DEPT OF PHYSIOLOGY
| Researcher : Ao Q |
| List of Research Outputs |
| Ao Q., Fung C.K., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Chitosan Conduits Seeded With Bone Marrow Stromal Cell-derived Schwann Cells Enhance Regeneration Of Rat Sciatic Nerve, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 65. 2010. |
| Ao Q., Fung C.K., Tsui Y.P., Cai S., Zou H.C., Chan Y.S. and Shum D.K.Y., The regeneration of transected sciatic nerves of adult rats using chitosan nerve conduits seeded with bone marrow stromal cell-derived Schwann cells, Biomaterials. 2011, 32: 787-796. |
| Cai S., Ao Q., Chan Y.S. and Shum D.K.Y., Migration of mesenchymal stem cells to injured spinal cord through interaction of SDF-1/ CXCR4, Annals Neuroscience, 17: 103. [5th Congress of Federation of Asian-Oceanian Neuroscience Societies. Lucknow, India. Nov. 25-28, 2010]. 2010. |
| Cai S., Tsui Y.P., Shea G.K.H., Ao Q., Shum D.K.Y. and Chan Y.S., Migration of mesenchymal stem cells to injured spinal cord through interaction of SDF-1/CXCR4, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 49. [HK. March 5-6, 2011]. 2011. |
| Researcher : Ballard HJ |
| Project Title: | Cystic fibrosis transmembrane conductance regulator in ATP efflux from muscle cells |
| Investigator(s): | Ballard HJ |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2008 |
| Completion Date: | 11/2010 |
| Project Title: | Interaction between K-ATP channel and CFTR in ATP efflux from muscle |
| Investigator(s): | Ballard HJ |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2009 |
| Completion Date: | 09/2011 |
| Project Title: | Involvement of cystic fibrosis transmembrane conductance regulator (CFTR) in exercise-induced ATP release |
| Investigator(s): | Ballard HJ |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 02/2011 |
| List of Research Outputs |
| Cai W., Ng F.K. and Ballard H.J., Involvement Of CFTR In ATP Release From Contracting Skeletal Muscle In Anaesthetised Rats, Journal of the Hong Kong College of Cardiology. Hong Kong, Medcom Ltd, 2010, 18: 67. |
| Lu L., Li G.R. and Ballard H.J., Identification Of Channels On Skeletal Myoblasts That May Contribute To Acidosis-Induced ATP Release, Journal of the Hong Kong College of Cardiology. Hong Kong, Medcom Ltd, 2010, 18: 64. |
| Lu L., Li G.R. and Ballard H.J., Identification of channels on skeletal myoblasts that may contribute to acidosis-induced ATP release, J HK Coll Cardiol. 2010. 18(2): 64. |
| Lu L., Li G. and Ballard H.J., The Identification of Chloride Channels on Skeletal Myoblasts, Omics Meets Cell Biology, May 2011. Alpbach Congress Centrum. Alpbach, Austria. 2011, 213. |
| Tu J., Le G. and Ballard H.J., Involvement of the cystic fibrosis transmembrane conductance regulator in the acidosis-induced efflux of ATP from rat skeletal muscle., Journal of Physiology. UK, The Physiological Society, 2010, 588: 4563-4578. |
| Researcher : Bourreau JP |
| Project Title: | Role of cyclooxygenase in the ventricular effects of adrenomedullin: does prostacyclin contribute towards the cardiodepression in the late hypodynamic phase of septic shock? |
| Investigator(s): | Bourreau JP |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Project Title: | Endothelim-dependent hyperpolarization and relaxation of vascular smooth muscle: influence of the mode of excitation-coupling of vasoconstrictors |
| Investigator(s): | Bourreau JP |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 02/2005 |
| Project Title: | Switch in G-protein coupling. Role of intracellular cAMP |
| Investigator(s): | Bourreau JP |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2006 |
| Researcher : Cai S |
| List of Research Outputs |
| Ao Q., Fung C.K., Tsui Y.P., Cai S., Zou H.C., Chan Y.S. and Shum D.K.Y., The regeneration of transected sciatic nerves of adult rats using chitosan nerve conduits seeded with bone marrow stromal cell-derived Schwann cells, Biomaterials. 2011, 32: 787-796. |
| Cai S., Ao Q., Chan Y.S. and Shum D.K.Y., Migration of mesenchymal stem cells to injured spinal cord through interaction of SDF-1/ CXCR4, Annals Neuroscience, 17: 103. [5th Congress of Federation of Asian-Oceanian Neuroscience Societies. Lucknow, India. Nov. 25-28, 2010]. 2010. |
| Cai S., Tsui Y.P., Shea G.K.H., Ao Q., Shum D.K.Y. and Chan Y.S., Migration of mesenchymal stem cells to injured spinal cord through interaction of SDF-1/CXCR4, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 49. [HK. March 5-6, 2011]. 2011. |
| Researcher : Cai W |
| List of Research Outputs |
| Cai W., Ng F.K. and Ballard H.J., Involvement Of CFTR In ATP Release From Contracting Skeletal Muscle In Anaesthetised Rats, Journal of the Hong Kong College of Cardiology. Hong Kong, Medcom Ltd, 2010, 18: 67. |
| Researcher : Cao Z |
| List of Research Outputs |
| Cao Z., Li C., Lai C.H. and Chan Y.S., Change in adult distribution pattern of otolith-related neurons in the inferior olive after perinatal blockade of GABA transmission in the vestibular nucleus, Society of Neuroscience Abstract (USA), 843.8/D15. [San Diego. Nov. 13-17, 2010]. 2010. |
| Cao Z., Li C., Lai C.H. and Chan Y.S., Chronic application of GABA receptor antagonist in the vestibular nucleus alters the distribution of otolith-related neurons in the inferior olive of postnatal rats, Proceedings of CSFR Neuroscience Summit, p. 22-23. [Beijing. Aug. 20-22, 2010]. 2010. |
| Cao Z., Li C., Lai C.H. and Chan Y.S., The effect of blockade of GABA receptor in vestibular nucleus on the otolith-related neurons in the inferior olive during development of rats, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 69. [HK. March 5-6, 2011]. 2011. |
| Researcher : Chan YS |
| Project Title: | 30th Annual Conference of Society for Neuroscience Expression of N-Methyl-D-Aspartate Receptor Subunits and Induction of c-fos in Otolith Neurons in the Vestibular Nuclei of Postnatal Rats |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 11/2000 |
| Project Title: | 31st Annual Meeting of Society for Neuroscience Expression of Neurotrophin Receptors in Vestibular Nuclei During the Postnatal Development of the Rat |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 11/2001 |
| Project Title: | The role of central glial cells in the pathogenesis of Parkinson's Disease |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Project Title: | XXIV Annual Conference of Indian Academy of Neurosciences Development Refinement of Spatial Recognition Circuits |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 12/2006 |
| Project Title: | Postnatal γ-aminobutyric acid transmission is critical for the formation of a three-dimensional spatial map. |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2008 |
| Project Title: | Role of the thalamus in integrating spatial information and guiding navigation |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2009 |
| Project Title: | Determinants of developmental plasticity in the vestibular system |
| Investigator(s): | Chan YS, Shum DKY |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2009 |
| Project Title: | 40th Annual Meeting for Society for Neuroscience Postnatal glutamatergic and GABAergic transmission within the vestibular nucleus is critical for the maturation of canal-related spatial map |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 11/2010 |
| Completion Date: | 11/2010 |
| Project Title: | Outstanding Research Student Supervisor Award 2009-10 |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | Outstanding Research Student Supervisor Award |
| Start Date: | 12/2010 |
| Project Title: | Brain-derived neurotrophic factor regulates plasticity in the vestibular system |
| Investigator(s): | Chan YS, Shum DKY |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2010 |
| List of Research Outputs |
| Ao Q., Fung C.K., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Chitosan Conduits Seeded With Bone Marrow Stromal Cell-derived Schwann Cells Enhance Regeneration Of Rat Sciatic Nerve, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 65. 2010. |
| Ao Q., Fung C.K., Tsui Y.P., Cai S., Zou H.C., Chan Y.S. and Shum D.K.Y., The regeneration of transected sciatic nerves of adult rats using chitosan nerve conduits seeded with bone marrow stromal cell-derived Schwann cells, Biomaterials. 2011, 32: 787-796. |
| Cai S., Ao Q., Chan Y.S. and Shum D.K.Y., Migration of mesenchymal stem cells to injured spinal cord through interaction of SDF-1/ CXCR4, Annals Neuroscience, 17: 103. [5th Congress of Federation of Asian-Oceanian Neuroscience Societies. Lucknow, India. Nov. 25-28, 2010]. 2010. |
| Cai S., Tsui Y.P., Shea G.K.H., Ao Q., Shum D.K.Y. and Chan Y.S., Migration of mesenchymal stem cells to injured spinal cord through interaction of SDF-1/CXCR4, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 49. [HK. March 5-6, 2011]. 2011. |
| Cao Z., Li C., Lai C.H. and Chan Y.S., Change in adult distribution pattern of otolith-related neurons in the inferior olive after perinatal blockade of GABA transmission in the vestibular nucleus, Society of Neuroscience Abstract (USA), 843.8/D15. [San Diego. Nov. 13-17, 2010]. 2010. |
| Cao Z., Li C., Lai C.H. and Chan Y.S., Chronic application of GABA receptor antagonist in the vestibular nucleus alters the distribution of otolith-related neurons in the inferior olive of postnatal rats, Proceedings of CSFR Neuroscience Summit, p. 22-23. [Beijing. Aug. 20-22, 2010]. 2010. |
| Cao Z., Li C., Lai C.H. and Chan Y.S., The effect of blockade of GABA receptor in vestibular nucleus on the otolith-related neurons in the inferior olive during development of rats, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 69. [HK. March 5-6, 2011]. 2011. |
| Cham W.C., Ma C.W., Zhang Y., Xie H., Yung W.H. and Chan Y.S., The role of heparanase in synaptic plasticity at the hippocampus, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 34-35. 2010. |
| Cham W.C., Ma C.W., Zhang Y., Xie H., Yung W.H., Chan Y.S. and Shum D.K.Y., The roles of perineuronal nets and heparanase in synaptic plasticity at the hippocampus, Society of Neuroscience Abstract (USA), 550.19/H30. [San Diego. Nov. 13-17, 2010]. 2010. |
| Chan Y.S., Assembly of brain circuits for spatial representation. Abstracts of Neuroscience Symposium, [Neuroscience Symposium. Sunway, Malaysia. Oct. 13-14, 2010]. 2010, 55-56. |
| Chan Y.S., Lai S.K., Yamaguchi K. and Shum D.K.Y., Attentuation of cerebellar plasticity after neonatal perturbation of NMDA receptors in the vestibular nucleus., Journal of Neurochemistry, 115 (Suppl 1): 29-30. [10th Biennial Meeting of The Asia-Pacific Society for Neurochemistry. Phuket, Thailand. Oct. 17-20, 2010]. 2010. |
| Chan Y.S., Challenges for spatial navigation. Proceedings of CSFR Neuroscience Summit, pp. 10-11, [Beijing. Aug. 20-22, 2010] . 2010. |
| Chan Y.S., Determinants of spatial navigation. Proceedings of 2011 TaiwanHong Kong Physiology Symposium, p. 17. [Chiayi, Taiwan. April 1-2, 2011]. 2011. |
| Chan Y.S., Medical school admission: Principles and strategies. Proc. 2011 East West Alliance Conference – Globalization of Medical Education, p. 16. [Symposium on Medical Education Reform Shantou, China. May 28-29, 2011]. 2011. |
| Chan Y.S., Plasticity of pattern formation for spatial recognition. Annals Neuroscience, 17:9 [5th Congress of Federation of Asian-Oceanian Neuroscience Societies, Lucknow, India. Nov. 25-28, 2010]. 2010. |
| Chan Y.S., Problem-based learning in medical physiology. [Symposium on Application of Problem-based learning in the Teaching of Physiological Sciences, Chiayi, Taiwan. April 2, 2011]. 2011. |
| Chan Y.S., Subcortical contributions to spatial navigation. Abstracts of International Symposium on Brain Aging and Dementia: Basic and Translational Aspects, p. 10, [Varanasi, India. Nov. 29-30, 2010]. 2010. |
| Chan Y.S., ‘When’ and ‘Where’: Acquisition of spatial navigation, Hong Kong Medical Journal 17: 8. [16th Medical Research Conference H.K. Jan. 22, 2011]. 2011. |
| Cheah K.S.E., Au Y.K., Wynn S.A.R.A.H., Chan Y.S., Cheung K.M.C., Chan W...Y..., Lovell-Badge R.H., Chan D. and Fritzsch B..., Molecular and developmental insights into the pathogenesis of the SOX9Y440X campomelic dysplasia mutation., The Fourth Annual Introductory Course on Skeletal Dysplasias, an international course for phycisians and scientists, Freiburg, Germany, 8 July, 2010. |
| Cheah K.S.E., Au Y.K., Szeto Y.Y., Wynn S., Chan Y.S., Cheung K.M.C., Chan W.Y., Lovell-Badge R.H., Chan D. and Fritzsch B., Understanding the molecular pathogenesis of SOX9 Y440X campomelic dysplasia., Academic Symposium on Developmental Studies in Health and Diseases 2010, The Chinese University of Hong Kong, October 18-21, 2010.. 2010. |
| Chen L., Kuang F., Wei L.C., Yung K.K. and Chan Y.S., Potential application of induced pluripotent stell cells in cell replacement therapy for Parkinson’s disease, CNS & Neurological Disorders Drug Targets. 2011, 10: 449-458. |
| Chu J.Y.S., Cheng Y.Y., Lee H.Y.V., Chan Y.S. and Chow B.K.C., Secretin and body fluid homeostasis, Kidney International. 2011, 79(3): 280-287. |
| Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Best Poster Award: Sox10 is essential for inner ear gangliogenesis., 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, June 11, 2011. 2011. |
| Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Cheah K.S.E., Sham M.H. and Chan Y.S., Sox10 is Essential for Gliogenesis of the Cochleo-vestibular Ganglion, 15th Research Postgraduate Symposium, HKU, December 1-2, 2010. |
| Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 is essential for inner ear gangliogenesis., 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, HKU, June 11, 2011. |
| Gao J., Cheung R.T.F., Lee T.M.C., Chu L.W. and Chan Y.S., Task-induced brain deactivation alters the functional connectivity of neural network in aging, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 59-60. 2010. |
| Gao J., Cheung R.T.F., Lee T.M.C., Chu L.W., Cheung C.M., Fung G., Qiu D.Q. and Chan Y.S., The antero-posterior pattern of white matter decline in normal and abnormal ageing supports retrogenesis: a diffusion tensor imaging study, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 58.. 2010. |
| Gao J., Cheung R.T.F., Lee T.M.C., Chu L.W. and Chan Y.S., The effect of normal and abnormal ageing on prospective memory showed increased cognitive conflict: a functional MRI study, Sixteenth Medical Research Conference. 2011, 17 (Suppl 1): 51. |
| Gao J., Cheung R.T.F., Lee T.M.C., Chu L.W. and Chan Y.S., The effect of normal and abnormal ageing on prospective memory showed increased cognitive conflict: a functional MRI study, Hong Kong Medical Journal, 17: 27. [16th Medical Research Conference. H.K. Jan. 22, 2011]. 2011. |
| Gao Y.P., Liu C.H., Chan Y.S. and He J.F., Thalamic reticular nucleus synchronizes spindle oscillation in the thalamocortical network., Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 66. 2010. |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., 5HT2A-mediated facilitation of inhibitory neurotransmission in medial vestibular nucleus, Society of Neuroscience Abstract (USA), 543.6/E24. [San Diego. Nov. 13-17, 2010]. 2010. |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., Electrophysiological study of serotonergic facilitation of inhibitory synaptic transmission in medial vestibular nucleus, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 41. 2010. |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., Selective 5-HT2A receptor facilitation of inhibitory neurotransmission in medial vestibular nucleus, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 62. [HK. March 5-6, 2011]. 2011. |
| Hu H., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Activity-dependent GABAergic synaptic plasticity in medial vestibular neurons of rats, Proceedings of 33rd Annual Meeting of Japan Neuroscience Society: P3-b04. [Kobe, Japan. Sept. 2-4, 2010]. 2010. |
| Hu H., Lai S.K., Lai C.H. and Chan Y.S., Activity-dependent modification of inhibitory synaptic efficacy in medial vestibular neurons of rats, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 44-45. 2010. |
| Hu H., Lai S.K., Lai C.H. and Chan Y.S., Age-dependent GABA-ergic transmission and plasticity in medial vestibular nucleus of rats, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 66. [HK. March 5-6, 2011]. 2011. |
| Hu H., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Developmental plasticity of GABAergic synapses in medial vestibular neurons of rats, Society of Neuroscience Abstract (USA), 141.7/F44. [San Diego. Nov. 13-17, 2010]. 2010. |
| Lai S.K., Yamaguchi K., Yung W.H. and Chan Y.S., Developmental attenuation of cerebellar plasticity after perturbation of glutamate receptors in the vestibular nucleus, Annals Neuroscience, 17: 67-68. [5th Congress of Federation of Asian-Oceanian Neuroscience Societies. Lucknow, India. Nov. 25-28, 2010]. 2010. |
| Lai S.K., Yung W.H., Yamaguchi K. and Chan Y.S., Perinatal perturbation of NMDA receptor I the vestibular nucleus attenuates cerebellar function, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 63-64. 2010. |
| Lai S.K., Yung W.H., Yamaguchi K. and Chan Y.S., Perinatal perturbation of NMDA receptor in the vestibular nucleus attenuates cerebellar function, Acta Physiologica Sinica, 62 (Suppl 1): 49-50. [23rd Congress of The Chinese Association of Physiological Sciences. Xi’an. Oct. 18-21, 2010]. 2010. |
| Lai S.K., Shum D.K.Y., Yung W.H., Yamaguchi K. and Chan Y.S., Perinatal perturbation of NMDA receptor in the vestibular nucleus attenuates cerebellar function, Society of Neuroscience Abstract (USA), 786.17/TT20. [San Diego. Nov. 13-17, 2010]. 2010. |
| Lam Y.L., Cham W.C., Chan Y.S. and Shum D.K.Y., Proheparanase and AMPA receptor trafficking in synaptic plasticity, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 68. [HK. March 5-6, 2011]. 2011. |
| Lau Y.P., Lai C.H. and Chan Y.S., Change in the central vestibular circuitry after perinatal blockade of glutamate transmission in the vestibular nucleus of rats, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 46. 2010. |
| Lau Y.P., Lai C.H. and Chan Y.S., Change in the distribution of gravity-related neuron in the vestibular circuitry after perinatal blockade of glutamate transmission in the vestibular nucleus of rats, Proceedings of 33rd Annual Meeting of Japan Neuroscience Society: P2-i03. [Kobe, Japan. Sept. 2-4, 2010]. 2010. |
| Li M., Chan Y.S. and Shum D.K.Y., Expression of chondroitin sulfotransfgerases in relation to cranial motor neuron migration, Abstracts of 6th International Symposium on on Healthy Aging: A New Golden Age: 67. [HK. March 5-6, 2011]. 2011. |
| Liu C.H., Gao Y.P., Gao L.X., Meng X.K., Yu Y.Q., Chan Y.S. and He J.F., Interaction between spindle oscillations in the thalamic reticular nucleus, auditory thalamus, and cortex., Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 66.. 2010. |
| Liu C.H., Guo Y., Gao L.X., Meng X.K., Yu Y.Q., Chan Y.S. and He J., Spindle-like oscillations in the auditory thalamus and cortex, Society of Neuroscience Abstract (USA), 553.12/I14. [San Diego. Nov. 13-17, 2010]. 2010. |
| Ma C.W., Lai C.H., Chan Y.S. and Shum D.K.Y., Perineuronal net regulates synaptic plasticity of central circuitry, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 60. 2010. |
| Ma C.W., Cham W.C., Lai C.H., Chan Y.S. and Shum D.K.Y., Proheparanase regulates synaptic plasticity of the hippocampus, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 57. [HK. March 5-6, 2011]. 2011. |
| Ng K.P., Lai C.H. and Chan Y.S., Glutamatergic and GABAergic transmission regulate the developmental establishment of canal-related spatial organization, Annals Neuroscience, 17: 59. [5th Congress of Federation of Asian-Oceanian Neuroscience Societies. Lucknow, India. Nov. 25-28, 2010]. 2010. |
| Ng K.P., Lai C.H. and Chan Y.S., Glutamatergic and GABAergic transmission regulate the establishment of functional vestibular circuitry, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 67. [HK. March 5-6, 2011]. 2011. |
| Ng K.P., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Postnatal glutamatergic and GABAergic transmission within the vestibular nucleus is critical for the maturation of canal-related spatial map, Society of Neuroscience Abstract (USA), 843.1/D8. [San Diego. Nov. 13-17, 2010]. 2010. |
| Shea G.K.H., Chan Y.S. and Shum D.K.Y., ErbB receptor modulation controls the fate commitment of bone marrow-derived Schwann cells, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 45. 2010. |
| Shum D.K.Y., Shea G.K.H., Tsui Y.P. and Chan Y.S., Directed differentiation of bone marrow stromal cells to fate commitment of Schwann cells for remyelination therapy. Annals Neuroscience, 17: 27. [5th Congress of Federation of Asian-Oceanian Neuroscience Societies, Lucknow, India. Nov. 25-28, 2010]. 2010. |
| Tai W.Y.E., Shea G.K.H., Leung H.Y., Chan Y.S. and Shum D.K.Y., Cell-intrinsic switch to the fate commitment of bone marrow-derived Schwann cells, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 59. [HK. March 5-6, 2011]. 2011. |
| Tam K.W., Li R.A., Chan Y.S. and Shum D.K.Y., Overcoming axon-restrictive chondroitin supphates with chondroitin sulphate lyases, Abstracts of 6th Int’l Symp. on Healthy Aging: A New Golden Age: 56. 2011. |
| Tam K.W., Li R.A., Chan Y.S. and Shum D.K.Y., Use of chondroitin sulphate lyase subtypes to overcome molecular barriers of reactive glia: Implication for nerve regeneration, Proceedings of CSFR Neuroscience Summit, p. 32-33. [Beijing. Aug. 20-22, 2010]. 2010. |
| Tam K.W., Li R.A., Chan Y.S. and Shum D.K.Y., Use of chondroitin sulphate lyases in combination for achieving maximal activity: Implication for nerve regeneration, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 60-61. 2010. |
| Tsang K.H., Tao K.P., Lai S.K., Chan Y.S. and Chan S.Y., Tspy12 regulates hippocampal long-term potentiation via NMDA receptor subunits NR2A and NR2B expression, Abstracts of 43rd Annual Meeting for the Japanese Society of Developmental Biologists: 286. [Kyoto. June 20-23, 2010]. 2010. |
| Tsui Y.P., Chan Y.S. and Shum D.K.Y., Derivation of oligodendrocyte precursors from bone marrow stromal cells: New perspective in CNS myelin repair, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 61-62. 2010. |
| Tsui Y.P., Chan Y.S. and Shum D.K.Y., Towards Myelin and Functional Recovery in the Injured CNS: Derivation of Oligodendrocyte Precursor Cells from Adult Bone Marrow Stromal Cells , 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Tsui Y.P., Li S.Y., Lo A.C.Y., Chan Y.S. and Shum D.K.Y., Towards functional recovery in the injured CNS: Generating oligodendrocyte precursors from bone marrow stromal cells for remyelination, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 63. [HK. March 5-6, 2011]. 2011. |
| Tsui Y.P., Chan Y.S. and Shum D.K.Y., Towards myelin repair in the CNS: Oligodendrocyte precursors derived from bone marrow stromal cells, Proceedings of 33rd Annual Meeting of Japan Neuroscience Society: P2-e02. [Kobe, Japan. Sept. 2-4, 2010]. 2010. |
| Wong K.K., Li Q., Wong H.T., Tsang K.H., Lai S.K., McAlonan G.M., Chan Y.S. and Chan S.Y., TSPYL2 regulates CREB-Dependent Gene Expression, 44th Annual Meeting of the Japanese Society of Developmental Biologists, Japan, 18-21 May 2011. P2079. |
| Xie H., Leung K.L., Chen L., Chan Y.S., Ng P.C., Fok T.F., Wing Y.K., Ke Y., Li A. and Yung W.H., Brain-derived neurotrophic factor rescues and prevents chronic intermittent hypoxia-induced impairment of hippocampal long-term synaptic plasticity, Neurobiology of Aging. 2010, 40: 155-162. |
| Zhang F.X., Pang Y.W., Zhang M.M., Zhang T., Dong Y.L., Lai C.H., Shum D.K.Y., Chan Y.S., Li J.L. and Li Y.Q., Expression of vesicular glutamate transporters in peripheral vestibular structures and vestibular nuclear complex of rat. , Neuroscience. 2011, 173: 179-189. |
| Researcher : Chen G |
| List of Research Outputs |
| Kong M.C.W., Poon N.Y.E., Yeung H.M., Rushing S.N., Chen G. and Li R.A., MicroRNA-21 promotes survival but not functional maturation of human embryonic stem cell derived cardiomyocytes (hESC-CMs), 16th MRC, HKU. 2010. |
| Researcher : Chen L |
| List of Research Outputs |
| Chen L., Kuang F., Wei L.C., Yung K.K. and Chan Y.S., Potential application of induced pluripotent stell cells in cell replacement therapy for Parkinson’s disease, CNS & Neurological Disorders Drug Targets. 2011, 10: 449-458. |
| Xie H., Leung K.L., Chen L., Chan Y.S., Ng P.C., Fok T.F., Wing Y.K., Ke Y., Li A. and Yung W.H., Brain-derived neurotrophic factor rescues and prevents chronic intermittent hypoxia-induced impairment of hippocampal long-term synaptic plasticity, Neurobiology of Aging. 2010, 40: 155-162. |
| Researcher : Chung SSM |
| List of Research Outputs |
| Cheng L., Yeung P.K.K., Kai A.K.L., Chung S.S.M. and Chung S.K., Role of Epac in the pathogenesis of ischemic stroke, 15th Research Postgraduate Symposium, Dec. 1-2, 2010, The University of Hong Kong, Hong Kong. 2010, 82. |
| Liu J., Chung S.S.M. and Chung S.K., Role of Epac1 in pathogenesis of diabetic retinopathy, 15th Research Postgraduate Symposium, Dec. 1-2, 2010, The University of Hong Kong, Hong Kong. 2010, 87. |
| Yeung P.K.K., Lai K.W., Son H.J., Zhang X., Hwang O., Chung S.S.M. and Chung S.K., Aldose reductase-deficiency leads to more significant loss of dopaminergeric neurons with incresed levels of dopamine, tetrahydrobiopterin and free radical accumulation under experimental Parkinson's Disease condition, Society for Neuroscience 2010. |
| Zhang X., Chung S.S.M. and Chung S.K., Hypertensive mice with over-expression of endothelin-1 show hyperactivity, impaired sensorimotor gating, mild congnitive deficit and cerebral vascular oxidative stress, FENS Abstracts. 2010, 5: 204.9. |
| Researcher : Fung CK |
| List of Research Outputs |
| Ao Q., Fung C.K., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Chitosan Conduits Seeded With Bone Marrow Stromal Cell-derived Schwann Cells Enhance Regeneration Of Rat Sciatic Nerve, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 65. 2010. |
| Ao Q., Fung C.K., Tsui Y.P., Cai S., Zou H.C., Chan Y.S. and Shum D.K.Y., The regeneration of transected sciatic nerves of adult rats using chitosan nerve conduits seeded with bone marrow stromal cell-derived Schwann cells, Biomaterials. 2011, 32: 787-796. |
| Researcher : Fung ML |
| Project Title: | Roles of pro-inflammatory cytokines in the carotid body in intermittent hypoxia |
| Investigator(s): | Fung ML |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2009 |
| Completion Date: | 02/2011 |
| Project Title: | Molecular basis for the inhibition of large conductance calcium-activated potassium channel by chronic intermittent hypoxia |
| Investigator(s): | Fung ML |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2010 |
| Project Title: | Pathophysiological roles of pro-inflammatory cytokines in the carotid body in intermittent hypoxia |
| Investigator(s): | Fung ML, Tipoe GL |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2011 |
| Project Title: | Oxidative stress mediates endothelial dysfunction, vascular inflammation and systemic hypertension in rats with chronic intermittent hypoxia |
| Investigator(s): | Fung ML |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2011 |
| List of Research Outputs |
| Leung T.M., Fung M.L., Liong E.C., Lau T.Y.H., Nanji A.A. and Tipoe G.L., Role of nitric oxide in the regulation of fibrogenic factors in experimental liver fibrosis in mice, Histology and Histopathology. 2011, 26: 201-211. |
| Li J.P., Fung M.L., Li F., Xu A. and Leung W.K., Calcium Signal Facilitates the Immediate Induction of HIF1alpha by Lipopolysaccharide, 24th International Association for Dental Research-SEA Division Annual Scientific Meeting, 9/2010. |
| Lin R., Huang J. and Fung M.L., KIF5b Interaction with NMDA Receptor Mediates NO Production in Neuron, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
| Liu Y. and Fung M.L., Apocynin attenuates oxidative stress and local inflammation in rat adrenal medulla in chronic intermittent hypoxia, The 6th International Symposium on Healthy Aging – A New Golden Age, P39, 3/2011. |
| Liu Y. and Fung M.L., Melatonin attenuates intermittent hypoxia induced oxidative stress and tissue inflammation in rat adrenal medulla, The 14th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, P20, 12/2010. (Journal of the Hong Kong College of Cardiology. 2010, 18(2):76: P20. |
| Liu Y. and Fung M.L., Melatonin prevents oxidative stress and local inflammation in rat adrenal medulla in chronic intermittent hypoxia, 15th Research Postgraduate Symposium, HKU, P2.19, 12/2010. |
| Ng K.M., Chan Y.C., Lee Y.K., Lai W.H., Au K.W., Fung M.L., Siu D.C.W., Li R.A. and Tse H.F., Cobalt Chloride Pretreatment Promotes Cardiac Differentiation of Human Embryonic Stem Cells under atmospheric oxygen level. x, Cell Reprogramming. In press.. 2011. |
| Ng K.M., Chan Y.C., Lee Y.K., Lai W.H., Fung M.L., Siu D.C.W., Li R.A. and Tse H.F., Cobalt chloride pre-treatment enhances the calcium handling of human embryonic stem cells-derived cardiomyocytes, Differentiation, 80:S44 Suppl. 1, 2010. |
| Ng K.M., Lee Y.K., Lai K.W.H., Chan Y.C., Fung M.L., Tse H.F. and Siu D.C.W., Exogenous Expression of Human apoA-I Enhances Cardiac Differentiation of Pluripotent Stem Cells., PLoS One. 2011. |
| Ng K.M., Lau C.F. and Fung M.L., Melatonin reduces hippocampal beta-amyloid generation in rats exposed to chronic intermittent hypoxia, Brain Research. 2010, 1354: 163-171. |
| Ng K.T., Li J., Ng K.M., Tipoe G.L., Leung W.K. and Fung M.L., Expression of hypoxia-inducible factor-1a in human periodontal tissue, Journal of Periodontology. 2011, 82: 136-141. |
| Researcher : Graeff RM |
| Project Title: | Mechanism of the novel Ca2+-signaling pathway mediated by NAADP. |
| Investigator(s): | Graeff RM |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2011 |
| Researcher : Han L |
| List of Research Outputs |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., 5HT2A-mediated facilitation of inhibitory neurotransmission in medial vestibular nucleus, Society of Neuroscience Abstract (USA), 543.6/E24. [San Diego. Nov. 13-17, 2010]. 2010. |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., Electrophysiological study of serotonergic facilitation of inhibitory synaptic transmission in medial vestibular nucleus, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 41. 2010. |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., Selective 5-HT2A receptor facilitation of inhibitory neurotransmission in medial vestibular nucleus, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 62. [HK. March 5-6, 2011]. 2011. |
| Researcher : Hao Q |
| Project Title: | A new method for macromolecular structure determination: envelope-based phasing |
| Investigator(s): | Hao Q |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2009 |
| Project Title: | Structure-based drug design against the influenza virus hemagglutinin |
| Investigator(s): | Hao Q |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 06/2010 |
| Completion Date: | 06/2011 |
| Project Title: | Structural biology of sirtuins |
| Investigator(s): | Hao Q |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2010 |
| List of Research Outputs |
| Dong M., Si Y.Q., Sun S.Y., Pu X.P., Yang Z.J., Zhang L.R., Zhang L.H., Leung C.F.P., Lam M.C., Kwong K.Y., Yue J., Zhou Y., Kriksunov I.A., Hao Q. and Lee H.C., Design, synthesis and biological characterization of novel inhibitors of CD38., Org. Biomol. Chem.. 2011, 9: 3246-3257. |
| Hao Q., Structural Basis for Novel Posttranslational Modifications by Sirtuins, Frontiers in Biomedical Research, Hong Kong. 2010. |
| Zhang H. and Hao Q., Crystal structure of NDM-1 reveals a common β-lactam hydrolysis mechanism, The FASEB Journal. 2011, 25: 2574-2582. |
| Zhang H., Graeff R., Chen Z., Zhang L., Lee H.C. and Hao Q., Dynamic conformations of the CD38-mediated NAD cyclization captured in a single crystal, J Mol Biol. 2011, 405(4): 1070-8. |
| Zhao Y., Zhang H., Lam M.C., Hao Q. and Lee H.C., Cytosolic Cd38 Forms Intact Disulfides And Is Active In Elevating Intracellular Cyclic Adp-ribose., Journal of Biological Chemistry . 2011, 286: 22170-22177. |
| Researcher : Hu H |
| List of Research Outputs |
| Hu H., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Activity-dependent GABAergic synaptic plasticity in medial vestibular neurons of rats, Proceedings of 33rd Annual Meeting of Japan Neuroscience Society: P3-b04. [Kobe, Japan. Sept. 2-4, 2010]. 2010. |
| Hu H., Lai S.K., Lai C.H. and Chan Y.S., Activity-dependent modification of inhibitory synaptic efficacy in medial vestibular neurons of rats, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 44-45. 2010. |
| Hu H., Lai S.K., Lai C.H. and Chan Y.S., Age-dependent GABA-ergic transmission and plasticity in medial vestibular nucleus of rats, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 66. [HK. March 5-6, 2011]. 2011. |
| Hu H., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Developmental plasticity of GABAergic synapses in medial vestibular neurons of rats, Society of Neuroscience Abstract (USA), 141.7/F44. [San Diego. Nov. 13-17, 2010]. 2010. |
| Researcher : Hu H |
| List of Research Outputs |
| Hu H., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Activity-dependent GABAergic synaptic plasticity in medial vestibular neurons of rats, Proceedings of 33rd Annual Meeting of Japan Neuroscience Society: P3-b04. [Kobe, Japan. Sept. 2-4, 2010]. 2010. |
| Hu H., Lai S.K., Lai C.H. and Chan Y.S., Activity-dependent modification of inhibitory synaptic efficacy in medial vestibular neurons of rats, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 44-45. 2010. |
| Hu H., Lai S.K., Lai C.H. and Chan Y.S., Age-dependent GABA-ergic transmission and plasticity in medial vestibular nucleus of rats, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 66. [HK. March 5-6, 2011]. 2011. |
| Hu H., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Developmental plasticity of GABAergic synapses in medial vestibular neurons of rats, Society of Neuroscience Abstract (USA), 141.7/F44. [San Diego. Nov. 13-17, 2010]. 2010. |
| Researcher : Kotaka M |
| Project Title: | Towards the understanding of hyperactivation of RIG-I signalling pathway by influenza A H5N1: Structural studies on interaction of influenza A NS1 protein with TRIM25, an E3 ubiquitin ligase essential for RIG-I activation |
| Investigator(s): | Kotaka M, Hui PY |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2010 |
| Project Title: | Towards the understanding of hyperactivation of RIG-I signalling pathway by influenza A H5N1: Structural studies on influenza A viral RNA recognition and discrimination by RIG-I |
| Investigator(s): | Kotaka M, Hui PY |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2010 |
| Project Title: | Structural determination of Crimean-Congo Haemorraghic Fever viral nucleocapsid protein |
| Investigator(s): | Kotaka M |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2011 |
| List of Research Outputs |
| Waye M.M.Y., Baum L., Boyde T.R.C., Chan K.K.K., Cherny S.S., Choy F., Garcia-Barcelo M.M., Gong Z., Kagawa H., Kotaka M., Lee C.Y., Lee S.M.Y., Li H.Y., Meng H., Ng R.K., Ng T.B., Pollard J., Qi R., Shen D.W., Tam S.S.W., Tsang F.S.Y., Wasylyk B., Xue H. and Siu C.O., Journal of Biochemistry and Molecular Biology in the Post Genomic Era. 2010. |
| Researcher : Lai CH |
| List of Research Outputs |
| Cao Z., Li C., Lai C.H. and Chan Y.S., Change in adult distribution pattern of otolith-related neurons in the inferior olive after perinatal blockade of GABA transmission in the vestibular nucleus, Society of Neuroscience Abstract (USA), 843.8/D15. [San Diego. Nov. 13-17, 2010]. 2010. |
| Cao Z., Li C., Lai C.H. and Chan Y.S., Chronic application of GABA receptor antagonist in the vestibular nucleus alters the distribution of otolith-related neurons in the inferior olive of postnatal rats, Proceedings of CSFR Neuroscience Summit, p. 22-23. [Beijing. Aug. 20-22, 2010]. 2010. |
| Cao Z., Li C., Lai C.H. and Chan Y.S., The effect of blockade of GABA receptor in vestibular nucleus on the otolith-related neurons in the inferior olive during development of rats, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 69. [HK. March 5-6, 2011]. 2011. |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., 5HT2A-mediated facilitation of inhibitory neurotransmission in medial vestibular nucleus, Society of Neuroscience Abstract (USA), 543.6/E24. [San Diego. Nov. 13-17, 2010]. 2010. |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., Electrophysiological study of serotonergic facilitation of inhibitory synaptic transmission in medial vestibular nucleus, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 41. 2010. |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., Selective 5-HT2A receptor facilitation of inhibitory neurotransmission in medial vestibular nucleus, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 62. [HK. March 5-6, 2011]. 2011. |
| Hu H., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Activity-dependent GABAergic synaptic plasticity in medial vestibular neurons of rats, Proceedings of 33rd Annual Meeting of Japan Neuroscience Society: P3-b04. [Kobe, Japan. Sept. 2-4, 2010]. 2010. |
| Hu H., Lai S.K., Lai C.H. and Chan Y.S., Activity-dependent modification of inhibitory synaptic efficacy in medial vestibular neurons of rats, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 44-45. 2010. |
| Hu H., Lai S.K., Lai C.H. and Chan Y.S., Age-dependent GABA-ergic transmission and plasticity in medial vestibular nucleus of rats, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 66. [HK. March 5-6, 2011]. 2011. |
| Hu H., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Developmental plasticity of GABAergic synapses in medial vestibular neurons of rats, Society of Neuroscience Abstract (USA), 141.7/F44. [San Diego. Nov. 13-17, 2010]. 2010. |
| Lau Y.P., Lai C.H. and Chan Y.S., Change in the central vestibular circuitry after perinatal blockade of glutamate transmission in the vestibular nucleus of rats, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 46. 2010. |
| Lau Y.P., Lai C.H. and Chan Y.S., Change in the distribution of gravity-related neuron in the vestibular circuitry after perinatal blockade of glutamate transmission in the vestibular nucleus of rats, Proceedings of 33rd Annual Meeting of Japan Neuroscience Society: P2-i03. [Kobe, Japan. Sept. 2-4, 2010]. 2010. |
| Ma C.W., Lai C.H., Chan Y.S. and Shum D.K.Y., Perineuronal net regulates synaptic plasticity of central circuitry, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 60. 2010. |
| Ma C.W., Cham W.C., Lai C.H., Chan Y.S. and Shum D.K.Y., Proheparanase regulates synaptic plasticity of the hippocampus, Abstracts of 6th Int’l Symp. on Healthy Aging: 57. 2011. |
| Ma C.W., Cham W.C., Lai C.H., Chan Y.S. and Shum D.K.Y., Proheparanase regulates synaptic plasticity of the hippocampus, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 57. [HK. March 5-6, 2011]. 2011. |
| Ng K.P., Lai C.H. and Chan Y.S., Glutamatergic and GABAergic transmission regulate the developmental establishment of canal-related spatial organization, Annals Neuroscience, 17: 59. [5th Congress of Federation of Asian-Oceanian Neuroscience Societies. Lucknow, India. Nov. 25-28, 2010]. 2010. |
| Ng K.P., Lai C.H. and Chan Y.S., Glutamatergic and GABAergic transmission regulate the establishment of functional vestibular circuitry, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 67. [HK. March 5-6, 2011]. 2011. |
| Ng K.P., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Postnatal glutamatergic and GABAergic transmission within the vestibular nucleus is critical for the maturation of canal-related spatial map, Society of Neuroscience Abstract (USA), 843.1/D8. [San Diego. Nov. 13-17, 2010]. 2010. |
| Zhang F.X., Pang Y.W., Zhang M.M., Zhang T., Dong Y.L., Lai C.H., Shum D.K.Y., Chan Y.S., Li J.L. and Li Y.Q., Expression of vesicular glutamate transporters in peripheral vestibular structures and vestibular nuclear complex of rat. , Neuroscience. 2011, 173: 179-189. |
| Researcher : Lai CH |
| List of Research Outputs |
| Cao Z., Li C., Lai C.H. and Chan Y.S., Change in adult distribution pattern of otolith-related neurons in the inferior olive after perinatal blockade of GABA transmission in the vestibular nucleus, Society of Neuroscience Abstract (USA), 843.8/D15. [San Diego. Nov. 13-17, 2010]. 2010. |
| Cao Z., Li C., Lai C.H. and Chan Y.S., Chronic application of GABA receptor antagonist in the vestibular nucleus alters the distribution of otolith-related neurons in the inferior olive of postnatal rats, Proceedings of CSFR Neuroscience Summit, p. 22-23. [Beijing. Aug. 20-22, 2010]. 2010. |
| Cao Z., Li C., Lai C.H. and Chan Y.S., The effect of blockade of GABA receptor in vestibular nucleus on the otolith-related neurons in the inferior olive during development of rats, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 69. [HK. March 5-6, 2011]. 2011. |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., 5HT2A-mediated facilitation of inhibitory neurotransmission in medial vestibular nucleus, Society of Neuroscience Abstract (USA), 543.6/E24. [San Diego. Nov. 13-17, 2010]. 2010. |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., Electrophysiological study of serotonergic facilitation of inhibitory synaptic transmission in medial vestibular nucleus, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 41. 2010. |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., Selective 5-HT2A receptor facilitation of inhibitory neurotransmission in medial vestibular nucleus, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 62. [HK. March 5-6, 2011]. 2011. |
| Hu H., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Activity-dependent GABAergic synaptic plasticity in medial vestibular neurons of rats, Proceedings of 33rd Annual Meeting of Japan Neuroscience Society: P3-b04. [Kobe, Japan. Sept. 2-4, 2010]. 2010. |
| Hu H., Lai S.K., Lai C.H. and Chan Y.S., Activity-dependent modification of inhibitory synaptic efficacy in medial vestibular neurons of rats, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 44-45. 2010. |
| Hu H., Lai S.K., Lai C.H. and Chan Y.S., Age-dependent GABA-ergic transmission and plasticity in medial vestibular nucleus of rats, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 66. [HK. March 5-6, 2011]. 2011. |
| Hu H., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Developmental plasticity of GABAergic synapses in medial vestibular neurons of rats, Society of Neuroscience Abstract (USA), 141.7/F44. [San Diego. Nov. 13-17, 2010]. 2010. |
| Lau Y.P., Lai C.H. and Chan Y.S., Change in the central vestibular circuitry after perinatal blockade of glutamate transmission in the vestibular nucleus of rats, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 46. 2010. |
| Lau Y.P., Lai C.H. and Chan Y.S., Change in the distribution of gravity-related neuron in the vestibular circuitry after perinatal blockade of glutamate transmission in the vestibular nucleus of rats, Proceedings of 33rd Annual Meeting of Japan Neuroscience Society: P2-i03. [Kobe, Japan. Sept. 2-4, 2010]. 2010. |
| Ma C.W., Lai C.H., Chan Y.S. and Shum D.K.Y., Perineuronal net regulates synaptic plasticity of central circuitry, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 60. 2010. |
| Ma C.W., Cham W.C., Lai C.H., Chan Y.S. and Shum D.K.Y., Proheparanase regulates synaptic plasticity of the hippocampus, Abstracts of 6th Int’l Symp. on Healthy Aging: 57. 2011. |
| Ma C.W., Cham W.C., Lai C.H., Chan Y.S. and Shum D.K.Y., Proheparanase regulates synaptic plasticity of the hippocampus, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 57. [HK. March 5-6, 2011]. 2011. |
| Ng K.P., Lai C.H. and Chan Y.S., Glutamatergic and GABAergic transmission regulate the developmental establishment of canal-related spatial organization, Annals Neuroscience, 17: 59. [5th Congress of Federation of Asian-Oceanian Neuroscience Societies. Lucknow, India. Nov. 25-28, 2010]. 2010. |
| Ng K.P., Lai C.H. and Chan Y.S., Glutamatergic and GABAergic transmission regulate the establishment of functional vestibular circuitry, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 67. [HK. March 5-6, 2011]. 2011. |
| Ng K.P., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Postnatal glutamatergic and GABAergic transmission within the vestibular nucleus is critical for the maturation of canal-related spatial map, Society of Neuroscience Abstract (USA), 843.1/D8. [San Diego. Nov. 13-17, 2010]. 2010. |
| Zhang F.X., Pang Y.W., Zhang M.M., Zhang T., Dong Y.L., Lai C.H., Shum D.K.Y., Chan Y.S., Li J.L. and Li Y.Q., Expression of vesicular glutamate transporters in peripheral vestibular structures and vestibular nuclear complex of rat. , Neuroscience. 2011, 173: 179-189. |
| Researcher : Lai SK |
| Project Title: | The 40th Annual Meeting of the Society for Neuroscience (Neuroscience 2010) Perinatal perturbation of NMDA receptor in the vestibular nucleus attenuates cerebellar function |
| Investigator(s): | Lai SK |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 11/2010 |
| Completion Date: | 11/2010 |
| List of Research Outputs |
| Chan Y.S., Lai S.K., Yamaguchi K. and Shum D.K.Y., Attentuation of cerebellar plasticity after neonatal perturbation of NMDA receptors in the vestibular nucleus., Journal of Neurochemistry, 115 (Suppl 1): 29-30. [10th Biennial Meeting of The Asia-Pacific Society for Neurochemistry. Phuket, Thailand. Oct. 17-20, 2010]. 2010. |
| Choi W.M., Lai S.K., Lau E.Y.Y. and Li A.M., Working memory and academic achievement in Chinese children with obstructive sleep apnea. , 30th Annual Conference of the National Academy of Neuropsychology . 2010. |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., 5HT2A-mediated facilitation of inhibitory neurotransmission in medial vestibular nucleus, Society of Neuroscience Abstract (USA), 543.6/E24. [San Diego. Nov. 13-17, 2010]. 2010. |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., Electrophysiological study of serotonergic facilitation of inhibitory synaptic transmission in medial vestibular nucleus, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 41. 2010. |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., Selective 5-HT2A receptor facilitation of inhibitory neurotransmission in medial vestibular nucleus, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 62. [HK. March 5-6, 2011]. 2011. |
| Hu H., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Activity-dependent GABAergic synaptic plasticity in medial vestibular neurons of rats, Proceedings of 33rd Annual Meeting of Japan Neuroscience Society: P3-b04. [Kobe, Japan. Sept. 2-4, 2010]. 2010. |
| Hu H., Lai S.K., Lai C.H. and Chan Y.S., Activity-dependent modification of inhibitory synaptic efficacy in medial vestibular neurons of rats, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 44-45. 2010. |
| Hu H., Lai S.K., Lai C.H. and Chan Y.S., Age-dependent GABA-ergic transmission and plasticity in medial vestibular nucleus of rats, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 66. [HK. March 5-6, 2011]. 2011. |
| Hu H., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Developmental plasticity of GABAergic synapses in medial vestibular neurons of rats, Society of Neuroscience Abstract (USA), 141.7/F44. [San Diego. Nov. 13-17, 2010]. 2010. |
| Lai S.K., Yamaguchi K., Yung W.H. and Chan Y.S., Developmental attenuation of cerebellar plasticity after perturbation of glutamate receptors in the vestibular nucleus, Annals Neuroscience, 17: 67-68. [5th Congress of Federation of Asian-Oceanian Neuroscience Societies. Lucknow, India. Nov. 25-28, 2010]. 2010. |
| Lai S.K., Yung W.H., Yamaguchi K. and Chan Y.S., Perinatal perturbation of NMDA receptor I the vestibular nucleus attenuates cerebellar function, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 63-64. 2010. |
| Lai S.K., Yung W.H., Yamaguchi K. and Chan Y.S., Perinatal perturbation of NMDA receptor in the vestibular nucleus attenuates cerebellar function, Acta Physiologica Sinica, 62 (Suppl 1): 49-50. [23rd Congress of The Chinese Association of Physiological Sciences. Xi’an. Oct. 18-21, 2010]. 2010. |
| Lai S.K., Shum D.K.Y., Yung W.H., Yamaguchi K. and Chan Y.S., Perinatal perturbation of NMDA receptor in the vestibular nucleus attenuates cerebellar function, Society of Neuroscience Abstract (USA), 786.17/TT20. [San Diego. Nov. 13-17, 2010]. 2010. |
| Lau E.Y.Y., Li A.M. and Lai S.K., Working memory in children with obstructive sleep apnea., 40th Annual Meeting of the Society for Neuroscience. 2010. |
| Ng K.P., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Postnatal glutamatergic and GABAergic transmission within the vestibular nucleus is critical for the maturation of canal-related spatial map, Society of Neuroscience Abstract (USA), 843.1/D8. [San Diego. Nov. 13-17, 2010]. 2010. |
| Tsang K.H., Tao K.P., Lai S.K., Chan Y.S. and Chan S.Y., Tspy12 regulates hippocampal long-term potentiation via NMDA receptor subunits NR2A and NR2B expression, Abstracts of 43rd Annual Meeting for the Japanese Society of Developmental Biologists: 286. [Kyoto. June 20-23, 2010]. 2010. |
| Wong K.K., Li Q., Wong H.T., Tsang K.H., Lai S.K., McAlonan G.M., Chan Y.S. and Chan S.Y., TSPYL2 regulates CREB-Dependent Gene Expression, 44th Annual Meeting of the Japanese Society of Developmental Biologists, Japan, 18-21 May 2011. P2079. |
| Researcher : Lam MC |
| List of Research Outputs |
| Dong M., Si Y.Q., Sun S.Y., Pu X.P., Yang Z.J., Zhang L.R., Zhang L.H., Leung C.F.P., Lam M.C., Kwong K.Y., Yue J., Zhou Y., Kriksunov I.A., Hao Q. and Lee H.C., Design, synthesis and biological characterization of novel inhibitors of CD38., Org. Biomol. Chem.. 2011, 9: 3246-3257. |
| Zhao Y., Zhang H., Lam M.C., Hao Q. and Lee H.C., Cytosolic Cd38 Forms Intact Disulfides And Is Active In Elevating Intracellular Cyclic Adp-ribose., Journal of Biological Chemistry . 2011, 286: 22170-22177. |
| Researcher : Lau CF |
| List of Research Outputs |
| Ng K.M., Lau C.F. and Fung M.L., Melatonin reduces hippocampal beta-amyloid generation in rats exposed to chronic intermittent hypoxia, Brain Research. 2010, 1354: 163-171. |
| Researcher : Lau YP |
| List of Research Outputs |
| Lau Y.P., Lai C.H. and Chan Y.S., Change in the central vestibular circuitry after perinatal blockade of glutamate transmission in the vestibular nucleus of rats, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 46. 2010. |
| Lau Y.P., Lai C.H. and Chan Y.S., Change in the distribution of gravity-related neuron in the vestibular circuitry after perinatal blockade of glutamate transmission in the vestibular nucleus of rats, Proceedings of 33rd Annual Meeting of Japan Neuroscience Society: P2-i03. [Kobe, Japan. Sept. 2-4, 2010]. 2010. |
| Researcher : Le G |
| List of Research Outputs |
| Tu J., Le G. and Ballard H.J., Involvement of the cystic fibrosis transmembrane conductance regulator in the acidosis-induced efflux of ATP from rat skeletal muscle., Journal of Physiology. UK, The Physiological Society, 2010, 588: 4563-4578. |
| Researcher : Lee HC |
| Project Title: | A calcium-signaling pathway mediated by cyclic ADP-ribose and NAADP |
| Investigator(s): | Lee HC |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 08/2007 |
| Completion Date: | 07/2010 |
| Project Title: | Chemical synthesis and biological characterizations of antagonists of a novel calcium signaling enzyme - CD38 |
| Investigator(s): | Lee HC |
| Department: | Physiology |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2009 |
| Project Title: | Systemic modulation of cardiovascular functions by a Ca2+ messenger - Cyclic ADP-ribose |
| Investigator(s): | Lee HC, Wong TM |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2009 |
| Project Title: | Structure and Function of the ADP-ribosyl Cyclases. |
| Investigator(s): | Lee HC, Hao Q, Li GR |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2010 |
| Project Title: | Regulation of the Calcium Messenger Cyclic ADP-ribose. |
| Investigator(s): | Lee HC |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2011 |
| List of Research Outputs |
| Dong M., Si Y.Q., Sun S.Y., Pu X.P., Yang Z.J., Zhang L.R., Zhang L.H., Leung C.F.P., Lam M.C., Kwong K.Y., Yue J., Zhou Y., Kriksunov I.A., Hao Q. and Lee H.C., Design, synthesis and biological characterization of novel inhibitors of CD38., Org. Biomol. Chem.. 2011, 9: 3246-3257. |
| Tao R., Sun H., Lau C.P., Tse H.F., Lee H.C. and Li G.R., Cyclic ADP ribose is a novel regulator of intracellular Ca(2+) oscillations in human bone marrow mesenchymal stem cells. , J Cell Mol Med. 2011, 15(12): 2684-96. |
| Tao R., Lee H.C. and Li G.R., Cyclic ADP ribose is a novel regulator of intracellular Ca2+ oscillations in human bone marrow mesenchymal stem cells, New Horizons in Calcium Signaling. Oct, 2010. Beijing, China. 2010, p173. |
| Zhang H., Graeff R., Chen Z., Zhang L., Lee H.C. and Hao Q., Dynamic conformations of the CD38-mediated NAD cyclization captured in a single crystal, J Mol Biol. 2011, 405(4): 1070-8. |
| Zhao Y., Zhang H., Lam M.C., Hao Q. and Lee H.C., Cytosolic Cd38 Forms Intact Disulfides And Is Active In Elevating Intracellular Cyclic Adp-ribose., Journal of Biological Chemistry . 2011, 286: 22170-22177. |
| Researcher : Leung CFP |
| Project Title: | Regulation of CD38 in abscisic acid-activated human monocytes. |
| Investigator(s): | Leung CFP, Lee HC |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2009 |
| List of Research Outputs |
| Chan Y.C., Leung C.F.P., Yung L.M., Lau C.W., Chen Z.Y., Yao X.Q., Laher I. and Huang Y., Raloxifene improves vascular reactivity in pressurized septal coronary arteries of ovariectomized hamsters fed cholesterol diet, Pharmacological Research (under review). 2010. |
| Dong M., Si Y.Q., Sun S.Y., Pu X.P., Yang Z.J., Zhang L.R., Zhang L.H., Leung C.F.P., Lam M.C., Kwong K.Y., Yue J., Zhou Y., Kriksunov I.A., Hao Q. and Lee H.C., Design, synthesis and biological characterization of novel inhibitors of CD38., Org. Biomol. Chem.. 2011, 9: 3246-3257. |
| Researcher : Li C |
| List of Research Outputs |
| Cao Z., Li C., Lai C.H. and Chan Y.S., Change in adult distribution pattern of otolith-related neurons in the inferior olive after perinatal blockade of GABA transmission in the vestibular nucleus, Society of Neuroscience Abstract (USA), 843.8/D15. [San Diego. Nov. 13-17, 2010]. 2010. |
| Cao Z., Li C., Lai C.H. and Chan Y.S., Chronic application of GABA receptor antagonist in the vestibular nucleus alters the distribution of otolith-related neurons in the inferior olive of postnatal rats, Proceedings of CSFR Neuroscience Summit, p. 22-23. [Beijing. Aug. 20-22, 2010]. 2010. |
| Cao Z., Li C., Lai C.H. and Chan Y.S., The effect of blockade of GABA receptor in vestibular nucleus on the otolith-related neurons in the inferior olive during development of rats, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 69. [HK. March 5-6, 2011]. 2011. |
| Researcher : Li GR |
| Project Title: | Volume-sensitive chloride current and cell volume regulation in human atrial myocytes |
| Investigator(s): | Li GR, Lau CP, Chiu SW, Tse HF |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2001 |
| Project Title: | Calcium Signals and Cell Proliferation in Human Cardiac Fibroblasts |
| Investigator(s): | Li GR, Lau CP, Lee HC, Tse HF |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2009 |
| Project Title: | Study on the Natural Anti-Atrial Fibrillation Compound Acacetin and Its Analogues/Derivatives |
| Investigator(s): | Li GR, Vanhoutte PMGR |
| Department: | Medicine |
| Source(s) of Funding: | Innovation and Technology Support Programme (Tier 3) |
| Start Date: | 03/2010 |
| Project Title: | Human Atrial IKur/hKv1.5 and Protein Tyrosine Kinase Regulation |
| Investigator(s): | Li GR |
| Department: | Medicine |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2010 |
| Completion Date: | 09/2011 |
| Project Title: | ISSCR 9th Annual Meeting BOTH ION CHANNELS AND CALCIUM SIGNALS REGULATE PROLIFERATION IN HUMAN ADULT MESENCHYMAL STEM CELLS FROM BONE MARROW |
| Investigator(s): | Li GR |
| Department: | Medicine |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 06/2011 |
| Completion Date: | 06/2011 |
| List of Research Outputs |
| Lu L., Li G.R. and Ballard H.J., Identification Of Channels On Skeletal Myoblasts That May Contribute To Acidosis-Induced ATP Release, Journal of the Hong Kong College of Cardiology. Hong Kong, Medcom Ltd, 2010, 18: 64. |
| Researcher : Li L |
| List of Research Outputs |
| Li L., Tang F. and O W.S., Coexpression of adrenomedullin and its receptor component proteins in the reproductive system of the rat during gestation, Reproductive Biology and Endocrinology. 2010, 8: 130-142. |
| O W.S., Li L. and Tang F., Adrenomedullin in the rat ovary: Its production, interaction with endothelin 1, and actions on progesterone secretion during gestation, Abstracts of the Society for the Study of Reproduction, 43rd Annual Meeting, 2010. 137 606. |
| Researcher : Liu CH |
| List of Research Outputs |
| Gao Y.P., Liu C.H., Chan Y.S. and He J.F., Thalamic reticular nucleus synchronizes spindle oscillation in the thalamocortical network., Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 66. 2010. |
| Liu C.H., Gao Y.P., Gao L.X., Meng X.K., Yu Y.Q., Chan Y.S. and He J.F., Interaction between spindle oscillations in the thalamic reticular nucleus, auditory thalamus, and cortex., Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 66.. 2010. |
| Liu C.H., Guo Y., Gao L.X., Meng X.K., Yu Y.Q., Chan Y.S. and He J., Spindle-like oscillations in the auditory thalamus and cortex, Society of Neuroscience Abstract (USA), 553.12/I14. [San Diego. Nov. 13-17, 2010]. 2010. |
| Researcher : Liu Y |
| List of Research Outputs |
| Liu Y. and Fung M.L., Apocynin attenuates oxidative stress and local inflammation in rat adrenal medulla in chronic intermittent hypoxia, The 6th International Symposium on Healthy Aging – A New Golden Age, P39, 3/2011. |
| Liu Y. and Fung M.L., Melatonin attenuates intermittent hypoxia induced oxidative stress and tissue inflammation in rat adrenal medulla, The 14th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, P20, 12/2010. (Journal of the Hong Kong College of Cardiology. 2010, 18(2):76: P20. |
| Liu Y. and Fung M.L., Melatonin prevents oxidative stress and local inflammation in rat adrenal medulla in chronic intermittent hypoxia, 15th Research Postgraduate Symposium, HKU, P2.19, 12/2010. |
| Researcher : Lu L |
| List of Research Outputs |
| Lu L., Li G.R. and Ballard H.J., Identification Of Channels On Skeletal Myoblasts That May Contribute To Acidosis-Induced ATP Release, Journal of the Hong Kong College of Cardiology. Hong Kong, Medcom Ltd, 2010, 18: 64. |
| Lu L., Li G.R. and Ballard H.J., Identification of channels on skeletal myoblasts that may contribute to acidosis-induced ATP release, J HK Coll Cardiol. 2010. 18(2): 64. |
| Lu L., Li G. and Ballard H.J., The Identification of Chloride Channels on Skeletal Myoblasts, Omics Meets Cell Biology, May 2011. Alpbach Congress Centrum. Alpbach, Austria. 2011, 213. |
| Researcher : Lung MAKY |
| Project Title: | Endothelins in nasal mucosa: role in nasal congestion and decongestion |
| Investigator(s): | Lung MAKY |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Project Title: | The therapeutic value of Prostaglandin E2 on nasal congestion in acute experimental rhinitis |
| Investigator(s): | Lung MAKY |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2011 |
| Completion Date: | 11/2011 |
| List of Research Outputs |
| Lung M.A.K.Y., M1 and M3 muscarinic receptors mediate relaxation and contraction in canine nasal veins, Anerican Jounral of Rhinology and Allergy. U.S.A., OceanSide Publications, 2011, 25: e60-e65. |
| Researcher : Lung MKY |
| Project Title: | Endothelins in nasal mucosa: role in nasal congestion and decongestion |
| Investigator(s): | Lung MAKY |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Project Title: | The therapeutic value of Prostaglandin E2 on nasal congestion in acute experimental rhinitis |
| Investigator(s): | Lung MAKY |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2011 |
| Completion Date: | 11/2011 |
| List of Research Outputs |
| Researcher : Ma CW |
| List of Research Outputs |
| Cham W.C., Ma C.W., Zhang Y., Xie H., Yung W.H. and Chan Y.S., The role of heparanase in synaptic plasticity at the hippocampus, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 34-35. 2010. |
| Cham W.C., Ma C.W., Zhang Y., Xie H., Yung W.H., Chan Y.S. and Shum D.K.Y., The roles of perineuronal nets and heparanase in synaptic plasticity at the hippocampus, Society of Neuroscience Abstract (USA), 550.19/H30. [San Diego. Nov. 13-17, 2010]. 2010. |
| Ma C.W., Lai C.H., Chan Y.S. and Shum D.K.Y., Perineuronal net regulates synaptic plasticity of central circuitry, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 60. 2010. |
| Ma C.W., Cham W.C., Lai C.H., Chan Y.S. and Shum D.K.Y., Proheparanase regulates synaptic plasticity of the hippocampus, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 57. [HK. March 5-6, 2011]. 2011. |
| Researcher : Ng KM |
| Project Title: | Role of APOA1 in the cardiac differentiation of pluripotent stem cells |
| Investigator(s): | Ng KM, Siu DCW, Tse HF |
| Department: | Medicine |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2010 |
| Project Title: | The 16th International Conference of the International Society of Differentiation (ISD2010) Cobalt Chloride Pre-treatment Enhances the Calcium Handling of Human Embryonic Stem Cells-derived Cardiomyocytes. |
| Investigator(s): | Ng KM |
| Department: | Medicine |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 11/2010 |
| Completion Date: | 11/2010 |
| List of Research Outputs |
| Ng K.M., Chan Y.C., Lee Y.K., Lai W.H., Fung M.L., Siu D.C.W., Li R.A. and Tse H.F., Cobalt chloride pre-treatment enhances the calcium handling of human embryonic stem cells-derived cardiomyocytes, Differentiation, 80:S44 Suppl. 1, 2010. |
| Ng K.M., Lau C.F. and Fung M.L., Melatonin reduces hippocampal beta-amyloid generation in rats exposed to chronic intermittent hypoxia, Brain Research. 2010, 1354: 163-171. |
| Researcher : Ng KP |
| List of Research Outputs |
| Ng K.P., Lai C.H. and Chan Y.S., Glutamatergic and GABAergic transmission regulate the developmental establishment of canal-related spatial organization, Annals Neuroscience, 17: 59. [5th Congress of Federation of Asian-Oceanian Neuroscience Societies. Lucknow, India. Nov. 25-28, 2010]. 2010. |
| Ng K.P., Lai C.H. and Chan Y.S., Glutamatergic and GABAergic transmission regulate the establishment of functional vestibular circuitry, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 67. [HK. March 5-6, 2011]. 2011. |
| Ng K.P., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Postnatal glutamatergic and GABAergic transmission within the vestibular nucleus is critical for the maturation of canal-related spatial map, Society of Neuroscience Abstract (USA), 843.1/D8. [San Diego. Nov. 13-17, 2010]. 2010. |
| Researcher : Pang B |
| List of Research Outputs |
| LIN X.F., Sun J., XI Y.Y. and Pang B., Computational interpretation of the stereoselectivity for a dirhodium tetracarboxylate-catalyzed amidation reaction, COMPUTATIONAL AND THEORETICAL CHEMISTRY. PO BOX 211, 1000 AE AMSTERDAM, NETHERLAN, ELSEVIER SCIENCE BV, 2011, 963: 284-289. |
| Shiu S.Y.W., Pang B., Tam C.W. and Yao K.M., Signal transduction of receptor-mediated antiproliferative action of melatonin on human prostate epithelial cells involves dual activation of Ga(s) and Ga(q) proteins, Journal of Pineal Research. 2010, 49: 301-311. |
| Researcher : Pang B |
| List of Research Outputs |
| LIN X.F., Sun J., XI Y.Y. and Pang B., Computational interpretation of the stereoselectivity for a dirhodium tetracarboxylate-catalyzed amidation reaction, COMPUTATIONAL AND THEORETICAL CHEMISTRY. PO BOX 211, 1000 AE AMSTERDAM, NETHERLAN, ELSEVIER SCIENCE BV, 2011, 963: 284-289. |
| Shiu S.Y.W., Pang B., Tam C.W. and Yao K.M., Signal transduction of receptor-mediated antiproliferative action of melatonin on human prostate epithelial cells involves dual activation of Ga(s) and Ga(q) proteins, Journal of Pineal Research. 2010, 49: 301-311. |
| Researcher : Shiu SYW |
| Project Title: | Transcriptional regulation of p27Kip1 by melatonin in prostate epithelial cells |
| Investigator(s): | Shiu SYW |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2008 |
| Completion Date: | 10/2010 |
| Project Title: | Growth-modulatory effects of the melatonin receptor agonist ramelteon on prostate epithelial cells |
| Investigator(s): | Shiu SYW |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2009 |
| Project Title: | Interactions between melatonin and NF-κB in the regulation of prostate cancer cell growth |
| Investigator(s): | Shiu SYW |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 02/2011 |
| Project Title: | 5th PacRim Breast and Prostate Cancer Meeting 2011 Melatonin as a hormonal drug for the treatment and prevention of prostate cancer: evidence so far |
| Investigator(s): | Shiu SYW |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 05/2011 |
| Completion Date: | 05/2011 |
| List of Research Outputs |
| Shiu S.Y.W., Melatonin as a hormonal drug for the treatment and prevention of prostate cancer: evidence so far, 5th PacRim breast and Prostate Cancer Meeting, Mantra on Salt Beach, Kingscliff, NSW, Australia, 5-7 May. 2011. |
| Shiu S.Y.W., Pang B., Tam C.W. and Yao K.M., Signal transduction of receptor-mediated antiproliferative action of melatonin on human prostate epithelial cells involves dual activation of Ga(s) and Ga(q) proteins, Journal of Pineal Research. 2010, 49: 301-311. |
| Researcher : Tai WYE |
| List of Research Outputs |
| Tai W.Y.E., Shea G.K.H., Leung H.Y., Chan Y.S. and Shum D.K.Y., Cell-intrinsic switch to the fate commitment of bone marrow-derived Schwann cells, Abstracts of 6th International Symposium on Healthy Aging: A New Golden Age: 59. [HK. March 5-6, 2011]. 2011. |
| Researcher : Tam CW |
| List of Research Outputs |
| Shiu S.Y.W., Pang B., Tam C.W. and Yao K.M., Signal transduction of receptor-mediated antiproliferative action of melatonin on human prostate epithelial cells involves dual activation of Ga(s) and Ga(q) proteins, Journal of Pineal Research. 2010, 49: 301-311. |
| Researcher : Tam KV |
| List of Research Outputs |
| Tam K.V., Lau K.W., Lee T.O., Chu J.Y.S., Ng K.M., Fournier A. and Chow B.K.C., Origin of Secretin Receptor Precedes the Advent of Tetrapoda: Evidence on the Separated Origins of Secretin and Orexin, PLoS One. 2011, E19384. |
| Researcher : Tam KW |
| List of Research Outputs |
| Tam K.W., Li R.A., Chan Y.S. and Shum D.K.Y., Overcoming axon-restrictive chondroitin supphates with chondroitin sulphate lyases, Abstracts of 6th Int’l Symp. on Healthy Aging: A New Golden Age: 56. 2011. |
| Tam K.W., Li R.A., Chan Y.S. and Shum D.K.Y., Use of chondroitin sulphate lyase subtypes to overcome molecular barriers of reactive glia: Implication for nerve regeneration, Proceedings of CSFR Neuroscience Summit, p. 32-33. [Beijing. Aug. 20-22, 2010]. 2010. |
| Tam K.W., Li R.A., Chan Y.S. and Shum D.K.Y., Use of chondroitin sulphate lyases in combination for achieving maximal activity: Implication for nerve regeneration, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 60-61. 2010. |
| Researcher : Tang F |
| Project Title: | Adrenomedullin as a new metabolic hormone: its metabolic actions in the skeletal muscles, adipose tissues and liver, interaction with endothelin and other adipokines, and possible roles in metabolic syndrome. |
| Investigator(s): | Tang F, Cheung BMY |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2007 |
| Completion Date: | 02/2011 |
| Project Title: | Adrenomedullin in the male sex acessory glands: gene expression, levels and receptor binding, functions and regulation of production in the prostate, seminal vesicle and coagulating gland. |
| Investigator(s): | Tang F, O WS |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2008 |
| Project Title: | Adrenomedullin gene expression in rats before puberty. |
| Investigator(s): | Tang F |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2008 |
| Completion Date: | 10/2010 |
| Project Title: | Interaction of adrenomedullin and adipocytokines and adipokines in the soleus muscle and epididymal fat pad. |
| Investigator(s): | Tang F, O WS |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2009 |
| Completion Date: | 08/2011 |
| Project Title: | Intermedin (adrenomedullin 2) in the testis: gene expression, physiological actions and regulation of secretion. |
| Investigator(s): | Tang F, O WS |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2010 |
| List of Research Outputs |
| Kong L.H.M., O W.S. and Tang F., Anti-oxidative and anti-inflammatory activities of adrenomedullin (ADM) in the rat uterus, Abstracts of the Society for the Study of Reproduction, 43rd Annual Meeting, 2010. 78 346. |
| Li L., Tang F. and O W.S., Coexpression of adrenomedullin and its receptor component proteins in the reproductive system of the rat during gestation, Reproductive Biology and Endocrinology. 2010, 8: 130-142. |
| Liao S., Ho J.C.M., Tang F. and O W.S., Adrenomedullin increases ciliary beat frequency and decreases muscular contraction in the rat oviduct, Reproduction. 2011, 141: 367-372. |
| O W.S., Li L. and Tang F., Adrenomedullin in the rat ovary: Its production, interaction with endothelin 1, and actions on progesterone secretion during gestation, Abstracts of the Society for the Study of Reproduction, 43rd Annual Meeting, 2010. 137 606. |
| Researcher : Tu J |
| List of Research Outputs |
| Tu J., Le G. and Ballard H.J., Involvement of the cystic fibrosis transmembrane conductance regulator in the acidosis-induced efflux of ATP from rat skeletal muscle., Journal of Physiology. UK, The Physiological Society, 2010, 588: 4563-4578. |
| Researcher : Wong TM |
| Project Title: | First Asia-Pacific Opioid Symposium Cardioprotective Effects of K-Opioids |
| Investigator(s): | Wong TM |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 08/2000 |
| Project Title: | XVIII World Congress International Society for Heart Research in Conjunction with 52nd Annual Scientific Meeting of the Cardiac Society of Australia & New Zealand Delayed Cardioprotection of Kappa Opioid Receptor Stimulation in Normal and Diabetic Rats - Roles of Heat Shock Protein 70 and Intracellular Ca2+ |
| Investigator(s): | Wong TM |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 08/2004 |
| Project Title: | CSANZ 2006 Annual Scientific Meeting Heat Shock Protein 70, Calcium Regulation and Cardiac Survival |
| Investigator(s): | Wong TM |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 08/2006 |
| List of Research Outputs |
| Zhang Y., Lu Y., Mei B., Zhou Y.M., Chen Z.W. and Wong T.M., Intracerebroventricular administration of morphone confers remote cardioprotecion - role of opioid receptors and calmodulin, European J Pharmacology. 2011, 656(1-3): 74-80. |
| Researcher : Xie H |
| List of Research Outputs |
| Cham W.C., Ma C.W., Zhang Y., Xie H., Yung W.H. and Chan Y.S., The role of heparanase in synaptic plasticity at the hippocampus, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 34-35. 2010. |
| Cham W.C., Ma C.W., Zhang Y., Xie H., Yung W.H., Chan Y.S. and Shum D.K.Y., The roles of perineuronal nets and heparanase in synaptic plasticity at the hippocampus, Society Neuroscience Abstract (USA), 550.19/H30. 2010. |
| Cham W.C., Ma C.W., Zhang Y., Xie H., Yung W.H., Chan Y.S. and Shum D.K.Y., The roles of perineuronal nets and heparanase in synaptic plasticity at the hippocampus, Society of Neuroscience Abstract (USA), 550.19/H30. [San Diego. Nov. 13-17, 2010]. 2010. |
| Xie H., Leung K.L., Chen L., Chan Y.S., Ng P.C., Fok T.F., Wing Y.K., Ke Y., Li A. and Yung W.H., Brain-derived neurotrophic factor rescues and prevents chronic intermittent hypoxia-induced impairment of hippocampal long-term synaptic plasticity, Neurobiology of Aging. 2010, 40: 155-162. |
| Researcher : Yue J |
| Project Title: | Identifying novel regulators in cADPR-mediated calcium signaling by combining approaches of synthetic organic chemistry and RNAi screen |
| Investigator(s): | Yue J |
| Department: | Physiology |
| Source(s) of Funding: | Travel Grants for NSFC/RGC JRS |
| Start Date: | 12/2008 |
| Project Title: | The Role and mechanism of cADPR and NAADP in the proliferation and differentiation of neural stem cells |
| Investigator(s): | Yue J, Wu W, Lee HC |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2009 |
| Completion Date: | 02/2011 |
| Project Title: | Mechanism of melamine-induced human urinary bladder carcinoma |
| Investigator(s): | Yue J, Lee HC |
| Department: | Physiology |
| Source(s) of Funding: | Studies Related to Melamine Incident |
| Start Date: | 04/2009 |
| Completion Date: | 02/2011 |
| Project Title: | Dissecting the mechanism and function of the CD38/cADPR/Ca2+ signaling in PC12 cell proliferation and differentiation |
| Investigator(s): | Yue J, Chan YS, Lee HC |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2009 |
| Project Title: | Identifying novel regulators in cADPR-mediated calcium signaling by combining approaches of synthetic organic chemistry and RNAi screen |
| Investigator(s): | Yue J, Lee HC |
| Department: | Physiology |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 12/2009 |
| Project Title: | Modulation of the neural lineage entry of mouse embryonic stem cells by the CD38/cADPR/Ca2+ signaling pathway |
| Investigator(s): | Yue J, Wu W |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2010 |
| Project Title: | Role of the CD38/cADPR/Ca2+ signaling pathway in cardiomyocyte differentiation of mouse embryonic stem cell |
| Investigator(s): | Yue J |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2011 |
| List of Research Outputs |
| Dong M., Si Y.Q., Sun S.Y., Pu X.P., Yang Z.J., Zhang L.R., Zhang L.H., Leung C.F.P., Lam M.C., Kwong K.Y., Yue J., Zhou Y., Kriksunov I.A., Hao Q. and Lee H.C., Design, synthesis and biological characterization of novel inhibitors of CD38., Org. Biomol. Chem.. 2011, 9: 3246-3257. |
| Researcher : Zhang FX |
| List of Research Outputs |
| Zhang F.X., Pang Y.W., Zhang M.M., Zhang T., Dong Y.L., Lai C.H., Shum D.K.Y., Chan Y.S., Li J.L. and Li Y.Q., Expression of vesicular glutamate transporters in peripheral vestibular structures and vestibular nuclear complex of rat. , Neuroscience. 2011, 173: 179-189. |
| Researcher : Zhang H |
| Project Title: | Structural studies of influenza proteins NEP and M1: implications for rational drug design |
| Investigator(s): | Zhang H, Hao Q |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2010 |
| Completion Date: | 02/2011 |
| Project Title: | Interaction studies of CD38 with CD4 and anti-CD38 antibodies |
| Investigator(s): | Zhang H, Hao Q |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2010 |
| Project Title: | Structural study of New Delhi metallo-beta-lactamase for rational inhibitor design |
| Investigator(s): | Zhang H, Hao Q |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2011 |
| List of Research Outputs |
| Zhang H. and Hao Q., Crystal structure of NDM-1 reveals a common β-lactam hydrolysis mechanism, The FASEB Journal. 2011, 25: 2574-2582. |
| Zhang H., Graeff R., Chen Z., Zhang L., Lee H.C. and Hao Q., Dynamic conformations of the CD38-mediated NAD cyclization captured in a single crystal, J Mol Biol. 2011, 405(4): 1070-8. |
| Zhao Y., Zhang H., Lam M.C., Hao Q. and Lee H.C., Cytosolic Cd38 Forms Intact Disulfides And Is Active In Elevating Intracellular Cyclic Adp-ribose., Journal of Biological Chemistry . 2011, 286: 22170-22177. |
| Zhou B., Chen Q., Mallis R., Zhang H., Liu J., Reinherz E.L. and Wang J., A conserved hydrophobic patch on V? domains revealed by TCR? chain crystal structures: implications for pre-TCR dimerization, Frontiers in Immunology. 2011, 2. |
| Researcher : Zhao Y |
| Project Title: | Characteristics and potential regulatory mechanisms of a cytosolic CD38 |
| Investigator(s): | Zhao Y, Lee HC |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2011 |
| List of Research Outputs |
| Zhao Y., Zhang H., Lam M.C., Hao Q. and Lee H.C., Cytosolic Cd38 Forms Intact Disulfides And Is Active In Elevating Intracellular Cyclic Adp-ribose., Journal of Biological Chemistry . 2011, 286: 22170-22177. |