhalomethanes with nCH₃OH, Molecular Simulation. 2005, 31(6-7): 483-488.

Lin X., Guan X., Kwok W.M., Zhao C., Du Y., Li Y. and Phillips D.L., Water-catalyzed O-H insertion/HI elimination reactions of isodihalomethanes (CH₂X-I, where x=CI,Br, I) with water and the dehalogenation of dihalomethanes in water-solvated environments, Journal of Physical Chemistry A. 2005, 109(6): 981-998.

Zhao C., Lin X., Kwok W.M., Guan X., Du Y., Wang D., Hung K.F. and Phillips D.L., Water-catalyzed dehalogenation reactions of the isomer of CBr₄ and its reaction products and a comparison to analogous reactions of the isomers of d- and trihalomethanes, Chemistry - A European Journal. 2005, 11(4): 1093-1108.

Researcher : Lin Y

List of Research Outputs

Lin Y., Lai S.W., Che C.M., Fu W., Zhou Z.Y. and Zhu N., Structural variations and spectroscopic properties of luminescent mono-and multinuclear silver(I) and copper(I) complexes bearing phosphine and cyanide ligands, Inorganic Chemistry. 2005, 44: 1511-1524.

Researcher : Liu J

List of Research Outputs

Liu J., Wang H., Cheng S. and Chan G.K.Y., Nafion-polyfurfuryl alcohol nanocomposite membranes for direct methanol fuel cells, Journal of Membrane Science . 2005, 246: 95-101.

Researcher : Liu Y

List of Research Outputs

Liu Y., Wong K.W., Ko C.B., Wong M.K. and Che C.M., Synthesis and cytotoxicity studies of artemisinin derivatives containing lipophilic alkyl carbon chains, Organic Letters. 2005, 7: 1561-1564.

Researcher : Lo WY

List of Research Outputs

Cheng C.C., Lo W.Y., Zhu N. and Yam V.W.W., Luminescent soluble polynuclear gold(I) chalcogenido aggreates-syntheses, characterization and photophysics, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Dr. Eddie Chung Chin Cheng). 2004, P-9.

Lo W.Y., Syntheses, characterization and emission studies of luminescent homo- and heterometallic clusters based on coinage metal alkynyl and chalcogenide core(PhD). 2004.

Lo W.Y., Lam C.M., Zhu N. and Yam V.W.W., Synthesis and luminescence behaviour of mixed-metal rhenium(I)-copper(I) and -silver(I) alkynyl complexes, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Miss Wing Yin Lo). 2004, P-39.

Researcher : Lu X

List of Research Outputs

Li C.K., Lu X., Wong M.C., Chan C.L., Zhu N. and Yam V.W.W., Molecular design of luminescence ion probes for various cations based on weak gold(I)...gold(I) interactions in dinuclear gold(I) complexes, Inorganic Chemistry. 2004, 43(23): 7421-7430.

Lu X., Tang H.S., Ko C.C., Wong K.Y., Zhu N. and Yam V.W.W., Anion-assisted trans-cis isomerization of palladium(II) phosphine complexes containing acetanilide functionalities through hydrogen bonding interactions, Chemical Communications. 2005, 1572-1574.

Tang H.S., Lu X., Ko C.C., Wong J.K.Y. and Yam V.W.W., First Observation of Ion-Induced Trans-Cis Isomerization of Palladium(II) Phosphine Complex Containing Various Receptor Sites, The XX IUPAC Symposium on Photochemistry, Granada, Spain (Poster presented by Miss Hau-San Tang). 2004.

Tang H.S., Lu X., Ko C.C. and Yam V.W.W., Synthesis, luminescence and ion-induced trans-cis isomerization of palladium(II) phosphine complexes containing various receptor sites, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Miss Hau San Tang). 2004, P-56.

Tang W.S., Wong M.C., Lu X., Zhu N. and Yam V.W.W., Functionalized Platinum(II) Alkynyl Complexes as Colorimetric and Luminescence pH Sensors, The XX IUPAC Symposium on Photochemistry, Granada, Spain (Poster presented by Miss Wing-Suen Tang). 2004.

Tang W.S., Wong M.C., Lu X., Zhu N. and Yam V.W.W., Functionalized platinum(II) alkynyl complexes as colorimetric and luminescence _pH and ion sensors, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Miss Wing Suen Tang). 2004, P-57.

Wong M.C., Tang W.S., Lu X., Zhu N. and Yam V.W.W., Functionalized platinum(II) terpyridyl alkynyl complexes as colorimetric and luminescence pH sensors, Inorganic Chemistry. 2005, 44(5): 1492-1498.

Researcher : Luo L

List of Research Outputs

Luo L., Lai P.W., Wong K.L., Wong W.T., Li K.F. and Cheah K.W., Green upconversion fluorescence in terbium coordination complexes, Chemical Physics Letters. 2004, 398: 372-376.

Researcher : Ma C

List of Research Outputs

Chan W.S., Ma C., Kwok W.M. and Phillips D.L., Time-resolved resonance raman and density functional theory study of hydrogen-bonding effects on the triplet state of p-methoxyacetophenone, Journal of Physical Chemistry A. 2005, 109(15): 3454-3469.

Ma C., Zuo P., Kwok W.M., Chan W.S., Kan T.W., Toy P.H. and Phillips D.L., Time-resolved resonance raman study of the triplet states of p-hydroxyacetophenone and the p-hydroxyphenacyl diethyl phosphate phototrigger compound, Journal of Organic Chemistry. 2004, 69(20): 6641-6657.

Ma C., Kwok W.M., Chan W.S., Zuo P., Kan T.W., Toy P.H. and Phillips D.L., Ultrafast time-resolved study of photophysical processes involved in the photodeprotection of p-Hydroxyphenacyl caged phototrigger compounds, Journal of the American Chemical Society. 2005, 127(5): 1463-1472.

Researcher : Ma CC

List of Research Outputs

Ma C.C., Tribological study of carbon nanotube oscillators(PhD). 2004.

Yam C.Y., Ma C.C., Wang X. and Chen G., Electronic structure and charge distribution of potassium iodide intercalated single-walled carbon nanotubes, Applied Physics Letters. 2004, 85(19): 4484-4486.

Researcher : Ma DL

List of Research Outputs

Siu K.M.P., Ma D.L. and Che C.M., Luminescent cyclometalated platinum(II) complexes with amino acid ligands for protein binding, Chemical Communications. 2005, 1025-1027.

Researcher : Ma T

List of Research Outputs

Leung W.H., Ma T. and Cheung A.S.C., Cavity ring down absorption spectroscopy of the B²å⁺-X²å⁺ transition of YO, Journal of Molecular Spectroscopy. 2005, 229: 108-114.

Ma T., Li L., Leung W.H., Wong M.Y. and Cheung A.S.C., Cavity ring-down laser absorption spectroscopy of yttrium and nickel monoiodides, 60th Ohio State University International Symposium on Molecular Spectroscopy, U.S.A., June 20-24. 2005, FB05.

Ma T., Cavity ringdown laser absorption spectroscopy of free radicals(PhD). 2004.

Researcher : Man KKY

List of Research Outputs

Chan W.K., Man K.K.Y., Cheng K.W., Wong H.L. and Djurisic A., Fabrication of organic photovoltaic devices by the layer-by-layer polyelectrolyte deposition method, 2004 Conference on Optoelectronic and Microelectronic Materials and Devices (COMMAD 2004), The University of Queensland, Brisbane, Australia, December 8-10, 2004.

Chan W.K., Man K.K.Y., Wong H.L., Cheng K.W., Tse C.W. and Djurisic A., The use of metal-containing polymers as sensitizers in photovoltaic cells and photodetectors, The 5th Asian Photochemistry Conference (APC-5), Taipei, Taiwan, January 5-10. 2005.

Cheng K.W., Man K.K.Y., Tse C.W., Chan W.K. and Djurisic A., Fabrication of photovoltaic devices incorporated with cadmium sulfide nanoparticles by a multilayer deposition process, Materials Research Society 2004 Fall Meeting, Boston, USA, November 28-December 2, 2004.

Leung Y.H., Djurisic A., Choy W.C.H., Xie M.H., Gao J., Cheah K.W., Man K.K.Y. and Chan W.K., Synthesis and properties of ZnO multipod structures, Journal of Crystal Growth. Amsterdam, Elsevier B.V., 2005, 274: 430-437.

Tse C.W., Lam S.M.L., Man K.K.Y., Wong W.T. and Chan W.K., Synthesis and characterization of random and block copolymers with pendant rhenium diimine complexes by controlled radical polymerization, Journal of Polymer Science: Part A: Polymer Chemistry. 2005, 43: 1292-1308.

Researcher : Man KYK

List of Research Outputs

Chan W.K., Man K.Y.K., Hui C.S. and Wong H.L., The use of metal containing polymers as photo-sensitizing materials, 15th International Symposium on Photophysics and Photochemistry of Coordination Compounds, Hong Kong, July 4-9, 2004.

Man K.Y.K., Synthesis of transition metal containing polymers and fabrication of photonic devices by self assembly method(PhD). 2004.

Wong H.L., Cheng K.W., Man K.Y.K., Kwong C.Y., Chan W.K. and Djurisic A., Fabrication of bulk heterojunction photovoltaic devices using sublimable rhenium diimine complexes as photosensitizers, Proceedings of SPIE. Bellingham, SPIE, 2004, 5520: 168-175.

Researcher : Mao Z

List of Research Outputs

Mao Z., Huang J.S., Che C.M., Zhu N., Leung K.Y. and Zhou Z.Y., Unexpected reactivities of Cu₂(diphosphine)₂ complexes in alcohol: isolation, x-ray crystal structure, and photoluminescent properties of a remarkably stable [Cu₃(diphosphine)₃(m₃ - H)]²⁺ hydride complex, Journal of the American Chemical Society. 2005, 127(13): 4562-4563.

Researcher : Ng FY

List of Research Outputs

Chui S.Y., Ng F.Y. and Che C.M., Structure determination of homoleptic Au^I, Ag^I, and Cu^I Aryl/Alkylethynyl coordination polymers by s-ray powder diffraction, Chemistry - A European Journal. 2005, 11: 1739-1749.

Researcher : Ng KM

List of Research Outputs

Ng K.M., Oral presentation: Quality control of ginseng - HPLC/MS Chemical Fingerprint, Quality Control Working Group Section, Second Meeting of the Consortium for Globalization of Chinese Medicine, Shanghai, July 27-28, 2004. 2004.

Researcher : Ngai HMY

List of Research Outputs

Kwok C.C., Ngai H.M.Y., Chan J.S.C., Sham I.H.T., Che C.M. and Zhu N., [(O^N^N)PtX] Complexes as a new class of light-emitting materials for electrophosphorescent devices, Inorganic Chemistry. 2005, 44: 4442-4444.

Researcher : Ngan TW

List of Research Outputs

Ngan T.W., Design, synthesis and studies of novel photochromic zinc(II) thiolate complexes(MPhil). 2005.

Researcher : Ong SY

List of Research Outputs

Chan P.Y., Ong S.Y., But Y.S. and Phillips D.L., Time-resolved resonance Raman and density functional theory investigation of the 4-biphenylnitrene dimerization reaction, Journal of Raman Spectroscopy. 2004, 35: 887-894.

Researcher : Phillips DL

Project Title:	Time-resolved resonance raman and density functional theory investigation of the intermediates and mechanism of photorelease in selected benzoin and hydroxyphenacyl esters in aqueous solutions
Investigator(s):	Phillips DL
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2002

Abstract:

The project uses time-resolved resonance Raman spectroscopy to obtain the structural information for selected benzoin and p-hydroxyphenacyl derivatives and their reaction intermediates. This research should provide valuable insight into the identity and structures of the reaction intermediates involved in the photorelease mechanisms in the important new phototrigger compounds.

Project Title:	Time-Resolved Resonance Raman and Density Functional Theory investigation of the structure, properties and chemical reactivity of selected weakly bound species containing S and/or halogen atoms
Investigator(s):	Phillips DL
Department:	Chemistry
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	09/2003

Abstract:

The proposed study will provide important characterization and insight into the structures, properties and chemical reactivity of selected radical cations, radical anions and neutral species containing weak bonds formed from a singly occupied sulfur or halogen p orbital and lone pairs of S or halogen atoms. This fundamental work will lead to an improved understanding of the likely role of these species in the biological activity of many proteins, enzymes and antibiotics as well as in protection mechanisms for biological systems attacked by ionizing radiation or other kinds of free-radical damage. The propossed work for halogen containing systems should help elucidate the likely role of these types of species in environmental and atmospheric chemistry. Comparison of the 2c-3e bonding in the radical cation and anion complexes to those of the isopolyhalomethane and halogenated solvent-halogen atom complexes that are neutral species should enable an improved understanding of how the structure, properties and chemical reactivity vary with oxidation state for these loosely bound complexes.

Project Title:	Time-Resolved Resonance Raman and Density Functional Theory investigation of the structure, properties and chemical reactivity of selected weakly bound species containing S and/or halogen atoms
Investigator(s):	Phillips DL
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2003

Abstract:

Project Title:	Photochemical and Ab initio and density functional theory studies of dehalogenation reactions in water
Investigator(s):	Phillips DL
Department:	Chemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003
Completion Date:	10/2004

Abstract:

It is important to understand the decomposition of halogenated hydrocarbons in a range of environments like the gas phase as well as in the interfacial and/or bulk regions of water and ice particles and in water solutions. To use a variety of photochemical experiments and ab initio and density functional theory studies of the dehalogenation reactions fo selected halogenated hydrocarbons in water and mixed water solvents.

Project Title:	Investigation of Water Assisted Dehalogenation Reactions of Polyhalomethanes and Other Selected Halogenated Compounds
Investigator(s):	Phillips DL
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	07/2004

Abstract:

To study: (1) observe and characterize the structure, properties and chemical reactivity of the reaction intermediates involved in the dehalogenation reactions of polyhalomethanes and other selected halogenated compounds in water solution using picosecond and nanosecond time-resolved resonance Raman spectroscopy. (2) the final products from these photochemical dehalogenation reactions will be determined using a variety of spectroscopic and analytical techniques like UV/VIS, ¹H-NMR, ¹³C-NMR, infrared absorption, pH measurements in combination with laser photochemistry experiments. (3) Ab initio chemical reaction calculations will be used to elucidate the reaction pathways and probable role of water solvent molecules in the dehalogenation reactions of polyhalomethanes and other selected halgoenated compounds to be studied and compared to the experimental results of parts 1 and 2. This will help to elucidate the reaction mechanism(s) of the dehalogenation reactions.

Project Title:	Development of novel formulations for coatings and paints employing nanotechnology
Investigator(s):	Phillips DL, Chan WK, Yuen S.W., Leung K.H.
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	10/2004

Abstract:

To collaborate with Manfield Coatings Co. Ltd., develop new coating and paint products especially those that employ nanotechnology additives that will meet the specifications of their customers who needs it for manufacturing new advanced electronic products.

Project Title:	Investigation of Water Assisted Dehalogenation Reactions of Polyhalomethanes and Other Selected Halogenated Compounds
Investigator(s):	Phillips DL
Department:	Chemistry
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

Project Title:	Time-resolved spectroscopic and density functional theory investigations of selected chemical reactions relevant to damage and repair of DNA
Investigator(s):	Phillips DL
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2005

Abstract:

refer hard copy proposal

List of Research Outputs

Chan P.Y., Ong S.Y., But Y.S. and Phillips D.L., Time-resolved resonance Raman and density functional theory investigation of the 4-biphenylnitrene dimerization reaction, Journal of Raman Spectroscopy. 2004, 35: 887-894.

Chan P.Y., Kwok W.M., Lam S.K., Chiu P. and Phillips D.L., Time-resolved resonance raman observation of the 2-fluorenylnitrenium ion reaction with guanosine to form a C8 intermediate, Journal of the American Chemical Society. 2005, 127: 8246-8247.

Chan P.Y., Zhu P. and Phillips D.L., Transient resonance raman and density functional theory study of the 7-bromo-2-fluorenylnitrenium cation, Research on Chemical Intermediates. 2005, 31(1-3): 73-84.

Chan W.S., Ma C., Kwok W.M. and Phillips D.L., Time-resolved resonance raman and density functional theory study of hydrogen-bonding effects on the triplet state of p-methoxyacetophenone, Journal of Physical Chemistry A. 2005, 109(15): 3454-3469.

Guan X., Du Y., Li Y., Kwok W.M. and Phillips D.L., Comparison of the dehalogenation of polyhalomethanes and production of strong acids in aqueous and salt (NaCI) water environments: ultraviolet photolysis of CH₂I₂, Journal of Chemical Physics. 2004, 121(17): 8399-8409.

Guan X., Lin X., Kwok W.M., Du Y., Li Y., Zhao C., Wang D. and Phillips D.L., Ultraviolet photolysis of CH₂I₂ in ,methanol: O-H insertion and HI elimination reactions to form a dimethoxymethane product, Journal of Physical Chemistry A. 2005, 109(6): 1247-1256.

Kwok W.M., Chan P.Y. and Phillips D.L., Direct observation of the 2-fluoenylnitrene and 4-methoxyphenylnitrene reactions with water using picosecond kerr-gated time-resolved resonance raman spectroscopy, Journal of Physical Chemistry B. 2004, 108: 19068-19075.

Kwok W.M., Chan P.Y. and Phillips D.L., Direct observation of the 4-Methoxyphenylnitrene intersystem crossing from S₁ to T₁ using picosecond kerr-gated time-resolved resonance raman spectroscopy, Journal of Physical Chemistry A. 2005, 109(10): 2394-2400.

Leung Y.H., Kwok W.M., Djurisic A., Phillips D.L. and Chan W.K., Time-resolved study of stimulated emission in ZnO tetrapod nanowires, Nanotechnology. Bristol, IOP Publishing Limited, 2005, 16: 579-582.

Lin X., Zhao C. and Phillips D.L., Ab initio investigation of the O-Y (Y=CH₃, H) insertion/HI elimination reactions of CH₂I-I with CH₃OH and H₂O: comparison of methanol and water catalyzed reactions, Chemical Physics Letters. 2004, 397: 488-494.

Lin X., Zhao C. and Phillips D.L., An ab inition study of the reactions of CH₂X-X (X=C1,Br, I) isopolyhalomethanes with nCH₃OH, Molecular Simulation. 2005, 31(6-7): 483-488.

Lin X., Guan X., Kwok W.M., Zhao C., Du Y., Li Y. and Phillips D.L., Water-catalyzed O-H insertion/HI elimination reactions of isodihalomethanes (CH₂X-I, where x=CI,Br, I) with water and the dehalogenation of dihalomethanes in water-solvated environments, Journal of Physical Chemistry A. 2005, 109(6): 981-998.

Ma C., Zuo P., Kwok W.M., Chan W.S., Kan T.W., Toy P.H. and Phillips D.L., Time-resolved resonance raman study of the triplet states of p-hydroxyacetophenone and the p-hydroxyphenacyl diethyl phosphate phototrigger compound, Journal of Organic Chemistry. 2004, 69(20): 6641-6657.

Ma C., Kwok W.M., Chan W.S., Zuo P., Kan T.W., Toy P.H. and Phillips D.L., Ultrafast time-resolved study of photophysical processes involved in the photodeprotection of p-Hydroxyphenacyl caged phototrigger compounds, Journal of the American Chemical Society. 2005, 127(5): 1463-1472.

Phillips D.L., A resonance raman study on metal-metal interactions in binuclear two- and three- coordinated metal complexes, Abstract of 15^th International Symposium on Photophysics and Photochemistry of Coordination Compounds, Hong Kong, P.R. CHINA, July 6-11,2004.

Phillips D.L., Time-resolved spectroscopic investigation of p-Hydroxyphenacyl caged phototrigger compunds, Abstract of 12^th International Conference on Time-Resolved Vibrational Spectroscopy (TRVSXII), national Institute of Standards and Technology (NIST), Gaithersburg, MD, U.S.A., May 23-27, 2005 (Invited Talk and abstract). 2005.

Phillips D.L., Kwok W.M., Zhao C., Guan X., Du Y., Li Y. and Wang D., Water assisted dehalogenation reactions of selected isopolyhalomethanes, halomethanols and haloformaldehydes, Abstract of 229^th ACS National Meeting, San Diego, California, U.S.A., March 13 - March 17, 2005. Phys. 2005.

Phillips D.L., Water catalyzed dehalogenation reactions of isobromoform and its reaction products with water, Abstract of XIX^th International Conference on Raman Spectroscopy (ICORS 2004), Brisbane, Australia, August 8-13,2004.

Phillips D.L., Water catalyzed dehalogenation reactions: Buliding a nanoscale water solvated reaction system one molecule at a time, Abstract of Pacific Rim conference in Nano Science, Broome, Western Australia, September 7-11,2004 (Invited Talk and Abstract). 2004.

Phillips D.L., Water catalyzed edhalogenation reactions: building a nanoscale chemical reaction system one water molecule at a time , Abstract of International Conference on Optoelectronics and Spectroscopy of Naon-Structured Thin Films and Materials (ICOSFM'2004), Beijing, P.R. CHINA, August 2-5,2004.

Wang D., Zhao C. and Phillips D.L., Samarium(III) carbenoid as a competing reactive species in samarium-promoted cyclopropanation reactions, Journal of Organic Chemistry. 2004, 69: 5512-5515.

Wong K.L., Kwok W.M., Wong W.T., Phillips D.L. and Cheah K.W., Green and red three-photon upconversion from polymeric lanthanide(III) complexes, Angewandte Chemie International Edition. 2004, 43(35): 4659-4662.

Wong K.L., Law G.L., Kwok W.M., Wong W.T. and Phillips D.L., Simultaneous observation of green multiphoton upconversion and red and blue NLO processes from polymeric terbium(III) complexes, Angewandte Chemie International Edition. 2005, 44: 3436-3439.

Zhao C., Lin X., Kwok W.M., Guan X., Du Y., Wang D., Hung K.F. and Phillips D.L., Water-catalyzed dehalogenation reactions of the isomer of CBr₄ and its reaction products and a comparison to analogous reactions of the isomers of d- and trihalomethanes, Chemistry - A European Journal. 2005, 11(4): 1093-1108.

Zhao Y., Ma C.Y., Yuen S.N. and Phillips D.L., Raman spectroscopic determination of extent of O-esterification in acetylated soy protein isolates, Food Chemistry. 2004, 87: 477-481.

Zheng X.M., Li Y. and Phillips D.L., Resonance raman study of the short-time photodissociation dynamics of the A-band absorption of cycloproplyI iodide in cyclohexane solution, Journal of Physical Chemistry A. 2004, 108: 8032-8039.

Zhu X.M., Zhang S.Q., Zheng X.M. and Phillips D.L., Resonance raman study of short-time photodissociation dynamics of the charge-transfer band absorption of nitrobenzene in cyclohexane solution, Journal of Physical Chemistry A. 2005, 109(13): 3086-3093.

Researcher : Pui YL

List of Research Outputs

Tam K.H., Pui Y.L., Zhu N., Chiu P. and Chan M.C.W., Studies of zirconium(IV) polyolefin catalysts bearing tridentate pyridine-2,6-bis(phenolate) auxiliaries with different donor groups, The 229^th National Meeting of the American Chemical Society, San Diego, USA, March 13-17, 2005.

Researcher : Ren J

List of Research Outputs

Ding J., Chan G.K.Y., Ren J. and Xiao F.S., Platinum and platinum-ruthenium nanoparticles supported on ordered mesoporous carbon and their electrocatalytic performance for fuel cell reactions, Electrochimica Acta. 2005, 50: 3131-3141.

Researcher : Sham IHT

Project Title:	Magnitized dendrimers and hyperbranched polymers for controlled delivery of targeted drugs
Investigator(s):	Sham IHT, Che CM, Kung H
Department:	Chemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To achieve controlled delivery of drugs to target sites using magnetized dendrimers and hyperbranched polymers as vehicles.

List of Research Outputs

Bernhardt E., Bach C., Bley B., Wartchow R., Wesphal U., Sham I.H.T., Von Ahsen B., Wang C., Willner H., Thompson R.C. and Aubke F., Homoleptic, s-bonded octahedral [M(CO)₆]²⁺ cations of iron(II), ruthenium(II), and osmium(II): Part 1:Syntheses, thermochemical and vibrational characterizations, and molecular structures as [Sb₂F₁₁]^- and [SbF₆]^- salts. A comprehensive, comparative studys, Inorganic Chemistry. 2005, 44: 4189-4205.

Kwok C.C., Yu S.C., Sham I.H.T. and Che C.M., Self-aggregated phosphorescent platinum(II) polymeric material from modified poly(4-vinylpyridine), Chemical Communications. 2004, 2512-2513.

Kwok C.C., Yu S.C., Sham I.H.T. and Che C.M., Self-assembled zinc(II) Schiff base polymers for applications in polymer light-emitting devices, Chemical Communications. 2004, 2758-2759.

Kwok C.C., Ngai H.M.Y., Chan J.S.C., Sham I.H.T., Che C.M. and Zhu N., [(O^N^N)PtX] Complexes as a new class of light-emitting materials for electrophosphorescent devices, Inorganic Chemistry. 2005, 44: 4442-4444.

Researcher : Shum YT

List of Research Outputs

Yang Z., Wong L.M.E., Shum Y.T., Che C.M. and Hui Y., Fluorophore-appended steroidal saponin (Dioscin and Polyphyllin D) derivatives, Organic Letters. 2005, 7: 669-672.

Researcher : Si S

List of Research Outputs

Fung Y.S., Si S., Zhu D. and Sun H., Nanoporous TiO₂ film as coating for piezoelectric crystal sensor in the detection of organic vapours in air , Abstract of the 10^th International Meeting on Chemical Sensors (IMCS-10), Tsukuba, Japan, July 11-14, 2004, 3P029. 2004.

Fung Y.S., Si S., Zhu D. and Sun H., Nanoporous TiO₂ film as coating for piezoelectric crystal sensor in the detection of organic vapours in air , Chemical Sensors. 2004, 20: 698-699.

Si S., Fung Y.S. and Hu H., Photoelectrochemical biosensor based on formaldehyde dehydrogenase/CdTe Nanoparticles, Abstract of 7^th Asian conf. on Anal. Sci., Hong Kong, July 28-31, 2004, F054-P, p352. 2004, p352.

Sun H., Si S., Zhang Y., Zhu D. and Fung Y.S., Piezoelectric quartz crystal (PQC) with photochemically deposited nano-sized Ag particles for determinig cyanide at trace levels in water, Chemical Sensors. 2004, 20: 500-502.

Sun H., Si S., Zhang Y., Zhu D. and Fung Y.S., Piezoelectric quartz crystal (PQC) with photochemically deposited nano-sized Ag particles for determining cyanide at trace levels in water, Abstract of the 10^th International Meeting on Chemical Sensors (IMCS-10), Tsukuba, Japan, July 11-14, 2004, 2P061. 2004.

Researcher : Siu AFM

Project Title:	Characterisation of neurotransmitters
Investigator(s):	Siu AFM, Che CM
Department:	Chemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To study neurotransmitter on the following two aspects: (1) characterisation of the molecular interactions between neurotransmitters (dopamine, norepinephrine, epinephrine etc) and ions (Na⁺, etc); (2) characterisation of the conformational change of neurotransmitters at the model protein receptor binding sites.

Researcher : Siu KMP

List of Research Outputs

Siu K.M.P., Ma D.L. and Che C.M., Luminescent cyclometalated platinum(II) complexes with amino acid ligands for protein binding, Chemical Communications. 2005, 1025-1027.

Siu K.M.P., Luminescent cyclometalated platinum(II) complexes: protein binding studies and biological applications(PhD). 2005.

Researcher : Siu SO

List of Research Outputs

Chu I.K., Lam N.W. and Siu S.O., Facile generation of tripeptide radical cations in Vacuo via intramolecular electron transfer in cu II tripeptide complexes containing sterically encumbered terpyridine ligands, Journal of the American Society for Mass Spectrometry. 2005, 16: 763-771.

Lam N.W., Siu S.O. and Chu I.K., Efficient formation of peptide radical cations in vacuo by electron transfer of Cu^II(Amine)peptide complexes, Poster Presentation in 12th Symposium on Chemistry Postgraduate Research in Hong Kong, City University of Hong Kong, April 23, 2005. Hong Kong, Poster No: AE-22.

Lam N.W., Siu S.O. and Chu I.K., Efficient formation of peptide radical cations in vacuo by electron transfer of Cu^II(Amine)peptide complexes, Poster Presentation in Proceedings of the 53rd ASMS Conference on Mass Spectrometry and Allied Topics, San Antonio, Texas, U.S.A., June 5-9, 2005.

Researcher : Song K

List of Research Outputs

Chen F., Song K. and Yang D., g⁴-Aminoxy peptides as new peptidomimetic foldamers, The 12^th Symposium on Chemistry Postgraduate Research in Hong Kong,The City University of Hong Kong, April 23,2005.

Researcher : Su Z

List of Research Outputs

Wang X., Wong L.H., Hu L., Chan C.Y., Su Z. and Chen G., Improving the accuracy of density-functional theory calculation: the statistical correction approach, Journal of Physical Chemistry A. 2004, 108(40): 8514-8525.

Researcher : Sun D

List of Research Outputs

Fung Y.S., Sun D. and Yeung C.Y., Separation, quantitation and binding study of serum proteins with bilirubin by capillary electrophoresis under physiological conditions, Abstract of 5^th Asia-Pacific International Symposium on Microscale Separation and Analysis (APCE2004), Seoul, South Korea, Dec 5-8, 2004, P10. 2004, p76.

Researcher : Sun H

Project Title:	Recognition of antimonials by lactoferrin and trypanothione: implications for uptake, activation and targeting
Investigator(s):	Sun H, Chow L.M.C.
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	08/2002

Abstract:

The project focuses on the interaction between antimony antileishmanial agents and peptides and proteins. The project aims at understanding the recognition of antimonial drugs and related compounds by lactoferrin (and transferrin) and investigating the possible reduction of two oxidation states (Sbv to SbIII) and further complexation of SbIII with trypanothione.

Project Title:	The molecular basis of biological functions of the neuronal growth inhibitory factor (metallothionein-3)
Investigator(s):	Sun H, Huang Z.X.
Department:	Chemistry
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2003

Abstract:

To provide a clear and precise picture of the structure of MT-3 and its relation to the biological functions, and moreover, to establish a state-of-the-art center for the study of metalloproteins.

Project Title:	Structure-function study of a putatively functional domain of divalent metal transporter DMT1
Investigator(s):	Sun H
Department:	Chemistry
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2003

Abstract:

To address whether the secondary structure of TM4 changes after mutation (G185R), the structural changes of these membrane peptides at different pH values and possible aggregation of the peptide after mutation; to address how the three-dimensional structural of TM4 affects the function of the protein; to approach the position and orientations of TM4 and its mutant G185R with respect to detergent micelles and phospholipid bilayers; to investigate the metal transport properties of TM4 in model phospholipid vesicular systems, which was widely used for studying the transport mechanism.

Project Title:	Overexpression and characterization of a histidine-rich protein: implication for metal storage and detoxification
Investigator(s):	Sun H, Huang J
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004

Abstract:

To investigate nickel uptake and release properties and the effects of nickel on hpn seondary structure; to provide the structure-function of the protein; to offer a basis for an external grant application.

Project Title:	Characterization of a nickel-storage protein Hpn: its relation with bismuth antiulcer drugs
Investigator(s):	Sun H, Huang J
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2004

Abstract:

To evaluate the nickel binding properties of the protein. Hpn will be overexpressed in E. coli using recombinant DNA technology; to evaluate the effects that nickel (and zinc) have upon Hpn secondary structure and stability; to get preliminary data on the three-dimensional structure of the protein. The protein structure will be investigated by NMR spectroscopy and other spectroscopic techniques.; to investigate the competitive binding of bismuth and Ni² to Hpn and the structural differences between the Ni²⁺ and Bi³⁺ loaded forms.

Project Title:	Characterization of a nickel-storage protein Hpn: its relation with bismuth antiulcer drugs
Investigator(s):	Sun H
Department:	Chemistry
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

Project Title:	Bismuth and Zinc Complexes as Antiviral and Anticancer Agents
Investigator(s):	Sun H, Zheng B
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2005

Abstract:

Both bismuth (Bi) and zinc (Zn) compounds have long been associated with medicine, and particularly used as antimicrobial agents in clinical [1,2]. For example, colloidal bismuth subcitrate (De-Nel®) and rantidine bismuth citrate (Pylorid®) have been recommended as a standard treatment for Helicobacter pylori infection and peptic ulcer together with antibiotics [3]. Zinc compounds (e.g., Zenullose) were also showed effective for the treatment of the common cold, a disease caused by rhinoviruses although the mechanism of action remains unclear. Since zinc is an essential element and bismuth is nearly non-toxic, in contrast to other heavy metals, it would be very important and interesting to develop bismuth- and zinc-containing compounds as potential either antiviral or anticancer agents. Our preliminary work has showed that the clinically used bismuth compound (Pylorid®) can effectively inhibit the production of SARS-CoV in vitro (FRhk-4 cells) with extremely high selectivity (EC50: CC50= 5.9 µM: 5 mM). Zinc compound was recently found to be active against 3C-like proteinase (3CL), an essential protein fore the life cycle of SARS-CoV [4]. Promising anticancer activities of bismuth and zinc complexes were also demonstrated [5]. Using our initial work as a foundation, we will combine the expertise of PI and Co-I to design and synthesize bismuth- and zinc-containing complexes as antiviral and anticancer agents and explore the structure-and-activity relationship. This study will not only improve our knowledge of the medicinal chemistry of bismuth and zinc (as novel antiviral and anticancer agents), but also offer a basis to attract an external funding. We intend to achieve three separate but closely related objectives:(A) To design and synthesize Bi- and Zn-containing complexes for biological tests;(B) To study biocoordination chemistry of these complexes under biologically relevant conditions;(C) To screen antiviral and anticancer activities in different systems.

List of Research Outputs

Fung Y.S., Si S., Zhu D. and Sun H., Nanoporous TiO₂ film as coating for piezoelectric crystal sensor in the detection of organic vapours in air , Abstract of the 10^th International Meeting on Chemical Sensors (IMCS-10), Tsukuba, Japan, July 11-14, 2004, 3P029. 2004.

Fung Y.S., Si S., Zhu D. and Sun H., Nanoporous TiO₂ film as coating for piezoelectric crystal sensor in the detection of organic vapours in air , Chemical Sensors. 2004, 20: 698-699.

Fung Y.S., Sun H., Zhang Y., Yao S. and Yam W.C., PCR/DNA piezoelectric quartz crystal biosensor for bacteria sensing, Abstract of 2^nd France China Workshop on Surface Molecules of Biological Interest: Biosensor Applications, October 13-16, 2004, Céret, France, p 36. 2004, 36.

Fung Y.S., Sun H., Zhang Y., Yao S.Z. and Yam W.C., PCR/DNA piezoelectric quartz crystal biosensor for bacteria sensing, Invited lecture at Plenary Session of 2^nd France China Workshop on Surface Molecules of Biological Interest: Biosensor Application, Céret, France, October 13-16. 2004.

Fung Y.S., Yam W.C., Zhang Y. and Sun H., PCR/DNA quartz crystal microbalance biosensor for detecting bacteria in environmental water samples, Abstract of The 56^th Annual Pittsburgh Conference and Exposition on Analytical Chemistry and Applied Spectroscopy (PITTCONF 2005), Orlando, Florida, USA, February 27-March 4,2005, 2250-5. 2005, 2250-2255.

Jin L., Szeto K.Y., Zhang L., Du W. and Sun H., Inactivation of alcohol dehydrogenase by bismuth complex, Journal of Inorganic Biochemistry. 2004, 98: 1331-1337.

Li F., Li H., Hu L., Kwan M.F., Chen G., He Q. and Sun H., Structure, assembly, and topology of the G185R mutant of the fourth transmembrane domain of divalent metal transporter, Journal of the American Chemical Society. 2005, 127(5): 1414-1423.

Li H., Li F., Kwan M.F., He Q. and Sun H., NMR structres and orientation of the fourth transmembrane domain of the rat divalent metal transporter (DMT1) with G185D mutation in SDS micelles, Biopolymers. 2005, 77: 173-183.

Li H.Y., Fung K.L., Ching Y.P., Ng I.O.L., Chung S.S.M., Sze K.H., Ko B.C.B. and Sun H., Structural study of the SAM domain of the deleted in liver cancer 2 (DLC2), Chemistry Symposium of Hong Kong, March 2005.

Sun H. and Yang N., Bismuth complex as an enzyme inhibiotr: From antibacterium to antivirus, Abstract of the Second Asian Biological Inorganic Chemistry Conference (AsBIC-II), Goa, Indai, Dec 5-10, 2004.

Sun H. and Fung Y.S., Determination of atmospheric carbonyl compounds by MIP-SPE coupled MEKC method, Abstract of 7^th Asian Conf. on Anal. Sci., Hong Kong, July 28-31, 2004, H074-P. 2004, p486.

Sun H., Chan K.Y. and Fung Y.S., Integrating MEKC with sampling and pre-treatment for gaseous and particulate carbonyl determination, Abstract of 5^th Asia-Pacific International Symposium on Microscale Separation and Analysis (APCE2004), Dec 5-8, 2004, Seoul, South Korea. 2004, 024: 44.

Sun H., Chan K.Y. and Fung Y.S., Integrating MEKC with sampling and pre-treatment for gaseous and particulate carbonyl determination, Invited lecture at Plenary Session of the 5th Asia-Pacific International Symposium on Microscale Separation and Analysis (APCE2004), Seoul, South Korea, Dec 5-8 . 2004.

Sun H., Si S., Zhang Y., Zhu D. and Fung Y.S., Piezoelectric quartz crystal (PQC) with photochemically deposited nano-sized Ag particles for determinig cyanide at trace levels in water, Chemical Sensors. 2004, 20: 500-502.

Sun H., Si S., Zhang Y., Zhu D. and Fung Y.S., Piezoelectric quartz crystal (PQC) with photochemically deposited nano-sized Ag particles for determining cyanide at trace levels in water, Abstract of the 10^th International Meeting on Chemical Sensors (IMCS-10), Tsukuba, Japan, July 11-14, 2004, 2P061. 2004.

Sun H., Ge R., Watt R.M., He Q. and Huang J., Towards the understanding of nickel trafficking in helicobacter pylori: Expression and characterization of a his-rich protein, HPN, 10th SCBA International Symposium, Beijing, China, 18-23 July 2004.

Sun R.W.Y., Yu W.Y., Sun H. and Che C.M., In vitro inhibition of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase by gold(III) porphyrins, ChemBioChem. 2004, 5(9): 1293-1298.

Sun X., Sun H., Ge R., Richter M., Woodworth R.C., Mason A.B. and He Q., The low pK_a value of iron-binding ligand tyr188 and its implication in iron release and anion binding of human transferrin, FEBS Letters. 2004, 573(1-3): 181-185.

Yan S.C., Jin L. and Sun H., ⁵¹ Sb-antimony in medicine, Metallotherapeutic Drugs and Metal-Based Diagnostic Agents: The Use of Metals in Medicine. John Wiley & Sons, Ltd, 2005, 441-461.

Yang P., Sun X., Chiu J., Sun H. and He Q., Transferrin-mediated gold nanoparticle cellular uptake, Bioconjugate Chemistry. 2005, 16: 494-496.

You T., Sun H. and Fung Y.S., Electrochemical detector for indirect detection of amino acids after CE separation, Abstract 7^th Asian Conf. on Anal. Sci., Hong Kong SAR, China, July 28-31, 2004, F079-P. 2004, p491.

Zhang Y., Sun H., Fung Y.S. and Yao S., Quantitative determination of bacteria by DNA piezoelectric biosensor, Abstract of 7^th Asian conf. on anal. Sci., Hong Kong SAR, China, July 28-31, 2004, E063-P. 2004, p296.

Zheng B., Guan Y., He M.L., Sun H., Du L., Zheng Y., Wong K.L., Chen H., Chen Y., Lu L., Tanner J.A., Watt R.M., Niccolai N., Bernini A., Spiga O., Woo P.C.Y., Kung H.F., Yuen K.Y. and Huang J., Synthetic peptides outside the spike protein heptad repeat regions as potent inhibitors of SARS-associated coronavirus, Antiviral Therapy. 2005, 10: 393-403.

Zhu D., Sun H. and Fung Y.S., Electrochemical performance of nano-TiO2 modified LiCoO2 cathode material in room temperature molten salts for lithium battery application, Invited lecture at Electrodeposition Session of 1^st Asian and 9^th China-Japan Bilateral Conference on Molten Salt Chemistry and Technology, Wuhu, China, May 23-27. 2005.

Zhu D., Sun H. and Fung Y.S., Electrochemical performance of nano-TiO2 modified LiCoO2 cathode material in room temperature molten salts for lithium battery application, Proceedings 1^st Asian and 9^th China-Japan Bilateral Conference on Molten Salt Chemistry and Technology, Wuhu, China, May 23-27, 2005, 54-57. 2005, 54-57.

Researcher : Sun H

List of Research Outputs

Fung Y.S., Si S., Zhu D. and Sun H., Nanoporous TiO₂ film as coating for piezoelectric crystal sensor in the detection of organic vapours in air , Chemical Sensors. 2004, 20: 698-699.

Jin L., Szeto K.Y., Zhang L., Du W. and Sun H., Inactivation of alcohol dehydrogenase by bismuth complex, Journal of Inorganic Biochemistry. 2004, 98: 1331-1337.

Sun R.W.Y., Yu W.Y., Sun H. and Che C.M., In vitro inhibition of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase by gold(III) porphyrins, ChemBioChem. 2004, 5(9): 1293-1298.

Yan S.C., Jin L. and Sun H., ⁵¹ Sb-antimony in medicine, Metallotherapeutic Drugs and Metal-Based Diagnostic Agents: The Use of Metals in Medicine. John Wiley & Sons, Ltd, 2005, 441-461.

Yang P., Sun X., Chiu J., Sun H. and He Q., Transferrin-mediated gold nanoparticle cellular uptake, Bioconjugate Chemistry. 2005, 16: 494-496.

Zhu D., Sun H. and Fung Y.S., Electrochemical performance of nano-TiO2 modified LiCoO2 cathode material in room temperature molten salts for lithium battery application, Proceedings 1^st Asian and 9^th China-Japan Bilateral Conference on Molten Salt Chemistry and Technology, Wuhu, China, May 23-27, 2005, 54-57. 2005, 54-57.

Researcher : Sun RWY

List of Research Outputs

Ren Y., Li W., Liu Q., Yu W.Y., Sun R.W.Y., Che C.M. and Tam P.K.H., Gold (III) porphyrines: a novel chemotherapeutic agent for human neuroblastoma, 51st Annual International Congress of British Association of Paediatric Surgeons, Oxford, U.K. 27-30 July. 2004.

Sun R.W.Y., Yu W.Y., Sun H. and Che C.M., In vitro inhibition of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase by gold(III) porphyrins, ChemBioChem. 2004, 5(9): 1293-1298.

Researcher : Sun X

List of Research Outputs

Sun X., Sun H., Ge R., Richter M., Woodworth R.C., Mason A.B. and He Q., The low pK_a value of iron-binding ligand tyr188 and its implication in iron release and anion binding of human transferrin, FEBS Letters. 2004, 573(1-3): 181-185.

Yang P., Sun X., Chiu J., Sun H. and He Q., Transferrin-mediated gold nanoparticle cellular uptake, Bioconjugate Chemistry. 2005, 16: 494-496.

Zhang J., Liang J., Sun X., Zhou H., Zhu N., Zhou Z.Y., Chan P.W.H. and Che C.M., Chiral osmium complexes with sterically bulky schiff-base lignads. Crystal structures of Os(IV) derivatives and the reactivity and catalytic cyclopropanation of alkenes with EDA, Inorganic Chemistry. 2005, 44: 3942-3954.

Researcher : Sun X

List of Research Outputs

Yang P., Sun X., Chiu J., Sun H. and He Q., Transferrin-mediated gold nanoparticle cellular uptake, Bioconjugate Chemistry. 2005, 16: 494-496.

Researcher : Sy LK

Project Title:	Structural elucidation and biological study of polysaccharides isolated from traditional Chinese medicines
Investigator(s):	Sy LK, Che CM, Man RYK
Department:	Pharmacology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To study the sequence, branching and conformational structures of the polysaccharides isolated from Traditional Chinese Medicines.

Researcher : Sze KH

Project Title:	Automated resonance assignment and high-throughput structure determination of proteins by NMR
Investigator(s):	Sze KH
Department:	Chemistry
Source(s) of Funding:	Seed Funding for New Staff
Start Date:	03/2004

Abstract:

To develop efficient and effective NMR experimental and computational methods for automated assignment of NMR resonances; to develop experimental and computational methods for high throughput determination of protein structures.

Project Title:	Development and application of NMR methods based on solvent exposed amides (SEA) experiments for proteins
Investigator(s):	Sze KH, Zhu G.
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	11/2004

Abstract:

To resolve overlapping resonances in the NMR spectra of proteins; to map the protein-protein, protein-nucleic acid or protein-ligand interaction sites; to study unfolding/folding pathway of proteins.

Project Title:	Development and application of NMR methods based on solvent exposed amides (SEA) experiments for proteins
Investigator(s):	Sze KH
Department:	Chemistry
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

Project Title:	Structure and Function Studies of Human Telomerase Reverse Transcriptase C-Terminal Polypeptide (hTERTC27) - Structure determination of hTERTC27 by NMR spectroscopy
Investigator(s):	Sze KH, Lin MC
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2005

Abstract:

The human telomerase reverse transcriptase (hTERT) is the catalytic subunit of telomerase holoenzyme as well as the rate-limiting component of the telomerase enzyme complex. By reverse transcribing the telomerase RNA component (hTR) to the telomeric DNA sequence, hTERT synthesizes and elongates the terminal telomeric DNA, thereby counteracting the cellular senescent program orchestrated by telomere shortening. Thus, hTERT activation is essential for cell immortalization, malignant transformation (Meyerson et al 1997; Sonoda et al 2001), and cancer cell survival (Hahn et al 1999; Zhang et al 1999)The hTERT is a 127-kDa protein with 1132 amino acid residues (Meyerson et al 1997), containing a hTR specific binding domain at its N-terminus (Beattie et al 2000; Lai et a; 2001) and a RT-domain at the central region (Meyerson et al 1997; Friedman et al. 1999). Both of these functional domains are required for the reverse transcriptase activity. hTERT also needs to be translocalized to the nucleus and targeted to the telomere ends to be functional. Nuclear translocation has been shown to be regulated by the interactions between the hTERT C terminus and the protein 14-3-3 (Seimiya et al., 2000). However, the mechanism for the telomere end targeting of hTERT is not understood..We have constructed a polypeptide containing the C terminal 27 kDa hTERT (hTERTC27). We recently showed that hTERTC27 is capable of nuclear translocation and telomere-end targeting. Ectopic overexpression of this polypeptide in hTERT positive HeLa cells specifically causes telomere dysfunction and rapid chromosome end-fusion, resulting in cell apoptosis and senescence (Huang et al 2002). The phenotype is similar to that of the dominant negative mutant of the telomere-binding protein TRF2 (DN-TRF2). DN-TRF2 interferes with the binding of TRF2 to telomere and rapidly induces telomere dysfunction and cell growth inhibition without affecting the telomerase enzyme activity (Steensel et al 1998). Therefore, hTERTC27 may act by disrupting the normal function of the hTERT C-terminus, which may include binding to various components at the telomere end and maintaining the telomere structure.The objective of the proposed works is to understand the structure-function of hTERT C-terminus by determination of the three-dimensional structure of hTERTC27 using NMR spectroscopy. Our proposed works will address the following questions:(1) What is the structure of hTERTC27? (2) How does the structure of hTERTC27 related to the function of hTERT? We aim at identifying the functional motifs, elucidating the molecular targets and mechanisms for hTERTC27 induced telomere dysfunction.

List of Research Outputs

Chiu K.H., Liu F.Y., Hu Y.C., Sze K.H., Lyu P.C. and Chou S.H., Letter to the editor: NMR structure notoe - Solution structure of a bacterial BolA-like protein XC975 from a plant pathogen Xanthomonas campestris pv. campestris, Journal of Biomolecular NMR . 2005, 31(2): 167-172.

Guan X., Tse M.K., Yang Y., Sze K.H., Cheung K.K. and Wong K.B., Structure and dynamics of a thermophilic acylphosphatase from Pyrococcus horikoshii by NMR spectroscopy - structural basis of thermostability and enzymatic activities, Twelfth Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong, The City University of Hong Kong, 23 Apr. 2005. 43.

Li H.Y., Fung K.L., Ching Y.P., Ng I.O.L., Chung S.S.M., Sze K.H., Ko B.C.B. and Sun H., Structural study of the SAM domain of the deleted in liver cancer 2 (DLC2), Chemistry Symposium of Hong Kong, March 2005.

Sze K.H., Automated determination of protein NMR resonance assignments and structure, Invited Speaker at Institute of Biochemistry, Stuctural Proteomics Center, national Chung-Hsing University, Taiwan, 3 Aug, 2004.

Sze K.H., Yang Y., Guan X., Tse M.K. and Barsukov I., Combined computational and experimental developments for automated determination of protein structures by NMR, XXI International Conference on Magnetic Resonance in Biologicall Systems, Hyderabad, India, 16-21 Jan, 2005. 94.

Sze K.H., Lin D., Liu X., Yang Y., Guan X. and Zhu G., Mapping protein-protein interactions by solvent exposed amides experiment, XXI International Conference on Magnetic Resonance in Biologicall Systems, Hyderabad, India, 16-21 Jan, 2005. 95.

Sze K.H., Yang Y., Guan X., Tse M.K., Cheung K.K. and Wong K.B., Structure and dynamics of a thermophilic acylphosphatase from Pyrococcus horikoshii by NMR spectroscopy - structural basis of thermostability and enzymatic activities, XXI International Conference on Magnetic Resonance in Biologicall Systems, Hyderabad, India, 16-21 Jan, 2005. 155.

Tse M.K., Sze K.H., Lin D., Liu X. and Zhu G., Water accessibility perturbation: A novel protein-protein interaction mapping method by solvent exposed amides NMR experiment, The 12^th Symposium on Chemistry Postgraduate Research in Hong Kong, The City University of Hong Kong, Hong Kong, Apr 23,2005. 44.

Yang Y., Guan X., Tse M.K., Sze K.H. and Haynes R.K., Eluciation of solution conformations of loloatins by NMR spectroscopy, The 12^th Symposium on Chemistry Postgraduate Research in Hong Kong, The City University of Hong Kong, Hong Kong, Apr 23,2005. 45.

Researcher : Sze-To L

List of Research Outputs

Shek I.P.Y., Yeung W.F., Lau T.C., Zhang J., Gao S., Sze-To L. and Wong W.T., Ni^IIRu^II and Cu^IIRu^II coordination polymers constructed from [Ru(CN)₆]^4-, European Journal of Inorganic Chemistry. 2005, 364-370.

Yang Y., Sze-To L., Ouyang G.F., Huang Z.Q., Wong W.T. and Ng S.W., m₂Diiodotetrakis(2-hydroxymethyl-1-methyl-1-imidazole-N³)dicadmium(II) bis[triiodo(2-hydroxymethyl-1-methyl-1-imidazole-N³)cadmate(II)] dihydrate, Applied Organometallic Chemistry. 2005, 19: 352-353.

Researcher : Szeto KY

List of Research Outputs

Jin L., Szeto K.Y., Zhang L., Du W. and Sun H., Inactivation of alcohol dehydrogenase by bismuth complex, Journal of Inorganic Biochemistry. 2004, 98: 1331-1337.

Researcher : Tam KH

List of Research Outputs

Tam K.H., Pui Y.L., Zhu N., Chiu P. and Chan M.C.W., Studies of zirconium(IV) polyolefin catalysts bearing tridentate pyridine-2,6-bis(phenolate) auxiliaries with different donor groups, The 229^th National Meeting of the American Chemical Society, San Diego, USA, March 13-17, 2005.

Researcher : Tam WS

List of Research Outputs

Tam W.S., Ye J. and Cheung A.S.C., Near-infrared laser spectroscopy of NiI, Journal of Chemical Physics. 2004, 121(19): 9430-9435.

Researcher : Tang HS

List of Research Outputs

Lu X., Tang H.S., Ko C.C., Wong K.Y., Zhu N. and Yam V.W.W., Anion-assisted trans-cis isomerization of palladium(II) phosphine complexes containing acetanilide functionalities through hydrogen bonding interactions, Chemical Communications. 2005, 1572-1574.

Tang H.S., Lu X., Ko C.C., Wong J.K.Y. and Yam V.W.W., First Observation of Ion-Induced Trans-Cis Isomerization of Palladium(II) Phosphine Complex Containing Various Receptor Sites, The XX IUPAC Symposium on Photochemistry, Granada, Spain (Poster presented by Miss Hau-San Tang). 2004.

Tang H.S., Lu X., Ko C.C. and Yam V.W.W., Synthesis, luminescence and ion-induced trans-cis isomerization of palladium(II) phosphine complexes containing various receptor sites, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Miss Hau San Tang). 2004, P-56.

Researcher : Tang WS

List of Research Outputs

Tang W.S., Wong M.C., Lu X., Zhu N. and Yam V.W.W., Functionalized Platinum(II) Alkynyl Complexes as Colorimetric and Luminescence pH Sensors, The XX IUPAC Symposium on Photochemistry, Granada, Spain (Poster presented by Miss Wing-Suen Tang). 2004.

Tang W.S., Wong M.C., Lu X., Zhu N. and Yam V.W.W., Functionalized platinum(II) alkynyl complexes as colorimetric and luminescence _pH and ion sensors, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Miss Wing Suen Tang). 2004, P-57.

Wong M.C., Tang W.S., Lu X., Zhu N. and Yam V.W.W., Functionalized platinum(II) terpyridyl alkynyl complexes as colorimetric and luminescence pH sensors, Inorganic Chemistry. 2005, 44(5): 1492-1498.

Wong M.C., Tang W.S., Chu B.W.K., Zhu N. and Yam V.W.W., Synthesis, photophysical properties, and biomolecular labeling studies of luminescent platinum(II)-terpyridyl alkynyl complexes, Organometallics. 2004, 23(14): 3459-3465.

Researcher : Tang WS

List of Research Outputs

Researcher : Tang YW

List of Research Outputs

Tang Y.W., Chan G.K.Y. and Szalai I., Sturctural and transport properties of an SPC/E electrolyte in a nanopore, Journal of Physical Chemistry B. 2004, 108: 18204-18213.

Researcher : Tao CH

List of Research Outputs

Tao C.H., Zhu N. and Yam V.W.W., Room-temperature phosphorescence and energy transfer in luminescent multinuclear platinum(II) complexes of branched alkynyls, Chemistry - A European Journal. 2005, 11: 1647-1657.

Tao C.H., Synthesis and luminescence studies of branched carbon-rich platinum(II) and palladium(II) alkynyl complexes - versatile building blocks for multinuclear(PhD). 2004.

Tao C.H., Wong M.C., Zhu N. and Yam V.W.W., Synthesis, structural characterisation and electrochemical studies of luminescent carbazole-containing platinum(II) and palladium(II) alkynyl complexes, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Mr. Chi Hang Tao). 2004, P-59.

Researcher : Tao CH

List of Research Outputs

Tao C.H., Synthesis and luminescence studies of branched carbon-rich platinum(II) and palladium(II) alkynyl complexes - versatile building blocks for multinuclear(PhD). 2004.

Researcher : Tong HY

List of Research Outputs

Li Z., Liao C., Ko C.B., Shan S., Tong H.Y., Yin Z., Pan D., Wong K.W., Shi L., Ning Z.Q., Hu W., Zhou J., Chung S.S.M. and Lu X.P., Design, synthesis, and evaluation of a new class of noncyclic 1,3-dicarbonyl compounds as PPARa selective activators, Bioorganic & Medicinal Chemistry Letters . 2004, 14: 3507-3511.

Researcher : Tong SM

Project Title:	High-valent iron porphyrins
Investigator(s):	Tong SM, Che CM
Department:	Chemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To investigate if dioxoiron (VI) porphyrin complex participates in the biological cycles of oxygen activation.

Researcher : Toy PH

Project Title:	The development of polymer-based strategies for organic synthesis
Investigator(s):	Toy PH
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	12/2002

Abstract:

The project attempts to examine new polymers with improved performance and identify their properties that are responsible. Both the chemical structure and physical morphology of the polymers will be optimized. The study also develops new applications for polymer-assisted organic synthesis that combine the use of both insoluble and soluble polymers as carriers for reagents and compounds.

Project Title:	The development of tetrahydrofuran based polymers for polymer assisted organic synthesis
Investigator(s):	Toy PH
Department:	Chemistry
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	09/2003

Abstract:

To synthesize and characterize novel cross-linked tetrahydrofuran based polymers using cationic, anionic and ring-opening metathesis polymerization strategies; to assess the utility of the new polymers in both solid-phase and solution-phase organic synthesis in order to study the optimum polymer structure and morphology in such applications.

Project Title:	The development of tetrahydrofuran based polymers for polymer assisted organic synthesis
Investigator(s):	Toy PH
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2003

Abstract:

Project Title:	Solvent effects in samarium mediated cyclopropanation reactions
Investigator(s):	Toy PH
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2004
Completion Date:	02/2005

Abstract:

To investigate one of the most fundamental aspects of the chemistry of these metals and therefore be complimentary to other research that is ongoing at HKU since understanding how solvents affect the reactivity of such metals should greatly increase their utility.

Project Title:	Polymer Supported Convergent Combinatorial Parallel Synthesis
Investigator(s):	Toy PH
Department:	Chemistry
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2004

Abstract:

Refer to hard copy

Project Title:	Chiral Alcohol Catalyzed Asymmetric Oxidation Reactions
Investigator(s):	Toy PH
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2005

Abstract:

Oxidation is one of the fundamental chemical reactions/processes in nature and much of modern organic and inorganic chemistry has been devoted to the development of new methods for the oxidation of organic compounds such as alkenes and sulfides. In this regard, processes that can perform this reaction efficiently in an asymmetric sense are highly valued. Yet more value is added if the process is environmentally friendly, since many such reactions use polluting metal catalysts or produce ecologically undesired by-products. The objective of this proposed project is to develop a novel approach to such non-polluting, asymmetric alkene and sulphide oxidation that uses only a chiral alcohol solvent or catalyst as the source of asymmetry and the only by-product of which is water.

List of Research Outputs

But Y.S., Tashino Y., Togo H. and Toy P.H., A multipolymer system for organocatalytic alcohol oxidation, Organic and Biomolecular Chemistry. 2005, 3(6): 970-971.

Chung W.Y. and Toy P.H., A polystyrene-supported triflating reagent for the synthesis of aryl triflates, Tetrahedron. 2005, 61(3): 709-715.

Harned A.M., He S., Toy P.H., Flynn D.L. and Hanson P.R., Multipolymer solution-phase reactions: application to the mitsunobu reaction, Journal of the American Chemical Society. 2005, 127(1): 52-53.

He S., Chung W.Y., But Y.S. and Toy P.H., Arsonium ylides in organic synthesis, Tetrahedron. 2005, 61(6): 1385-1405.

He S., But Y.S. and Toy P.H., Polymer-supported triphenylamine, triphenylarsine and triphenylphosphine reagents, International Conference on Heteroatom Chemistry, Shanghai, China, August 21-25, 2004.

Kan T.W. and Toy P.H., Poly(ethylene glycol)-supported a,a,a-trifluoroacetophenone in dioxirane mediated alkene epoxidation reactions, Tetrahedron Letters. 2004, 45(33): 6357-6359.

Lau C.Y., He S., Chiu P. and Toy P.H., Polystyrene-supported triphenylarsine reagents and their use in Suzuki cross-coupling reactions, Journal of Combinatorial Chemistry. 2004, 6(6): 955-960.

Ma C., Zuo P., Kwok W.M., Chan W.S., Kan T.W., Toy P.H. and Phillips D.L., Time-resolved resonance raman study of the triplet states of p-hydroxyacetophenone and the p-hydroxyphenacyl diethyl phosphate phototrigger compound, Journal of Organic Chemistry. 2004, 69(20): 6641-6657.

Ma C., Kwok W.M., Chan W.S., Zuo P., Kan T.W., Toy P.H. and Phillips D.L., Ultrafast time-resolved study of photophysical processes involved in the photodeprotection of p-Hydroxyphenacyl caged phototrigger compounds, Journal of the American Chemical Society. 2005, 127(5): 1463-1472.

Toy P.H. and He S., Development of polymer-supported triphenylarsine and triphenylphosphine reagents, American Chemical Society National Meeting, San Diego, California, USA, March 13-17, 2005.

Toy P.H., JandaJel, Electronic Encyclopedis of Reagents for Organic Synthesis. U.K., Wiley, 2004, on-line publication.

Toy P.H., TeNtAgel, Electronic Encyclopedis of Reagents for Organic Synthesis. U.K., Wiley, 2004, on-line publication.

Zhao L.J., He S., Shi M. and Toy P.H., Polystyrene-supported phosphine-catalyzed aza-baylis-hillman reactions and the relationship between resin loading level and catalyst efficiency, Journal of Combinationial Chemistry. 2004, 6(5): 680-683.

Researcher : Tsang KY

List of Research Outputs

Zhang X., Tsang K.Y. and Chan G.K.Y., Electrocatalytic properties of supported platinum-cobalt nanoparticles with uniform and controlled composition, Journal of Electroanalytical Chemistry. 2004, 573: 1-9.

Researcher : Tse CW

List of Research Outputs

Chan W.K., Man K.K.Y., Wong H.L., Cheng K.W., Tse C.W. and Djurisic A., The use of metal-containing polymers as sensitizers in photovoltaic cells and photodetectors, The 5th Asian Photochemistry Conference (APC-5), Taipei, Taiwan, January 5-10. 2005.

Cheng K.W., Man K.K.Y., Tse C.W., Chan W.K. and Djurisic A., Fabrication of photovoltaic devices incorporated with cadmium sulfide nanoparticles by a multilayer deposition process, Materials Research Society 2004 Fall Meeting, Boston, USA, November 28-December 2, 2004.

Tse C.W., Cheng K.W., Chan W.K. and Djurisic A., Self-assembled monolayer formed by a rhenium complex containing hyperbranched polymer, Macromolecular Rapid Communications. WILEY-VCH Verlag GmbH & Co., 2004, 25: 1335-1339.

Tse C.W., Lam S.M.L., Man K.K.Y., Wong W.T. and Chan W.K., Synthesis and characterization of random and block copolymers with pendant rhenium diimine complexes by controlled radical polymerization, Journal of Polymer Science: Part A: Polymer Chemistry. 2005, 43: 1292-1308.

Researcher : Tse CW

List of Research Outputs

Researcher : Tse MK

List of Research Outputs

Guan X., Tse M.K., Yang Y., Sze K.H., Cheung K.K. and Wong K.B., Structure and dynamics of a thermophilic acylphosphatase from Pyrococcus horikoshii by NMR spectroscopy - structural basis of thermostability and enzymatic activities, Twelfth Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong, The City University of Hong Kong, 23 Apr. 2005. 43.

Sze K.H., Yang Y., Guan X., Tse M.K. and Barsukov I., Combined computational and experimental developments for automated determination of protein structures by NMR, XXI International Conference on Magnetic Resonance in Biologicall Systems, Hyderabad, India, 16-21 Jan, 2005. 94.

Sze K.H., Yang Y., Guan X., Tse M.K., Cheung K.K. and Wong K.B., Structure and dynamics of a thermophilic acylphosphatase from Pyrococcus horikoshii by NMR spectroscopy - structural basis of thermostability and enzymatic activities, XXI International Conference on Magnetic Resonance in Biologicall Systems, Hyderabad, India, 16-21 Jan, 2005. 155.

Tse M.K., Sze K.H., Lin D., Liu X. and Zhu G., Water accessibility perturbation: A novel protein-protein interaction mapping method by solvent exposed amides NMR experiment, The 12^th Symposium on Chemistry Postgraduate Research in Hong Kong, The City University of Hong Kong, Hong Kong, Apr 23,2005. 44.

Yang Y., Guan X., Tse M.K., Sze K.H. and Haynes R.K., Eluciation of solution conformations of loloatins by NMR spectroscopy, The 12^th Symposium on Chemistry Postgraduate Research in Hong Kong, The City University of Hong Kong, Hong Kong, Apr 23,2005. 45.

Researcher : Tsui WM

List of Research Outputs

He L., Chan P.W.H., Tsui W.M., Yu W.Y. and Che C.M., Ruthenium(II) porphyrin-catalyzed amidation of aromatic heterocycles , Organic Letters. 2004, 6: 2405-2408.

Researcher : Vellaisamy ALR

List of Research Outputs

Vellaisamy A.L.R., Zhi Y.G., Xu Z., Yu S., Chan P.W.H. and Che C.M., Functionalized arylacetylene oligomers for organic thin-film transistors (OTFTs), Advanced Materials. 2005, 17: 1258-1261.

Vellaisamy A.L.R., Member, SPIE, The International Society for Optical Engineering, USA. 2005.

Vellaisamy A.L.R., Photoluminescence and EPR of ZnO tetrapod structures, In: Wiley-VCH, Adv. Fun. Mat. 14(9), 856, 2004. Germany, Wiley-VCH, 2004, 14: 856.

Vellaisamy A.L.R., Tetracene based Organic Light-Emitting transistors: optoelectronic properties and electron injection mechanism, In: Elsevier, Synthetic Metals, 146, 329-334, 2004. Ireland, Elsevier, 2004, 146: 329-334.

Zheng R.K., Liu H., Zhang X.X., Vellaisamy A.L.R. and Djurisic A., Exchange bias and the origin of magnetism in Mn-doped ZnO tetrapods, Applied Physics Letters. New York, American Institute of Physics, 2004, 85: 2589-2591.

Researcher : Wang CC

Project Title:	Discovering new drug leads by combinatorial synthesis and protein chip-based mass spectrometry
Investigator(s):	Wang CC
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	10/2002
Completion Date:	09/2004

Abstract:

To harness the synergistic power of protein chip-based mass spectrometry and combinatorial chemistry in discovering small molecule ligands (drug leads) of proteins. As proof of principle, this combined tool will be used to search for new ligands of metabotropic glutamate receptors (mGluRs).

Project Title:	Using rationally designed substrate analogs to probe the nitric oxide synthase reaction
Investigator(s):	Wang CC
Department:	Chemistry
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2003

Abstract:

To use rationally designed substrate analogs to probe the reaction mechanism and the active site structure of the enzyme Nitric Oxide Synthase (NOS).

Project Title:	Investigating the nitric oxide synthase reaction using mechanism probes
Investigator(s):	Wang CC
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004
Completion Date:	02/2005

Abstract:

To characterize the reactivity of a variety of fluorine-containing mechanism probe molecules toward standard oxidation conditions; to investigate the enzymatic reaction products of NOS and NHA analogs containing the mechanism probes afore-mentioned.

Project Title:	Using Rationally Designed Substrate Analogs to Probe the Nitric Oxide Synthase Reaction
Investigator(s):	Wang CC
Department:	Chemistry
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2004

Abstract:

Refer to hard copy

Researcher : Wang D

List of Research Outputs

Guan X., Lin X., Kwok W.M., Du Y., Li Y., Zhao C., Wang D. and Phillips D.L., Ultraviolet photolysis of CH₂I₂ in ,methanol: O-H insertion and HI elimination reactions to form a dimethoxymethane product, Journal of Physical Chemistry A. 2005, 109(6): 1247-1256.

Phillips D.L., Kwok W.M., Zhao C., Guan X., Du Y., Li Y. and Wang D., Water assisted dehalogenation reactions of selected isopolyhalomethanes, halomethanols and haloformaldehydes, Abstract of 229^th ACS National Meeting, San Diego, California, U.S.A., March 13 - March 17, 2005. Phys. 2005.

Wang D., Zhao C. and Phillips D.L., Samarium(III) carbenoid as a competing reactive species in samarium-promoted cyclopropanation reactions, Journal of Organic Chemistry. 2004, 69: 5512-5515.

Zhao C., Lin X., Kwok W.M., Guan X., Du Y., Wang D., Hung K.F. and Phillips D.L., Water-catalyzed dehalogenation reactions of the isomer of CBr₄ and its reaction products and a comparison to analogous reactions of the isomers of d- and trihalomethanes, Chemistry - A European Journal. 2005, 11(4): 1093-1108.

Researcher : Wang H

List of Research Outputs

Liu J., Wang H., Cheng S. and Chan G.K.Y., Nafion-polyfurfuryl alcohol nanocomposite membranes for direct methanol fuel cells, Journal of Membrane Science . 2005, 246: 95-101.

Researcher : Wang H

Project Title:	Direct synthesis of template-free zeolite nanocrystals by using in situ polymer hydrogels
Investigator(s):	Wang H
Department:	Chemistry
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2003

Abstract:

To study direct synthesis of template-free zeolite nanocrystals by using in situ polymer hydrogels.

List of Research Outputs

Liu J., Wang H., Cheng S. and Chan G.K.Y., Nafion-polyfurfuryl alcohol nanocomposite membranes for direct methanol fuel cells, Journal of Membrane Science . 2005, 246: 95-101.

Researcher : Wang X

List of Research Outputs

Duan X.M., Song G.L., Li Z.H., Wang X., Chen G. and Fan K.N., Accurate prediction of heat of formation by combining Hartree-Fock/density functional theory calculation with linear regression correction approach, Journal of Chemical Physics. 2004, 121(15): 7086-7095.

Wang X., Wong L.H., Hu L., Chan C.Y., Su Z. and Chen G., Improving the accuracy of density-functional theory calculation: the statistical correction approach, Journal of Physical Chemistry A. 2004, 108(40): 8514-8525.

Yam C.Y., Ma C.C., Wang X. and Chen G., Electronic structure and charge distribution of potassium iodide intercalated single-walled carbon nanotubes, Applied Physics Letters. 2004, 85(19): 4484-4486.

Researcher : Wang Y

List of Research Outputs

Wang Y., He Q., Che C.M. and Chiu J., Gold porphyrin(III) 1a induced apoptosis through caspase-dependent and -independent mitochondrial death pathways regulated by reactive oxygen species, ASBMB Annual Meeting, SD, USA, April 16-21. 2005.

Wang Y., Chiu J. and He Q., Proteomics in computer-aided drug design, Current Computer-Aided Drug Design. 2005, 1: 43-52.

Wang Y., Ko C.B., Yang J.Y., Lam T.L., Jiang Z., Zhang Z., Chung S.K. and Chung S.S.M., Transgenic mice expressing dominant-negative osmotic-response element-binding protein (OREBP) in lens exhibit fiber cell elongation defect associated with increased DNA breaks, The Journal of Biological Chemistry. 2005, 280: 19986-199991.

Researcher : Wang Y

List of Research Outputs

Wang Y., Chiu J. and He Q., Proteomics in computer-aided drug design, Current Computer-Aided Drug Design. 2005, 1: 43-52.

Researcher : Wang Y

List of Research Outputs

Wang Y., Chiu J. and He Q., Proteomics in computer-aided drug design, Current Computer-Aided Drug Design. 2005, 1: 43-52.

Researcher : Wong CL

List of Research Outputs

Wong C.L., Mass spectrometric studies on protonated and alkali metal cationized amino acids and peptides(PhD). 2004.

Researcher : Wong CY

List of Research Outputs

Wong C.Y., Ruthenium-carbon bonding interaction: synthesis and spectroscopic studies of ruthenium-acetylide, -carbene, -vinylidene and -allenylidene complexes(PhD). 2005.

Researcher : Wong HL

List of Research Outputs

Chan W.K., Man K.K.Y., Cheng K.W., Wong H.L. and Djurisic A., Fabrication of organic photovoltaic devices by the layer-by-layer polyelectrolyte deposition method, 2004 Conference on Optoelectronic and Microelectronic Materials and Devices (COMMAD 2004), The University of Queensland, Brisbane, Australia, December 8-10, 2004.

Chan W.K., Man K.Y.K., Hui C.S. and Wong H.L., The use of metal containing polymers as photo-sensitizing materials, 15th International Symposium on Photophysics and Photochemistry of Coordination Compounds, Hong Kong, July 4-9, 2004.

Chan W.K., Man K.K.Y., Wong H.L., Cheng K.W., Tse C.W. and Djurisic A., The use of metal-containing polymers as sensitizers in photovoltaic cells and photodetectors, The 5th Asian Photochemistry Conference (APC-5), Taipei, Taiwan, January 5-10. 2005.

Wong H.L., Cheng K.W., Man K.Y.K., Kwong C.Y., Chan W.K. and Djurisic A., Fabrication of bulk heterojunction photovoltaic devices using sublimable rhenium diimine complexes as photosensitizers, Proceedings of SPIE. Bellingham, SPIE, 2004, 5520: 168-175.

Researcher : Wong JKY

Project Title:	Luminescent benzylic amide macrocycle-based metal complexes with potential sensing capabilities
Investigator(s):	Wong JKY, Yam VWW
Department:	Chemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To synthesise macrocycle-containing metal complexes; to add guest and test the benzylic amide macrocycle-based metal complexes as luminescent sensors.

List of Research Outputs

Tang H.S., Lu X., Ko C.C., Wong J.K.Y. and Yam V.W.W., First Observation of Ion-Induced Trans-Cis Isomerization of Palladium(II) Phosphine Complex Containing Various Receptor Sites, The XX IUPAC Symposium on Photochemistry, Granada, Spain (Poster presented by Miss Hau-San Tang). 2004.

Researcher : Wong KL

List of Research Outputs

Law G.L., Wong K.L., Zhou X.J., Wong W.T. and Tanner P.A., Crystal structure and luminescence of lanthanide monodentate complexes [Ln(C₄N₄H₆O)₂(H₂O)₆]Cl₃ and [Ln(C₄N₄H₆O)₂(H₂O)₃(NO₃)₃](Ln=Tb or Eu), Inorganic Chemistry. 2005, 44: 4142-4144.

Luo L., Lai P.W., Wong K.L., Wong W.T., Li K.F. and Cheah K.W., Green upconversion fluorescence in terbium coordination complexes, Chemical Physics Letters. 2004, 398: 372-376.

Wong K.L., Kwok W.M., Wong W.T., Phillips D.L. and Cheah K.W., Green and red three-photon upconversion from polymeric lanthanide(III) complexes, Angewandte Chemie International Edition. 2004, 43(35): 4659-4662.

Wong K.L., Law G.L., Kwok W.M., Wong W.T. and Phillips D.L., Simultaneous observation of green multiphoton upconversion and red and blue NLO processes from polymeric terbium(III) complexes, Angewandte Chemie International Edition. 2005, 44: 3436-3439.

Researcher : Wong KW

List of Research Outputs

Ko C.B., Wong K.W., Chiu P., Chung S.S.M., Chow L.M. and Yang B.B., Pseudolaric acid B as a new class of microtubule destabilizing agent and an effective anti-tumor compound in vivo, Abstract of 44^th Annual Meeting of The American Society for Cell Biology, Washington Convention Center, Washington, DC, U.S.A. December 4-8,2004.

Li Z., Liao C., Ko C.B., Shan S., Tong H.Y., Yin Z., Pan D., Wong K.W., Shi L., Ning Z.Q., Hu W., Zhou J., Chung S.S.M. and Lu X.P., Design, synthesis, and evaluation of a new class of noncyclic 1,3-dicarbonyl compounds as PPARa selective activators, Bioorganic & Medicinal Chemistry Letters . 2004, 14: 3507-3511.

Liu Y., Wong K.W., Ko C.B., Wong M.K. and Che C.M., Synthesis and cytotoxicity studies of artemisinin derivatives containing lipophilic alkyl carbon chains, Organic Letters. 2005, 7: 1561-1564.

Researcher : Wong KY

List of Research Outputs

Lu X., Tang H.S., Ko C.C., Wong K.Y., Zhu N. and Yam V.W.W., Anion-assisted trans-cis isomerization of palladium(II) phosphine complexes containing acetanilide functionalities through hydrogen bonding interactions, Chemical Communications. 2005, 1572-1574.

Researcher : Wong LH

List of Research Outputs

Wang X., Wong L.H., Hu L., Chan C.Y., Su Z. and Chen G., Improving the accuracy of density-functional theory calculation: the statistical correction approach, Journal of Physical Chemistry A. 2004, 108(40): 8514-8525.

Researcher : Wong LME

List of Research Outputs

Yang Z., Wong L.M.E., Shum Y.T., Che C.M. and Hui Y., Fluorophore-appended steroidal saponin (Dioscin and Polyphyllin D) derivatives, Organic Letters. 2005, 7: 669-672.

Researcher : Wong MC

List of Research Outputs

Chan H.Y., Wong M.C. and Yam V.W.W., Effect of Molecular Environmental Changes on the Aggregation and Photophysical Behavior of Novel Platinum(II) Alkynyl Complexes, The XX IUPAC Symposium on Photochemistry, Granada, Spain (Poster presented by Mr. Kenneth Hoi-Yiu Chan). 2004.

Chan H.Y., Wong M.C. and Yam V.W.W., Effect of molecular environmental changes on the aggregation and photophysical behavior of novel platinum(II) alkynyl complexes, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Mr. Kenneth Hoi Yiu Chan). 2004, P-4.

Lam C.F., Wong M.C., Zhu N., Yam V.W.W., Roué S., Lapinte C., Fathallah S., Costuas K., Kahlal S. and Halet J.F., Electro-swithchable photoluminescence of rhenium-iron mixed-metal alkynyl complexes, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Miss Sally Chan Fung Lam). 2004, P-31.

Li C.K., Lu X., Wong M.C., Chan C.L., Zhu N. and Yam V.W.W., Molecular design of luminescence ion probes for various cations based on weak gold(I)...gold(I) interactions in dinuclear gold(I) complexes, Inorganic Chemistry. 2004, 43(23): 7421-7430.

Tang W.S., Wong M.C., Lu X., Zhu N. and Yam V.W.W., Functionalized Platinum(II) Alkynyl Complexes as Colorimetric and Luminescence pH Sensors, The XX IUPAC Symposium on Photochemistry, Granada, Spain (Poster presented by Miss Wing-Suen Tang). 2004.

Tang W.S., Wong M.C., Lu X., Zhu N. and Yam V.W.W., Functionalized platinum(II) alkynyl complexes as colorimetric and luminescence _pH and ion sensors, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Miss Wing Suen Tang). 2004, P-57.

Tao C.H., Wong M.C., Zhu N. and Yam V.W.W., Synthesis, structural characterisation and electrochemical studies of luminescent carbazole-containing platinum(II) and palladium(II) alkynyl complexes, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Mr. Chi Hang Tao). 2004, P-59.

Wong M.C., Zhu X., Hung L.L., Zhu N., Yam V.W.W. and Kwok H.S., A novel class of phosphorescent gold(III) alkynyl-based organic light emitting devices with tunable color, Chemical Communications. 2005, 2906-2908.

Wong M.C., Tang W.S., Lu X., Zhu N. and Yam V.W.W., Functionalized platinum(II) terpyridyl alkynyl complexes as colorimetric and luminescence pH sensors, Inorganic Chemistry. 2005, 44(5): 1492-1498.

Wong M.C., Photophysical and Aggregation Studies of Luminescent Organoplatinum(II) Terpyridyl Complexes, 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds. 2004.

Wong M.C., Chan H.Y., Yu C. and Yam V.W.W., Photophysical and aggregation studies of luminescent organoplatinum(II) terpyridyl complexes, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Dr Keith Man Chun Wong). 2004, 0-8.

Wong M.C., Tang W.S., Chu B.W.K., Zhu N. and Yam V.W.W., Synthesis, photophysical properties, and biomolecular labeling studies of luminescent platinum(II)-terpyridyl alkynyl complexes, Organometallics. 2004, 23(14): 3459-3465.

Wong M.C., Li W., Cheung K.K. and Yam V.W.W., Synthesis, photophysics, electrochemistry and metal ion-binding studies of rhenium(I) complexes with crown ether pendants:selective and specific binding properties for various metal ions, New Journal of Chemistry. 2005, 29: 165-172.

Yam V.W.W., Wong M.C., Hung L.L. and Zhu N., Unprecedented luminescent gold(III) alkynyl complexes - synthesis, structural characterization and luminescent properties, Angewandte Chemie International Edition. 2005, 44: 3107-3110.

Yu C., Wong M.C., Chan H.Y. and Yam V.W.W., Polymer-induced self-assembly of alkynylplatinum(II) terpyridyl complexes via metal...metal/p...pinteractions, Angewandte Chemie International Edition. 2005, 44: 791-794.

Researcher : Wong MK

List of Research Outputs

Chan W.K., Wong M.K. and Che C.M., Metalloporphyrin-catalyzed diasteroselective epoxidation of allyl-substituted alkenes, The Journal of Organic Chemistry. 2005, 70: 4226-4232.

Ho C.Y., Chen Y., Wong M.K. and Yang D., Fluorinated chiral secondary amines as catalysts for epoxidation of olefins with oxone, The Journal of Organic Chemistry. 2005, 70: 898-906.

Liu Y., Wong K.W., Ko C.B., Wong M.K. and Che C.M., Synthesis and cytotoxicity studies of artemisinin derivatives containing lipophilic alkyl carbon chains, Organic Letters. 2005, 7: 1561-1564.

Researcher : Wong MY

List of Research Outputs

Ma T., Li L., Leung W.H., Wong M.Y. and Cheung A.S.C., Cavity ring-down laser absorption spectroscopy of yttrium and nickel monoiodides, 60th Ohio State University International Symposium on Molecular Spectroscopy, U.S.A., June 20-24. 2005, FB05.

Researcher : Wong WT

Project Title:	Relaxometric and stability studies of binuclear gadolinium complexes of cyclic polyaminocarboxylate ligands
Investigator(s):	Wong WT
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2002

Abstract:

This project aims at developing new binuclear gadolinium (Gd) complexes with high water proton relaxivity, good thermodynamic stability, and high in vivo specificity.

Project Title:	Synthesis and reactivity of osmium carbonyl clusters containing oxime ligands
Investigator(s):	Wong WT
Department:	Chemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002
Completion Date:	10/2004

Abstract:

To develop synthetic methods for osmium clusters containing oxime ligands; to investigate the chemical reactivity of cluster-bound oximes.

Project Title:	Coordination polymers of transition metals and lanthanide metals
Investigator(s):	Wong WT
Department:	Chemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To establish new synthetic routes to metal coordination polymers; to investigate the 3-D structures of these new metal containing polymers; to study the small molecule inclusion properties of these materials.

Project Title:	High nuclearity mixed-metal clusters and bimetallic nanoparticles of palladium and osmium
Investigator(s):	Wong WT
Department:	Chemistry
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	12/2003

Abstract:

To establish new synthetic routes to high nuclearity palladium and osmium carbonyl clusters; to determine their physical and chemical properties; to develop methods for the preparing of bimetallic nanoparticles on solid supports from these metal cluster precursors; to examine the potential applications of the bimetallic nanoparticles in catalysis.

Project Title:	High nuclearity mixed-metal clusters and bimetallic nanoparticles of palladium and osmium
Investigator(s):	Wong WT
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	12/2003

Abstract:

Project Title:	Gadolinium Complexes of Functionalised Tetraazacyclodedecane Ligands: Magnetic Resonance Imaging Contrast agents
Investigator(s):	Wong WT
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2004

Abstract:

To design and prepare new gadolinium (Gd) complexes containing functionalised tetraazacyclodedecane (cyclen) ligands; to study their structures in both the solid-state and in solution; to investigate the relaxivity and thermodynamic stability of these new Gd complexes in water; to carry out in vivo magnetic resonance imaging using these Gd complexes on rats; to evaluate the potential applications of these new complexes as contrast enhancing agents in magnetic resonance imaging (MRI).

Project Title:	Synthesis and properties of lanthanide polyamido complexes
Investigator(s):	Wong WT
Department:	Chemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To establish new synthetic methods to lanthanide complexes containing amido ligands; to characterize these new compounds by spectroscopic and crystallographic methods; to investigate the chemical and photochemical properties of these new materials.

Project Title:	Gadolinium Complexes of Functionalised Tetraazacyclodedecane Ligands: Magnetic Resonance Imaging Contrast agents
Investigator(s):	Wong WT
Department:	Chemistry
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

List of Research Outputs

Bera M., Wong W.T., Aromi G., Ribas J. and Ray D., A novel m₄-oxo bridged copper tetrahedron derived by self-assembly:First example of double helical bis(tridentate) coordination of a hexadentate amine phenol ligand, Inorganic Chemistry. 2004, 43: 4787-4789.

Bera M., Ribas J., Wong W.T. and Ray D., A chair-piperazine bridged N,N-dimethylformamide coordinated dicopper(II/II) complex obtained via solution transformation of heterocyclic imidazolidine spacer of a new ligand, Inorganic Chemistry Communications. 2004, 7: 1242-1245.

Bera M., Wong W.T., Aromi G. and Ray D., m-h¹:h¹-N,N'-Imidazolidine-bridged Dicopper (II/III) complexes of a new dinucleating m-Bis(tetradentate) schiff base ligand: synthesis, structural characterization, ¹H NMR spectroscopy, and magnetic coupling, European Journal of Inorganic Cheimstry. 2005, 2526-2535.

Chan W.K., Lam T.W., Law W.S., Wong W.T., Koo M.W.L., Lau A.S.Y., Lau Y.L. and Chan G.C.F., Ganoderma Lucidum mycelium extract can enhance maturation of monocyte-derived dendritic cells without inducing significant allogenic immune response in vitro, Joint Annual Scientific Meeting 2004, The Hong Kong Paediatric Society, Hong Kong, 27 November 2004. 55.

Lau M.K., Cheung K.M., Zhang Q.F., Song Y.L., Wong W.T., Williams I.D. and Leung W.H., Iridium(III) and rhodium(III) cyclometalated complexes containing sulfur and selenium donor ligands, Journal of Organometallic Chemistry. 2004, 689: 2401-2410.

Lau P.H., Yeung W.F., Man W.L., Lau T.C., Wei H.Y., Sun H.L., Gao S., Chen Z.D. and Wong W.T., [Ru(salen)(CN)2]- and [Ru(acac)2(CN)2]- as building blocks : Syntheses, structures and magnetic properties of heterobimetallic MRu2 compounds., Abstracts of 229th ACS national meeting, San Diego, CA, United States, March 13-17,2005. American Chemical Society, INOR-144, U983.

Law G.L., Wong K.L., Zhou X.J., Wong W.T. and Tanner P.A., Crystal structure and luminescence of lanthanide monodentate complexes [Ln(C₄N₄H₆O)₂(H₂O)₆]Cl₃ and [Ln(C₄N₄H₆O)₂(H₂O)₃(NO₃)₃](Ln=Tb or Eu), Inorganic Chemistry. 2005, 44: 4142-4144.

Lee W.S., Leung H.K., Cheng L.S., Ng L.Y., Lee C.S., Huang K.H., Wong W.T. and Kwong H.L., Chiral 2-pyridyl alcoholate copper complexes: crystal structures of [bis(2-pyridyl alcoholate)copper(II)] and the use of [(2-pyridyl alcoholate)copper(II)]⁺ and [(2-pyridyl alcoholate)copper(I)] in asymmetric cyclopropanation of styrene and allylic oxidation of cyclohexene, Inorganica Chimica Acta. 2004, 357: 4389-4395.

Leung C.F., Wong T.W., Lau T.C. and Wong W.T., Addition of carbenes to an osmium(VI) nitride complex, European Journal of Inorganic Chemistry. 2005, 773-778.

Li C., Law G.L. and Wong W.T., Luminescent Tb³⁺ complex with pendant crown ether showing dual-component recognition of H⁺ and K⁺ at multiple pH windows, Organic Letters. 2004, 6(26): 4841-4844.

Li C. and Wong W.T., Luminescent heptadentate Tb³⁺ complex with pendant aza-15-crown-5 showing recognition of lactate and salicylate in aqueous solution, Tetrahedron Letters. 2004, 45: 6055-6058.

Luo L., Lai P.W., Wong K.L., Wong W.T., Li K.F. and Cheah K.W., Green upconversion fluorescence in terbium coordination complexes, Chemical Physics Letters. 2004, 398: 372-376.

Shek I.P.Y., Yeung W.F., Lau T.C., Zhang J., Gao S., Sze-To L. and Wong W.T., Ni^IIRu^II and Cu^IIRu^II coordination polymers constructed from [Ru(CN)₆]^4-, European Journal of Inorganic Chemistry. 2005, 364-370.

Shek L., Shek P.Y., Lau T.C. and Wong W.T., Syntheses and characterizations of ruthenium complexes containing pyrazole ligands, Abstracts of 229th ACS national meeting, San diego, CA, United States, March 13-17,2005. American Chemical Society, INOR-324, U1011.

Tse C.W., Lam S.M.L., Man K.K.Y., Wong W.T. and Chan W.K., Synthesis and characterization of random and block copolymers with pendant rhenium diimine complexes by controlled radical polymerization, Journal of Polymer Science: Part A: Polymer Chemistry. 2005, 43: 1292-1308.

Wong K.L., Kwok W.M., Wong W.T., Phillips D.L. and Cheah K.W., Green and red three-photon upconversion from polymeric lanthanide(III) complexes, Angewandte Chemie International Edition. 2004, 43(35): 4659-4662.

Wong K.L., Law G.L., Kwok W.M., Wong W.T. and Phillips D.L., Simultaneous observation of green multiphoton upconversion and red and blue NLO processes from polymeric terbium(III) complexes, Angewandte Chemie International Edition. 2005, 44: 3436-3439.

Wong W.T., Co-Editor of Acta Crystallographica Section E, International Union of Crystallography (1/7/2004-30/6/2005). 2004.

Yang C., Fu L.M., Wang Y., Zhang J.P., Wong W.T., Ai X.C., Qiao Y.F., Zou B.S. and Gui L.L., A highly luminescent europium complex showing visible-light-sensitized red emission: Direct observation of the singlet pathway, Angewandte Chemie (International Ed). 2004, 43: 5010-5013.

Yang C. and Wong W.T., Self-assembly of guanidinium hexagonal carboxylate: How many H-bonds and H-bonding pattern between ArCOO^- and C(NH₂)₃⁺, Chemistry Letters. 2004, 33: 856-857.

Yang Y., Huang Z.Q., Chen X.M., Wong W.T. and Ng S.W., Diiodobis (2-hydroxymethyl-1-methyl-1-imidazole-N³)cadmium(II), Applied Organometallic Chemistry. 2005, 19: 354-355.

Yang Y., Sze-To L., Ouyang G.F., Huang Z.Q., Wong W.T. and Ng S.W., m₂Diiodotetrakis(2-hydroxymethyl-1-methyl-1-imidazole-N³)dicadmium(II) bis[triiodo(2-hydroxymethyl-1-methyl-1-imidazole-N³)cadmate(II)] dihydrate, Applied Organometallic Chemistry. 2005, 19: 352-353.

Yeung C.T., Kwong H.L. and Wong W.T., Synthesis of chiral terpyridine cobalt(II) complexes and their use in catalytic asymmetric cyclopropanation, Abstracts of 228th ACS National Meeting, Philadelphia, PA, United States, August 22-26, 2004. American Chemical Society, INOR-119, U794.

Zhang Z.Q., Yao Y.M., Zhang Y., Shen Q. and Wong W.T., Synthesis, characterization and structural diversity of lanthanide chlorides supported by the b-diketiminate ligand [{2,6-Me₂C₆H₃)NC(Me)}₂CH]^-, Inorganica Chimica Acta. 2004, 357: 3173-3180.

Researcher : Wu L

List of Research Outputs

Ko C.C., Wu L., Zhu N. and Yam V.W.W., Synthesis, photochromic and luminescence switching properties of photochromic rhenium(I) complexes, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Dr. Chi Chiu Ko). 2004, 0-17.

Researcher : Xie J

List of Research Outputs

Xie J., Huang J.S., Zhu N., Zhou Z.Y. and Che C.M., Primary and secondary phosphane complexes of metalloporphyrins: isolation, spectrocscopy, and x-ray crystal structures of ruthenium and osmium porphyrins binding phenyl- or diphenylphosphane, Chemistry - A European Journal. 2005, 11: 2405-2416.

Researcher : Xu Z

List of Research Outputs

Vellaisamy A.L.R., Zhi Y.G., Xu Z., Yu S., Chan P.W.H. and Che C.M., Functionalized arylacetylene oligomers for organic thin-film transistors (OTFTs), Advanced Materials. 2005, 17: 1258-1261.

Researcher : Yam CY

List of Research Outputs

Yam C.Y., Ma C.C., Wang X. and Chen G., Electronic structure and charge distribution of potassium iodide intercalated single-walled carbon nanotubes, Applied Physics Letters. 2004, 85(19): 4484-4486.

Researcher : Yam VWW

Project Title:	Transition metal complexes with alkynyl-containing moieties as building blocks for metal-based materials with luminescence and/or chemosensing capabilities
Investigator(s):	Yam VWW
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	08/2000
Completion Date:	07/2004

Abstract:

To start the construction of carbon-rich metal-containing materials with two- or three-dimensional networks in a controlled fashion by employing highly branched alkynyl building blocks.

Project Title:	Strategies towards the molecular design of novel metalloreceptors
Investigator(s):	Yam VWW
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	08/2001
Completion Date:	07/2004

Abstract:

To design, synthesize, and characterize various functional organic ligands containing receptor or latent (precursor) receptor sites; to incorporate the newly synthesized ligands into variou transition metal centres of selected metals and to characterize the metal complexes formed; to investigate the spectroscopic, luminescence, photochromic and photophysical properties, if any, of selected metal complexes; to explore their potential for applications as spectrochemical and/or luminescence metalloreceptors for substrates of biological and environmental interests.

Project Title:	Synthetic design of molecular switches based on ion-/redox-induced processes
Investigator(s):	Yam VWW
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2002

Abstract:

The project attempts to develop two new approaches for the design of new classes of molecular switches. The first approach involves the rational molecular design and synthesis of square planar metal complexes and the utilization of ion-binding to bring about reversible trans-cis geometrical isomerization reactions of these complexes. The second approach employs an alternative new concept of a redox-induced 'link-delink' comformational change involving an S-S bridge in the macrocyclic functional ligand framework to influence the electronic interaction or communication between two metal centres through the macrocyclic bridging ligand in the presence of the S-S bridge ('link' state) and in the absence of the S-S bridge ('delink' state).

Project Title:	Synthesis and aggregation studies of Platinum(II) complexes in various media and environments
Investigator(s):	Yam VWW
Department:	Chemistry
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	08/2003

Abstract:

To design, synthesize, and characterize various tridentate organic ligands; to incorporate the newly synthesized ligands into platinum metal centres and to characterize the metal complexes formed; to investigate the spectroscopic, electronic absorption, emission, and electrochemical properties of these platinum (II) complexes; to study the aggregation behaviour of these complexes in various solvent environments and microenvironments and to investigate the effects of environments on the electronic absorption and emission properties of these metal complexes; to explore and assess their potential for application as reporter of various environments.

Project Title:	Synthesis and aggregation studies of Platinum(II) complexes in various media and environments
Investigator(s):	Yam VWW
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	08/2003

Abstract:

Project Title:	Synthesis and immobilization of luminescent metal complexes for the fabrication of single-layer luminescence sensing devices
Investigator(s):	Yam VWW
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004
Completion Date:	01/2005

Abstract:

To contribute not only to the basic understanding of the optical and sensing behaviour of the newly prepared molecules, but also to the advancement and future development of new types of coordinating ligands and metal complexes for the immobilization and fabrication of single-layer sensing devices; to represents a new research initiative and effort in the investigation of the various immobilization techniques for the design and fabrication of new classes of single-layer sensing devices.

Project Title:	Design and Synthetic Strategies Towards Novel Classes of Photochromic Metal-Containing Compounds
Investigator(s):	Yam VWW
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	10/2004

Abstract:

To design, synthesize, and characterize various functionalized diarylethene ligands; to incorporate the newly synthesized ligands into selected metal centers and to characterize the metal complexes formed; to investigate the spectroscopic, electronic absorption, emission, and photochromic properties of the newly synthesized ligands and their metal complexes; to correlate their measured optical and photochromic properties as well as the thermal stabilities of their photocyclized forms with the electronic and structural aspects of the diarylethenes and the metal complexes.

Project Title:	Synthesis and Structure of Luminescent Redox-Active Carbon-Rich Mixed-Metal Complexes of Iron(II), Rhenium(I), and Platinum(II) -- From Molecules Towards Multi-Functional Molecular Devices
Investigator(s):	Yam VWW, Lapinte C., Wong K.M.C., Halet J.
Department:	Chemistry
Source(s) of Funding:	France/Hong Kong Joint Research Scheme - Travel Grants
Start Date:	01/2005

Abstract:

To synthesis various luminescent redox-active carbon-rich mixed-metal complexes of iron(II), rhenium(I) and platinum(II); to characterize the newly synthesized mixed-metal complexes structurally and spectroscopically; to investigate their spectroscopic, electrochemical, and luminescent behaviour, and to fabricate luminescent redox-active molecular device; to study the electronic structures of these complexes by means of density functional theory method; and to correlate their physical properties with the results obtained from theoretical studies.

Project Title:	Design and Synthetic Strategies Towards Novel Classes of Photochromic Metal-Containing Compounds
Investigator(s):	Yam VWW
Department:	Chemistry
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

Project Title:	Synthesis of anionic ruthenium crown-containing complexes and their applications in separation and indirect photometric detection of analytes in HPLC
Investigator(s):	Yam VWW
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2005
Completion Date:	10/2005

Abstract:

refer hard copy proposal

Project Title:	A proposal submitted to URC for seed funding under the research theme on organic optoelectronics
Investigator(s):	Yam VWW, Che CM, Lai PT, Xu SJ, Djurisic A, Chan WK
Department:	Chemistry
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	05/2005

Abstract:

To identify and build on existing strengths and efforts of research in HKU a multiplinary collaborative research team towards developing world-cleass excellence in organic optoelectronics research through the integration of research expertise and efforts in chemistry, physics and engineering. To accelerate and foster interdisciplinary research between the fields of chemistry, physics, and engineering. To establish HKU as a leading research center in materials for organic optoelectronic applications through innovative materials design and identification of novel device applications towards developing an internationally eminent research center and to advocate world-class research in the areas at HKU.

List of Research Outputs

Chan H.Y., Wong M.C. and Yam V.W.W., Effect of Molecular Environmental Changes on the Aggregation and Photophysical Behavior of Novel Platinum(II) Alkynyl Complexes, The XX IUPAC Symposium on Photochemistry, Granada, Spain (Poster presented by Mr. Kenneth Hoi-Yiu Chan). 2004.

Chan H.Y., Wong M.C. and Yam V.W.W., Effect of molecular environmental changes on the aggregation and photophysical behavior of novel platinum(II) alkynyl complexes, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Mr. Kenneth Hoi Yiu Chan). 2004, P-4.

Cheng C.C., Lo W.Y., Zhu N. and Yam V.W.W., Luminescent soluble polynuclear gold(I) chalcogenido aggreates-syntheses, characterization and photophysics, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Dr. Eddie Chung Chin Cheng). 2004, P-9.

Cheung K.L., Yip S.K. and Yam V.W.W., Synthesis, characterization, electrochemistry and luminescence studies of heterometallic gold(I)-rhenium(I) alkynyl complexes, Journal of Organometallic Chemistry. 2004, 689(24): 4451-4462.

Chong H.F., Lam C.F., Yam V.W.W., Zhu N., Cheung K.K., Fathallah S., Costuas K. and Halet J.F., Luminescent heterometallic branched alkynyl complexes of rhenium(I) - palladium(II): potential building blocks for heterometallic metallodendrimers, Organometallics. 2004, 23(21): 4924-4933.

Chong H.F., Lam C.F., Ko C.C. and Yam V.W.W., Synthesis, characterization and luminescence studies of trinuclear rhenium-cobalt mixed-metal alkynyl complexes containing a tetrahedral Co₂C₂ cluster unit¹, Journal of Cluster Science. 2004, 15(3): 301-314.

Chu B.W.K. and Yam V.W.W., Luminescent metal complexes as labels for biomolecules and candidates for photodynamic therapy, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Dr. Ben Wai Kin Chu). 2004, P-10.

Ko C.C., Wu L., Zhu N. and Yam V.W.W., Synthesis, photochromic and luminescence switching properties of photochromic rhenium(I) complexes, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Dr. Chi Chiu Ko). 2004, 0-17.

Lam C.F., Wong M.C., Zhu N., Yam V.W.W., Roué S., Lapinte C., Fathallah S., Costuas K., Kahlal S. and Halet J.F., Electro-swithchable photoluminescence of rhenium-iron mixed-metal alkynyl complexes, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Miss Sally Chan Fung Lam). 2004, P-31.

Lam C.F., Chong H.F., Cheung K.K. and Yam V.W.W., Luminescent rhenium(I) complexes with linear and hyperbranched alkynyl ligands, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Miss Sally Chan Fung Lam). 2004, P-30.

Li C.K., Lu X., Wong M.C., Chan C.L., Zhu N. and Yam V.W.W., Molecular design of luminescence ion probes for various cations based on weak gold(I)...gold(I) interactions in dinuclear gold(I) complexes, Inorganic Chemistry. 2004, 43(23): 7421-7430.

Lo W.Y., Lam C.M., Zhu N. and Yam V.W.W., Synthesis and luminescence behaviour of mixed-metal rhenium(I)-copper(I) and -silver(I) alkynyl complexes, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Miss Wing Yin Lo). 2004, P-39.

Lu X., Tang H.S., Ko C.C., Wong K.Y., Zhu N. and Yam V.W.W., Anion-assisted trans-cis isomerization of palladium(II) phosphine complexes containing acetanilide functionalities through hydrogen bonding interactions, Chemical Communications. 2005, 1572-1574.

Tang H.S., Lu X., Ko C.C., Wong J.K.Y. and Yam V.W.W., First Observation of Ion-Induced Trans-Cis Isomerization of Palladium(II) Phosphine Complex Containing Various Receptor Sites, The XX IUPAC Symposium on Photochemistry, Granada, Spain (Poster presented by Miss Hau-San Tang). 2004.

Tang H.S., Lu X., Ko C.C. and Yam V.W.W., Synthesis, luminescence and ion-induced trans-cis isomerization of palladium(II) phosphine complexes containing various receptor sites, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Miss Hau San Tang). 2004, P-56.

Tang W.S., Wong M.C., Lu X., Zhu N. and Yam V.W.W., Functionalized Platinum(II) Alkynyl Complexes as Colorimetric and Luminescence pH Sensors, The XX IUPAC Symposium on Photochemistry, Granada, Spain (Poster presented by Miss Wing-Suen Tang). 2004.

Tang W.S., Wong M.C., Lu X., Zhu N. and Yam V.W.W., Functionalized platinum(II) alkynyl complexes as colorimetric and luminescence _pH and ion sensors, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Miss Wing Suen Tang). 2004, P-57.

Tao C.H., Zhu N. and Yam V.W.W., Room-temperature phosphorescence and energy transfer in luminescent multinuclear platinum(II) complexes of branched alkynyls, Chemistry - A European Journal. 2005, 11: 1647-1657.

Tao C.H., Wong M.C., Zhu N. and Yam V.W.W., Synthesis, structural characterisation and electrochemical studies of luminescent carbazole-containing platinum(II) and palladium(II) alkynyl complexes, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Mr. Chi Hang Tao). 2004, P-59.

Wong M.C., Zhu X., Hung L.L., Zhu N., Yam V.W.W. and Kwok H.S., A novel class of phosphorescent gold(III) alkynyl-based organic light emitting devices with tunable color, Chemical Communications. 2005, 2906-2908.

Wong M.C., Tang W.S., Lu X., Zhu N. and Yam V.W.W., Functionalized platinum(II) terpyridyl alkynyl complexes as colorimetric and luminescence pH sensors, Inorganic Chemistry. 2005, 44(5): 1492-1498.

Wong M.C., Chan H.Y., Yu C. and Yam V.W.W., Photophysical and aggregation studies of luminescent organoplatinum(II) terpyridyl complexes, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Dr Keith Man Chun Wong). 2004, 0-8.

Wong M.C., Tang W.S., Chu B.W.K., Zhu N. and Yam V.W.W., Synthesis, photophysical properties, and biomolecular labeling studies of luminescent platinum(II)-terpyridyl alkynyl complexes, Organometallics. 2004, 23(14): 3459-3465.

Wong M.C., Li W., Cheung K.K. and Yam V.W.W., Synthesis, photophysics, electrochemistry and metal ion-binding studies of rhenium(I) complexes with crown ether pendants:selective and specific binding properties for various metal ions, New Journal of Chemistry. 2005, 29: 165-172.

Yam V.W.W., 6-hour lecture series on “Photochemistry and Luminescent Metal-Based Materials” under the theme Molecular-based Functional Materials, National Chemistry Summer School at Peking University organized for selected graduate students from major universities in China, sponsored by the Ministry of Education and National Natural Science Foundation of China, Beijing, July 2003 (re-scheduled to August 2004) (Invited Lecture). 2004.

Yam V.W.W., Centenary Lectureship, Royal Society of Chemistry. 2005.

Yam V.W.W., Department of Chemistry, Beijing Normal University (Invited Lecture). 2004.

Yam V.W.W., Department of Chemistry, University of Rennes, CNRS, France (Invited Lecture). 2005.

Yam V.W.W., Editorial Board (2005-07), Journal of Cluster Science. Springer Publisher, 2005.

Yam V.W.W., From simple molecules to molecular functional materials and nanoscience, the First National Natural Science Foundation of China Badaguan Conference on Nano- and Bio- Sciences, Qingdao, PR China (Invited lecture). 2005.

Yam V.W.W., International Editorial Board (2004-06), Coordination Chemistry Reviews. Elsevier Science, 2005.

Yam V.W.W., International Editorial Board (2005-present), Comments on Inorganic Chemistry. Taylor & Francis, 2005.

Yam V.W.W., Luminescent Metal Complexes – From design to assembly of molecular functional materials and chemosensors, the Symposium on Polymer and Molecular Electronics and Devices, Singapore (Invited lecture). 2005.

Yam V.W.W., Luminescent Metal-Based Molecular Materials - From fundamentals to applications, Sino-French Symposium for Advanced Chemistry and its Applications (SFSACA), Xiamen, PR China (Invited lecture). 2004.

Yam V.W.W., Luminescent Metal-Based Molecular Materials - From fundamentals to functions, Xiangshan Science Conference on Functional Supramolecular Systems: Micro- and Nano-Structures as Tools for Materials Science and Biotechnology (XSCSS 2004), Changchun, PR China (Invited lecture). 2004.

Yam V.W.W., Luminescent metal alkynyls – From design to assembly of molecular functional materials and chemosensors, the symposium entitled “Organic and Nanocomposite Optical Materials” at the 2004 Materials Research Society (MRS) Fall Meeting, Boston, USA (Invited lecture). 2004.

Yam V.W.W., Luminescent metal alkynyls – From simple molecules to molecular materials and chemosensors, the XXIst International Conference on Organometallic Chemistry (ICOMC), Vancouver, Canada (Sessional Lecture). 2004.

Yam V.W.W., Luminescent properties of metal alkynyls and their functions, the symposium entitled “Frontiers of Inorganic Photochemistry and Spectroscopy” at the 229th National Meeting of the American Chemical Society, San Diego, USA (Invited lecture). 2005.

Yam V.W.W., Ko C.C. and Zhu N., Photochromic and luminescence switching properties of a versatile diarylethene-containing 1, 10-phenanthroline ligand and its rhenium(I) complex, Journal of the American Chemical Society. 2004, 126(40): 12734-12735.

Yam V.W.W., Symposium on New Developments in Metal Alkynyl Chemistry (MC2R2004), Canberra, Australia (declined) (Invited main lecture). 2004.

Yam V.W.W., Cheung K.L., Yip S.K. and Zhu N., Synthesis, characterization, electrochemistry and luminescence studies of 9-anthrylgold(I) complexes, Photochemical and Photobiological Sciences. 2005, 4: 149-153.

Yam V.W.W., The 13th National Symposium on Organometallic Chemistry, Beijing (Plenary Lecture). 2004.

Yam V.W.W., The First Changchun Chemistry Week, Jilin University, Changchun (declined) (Invited Lecture). 2004.

Yam V.W.W., The First National Natural Science Foundation of China Conference on Nano- and Bio- Sciences, Qingdao, PR China (Invited Lecture). 2005.

Yam V.W.W., The Sino-French Symposium for Advanced Chemistry and its Applications (SFSACA), Xiamen, PR China (Invited Lecture). 2004.

Yam V.W.W., The Symposium on Polymer and Molecular Electronics and Devices, Singapore (Invited Lecture). 2005.

Yam V.W.W., The XXIst International Conference on Organometallic Chemistry (ICOMC), Vancouver, Canada (Invited Sessional Lecture). 2004.

Yam V.W.W., The Xiangshan Science Conference on Functional Supramolecular Systems: Micro- and Nano-Structures as Tools for Materials Science and Biotechnology (XSCSS 2004), Changchun, PR China (Invited Lecture). 2004.

Yam V.W.W., The search for luminescent organometallics with functional properties, the 13th National Symposium on Organometallic Chemistry, Beijing (Plenary lecture). 2004.

Yam V.W.W., The symposium entitled “Frontiers of Inorganic Photochemistry and Spectroscopy” at the 229th National Meeting of the American Chemical Society, San Diego, USA (Invited Lecture). 2005.

Yam V.W.W., The symposium entitled “Organic and Nanocomposite Optical Materials” at the 2004 Materials Research Society (MRS) Fall Meeting, Boston, USA (Supported by the Window on Science (WOS) program) (Invited Lecture). 2004.

Yam V.W.W., Wong M.C., Hung L.L. and Zhu N., Unprecedented luminescent gold(III) alkynyl complexes - synthesis, structural characterization and luminescent properties, Angewandte Chemie International Edition. 2005, 44: 3107-3110.

Yam V.W.W., Volume Editor (2005-06), Structure and Bonding. Springer, 2005.

Yip S.K., Cheng C.C., Yuan L., Zhu N. and Yam V.W.W., Supramolecular assembly of luminescent gold(I) alkynylcalix[4]crown-6 complexes with planar h² , h² - coordinated gold(I) centers, Angewandte Chemie International Edition. 2004, 43: 4954-4957.

Yip S.K., Cheung K.L., Yuan L., Cheung K.K., Zhu N. and Yam V.W.W., Synthesis, luminescence and ion-binding properties of gold(I) alkynylcalix[4]crown complexes, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Mr. Sung Kong Yip). 2004, P-79.

Yu C., Wong M.C., Chan H.Y. and Yam V.W.W., Polymer-induced self-assembly of alkynylplatinum(II) terpyridyl complexes via metal...metal/p...pinteractions, Angewandte Chemie International Edition. 2005, 44: 791-794.

Yu D. and Yam V.W.W., Controlled synthesis of monodisperse silver nanocubes in water, Journal of the American Chemical Society. 2004, 126(41): 13200-13201.

Yu D. and Yam V.W.W., Hydrothermal-induced assembly of colloidal silver spheres into various nanoparticles on the basis of HTAB-modified silver mirror reaction, Journal of Physical Chemistry B. 2005, 109: 5497-5503.

Researcher : Yan SC

List of Research Outputs

Yan S.C., Bioinorganic chemistry of antimony: interaction of antimonial with biomolecules(PhD). 2005.

Yan S.C., Jin L. and Sun H., ⁵¹ Sb-antimony in medicine, Metallotherapeutic Drugs and Metal-Based Diagnostic Agents: The Use of Metals in Medicine. John Wiley & Sons, Ltd, 2005, 441-461.

Researcher : Yang D

Project Title:	Aminoxy acids as foldamers: design, synthesis, and applications
Investigator(s):	Yang D
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2001

Abstract:

To develop chemical methods to provide a broad structural variety of aminoxy acids for the construction of combinatorial libraries; to explore the novel secondary structures of peptide containing [alpha]-aminoxy acids; to investigate the potential of [beta]-aminoxy acids as new foldamers.

Project Title:	HKU-Fudan Joint Laboratory on molecular design and synthesis - peptidominetics for drug discovery
Investigator(s):	Yang D, Chen G
Department:	Chemistry
Source(s) of Funding:	Vice-Chancellor's Office - General Award
Start Date:	03/2002

Abstract:

To develope chemical methods to provide a broad structural variety of aminoxy acids for the construction of combinatorial libraries; to explore the novel secondary structures of peptides containing [alpha]- and [beta]-aminoxy acids; to investigate the potential aminoxy acids in drug design.

Project Title:	Catalytic enantioselective atom transfer radical cyclization method for synthesis of biologically active natural products
Investigator(s):	Yang D
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2002

Abstract:

In a previous study, the research team has observed the highly enantioselective atom transfer radical cyclization reactions catalyzed by chiral Lewis acids. The objective of this project is to further explore the scope of chiral Lewis acid-catalyzed atom transfer radical cyclization method in asymmetric C-C bond formation and apply this method to the enantioslective total syntheses of biologically active natural products such as nitramine and candelalides A-C.

Project Title:	Aminoxy peptides as synthetic chloride channels
Investigator(s):	Yang D
Department:	Chemistry
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	09/2003

Abstract:

To design and synthesis of cyclic [alpha]-aminoxy peptides as models of chloride channels; to design and synthesis of linear [alpha]-aminoxy peptides as models of chloride channels; to characterize of synthetic chloride channels.

Project Title:	Aminoxy peptides as synthetic chloride channels
Investigator(s):	Yang D
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2003

Abstract:

Project Title:	Developing novel thiourea ligands for palladium-catalyzed cross coupling reactions
Investigator(s):	Yang D
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004
Completion Date:	01/2005

Abstract:

To develop new thiourea ligands for palladiumcatalyzed cross coupling reactions. This program will lead to discovery of new family of ligands with ready availability and sstability, which should significantly accelerate the development of fine chemical industry as well as pharmaceutical industries.

Project Title:	Design and synthesis of methionine aminopeptidase-2 inhibitors as anti-angiogenic agents
Investigator(s):	Yang D, Chen G
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	01/2005

Abstract:

To develop an expedient route to construct the common core structure of fumagillin and ovalicin; to design, synthesis and biological evaluations fumagillin analogs as irreversible inhibitors of MetAP-2; to design, synthesis and biological evaluations fumagillin analogs as reversible inhibitors of MetAP-2.

Project Title:	Ammonium salts as organocatalysts for asymmetric synthesis
Investigator(s):	Yang D
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2005

Abstract:

refer hard copy proposal

Project Title:	Design and synthesis of methionine aminopeptidase-2 inhibitors as anti-angiogenic agents
Investigator(s):	Yang D
Department:	Chemistry
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

List of Research Outputs

Chen F., Zhu N. and Yang D., g⁴ - Aminoxy peptides as new peptidomimetic foldamers, Journal of the American Chemical Society. 2004, 126: 15980-15981.

Chen F., Song K. and Yang D., g⁴-Aminoxy peptides as new peptidomimetic foldamers, The 12^th Symposium on Chemistry Postgraduate Research in Hong Kong,The City University of Hong Kong, April 23,2005.

Chen F. and Yang D., g⁴-Aminoxy peptides as new peptidomimetic foldamers, The 8^th International Symposium for Chinese Organic Chemists and the 5^th International Symposium for Chinese Inorganic Chemists,The Chinese University of Hong Kong Hong Kong, December 19-22,2004.

Chen H. and Yang D., AgBF₄ mediated cyclization of 1,6-enynes, The 12^th Symposium on Chemistry Postrgaduate Research in Hong Kong, The City University of Hong Kong, April 23,2005.

Gao Q., Zheng B., Li J. and Yang D., Ni(II)-catalyzed conia-ene reaction of 1,3-dicarbonyl compounds with alkynes, Organic Letters. 2005, 7(11): 2185-2188.

Hao Y., Zhang D., Zhu N. and Yang D., Conformational studies of b^2,3-cyclic aminoxy peptides, The 12^th Symposium on Chemistry Postgraduate Research in Hong Kong, The City University of Hong Kong, April 23,2005.

Ho C.Y., Chen Y., Wong M.K. and Yang D., Fluorinated chiral secondary amines as catalysts for epoxidation of olefins with oxone, The Journal of Organic Chemistry. 2005, 70: 898-906.

Law K.L. and Yang D., Photo-induced phenylseleno group transfer radical cyclization reactions for the formation of spirolactams, The 12^th Symposium on Chemistry Postgraduate Research in Hong Kong, The City University of Hong Kong, April 23,2005.

Law K.L. and Yang D., Photo-induced phenylseleno group transfer radical cyclization reactions for the formation of spirolactams, The 8^th International Symposium for Chinese Organic Chemists and the 5^th International Symposium for Chinese Organic Chemists,The Chinese University of Hong Kong, Hong Kong,December 19-22,2004.

Lee O.Y. and Yang D., Synthesis of heterocycles via phenylseleno group transfer radical cyclization reactions, The 12^th Symposium on Chemistry Postgraduate Research in Hong Kong, April 23,2005.

Lee O.Y. and Yang D., Synthesis of heterocycles via phenylseleno group transfer radical cyclization reactions, The 8^th International Symposium for Chinese Organic Chemists and the 5^th International Symposium for Chinese Inorganic Chemists, The Chinese University of Hong Kong, Hong Kong, December 19-22,2004 . 2004.

Li C. and Yang D., Total synthesis of 5-demethoxyfumagillol, The 12^th Symposium on Chemistry Postgraduate Research in Hong Kong, The City University of Hong Kong, April 23,2005.

Li J.H., Zhu Q.M., Liang Y. and Yang D., Efficient and reusable PdCl₂(MeCN)₂/CuCl₂/PEG-400 system for cyclization of alkenyl !b-Keto esters and amides, Journal of Organic Chemistry. 2005, 70: 5347-5349.

Li X., Fan Y.F. and Yang D., Enantioselective carboxylate recognition: A novel receptor derived from a-Aminoxy acids functions as a chiral shift reagent, The 12^th Symposium on Chemistry Postgraduate Research in Hong Kong, The City University of Hong Kong - Oral Presentation, April 23, 2005.

Yang D., Li X., Sha Y. and Wu Y.D., A cyclic hexapeptide comprising alternating a-aminioxy and a-amino acids is a selective chloride ion receptor, Chemistry - A European Journal. 2005, 11: 3005-3009.

Yang D., Catalytic asymmetric cyclization reactions for natural product synthesis, The 39^th National Organic Chemistry Symposium, Jun 12-16, 2005, Utah, USA. 2005.

Yang D., Catalytic asymmetric radical cyclization reactions for natural product synthesis, The 3^rd National Organic Chemistry Symposium 2004,Aug 11-14,2004, Lanzhou, China. 2004.

Yang D., Catalytic asymmetric radical cyclization reactions for natural product synthesis, The IUPAC 15^th International Conference on Organic Synthesis, Aug 1-6,2004, Nagoya, Japan. 2004.

Yang D., Li X., Fan Y.F. and Zhang D.W., Enantioselective recognition of carboxylates: A receptor derived from a-aminoxy acids functions as a chiral shift reagent for carboxylic acids, Journal of the American Chemical Society. 2005, 127: 7996-7997.

Yang D., Gao Q., Zheng B. and Zhu N., Et²ALCL-Promoted asymmetric phenylseleno group transfer radical cyclization reactions of unsaturated b-hydroxy esters, Journal of Organic Chemistry. 2004, 69(25): 8821-8828.

Yang D., Explorations on radical and non-radical cyclization reactions, Gordon Research Conference on Heterocyclic Compounds, Jul 4-9,2004,Rhode Island, USA. 2004.

Yang D., Explorations on radical and non-radical cyclization reactions, The 2^nd Fukuoka Symposium on "New-Generation Catalysts for New-Generation Synthesis", Jan18 , 2005, Fukuoka, Japan. 2005.

Yang D., Invited lecture at California Institute of Technology (20 Oct,2004;USA). 2004.

Yang D., Invited lecture at Fudan University (3 Jun 2005;Shanghai, China). 2005.

Yang D., Invited lecture at Shanghai Institute of Materia Medica (7 Jun 2005;Shanghai, China). 2005.

Yang D., Invited lecture at Shanghai Institute of Organic Chemistry (6 Jun,2005;Shanghai, China). 2005.

Yang D., Invited lecture, The 2^nd Fukuoka Symposium on "New-Generation Catalysts for New-Generation Synthesis"(Fukuoka, Japan, 18 Jan,2005). 2005.

Yang D., Invited lecture, The Gordon Research Conference on Heterocyclic Compounds (Rhode Island, USA, 4-9 Jul,2004). 2004.

Yang D., Invited lecture, The IUPAC 15^th International Conference on Organic Synthesis (Nagoya, Japan, 1-6 Aug, 2004). 2004.

Yang D., Invited lecture, The International Conference on Rare Earths 2004 (Nara, Japan, 7-12 Nov,2004). 2004.

Yang D., Ketone-catalyzed asymmetric epoxidation reactions (invited article to a special issue entitled "Enantioselective Organocatalysis") , Accounts of chemical research. 2004, 37: 497-505.

Yang D., Lanthanide triflates-catalyzed asymmetric cyclization reactions, The International Conference on Rare Earths 2004,Nov 7-12,2004, Nara, Japan. 2004.

Yang D., Member of Editorial Advisory Board for Beilstein Journal of Organic Chemistry, 2005.

Yang D., Plenary lecture, The 39^th National Organic Chemistry Symposium (Utah, USA, 12-16 Jun, 2005). 2005.

Yang D., Plenary lecture, The 3^rd National Organic Chemistry Symposium 2004 (Lanzhou, China, 11-14 Aug,2004). 2004.

Yang D., Zhang Y., Li B. and Zhang D., Synthesis of chiral b³-Aminoxy peptides, Journal of Organic Chemistry. 2004, 69: 7577-7581.

Yang D., Ten outstanding young persons award, Junior Chamber International Hong Kong, 9 October 2004. 2004.

Yang D., Yip K.T.P., Li J. and Lee O.Y., Ytterbium triflate and palladium(II)-catalyzed oxidative cyclization of alkenyl b-keto amdes with molecular oxygen. An approach to heterocycles, The IUPAC 15^th International Conference on Organic Synthesis,Aug 1-6,2004,Nagoya, Japan. 2004.

Yang D., Zhang D.W., Hao Y., Wu Y.D., Luo S.W. and Zhu N., b²,³ - Cyclic aminoxy acids:rigid and ring-size-independent building blocks of foldamers, Angewandte Chemie International Edition. 2004, 43: 6719-6722.

Researcher : Yang N

List of Research Outputs

Sun H. and Yang N., Bismuth complex as an enzyme inhibiotr: From antibacterium to antivirus, Abstract of the Second Asian Biological Inorganic Chemistry Conference (AsBIC-II), Goa, Indai, Dec 5-10, 2004.

Researcher : Yang P

List of Research Outputs

Yang P., Sun X., Chiu J., Sun H. and He Q., Transferrin-mediated gold nanoparticle cellular uptake, Bioconjugate Chemistry. 2005, 16: 494-496.

Researcher : Yang Y

List of Research Outputs

Guan X., Tse M.K., Yang Y., Sze K.H., Cheung K.K. and Wong K.B., Structure and dynamics of a thermophilic acylphosphatase from Pyrococcus horikoshii by NMR spectroscopy - structural basis of thermostability and enzymatic activities, Twelfth Symposium on Chemistry Postgraduate Research in Hong Kong, Hong Kong, The City University of Hong Kong, 23 Apr. 2005. 43.

Sze K.H., Yang Y., Guan X., Tse M.K. and Barsukov I., Combined computational and experimental developments for automated determination of protein structures by NMR, XXI International Conference on Magnetic Resonance in Biologicall Systems, Hyderabad, India, 16-21 Jan, 2005. 94.

Sze K.H., Lin D., Liu X., Yang Y., Guan X. and Zhu G., Mapping protein-protein interactions by solvent exposed amides experiment, XXI International Conference on Magnetic Resonance in Biologicall Systems, Hyderabad, India, 16-21 Jan, 2005. 95.

Sze K.H., Yang Y., Guan X., Tse M.K., Cheung K.K. and Wong K.B., Structure and dynamics of a thermophilic acylphosphatase from Pyrococcus horikoshii by NMR spectroscopy - structural basis of thermostability and enzymatic activities, XXI International Conference on Magnetic Resonance in Biologicall Systems, Hyderabad, India, 16-21 Jan, 2005. 155.

Yang Y., Huang Z.Q., Chen X.M., Wong W.T. and Ng S.W., Diiodobis (2-hydroxymethyl-1-methyl-1-imidazole-N³)cadmium(II), Applied Organometallic Chemistry. 2005, 19: 354-355.

Yang Y., Guan X., Tse M.K., Sze K.H. and Haynes R.K., Eluciation of solution conformations of loloatins by NMR spectroscopy, The 12^th Symposium on Chemistry Postgraduate Research in Hong Kong, The City University of Hong Kong, Hong Kong, Apr 23,2005. 45.

Yang Y., Sze-To L., Ouyang G.F., Huang Z.Q., Wong W.T. and Ng S.W., m₂Diiodotetrakis(2-hydroxymethyl-1-methyl-1-imidazole-N³)dicadmium(II) bis[triiodo(2-hydroxymethyl-1-methyl-1-imidazole-N³)cadmate(II)] dihydrate, Applied Organometallic Chemistry. 2005, 19: 352-353.

Researcher : Yang Y

List of Research Outputs

Yang Y., Huang Z.Q., Chen X.M., Wong W.T. and Ng S.W., Diiodobis (2-hydroxymethyl-1-methyl-1-imidazole-N³)cadmium(II), Applied Organometallic Chemistry. 2005, 19: 354-355.

Researcher : Yang Z

List of Research Outputs

Yang Z., Wong L.M.E., Shum Y.T., Che C.M. and Hui Y., Fluorophore-appended steroidal saponin (Dioscin and Polyphyllin D) derivatives, Organic Letters. 2005, 7: 669-672.

Researcher : Ye J

List of Research Outputs

Tam W.S., Ye J. and Cheung A.S.C., Near-infrared laser spectroscopy of NiI, Journal of Chemical Physics. 2004, 121(19): 9430-9435.

Ye J., Leung W.H. and Cheung A.S.C., Laser spectroscopy of nickel monobromide, 60th Ohio State University International Symposium on Molecular Spectroscopy, U.S.A., June 20-24. 2005, FB04.

Researcher : Yip KL

List of Research Outputs

Yip K.L., Ruthenium and osmium-nitrogen multiple bonded complexes with chelating nitrogen and / or oxygen atom donor ligands: synthesis, structures and reactivity studies(PhD). 2005.

Researcher : Yip KTP

List of Research Outputs

Yang D., Yip K.T.P., Li J. and Lee O.Y., Ytterbium triflate and palladium(II)-catalyzed oxidative cyclization of alkenyl b-keto amdes with molecular oxygen. An approach to heterocycles, The IUPAC 15^th International Conference on Organic Synthesis,Aug 1-6,2004,Nagoya, Japan. 2004.

Researcher : Yip SK

List of Research Outputs

Cheung K.L., Yip S.K. and Yam V.W.W., Synthesis, characterization, electrochemistry and luminescence studies of heterometallic gold(I)-rhenium(I) alkynyl complexes, Journal of Organometallic Chemistry. 2004, 689(24): 4451-4462.

Yam V.W.W., Cheung K.L., Yip S.K. and Zhu N., Synthesis, characterization, electrochemistry and luminescence studies of 9-anthrylgold(I) complexes, Photochemical and Photobiological Sciences. 2005, 4: 149-153.

Yip S.K., Cheng C.C., Yuan L., Zhu N. and Yam V.W.W., Supramolecular assembly of luminescent gold(I) alkynylcalix[4]crown-6 complexes with planar h² , h² - coordinated gold(I) centers, Angewandte Chemie International Edition. 2004, 43: 4954-4957.

Yip S.K., Cheung K.L., Yuan L., Cheung K.K., Zhu N. and Yam V.W.W., Synthesis, luminescence and ion-binding properties of gold(I) alkynylcalix[4]crown complexes, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Mr. Sung Kong Yip). 2004, P-79.

Researcher : Yip SK

List of Research Outputs

Researcher : Yip WP

List of Research Outputs

Cheung W.H., Yip W.P., Yu W.Y. and Che C.M., Oxidation of Ansioles to p-Benzoquinones Monoketals catalyzed by a Ruthenium complex of 1,4,7-Trimethyl-1, 4, 7-TriazacyclononaNe with tert-Buty1 Hydroperoxide, Canadian Jouranl of Chemistry. 2005, 83(6-7): 521-536.

Researcher : You T

List of Research Outputs

Fung Y.S., Gong F. and You T., Sensing beverage tastes from organic acids separated by capillary electrophoresis and assessed by pattern recognition, Abstract of the 10^th International Meeting on Chemical Sensors (IMCS-10), Tsukuba, Japan, July 11-14, 2004, 2P050. 2004.

Fung Y.S., Gong F. and You T., Sensing beverage tastes from organic acids separated by capillary electrophoresis and assessed by pattern recognition, Chemical Sensors. 2004, 20: 480-481.

You T., Sun H. and Fung Y.S., Electrochemical detector for indirect detection of amino acids after CE separation, Abstract 7^th Asian Conf. on Anal. Sci., Hong Kong SAR, China, July 28-31, 2004, F079-P. 2004, p491.

Zhao L., You T. and Fung Y.S., Characterization of nanoparticles by gas-phase electrophoretic mobility molecular analyser (GEMMA) :Electrospray diagnostics, Abstract of 7^th Asian Conf. on anal. Sci., Hong Kong, July 28-31, 2004, F084-P. 2004, p496.

Researcher : Yu C

List of Research Outputs

Wong M.C., Chan H.Y., Yu C. and Yam V.W.W., Photophysical and aggregation studies of luminescent organoplatinum(II) terpyridyl complexes, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Dr Keith Man Chun Wong). 2004, 0-8.

Yu C., Wong M.C., Chan H.Y. and Yam V.W.W., Polymer-induced self-assembly of alkynylplatinum(II) terpyridyl complexes via metal...metal/p...pinteractions, Angewandte Chemie International Edition. 2005, 44: 791-794.

Researcher : Yu D

List of Research Outputs

Yu D. and Yam V.W.W., Controlled synthesis of monodisperse silver nanocubes in water, Journal of the American Chemical Society. 2004, 126(41): 13200-13201.

Yu D. and Yam V.W.W., Hydrothermal-induced assembly of colloidal silver spheres into various nanoparticles on the basis of HTAB-modified silver mirror reaction, Journal of Physical Chemistry B. 2005, 109: 5497-5503.

Researcher : Yu S

List of Research Outputs

Vellaisamy A.L.R., Zhi Y.G., Xu Z., Yu S., Chan P.W.H. and Che C.M., Functionalized arylacetylene oligomers for organic thin-film transistors (OTFTs), Advanced Materials. 2005, 17: 1258-1261.

Researcher : Yu SC

List of Research Outputs

Kwok C.C., Yu S.C., Sham I.H.T. and Che C.M., Self-aggregated phosphorescent platinum(II) polymeric material from modified poly(4-vinylpyridine), Chemical Communications. 2004, 2512-2513.

Kwok C.C., Yu S.C., Sham I.H.T. and Che C.M., Self-assembled zinc(II) Schiff base polymers for applications in polymer light-emitting devices, Chemical Communications. 2004, 2758-2759.

Researcher : Yu WY

Project Title:	Ruthenium-carbenoids for carbon-carbon bond formations: asymmetric catalysis, catalyst design and synthetic applications
Investigator(s):	Yu WY, Chan PWH
Department:	Chemistry
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	09/2003

Abstract:

Refer to hard copy

Project Title:	Ruthenium-carbenoids for carbon-carbon bond formations: asymmetric catalysis, catalyst design and synthetic applications
Investigator(s):	Yu WY, Chan PWH
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2003

Abstract:

Refer to hard copy

Project Title:	Transition Metal Catalyzed Organic Oxidations by Hydrogen Peroxide via a-Hydroxy Hydroperoxides as Oxygen Atom Transfer Mediator
Investigator(s):	Yu WY
Department:	Chemistry
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2004

Abstract:

Refer to hard copy

List of Research Outputs

Cheung W.H., Yip W.P., Yu W.Y. and Che C.M., Oxidation of Ansioles to p-Benzoquinones Monoketals catalyzed by a Ruthenium complex of 1,4,7-Trimethyl-1, 4, 7-TriazacyclononaNe with tert-Buty1 Hydroperoxide, Canadian Jouranl of Chemistry. 2005, 83(6-7): 521-536.

Choi K.W.M., Yu W.Y. and Che C.M., Ruthenium-catalyzed stereoselective intramolecular carbenoid C-H insertion for !b- and !g-lactam formations by decomposition of a-diazoacetamides, Organic Letters. 2005, 7: 1081-1084.

He L., Chan P.W.H., Tsui W.M., Yu W.Y. and Che C.M., Ruthenium(II) porphyrin-catalyzed amidation of aromatic heterocycles , Organic Letters. 2004, 6: 2405-2408.

Ren Y., Li W., Liu Q., Yu W.Y., Sun R.W.Y., Che C.M. and Tam P.K.H., Gold (III) porphyrines: a novel chemotherapeutic agent for human neuroblastoma, 51st Annual International Congress of British Association of Paediatric Surgeons, Oxford, U.K. 27-30 July. 2004.

Sun R.W.Y., Yu W.Y., Sun H. and Che C.M., In vitro inhibition of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase by gold(III) porphyrins, ChemBioChem. 2004, 5(9): 1293-1298.

Zhou C., Yu W.Y., Chan P.W.H. and Che C.M., Ruthenium porphyrin catalyzed tandem sulfonium/ammonium ylide formation and [2,3] - sigmatropic rearrangement. A concise synthesis of (±)-platynecine, Journal of Organic Chemistry. 2004, 69(21): 7072-7082.

Researcher : Yuan L

List of Research Outputs

Yip S.K., Cheng C.C., Yuan L., Zhu N. and Yam V.W.W., Supramolecular assembly of luminescent gold(I) alkynylcalix[4]crown-6 complexes with planar h² , h² - coordinated gold(I) centers, Angewandte Chemie International Edition. 2004, 43: 4954-4957.

Yip S.K., Cheung K.L., Yuan L., Cheung K.K., Zhu N. and Yam V.W.W., Synthesis, luminescence and ion-binding properties of gold(I) alkynylcalix[4]crown complexes, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Mr. Sung Kong Yip). 2004, P-79.

Researcher : Yuen WH

List of Research Outputs

Au W.Y., Cheung G.T.Y., Yuen W.H., Kumana C.R. and Kwong Y.L., Successful treatment of relapsed acute promyelocytic leukemia in a patient receiving continuous ambulatory peritoneal dialysis with oral arsenic trioxide, Archite Internal Medicine. 2005, 165: 1067-1068.

Chang R.C.C., Yu M.S., Leung S.K.Y., Lai S.W., Che C.M., Zee S.S.Y., So K.F. and Yuen W.H., Neuroprotective effects of anti-aging Chinese Medicine Lycium barbarum against b-amyloid peptide neurotoxicity. (Best Poster Prize in Poster Session 2), International Congress on Complementary and Alternative Medicines (ICCAM) 2005, 26-28 February 2005, Singapore. 2005, 145.

Fang X., Chang R.C.C., Yuen W.H. and Zee S.S.Y., Immune modulatory effects of Prunella vulgaris L., International Journal of Molecular Medicine. 2005, 15: 491-496.

Pritchard R.G., Stoodley R.J. and Yuen W.H., Studies related to carba-pyranoses: synthesis of acetylated derivatives of 4-amino-2,4-dideoxy-3-O(b-D-glucopyranosyl)-b-L-(and b-D-) altrocarba-pyranose from a D-glucose template, Organic & Biomolecular Chemistry. 2005, 3(1): 162-171.

So K.F., Chan H.C., Chang R.C.C., Chan Y.M.S., Yuen W.H. and Zee S.S.Y., Neuroprotection and Chinese Herbal Extracts, International Symposium on Chemicals and Pharmaceutical, Guangzhou, China. 2004, 15.

Yu M.S., Lai S.W., Lin K.F., Fang J.N., Yuen W.H. and Chang R.C.C., Characterization of polysaccharides from the folowers of Nerium indicum and their neuroprotective effects, International Journal of Molecular Medicine. 2004, 14: 917-924.

Yu M.S., Leung K.Y., Lai S.W., Che C.M., Zee S.S.Y., So K.F., Yuen W.H. and Chang R.C.C., Neuroprotective effects of anti-aging oriental medicine Lycium barbarum against bamyloid peptide neurotoxicity, Experimental Gerontology. 2005, 40: 716-727.

Yu M.S., Lai S.W., So K.F., Yuen W.H. and Chang R.C.C., Protein kinases as technological platforms to screen neuroprotective agents from Chinese medicine, The Hong Kong Society of Neurosciences, the 24th Annual Scientific Meeting, 2005. 69 No.P-36.

Researcher : Yung KF

Project Title:	The chemistry of osmium nanoparticles
Investigator(s):	Yung KF, Wong WT
Department:	Chemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To establish new synthetic routes to osmium nanoparticles; to study the physical and chemical properties of osmium nanoparticles; to investigate the factor that control the size of osmium nanoparticles.

Researcher : Zhang D

List of Research Outputs

Hao Y., Zhang D., Zhu N. and Yang D., Conformational studies of b^2,3-cyclic aminoxy peptides, The 12^th Symposium on Chemistry Postgraduate Research in Hong Kong, The City University of Hong Kong, April 23,2005.

Yang D., Zhang Y., Li B. and Zhang D., Synthesis of chiral b³-Aminoxy peptides, Journal of Organic Chemistry. 2004, 69: 7577-7581.

Researcher : Zhang J

List of Research Outputs

Zhang J., Liang J., Sun X., Zhou H., Zhu N., Zhou Z.Y., Chan P.W.H. and Che C.M., Chiral osmium complexes with sterically bulky schiff-base lignads. Crystal structures of Os(IV) derivatives and the reactivity and catalytic cyclopropanation of alkenes with EDA, Inorganic Chemistry. 2005, 44: 3942-3954.

Zhang J. and Che C.M., Dichlororuthenium(IV) complex of meso-tetrakis(2,6-dichlorophenyl) porphyrin: Active and robust catalyst for highly selective oxidation of arenes, unsaturated steroids, and electron-deficient alkenes by using 2,6-dichloropyridine N-oxide, Chemistry - A European Journal. 2005, 11: 3899-3914.

Zhang J., Syntheses and spectroscopic studies of luminescent surfactant rhenium(I) and ruthenium(II) diimine complexes -potential applications as functional materials for second-harmonic generation and mesoporous silicate formation(PhD). 2005.

Researcher : Zhang J

List of Research Outputs

Researcher : Zhang L

List of Research Outputs

Jin L., Szeto K.Y., Zhang L., Du W. and Sun H., Inactivation of alcohol dehydrogenase by bismuth complex, Journal of Inorganic Biochemistry. 2004, 98: 1331-1337.

Researcher : Zhang X

List of Research Outputs

Li S., Zhang X., Ko Y.Y. and Chiu P., Application of the rhodium-catalyzed carbene cyclization cycloaddition cascade to the synthesis of natural products, International Symposium on Catalysis and Fine Chemicals 2004(C&FC 2004) - Poster Presentation, Hong Kong Polytechnic University, Dec 12 -15. 2004, P-122.

Zhang X., Tsang K.Y. and Chan G.K.Y., Electrocatalytic properties of supported platinum-cobalt nanoparticles with uniform and controlled composition, Journal of Electroanalytical Chemistry. 2004, 573: 1-9.

Researcher : Zhang Y

List of Research Outputs

Fung Y.S., Sun H., Zhang Y., Yao S. and Yam W.C., PCR/DNA piezoelectric quartz crystal biosensor for bacteria sensing, Abstract of 2^nd France China Workshop on Surface Molecules of Biological Interest: Biosensor Applications, October 13-16, 2004, Céret, France, p 36. 2004, 36.

Fung Y.S., Sun H., Zhang Y., Yao S.Z. and Yam W.C., PCR/DNA piezoelectric quartz crystal biosensor for bacteria sensing, Invited lecture at Plenary Session of 2^nd France China Workshop on Surface Molecules of Biological Interest: Biosensor Application, Céret, France, October 13-16. 2004.

Fung Y.S., Yam W.C., Zhang Y. and Sun H., PCR/DNA quartz crystal microbalance biosensor for detecting bacteria in environmental water samples, Abstract of The 56^th Annual Pittsburgh Conference and Exposition on Analytical Chemistry and Applied Spectroscopy (PITTCONF 2005), Orlando, Florida, USA, February 27-March 4,2005, 2250-5. 2005, 2250-2255.

Sun H., Si S., Zhang Y., Zhu D. and Fung Y.S., Piezoelectric quartz crystal (PQC) with photochemically deposited nano-sized Ag particles for determinig cyanide at trace levels in water, Chemical Sensors. 2004, 20: 500-502.

Sun H., Si S., Zhang Y., Zhu D. and Fung Y.S., Piezoelectric quartz crystal (PQC) with photochemically deposited nano-sized Ag particles for determining cyanide at trace levels in water, Abstract of the 10^th International Meeting on Chemical Sensors (IMCS-10), Tsukuba, Japan, July 11-14, 2004, 2P061. 2004.

Yang D., Zhang Y., Li B. and Zhang D., Synthesis of chiral b³-Aminoxy peptides, Journal of Organic Chemistry. 2004, 69: 7577-7581.

Zhang Y., Sun H., Fung Y.S. and Yao S., Quantitative determination of bacteria by DNA piezoelectric biosensor, Abstract of 7^th Asian conf. on anal. Sci., Hong Kong SAR, China, July 28-31, 2004, E063-P. 2004, p296.

Zhang Y., Fung Y.S. and Yao S., Study of protein adsorption on polymer coatings surface by quartz crystal microbalance and electrochemical impedance methods, Abstract of the 10^th International Meeting on Chemical Sensors (IMCS-10), Tsukuba, Japan, July 11-14, 3P064. 2004.

Zhang Y., Fung Y.S. and Yao S., Study of protein adsorption on polymer coatings surface by quartz crystal microbalance and electrochemical impedance methods, Chemical Sensors. 2004, 20: 760-761.

Zhang Y., b-Aminoxy peptides as new foldamers: synthesis and conformational studies(PhD). 2004.

Researcher : Zhang Y

List of Research Outputs

Yang D., Zhang Y., Li B. and Zhang D., Synthesis of chiral b³-Aminoxy peptides, Journal of Organic Chemistry. 2004, 69: 7577-7581.

Zhang Y., b-Aminoxy peptides as new foldamers: synthesis and conformational studies(PhD). 2004.

Researcher : Zhang Y

List of Research Outputs

Yang D., Zhang Y., Li B. and Zhang D., Synthesis of chiral b³-Aminoxy peptides, Journal of Organic Chemistry. 2004, 69: 7577-7581.

Zhang Y., b-Aminoxy peptides as new foldamers: synthesis and conformational studies(PhD). 2004.

Researcher : Zhao C

List of Research Outputs

Guan X., Lin X., Kwok W.M., Du Y., Li Y., Zhao C., Wang D. and Phillips D.L., Ultraviolet photolysis of CH₂I₂ in ,methanol: O-H insertion and HI elimination reactions to form a dimethoxymethane product, Journal of Physical Chemistry A. 2005, 109(6): 1247-1256.

Lin X., Zhao C. and Phillips D.L., Ab initio investigation of the O-Y (Y=CH₃, H) insertion/HI elimination reactions of CH₂I-I with CH₃OH and H₂O: comparison of methanol and water catalyzed reactions, Chemical Physics Letters. 2004, 397: 488-494.

Lin X., Zhao C. and Phillips D.L., An ab inition study of the reactions of CH₂X-X (X=C1,Br, I) isopolyhalomethanes with nCH₃OH, Molecular Simulation. 2005, 31(6-7): 483-488.

Lin X., Guan X., Kwok W.M., Zhao C., Du Y., Li Y. and Phillips D.L., Water-catalyzed O-H insertion/HI elimination reactions of isodihalomethanes (CH₂X-I, where x=CI,Br, I) with water and the dehalogenation of dihalomethanes in water-solvated environments, Journal of Physical Chemistry A. 2005, 109(6): 981-998.

Phillips D.L., Kwok W.M., Zhao C., Guan X., Du Y., Li Y. and Wang D., Water assisted dehalogenation reactions of selected isopolyhalomethanes, halomethanols and haloformaldehydes, Abstract of 229^th ACS National Meeting, San Diego, California, U.S.A., March 13 - March 17, 2005. Phys. 2005.

Wang D., Zhao C. and Phillips D.L., Samarium(III) carbenoid as a competing reactive species in samarium-promoted cyclopropanation reactions, Journal of Organic Chemistry. 2004, 69: 5512-5515.

Zhao C., Lin X., Kwok W.M., Guan X., Du Y., Wang D., Hung K.F. and Phillips D.L., Water-catalyzed dehalogenation reactions of the isomer of CBr₄ and its reaction products and a comparison to analogous reactions of the isomers of d- and trihalomethanes, Chemistry - A European Journal. 2005, 11(4): 1093-1108.

Researcher : Zhao L

List of Research Outputs

Zhao L., You T. and Fung Y.S., Characterization of nanoparticles by gas-phase electrophoretic mobility molecular analyser (GEMMA) :Electrospray diagnostics, Abstract of 7^th Asian Conf. on anal. Sci., Hong Kong, July 28-31, 2004, F084-P. 2004, p496.

Researcher : Zhao Y

Project Title:	Computer simulation of carbon nanotube bearings and nanoscopic equipartition processes
Investigator(s):	Zhao Y
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2005

Abstract:

refer to hard copy proposal

List of Research Outputs

Zhao Y., Zanardi P. and Chen G., Quantum entanglement and the self-trapping transition in polaronic systems, Physical Review B. 2004, 70: 195113-1 - 195113-5.

Researcher : Zheng B

List of Research Outputs

Gao Q., Zheng B., Li J. and Yang D., Ni(II)-catalyzed conia-ene reaction of 1,3-dicarbonyl compounds with alkynes, Organic Letters. 2005, 7(11): 2185-2188.

Yang D., Gao Q., Zheng B. and Zhu N., Et²ALCL-Promoted asymmetric phenylseleno group transfer radical cyclization reactions of unsaturated b-hydroxy esters, Journal of Organic Chemistry. 2004, 69(25): 8821-8828.

Researcher : Zheng H

List of Research Outputs

Zheng H. and Zu Y., Emission of Tris(2,2'-bipyridine)ruthenium(II) by coreactant electrogenerated chemiluminescence: from O₂-insensitive to highly O₂-Sensitive , Journal of Physical Chemistry B. American Chemical Society, 2005, 109: 12049-12053.

Zu Y. and Zheng H., Oxygen effect on coreactant electrogenerated chemiluminescence , 5th Asian Conference on Electrochemistry ( ACEC 2005). 2005.

Researcher : Zhi YG

List of Research Outputs

Vellaisamy A.L.R., Zhi Y.G., Xu Z., Yu S., Chan P.W.H. and Che C.M., Functionalized arylacetylene oligomers for organic thin-film transistors (OTFTs), Advanced Materials. 2005, 17: 1258-1261.

Researcher : Zhou C

List of Research Outputs

Zhou C., Yu W.Y., Chan P.W.H. and Che C.M., Ruthenium porphyrin catalyzed tandem sulfonium/ammonium ylide formation and [2,3] - sigmatropic rearrangement. A concise synthesis of (±)-platynecine, Journal of Organic Chemistry. 2004, 69(21): 7072-7082.

Researcher : Zhou H

List of Research Outputs

Zhang J., Liang J., Sun X., Zhou H., Zhu N., Zhou Z.Y., Chan P.W.H. and Che C.M., Chiral osmium complexes with sterically bulky schiff-base lignads. Crystal structures of Os(IV) derivatives and the reactivity and catalytic cyclopropanation of alkenes with EDA, Inorganic Chemistry. 2005, 44: 3942-3954.

Researcher : Zhu D

List of Research Outputs

Fung Y.S., Si S., Zhu D. and Sun H., Nanoporous TiO₂ film as coating for piezoelectric crystal sensor in the detection of organic vapours in air , Abstract of the 10^th International Meeting on Chemical Sensors (IMCS-10), Tsukuba, Japan, July 11-14, 2004, 3P029. 2004.

Fung Y.S., Si S., Zhu D. and Sun H., Nanoporous TiO₂ film as coating for piezoelectric crystal sensor in the detection of organic vapours in air , Chemical Sensors. 2004, 20: 698-699.

Qin J.H., Leung F.C.C., Fung Y.S., Zhu D. and Lin B.C., Rapid authentication of ginseng species using microchip electrophoresis with laser-induced fluorescence detection, Analytical and Bioanalytical Chemistry . 2005, 381: 812-819.

Sun H., Si S., Zhang Y., Zhu D. and Fung Y.S., Piezoelectric quartz crystal (PQC) with photochemically deposited nano-sized Ag particles for determinig cyanide at trace levels in water, Chemical Sensors. 2004, 20: 500-502.

Sun H., Si S., Zhang Y., Zhu D. and Fung Y.S., Piezoelectric quartz crystal (PQC) with photochemically deposited nano-sized Ag particles for determining cyanide at trace levels in water, Abstract of the 10^th International Meeting on Chemical Sensors (IMCS-10), Tsukuba, Japan, July 11-14, 2004, 2P061. 2004.

Zhu D., Sun H. and Fung Y.S., Electrochemical performance of nano-TiO2 modified LiCoO2 cathode material in room temperature molten salts for lithium battery application, Invited lecture at Electrodeposition Session of 1^st Asian and 9^th China-Japan Bilateral Conference on Molten Salt Chemistry and Technology, Wuhu, China, May 23-27. 2005.

Zhu D., Sun H. and Fung Y.S., Electrochemical performance of nano-TiO2 modified LiCoO2 cathode material in room temperature molten salts for lithium battery application, Proceedings 1^st Asian and 9^th China-Japan Bilateral Conference on Molten Salt Chemistry and Technology, Wuhu, China, May 23-27, 2005, 54-57. 2005, 54-57.

Researcher : Zhu D

List of Research Outputs

Fung Y.S., Si S., Zhu D. and Sun H., Nanoporous TiO₂ film as coating for piezoelectric crystal sensor in the detection of organic vapours in air , Chemical Sensors. 2004, 20: 698-699.

Zhu D., Sun H. and Fung Y.S., Electrochemical performance of nano-TiO2 modified LiCoO2 cathode material in room temperature molten salts for lithium battery application, Proceedings 1^st Asian and 9^th China-Japan Bilateral Conference on Molten Salt Chemistry and Technology, Wuhu, China, May 23-27, 2005, 54-57. 2005, 54-57.

Researcher : Zhu N

List of Research Outputs

Chen F., Zhu N. and Yang D., g⁴ - Aminoxy peptides as new peptidomimetic foldamers, Journal of the American Chemical Society. 2004, 126: 15980-15981.

Cheng C.C., Lo W.Y., Zhu N. and Yam V.W.W., Luminescent soluble polynuclear gold(I) chalcogenido aggreates-syntheses, characterization and photophysics, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Dr. Eddie Chung Chin Cheng). 2004, P-9.

Chong H.F., Lam C.F., Yam V.W.W., Zhu N., Cheung K.K., Fathallah S., Costuas K. and Halet J.F., Luminescent heterometallic branched alkynyl complexes of rhenium(I) - palladium(II): potential building blocks for heterometallic metallodendrimers, Organometallics. 2004, 23(21): 4924-4933.

Hao Y., Zhang D., Zhu N. and Yang D., Conformational studies of b^2,3-cyclic aminoxy peptides, The 12^th Symposium on Chemistry Postgraduate Research in Hong Kong, The City University of Hong Kong, April 23,2005.

Huang J.S., Leung K.Y., Zhou Z.Y., Zhu N. and Che C.M., Tuning the Reactivity of Dioxoruthenium(VI) Porphyrins toward anArylimine by Altering Porphyrin Substituents, Inorganic Chemistry. 2005, 44: 3780-3788.

Ko C.C., Wu L., Zhu N. and Yam V.W.W., Synthesis, photochromic and luminescence switching properties of photochromic rhenium(I) complexes, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Dr. Chi Chiu Ko). 2004, 0-17.

Kwok C.C., Ngai H.M.Y., Chan J.S.C., Sham I.H.T., Che C.M. and Zhu N., [(O^N^N)PtX] Complexes as a new class of light-emitting materials for electrophosphorescent devices, Inorganic Chemistry. 2005, 44: 4442-4444.

Lai S.W., Hou Y., Che C.M., Pang H.L., Wong K.Y., Chang C.K. and Zhu N., Electronic Spectroscopy, Photophysical Properties, and Emission Quenching Studies of an Oxidatively Robust Perfluorinated Platinum Porphyrin, XX IUPAC Symposium on Photochemistry, Granada, Spain, 17-22 July. 2004.

Lai S.W., Hou Y., Che C.M., Peng H.L., Wong K.Y., Chang C.K. and Zhu N., Electronic spectroscopy, photophysical properties, and emission quenching studies of an oxidatively robust perfluorinated platinum porphyrin, 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), The University of Hong Kong, Hong Kong, P. R. China, 4-9 July. 2004.

Lam C.F., Wong M.C., Zhu N., Yam V.W.W., Roué S., Lapinte C., Fathallah S., Costuas K., Kahlal S. and Halet J.F., Electro-swithchable photoluminescence of rhenium-iron mixed-metal alkynyl complexes, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Miss Sally Chan Fung Lam). 2004, P-31.

Li C.K., Lu X., Wong M.C., Chan C.L., Zhu N. and Yam V.W.W., Molecular design of luminescence ion probes for various cations based on weak gold(I)...gold(I) interactions in dinuclear gold(I) complexes, Inorganic Chemistry. 2004, 43(23): 7421-7430.

Li Y., Huang J.S., Xu G.B., Zhu N., Zhou Z.Y., Che C.M. and Wong K.Y., Spectral, structural, and electrochemical properties of ruthenium porphyrin diaryl and aryl(alkoxycarbonyl) carbene complexes: influence of carbene substituents, porphyrin substituents, and trans-axial ligands, Chemistry A European Journal. 2004, 10: 3486-3502.

Lin Y., Lai S.W., Che C.M., Fu W., Zhou Z.Y. and Zhu N., Structural variations and spectroscopic properties of luminescent mono-and multinuclear silver(I) and copper(I) complexes bearing phosphine and cyanide ligands, Inorganic Chemistry. 2005, 44: 1511-1524.

Lo K.W., Chan S.W., Chung C.K., Tsang W.H. and Zhu N., Synthesis, photophysical and electrochemical properties, and biological labelling studies of luminescent cyclometallated iridium(III) bipyridine-aldehyde complexes, Inorganica Chimica Acta. 2004, 357: 3109-3118.

Lo W.Y., Lam C.M., Zhu N. and Yam V.W.W., Synthesis and luminescence behaviour of mixed-metal rhenium(I)-copper(I) and -silver(I) alkynyl complexes, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Miss Wing Yin Lo). 2004, P-39.

Lu X., Tang H.S., Ko C.C., Wong K.Y., Zhu N. and Yam V.W.W., Anion-assisted trans-cis isomerization of palladium(II) phosphine complexes containing acetanilide functionalities through hydrogen bonding interactions, Chemical Communications. 2005, 1572-1574.

Mao Z., Huang J.S., Che C.M., Zhu N., Leung K.Y. and Zhou Z.Y., Unexpected reactivities of Cu₂(diphosphine)₂ complexes in alcohol: isolation, x-ray crystal structure, and photoluminescent properties of a remarkably stable [Cu₃(diphosphine)₃(m₃ - H)]²⁺ hydride complex, Journal of the American Chemical Society. 2005, 127(13): 4562-4563.

Tam K.H., Pui Y.L., Zhu N., Chiu P. and Chan M.C.W., Studies of zirconium(IV) polyolefin catalysts bearing tridentate pyridine-2,6-bis(phenolate) auxiliaries with different donor groups, The 229^th National Meeting of the American Chemical Society, San Diego, USA, March 13-17, 2005.

Tang W.S., Wong M.C., Lu X., Zhu N. and Yam V.W.W., Functionalized Platinum(II) Alkynyl Complexes as Colorimetric and Luminescence pH Sensors, The XX IUPAC Symposium on Photochemistry, Granada, Spain (Poster presented by Miss Wing-Suen Tang). 2004.

Tang W.S., Wong M.C., Lu X., Zhu N. and Yam V.W.W., Functionalized platinum(II) alkynyl complexes as colorimetric and luminescence _pH and ion sensors, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Miss Wing Suen Tang). 2004, P-57.

Tao C.H., Zhu N. and Yam V.W.W., Room-temperature phosphorescence and energy transfer in luminescent multinuclear platinum(II) complexes of branched alkynyls, Chemistry - A European Journal. 2005, 11: 1647-1657.

Tao C.H., Wong M.C., Zhu N. and Yam V.W.W., Synthesis, structural characterisation and electrochemical studies of luminescent carbazole-containing platinum(II) and palladium(II) alkynyl complexes, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Mr. Chi Hang Tao). 2004, P-59.

Wong M.C., Zhu X., Hung L.L., Zhu N., Yam V.W.W. and Kwok H.S., A novel class of phosphorescent gold(III) alkynyl-based organic light emitting devices with tunable color, Chemical Communications. 2005, 2906-2908.

Wong M.C., Tang W.S., Lu X., Zhu N. and Yam V.W.W., Functionalized platinum(II) terpyridyl alkynyl complexes as colorimetric and luminescence pH sensors, Inorganic Chemistry. 2005, 44(5): 1492-1498.

Wong M.C., Tang W.S., Chu B.W.K., Zhu N. and Yam V.W.W., Synthesis, photophysical properties, and biomolecular labeling studies of luminescent platinum(II)-terpyridyl alkynyl complexes, Organometallics. 2004, 23(14): 3459-3465.

Xie J., Huang J.S., Zhu N., Zhou Z.Y. and Che C.M., Primary and secondary phosphane complexes of metalloporphyrins: isolation, spectrocscopy, and x-ray crystal structures of ruthenium and osmium porphyrins binding phenyl- or diphenylphosphane, Chemistry - A European Journal. 2005, 11: 2405-2416.

Yam V.W.W., Ko C.C. and Zhu N., Photochromic and luminescence switching properties of a versatile diarylethene-containing 1, 10-phenanthroline ligand and its rhenium(I) complex, Journal of the American Chemical Society. 2004, 126(40): 12734-12735.

Yam V.W.W., Cheung K.L., Yip S.K. and Zhu N., Synthesis, characterization, electrochemistry and luminescence studies of 9-anthrylgold(I) complexes, Photochemical and Photobiological Sciences. 2005, 4: 149-153.

Yam V.W.W., Wong M.C., Hung L.L. and Zhu N., Unprecedented luminescent gold(III) alkynyl complexes - synthesis, structural characterization and luminescent properties, Angewandte Chemie International Edition. 2005, 44: 3107-3110.

Yang D., Gao Q., Zheng B. and Zhu N., Et²ALCL-Promoted asymmetric phenylseleno group transfer radical cyclization reactions of unsaturated b-hydroxy esters, Journal of Organic Chemistry. 2004, 69(25): 8821-8828.

Yang D., Zhang D.W., Hao Y., Wu Y.D., Luo S.W. and Zhu N., b²,³ - Cyclic aminoxy acids:rigid and ring-size-independent building blocks of foldamers, Angewandte Chemie International Edition. 2004, 43: 6719-6722.

Yip S.K., Cheng C.C., Yuan L., Zhu N. and Yam V.W.W., Supramolecular assembly of luminescent gold(I) alkynylcalix[4]crown-6 complexes with planar h² , h² - coordinated gold(I) centers, Angewandte Chemie International Edition. 2004, 43: 4954-4957.

Yip S.K., Cheung K.L., Yuan L., Cheung K.K., Zhu N. and Yam V.W.W., Synthesis, luminescence and ion-binding properties of gold(I) alkynylcalix[4]crown complexes, Abstract in the 15th International Symposium on Photochemistry and Photophysics of Coordination Compounds (15th ISPPCC), Hong Kong, China, July 4-9, 2004 (Poster presented by Mr. Sung Kong Yip). 2004, P-79.

Zhang J., Liang J., Sun X., Zhou H., Zhu N., Zhou Z.Y., Chan P.W.H. and Che C.M., Chiral osmium complexes with sterically bulky schiff-base lignads. Crystal structures of Os(IV) derivatives and the reactivity and catalytic cyclopropanation of alkenes with EDA, Inorganic Chemistry. 2005, 44: 3942-3954.

Researcher : Zhu P

List of Research Outputs

Chan P.Y., Zhu P. and Phillips D.L., Transient resonance raman and density functional theory study of the 7-bromo-2-fluorenylnitrenium cation, Research on Chemical Intermediates. 2005, 31(1-3): 73-84.

Researcher : Zu Y

Project Title:	Perfluorinated surfactant-covered electrode: characterization and applications in electrochemistry and electrogenerated chemiluminescence
Investigator(s):	Zu Y
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004
Completion Date:	02/2005

Abstract:

To develop a new strategy to modify the electrode surface and control (facilitate or inhibit) the electron-transfer reactions.

Project Title:	Development of a New Class of Chemosensor Based on the Electrogenerated Chemiluminescence of Metal Complex with Crown Ether Moiety
Investigator(s):	Zu Y, Yam VWW
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	10/2004

Abstract:

To design and synthesize a series of luminescent metal complexes with crown ether moieties; to investigate the photophysical, electrochemical and ECL properties of the new compounds and their responses upon binding with various metal cations.

Project Title:	Development of a New Class of Chemosensor Based on the Electrogenerated Chemiluminescence of Metal Complex with Crown Ether Moiety
Investigator(s):	Zu Y
Department:	Chemistry
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

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Project Title:	Electrochemiluminescent Chemosensor Based on a Novel Mechanism
Investigator(s):	Zu Y
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2005

Abstract:

We plan to develop a new type of electrochemiluminescent (ECL) chemosensor on the basis of quenching effects of the analytes on a novel emission route of the coreactant ECL system. Unlike the conventional luminescence quenching which is due to the electron or energy transfer between the luminophor excited state and the quencher species, the quenching effect used here results from the interception of the ECL intermediate radicals by the analyte molecules. Our recent experimental results revealed that the ECL signal of the [Ru(bpy)3]2+/TPrA system via the low-oxidation-potential (LOP) route is highly sensitive to the presence of reducible species, such as oxygen. In this proposal, detailed investigation of the novel ECL quenching effect will be conducted, and the possibility of utilizing this effect in reducible-species sensing will be explored, aiming at the development of a new type of ECL chemosensor.The key issues of this study are:1. To study the novel quenching effects of various reducible species on coreactant ECL systems. First, the study will focus on the [Ru(bpy)3]2+/TPrA system. It is generally accepted that the formation of the excited state is via the electron-transfer between [Ru(bpy)3]3+ and highly reducing TPrA free radical generated upon TPrA oxidation. The ECL signal could be quenched by species that is able to intercept the intermediate radical before it joins in the ECL reaction. Longer lifetime of the radical species and higher reaction rate of the radical with quenchers will lead to more efficient quenching. The literature studies of the ECL mechanism of the [Ru(bpy)3]2+/TPrA system have revealed three emission routes, i.e. catalytic route, direct coreactant oxidation route and LOP ECL route. The lifetime of the TPrA free radical may be different in each case. As indicated in our recent work of the oxygen effects on coreactant ECL, the quenching efficiency is much higher for the LOP ECL route as compared with those for the other two routes, suggesting the longer lifetime of TPrA free radical in the LOP ECL process. Therefore, the LOP ECL of the [Ru(bpy)3]2+/TPrA system is expected to be an ideal emission signal sensitive to reducible species in solution. The quenching effects of various reducible species (such as oxygen, metal cations, benzoquinone, et al) on the LOP ECL signal will be investigated.The recent study of the PI’s group has revealed that a strong and reproducible LOP ECL signal of the [Ru(bpy)3]2+/TPrA system can be obtained at a nonionic fluorosurfactant (FSN)-modified gold electrode. This makes it feasible to employ the LOP ECL signal in quantitative analysis. Secondly, we will explore the quenching effects on the coreactant ECL systems other than [Ru(bpy)3]2+/TPrA. For example, other trialkylamines (such as triethylamine and trimethylamine) and some organic acid (such as oxalate) can also be employed as ECL coreactants. The quenching behavior of these systems will be examined and compared with that of the [Ru(bpy)3]2+/TPrA system. This study may lead to a better understanding of the novel quenching process. 2. To develop a new type of ECL chemosensor based on the quenching effect of the analyte on LOP ECL signal.On the basis of the above studies, we will develop practical chemosensors for some analytes of interest using a flow-injection system coupled by an ECL detector. The auto-controllable flow-injection system will be established to achieve good reproducibility of the ECL measurement. Since the modification of the gold electrode with nonionic fluorosurfactant molecules is based on the physical adsorption, it is feasible to clean and modify the electrode in situ. If a microelectrode array is used for the ECL detection, the whole sensor system may be minimized, and a chip-based analytical method may be achieved.

List of Research Outputs

Zheng H. and Zu Y., Emission of Tris(2,2'-bipyridine)ruthenium(II) by coreactant electrogenerated chemiluminescence: from O₂-insensitive to highly O₂-Sensitive , Journal of Physical Chemistry B. American Chemical Society, 2005, 109: 12049-12053.

Zu Y. and Li F., NADH oxidation at fluorosurfactant-covered metal electrodes , 2004 Joint International Meeting (206th Meeting of The Electrochemical Society and 2004 Fall Meeting of The Electrochemical Society of Japan). 2004, 2209.

Zu Y. and Zheng H., Oxygen effect on coreactant electrogenerated chemiluminescence , 5th Asian Conference on Electrochemistry ( ACEC 2005). 2005.

Researcher : Zuo P

List of Research Outputs

Ma C., Zuo P., Kwok W.M., Chan W.S., Kan T.W., Toy P.H. and Phillips D.L., Time-resolved resonance raman study of the triplet states of p-hydroxyacetophenone and the p-hydroxyphenacyl diethyl phosphate phototrigger compound, Journal of Organic Chemistry. 2004, 69(20): 6641-6657.

Ma C., Kwok W.M., Chan W.S., Zuo P., Kan T.W., Toy P.H. and Phillips D.L., Ultrafast time-resolved study of photophysical processes involved in the photodeprotection of p-Hydroxyphenacyl caged phototrigger compounds, Journal of the American Chemical Society. 2005, 127(5): 1463-1472.

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