Dept of Medicine

DEPT OF MEDICINE

Researcher : Au KW

List of Research Outputs

Ho J.C.Y., Zhou T., Lai K.W.H., Huang Y., Chan Y.C., Li X., Wong L.Y. .N., Li Y., Au K.W., Guo D., Xu J., Siu D.C.W., Pei D., Tse H.F. and Esteban M.A., Generation of induced pluripotent stem cell lines from 3 distinct laminopathies bearing heterogeneous mutations in lamin A/C., Aging (Albany NY). 2011, 3(4): 380-90.

Li M., Ho J.C.Y., Lai K.W.H., Au K.W., Xu A., Cheung B.M.Y., Lam K.S.L. and Tse H.F., Hypoadiponectinemia and its Impact on circulating endothelial progenitor cells in patients with type 2 diabetes - adiponectin and endothelial progenitor cells, Diabetes/Metab Res Rev. 2010, 27: 185-94.

Li M., Ho J.C.Y., Lai K.W.H., Au K.W., Xu A., Cheung B.M.Y., Lam K.S.L. and Tse H.F., The decrement in circulating endothelial progenitor cells (EPCs) in type 2 diabetes is independent of the severity of the hypoadiponectemia, Diabetes Metab Res Rev. 2011, 27(2): 185-194.

Liao S., Liu Y., Siu D.C.W., Zhang Y., Lai K.W.H., Au K.W., Lee Y.K., Li R.A. and Tse H.F., Proarrhythmic risk of embryonic stem cell-derived cardiomyocyte transplantation in infarcted myocardium, Heart Rhythm. 2010, 7(12): 1852-9.

Ng K.M., Chan Y.C., Lee Y.K., Lai W.H., Au K.W., Fung M.L., Siu D.C.W., Li R.A. and Tse H.F., Cobalt Chloride Pretreatment Promotes Cardiac Differentiation of Human Embryonic Stem Cells under atmospheric oxygen level. x, Cell Reprogramming. In press.. 2011.

Researcher : Au WS

List of Research Outputs

Tang S.C.W., Lin M., Tam S., Au W.S., Ma M.K., Yap D.Y., Ho Y.W. and Lai K.N., Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-labeled pilot study, Nephrology Dialysis Transplantation. 2011.

Researcher : Au WY

List of Research Outputs

Au W.Y., Ngai C.W., Chan W.M., Leung R.Y.Y. and Chan S.C., Hemolysis and methemoglobinemia due to hepatitis E virus infection in patient with G6PD deficiency (Letter to the Editor) , Annals of Hematology. 2011, 90(10): 1237-1238.

Chan K.S., Au W.Y., Wong C.Y., Liang R.H.S., Leung A.Y.H., Kwong Y.L. and Khong P.L., Metabolic activity measured by F-18 FDG PET in NK-cell lymphoma compared to aggressive B- and T-cell lymphomas, Clinical Nuclear Medicine . 2010, 35: 571-575.

Chan T.S., Au W.Y., Lam K., Lam Y.F., So J.C.C., Leung A.Y.H., Tse E.W.C., Lie A.K.W. and Kwong Y.L., Donor cell leukaemia after allogeneic haematopoietic SCT followed by prolonged thalidomide maintenance for multiple myeloma, Bone Marrow Transplant. 2011, [Epub ahead of print].

Chan V.W., Song K., Mang O., Ip D.K.M. and Au W.Y., Incidence of plasma cell myeloma in ethnic Chinese in British Columbia, a 30-year survey from 1975-2004 (Abstract and poster presentation), 52rd ASH Annual Meeting and Exposition, 4-7 December 2010, Orlando. Orlando, American Society of Hematology, 2010.

Cheung J.S., Au W.Y., Ha S.Y., Kim D., Jensen J.H., Zhou Y., Cheung M.M.H., Wu Y., Guo H., Khong P.L., Brown T.R., Brittenham G.M. and Wu E.X., Reduced transverse relaxation rate (RRS) for improved sensitivity in monitoring myocardial iron in thalassaemia, Journal of Magnetic Resonance Imaging . 2011, 33: 1510-1516.

Dong G., Chanudet E., Zeng N., Appert A., Chen W.Y.W., Au W.Y., Hamoudi R., Watkins A.J., Ye H., Liu H., Gao Z., Chuang S.S., Srivastava G. and Du M.Q., A20, ABIN-1/2 and CARD11 mutations and their prognostic value in gastrointestinal diffuse large B-cell lymphoma, Clin Cancer Res. 2011, [Epub ahead of print].

Gill H., Chim J.C.S., Au W.Y., Loong F., Tse E.W.C., Leung A.Y.H. and Kwong Y.L., Non-gastric marginal zone B cell lymphoma: clinicopathologic features and treatment results, Ann Hematol. 2011, [Epub ahead of print].

Iqbal J., Weisenburger D.D., Chowdhury A., Tsai M.Y., Srivastava G., Greiner T.C., Kucuk C., Deffenbacher K., Vose J., Smith L., Au W.Y., Nakamura S., Seto M., Delabie J., Berger F., Loong F., Ko Y.H., Sng I., Liu X., Loughran T.P., Armitage J., Chan W.C. and International Peripheral T-cell Lymphoma Project , Natural killer cell lymphoma shares strikingly similar molecular features with a group of non-hepatosplenic γδ T-cell lymphoma and is highly sensitive to a novel aurora kinase A inhibitor in vitro, Leukemia. 2010, 25(2): 348-58.

Jima D.D., Zhang J., Jacobs C.J., Richards K.L., Dunphy C.H., Choi W.L., Au W.Y., Srivastava G., Czader M.B., Rizzieri D.A., Lagoo A.S., Lugar P.L., Mann K.P., Flowers C.R., Bernal-Mizrachi L., Naresh K.N., Evens A.M., Gordon L.I., Luftig M.A., Friedman D.R., Weinberg J.B., Thompson M.A., Gill J.I., Liu Q., How T., Grubor V., Gao Y., Patel A., Wu H., Zhu J., Blobe G.C., Lipsky P.E., Chadburn A. and Dave S.S., Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs, Blood. 2010, 116: e118-e127.

Lam B., Wong M.K.Y., Lu K.H., Au W.Y., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Liang R.H.S., Lam W.K., Ip M.S.M. and Lie A.K.W., Effects of Azithromycin in bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation – a randomized double-blinded placebo-controlled study, Bone Marrow Transplantation. 2011, Epub ahead of print.

Lam C.L.D., Lam B., Wong M.K.Y., Lu K.H., Au W.Y., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Liang R.H.S., Lam W.K., Ip M.S.M. and Lie A.K.W., Effects of Azithromycin in bronchiolitis obliterans syndrome after hematopoietic SCT-a randomized double-blinded placebo-controlled study, Bone marrow transplantation. 2011, Epub ahead of print.

Zeng N., Dong G., Bi Y., Chanudet E., Huang Y., Appert A., Chen W.Y.W., Au W.Y., Hamoudi R.A., Watkins A.J., Ye H., Liu H., Zhu X., Zou L., Chen R., Gao Z., Chuang S.S., Srivastava G. and Du M.Q., Genetic abnormalities of NF-kB regulators in ocular adnexal MALT lymphoma and gastrointestinal DLBCL, The 3rd UK & Ireland NF-kB meeting. 2011.

Researcher : Au Yeung KL

List of Research Outputs

Lee E.Y.P., Au Yeung K.L., Anthony M., Loong F. and Khong P.L., Utility of 18F-FDG PET/CT in identifying terminal ileal myeloid sarcoma in an asymptomatic patient., Am J Hematol.. 2011.

Researcher : Bow CHY

List of Research Outputs

Bow C.H.Y., Leung E., Cheung C.L., Xiao S., Loong C., Soong S.S., Tan K.C.B., Luckey M.M., Cauley J.A., Fujiwara S. and Kung A.W.C., Ethnic Difference of Clinical Vertebral Fracture Risk, 12th Regional Osteoporosis Conference, Hong Kong. 2011.

Bow C.H.Y., Cheung E., Cheung C.L., Xiao S., Loong C., Soong S.S., Tan K.C.B., Luckey M.M., Cauley J.A., Fujiwara S. and Kung A.W.C., Ethnic difference of clinical vertebral fracture risk, Osteoporosis International. 2011.

CHN L.O.O.N.G., Bow C.H.Y., Yeung S.C., Tan K.C.B. and Kung A.W.C., Bone Mineral Density in Patients with Spine Fracture Treated with Alendronate Sodium and Strontium Ranelate, 12th Regional Osteoporosis Conference, Hong Kong. 2011.

Li H.Y., Cheung C.L., Xiao S., Lau K.S., Gao Y., Bow C.H.Y., Huang Q.Y., Sham P.C. and Kung A.W.C., Identification Of Qtl Genes For Bmd Variation Using Both Linkage And Gene-based Association Approaches., Human Genetics. 2011.

Xiao S., Gao Y., Cheung C.L., Bow C.H.Y., Lau K.S., Sham P.C., Tan K.C.B. and Kung A.W.C., Association of Cdx1 Binding Site of Periostin Gene with Bone Mineral Density and Vertebral Fracture Risk, The 3rd Joint Meeting of the European Calcified Tissue Society and the International Bone and Mineral Society, 7-11 MAY, Athens, Greece. Athens, Greece, 2011, 7-11 MAY.

Researcher : But DYK

List of Research Outputs

Fung J.Y.Y., Lai C.L., But D.Y.K., Hsu A.S.J., Seto W.K., Cheng C.T.K., Wong D.K.H. and Yuen R.M.F., Reduction of liver stiffness following resolution of acute flares of chronic hepatitis B., Hepatol Int . 2010, 4(4): 716-22.

Researcher : Chan CK

List of Research Outputs

Hung I.F.N., Leung A.Y.M., Chu D.W.S., Leung Y.P., Cheung T..., Chan C.K., Lam C.L.K., Liu S...H..., Chu C...M..., Ho P.L., Chan S.S.C., Lam T.H., Liang R.H.S. and Yuen K.Y., Prevention of acute myocardial infarction and stroke among elderly persons by dual pneumococcal and influenza vaccination: a prospective cohort study, Clinical Infectious Diseases. 2010, 51(9): 1007-1016.

Researcher : Chan DTM

Project Title:	The role of anti-dsDNA antibodies in mediating fibrotic processes in human proximal tubular epithelial cells
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2008
Completion Date:	10/2010

Project Title:	Serum immunoglobulin levels and resident renal cell-binding in patients with severe lupus nephritis
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2009
Completion Date:	10/2011

Project Title:	The role of annexin II in the pathogenesis of lupus nephritis
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010

Project Title:	Provision of HBVDNA assays for immunosuppressed HBsAg-positive kidney transplant recipients and patients with kidney diseases
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	07/2010

Project Title:	43rd Annual Meeting and Scientific Exposition of the American Society of Nephrology Comparison of Mycophenolate Mofetil and Rapamycin on Inflammatory and Fibrotic Mediators in NZB/W Mice with Active Nephritis
Investigator(s):	Chan DTM
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	11/2010
Completion Date:	11/2010

Project Title:	Characterization of renal proximal tubular epithelial cell antigens that mediate anti-dsDNA antibody binding and internalization, and their pathogenic role in lupus nephritis
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2011

Project Title:	The role of fibronectin in the pathogenesis of lupus nephritis
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	03/2011

List of Research Outputs

Chan D.T.M., Zhang C., Chau K.M. and Yung S.S.Y., Comparison of mycophenolate mofetil and rapamycin on inflammatory and fibrotic mediators in NZB/W mice with active disease, Journal of the American Society of Nephrology. 2010, 21: 753A.

Chan D.T.M., Zhang C., Chau K.M. and Yung S.S.Y., Effects of mycophenolate mofetil and rapamycin on inflammatory and fibrotic mediators in NZB/W mice with active nephritis, World Congress of Nephrology 2011.

Chan D.T.M., Initial treatment for lupus nephritis - MMR or CTX?, Asian Pacific League of Arthritis and Rheumatism (APLAR) Congress, 11-15 July, Hong Kong, . 2010.

Chan D.T.M., Lupus nephritis - Recent findings and implications on long-term renal outcome, Ten Topics in Rheumatology Conference, 20-22 August Singapore. 2010.

Chan D.T.M., Noval targarted therapies and biomarkers in lupus nepthritis, Asian Pacific League of Arthritis and Rheumatism (APLAR) Congress, 11-15 July, Hong Kong. 2010.

Cheung C.Y., Lam M.F., Lee K.C., Chan G.S.W., Chan K.W., Chau K.F., Li C.S., Chan D.T.M. and Lai K.N., Renal cell carcinoma of native kidney in Chinese renal transplant recipients: a report of 12 cases and a review of the literature, International Urology and Nephrology. 2011, 43(3): 675-80.

Ip K.M., Yung P.M., Chan D.T.M. and Wong A.S.T., Hepatocyte growth factor modulates adhesion of ovarian cancer cells to the peritoneum mesothelium through p70 S6 kinase, 102th Annual Meeting of the American Association for Cancer Research, Orlando, FL (Abstract No. 1527). 2011.

Ma M.K.M., Yung S.S.Y., Yim A.S.Y., Ng K.F., Tang C.S.O., Lui S.L. and Chan D.T.M., Low- versus conventional-level of glucose peritoneal dialysis regimes - comparison of inflammatory and fibrotic mediators in peritoneal dialysate, World Congress of Nephrology 2011.

Tan K.C.B., Wang Y., Shiu S.W.M., Wong Y., Yung S.S.Y. and Chan D.T.M., Adenosine triphosphate binding cassette transporter G1-mediated cholesterol efflux to serum is impaired in type 2 diabetes mellitus, American Diabetes Association 71st Scientific Sessions, San Diego, USA. San Diego, USA, 2011.

Yap D.Y., Chu F.S.K., Chu S.S.M., Tam P.C., Tam S., Chan D.T.M., Lai K.N. and Tang S.C.W., CT angiography versus conventional digital angiography in preoperative assessment for Chinese living kidney donors, Journal of Nephrology. 2010, 23(6): 711-6.

Yap D.Y., Ma M.K., Lai A.S., Chan S.Y., Seto W.K., Lam M.F., Chan D.T.M. and Lai K.N., Superior mesenteric artery syndrome complicating dialysis patients with peritoneal failure-report of 3 cases, Clinical Nephrology. 2011, 75 Suppl 1: 37-41.

Yap D.Y., Tso W.K., Chu F.S., Chan D.T.M., Lai K.N. and Tang S.C.W., Transhepatic placement of hemodialysis catheter : a solution for vascular access exhaustion, Nephrology. 2010, 15(6): 661-2.

Yap D.Y.H., Tang C.S.O., Yung S.S.Y., Choy C.B.Y., Yuen R.M.F. and Chan D.T.M., Long-term outcome of renal transplant recipients with chronic hepatitis B infection - impact of antiviral treatments, Transplantation. 2010, 90(3): 325-330.

Yip T.P.S., Tse K.C., Ng F.S.K., Hung I.F.N., Lam M.F., Tang S.C.W., Lui S.L., Lai K.N., Chan D.T.M. and Lo W.K., Clinical course and outcomes of single-organism Enterococcus peritonitis in dialysis patients, Peritoneal Dialysis International. 2011, 31.

Yung S.S.Y., Cheung K.F., Zhang Q. and Chan D.T.M., Anti-dsDNA antibodies bind to mesangial annexin II in lupus nephritis. 2010 Nov;21(11):1912-27., Journal of American Society of Nephrology. 2010, 21: 1912-17.

Yung S.S.Y., Cheung K.F., Zhang Q. and Chan D.T.M., Anti-dsDNA antibodies from patients with lupus nephritis bind to annexin II on human mesangial cells, Journal of the American Society of Nephrology. 2010, 21: 755A.

Researcher : Chan FHW

List of Research Outputs

Lam T.P., Chow R.W.M., Lam K.F., Lennox I.M., Chan F.H.W. and Tsoi S.L.T., Evaluation of the learning outcomes of a year-long postgraduate training course in community geriatrics for primary care doctors, Archives of Gerontology and Geriatrics. 2011, 52: 350-6.

Researcher : Chan HHL

Project Title:	The role of epidermal cooling in improving the outcome of laser therapy in the treatment of Nevus of Ota
Investigator(s):	Chan HHL, Lam LK
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2000

Project Title:	The use of vascular lasers in the treatment of port wine stain in chinese
Investigator(s):	Chan HHL, Wei WI
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	11/2001

List of Research Outputs

Yiu K.H., Yeung C.K., Chan K.H.T., Wong R.M.Y., Tam S., Lam K.F., Yan G., Yue W., Chan H.H.L. and Tse H.F., Increased arterial stiffness in patients with psoriasis is associated with active systemic inflammation, British Journal of Dermatology. British Association of Dermatologists, 2011, 164: 514-520.

Researcher : Chan JCK

Project Title:	Application of the APACHE II and III prognostic scoring methods in the 14-bed Intensive Care Unit at Queen Mary Hospital
Investigator(s):	Chan JCK, Lam WK
Department:	Medicine
Source(s) of Funding:	Health Services Research Fund - Full Grants
Start Date:	07/1995

Researcher : Chan KH

Project Title:	Clinical outcome of multiple sclerosis in Hong Kong Chinese
Investigator(s):	Chan KH
Department:	Medicine
Source(s) of Funding:	Bayer Pharmaceuticals Ltd. - General Award
Start Date:	01/2008

Project Title:	Study of clinical and immunological characteristics of local multiple sclerosis patients
Investigator(s):	Chan KH, Ho SL
Department:	Medicine
Source(s) of Funding:	Bayer Pharmaceuticals Ltd. - General Award
Start Date:	03/2008

Project Title:	Study of pathophysiological effect of anti-aquaporin-4 autoantibodies in neuromyelitis optica by passive transfer into mice
Investigator(s):	Chan KH, Ho SL, Ho WL
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2009

Project Title:	Study of potential neuroprotective role of adiponectin and APPL1 in beta-amyloid neurotoxicity
Investigator(s):	Chan KH, Lam KSL, Xu A, Ho SL, Ho WL
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2010

List of Research Outputs

Chan K.H., Kwan S.C., Ho W.L., Ho W.M. and Ramsden D.B., Aquaporin-4 autoantibodies in neuromyelitis optica spectrum disorders: comparison between tissue-based and cell-based indirect immunofluorescence assays, 15th Research Postgraduate Symposium, LKS Faculty of Medicine, the University of Hong Kong. 2010.

Chan K.H., Kwan S.C., Ho W.L., Ho W.M., Chu A.C.Y. and Ramsden D.B., Aquaporin-4 autoantibodies in neuromyelitis optica spectrum disorders: comparison between tissue-based and cell-based indirect immunofluorescence assays, Journal of Neuroinflammation. 2010, 7(1): 50.

Chan K.H., Kwan S.C., Ho W.L., Ho S.L., Chui W.H., Chu A.C.Y., Ho W.M., Zhang W.Y. and Kung M.H.W., Aquaporin-4 water channel expression by thymoma of patients with and without myasthenia gravis, Journal of Neuroimmunology. 2010, 227: 178-184.

Chan K.H., Autoantibodies in Neurological Disorders: Neuronal and Muscle Autoantibodies in Paraneoplastic Neurological Disorders and Autoimmune Myasthenia Gravis. Germany, LAP Lambert Academic Publishing AG & Co. KG, 2010.

Chan K.H., Tse C. .T., Chung C.P., Lee R., Kwan S.C., Ho W.L. and Ho W.M., Brain Involvement In Neuromyelitis Optica Spectrum Disorders, Archives of Neurology. 2011, 68(11): 1432-1439.

Chan K.H., Central Nervous System Inflammatory Demyelinating Disorders in the Hong Kong Chinese, Annual Scientific Meeting of the Hong Kong Neurological Society, Hong Kong (abstract published in Hong Kong Medical Journal). 2010, 16: 24.

Chan K.H., Central nervous system inflammatory demyelinating disorders of Hong Kong Chinese, Annual Meeting of Taiwan Neurological Society 2011. Bulletin, Taiwan Neurological Society. 2011, 36: 23.

Chan K.H., Yeung S.C., Yao T., Ip M.S.M., Cheung A.H.K., Chan M.M.W. and Mak J.C.W., Elevated Plasma Adiponectin Levels In Patients With Chronic Obstructive Pulmonary Disease, Internatioanl Journal Of Tuberculosis And Lung Disease. 2010, 14: 1193-1200.

Chan K.H., Hong Kong Chinese Multiple Sclerosis Patients Develop Severe Disability Earlier Than Caucasian Multiple Sclerosis Patients, Press Conference organized by the Hong Kong Neuromuscular Association. 2011.

Chan K.H., Long-term treatment of relapsing remitting multiple sclerosis, Journal of The Society of Physicians of Hong Kong. 2010, 2 (5): 58-60.

Chan K.H., Multiple Sclerosis And Neuromyelitis Optica Spectrum Disorders, Rotary Club of Kowloon. 2010.

Chan K.H., Kwan S.C., Zhang R., Ho W.L. and Ho W.M., Passive transfer of IgG from aquaporin-4 autoantibodies seropositive neuromyelitis optica patients to mice cause spinal cord aquaporin-4 loss without myelitis, 63rd American Academy of Neurology Annual Meeting, Neurology. 2011, 76 (Supplement 4): A537-538.

Chan K.H., Update On Management Of Autoimmune Myasthenia Gravis, Invited Talk by the Myasthenia Gravis Group of the Hong Kong Neuromuscular Association. 2010.

Chan K.H., Update on treatment of autoimmune myasthenia gravis, Invited Lecture to the Public - Hong Kong Neuromuscular Association. 2010.

Ho W.L., Ho W.M., Liu H., So H.F., Chan K.H., Ramsden D.B. and Ho S.L., Functional studies of neuronal mitochondrial uncoupling proteins: implication in the pathology of Parkinson’s disease, The Hong Kong Neurological Society - Annual Scientific Meeting 2010; Kowloon Shangri-La Hotel, Hong Kong; 2010.. 2010.

Ho W.L., Ho W.M., So H.F., Liu H., Chan K.H., Ramsden D.B. and Ho S.L., Manipulation of mitochondria functions via uncoupling proteins as novel strategy against energy deficiency and neurodegeneration, Croucher Advanced Study Institute on Mitochondrial Stress in Diabetes and Aging, 29 April, 2011, organized by the Croucher Foundation; HBHA, University of Hong Kong.. 2011.

Ho W.L., Ho W.M., So H.F., Liu H., Chan K.H., Ramsden D.B. and Ho S.L., Potential role of mitochondrial uncoupling protein-4 (UCP4) in energy supply during neuronal differentiation , 16th Medical Research Conference 2011, University of Hong Kong. 2011, 17(1): suppl 1;: 31.

Ho W.L., Ho W.M., Zhang W., Yiu C.W., Liu H., Chan K.H., Ramsden D.B. and Ho S.L., Role of mitochondrial uncoupling protein-4 (UCP4) in energy supply during neuronal differentiation, EMBO Meeting 2010, Barcelona, Spain. 2010.

Ho W.M., Ho W.L., Zhang W., Liu H., Kwok H.H., Yiu C.W., Chan K.H., Kung M.H.W., Ramsden D.B. and Ho S.L., Activation of c-Rel mediates neuroprotection via mitochondrial uncoupling protein-4 under NF-kB pathways, EMBO Meeting 2010, Barcelona, Spain (4-7 Sept, 2010). 2010.

Lau K.W., Chan K.H., Yeung S.C., Ip M.S.M. and Mak J.C.W., Effects of cigarette smoke exposure on serum 5-HT levels in rats, American Journal of Respiratory and Critical Care Medicine. 2011, 183: A2454.

Leung G.K.K., Chan K.H. and Hung K.N., Growing skull fracture in an adult nine years after blunt head trauma, Journal of Clinical Neuroscience. 2011, 18: 855-857.

Pang S.Y.Y., Lee C.N., Tsoi T.H., Yip K.K., Chan K.H., Kung M.H.W. and Ho S.L., Transient axonal glycoprotein-1 (TAG-1) polymorphism and its correlation with clinical features and prognosis in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), 63rd American Academy of Neurology Annual Meeting 2011, Honlolulu,Hawaii; Neurology. 2011, 76 (Suppl 4): A570.

Qian W., Chan Q., Mak H.K.F., Zhang Z., Anthony M., Yau K.K.W., Khong P.L., Chan K.H. and Kim M., Quantitative assessment of the cervical spinal cord damage in neuromyelitis optica using diffusion tensor imaging at 3 Tesla, Journal of Magnetic Resonance Imaging. 2011, 33: 1312-1320.

Tse C.T., Chung C.P., Tse M.M.Y., Ho S.L., Cheung K.S., Kwan S.C., Ho W.L., Ho W.M. and Chan K.H., Cerebral involvement in neuromyelitis optica spectrum disorders among Hong Kong Chinese, 16th Medical Research Conference, Department of Medicine, The University of Hong Kong, 2011. Hong Kong Medical Journal. 2011, 17 (Supplement 1): 55.

Tse C.T., Lee R., Kwan S.C., Ho W.L., Ho W.M. and Chan K.H., Cerebral involvement in neuromyelitis optica spectrum disorders with aquaporin-4 autoimmunity, Sixth International Symposium On Healthy Aging. 2011.

Zhou L., Chu L.W., Kwan S.C., Lam K.S.L., Ho W.L., Ho W.M. and Chan K.H., Plasma amyloid beta peptides and oligomers antibodies in Alzheimer's disease, 16th Medical Research Conference, Department of Medicine, The University of Hong Kong, 2011. Hong Kong Medical Journal . 2011, 17 (Supplement 1): 69.

Zhou L., Chu L.W., Kwan S.C., Lam K.S.L., Ho W.L., Ho W.M. and Chan K.H., Plasma amyloid beta peptides and oligomers levels in Alzheimer's disease, 16th Medical Research Conference, Department of Medicine, The University of Hong Kong, 2011. Hong Kong Medical Journal. 2011, 17 (Supplement 1): 69.

Zhou L., Chu L.W., Kwan S.C., Lam K.S.L., Ho W.L., Ho W.M. and Chan K.H., Plasma beta-amyloid peptides and serum associated beta-amyloid autoantibodies in patients with Alzheimer's disease, Alzheimer's Disease Conference 2011: From Public Health, Basci And Clinical Sciences To Therapeutic Insights. 2011.

Zhou L., Chu L.W., Kwan S.C., Lam K.S.L., Ho W.L., Ho W.M. and Chan K.H., Plasma b-amyloid Peptides And Serum Associated b-amyloid Autoantibodies In Alzheimer's Disease, Sixth International Symposium On Healthy Aging. 2011.

Researcher : Chan KH

List of Research Outputs

Chan K.H., Tse C. .T., Chung C.P., Lee R., Kwan S.C., Ho W.L. and Ho W.M., Brain Involvement In Neuromyelitis Optica Spectrum Disorders, Archives of Neurology. 2011, 68(11): 1432-1439.

Chan K.H., Long-term treatment of relapsing remitting multiple sclerosis, Journal of The Society of Physicians of Hong Kong. 2010, 2 (5): 58-60.

Chan K.H., Multiple Sclerosis And Neuromyelitis Optica Spectrum Disorders, Rotary Club of Kowloon. 2010.

Chan K.H., Update On Management Of Autoimmune Myasthenia Gravis, Invited Talk by the Myasthenia Gravis Group of the Hong Kong Neuromuscular Association. 2010.

Chan K.H., Update on treatment of autoimmune myasthenia gravis, Invited Lecture to the Public - Hong Kong Neuromuscular Association. 2010.

Leung G.K.K., Chan K.H. and Hung K.N., Growing skull fracture in an adult nine years after blunt head trauma, Journal of Clinical Neuroscience. 2011, 18: 855-857.

Researcher : Chan KHT

List of Research Outputs

Chan Y.H., Lam T.H., Lau G.K.K., Yiu K.H., Siu D.C.W., Li L.S.W., Chan K.H.T., Tam S., Lau C.P. and Tse H.F., Dietary intake of phytoestrogen is associated with increased circulating endothelial progenitor cells in patients with cardiovascular disease, European Journal of Cardiovascular Prevention and Rehabilitation. 2011, 18(3): 360-368.

Yiu K.H., Yeung C.K., Chan K.H.T., Wong R.M.Y., Tam S., Lam K.F., Yan G., Yue W., Chan H.H.L. and Tse H.F., Increased arterial stiffness in patients with psoriasis is associated with active systemic inflammation, British Journal of Dermatology. British Association of Dermatologists, 2011, 164: 514-520.

Researcher : Chan MMW

Project Title:	A surveillance program of tuberculosis in old age homes in Hong Kong
Investigator(s):	Chan MMW, Chu LW, Lam WK
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	11/2001

Project Title:	A surveillance program of tuberculosis in old age homes in Hong Kong
Investigator(s):	Chan MMW, Chu LW, Lam WK
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2004

List of Research Outputs

Carlsten C., Dimich-Ward H., Ferguson A., Becker A., Dybuncio A. and Chan M.M.W., Airway hyperresponsiveness to methacholine in 7-year-old children: sensitivity and specificity for pediatric allergist-diagnosed asthma., Pediatr Pulmonol. 2011, 46(2): 175-8.

Carlsten C., Ferguson A., Dimich-Ward H., Chan H., DyBuncio A., Rousseau R., Becker A. and Chan M.M.W., Association between endotoxin and mite allergen exposure with asthma and specific sensitization at age 7 in high-risk children, Pediatr Allergy Immunol. 2011, 22(3): 320-6.

Carlsten C., Brauer M., Dimich-Ward H., Dybuncio A., Becker A.B. and Chan M.M.W., Combined exposure to dog and indoor pollution: incident asthma in a high-risk birth cohort. , Eur Respir J. 324-30, 2011, 37(2).

Carlsten C., Dybuncio A., Becker A., Chan M.M.W. and Brauer M., GSTP1 polymorphism modifies risk for incident asthma associated with nitrogen dioxide in a high-risk birth cohort., Occup Environ Med.. 2011, 68(4): 308.

Carlsten C., Dybuncio A., Becker A., Chan M.M.W. and Brauer M., Traffic-related air pollution and incident asthma in a high-risk birth cohort., Occup Environ Med. 2011, 68(4): 291-5.

Chan K.H., Yeung S.C., Yao T., Ip M.S.M., Cheung A.H.K., Chan M.M.W. and Mak J.C.W., Elevated Plasma Adiponectin Levels In Patients With Chronic Obstructive Pulmonary Disease, Internatioanl Journal Of Tuberculosis And Lung Disease. 2010, 14: 1193-1200.

Chan M.M.W., Anthonisen N.R., Becklake M.R., Bowie D., Sonia Buist A., Dimich-Ward H., Ernst P., Sears M.R., Siersted H.R., Sweet L., Van Til L. and Manfreda J., Geographical variations in the prevalence of atopic sensitization in six study sites across Canada., Allergy. 1404-13, 2010, 65(11).

Dimich-Ward H., Beking K.H., Dybuncio A., Bartlett K.H., Karlen B.J., Chow Y. and Chan M.M.W., Respiratory health of two cohorts of terminal grain elevator workers studied 30 years apart., Am J Ind Med. . 263-8, 2011, 54(4).

Lo A.I.L., Huang Y., Lam S.Y., Cheung A.H.K., Au R., Leung C.C., Lam W.K., Ip M.S.M., Chan M.M.W. and Lam B., Early detection of central airway lung cancer in smokers with silicosis, International Journal of Tuberculosis and Lung Disease. 2011, 15(4): 523-527.

Plaisant A., Pierard C., Beyers N., Chan M.M.W. and Enarson D.A., Authorship affiliations in original articles submitted to the International Journal of Tuberculosis and Lung Disease., Int J Tuberc Lung Dis. 2010, 14(12): 1650-2.

Researcher : Chan SY

List of Research Outputs

Chim J.C.S., Wong K.Y., Leung C.Y., Chung L.P., Hui P.K., Chan S.Y. and Yu L., Epigenetic inactivation of the hsa-miR-203 in haematological malignancies, J Cell Mol Med. 2011, [Epub ahead of print].

Chu L.W., Luk J.K.H., Hui E., Chiu P.K.C., Chan S.Y., Kwan S.M., Kwok T., Lee D. and Woo J., Advance directive and end-of-life care preferences among Chinese nursing home residents in Hong Kong, J Am Med Dir Assoc. . 2011, 12(2): 143-52.

Researcher : Chan SY

List of Research Outputs

Researcher : Chan VNY

Project Title:	Hepatitis B virus array for genotyping and mutation detection
Investigator(s):	Chan VNY, Lai CL, Chan K, Yuen RMF
Department:	Medicine
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	11/2006

List of Research Outputs

Farrell J.J., Sherva R.M., Chen Z.Y., Luo H.Y., Chu B.F., Ha S.Y., Li C.K., Lee A.C., Li R.C., Li C.K., Yuen H.L., So J.C.C., Ma E.S.K., Chan L.C., Chan V.N.Y., Sebastiani P., Farrer L.A., Baldwin C.T., Steinberg M.H. and Chui D.H., A 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression, Blood. 2011, 117(18): 4935-45.

Li T.K.T., Leung K.Y., Lam Y.H., Tang M.H.Y. and Chan V.N.Y., Haemoglobin level, proportion of haemoglobin Bart's and haemoglobin Portland in fetuses affected by homozygous α⁰-thalassemia from 12 to 40 weeks' gestation, Prenatal Diagnosis. 2010, 30(12-13): 1126-30.

Researcher : Chan VSF

Project Title:	Development of a humanized mouse systemic lupus erythematosus model for studying disease pathogenesis and evaluation of therapeutic treatment efficacy
Investigator(s):	Chan VSF
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2011

List of Research Outputs

Dejnirattisai W., Webb A.I., Chan V.S.F., Jumnainsong A., Davidson A., Mongkolsapaya J. and Screaton G., Lectin Switching During Dengue Virus Infection, Journal of Infectious Diseases. 2011, 203: 1775-1783.

Khoo U.S., Ching J.C.Y., Chan Y.K., Xu M., So K.M., Lai S.T., Chu C.M., Yam L., Wong T.Y., Chung P.H., Chan V.S.F., Tam P.K.H., Yip S.P., Lin C.L., Sham P.C., Leung G.M. and Peiris J.S.M., The CD209 (DC-SIGN) -336A>G and MxA -123C>A promoter polymorphisms in Severe Acute Respiratory Syndrome Coronavirus infection in Hong Kong Chinese, Health Research Symposium 2010: “Improving health and recognising excellence, Hong Kong. 2010.

Researcher : Chan WK

List of Research Outputs

Jin O., Kavikondala S., Sun L.Y., Gu J.R., Fu R., Mok T.M.Y., Chan W.K., Yeung J.S.L., Nie Y. and Lau W.C.S., Abnormalities in circulating plasmacytoid dendritic cells in patients with systemic lupus erythematosus., Arthritis Research & Therapy. 2010, 12(4): R137.

Researcher : Chan WM

List of Research Outputs

Chan W.M., Lau L.S., Kwok K.M., Law W.L., Ho J.C.M., Chu K.M. and Poon R.T.P., A randomized, double-blind, placebo-controlled, ascending dose infusion trial of the pharmacokinetics of recombinant human gelsolin in patients with decreased natural gelsolin levels. ATS meeting 2011 , American Journal of Respiratory and Critical Care Medicine. 2011, 183: A5601.

Researcher : Chan YC

Project Title:	Promotion Of Mouse Embryonic Stem Cell Differentiation Into Cardiomyocytes Via Electrical Stimulation
Investigator(s):	Chan YC, Tse HF, Siu DCW
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	07/2009
Completion Date:	01/2011

List of Research Outputs

Chan Y.C., Tse H.F. and Siu D.C.W., A Newly-derived Small Synthetic Compound Alleviated Ventricular Fibrillation In A Pig Model With Chronic Myocardial Infarction As Revealed By Optical Mapping., 16th Medical Research Conference (15th MRC) (Hong Kong, 2011), Department of Medicine, HKU. 2011.

Chan Y.C., Tse H.F. and Siu D.C.W., A Newly-derived Small Synthetic Compound Alleviated Ventricular Fibrillation In A Pig Model With Chronic Myocardial Infarction As Revealed By Optical Mapping., Sixth International Symposium on Healthy Aging (Hong Kong, 2011), Department of Medicine, HKU . 2011.

Chan Y.C., Leung C.F.P., Yung L.M., Lau C.W., Chen Z.Y., Yao X.Q., Laher I. and Huang Y., Raloxifene improves vascular reactivity in pressurized septal coronary arteries of ovariectomized hamsters fed cholesterol diet, Pharmacological Research (under review). 2010.

Chan Y.C., Young Investigator Award (Poster Category), Sixth International Symposium on Healthy Aging – A New Golden Age, Research Centre of Heart, Brain, Hormone & Healthy Aging, HKU . 2011.

Ho J.C.Y., Zhou T., Lai K.W.H., Huang Y., Chan Y.C., Li X., Wong L.Y. .N., Li Y., Au K.W., Guo D., Xu J., Siu D.C.W., Pei D., Tse H.F. and Esteban M.A., Generation of induced pluripotent stem cell lines from 3 distinct laminopathies bearing heterogeneous mutations in lamin A/C., Aging (Albany NY). 2011, 3(4): 380-90.

Lee Y.K., Ng K.M., Lai K.W.H., Chan Y.C., Lau Y.M., Lian Q., Tse H.F. and Siu D.C.W., Calcium Homeostasis in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes., Stem Cell Reviews and Reports. 2011.

Ng K.M., Chan Y.C., Lee Y.K., Lai W.H., Au K.W., Fung M.L., Siu D.C.W., Li R.A. and Tse H.F., Cobalt Chloride Pretreatment Promotes Cardiac Differentiation of Human Embryonic Stem Cells under atmospheric oxygen level. x, Cell Reprogramming. In press.. 2011.

Ng K.M., Chan Y.C., Lee Y.K., Lai W.H., Fung M.L., Siu D.C.W., Li R.A. and Tse H.F., Cobalt chloride pre-treatment enhances the calcium handling of human embryonic stem cells-derived cardiomyocytes, Differentiation, 80:S44 Suppl. 1, 2010.

Ng K.M., Lee Y.K., Lai K.W.H., Chan Y.C., Fung M.L., Tse H.F. and Siu D.C.W., Exogenous Expression of Human apoA-I Enhances Cardiac Differentiation of Pluripotent Stem Cells., PLoS One. 2011.

Wang X.M., Li W., Fan W.X., Chan Y.C., Zhang S.Q., Guo X.P., Zhang Y., Chen S., Zhang Y.L., Schambach A., Tse H.F., Pei D.Q. and Esteban M.A., Modeling Abnormal Early Development with Induced Pluripotent Stem Cells from Aneuploid Syndromes., Human Molecular Genetics (Under Review). 2011.

Zhang J., Chan Y.C., Ho J.C.Y., Siu D.C.W., Lian Q. and Tse H.F., Proliferation of Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells via Ether à go-go 1 (hEAG1) Potassium Channel., Journal of Cellular and Molecular Medicine (Under Review). 2011.

Zhou T., Benda C., Duzinger S., Huang Y., Li X., Li Y., Guo X., Cao G., Chen S., Hao L., Chan Y.C., Ng K.M., Ho J.C.Y., Wieser M., Wu J., Redl H., Tse H.F., Grillari J., Grillari-Voglauer R., Pei D. and Esteban M.A., Generation of induced pluripotent stem cells from urine., Journal of the American Society of Nephrology. 2011.

Researcher : Chan YY

List of Research Outputs

Tang S.C.W., Chan Y.Y., Leung J.C.K., Cheng A.S., Lan H.Y. and Lai K.N., Additive Renoprotective Effects Of B2-kinin Receptor Blocker And PPAR-y Agonist In Uninephrectomized Db/db Mice [journal Impact Factor 4.602] (in Press), Lab Invest . 2011, 91(9): 1351-62.

Tang S.C.W., Chan Y.Y., Leung J.C.K., Cheng A.S., Lin M., Lan H.Y. and Lai K.N., Differential effects of advanced glycation end-products on renal tubular cell inflammation, Nephrology (Carlton, Vic). 2011, 16(4): 417-25.

Tang S.C.W., Leung V.T.M., Chan Y.Y., Wong S.S., Chu D.W., Leung J.C.K., Ho Y.W., Lai K.N., Ma L., Elbein S.C., Bowden D.W., Hicks P.J., Comeau M.E., Langefeld C.D. and Freedman B.I., The acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with nephropathy in Chinese patients with type 2 diabetes, Nephrology Dialysis Transplantation. 2010, 25(12): 3931-4.

Researcher : Chang J

List of Research Outputs

Chang J., Li Y., Huang Y., Lam K.S.L., Hoo R.L.C., Wong W.T., Cheng K.Y., Wang Y., Vanhoutte P.M.G.R. and Xu A., Adiponectin prevents diabetic premature senescence of endothelial progenitor cells and promotes endothelial repair by suppressing the p38 MAP kinase/p16INK4A signaling pathway, Diabetes. 2010, 59: 2949-59.

Researcher : Chau KF

List of Research Outputs

Cheung C.Y., Lam M.F., Lee K.C., Chan G.S.W., Chan K.W., Chau K.F., Li C.S., Chan D.T.M. and Lai K.N., Renal cell carcinoma of native kidney in Chinese renal transplant recipients: a report of 12 cases and a review of the literature, International Urology and Nephrology. 2011, 43(3): 675-80.

Researcher : Chau KM

List of Research Outputs

Chan D.T.M., Zhang C., Chau K.M. and Yung S.S.Y., Comparison of mycophenolate mofetil and rapamycin on inflammatory and fibrotic mediators in NZB/W mice with active disease, Journal of the American Society of Nephrology. 2010, 21: 753A.

Chan D.T.M., Zhang C., Chau K.M. and Yung S.S.Y., Effects of mycophenolate mofetil and rapamycin on inflammatory and fibrotic mediators in NZB/W mice with active nephritis, World Congress of Nephrology 2011.

Researcher : Che H

List of Research Outputs

Che H. and Li G., Characterization of transient receptor potential channels in human preadipocytes, Omics Meets Cell Biology, May 2011. Alpbach Congress Centrum. Alpbach, Austria. 2011, 68-108.

Che H. and Li G.R., Functional expression of transient receptor potential channels in human preadipocytes, 16th Medical Research Conference, Department of Medicine, HKU. 2011, 17(1): 32.

Researcher : Chen B

List of Research Outputs

Cheng K.Y., Lam K.S.L., Chen B., Zhu W., Wang Y. and Xu A., 銜接蛋白質APPL1和APPL2對島素敏感性和葡萄糖代謝的陰陽調控 - 從分子機制到生理作用, 2011.

Zhu W., Cheng K.Y., Chen B., Wang Y., Lam K.S.L. and Xu A., APPL2 inhibits insulin-stimulated glucose uptake through both Akt and its downstream target TBC1D1 in skeletal muscle, 16th Medical Research Conference. The University of Hong Kong, Hong Kong. . 2011.

Researcher : Chen C

List of Research Outputs

Chen C., Zhang X., Wong L.C., Chung S.K., Xu A. and Lam K.S.L., Adipose Tissue-specific Suppression Of C-jun Terminal Kinase Attenuates Obesity-related Metabolic Disorders In A Genetic Mouse Model Of Obesity And Type 2 Diabetes, ADA 2011.

Chen C., Tso A.W.K., Cheung B.M.Y., Ong K.L., Wat N.M.S., Edward D J.A.N.U.S., Xu A. and Lam K.S.L., Circulating Pigment Epithelium-Derived Factor Levels and the Risk of Hypertension in a Community-based Study., 16th Medical Research Conference, The University of Hong Kong. 2011.

Chen C., Tso A.W.K., Law S.C., Cheung B.M.Y., Ong K.L., Wat N.M.S., Janus E.D., Xu A. and Lam K.S.L., Plasma Level of Pigment Epithelium-Derived Factor Is Independently Associated with the Development of the Metabolic Syndrome in Chinese Men: A 10-Year Prospective Study. , J Clin Endocrinol Metab.. 2010, 95: 5074-81.

Ge X., Chen C., Hui X., Wang Y., Lam K.S.L. and Xu A., Fibroblast Growth Factor-21 Promotes Glucose Uptake through Activation of the serum response factor (SRF)/ Ets-like protein-1 (Elk-1) signaling cascade in Adipocytes, ADA 2011.

Michele Y.U.E.N., Wing Sun C.H.O.W., Chen C., Ting Chung P.U.N., Law S.C., Tso A.W.K., Xu A. and Lam K.S.L., . Circulating Plasma Pigment Epithelium-Derived Factor (PEDF) Levels Are Associated with Insulin Resistance in Women with Estrogen Deficiency, 71th American Diabetes Association Scientific Sessions, San Diego, CA. 2011.

Researcher : Chen JY

Project Title:	The impact of the non-formal curriculum on the developing doctor: a qualitative study of student perception of their learning experience in medical school
Investigator(s):	Chen JY, Beh SL, Patil NG
Department:	Med - Family Medicine Unit
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2009
Completion Date:	06/2011

List of Research Outputs

Chen J.Y., Salter Menzo D.J. and Chan L.C., Pen, brush and camera: outcomes-based medical humanities, In: Kevin Eva, Medical Education. 2010, 44: 1139.

Researcher : Chen W

List of Research Outputs

Ma J., Wang J., Zhang W., Zou B., Chen W., Lam S.C., Chen M., Pang R.W.C., Tan V.P.Y., Hung I.F.N., Lan H.Y., Wang Q. and Wong B.C.Y., Promoter hypermethylation and histone hypoacetylation contribute to Pancreatic-duodenal homeobox 1 (PDX1) silencing in gastric cancer., Carcinogenesis. 2010, 31(9): 1552-60.

Researcher : Chen WH

Project Title:	Enoxaparin combined with epitfibatide or abciximab versus unfractionated heparin combined with epitfibatide or abciximab in percutaneous coronary intervention: obersvations on efficacy, safety, anticoagulation profile, and level of platelet inhibition
Investigator(s):	Chen WH, Lau CP
Department:	Medicine
Source(s) of Funding:	Other Funding Scheme
Start Date:	06/2001

Project Title:	A prospective study to investigate the determinants of the quantity of embolized debris during native vessel percutaneous coronary intervention
Investigator(s):	Chen WH, Lau CP
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Project Title:	A prospective study to evaluate the relation between aspirin resistance and the incidence and magnitude of myonecrosis after percutaneous coronary intervention
Investigator(s):	Chen WH, Lau CP
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Researcher : Cheng AS

List of Research Outputs

Tang S.C.W., Chan Y.Y., Leung J.C.K., Cheng A.S., Lan H.Y. and Lai K.N., Additive Renoprotective Effects Of B2-kinin Receptor Blocker And PPAR-y Agonist In Uninephrectomized Db/db Mice [journal Impact Factor 4.602] (in Press), Lab Invest . 2011, 91(9): 1351-62.

Researcher : Cheng CTK

List of Research Outputs

Fung J.Y.Y., Lai C.L., Cheng C.T.K., Wu C.H., Wong D.K.H. and Yuen R.M.F., Mild-to-moderate elevation of alanine aminotransferase increases liver stiffness measurement by transient elastography in patients with chronic hepatitis B. [Epub 2010 Dec 14], Am J Gastroenterol . 2010, 106(3): 492-6.

Fung J.Y.Y., Lai C.L., Yuen J.C.H., Cheng C.T.K., Wu C.H., Wong D.K.H., Seto W.K., Hung I.F.N. and Yuen R.M.F., Randomized trial of lamivudine versus entecavir in entecavir-treated patients with undetectable hepatitis B virus DNA: Outcome at 2 years., Hepatology. 2011, 53(4): 1148-53.

Fung J.Y.Y., Lai C.L., But D.Y.K., Hsu A.S.J., Seto W.K., Cheng C.T.K., Wong D.K.H. and Yuen R.M.F., Reduction of liver stiffness following resolution of acute flares of chronic hepatitis B., Hepatol Int . 2010, 4(4): 716-22.

Researcher : Cheng CW

List of Research Outputs

Chow K.M., Ng L., Li H.S., Cheng C.W., Lam S.C., Chu A.C.Y., Pang R.W.C. and Poon R.T.P., Anti-tumor efficacy of recombinant human arginase in combination with chemotherapeutic agents in human hepatocellular carcinoma, AACR 102nd Annual Meeting. 2011.

Researcher : Cheng KY

Project Title:	APPL1 as a novel adaptor protein regulating insulin sensitivity and glucose homeostasis
Investigator(s):	Cheng KY, Xu A
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	08/2010

List of Research Outputs

Chang J., Li Y., Huang Y., Lam K.S.L., Hoo R.L.C., Wong W.T., Cheng K.Y., Wang Y., Vanhoutte P.M.G.R. and Xu A., Adiponectin prevents diabetic premature senescence of endothelial progenitor cells and promotes endothelial repair by suppressing the p38 MAP kinase/p16INK4A signaling pathway, Diabetes. 2010, 59: 2949-59.

Cheng K.Y., Lam K.S.L., Wang Y., Zhu W., Hoo R.L.C. and Xu A., Transgenic over-expression of APPL1 improves high-fat diet-induced insulin resistance in liver and skeletal muscle., Sixth International Symposium on Healthy Aging: " A New Golden Age”. 2011.. 2011.

Cheng K.Y., Lam K.S.L., Wang Y., Zhu W. and Xu A., Ubiquitination Is Indispensible For The Insulin-sensitizing Activity Of The Adaptor Protein Appl1. 16th Medical Research Conference. , 16th Medical Research Conference 2011. The University of Hong Kong. 2011.

Cheng K.Y., Lam K.S.L., Chen B., Zhu W., Wang Y. and Xu A., 銜接蛋白質APPL1和APPL2對島素敏感性和葡萄糖代謝的陰陽調控 - 從分子機制到生理作用, 2011.

Li F.Y.L., Cheng K.Y., Lam K.S.L., Vanhoutte P.M.G.R. and Xu A., Cross-talk Between Adipose Tissue And Vasculature: Role Of Adiponectin, Acta Physiologica. 2010.

Zhu W., Cheng K.Y., Chen B., Wang Y., Lam K.S.L. and Xu A., APPL2 inhibits insulin-stimulated glucose uptake through both Akt and its downstream target TBC1D1 in skeletal muscle, 16th Medical Research Conference. The University of Hong Kong, Hong Kong. . 2011.

Researcher : Cheng YY

Project Title:	The role of hypoxia inducible factor 1 alpha in NK/T-cell lymphoma
Investigator(s):	Cheng YY, Tse EWC
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	12/2008

Researcher : Cheung AHK

List of Research Outputs

Chan K.H., Yeung S.C., Yao T., Ip M.S.M., Cheung A.H.K., Chan M.M.W. and Mak J.C.W., Elevated Plasma Adiponectin Levels In Patients With Chronic Obstructive Pulmonary Disease, Internatioanl Journal Of Tuberculosis And Lung Disease. 2010, 14: 1193-1200.

Lam C.L.D., Fu K.H., Lui M.M.S., Yung P.M., Cheung A.H.K., Lam W.K., Wistuba I.I., Tsao G.S.W., Ip M.S.M. and Minna J.D., Expression of nicotinic acetylcholine receptor in human bronchial epithelium in relation to airflow obstruction, American Thoracic Society Annual Meeting 2011.

Lo A.I.L., Huang Y., Lam S.Y., Cheung A.H.K., Au R., Leung C.C., Lam W.K., Ip M.S.M., Chan M.M.W. and Lam B., Early detection of central airway lung cancer in smokers with silicosis, International Journal of Tuberculosis and Lung Disease. 2011, 15(4): 523-527.

Researcher : Cheung B.M.Y.

Project Title:	The effect of adrenomedullin on gene and protein expression in macrophages stimulated by tumour necrosis factor-alpha
Investigator(s):	Cheung BMY, Tang F, Lau WCS
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2010
Completion Date:	06/2011

Project Title:	Biomarkers of Obesity-related Cardiometaolic Risks in Chinese
Investigator(s):	Cheung BMY, Lam KSL, Sham PC, Xu A
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2010

Project Title:	16th World Congress on Basic and Clinical Pharmacology (WorldPharma 2010) A genetic variant in the gene encoding adrenomedullin predicts the development of dysglycaemia over 6.4 years in Chinese Relationship of plasma interleukin-6 and its genetic variants with hypertension in Hong Kong Chinese
Investigator(s):	Cheung BMY
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	07/2010
Completion Date:	07/2010

List of Research Outputs

Cheung B...M...Y..., Hung I...F...N... and Wong S...Y..., Proton Pump Inhibitors - a Sting in the Tale?, The Hong Kong Medical Daily. 2010, 15: 4-5.

Researcher : Cheung BMY

Project Title:	The effect of adrenomedullin on gene and protein expression in macrophages stimulated by tumour necrosis factor-alpha
Investigator(s):	Cheung BMY, Tang F, Lau WCS
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2010
Completion Date:	06/2011

Project Title:	Biomarkers of Obesity-related Cardiometaolic Risks in Chinese
Investigator(s):	Cheung BMY, Lam KSL, Sham PC, Xu A
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2010

Project Title:	16th World Congress on Basic and Clinical Pharmacology (WorldPharma 2010) A genetic variant in the gene encoding adrenomedullin predicts the development of dysglycaemia over 6.4 years in Chinese Relationship of plasma interleukin-6 and its genetic variants with hypertension in Hong Kong Chinese
Investigator(s):	Cheung BMY
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	07/2010
Completion Date:	07/2010

List of Research Outputs

Chen C., Tso A.W.K., Cheung B.M.Y., Ong K.L., Wat N.M.S., Edward D J.A.N.U.S., Xu A. and Lam K.S.L., Circulating Pigment Epithelium-Derived Factor Levels and the Risk of Hypertension in a Community-based Study., 16th Medical Research Conference, The University of Hong Kong. 2011.

Chen C., Tso A.W.K., Law S.C., Cheung B.M.Y., Ong K.L., Wat N.M.S., Janus E.D., Xu A. and Lam K.S.L., Plasma Level of Pigment Epithelium-Derived Factor Is Independently Associated with the Development of the Metabolic Syndrome in Chinese Men: A 10-Year Prospective Study. , J Clin Endocrinol Metab.. 2010, 95: 5074-81.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Association of a genetic variant in adrenomedullin gene with its plasma level , Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Cheung B.M.Y., Ong K.L., Jiang C.Q., Liu B., Jin Y.L., Tso A.W.K., Tam S., Wong K.S., Tomlinson B., Lin J.M., Yue X.J., Lam K.S.L., Lam T.H. and Thomas G.N., Association of a genetic variant in the apolipoprotein A5 gene with the metabolic syndrome in Chinese, Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Cheung B.M.Y., Ong K.L., Xu A., Lam T.H. and Lam K.S.L., Association of genetic variants in gene encoding lipocalin-2 with plasma alanine aminotransferase and aspartate aminotransferase, Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Cheung B.M.Y., Behind the rosiglitazone controversy, Expert Rev Clin Pharmacol. 2010.

Cheung B.M.Y., Cardiovascular risk factors in Hong Kong, Guangzhou no.12 Hospital 40th Anniversary Symposium, Guangzhou. 2010.

Cheung B.M.Y., Cardiovascular risk factors – a local landscape, 12th Hong Kong Diabetes & Cardiovascular Risk Factors – East Meets West Symposium, Hong Kong. 2010.

Cheung B.M.Y., Editorial Board, American Journal of Hypertension. 2011.

Cheung B.M.Y., Editorial Board, Cardiology Research. 2010.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Gamma-glutamyl transaminase level predicts the development of hypertension., Poster Presentation at the 23rd Scientific Meeting of the International Society of Hypertension, Vancouver. 2010.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Gamma-glutamyl transferase level predicts the development of hypertension in Hong Kong Chinese, Clin Chim Acta. 2011, 412(15-16): 1326-1331.

Cheung B.M.Y., Hypertension management update, 16th Hong Kong Medical Forum, Hong Kong. 2011.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Lam T.H. and Lam K.S.L., Increasing prevalence of hypertension and central obesity in the Hong Kong cardiovascular risk factor prevalence study, Basic & Clinical Pharmacology & Toxicology. Presented at the 10th Congress of the European Association for Clinical Pharmacology and Therapeutics, Budapest. 2011, 109 (Suppl. 1): 108.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Lam T.H. and Lam K.S.L., Increasing prevalence of hypertension in Hong Kong Cardiovascular Risk Factor Prevalence Study: Role of general and central obesity, Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Cheung B.M.Y. and Lam K.S.L., Is intensive LDL-cholesterol lowering beneficial and safe?, Lancet. 2010, 376(9753): 1622-1624.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Thomas G.N., Lam T.H. and Lam K.S.L., Mendelian randomisation analysis suggests that plasma interleukin-6 is raised in hypertension but does not cause its development, Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Cheung B.M.Y., New findings from the Hong Kong Cardiovascular Risk Factor Prevalence Study, 14th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, Hong Kong. 2010.

Cheung B.M.Y., Pharmacogenetic Algorithms to Individualise Warfarin Dosing, Hong Kong Pharmacogenetics Network Inaugural Scientific Meeting. Personalised Medicine in Practice, Hong Kong. 2011.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Plasma adrenomedullin level is related to plasma interleukin-6 and a polymorphism in the adrenomedullin gene, Basic & Clinical Pharmacology & Toxicology. Presented at the 10th Congress of the European Association for Clinical Pharmacology and Therapeutics, Budapest. 2011, 109 (Suppl. 1): 102-103.

Cheung B.M.Y., Prospecting for future collaboration opportunities in Asia, 3th Annual Pharmaceutical Law Asia, Singapore. 2010.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Role of genetic variants in gene encoding lipocalin-2 in the development of elevated blood pressure, Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Cheung B.M.Y. and Ong K.L., The Challenge of Managing Hypertension. In: Finkel ML, ed., Public Health in the 21st Century. Santa Barbara, CA: Praeger Publishing. 2010.

Cheung B.M.Y., Triple therapy for hypertension, Sixth International Symposium on Healthy Aging “A New Golden Age", Hong Kong. 2011.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Lam K.S.L., Cherny S.S. and Sham P.C., Using glycosylated haemoglobin to define the metabolic syndrome in United States adults, Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Lam K.S.L., Cherny S.S. and Sham P.C., Using glycosylated hemoglobin to define the metabolic syndrome in United States adults. , Oral Presentation at the 23rd Scientific Meeting of the International Society of Hypertension, Vancouver. 2010.

Cheung B.M.Y., What caused the recent increase in the prevalence of hypertension in Hong Kong Chinese?, The 13th South China International Congress of Cardiology, Guangzhou . 2011.

Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Ong K.L., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., Genetic variants associated with persistent central obesity and the metabolic syndrome in a 12-year longitudinal study, Euro J Endocrinol . 2011, 164: 381-8.

Chu L.W., Tam S., Wong L.C., Yik P.Y., Song Y., Cheung B.M.Y., Morley J.E. and Lam K.S.L., Bioavailable Testosterone Predicts a Lower Risk of Alzheimer's Disease in Older Men, J Alzheimers Dis. 2010, 21(4): 1335-1345.

Deng H., Jiang C.Q., Tomlinson B., Liu B., Lin J.M., Wong K.S., Cheung B.M.Y., Lam T.H. and Thomas G.N., A polymorphism in transforming growth factor-β1 is associated with carotid plaques and increased carotid intima-media thickness in older Chinese men: the Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort, Atherosclerosis. 2010, 214(2): 391-396.

Ferner R.E. and Cheung B.M.Y., Drug therapy: special considerations in diabetes. In: Holt, Flyvbjerg, Goldstein, Cockram, ed., Textbook of diabetes, 4th edition. Oxford: Blackwell. . 2010.

Jiang C.Q., Lam T.H., Liu B., Lin J.M., Yue X.J., Jin Y.L., Cheung B.M.Y. and Thomas G.N., Interleukin-6 receptor gene polymorphism modulates interleukin-6 levels and the metabolic syndrome: GBCS-CVD, Obesity. 2010, 18(10): 1969-1974.

Kumana C.R. and Cheung B.M.Y., Thrombolytic therapy for acute ischaemic stroke: is the hype justified?, Hong Kong Med J. 2011, 17(1): 82-83.

Law L.S.C., Tso A.W.K., Tam S., Wat N.M.S., Cheung B.M.Y. and Lam K.S.L., Haemoglobin A1c is superior to fasting glucose in predicting the incidence of diabetes over 8 years among Chinese, Diabetes Res Clin Pract. 2010, 91(2): e53-6.

Li M., Ho J.C.Y., Lai K.W.H., Au K.W., Xu A., Cheung B.M.Y., Lam K.S.L. and Tse H.F., Hypoadiponectinemia and its Impact on circulating endothelial progenitor cells in patients with type 2 diabetes - adiponectin and endothelial progenitor cells, Diabetes/Metab Res Rev. 2010, 27: 185-94.

Li M. and Cheung B.M.Y., Rise and fall of anti-obesity drugs, World J Diabetes. 2011, 2(2): 19-23.

Li M., Ho J.C.Y., Lai K.W.H., Au K.W., Xu A., Cheung B.M.Y., Lam K.S.L. and Tse H.F., The decrement in circulating endothelial progenitor cells (EPCs) in type 2 diabetes is independent of the severity of the hypoadiponectemia, Diabetes Metab Res Rev. 2011, 27(2): 185-194.

Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Lam T.H., Cheung B.M.Y. and Lam K.S.L., A genetic variant in the gene encoding adrenomedullin predicts the development of dysglycemia over 6.4 years in Chinese, Clin Chim Acta. 2010, 412: 353-7.

Ong K.L., Cheung B.M.Y., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Association of a genetic variant in adrenomedullin gene with its plasma level., Oral Presentation at the Annual Scientific Meeting of the Hong Kong Society of Endocrinology, Metabolism and Reproduction, Hong Kong. 2010.

Ong K.L., Jiang C.Q., Liu B., Jin Y.L., Tso A.W.K., Tam S., Wong K.S., Tomlinson B., Cheung B.M.Y., Lin J.M., Yue X.J., Lam K.S.L., Lam T.H. and Thomas G.N., Association of a genetic variant in the apolipoprotein A5 gene with the metabolic syndrome in Chinese, Clin Endocrinol (Oxf). 2010, 74: 206-13.

Ong K.L., Li M., Tso A.W.K., Xu A., Cherny S.S., Sham P.C., Tse H.F., Lam T.H., Cheung B.M.Y. and Lam K.S.L., Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese. , European Journal of Endocrinology. 2010, 163: 251-257.

Ong K.L., Tso A.W.K., Lam K.S.L., Cherny S.S., Sham P.C. and Cheung B.M.Y., Using glycosylated hemoglobin to define the metabolic syndrome in United States adults, Diabetes Care. 2010, 23: 1856-8.

Poon T.Y., Ong K.L. and Cheung B.M.Y., Review of the Traditional Chinese Medicine formula, Rehmannia Six Formula, on diabetes mellitus and its complications, J Diabetes. 2011, Epub ahead of print.

Samaranayake N.R., Ong K.L., Leung Y.H. and Cheung B.M.Y., Pharmacological management of obesity in the national health and nutrition examination survey (NHANES) 2007-2008), Basic & Clinical Pharmacology & Toxicology. Presented at the 10th Congress of the European Association for Clinical Pharmacology and Therapeutics, Budapest. 2011, 109 (Suppl. 1): 138-139.

Samaranayake N.R., Cheung S.T.D., Chui C.M.W. and Cheung B.M.Y., Reducing the use of inappropriate abbreviations in prescriptions, Presented at the 6th International symposium on healthy ageing of the Research Centre of Heart, Brain, Hormone & Healthy Aging, The University of Hong Kong. 2011.

Thomas G.N., Jiang C.Q., Taheri S., Xiao Z.H., Tomlinson B., Cheung B.M.Y., Lam T.H., Barnett A.H. and Cheng K.K., A systematic review of lifestyle modification and glucose intolerance in the prevention of type 2 diabetes, Current Diabetes Reviews. 2010, 6(6): 378-387.

Tso A.W.K., Lam T.K.Y., Xu A., Yiu K.H., Tse H.F., Li L.S.W., Law S.C., Cheung B.M.Y., Cheung R.T.F. and Lam K.S.L., Serum adipocyte fatty acid-binding protein is associated with ischemic stroke and early death, Neurology. 2011, 76(23): 1968-75.

Yiu K.H., Cheung B.M.Y. and Tse H.F., Pharmacological treatment for systolic heart failure. In Lip GY, Tse HF, Oxford: Oxford Univeristy Press. 2011.

Yiu Y.F., Chan Y.H., Yiu K.H., Siu D.C.W., Li L.S.W., Wong L.Y., Lee S.W.L., Tam S., Wong E.W.K., Cheung B.M.Y. and Tse H.F., Vitamin D deficiency is associated with depletion of circulating endothelial progenitor cells and endothelial dysfunction in patients with type 2 diabetes. , J Clin Endocrinol Metab. 2011, 96(5): E830-835.

Researcher : Cheung CL

Project Title:	Genome-Wide Association and Gene-and-Environment Interaction Studies of Vitamin D Insufficiency in Southern Chinese
Investigator(s):	Cheung CL, Kung AWC
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	02/2011

Project Title:	3rd Joint Meeting of the European Calcified Tissue Society and the International Bone and Mineral Society IDENTIFICATION OF QTL GENES FOR BMD VARIATION USING BOTH LINKAGE AND GENE-BASED ASSOCIATION APPROACHES
Investigator(s):	Cheung CL
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	05/2011
Completion Date:	05/2011

List of Research Outputs

Bow C.H.Y., Leung E., Cheung C.L., Xiao S., Loong C., Soong S.S., Tan K.C.B., Luckey M.M., Cauley J.A., Fujiwara S. and Kung A.W.C., Ethnic Difference of Clinical Vertebral Fracture Risk, 12th Regional Osteoporosis Conference, Hong Kong. 2011.

Bow C.H.Y., Cheung E., Cheung C.L., Xiao S., Loong C., Soong S.S., Tan K.C.B., Luckey M.M., Cauley J.A., Fujiwara S. and Kung A.W.C., Ethnic difference of clinical vertebral fracture risk, Osteoporosis International. 2011.

Cheung C.L., Best Oral Presentation (Clinical), 2010 Annual Meeting of the Hong Kong Society of Endocrinology, Metabolism and Reproduction. 2010.

Cheung C.L., Xiao S. and Kung A.W.C., Genetic epidemiology of age-related osteoporosis and its clinical application, Nature Reviews Rheumatology. 2010, 6(9): 507-517.

Cheung C.L., Invited Reviewer, Human Genetics. 2011.

Cheung C.L., New Investigator Award, 2011 Joint conference of European Calcified Tissue Society and International Bone and Mineral Society. 2011.

Li H.Y., Cheung C.L., Xiao S., Lau K.S., Gao Y., Bow C.H.Y., Huang Q.Y., Sham P.C. and Kung A.W.C., Identification Of Qtl Genes For Bmd Variation Using Both Linkage And Gene-based Association Approaches., Human Genetics. 2011.

Xiao S., Gao Y., Cheung C.L., Bow C.H.Y., Lau K.S., Sham P.C., Tan K.C.B. and Kung A.W.C., Association of Cdx1 Binding Site of Periostin Gene with Bone Mineral Density and Vertebral Fracture Risk, The 3rd Joint Meeting of the European Calcified Tissue Society and the International Bone and Mineral Society, 7-11 MAY, Athens, Greece. Athens, Greece, 2011, 7-11 MAY.

Researcher : Cheung CM

List of Research Outputs

Gao J., Cheung R.T.F., Lee T.M.C., Chu L.W., Cheung C.M., Fung G., Qiu D.Q. and Chan Y.S., The antero-posterior pattern of white matter decline in normal and abnormal ageing supports retrogenesis: a diffusion tensor imaging study, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 58.. 2010.

Researcher : Cheung KF

List of Research Outputs

Yung S.S.Y., Cheung K.F., Zhang Q. and Chan D.T.M., Anti-dsDNA antibodies bind to mesangial annexin II in lupus nephritis. 2010 Nov;21(11):1912-27., Journal of American Society of Nephrology. 2010, 21: 1912-17.

Yung S.S.Y., Cheung K.F., Zhang Q. and Chan D.T.M., Anti-dsDNA antibodies from patients with lupus nephritis bind to annexin II on human mesangial cells, Journal of the American Society of Nephrology. 2010, 21: 755A.

Researcher : Cheung KF

List of Research Outputs

Researcher : Cheung PPY

List of Research Outputs

Cheung P.P.Y., Chin W.Y. and Jong I., Home Blood Pressure Monitoring in the Management of Hypertensive Patients , Hong Kong Practitioner. 2010.

Researcher : Cheung RTF

Project Title:	Role of ischemia in Alzheimer's disease - an experimental study in transgenic mice
Investigator(s):	Cheung RTF
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Project Title:	Development of Chinese-language versions of internationally-accepted stroke training materials for healthcare professionals treating Chinese stroke patients
Investigator(s):	Cheung RTF
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	04/2005

Project Title:	The effects of self-assembling peptide nanofiber scaffold (SAPNS) in a renovascular hypertensive (RVHT) rat model of intracerebral hemorrhage (ICH). Part II: evaluation of SAPNS in the RVHT rat model of ICH
Investigator(s):	Cheung RTF
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2008
Completion Date:	10/2010

Project Title:	Neuroprotective effects of melatonin and/or electro-acupuncture (EA) on focal cerebral ischemia in rats
Investigator(s):	Cheung RTF
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2009

Project Title:	Evaluation of key mechanisms of brain injury and of a novel hemostatic treatment in a rat model of hypertensive intracerebral hemorrhage
Investigator(s):	Cheung RTF, Ellis-Behnke RG, So KF, Wu EX
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010

Project Title:	Transplantation of neural stem cells in a rat model of intracerebral hemorrhage
Investigator(s):	Cheung RTF
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2010

List of Research Outputs

Chang R.S.K., Mak W., Cheung R.T.F. and Ho S.L., Risk factors, clinical presentation and prognosis of perioperative stroke: a retrospective case-control study, 63rd Annual Meeting of the American Academy of Neurology. 2011, 76 (Suppl 4): A60.

Cheung R.T.F., Amnesia - Recovery of Lost Memory, Public Lecture Series, Hong Kong Brain Foundation Limited. 2010.

Cheung R.T.F., Assistant Editor, Stroke. Wiley-Blackwell, 2011.

Cheung R.T.F., Commentary: Training speech-language pathology graduate clinicians to administer the National Institutes of Health Stroke Scale, International Journal of Therapy and Rehabilitation. 2010, 17: 422.

Cheung R.T.F., Editorial Board, Chinese Journal of Neurology. Chinese Medical Association, 2011.

Cheung R.T.F., Editorial Board, Chinese version of Stroke. 2011.

Cheung R.T.F., Editorial Board, Journal of Pineal Research. Blackwell Publishing, 2011.

Cheung R.T.F., Editorial Board, Medical Progress. CMPMedica, 2010.

Cheung R.T.F., Editorial Board, Reviews on Recent Clinical Trials. Bentham Science Publishers, 2011.

Cheung R.T.F., Editorial Board, Stroke Research and Treatment. Hindawi Publishing Corporation, 2011.

Cheung R.T.F., Editorial Board, The Open Medical Imaging Journal. Bentham Science Publishers, 2011.

Cheung R.T.F., Editorial Board, The Open Neuroimaging Journal. Bentham Science Publishers, 2011.

Cheung R.T.F., Editorial Board, The Open Nuclear Medicine Journal. Bentham Science Publishers, 2011.

Cheung R.T.F., Editorial Board, The Open Physiology Journal. Bentham Science Publishers, 2011.

Cheung R.T.F., Melatonin in Cerebrovascular Disease, Role of Melatonin in Metabolic Regulation, BIT Life Sciences’ First Annual World Congress of Endobolism 2011. 2011.

Cheung R.T.F., Member of Organizing Committee & Chairman of Symposium VIII: New Therapies in Stroke, Sixth International Symposium on Healthy Aging: A New Golden Age? Research Centre of Heart, Brain, Hormone & Healthy Aging, Faculty of Medicine, HKU, 5-6 March 2011, Sheraton Hong Kong Hotel & Towers, Tsimshatsui, Hong Kong . 2011.

Cheung R.T.F., Member of Organizing Committee & Chairman of Symposium on Physics & Neurophysiology , Hong Kong International Acupuncture Conference, Hong Kong Association of Integration of Chinese-Western Medicine, Hong Kong Academy of Medicine, Wong Chuk Hang, Hong Kong . 2011.

Cheung R.T.F., Stroke Prevention & Antiplatelet Agents, Doctors Union Meeting. 2010.

Cheung R.T.F., The Effect of Acupuncture on Brain Injury Due to Stroke, Stroke & Parkinson’s Disease, Hong Kong International Acupuncture Conference 2011. 2011.

Gao J., Wong W., Mak W. and Cheung R.T.F., An event-related potential study on the information flow during prospective memory interference, Sixteenth Medical Research Conference. 2011, 17 (Suppl 1): 26.

Gao J., Cheung R.T.F., Lee T.M.C., Chu L.W. and Chan Y.S., Task-induced brain deactivation alters the functional connectivity of neural network in aging, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 59-60. 2010.

Gao J., Cheung R.T.F., Lee T.M.C., Chu L.W., Cheung C.M., Fung G., Qiu D.Q. and Chan Y.S., The antero-posterior pattern of white matter decline in normal and abnormal ageing supports retrogenesis: a diffusion tensor imaging study, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 58.. 2010.

Gao J., Cheung R.T.F., Lee T.M.C., Chu L.W. and Chan Y.S., The effect of normal and abnormal ageing on prospective memory showed increased cognitive conflict: a functional MRI study, Sixteenth Medical Research Conference. 2011, 17 (Suppl 1): 51.

Gao J., Cheung R.T.F., Lee T.M.C., Chu L.W. and Chan Y.S., The effect of normal and abnormal ageing on prospective memory showed increased cognitive conflict: a functional MRI study, Hong Kong Medical Journal, 17: 27. [16^th Medical Research Conference. H.K. Jan. 22, 2011]. 2011.

Kwan M.W., Mak W., Cheung R.T.F. and Ho S.L., Ischemic stroke related to intracranial branch atheromatous disease and comparison with large and small artery diseases, J Neurol Sci. . J Neurol Sci., 2011, 303(1-2):: 80-4.

Sang Y., Su H., Yang X., Liu L.G., Wu W. and Cheung R.T.F., Neural stem cell transplantation in a rat model of intracerebral haemorrhage plus haematoma aspiration, Sixteenth Medical Research Conference. 2011, 17 (Suppl 1): 51.

Tse M.Y.M., Li L.S.W., Cheung R.T.F. and Kwok T.K., Impact of stroke on autonomic nervous system, Sixteenth Medical Research Conference. 2011, 17 (Suppl 1): 56.

Tse M.Y.M., Li L.S.W. and Cheung R.T.F., Post-stroke orthostatic hypotension, its pattern of recovery, Sixteenth Medical Research Conference. 2011, 17 (Suppl 1): 55.

Tso A.W.K., Lam T.K.Y., Xu A., Yiu K.H., Tse H.F., Li L.S.W., Law S.C., Cheung B.M.Y., Cheung R.T.F. and Lam K.S.L., Serum adipocyte fatty acid-binding protein is associated with ischemic stroke and early death, Neurology. 2011, 76(23): 1968-75.

Researcher : Cheung TK

List of Research Outputs

Lam P.K.Y., Ng M.L., Cheung T.K., Wong B.Y.H., Tan V.P.Y., Fong D.Y.T., Wei W.I. and Wong B.C.Y., Rabeprazole is effective in treating laryngopharyngeal reflux, In: C. Mel Wilcox, M.D., Clinical Gastroenterology and Hepatology. Elsevier, 2010, 8: 770-776.

Yuen R.M.F., Lee C.K., Wong D.K.H., Fung J.Y.Y., Hung I.F.N., Hsu A., But D.Y.K., Cheung T.K., Chan P., Yuen J.C.H., Fung F.K.C., Seto W.K., Lin C.K. and Lai C.L., Prevalence of occult hepatitis B infection in a highly endemicea for chronic hepatitis B: A study of large blood-donor population, GUT. 2010, 59(10): 1389-93.

Researcher : Cheung WWW

List of Research Outputs

Tse E.W.C., So J.C.C., Cheung W.W.W. and Kwong Y.L., T-cell prolymphocytic leukaemia: spontaneous immunophenotypical switch from CD4 to CD8 expression, Ann Hematol. 2010, 90(4): 479-81.

Researcher : Cheung YY

List of Research Outputs

Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Ong K.L., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., Genetic variants associated with persistent central obesity and the metabolic syndrome in a 12-year longitudinal study, Euro J Endocrinol . 2011, 164: 381-8.

Researcher : Chim JCS

Project Title:	The role of aberrant promoter methylation of tumor suppressor micro-RNA in chronic lymphocytic leukemia (CLL)
Investigator(s):	Chim JCS, Liang RHS
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2008
Completion Date:	12/2010

Project Title:	FISH study and the use of bortezomib in high-risk multiple myeloma
Investigator(s):	Chim JCS
Department:	Medicine
Source(s) of Funding:	Lee Hysan Foundation - General Award
Start Date:	07/2008

Project Title:	Study of tumor suppressor function of miR-124a in non-Hodgkin's lymphoma
Investigator(s):	Chim JCS
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2009
Completion Date:	06/2011

Project Title:	Functional study of the impact of hypermethylation of tumor suppressive micro-RNA in myeloma stem cells
Investigator(s):	Chim JCS, Liang RHS
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010

Project Title:	Methylation of miR-129 in hematological cancers
Investigator(s):	Chim JCS
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2011

List of Research Outputs

Chim J.C.S., A staged approach with vincristine, adriamycin and dexamethasone followed by bortezomib, thalidomide and dexamethasone before autologous hematopoietic stem cell transplantation in the treatment of newly diagnosed multiple myeloma, Health Research Symposium 2010: Improving health and recognising excellence, Hong Kong Academy of Medicine, the Food and Health Bureau, Hong Kong (Abstract). 2010.

Chim J.C.S., American Journal of Translational Research, 2011.

Chim J.C.S., Blood Cancer Journal (http://www.nature.com/bcj/about/index.html#Editors) , 2011.

Chim J.C.S., Bone Marrow Transplantation (impact factor :3.6) , 2011.

Chim J.C.S., Cancer Treatment in the Era of Targeted Therapy: the March is on!, Hong Kong Medical Diary. 2011, 2-3.

Chim J.C.S., Carcinogenesis (impact factor :5.4) , 2011.

Chim J.C.S., Current Oncology Reports (impact factor: 2.40), 2011.

Chim J.C.S., Wong K.Y., Leung C.Y., Chung L.P., Hui P.K., Chan S.Y. and Yu L., Epigenetic inactivation of the hsa-miR-203 in haematological malignancies, J Cell Mol Med. 2011, [Epub ahead of print].

Chim J.C.S., Epigenetics in Myeloma, Bridging the Gap, 2nd International Hematologic Malignancy Conference, jointly organized by the MD Anderson Cancer and the National University of Singapore. 2011.

Chim J.C.S., Gene hypermethylation in hematological Cancers, PLA 301 Hospital, Beijing. 2010.

Chim J.C.S., Gene hypermethylation in hematological Cancers, Peking Union Medical College Hospital, Beijing. 2010.

Chim J.C.S., Hepatitis B reactivation in Lymphoma, Hong Kong Economic Times. 2010.

Chim J.C.S., ISRN Hematology, 2010.

Chim J.C.S., Sim J.P., Chan C.C., Kho B.C., Chan J.C., Wong L.G., Law M., Liang R.H.S. and Kwong Y.L., Impact of JAK2V617F mutation on thrombosis and myeloid transformation in essential thrombocythemia: a multivariate analysis by Cox regression in 141 patients , Haematology. 2010, 15(4): 187-92.

Chim J.C.S., International Journal of Oncology (impact factor: 2.295) , 2011.

Chim J.C.S., International Journal of Oncology (impact factor: 2.57) , 2011.

Chim J.C.S., Journal of Translational Medicine (impact factor: 3.5) , 2010.

Chim J.C.S., Wan T.S., Fung T.K. and Wong K.F., Methylation of TET2, CBL and CEBPA in Ph-negative myeloproliferative neoplasms , Journal of Clinical Pathology. 2010, 63(6): 518-21.

Chim J.C.S., Myeloma infiltration of the lung, Apple Daily. 2010.

Chim J.C.S., PLoS ONE (impact factor: 4.41), 2010.

Chim J.C.S., The Asia-Pacific Journal of Oncology and Hematology. 2011.

Chim J.C.S., The Hong Kong Medical Diary. 2011.

Chim J.C.S., The Open Leukemia Journal. 2010.

Chim J.C.S., The Open Pathology Journal. 2011.

Chim J.C.S., The Open Translational Medicine Journal. 2010.

Chim J.C.S., To Optimise Myeloma Treatment in the Era of Targeted Therapy, Hong Kong Medical Diary. 2011, 7-9.

Chim J.C.S., Translational Oncology (impact factor: 2.40), 2011.

Chim J.C.S., Updated survivals and prognostic factor analysis in myeloma treated by a staged approach use of bortezomib/thalidlomide/dexamethasone in transplant eligible patients, Journal of Translational Medicine. 2010, under review.

Chim J.C.S., 《白血病•淋巴瘤》雜誌 , 2011.

Gill H., Chim J.C.S., Au W.Y., Loong F., Tse E.W.C., Leung A.Y.H. and Kwong Y.L., Non-gastric marginal zone B cell lymphoma: clinicopathologic features and treatment results, Ann Hematol. 2011, [Epub ahead of print].

MA T.W., Lo C.L.R., CHENG Y.U.E. and Chim J.C.S., Multiple myeloma presenting as interstitial lung disease, Journal of Clinical Oncology. 2011.

Ma A.T.W., Lo R., Cheng Y. and Chim J.C.S., Multiple Myeloma Presenting as Interstitial Lung Disease, Journal of Clinical Oncology. 2010, in press.

Wong K.Y., Yu L. and Chim J.C.S., DNA methylation of tumor suppressor microRNA genes: a lesson from miR-34 family, Epigenomics. 2011, 3(1): 83-92.

Wong K.Y., So J.C.C., Loong F., Chung L.P., Lam W.W.L., Liang R.H.S., Jin D. and Chim J.C.S., Epigenetic inactivation of the miR-124-1 in haematological malignancies, PLoS One. 2011, 22;6(4).

Wong K.Y., Liang R.H.S., So J.C.C., Jin D., Costello J.F. and Chim J.C.S., Epigenetic silencing of MIR203 in multiple myeloma, Br J Haematol. 2011, [Epub ahead of print].

Wong K.Y., Liang R.H.S., So C.H.I.-.C.H.I.U., Qi Y.A.N.T.I.N.G., Jin D.O.N.G.-.Y.A.N., Costello J.O.S.E.P.H. .F... and Chim J.C.S., Epigenetic silencing of miR-203 in multiple myeloma, Br J Haematol. 2011, [Epub ahead of print].

Zou B., Chim J.C.S., Pang R.W.C., Zeng H.U.I., Dai Y., Zhang R., Lam S.C., Tan V.P.Y., Hung I.F.N. and Lan H.Y., XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification, Mol Carcinog. 2011.

Zou B., Chim J.C.S., Pang R.W.C., Zeng H.U.I., Dai Y., Zhang R., Lam S.C., Tan V.P.Y., Hung I.F.N., Lan H.Y. and Wong B.C.Y., XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification, Molecular Carcinogenesis. 2010, under review.

Researcher : Chin WY

Project Title:	Developing a set of quality criteria for community-based medical education in Hong Kong
Investigator(s):	Chin WY, Johnston JM, Cheung ANY, Lam CLK
Department:	Med - Family Medicine Unit
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2010

Project Title:	The epidemiology and natural history of depressive disorders in primary care
Investigator(s):	Chin WY, Lam CLK, Lo YYC, Fong DYT, Lam TP, Lee PWH
Department:	Med - Family Medicine Unit
Source(s) of Funding:	Commissioned Research on Mental Health Policy and Services
Start Date:	05/2010

List of Research Outputs

Cheung P.P.Y., Chin W.Y. and Jong I., Home Blood Pressure Monitoring in the Management of Hypertensive Patients , Hong Kong Practitioner. 2010.

Researcher : Chiu PKC

List of Research Outputs

Chan K.K., Chiu P.K.C. and Chu L.W., Association between Alcohol Consumption and Cognitive Impairment in Southern Chinese Older Adults., Int J Geriatr Psychiatry. . 2010, 25(12): 1272-9.

Chu L.W., Luk J.K.H., Hui E., Chiu P.K.C., Chan S.Y., Kwan S.M., Kwok T., Lee D. and Woo J., Advance directive and end-of-life care preferences among Chinese nursing home residents in Hong Kong, J Am Med Dir Assoc. . 2011, 12(2): 143-52.

Luk J.K.H., Chiu P.K.C. and Chu L.W., Gender differences in rehabilitation outcomes among older Chinese patients, Arch Gerontol Geriatr.. 2011, 52(1): 28-32.

Researcher : Chong BH

List of Research Outputs

Yue W., Chong B.H., Zhang X., Liao S., Jim M.H., Kung A.W.C., Tse H.F. and Siu D.C.W., Hyperthyroidism-induced left ventricular diastolic dysfunction: implication in hyperthyroidism-related heart failure, Clin Endocrinol (Oxf). 2011, 74(5): 636-43.

Researcher : Chow WS

List of Research Outputs

Lam J.K.Y., Lam K.S.L., Kung A.W.C., Tan K.C.B., Chow W.S. and Tso A.W.K., A woman with raised alkaline phosphatase and forearm deformity, BMJ. 2011, 342: d3435.

Leung G.K.K., Yuen M.M.A., Chow W.S., Tse P.Y.H. and Lui W.M., An endoscopic modification of the simultaneous ‘above and below’ approach to large pituitary adenomas , Pituitary. 2011.

Yuen M.M.A., Tam T.C.C., Lau W.W.Y., Chan J.F.W., Chow W.S. and Lam K.S.L., An unforeseen complication of urinary trail infection in a diabetic patient, BMJ. 2010, 341: c3073.

Researcher : Choy CBY

List of Research Outputs

Yap D.Y.H., Tang C.S.O., Yung S.S.Y., Choy C.B.Y., Yuen R.M.F. and Chan D.T.M., Long-term outcome of renal transplant recipients with chronic hepatitis B infection - impact of antiviral treatments, Transplantation. 2010, 90(3): 325-330.

Researcher : Chu ACY

List of Research Outputs

Chan K.H., Kwan S.C., Ho W.L., Ho W.M., Chu A.C.Y. and Ramsden D.B., Aquaporin-4 autoantibodies in neuromyelitis optica spectrum disorders: comparison between tissue-based and cell-based indirect immunofluorescence assays, Journal of Neuroinflammation. 2010, 7(1): 50.

Researcher : Chu LW

Project Title:	A dementia outreach programme in Central, Western and Southern districts of Hong Kong
Investigator(s):	Chu LW, Lam KSL, Lee PWH
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	09/2003

List of Research Outputs

Chan I.W.P., Chu L.W., Lee P.W.H., Li S.W. and Yu G.K.K., Effects of cognitive function and depressive mood on the quality of life in Chinese Alzheimer’s disease patients in Hong Kong., Geriatr Gerontol Int.. 2011, 11(1): 69-76.

Chan K.K., Chiu P.K.C. and Chu L.W., Association between Alcohol Consumption and Cognitive Impairment in Southern Chinese Older Adults., Int J Geriatr Psychiatry. . 2010, 25(12): 1272-9.

Chen L., Kao P.Y.P., Fan Y., Chu L.W. and Song Y., Association between Complement Receptor 1 Polymorphisms and Alzheimer's Disease in Southern Chinese Population , 15 th Research Postgraduate Symposium, HKU, 1 & 2 Dec 2010. HK.

Chiu P.W., Mak H.K.F., Chan Q., Yau K.K.W. and Chu L.W., Proton (1H) Magnetic Resonance Spectroscopy: Absolute metabolite concentrations in normal aging human brain at 3Tesla. , ISMRM 19th Scientific Meeting and Exhibition, Montreal, Canada, 7-13 May, 2011.. 2011.

Chiu P.W., Mak H.K.F., Chan Q., Yau K.K.W. and Chu L.W., Proton (1H) Magnetic Resonance Spectroscopy: Absolute metabolite concentrations in normal aging human brain at 3Tesla. The Croucher Foundation Conference – Alzheimer’s Disease Conference 2011: From Public Health , Basic and Clinical Sciences to Therapeutic Insights, Hong Kong, 26-27 May, 2011 (oral)., 2011.

Chu L.W., Luk J.K.H., Hui E., Chiu P.K.C., Chan S.Y., Kwan S.M., Kwok T., Lee D. and Woo J., Advance directive and end-of-life care preferences among Chinese nursing home residents in Hong Kong, J Am Med Dir Assoc. . 2011, 12(2): 143-52.

Chu L.W., McGhee S., Luk J.K.H., Kwok T., Hui E., Chiu P.K.C., Lee D.T.F. and Woo J., Advance directive and preference of old age home residents for community model of end-of-life care in Hong Kong, Hong Kong Medical Journal. 2011, 17(Suppl 3): S13-S15.

Chu L.W., Tam S., Wong L.C., Yik P.Y., Song Y., Cheung B.M.Y., Morley J.E. and Lam K.S.L., Bioavailable Testosterone Predicts a Lower Risk of Alzheimer's Disease in Older Men, J Alzheimers Dis. 2010, 21(4): 1335-1345.

Gao J., Cheung R.T.F., Lee T.M.C., Chu L.W. and Chan Y.S., Task-induced brain deactivation alters the functional connectivity of neural network in aging, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 59-60. 2010.

Gao J., Cheung R.T.F., Lee T.M.C., Chu L.W., Cheung C.M., Fung G., Qiu D.Q. and Chan Y.S., The antero-posterior pattern of white matter decline in normal and abnormal ageing supports retrogenesis: a diffusion tensor imaging study, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 58.. 2010.

Gao J., Cheung R.T.F., Lee T.M.C., Chu L.W. and Chan Y.S., The effect of normal and abnormal ageing on prospective memory showed increased cognitive conflict: a functional MRI study, Sixteenth Medical Research Conference. 2011, 17 (Suppl 1): 51.

Gao J., Cheung R.T.F., Lee T.M.C., Chu L.W. and Chan Y.S., The effect of normal and abnormal ageing on prospective memory showed increased cognitive conflict: a functional MRI study, Hong Kong Medical Journal, 17: 27. [16^th Medical Research Conference. H.K. Jan. 22, 2011]. 2011.

Lee A.M., Chu L.W., Chong C.S., Chan S.Y., Tam S., Lam K.S.L. and Lam T.P., Relationship between symptoms of androgen deficiency and psychological factors and quality of life among Chinese men, Int J Androl. 2010, 33(5): 755-63.

Li Y., Chu L.W., Wang B., Yik P.Y., Huriletemuer I., Jin D., Ma X. and Song Y., Cyp46a1 Functional Promoter Haplotypes Decipher Genetic Susceptibility To Alzheimer's Disease, Journal Of Alzheimer's Disease. IOS Press, 2010, 21(4): 1311-23.

Luk J.K.H., Chiu P.K.C. and Chu L.W., Gender differences in rehabilitation outcomes among older Chinese patients, Arch Gerontol Geriatr.. 2011, 52(1): 28-32.

Mak H.K.F., Zhang Z., Yau K.K.W., Zhang L., Chan Q. and Chu L.W., Efficacy of manual hippocampal volumetry and Voxel-based morphometry (VBM) as imaging biomarkers in a Chinese cohort of Alzheimer's patients (AD) and cognitively normal older adults. , Alzheimer's Association International conference on Alzheimer's disease 2010, July 10-15, Honoluluis, U.S.A. (Poster). 2010.

Mak H.K.F., Zhang Z., Yau K.K.W., Zhang L., Chan Q. and Chu L.W., Efficacy of voxel-based morphometry with DARTEL and standard registration as imaging biomarkers in Alzheimer's patients and cognitively normal older adults at 3.0 Tesla MR Imaging. , Journal of Alzheimer's Disease. 2011, 23: 655-664.

Sun D., Lee T.M.C., Chu L.W., Mak H.K.F. and Leung M.K., Affective Perception In Alzheimer’s Disease, Croucher Foundation Conference Alzheimer’s Disease Conference 2011: From Public Health, Basic and Clinical Sciences to Therapeutic Insights, Hong Kong. 2011.

Zhou L., Chu L.W., Kwan S.C., Lam K.S.L., Ho W.L., Ho W.M. and Chan K.H., Plasma amyloid beta peptides and oligomers antibodies in Alzheimer's disease, 16th Medical Research Conference, Department of Medicine, The University of Hong Kong, 2011. Hong Kong Medical Journal . 2011, 17 (Supplement 1): 69.

Zhou L., Chu L.W., Kwan S.C., Lam K.S.L., Ho W.L., Ho W.M. and Chan K.H., Plasma amyloid beta peptides and oligomers levels in Alzheimer's disease, 16th Medical Research Conference, Department of Medicine, The University of Hong Kong, 2011. Hong Kong Medical Journal. 2011, 17 (Supplement 1): 69.

Zhou L., Chu L.W., Kwan S.C., Lam K.S.L., Ho W.L., Ho W.M. and Chan K.H., Plasma beta-amyloid peptides and serum associated beta-amyloid autoantibodies in patients with Alzheimer's disease, Alzheimer's Disease Conference 2011: From Public Health, Basci And Clinical Sciences To Therapeutic Insights. 2011.

Zhou L., Chu L.W., Kwan S.C., Lam K.S.L., Ho W.L., Ho W.M. and Chan K.H., Plasma b-amyloid Peptides And Serum Associated b-amyloid Autoantibodies In Alzheimer's Disease, Sixth International Symposium On Healthy Aging. 2011.

Researcher : Chu YW

List of Research Outputs

McManus A.M., Chu Y.W., Yu C.W. and Hu Y., How children move - activity pattern characteristics in lean and obese children., Journal of Obesity. 2011, 2011: 679328.

Researcher : Chung ACK

Project Title:	Signaling mechanisms of angiotensin II-induced epithelial-mesenchymal transition in renal tubular epithelial cells
Investigator(s):	Chung ACK, Lan HY
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2008

Researcher : Chung CP

List of Research Outputs

Chan K.H., Tse C. .T., Chung C.P., Lee R., Kwan S.C., Ho W.L. and Ho W.M., Brain Involvement In Neuromyelitis Optica Spectrum Disorders, Archives of Neurology. 2011, 68(11): 1432-1439.

Tse C.T., Chung C.P., Tse M.M.Y., Ho S.L., Cheung K.S., Kwan S.C., Ho W.L., Ho W.M. and Chan K.H., Cerebral involvement in neuromyelitis optica spectrum disorders among Hong Kong Chinese, 16th Medical Research Conference, Department of Medicine, The University of Hong Kong, 2011. Hong Kong Medical Journal. 2011, 17 (Supplement 1): 55.

Researcher : Chung IS

List of Research Outputs

Fung T.K., Chung I.S., Liang R.H.S. and Leung A.Y.H., Role of a novel zebrafish nup98 during embryonic development, Experimental Hematology. 2010, Epub.

Ma C.H., Chung I.S., Liang R.H.S. and Leung A.Y.H., A DEAB-sensitive aldehyde dehydrogenase regulates hematopoietic stem and progenitor cells development during primitive hematopoiesis in zebrafish embryos, Leukemia. Nature Publishing Group, 2010, 24: 2090-2099.

Ma C.H., Chung I.S., Lin H., Yang D. and Leung A.Y.H., Methionine aminopeptidase II in zebrafish definitive hematopoiesis, Hong Kong Society of Developmental Biology. 2011.

Researcher : Chung IS

List of Research Outputs

Fung T.K., Chung I.S., Liang R.H.S. and Leung A.Y.H., Role of a novel zebrafish nup98 during embryonic development, Experimental Hematology. 2010, Epub.

Ma C.H., Chung I.S., Lin H., Yang D. and Leung A.Y.H., Methionine aminopeptidase II in zebrafish definitive hematopoiesis, Hong Kong Society of Developmental Biology. 2011.

Researcher : Dai Y

List of Research Outputs

Zou B., Chim J.C.S., Pang R.W.C., Zeng H.U.I., Dai Y., Zhang R., Lam S.C., Tan V.P.Y., Hung I.F.N. and Lan H.Y., XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification, Mol Carcinog. 2011.

Zou B., Chim J.C.S., Pang R.W.C., Zeng H.U.I., Dai Y., Zhang R., Lam S.C., Tan V.P.Y., Hung I.F.N., Lan H.Y. and Wong B.C.Y., XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification, Molecular Carcinogenesis. 2010, under review.

Researcher : Dai YLE

List of Research Outputs

Yan G., Wang M.M., Yue W., Luk T.H., Dai Y.L.E., Siu D.C.W., Yiu K.H., Lee S.W.L. and Tse H.F., Coenzyme Q10 Supplementation Improves Left Ventricular Torsion In Patients With Ischemic Cardiomyopathy, AHA. 2010.

Researcher : Dai Z

List of Research Outputs

Dai Z., Chung S.K., Miao D., Lau K.S., Chan A.W.H. and Kung A.W.C., Sodium/myo-inositol cotransporter 1 and myo-inositol are essential for osteogenesis and bone formation, Journal of Bone and Mineral Research. 2011, 26(3): 582-590.

Researcher : Dong M

Project Title:	Regulation of human ether-à-go-go gene K+ channels by EGFR kinase
Investigator(s):	Dong M, Li GR
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	10/2010
Completion Date:	06/2011

List of Research Outputs

Li G.R. and Dong M., Pharmacology of cardiac potassium channels, Adv Pharmacol. San Diego, Calif, 2010, 59: 93-134.

Li G.R. and Dong M., Revisit of the Cardiac Inward Rectifier Potassium Current IK1, The Open Circulation & Vascular Journal. 2010, 3: 95-102.

Researcher : Feng Z

Project Title:	30th Annual Meeting of the Society for Neuroscience Identifying and Cloning of B218 Gene, which was Down Regulated by Kainic Acid Treatment and in the Developmental Stages
Investigator(s):	Feng Z
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	11/2000

Researcher : Fung FKC

List of Research Outputs

Yuen R.M.F., Lee C.K., Wong D.K.H., Fung J.Y.Y., Hung I.F.N., Hsu A., But D.Y.K., Cheung T.K., Chan P., Yuen J.C.H., Fung F.K.C., Seto W.K., Lin C.K. and Lai C.L., Prevalence of occult hepatitis B infection in a highly endemicea for chronic hepatitis B: A study of large blood-donor population, GUT. 2010, 59(10): 1389-93.

Researcher : Fung JYY

List of Research Outputs

But D.Y., Yuen R.M.F., Fung J.Y.Y. and Lai C.L., Safety evaluation of telbivudine., Expert Opin Drug Saf. 2010, 9(5): 821-9.

Cheung C.K.Y., Fung J.Y.Y., Man K. and Lo C.M., Young Investigator Travel Award - Differential replication of hepatitis B virus mutants in recurrent hepatocellular carcinoma after liver transplantation (Abstract), The 2011 Joint International Congress of ILTS, ELITA, & LICAGE, Valencia, Spain, 22-25 June 2011. 2011.

Dai W.C., Chan S.C., Chok K.S.H., Cheung T.T., Sharr W.W., Chan A.C.Y., Fung J.Y.Y., Tsang S.H.Y., Fan S.T. and Lo C.M., Single-centre experience of liver transplantation for familial amyloidotic polyneuropathy of non-Val30Met variant in Chinese patients (Poster Presentation), 2011 Joint International Congress of ILTS, ELITA & LICAGE, Valencia, Spain, 22-25 June 2011.

Fung J.Y.Y., Chan S.C., Yuen M.F., Chok K.S.H., Sharr W.W., Fan S.T., Dai J., Seto W.K. and Lo C.M., Entecavir monotherapy is effective in viral suppression after liver transplantation for hepatitis B (Abstract), 2011 Joint International Congress of ILTS, ELITA & LICAGE, Valencia, Spain, 22-25 June 2011.

Fung J.Y.Y., Chan S.C., Yuen R.M.F., Chok K.S.H., Sharr W.W., Fan S.T., Dai J., Seto W.K. and Lo C.M., Entecavir monotherapy is effective in viral suppression after liver transplantation for hepatitis B. , Liver Transpl . 2011, 17(6 Supp 1): S94.

Fung J.Y.Y., Lai C.L., Cheng C.T.K., Wu C.H., Wong D.K.H. and Yuen R.M.F., Mild-to-moderate elevation of alanine aminotransferase increases liver stiffness measurement by transient elastography in patients with chronic hepatitis B. [Epub 2010 Dec 14], Am J Gastroenterol . 2010, 106(3): 492-6.

Fung J.Y.Y., Seto W.K., Lai C.L., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Profiles of HBV DNA in a large population of Chinese patients with chronic hepatitis B: implications for antiviral therapy., Journal of hepatology : the journal of the European Association for the Study of the Liver. 2011, 54: 195-200.

Fung J.Y.Y., Lai C.L., Seto W.K., Wong D.K.H. and Yuen R.M.F., Prognostic significance of liver stiffness for hepatocellular carcinoma and mortality in HBeAg-negative chronic hepatitis B., Journal of Viral Hepatitis. 2010, [Epub ahead of print].

Fung J.Y.Y., Lai C.L., Yuen J.C.H., Cheng C.T.K., Wu C.H., Wong D.K.H., Seto W.K., Hung I.F.N. and Yuen R.M.F., Randomized trial of lamivudine versus entecavir in entecavir-treated patients with undetectable hepatitis B virus DNA: Outcome at 2 years., Hepatology. 2011, 53(4): 1148-53.

Fung J.Y.Y., Lai C.L., But D.Y.K., Hsu A.S.J., Seto W.K., Cheng C.T.K., Wong D.K.H. and Yuen R.M.F., Reduction of liver stiffness following resolution of acute flares of chronic hepatitis B., Hepatol Int . 2010, 4(4): 716-22.

Fung J.Y.Y., Lai C.L., Wong D.K.H., Seto W.K. and Yuen R.M.F., Significant changes in liver stiffness measurement using transient elastography in hepatitis B patients – 3 year follow-up study. , Hepatology. 2010, 52(4 Suppl): 411A.

Fung J.Y.Y., Lai C.L., Wong D.K.H., Seto W.K., Hung I.F.N. and Yuen R.M.F., Significant changes in liver stiffness measurements in patients with chronic hepatitis B: 3 year follow-up study. [Epub 2011 Jan 7], J Viral Hepat . 2011, 18(7): e200-5.

Fung J.Y.Y., Lai C.L., Wong D.K.H., Seto W.K. and Yuen R.M.F., Switching to lamivudine in entecavir-treated patients with undetectable HBV DNA – final results at 96 weeks., Hepatology. 2010, 52(4 Suppl): 144A.

Fung J.Y.Y., Lai C.L., Seto W.K. and Yuen R.M.F., The use of transient elastography in the management of chronic hepatitis B. [Epub ahead of print], Hepatol Int . 2011.

Fung J.Y.Y., Lai C.L. and Yuen R.M.F., To stop or not to stop: The quest for long-term viral suppression., J Gastroenterol Hepatol . 2011, 26(3): 420-2.

Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Updates in the treatment of chronic hepatitis C., Medical Diary. 2010, 15(12): 12-15.

Seto W.K., Lai C.L., Fung J.Y.Y., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Elevation of ALT fails to predict significant histologic abnormalities in chronic hepatitis B patients. , Hepatol Int . 2011, 5: 164.

Seto W.K., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Hung I.F.N. and Yuen R.M.F., HBV DNA levels after 12 weeks of telbivudine treatment in chronic hepatitis B predicts long-term outcome., Hepatology . 2010, 52(4 Suppl): 143A.

Seto W.K., Lai C.L., Fung J.Y.Y. and Yuen R.M.F., Lamivudine therapy for chronic hepatitis B., Ann Gastroenterol Hepatol. 2010, 1(1): 63-70.

Seto W.K., Lai C.L., Fung J.Y.Y., Hung I.F.N., Yuen J.C.H., Young J.L.P., Wong D.K.H. and Yuen R.M.F., Natural history of chronic hepatitis C: Genotype 1 versus genotype 6, 2010, 53: 444-8.

Seto W.K., Lai C.L., Fung J.Y.Y., Hung I.F.N., Yuen J.C.H., Young J.L.P., Wong D.K.H. and Yuen R.M.F., Natural history of chronic hepatitis C: genotype 1 versus genotype 6., Journal of hepatology : the journal of the European Association for the Study of the Liver. 2010, 53(3): 444-8.

Seto W.K., Lai C.L., Fung J.Y.Y., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Outcome of 4-year tratemnt of entecavir for treatment-naïve chronic hepatitis B - Poster presentation, 46 ^th Annual Meeting of the European Association for the Study of the Liver - The International Liver Congress™ 2011 in Berlin, Germany between March 30 - April 3. 2011, Abstract No. 748.

Seto W.K., Lai C.L., Fung J.Y.Y., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Outcome of 4-year treatment of entecavir for treatment-naive chronic hepatitis B., J Hepatol . 2011, 54: S301.

Seto W.K., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Hung I.F.N. and Yuen R.M.F., Significance of HBV DNA levels at 12 weeks of telbivudine treatment and the 3 years treatment outcome. {Epub ahead of print], J Hepatol. 2010, 55(3): 522-8.

Seto W.K., Yuen R.M.F., Fung J.Y.Y. and Lai C.L., Tenofovir disoproxil fumarate in the treatment of chronic hepatitis B. [Epub ahead of print], Hepatol Int. 2011.

Wong D.K.H., Lai C.L., Seto W.K., Fung J.Y.Y., Huang F.Y., Hung I.F.N. and Yuen R.M.F., Efficacies of one year nucleos(t)ide analogue therapy in intrahepatic HBV DNA and covalently closed circular DNA reduction. , J Hepatol (Poster presentation at the 46th Annual Meeting of EASL, Berlin, March 30 - April 3, 2011).. 2011, 54: S303.

Wong D.K.H., Huang F.Y., Poon R.T.P., Lai C.L., Fung J.Y.Y., Seto W.K., Hung I.F.N. and Yuen R.M.F., HBV replicative activity in patients with cryptogenic cause of hepatocellular carcinoma, Hepatology. 2010, 52: 247A.

Yeung P., Wong D.K.H., Lai C.L., Fung J.Y.Y., Seto W.K. and Yuen R.M.F., Association of Hepatitis B Virus Pre-S Deletions with the Development of Hepatocellular Carcinoma in Chronic Hepatitis B, Journal of Infectious Diseases. 2011, 203: 646-54.

Yeung P., Wong D.K.H., Lai C.L., Fung J.Y.Y., Seto W.K. and Yuen R.M.F., Association of hepatitis B virus pre-S deletions with the development of hepatocellular carcinoma in chronic hepatitis B. 2011;, J Infect Dis . 2011, 203(5): 646-54.

Yeung P., Wong D.K.H., Lai C.L., Fung J.Y.Y., Seto W.K. and Yuen R.M.F., Profile of pre-S deletions in the natural history of chronic hepatitis B infection, Journal of Medical Virology. 2010, 82: 1843-9.

Yeung P., Wong D.K.H., Lai C.L., Fung J.Y.Y., Seto W.K. and Yuen R.M.F., Profile of pre-S deletions in the natural history of chronic hepatitis B. 2010;, J Med Virol . 2010, 82(11): 1843-9.

Yuen R.M.F., Lee C.K., Wong D.K.H., Fung J.Y.Y., Hung I.F.N., Hsu A., But D.Y.K., Cheung T.K., Chan P., Yuen J.C.H., Fung F.K.C., Seto W.K., Lin C.K. and Lai C.L., Prevalence of occult hepatitis B infection in a highly endemicea for chronic hepatitis B: A study of large blood-donor population, GUT. 2010, 59(10): 1389-93.

Yuen R.M.F., Seto W.K., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H. and Lai C.L., Three years of continuous entecavir therapy in treatment-naïve chronic hepatitis B patients: viral suppression, viral resistance and clinical safety. [Epub 2011 Mar 1], Am J Gastroenterol . 2011, 106(7): 1264-71.

Yuen R.M.F., Wong D.K.H., Lee C.K., Tanaka Y., Allain J.P., Fung J.Y.Y., Leung J., Lin C.K., Sugiyama M., Sugauchi F., Mizokami M. and Lai C.L., Transmissibility of hepatitis B virus (HBV) infection through blood transfusion from blood donors with occult hepatitis B virus infection. [Epub 2011 Jan 18], Clin Infect Dis. 2011, 52(5): 624-32.

Researcher : Fung PCW

List of Research Outputs

Shen J., Lee W.S., Gu Y., Fung P.C.W. and Tong L., Ginkgo biloba extract (EGb 761) prevents apoptosis in hypoxia-reoxygenated cardiomyocytes: involvement of mitochondria-dependent caspase pathway, Chiense Medicine. 2011, 6: 8.

Researcher : Fung TK

List of Research Outputs

Chim J.C.S., Wan T.S., Fung T.K. and Wong K.F., Methylation of TET2, CBL and CEBPA in Ph-negative myeloproliferative neoplasms , Journal of Clinical Pathology. 2010, 63(6): 518-21.

Fung T.K., Chung I.S., Liang R.H.S. and Leung A.Y.H., Role of a novel zebrafish nup98 during embryonic development, Experimental Hematology. 2010, Epub.

Researcher : Fung TK

Project Title:	The 52nd ASH Annual Meeting and Exposition Downregulation of SOX7 by DNA Methylation and Its Tumor Suppressing Role In Acute Myeloid Leukemia
Investigator(s):	Fung TK
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	12/2010
Completion Date:	12/2010

List of Research Outputs

Chim J.C.S., Wan T.S., Fung T.K. and Wong K.F., Methylation of TET2, CBL and CEBPA in Ph-negative myeloproliferative neoplasms , Journal of Clinical Pathology. 2010, 63(6): 518-21.

Fung T.K., Chung I.S., Liang R.H.S. and Leung A.Y.H., Role of a novel zebrafish nup98 during embryonic development, Experimental Hematology. 2010, Epub.

Researcher : Gao J

List of Research Outputs

Gao J., Wong W., Mak W. and Cheung R.T.F., An event-related potential study on the information flow during prospective memory interference, Sixteenth Medical Research Conference. 2011, 17 (Suppl 1): 26.

Gao J., Cheung R.T.F., Lee T.M.C., Chu L.W. and Chan Y.S., Task-induced brain deactivation alters the functional connectivity of neural network in aging, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 59-60. 2010.

Gao J., Cheung R.T.F., Lee T.M.C., Chu L.W., Cheung C.M., Fung G., Qiu D.Q. and Chan Y.S., The antero-posterior pattern of white matter decline in normal and abnormal ageing supports retrogenesis: a diffusion tensor imaging study, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 58.. 2010.

Gao J., Cheung R.T.F., Lee T.M.C., Chu L.W. and Chan Y.S., The effect of normal and abnormal ageing on prospective memory showed increased cognitive conflict: a functional MRI study, Sixteenth Medical Research Conference. 2011, 17 (Suppl 1): 51.

Gao J., Cheung R.T.F., Lee T.M.C., Chu L.W. and Chan Y.S., The effect of normal and abnormal ageing on prospective memory showed increased cognitive conflict: a functional MRI study, Hong Kong Medical Journal, 17: 27. [16^th Medical Research Conference. H.K. Jan. 22, 2011]. 2011.

Researcher : Gao J

List of Research Outputs

Gao J., Cheung R.T.F., Lee T.M.C., Chu L.W. and Chan Y.S., The effect of normal and abnormal ageing on prospective memory showed increased cognitive conflict: a functional MRI study, Hong Kong Medical Journal, 17: 27. [16^th Medical Research Conference. H.K. Jan. 22, 2011]. 2011.

Researcher : Gao Y

List of Research Outputs

Li H.Y., Cheung C.L., Xiao S., Lau K.S., Gao Y., Bow C.H.Y., Huang Q.Y., Sham P.C. and Kung A.W.C., Identification Of Qtl Genes For Bmd Variation Using Both Linkage And Gene-based Association Approaches., Human Genetics. 2011.

Xiao S., Gao Y., Cheung C.L., Bow C.H.Y., Lau K.S., Sham P.C., Tan K.C.B. and Kung A.W.C., Association of Cdx1 Binding Site of Periostin Gene with Bone Mineral Density and Vertebral Fracture Risk, The 3rd Joint Meeting of the European Calcified Tissue Society and the International Bone and Mineral Society, 7-11 MAY, Athens, Greece. Athens, Greece, 2011, 7-11 MAY.

Researcher : Ge X

List of Research Outputs

Ge X., Chen C., Hui X., Wang Y., Lam K.S.L. and Xu A., Fibroblast Growth Factor-21 Promotes Glucose Uptake through Activation of the serum response factor (SRF)/ Ets-like protein-1 (Elk-1) signaling cascade in Adipocytes, ADA 2011.

Researcher : Han Q

List of Research Outputs

Han Q., Yeung S.C., Ip M.S.M. and Mak J.C.W., Intermittent hypoxia enhances inflammation and oxidative stress in Eahy926 endothelial cells via suppression of HO-1 expression, American Journal of Respiratory and Critical Care Medicine. 2011, 183: A2475.

Han Q., Yeung S.C., Ip M.S.M. and Mak J.C.W., Intermittent hypoxia enhances oxidative and inflammatory stresses in EAHY926 endothelial cells, Sixth International Symposium of Healthy Aging "A New Golden Age" 5-6 March 2011.

Han Q., Yeung S.C., Ip M.S.M. and Mak J.C.W., Role of HO-1 in intermittent hypoxia-induced inflammation in EAhy926 endothelial cell line, Journal of Pharmacological Sciences. 2011, 115: 158P.

Researcher : He F

List of Research Outputs

He F., Kwong Y.L. and Ho J.C.M., In vitro growth inhibitory effects of arsenic trioxide in non-small cell lung cancer with different K-ras mutations. FEBS Meeting 2010, FEBS Journal. 2010, 277 (suppl 1): 136 (abstract: B2.61).

Researcher : Ho JCM

Project Title:	MERIT – A phase II marker identification trial for TarcevaTM in second line NSCLC patients
Investigator(s):	Ho JCM
Department:	Medicine
Source(s) of Funding:	F Hoffmann-La Roche and Co. Ltd. - General Award
Start Date:	07/2005

Project Title:	A Phase III, radonmized, double-blinded, parallel group, multi centre study to access the efficacy and safety of ZD6474 (ZACTIMA TM) in combination with pemetrexed (Alimta) versus pemetrexed alone in patients with locally-advanced or metastatic (stage IIIB or IV) non-small cell lung cancer (NSCLC) after failure of 1st line anti-cancer therapy
Investigator(s):	Ho JCM, Wong MKY
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	02/2007

Project Title:	A rabdomized, double blind, placebo controlled, phase IIIB trial comparing bevacizumab therapy with or without erlotinib after completion of chemotherapy with bevacizumab for the first line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer
Investigator(s):	Ho JCM
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	08/2007

Project Title:	The effect of inhaled corticosteroids on the risk of diabetes, impaired glucose tolerance and characteristics of glucose regulation in adults with asthma: a population based matched controlled study
Investigator(s):	Ho JCM
Department:	Medicine
Source(s) of Funding:	Lee Wing Tat Fund
Start Date:	08/2007

Project Title:	A Phase 3, multicentre, randomized, placebo-controlled, double-bind trial of AMG 706 in combination with paclitaxel and carboplatin for advanced non-small cell lung cancer
Investigator(s):	Ho JCM
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	11/2007

Project Title:	A phase III, randomized, double-blind, active-controlled, parallel-group study, conducted under in-house building conditions, to examine the safety, tolerability, and efficacy of a single dose of intravenous MK-0517 for the prevention of chemotherapy-induced nausea and vomiting (CINV) associated wtih Cisplatin chemotheray
Investigator(s):	Ho JCM
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	06/2008

Project Title:	A randomized, multicenter phase II study to explore whether biomarkers correlate with treatment outcome in chemo-naive patients with advanced or recurrent non-squamous non-small cell lung cancer, who receive treatment with bevacizumab (at a dose of either 7,5mg.kg or 15mg/kg) in addition to carboplain-based chemotherapy (gemcitabine or paclitaxed)
Investigator(s):	Ho JCM
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	12/2008

Project Title:	In-vitro combination of arsenic trioxide and chemotherapy in non-small cell lung cancer
Investigator(s):	Ho JCM
Department:	Medicine
Source(s) of Funding:	Hong Kong Lung Foundation Research Grant
Start Date:	02/2009

Project Title:	A randomised, placebo-controlled, double-blind phase III study of sequential administration of Tarceva (erlotinib) or placebo in combination with gemcitabine/platinum as first-line treatment in patients with stage IIIB/V non-small cell lung cancer (NSCLC)
Investigator(s):	Ho JCM
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	04/2009

Project Title:	Multicenter, randomized, double-blind, phase III trial to investigate the efficacy and safety of oral BIBF 1120 plus standard pemetrexed therapy compared to placebo plus standard pemetrexed therapy in patients with stage IIIB/IV or recurrent non small cell lung cancer after failure of first line chemotherapy
Investigator(s):	Ho JCM
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	04/2009

Project Title:	A Phase III, multi-center, placebo–controlled trial of Sorafenib (BAY 43-9006) in patients with relapsed or refractory advanced predominantly non squamous Non-Small Cell Lung Cancer (NSCLC) after 2 or 3 previous treatment regimens.
Investigator(s):	Ho JCM, Lam CLD, Lam CM, Wang KLJ, Wong MKY
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	08/2009

Project Title:	In-vitro combination of arsenic trioxide and chemotherapy in non-small cell lung cancer
Investigator(s):	Ho JCM
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	10/2009
Completion Date:	09/2010

Project Title:	Phase 3, randomized, open-label study of the efficacy and safety of PF-02341066 versus standard of care chemotherapy (pemetrexed or docetaxel) in patients with advanced nonsmall cell lung cancer (NSCLC) harbouring a translocation or inversion event involving the anaplastic lymphoma kinase (ALK) gene locus
Investigator(s):	Ho JCM, Lam CLD, Wong MKY, Lam CM, Ip MSM
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	04/2010

Project Title:	Phase 2, open-label single arm study of the efficacy and safety of PF 02341066 in patients with advanced non-small cell lung cancer (NSCLC) harboring a translocation or inversion involving the anaplastic lymphoma kinase (ALK) gene locus
Investigator(s):	Ho JCM, Lam CLD, Wong MKY, Lam CM, Ip MSM
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	04/2010

Project Title:	Study on systemic and airway cytokines and oxidative stress in patients undergoing haemopoietic stem cell transplantation (HSCT)
Investigator(s):	Ho JCM, Lie AKW, Au WY, Liang RHS
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	09/2010

List of Research Outputs

Chan W.M., Lau L.S., Kwok K.M., Law W.L., Ho J.C.M., Chu K.M. and Poon R.T.P., A randomized, double-blind, placebo-controlled, ascending dose infusion trial of the pharmacokinetics of recombinant human gelsolin in patients with decreased natural gelsolin levels. ATS meeting 2011 , American Journal of Respiratory and Critical Care Medicine. 2011, 183: A5601.

He F., Kwong Y.L. and Ho J.C.M., In vitro growth inhibitory effects of arsenic trioxide in non-small cell lung cancer with different K-ras mutations. FEBS Meeting 2010, FEBS Journal. 2010, 277 (suppl 1): 136 (abstract: B2.61).

Ho J.C.M., 1 PDF to support the projects on "Arsenic trioxide in treatment of lung cancer", 24th round PDF/RAP Scheme (Centre for Cancer Reserach) in 2010. 2010.

Ho J.C.M., Highlights on recent advances in treatment of NSCLC, Invited lecture by Roche. Centro Hospitalar Conde S. Januario, Macau. 14 April . 2011.

Ho J.C.M., Low dose CT in the screening of lung cancer, Hong Kong Thoracic Society Annual Scientific Meeting, 27 March, Hong Kong . 2011.

Ho J.C.M., Lung cancer: towards earlier diagnosis and updates on treatment, Certificate course organized by HK College of Family Physicians, 13 November, Hong Kong.. 2010.

Ho J.C.M., Targeted and novel therapy in NSCLC, Annual Scientific Meeting, Hong Kong College of Radiologists, 30 October, Hong Kong.. 2010.

Ho J.C.M., Targeted therapy for NSCLC, Recent advances in the management of lung cancer: symposium and workshop. Division of Respiratory Medicine, Department of Medicine, HKU, 15-16 January. 2011.

Ho J.C.M., Targeted therapy for non-small cell lung cancer, The Hong Kong Medical Diary. 2011, 16(3): 19-21.

Ho J.C.M., Where are we with “maintenance therapy” in NSCLC? In Focus: New Perspectives in NSCLC Management, Hong Kong Lung Cancer Study Group and Hong Kong Society of Clinical Oncology, 5 July.Hong Kong. 2010.

Liao S., Ho J.C.M., Tang F. and O W.S., Adrenomedullin increases ciliary beat frequency and decreases muscular contraction in the rat oviduct, Reproduction. 2011, 141: 367-372.

Researcher : Ho JCY

Project Title:	Differentiation and Isolation of Endothelial Cells from Human Induced Pluripotent Stem Cells
Investigator(s):	Ho JCY, Tse HF, Lai KWH
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	10/2010

List of Research Outputs

Ho J.C.Y., Zhou T., Lai K.W.H., Huang Y., Chan Y.C., Li X., Wong L.Y. .N., Li Y., Au K.W., Guo D., Xu J., Siu D.C.W., Pei D., Tse H.F. and Esteban M.A., Generation of induced pluripotent stem cell lines from 3 distinct laminopathies bearing heterogeneous mutations in lamin A/C., Aging (Albany NY). 2011, 3(4): 380-90.

Li M., Ho J.C.Y., Lai K.W.H., Au K.W., Xu A., Cheung B.M.Y., Lam K.S.L. and Tse H.F., Hypoadiponectinemia and its Impact on circulating endothelial progenitor cells in patients with type 2 diabetes - adiponectin and endothelial progenitor cells, Diabetes/Metab Res Rev. 2010, 27: 185-94.

Li M., Ho J.C.Y., Lai K.W.H., Au K.W., Xu A., Cheung B.M.Y., Lam K.S.L. and Tse H.F., The decrement in circulating endothelial progenitor cells (EPCs) in type 2 diabetes is independent of the severity of the hypoadiponectemia, Diabetes Metab Res Rev. 2011, 27(2): 185-194.

Zhang J., Chan Y.C., Ho J.C.Y., Siu D.C.W., Lian Q. and Tse H.F., Proliferation of Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells via Ether à go-go 1 (hEAG1) Potassium Channel., Journal of Cellular and Molecular Medicine (Under Review). 2011.

Zhou T., Benda C., Duzinger S., Huang Y., Li X., Li Y., Guo X., Cao G., Chen S., Hao L., Chan Y.C., Ng K.M., Ho J.C.Y., Wieser M., Wu J., Redl H., Tse H.F., Grillari J., Grillari-Voglauer R., Pei D. and Esteban M.A., Generation of induced pluripotent stem cells from urine., Journal of the American Society of Nephrology. 2011.

Researcher : Ho SL

Project Title:	Biochemical markers in a large Chinese kindred with autosomal dominant motor neurone disease associated with SOD1 mutation
Investigator(s):	Ho SL, Song Y, Wang Y
Department:	Medicine
Source(s) of Funding:	Liu Po Shan/Dr Vincent Liu Endowment Fund for Motor Neuron diseases - General Award
Start Date:	04/2007

Project Title:	The role of neuronal uncoupling proteins (UCPs) in mitochondrial dysfunction in Parkinson's disease (PD)
Investigator(s):	Ho SL, Ho WL
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2007
Completion Date:	08/2010

List of Research Outputs

Chan K.H., Kwan S.C., Ho W.L., Ho S.L., Chui W.H., Chu A.C.Y., Ho W.M., Zhang W.Y. and Kung M.H.W., Aquaporin-4 water channel expression by thymoma of patients with and without myasthenia gravis, Journal of Neuroimmunology. 2010, 227: 178-184.

Chang R.S.K., Mak W., Cheung R.T.F. and Ho S.L., Risk factors, clinical presentation and prognosis of perioperative stroke: a retrospective case-control study, 63rd Annual Meeting of the American Academy of Neurology. 2011, 76 (Suppl 4): A60.

Ho S.L., , In: Invited Chairperson, Asian Scientific Symposium on Parkinson’s disease and Restless Legs syndrome, Tokyo, Japan. Tokyo, Japan, 2010.

Ho S.L., Editorial Board Member, Brain and Behavior. USA, Wiley Publishers Inc, USA, 2011.

Ho S.L., Loong F., Lam C.C.K., Anthony M. and Kwong Y.L., F-18 Fluorodeoxyglucose non-avid hepatosplenic T cell lymphoma: a diagnostic pitfall., Ann Hematol.. 2011.

Ho S.L., Invited Speaker. Asian Oceanian Section Educational Course on Movement Disorders. , Movement Disorder Society, Guwahati, India . 2011.

Ho S.L., Invited Speaker. “Novel approaches to treatment of Parkinson’s disease.” and “Rationale for the use of dopamine agonists in Parkinson’s disease”, 3rd Asian & Oceanian Parkinson’s Disease & Movement Disorders Congress (AOPMC), Taipei, Taiwan. 2011.

Ho S.L., Invited Speaker. “Treatment of advanced Parkinson’s disease”, Japanese Neurological Society Annual Meeting, Nagoya, Japan. 2011.

Ho W.L., Ho W.M., Liu H., So H.F., Chan K.H., Ramsden D.B. and Ho S.L., Functional studies of neuronal mitochondrial uncoupling proteins: implication in the pathology of Parkinson’s disease, The Hong Kong Neurological Society - Annual Scientific Meeting 2010; Kowloon Shangri-La Hotel, Hong Kong; 2010.. 2010.

Ho W.L., Ho W.M., So H.F., Liu H., Chan K.H., Ramsden D.B. and Ho S.L., Manipulation of mitochondria functions via uncoupling proteins as novel strategy against energy deficiency and neurodegeneration, Croucher Advanced Study Institute on Mitochondrial Stress in Diabetes and Aging, 29 April, 2011, organized by the Croucher Foundation; HBHA, University of Hong Kong.. 2011.

Ho W.L., Ho W.M., So H.F., Liu H., Chan K.H., Ramsden D.B. and Ho S.L., Potential role of mitochondrial uncoupling protein-4 (UCP4) in energy supply during neuronal differentiation , 16th Medical Research Conference 2011, University of Hong Kong. 2011, 17(1): suppl 1;: 31.

Ho W.L., Ho W.M., Zhang W., Yiu C.W., Liu H., Chan K.H., Ramsden D.B. and Ho S.L., Role of mitochondrial uncoupling protein-4 (UCP4) in energy supply during neuronal differentiation, EMBO Meeting 2010, Barcelona, Spain. 2010.

Ho W.M., Ho W.L., Zhang W., Liu H., Kwok H.H., Yiu C.W., Chan K.H., Kung M.H.W., Ramsden D.B. and Ho S.L., Activation of c-Rel mediates neuroprotection via mitochondrial uncoupling protein-4 under NF-kB pathways, EMBO Meeting 2010, Barcelona, Spain (4-7 Sept, 2010). 2010.

Kwan M.W., Mak W., Cheung R.T.F. and Ho S.L., Ischemic stroke related to intracranial branch atheromatous disease and comparison with large and small artery diseases, J Neurol Sci. . J Neurol Sci., 2011, 303(1-2):: 80-4.

Pang S.Y.Y., Lee C.N., Tsoi T.H., Yip K.K., Chan K.H., Kung M.H.W. and Ho S.L., Transient axonal glycoprotein-1 (TAG-1) polymorphism and its correlation with clinical features and prognosis in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), 63rd American Academy of Neurology Annual Meeting 2011, Honlolulu,Hawaii; Neurology. 2011, 76 (Suppl 4): A570.

Tse C.T., Chung C.P., Tse M.M.Y., Ho S.L., Cheung K.S., Kwan S.C., Ho W.L., Ho W.M. and Chan K.H., Cerebral involvement in neuromyelitis optica spectrum disorders among Hong Kong Chinese, 16th Medical Research Conference, Department of Medicine, The University of Hong Kong, 2011. Hong Kong Medical Journal. 2011, 17 (Supplement 1): 55.

Researcher : Ho WL

Project Title:	Identification and characterization of the promoter region of human neuronal uncoupling protein-4, and its regulation to neuroprotection
Investigator(s):	Ho WL, Ho SL, Chan KH
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2009
Completion Date:	01/2011

Project Title:	Development of a novel human catechol-O-methyltransferase (COMT) assay to detect estrogenic inhibitors and inducers
Investigator(s):	Ho WL, Ho SL
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2010

Project Title:	The EMBO Meeting 2010 Role of mitochondrial uncoupling protein-4 (UCP4) in energy supply during neuronal differentiation
Investigator(s):	Ho WL
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	09/2010
Completion Date:	09/2010

Project Title:	Pathological role of R1441G mutant leucine-rich repeat kinase 2 (LRRK2) in ubiquitin-proteasomal system and mitochondrial autophagy in Parkinson's disease
Investigator(s):	Ho WL, Ho SL, Chan KH
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2011

List of Research Outputs

Chan K.H., Kwan S.C., Ho W.L., Ho W.M. and Ramsden D.B., Aquaporin-4 autoantibodies in neuromyelitis optica spectrum disorders: comparison between tissue-based and cell-based indirect immunofluorescence assays, 15th Research Postgraduate Symposium, LKS Faculty of Medicine, the University of Hong Kong. 2010.

Chan K.H., Kwan S.C., Ho W.L., Ho W.M., Chu A.C.Y. and Ramsden D.B., Aquaporin-4 autoantibodies in neuromyelitis optica spectrum disorders: comparison between tissue-based and cell-based indirect immunofluorescence assays, Journal of Neuroinflammation. 2010, 7(1): 50.

Chan K.H., Kwan S.C., Ho W.L., Ho S.L., Chui W.H., Chu A.C.Y., Ho W.M., Zhang W.Y. and Kung M.H.W., Aquaporin-4 water channel expression by thymoma of patients with and without myasthenia gravis, Journal of Neuroimmunology. 2010, 227: 178-184.

Chan K.H., Tse C. .T., Chung C.P., Lee R., Kwan S.C., Ho W.L. and Ho W.M., Brain Involvement In Neuromyelitis Optica Spectrum Disorders, Archives of Neurology. 2011, 68(11): 1432-1439.

Chan K.H., Kwan S.C., Zhang R., Ho W.L. and Ho W.M., Passive transfer of IgG from aquaporin-4 autoantibodies seropositive neuromyelitis optica patients to mice cause spinal cord aquaporin-4 loss without myelitis, 63rd American Academy of Neurology Annual Meeting, Neurology. 2011, 76 (Supplement 4): A537-538.

Ho W.L., Ho W.M., Liu H., So H.F., Chan K.H., Ramsden D.B. and Ho S.L., Functional studies of neuronal mitochondrial uncoupling proteins: implication in the pathology of Parkinson’s disease, The Hong Kong Neurological Society - Annual Scientific Meeting 2010; Kowloon Shangri-La Hotel, Hong Kong; 2010.. 2010.

Ho W.L., Ho W.M., So H.F., Liu H., Chan K.H., Ramsden D.B. and Ho S.L., Manipulation of mitochondria functions via uncoupling proteins as novel strategy against energy deficiency and neurodegeneration, Croucher Advanced Study Institute on Mitochondrial Stress in Diabetes and Aging, 29 April, 2011, organized by the Croucher Foundation; HBHA, University of Hong Kong.. 2011.

Ho W.L., Ho W.M., So H.F., Liu H., Chan K.H., Ramsden D.B. and Ho S.L., Potential role of mitochondrial uncoupling protein-4 (UCP4) in energy supply during neuronal differentiation , 16th Medical Research Conference 2011, University of Hong Kong. 2011, 17(1): suppl 1;: 31.

Ho W.L., Ho W.M., Zhang W., Yiu C.W., Liu H., Chan K.H., Ramsden D.B. and Ho S.L., Role of mitochondrial uncoupling protein-4 (UCP4) in energy supply during neuronal differentiation, EMBO Meeting 2010, Barcelona, Spain. 2010.

Ho W.M., Ho W.L., Zhang W., Liu H., Kwok H.H., Yiu C.W., Chan K.H., Kung M.H.W., Ramsden D.B. and Ho S.L., Activation of c-Rel mediates neuroprotection via mitochondrial uncoupling protein-4 under NF-kB pathways, EMBO Meeting 2010, Barcelona, Spain (4-7 Sept, 2010). 2010.

Tse C.T., Chung C.P., Tse M.M.Y., Ho S.L., Cheung K.S., Kwan S.C., Ho W.L., Ho W.M. and Chan K.H., Cerebral involvement in neuromyelitis optica spectrum disorders among Hong Kong Chinese, 16th Medical Research Conference, Department of Medicine, The University of Hong Kong, 2011. Hong Kong Medical Journal. 2011, 17 (Supplement 1): 55.

Tse C.T., Lee R., Kwan S.C., Ho W.L., Ho W.M. and Chan K.H., Cerebral involvement in neuromyelitis optica spectrum disorders with aquaporin-4 autoimmunity, Sixth International Symposium On Healthy Aging. 2011.

Zhou L., Chu L.W., Kwan S.C., Lam K.S.L., Ho W.L., Ho W.M. and Chan K.H., Plasma amyloid beta peptides and oligomers antibodies in Alzheimer's disease, 16th Medical Research Conference, Department of Medicine, The University of Hong Kong, 2011. Hong Kong Medical Journal . 2011, 17 (Supplement 1): 69.

Zhou L., Chu L.W., Kwan S.C., Lam K.S.L., Ho W.L., Ho W.M. and Chan K.H., Plasma amyloid beta peptides and oligomers levels in Alzheimer's disease, 16th Medical Research Conference, Department of Medicine, The University of Hong Kong, 2011. Hong Kong Medical Journal. 2011, 17 (Supplement 1): 69.

Zhou L., Chu L.W., Kwan S.C., Lam K.S.L., Ho W.L., Ho W.M. and Chan K.H., Plasma beta-amyloid peptides and serum associated beta-amyloid autoantibodies in patients with Alzheimer's disease, Alzheimer's Disease Conference 2011: From Public Health, Basci And Clinical Sciences To Therapeutic Insights. 2011.

Zhou L., Chu L.W., Kwan S.C., Lam K.S.L., Ho W.L., Ho W.M. and Chan K.H., Plasma b-amyloid Peptides And Serum Associated b-amyloid Autoantibodies In Alzheimer's Disease, Sixth International Symposium On Healthy Aging. 2011.

Researcher : Ho WM

List of Research Outputs

Chan K.H., Kwan S.C., Ho W.L., Ho W.M. and Ramsden D.B., Aquaporin-4 autoantibodies in neuromyelitis optica spectrum disorders: comparison between tissue-based and cell-based indirect immunofluorescence assays, 15th Research Postgraduate Symposium, LKS Faculty of Medicine, the University of Hong Kong. 2010.

Chan K.H., Kwan S.C., Ho W.L., Ho W.M., Chu A.C.Y. and Ramsden D.B., Aquaporin-4 autoantibodies in neuromyelitis optica spectrum disorders: comparison between tissue-based and cell-based indirect immunofluorescence assays, Journal of Neuroinflammation. 2010, 7(1): 50.

Chan K.H., Kwan S.C., Ho W.L., Ho S.L., Chui W.H., Chu A.C.Y., Ho W.M., Zhang W.Y. and Kung M.H.W., Aquaporin-4 water channel expression by thymoma of patients with and without myasthenia gravis, Journal of Neuroimmunology. 2010, 227: 178-184.

Chan K.H., Tse C. .T., Chung C.P., Lee R., Kwan S.C., Ho W.L. and Ho W.M., Brain Involvement In Neuromyelitis Optica Spectrum Disorders, Archives of Neurology. 2011, 68(11): 1432-1439.

Chan K.H., Kwan S.C., Zhang R., Ho W.L. and Ho W.M., Passive transfer of IgG from aquaporin-4 autoantibodies seropositive neuromyelitis optica patients to mice cause spinal cord aquaporin-4 loss without myelitis, 63rd American Academy of Neurology Annual Meeting, Neurology. 2011, 76 (Supplement 4): A537-538.

Ho W.L., Ho W.M., Liu H., So H.F., Chan K.H., Ramsden D.B. and Ho S.L., Functional studies of neuronal mitochondrial uncoupling proteins: implication in the pathology of Parkinson’s disease, The Hong Kong Neurological Society - Annual Scientific Meeting 2010; Kowloon Shangri-La Hotel, Hong Kong; 2010.. 2010.

Ho W.L., Ho W.M., So H.F., Liu H., Chan K.H., Ramsden D.B. and Ho S.L., Manipulation of mitochondria functions via uncoupling proteins as novel strategy against energy deficiency and neurodegeneration, Croucher Advanced Study Institute on Mitochondrial Stress in Diabetes and Aging, 29 April, 2011, organized by the Croucher Foundation; HBHA, University of Hong Kong.. 2011.

Ho W.L., Ho W.M., So H.F., Liu H., Chan K.H., Ramsden D.B. and Ho S.L., Potential role of mitochondrial uncoupling protein-4 (UCP4) in energy supply during neuronal differentiation , 16th Medical Research Conference 2011, University of Hong Kong. 2011, 17(1): suppl 1;: 31.

Ho W.L., Ho W.M., Zhang W., Yiu C.W., Liu H., Chan K.H., Ramsden D.B. and Ho S.L., Role of mitochondrial uncoupling protein-4 (UCP4) in energy supply during neuronal differentiation, EMBO Meeting 2010, Barcelona, Spain. 2010.

Ho W.M., Ho W.L., Zhang W., Liu H., Kwok H.H., Yiu C.W., Chan K.H., Kung M.H.W., Ramsden D.B. and Ho S.L., Activation of c-Rel mediates neuroprotection via mitochondrial uncoupling protein-4 under NF-kB pathways, EMBO Meeting 2010, Barcelona, Spain (4-7 Sept, 2010). 2010.

Tse C.T., Chung C.P., Tse M.M.Y., Ho S.L., Cheung K.S., Kwan S.C., Ho W.L., Ho W.M. and Chan K.H., Cerebral involvement in neuromyelitis optica spectrum disorders among Hong Kong Chinese, 16th Medical Research Conference, Department of Medicine, The University of Hong Kong, 2011. Hong Kong Medical Journal. 2011, 17 (Supplement 1): 55.

Tse C.T., Lee R., Kwan S.C., Ho W.L., Ho W.M. and Chan K.H., Cerebral involvement in neuromyelitis optica spectrum disorders with aquaporin-4 autoimmunity, Sixth International Symposium On Healthy Aging. 2011.

Zhou L., Chu L.W., Kwan S.C., Lam K.S.L., Ho W.L., Ho W.M. and Chan K.H., Plasma amyloid beta peptides and oligomers antibodies in Alzheimer's disease, 16th Medical Research Conference, Department of Medicine, The University of Hong Kong, 2011. Hong Kong Medical Journal . 2011, 17 (Supplement 1): 69.

Zhou L., Chu L.W., Kwan S.C., Lam K.S.L., Ho W.L., Ho W.M. and Chan K.H., Plasma amyloid beta peptides and oligomers levels in Alzheimer's disease, 16th Medical Research Conference, Department of Medicine, The University of Hong Kong, 2011. Hong Kong Medical Journal. 2011, 17 (Supplement 1): 69.

Zhou L., Chu L.W., Kwan S.C., Lam K.S.L., Ho W.L., Ho W.M. and Chan K.H., Plasma beta-amyloid peptides and serum associated beta-amyloid autoantibodies in patients with Alzheimer's disease, Alzheimer's Disease Conference 2011: From Public Health, Basci And Clinical Sciences To Therapeutic Insights. 2011.

Zhou L., Chu L.W., Kwan S.C., Lam K.S.L., Ho W.L., Ho W.M. and Chan K.H., Plasma b-amyloid Peptides And Serum Associated b-amyloid Autoantibodies In Alzheimer's Disease, Sixth International Symposium On Healthy Aging. 2011.

Researcher : Ho WM

List of Research Outputs

Chan K.H., Tse C. .T., Chung C.P., Lee R., Kwan S.C., Ho W.L. and Ho W.M., Brain Involvement In Neuromyelitis Optica Spectrum Disorders, Archives of Neurology. 2011, 68(11): 1432-1439.

Researcher : Hoo RLC

Project Title:	The role of adipocyte fatty acid binding protein in association with autophagy in lipids-induced endoplasmic reticulum stress
Investigator(s):	Hoo RLC, Lam KSL, Xu A
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2011

List of Research Outputs

Chang J., Li Y., Huang Y., Lam K.S.L., Hoo R.L.C., Wong W.T., Cheng K.Y., Wang Y., Vanhoutte P.M.G.R. and Xu A., Adiponectin prevents diabetic premature senescence of endothelial progenitor cells and promotes endothelial repair by suppressing the p38 MAP kinase/p16INK4A signaling pathway, Diabetes. 2010, 59: 2949-59.

Cheng K.Y., Lam K.S.L., Wang Y., Zhu W., Hoo R.L.C. and Xu A., Transgenic over-expression of APPL1 improves high-fat diet-induced insulin resistance in liver and skeletal muscle., Sixth International Symposium on Healthy Aging: " A New Golden Age”. 2011.. 2011.

Hoo R.L.C., Chu J.Y.S., Yuan Y., Yeung C.M., Chan K.Y.Y. and Chow B.K.C., Functional identification of an intronic promoter of the human glucose-dependent insulinotropic polypeptide gene , Gene. 2010, 463: 29-40.

Hoo R.L.C., Wong Y.L., Xu A. and Lam K.S.L., The role of fatty acid binding protein in the pathogenesis of obesity-related inflammatory diseases, Research centre of heart, brain and healthy aging. 2011.

Hoo R.L.C., Wong Y.L., Qiao C.F., Xu A., Xu H.X. and Lam K.S.L., he effective fraction isolated from Radix Astragali alleviates glucose intolerance, insulin resistance and hypertriglyceridemia in db/db diabetic mice through its anti-inflammatory activity, Nutr Metab. 2010, 7: 67.

Lam K.S.L., Hoo R.L.C., Wong Y.L. and Xu A., Adipocyte fatty acid binding protein in Kupffer cell mediates non alcoholic fatty liver disease through endoplasmic reticulum stresss and inflammation, Endocrine society meeting 2011.

Li F.Y.L., Hoo R.L.C., Lam K.S.L. and Xu A., Outstanding Scientific Work – Winning poster presentation , Frontiers in Cardiovascular Biology; European Society of Cardiology. 2010.

Li F.Y.L., Hoo R.L.C., Lam K.S.L. and Xu A., Toll-like receptor 4 inactivation alleviates impaired vascular reendothelialisation by improving endothelial progenitor cell adhesion, In: Hans Michael Piper, Journal of Cardiovascular Research. United Kingdom, Oxford Journals, 2010, 87: S48.

Researcher : Hsu ASJ

List of Research Outputs

Fung J.Y.Y., Lai C.L., But D.Y.K., Hsu A.S.J., Seto W.K., Cheng C.T.K., Wong D.K.H. and Yuen R.M.F., Reduction of liver stiffness following resolution of acute flares of chronic hepatitis B., Hepatol Int . 2010, 4(4): 716-22.

Hsu A.S.J., Lai C.L. and Yuen R.M.F., Update on risk of hepatocellular carcinoma in chronic hepatitis B virus infection. 2011;., Current Hepatitis Reports. 2011, 10(2): 106-111.

Researcher : Hu HC

Project Title:	A study to validate a symptom severity questionnaire for patents with functional dyspepsia
Investigator(s):	Hu HC, Lam CLK
Department:	Medicine
Source(s) of Funding:	Health Services Research Fund - Full Grants
Start Date:	10/1998

Researcher : Huang FY

Project Title:	Role of estrogen in regulating inflammatory gene expression and hepatocarcinogenesis
Investigator(s):	Huang FY, Lai CL, Yuen RMF, Wong DKH
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2010

List of Research Outputs

Wong D.K.H., Lai C.L., Seto W.K., Fung J.Y.Y., Huang F.Y., Hung I.F.N. and Yuen R.M.F., Efficacies of one year nucleos(t)ide analogue therapy in intrahepatic HBV DNA and covalently closed circular DNA reduction. , J Hepatol (Poster presentation at the 46th Annual Meeting of EASL, Berlin, March 30 - April 3, 2011).. 2011, 54: S303.

Wong D.K.H., Huang F.Y., Poon R.T.P., Lai C.L., Fung J.Y.Y., Seto W.K., Hung I.F.N. and Yuen R.M.F., HBV replicative activity in patients with cryptogenic cause of hepatocellular carcinoma, Hepatology. 2010, 52: 247A.

Researcher : Huang Q

Project Title:	Large scale association studies of osteoporosis in Chinese
Investigator(s):	Huang Q, Kung AWC, Sham PC
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2009
Completion Date:	12/2010

Researcher : Hui CK

Project Title:	Significance of occult hepatitis B infection in patients undergoing autologous HSCT
Investigator(s):	Hui CK, Liang RHS, Lau G, Lie AKW
Department:	Medicine
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	10/2006

Researcher : Hui X

List of Research Outputs

Gao X., Li K., Hui X., Kong X., Sweeney G., Wang Y., Xu A., Teng M., Liu P. and Wu D., Carnitine palmitoyltransferase 1A prevents fatty acid-induced adipocyte dysfunction through suppression of c-Jun N-terminal kinase, Biochem J. 2011, 435(3): 723-32.

Ge X., Chen C., Hui X., Wang Y., Lam K.S.L. and Xu A., Fibroblast Growth Factor-21 Promotes Glucose Uptake through Activation of the serum response factor (SRF)/ Ets-like protein-1 (Elk-1) signaling cascade in Adipocytes, ADA 2011.

Liu X., Huang X., Lin W., Wang D., Diao Y., Li H., Hui X., Wang Y., Xu A., Wu D. and Ke D., New aromatic substituted pyrazoles as selective inhibitors of human adipocyte fatty acid-binding protein, Bioorg Med Chem Lett. 2011, 21(10): 2949-52.

Researcher : Hung I.F.N.

Project Title:	Harvesting convalescent plasma for hyperimmune intravenous globulin production: a multicentres, randomised double-blind controlled trial for treatment of patients with serious S-OIV H1N1 infection
Investigator(s):	Hung IFN, Chan KH, Liang RHS, Lai ST, Yuen KY
Department:	Medicine
Source(s) of Funding:	Commissioned Studies on Human Swine Influenza Research
Start Date:	08/2009

List of Research Outputs

Cheung B...M...Y..., Hung I...F...N... and Wong S...Y..., Proton Pump Inhibitors - a Sting in the Tale?, The Hong Kong Medical Daily. 2010, 15: 4-5.

Hung I...F...N..., Current Application of Spiral Enteroscopy, Taiwan Medical Week 2010, Formosan Medical Association, Taipei, Taiwan, 12-14 November 2010. 2010.

Hung I...F...N... and Yuen K...Y..., Reply to Lee et al, Clinical Infectious Diseases. 2011, 52(4): 559.

Hung I...F...N..., Update on Small Bowel Examination, Recent advances in Endoscopy 2011, The University of Hong Kong and The Hospital Authority . 2011.

Zhang W..., Wang J..., Zou B..., Sardet C..., Li J..., Lam S...C..., Ng L..., Pang R...W...C..., Hung I...F...N..., Tan V...P...Y..., Jiang B... and Wong B...C...Y..., Four and a half LIM protein 2 (FHL2) negatively regulates the transcription of E-cadherin through interaction with Snail1, European Journal of Cancer. 2011, 47(1): 121-130.

Zhang W..., Yang Y..., Jiang B..., Peng J., Tu S..., Sardet C..., Zhang Y..., Pang R...W...C..., Hung I...F...N..., Tan V...P...Y..., Lam S...C..., Wang J... and Wong B...C...Y..., XIAP-associated factor 1 interacts with and attenuates the trans-activity of four and a half LIM protein 2, Molecular Carcinogenesis. 2010, 50: 199-207.

Researcher : Hung IFN

Project Title:	Harvesting convalescent plasma for hyperimmune intravenous globulin production: a multicentres, randomised double-blind controlled trial for treatment of patients with serious S-OIV H1N1 infection
Investigator(s):	Hung IFN, Chan KH, Liang RHS, Lai ST, Yuen KY
Department:	Medicine
Source(s) of Funding:	Commissioned Studies on Human Swine Influenza Research
Start Date:	08/2009

List of Research Outputs

Cheng V.C.C., Wong L.M., Tai J.W., Chan J.F.W., To K.K.W., Li W.S., Hung I.F.N., Chan K.H., Ho P.L. and Yuen K.Y., Prevention of nosocomial transmission of norovirus by strategic infection control measures, Infection control and hospital epidemiology. 2011, 32(3): 229-37.

Fung J.Y.Y., Lai C.L., Yuen J.C.H., Cheng C.T.K., Wu C.H., Wong D.K.H., Seto W.K., Hung I.F.N. and Yuen R.M.F., Randomized trial of lamivudine versus entecavir in entecavir-treated patients with undetectable hepatitis B virus DNA: Outcome at 2 years., Hepatology. 2011, 53(4): 1148-53.

Fung J.Y.Y., Lai C.L., Wong D.K.H., Seto W.K., Hung I.F.N. and Yuen R.M.F., Significant changes in liver stiffness measurements in patients with chronic hepatitis B: 3 year follow-up study. [Epub 2011 Jan 7], J Viral Hepat . 2011, 18(7): e200-5.

Hung I.F.N., Clinical Presentation, Immune Response & Management of Pandemic (H1N1) 2009 Influenza, In: The Lancet, CDC, International Forum on Pandemic Influenza 2010, Qingdao, China. 2010.

Hung I.F.N., To K.K.W., Lee C...K..., Lee K...L..., Chan K..., Yan W...W..., Liu R..., Watt C...L..., Chan W.M., Lai K...Y..., Koo C...K..., Buckley T..., Chow F...L..., Wong K...K..., Chan H...S..., Ching C...K..., Tang B...S...F..., Lau C.Y., Li W.S., Liu S...H..., Chan K.H., Lin C...K... and Yuen K.Y., Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A (H1N1) 2009 virus infection , Clinical Infectious Diseases. 2011, 52(4): 447-456.

Hung I.F.N., To K.K.W., Lee C.K., Lin C.K., Chan J.F.W., Tse H., Cheng V.C.C., Chen H., Ho P.L., Tse C.W.S., Ng T.K., Que T.L., Chan K.H. and Yuen K.Y., Effect of clinical and virological parameters on the level of neutralizing antibody against pandemic influenza A virus H1N1 2009., Clinical Infectious Disease. 2010, 51: 274-9.

Hung I.F.N., Leung A.Y.M., Chu D.W.S., Leung Y.P., Cheung T..., Chan C.K., Lam C.L.K., Liu S...H..., Chu C...M..., Ho P.L., Chan S.S.C., Lam T.H., Liang R.H.S. and Yuen K.Y., Prevention of acute myocardial infarction and stroke among elderly persons by dual pneumococcal and influenza vaccination: a prospective cohort study, Clinical Infectious Diseases. 2010, 51(9): 1007-1016.

Ma J., Wang J., Zhang W., Zou B., Chen W., Lam S.C., Chen M., Pang R.W.C., Tan V.P.Y., Hung I.F.N., Lan H.Y., Wang Q. and Wong B.C.Y., Promoter hypermethylation and histone hypoacetylation contribute to Pancreatic-duodenal homeobox 1 (PDX1) silencing in gastric cancer., Carcinogenesis. 2010, 31(9): 1552-60.

Seto W.K., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Hung I.F.N. and Yuen R.M.F., HBV DNA levels after 12 weeks of telbivudine treatment in chronic hepatitis B predicts long-term outcome., Hepatology . 2010, 52(4 Suppl): 143A.

Seto W.K., Ng M.M.T., Chan P., Ng I.O.L., Cheung S.C.W., Hung I.F.N., Yuen R.M.F. and Lai C.L., Ketamine-induced cholangiopathy: a case report., Am J Gastroenterol. 2011, 106(5): 1004-5.

Seto W.K., Lai C.L., Fung J.Y.Y., Hung I.F.N., Yuen J.C.H., Young J.L.P., Wong D.K.H. and Yuen R.M.F., Natural history of chronic hepatitis C: Genotype 1 versus genotype 6, 2010, 53: 444-8.

Seto W.K., Lai C.L., Fung J.Y.Y., Hung I.F.N., Yuen J.C.H., Young J.L.P., Wong D.K.H. and Yuen R.M.F., Natural history of chronic hepatitis C: genotype 1 versus genotype 6., Journal of hepatology : the journal of the European Association for the Study of the Liver. 2010, 53(3): 444-8.

Seto W.K., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Hung I.F.N. and Yuen R.M.F., Significance of HBV DNA levels at 12 weeks of telbivudine treatment and the 3 years treatment outcome. {Epub ahead of print], J Hepatol. 2010, 55(3): 522-8.

To K.K.W., Wong S.S.Y., Li W.S., Hung I.F.N., Tse H., Woo P.C.Y., Chan K.H. and Yuen K.Y., Concurrent comparison of epidemiology, clinical presentation and outcome between adult patients suffering from the pandemic influenza A (H1N1) 2009 virus and seasonal influenza A virus infection, Postgrad Med J. 2010.

To K.K.W., Hung I.F.N. and Yuen K.Y., Intradermal 2009 Pandemic Influenza A(H1N1) Vaccination as a Strategy for Dose and Adjuvant Sparing , Infectious Diseases Society of America 48th Annual Meeting. 2010.

Wong D.K.H., Lai C.L., Seto W.K., Fung J.Y.Y., Huang F.Y., Hung I.F.N. and Yuen R.M.F., Efficacies of one year nucleos(t)ide analogue therapy in intrahepatic HBV DNA and covalently closed circular DNA reduction. , J Hepatol (Poster presentation at the 46th Annual Meeting of EASL, Berlin, March 30 - April 3, 2011).. 2011, 54: S303.

Wong D.K.H., Huang F.Y., Poon R.T.P., Lai C.L., Fung J.Y.Y., Seto W.K., Hung I.F.N. and Yuen R.M.F., HBV replicative activity in patients with cryptogenic cause of hepatocellular carcinoma, Hepatology. 2010, 52: 247A.

Wu J.T.K., Ma S.K., Lee C.K., Chu K.W., Ho P.L., Shen L., Ho W.K., Hung I.F.N., Riley S., Ho L.M., Lin C.K., Tsang T.H.F., Lo S.V., Lau Y.L., Leung G.M., Cowling B.J. and Peiris J.S.M., A serial cross-sectional serologic survey of 2009 Pandemic (H1N1) in Hong Kong: implications for future pandemic influenza surveillance (Options for the Control of Influenza VII, 3-7 September 2010, Hong Kong), Influenza and Other Respiratory Viruses. 2011, 5(Suppl 1): 190-194.

Wu J.T.K., Cowling B.J., Riley S., Peiris J.S.M., Ma E., Lee K., Hung I.F.N., Lau Y.L., Lo S.V. and Leung G.M., A serial cross-sectional serologic survey of 2009 pandemic (H1N1) in Hong Kong: Implications for future pandemic influenza surveillance (abstract), Options for the Control of Influenza VII Conference, 3-7 September 2010, Hong Kong. Hong Kong, Int’l Society for Influenza & Other Respiratory Virus Dis, 2010, 256.

Yip T.P.S., Tse K.C., Ng F.S.K., Hung I.F.N., Lam M.F., Tang S.C.W., Lui S.L., Lai K.N., Chan D.T.M. and Lo W.K., Clinical course and outcomes of single-organism Enterococcus peritonitis in dialysis patients, Peritoneal Dialysis International. 2011, 31.

Yuen R.M.F., Lee C.K., Wong D.K.H., Fung J.Y.Y., Hung I.F.N., Hsu A., But D.Y.K., Cheung T.K., Chan P., Yuen J.C.H., Fung F.K.C., Seto W.K., Lin C.K. and Lai C.L., Prevalence of occult hepatitis B infection in a highly endemicea for chronic hepatitis B: A study of large blood-donor population, GUT. 2010, 59(10): 1389-93.

Zhang W., Jiang B., Guo Z., Sardet C., Zou B., Lam S.C., Li J., He M., Lan H.Y., Pang R.W.C., Hung I.F.N., Tan V.P.Y., Wang J. and Wong B.C.Y., Four-and-a-half LIM protein 2 promotes invasive potential and epithelial-mesenchymal transition in colon cancer., Carcinogenesis. 2010, 31: 1220-9.

Zou B., Chim J.C.S., Pang R.W.C., Zeng H.U.I., Dai Y., Zhang R., Lam S.C., Tan V.P.Y., Hung I.F.N. and Lan H.Y., XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification, Mol Carcinog. 2011.

Zou B., Chim J.C.S., Pang R.W.C., Zeng H.U.I., Dai Y., Zhang R., Lam S.C., Tan V.P.Y., Hung I.F.N., Lan H.Y. and Wong B.C.Y., XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification, Molecular Carcinogenesis. 2010, under review.

Researcher : Ip MSM

Project Title:	The efficacy of the modified oral appliance in the treatment of mild and moderate obstructive Sleep Apnoea
Investigator(s):	Ip MSM
Department:	Medicine
Source(s) of Funding:	Other Funding Scheme
Start Date:	02/1997

Project Title:	The effect of oral appliance (OA) in treatment of obstructive sleep apnoea
Investigator(s):	Ip MSM, Peh WCG, Cooke MS
Department:	Medicine
Source(s) of Funding:	Other Funding Scheme
Start Date:	06/1997

Project Title:	Role of adiponectin in obstructive sleep apnoea
Investigator(s):	Ip MSM, Lam KSL
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Project Title:	Candidate genes of obstructive sleep apnoea syndrome in Hong Kong Chinese
Investigator(s):	Ip MSM, Lam KSL, Song Y, Sham PC, Lam CL
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2005

List of Research Outputs

Chan C.H., Leung V.O.Y., Lam C.L.D., Mak J.C.W., Ip M.S.M., Freeman C. and Shum D.K.Y., Sulfated maltoheptaose is a potential therapeutic in reducing neutrophilic inflammation in a cigarette smoke-induced rat model of chronic obstructive pulmonary disease, American Society for Matrix Biology, 2010 Meeting, Charlecton, SC, USA. Oct 24-27. 2010.

Chan C.H., Lam C.L.D., Mak J.C.W., Ip M.S.M., Freeman C. and Shum D.K.Y., Use of sulfated maltoheptaose to lower neutrophilic inflammation in a rat model of cigarette smoke-induced chronic obstructive pulmonary disease , Sixth International Symposium on Healthy Aging: “A New Golden Age” 5-6 March . 2011.

Chan K.H., Yeung S.C., Yao T., Ip M.S.M., Cheung A.H.K., Chan M.M.W. and Mak J.C.W., Elevated Plasma Adiponectin Levels In Patients With Chronic Obstructive Pulmonary Disease, Internatioanl Journal Of Tuberculosis And Lung Disease. 2010, 14: 1193-1200.

Chan L.K., Patil N.G. and Ip M.S.M., The construction of a curriculum map for curriculum management, review, and reform. The sixth congress of the Asian Medical Education Association 2011, Kuala Lumpur, Malaysia, 23-26 March, The sixth congress of the Asian Medical Education Association 2011, Kuala Lumpur, Malaysia, 23-26 March.. 2011.

Han Q., Yeung S.C., Ip M.S.M. and Mak J.C.W., Intermittent hypoxia enhances inflammation and oxidative stress in Eahy926 endothelial cells via suppression of HO-1 expression, American Journal of Respiratory and Critical Care Medicine. 2011, 183: A2475.

Han Q., Yeung S.C., Ip M.S.M. and Mak J.C.W., Intermittent hypoxia enhances oxidative and inflammatory stresses in EAHY926 endothelial cells, Sixth International Symposium of Healthy Aging "A New Golden Age" 5-6 March 2011.

Han Q., Yeung S.C., Ip M.S.M. and Mak J.C.W., Role of HO-1 in intermittent hypoxia-induced inflammation in EAhy926 endothelial cell line, Journal of Pharmacological Sciences. 2011, 115: 158P.

Ip M.S.M., Are home sleep studies effective and cost-effective?, 15th Congress of the Asian Pacific Society of Respirology, Manila, Philippines. 2010.

Ip M.S.M., Associate Editor, Chest. 2010.

Ip M.S.M., Chairman, Scentific Meeting - "Recent discoveries in asthma pathogenesis - New therapeutic opportunities?", Hong Kong Sanatorium & Hospital and HKU Lecture, 2010. 2010.

Ip M.S.M., Chairman, Scientific Symposium on COPD, Hong Kong Thoracic Society/American College of Chest Physicians Scientific Meeting. 2010.

Ip M.S.M., Chairman, Symposium, Annual Scientific Meeting, Hong Kong Society of Sleep Medicine. 2010.

Ip M.S.M., Chairperson, Plenary Symposium, Hong Kong Allergy Convention. 2010.

Ip M.S.M., Diabetes mellitus and sleep apnoa (Plenary Lecture), ERS/ESRS Sleep & Breathing International Conference. 2011.

Ip M.S.M., Facilitator, Poster session on commorbidities in obstruction sleep apnea, ERS/ESRS Sleep & Breathing International Conference 2011, Prague, Czech Republic. 2011.

Ip M.S.M., Harasawa Award, Asian Pacific Society of Respirology. 2010.

Ip M.S.M., Honorary Advisor, The Hong Kong Asthma Society. 2011.

Ip M.S.M., Lung function testing in health and disease - Issues pertaining to Asia Pacific populations, Respirology. 2011, 16: 190-197.

Ip M.S.M., Member of Editorial Board, Sleep Medicine. 2011.

Ip M.S.M., Member, Steering Committee of European Respiratory Society Global Lung Taskforce. 2011.

Ip M.S.M., OSA and metabolic syndrome, The Second International Congress on Respiratory Disease, Guangzhou, China. 2011.

Ip M.S.M., Obstructive sleep apnea - an evolving minefield, 15th Congress of the Asian Pacific Society of Respiratory, Manila, Philippines. 2010.

Ip M.S.M., President, Asian Pacific Society of Respirology. 2010.

Ip M.S.M., Sleep breathing disorders and metabolism syndrome, 2011 Ruijin International Forum of Respiratory Medicine, Shanghai, China. 2011.

Ko F.W.S., Ip M.S.M., Chu C.M., So L.K.Y., Lam C.L.D. and Hui D.S.C., Prevalence of allergic rhinitis and its associated morbidity in adults with asthma: a multicentre study. , Hong Kong Medical Journal. 2010, 16(5): 354 - 361.

Lam B., Wong M.K.Y., Lu K.H., Au W.Y., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Liang R.H.S., Lam W.K., Ip M.S.M. and Lie A.K.W., Effects of Azithromycin in bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation – a randomized double-blinded placebo-controlled study, Bone Marrow Transplantation. 2011, Epub ahead of print.

Lam B., Sam K., Lam C.M., Lai A.Y.K., Lam C.L.D. and Ip M.S.M., The efficacy of oral appliances in the treatment of severe obstructive sleep apnea, Sleep and Breathing. 2011, 15(2): 195-201.

Lam C.L.D., Lam B., Wong M.K.Y., Lu K.H., Au W.Y., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Liang R.H.S., Lam W.K., Ip M.S.M. and Lie A.K.W., Effects of Azithromycin in bronchiolitis obliterans syndrome after hematopoietic SCT-a randomized double-blinded placebo-controlled study, Bone marrow transplantation. 2011, Epub ahead of print.

Lam C.L.D., Fu K.H., Lui M.M.S., Yung P.M., Cheung A.H.K., Lam W.K., Wistuba I.I., Tsao G.S.W., Ip M.S.M. and Minna J.D., Expression of nicotinic acetylcholine receptor in human bronchial epithelium in relation to airflow obstruction, American Thoracic Society Annual Meeting 2011.

Lam C.L.D., Lui M.M.S., Lam C.M., Ong L.H.Y., Lam K.S.L. and Ip M.S.M., Prevalence and recognition of obstructive sleep apnea in Chinese patients with type 2 diabetes mellitus, Chest. 2010, 138(5): 1101-1107.

Lam C.M., Lui M.M. and Ip M.S.M., Diabetes and metabolic aspects of OSA, In: McNicholas WT & Bonsignore MR, European Respiratory Monograph - Clinical Handbooks for the Respiratory Professional . European Respiratory Soceity, 2010, Chap 12, No. 50: pp. 189-215.

Lau K.W., Chan K.H., Yeung S.C., Ip M.S.M. and Mak J.C.W., Effects of cigarette smoke exposure on serum 5-HT levels in rats, American Journal of Respiratory and Critical Care Medicine. 2011, 183: A2454.

Leung G.K.K., Patil N.G. and Ip M.S.M., Introducing patient safety to undergraduate medical students - a pilot program by health care administrators , Medical Teacher. 2010, 32: e547-557.

Lo A.I.L., Huang Y., Lam S.Y., Cheung A.H.K., Au R., Leung C.C., Lam W.K., Ip M.S.M., Chan M.M.W. and Lam B., Early detection of central airway lung cancer in smokers with silicosis, International Journal of Tuberculosis and Lung Disease. 2011, 15(4): 523-527.

Lui M.M. and Ip M.S.M., Obstructive sleep apnea, In: Jindal SK, Textbook of Pulmonary & Critical Care Medicine. Jaypee Brothers Medical Publishers (P) Ltd, 2011, pp. 1593-1608.

Quanjer P.H., Stanojevic S., Stocks J., Hall G.L., Prasad K.V., Cole T.J., Rosenthal M., Perez-Padilla R., Hankinson J.L., Falaschetti E., Golshan M., Brunejreef B., Al-Rawas O., Kuhr J., Trabelsi Y. and Ip M.S.M., Changes in the FEV1/FVC ratio during childhood and adolescence: An intercontinental study, European Respiratory Journal. 2010, 36: 1391-1399.

Tang S.C.W., Lam B., Lam J.C., Yap D.Y., Ip M.S.M. and Lai K.N., Impact of nephrotic leg edema on OSA: gathering a unifying concept for the pathogenetic role of nocturnal rostral fluid shift, J Am Soc Nephrol. 2010, 21: 417A.

Researcher : Jim MH

List of Research Outputs

Yue W., Chong B.H., Zhang X., Liao S., Jim M.H., Kung A.W.C., Tse H.F. and Siu D.C.W., Hyperthyroidism-induced left ventricular diastolic dysfunction: implication in hyperthyroidism-related heart failure, Clin Endocrinol (Oxf). 2011, 74(5): 636-43.

Researcher : Jin O

List of Research Outputs

Jin O., Kavikondala S., Sun L.Y., Gu J.R., Fu R., Mok T.M.Y., Chan W.K., Yeung J.S.L., Nie Y. and Lau W.C.S., Abnormalities in circulating plasmacytoid dendritic cells in patients with systemic lupus erythematosus., Arthritis Research & Therapy. 2010, 12(4): R137.

Researcher : Jin Y

Project Title:	Cytogenetic and molecular genetic characterization of esophageal carcinomas
Investigator(s):	Jin Y, Kwong YL, Tsao GSW
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	10/2002

Researcher : Jong I

List of Research Outputs

Cheung P.P.Y., Chin W.Y. and Jong I., Home Blood Pressure Monitoring in the Management of Hypertensive Patients , Hong Kong Practitioner. 2010.

Researcher : Kavikondala S

List of Research Outputs

Jin O., Kavikondala S., Sun L.Y., Gu J.R., Fu R., Mok T.M.Y., Chan W.K., Yeung J.S.L., Nie Y. and Lau W.C.S., Abnormalities in circulating plasmacytoid dendritic cells in patients with systemic lupus erythematosus., Arthritis Research & Therapy. 2010, 12(4): R137.

Researcher : Kong MCW

Project Title:	Proliferation of stem cell-derived cardiomyocyte (CM)
Investigator(s):	Kong MCW, Tse HF
Department:	Medical Faculty
Source(s) of Funding:	Small Project Funding
Start Date:	08/2009
Completion Date:	01/2011

List of Research Outputs

Li R.A., Kong M.C.W. and Poon N.Y.E., Human pluripotent stem cells in cardiovascular research and regenerative medicine., Embryonic Stem Cells Book 2, 2011.

Li R.A., Kong M.C.W. and Poon N.Y.E., Pluripotent Stem Cell-Based Approaches for Myocardial Repair., Mol Pharm. In press., 2011.

Wang X., Chena S., Kong M.C.W., Wang Z., Costa K.D., Li R.A. and Sun D., Enhanced cell sorting and manipulation with combined optical tweezer and microfluidic chip technologies., Lab on a Chip. In press. . 2011.

Researcher : Kumana CR

List of Research Outputs

Kumana C.R. and Cheung B.M.Y., Thrombolytic therapy for acute ischaemic stroke: is the hype justified?, Hong Kong Med J. 2011, 17(1): 82-83.

Researcher : Kung AWC

Project Title:	Gene Identification for Osteoporosis using a Two Stage Genome-wide Association Strategy in the Chinese Population
Investigator(s):	Kung AWC, Huang Q, Sham PC
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2008
Completion Date:	11/2010

Project Title:	Cost-effective osteoporosis intervention thresholds for Hong Kong Southern Chinese postmenopausal women
Investigator(s):	Kung AWC, McGhee S
Department:	Medicine
Source(s) of Funding:	Health and Health Services Research Fund - Full Grants
Start Date:	10/2009

List of Research Outputs

Bow C.H.Y., Leung E., Cheung C.L., Xiao S., Loong C., Soong S.S., Tan K.C.B., Luckey M.M., Cauley J.A., Fujiwara S. and Kung A.W.C., Ethnic Difference of Clinical Vertebral Fracture Risk, 12th Regional Osteoporosis Conference, Hong Kong. 2011.

Bow C.H.Y., Cheung E., Cheung C.L., Xiao S., Loong C., Soong S.S., Tan K.C.B., Luckey M.M., Cauley J.A., Fujiwara S. and Kung A.W.C., Ethnic difference of clinical vertebral fracture risk, Osteoporosis International. 2011.

CHN L.O.O.N.G., Bow C.H.Y., Yeung S.C., Tan K.C.B. and Kung A.W.C., Bone Mineral Density in Patients with Spine Fracture Treated with Alendronate Sodium and Strontium Ranelate, 12th Regional Osteoporosis Conference, Hong Kong. 2011.

Cheung A., Leung F.K.L., Lau T.W. and Kung A.W.C., A Secondary Fracture Prevention Programme to Reduce Fractures, Hospital Admissions, and Mortality Rates at One and Five Years , 30th Annual Congress, Hong Kong Orthopaedic Association, Hong Kong, 27-28 Nov, 2010 . 2010.

Cheung C.L., Xiao S. and Kung A.W.C., Genetic epidemiology of age-related osteoporosis and its clinical application, Nature Reviews Rheumatology. 2010, 6(9): 507-517.

Cheung E.L.A.I.N.E., Tsang S.H.I.R.L.E.Y., Bow C.O.R.A., Soong C.I.S.S.Y., Yeung S.H.I.R.L.E.Y., Loong C.O.N.N.I.E., Cheung C.H.I.N.G.-.L.U.N.G., Lo S.U.E., Tam S.I.D.N.E.Y., Tang G.W.K. and Kung A.W.C., Bone loss during menopausal transition among southern Chinese women, Maturitas. elsevier, 2011, 69: 50-56.

Dai Z., Chung S.K., Miao D., Lau K.S., Chan A.W.H. and Kung A.W.C., Sodium/myo-inositol cotransporter 1 and myo-inositol are essential for osteogenesis and bone formation, Journal of Bone and Mineral Research. 2011, 26(3): 582-590.

Kwan S.H., Kung A.W.C. and Sham P.C., A Simple Bias Correction In Linear Regression For Quantitative Trait Association Under Two-tail Extreme Selection, Behavior Genetics . 2011.

Lai B.M.H., Lam C.L.K. and Kung A.W.C., Validation of the quality of life questionnaire of the European foundation for osteoporosis (QUALEFFO-31) in Chinese, Clinical Rheumatology. 2010, 29(9): 965-72.

Lam J.K., Lam C.W., Kung A.W.C., Tan K.C.B., Lau K.S. and Lam K.S.L., A man with hypophosphataemia, BMJ. 2011, 342:d773.

Lam J.K.Y., Lam K.S.L., Kung A.W.C., Tan K.C.B., Chow W.S. and Tso A.W.K., A woman with raised alkaline phosphatase and forearm deformity, BMJ. 2011, 342: d3435.

Leung F.K.L., Lau T.W., Kwan K., Chow S.P. and Kung A.W.C., Does timing of surgery matter in fragility hip fractures? Osteoporos Int. 2010 Dec;21(Suppl 4):S529-34. Epub 2010 Nov 6., 2010.

Li H.Y., Cheung C.L., Xiao S., Lau K.S., Gao Y., Bow C.H.Y., Huang Q.Y., Sham P.C. and Kung A.W.C., Identification Of Qtl Genes For Bmd Variation Using Both Linkage And Gene-based Association Approaches., Human Genetics. 2011.

Loong C.H.N., ELY L.E.U.N.G., Tan K.C.B. and Kung A.W.C., A Nurse-Led Clinic Reduced Osteoporosis Clinic Default Rate and Improved Drug-adherence Rate, 12th Regional Osteoporosis Conference, Hong Kong. 2011.

Styrkarsdottir U., Halldorsson B.V., Gudbjartsson D.F., Tang N., Koh J.M., Xiao S., Kwok T., Kim G.S., Chan J., Cherny S., Lee S.H., Kwok A., Ho S.C., Gretarsdottir S., Kostic J., Palsson S., Sigurdsson G., Sham P.C., Kim B., Kung A.W.C., Kim S., Woo J., Leung P.C., Kong A., Thorsteinsdottir U., Stefansson K. and Genetic Factors for Osteoporosis (GEFOS) Consortium , European Bone Mineral Density Loci are also associated with BMD in East-Asian Populations, PLoS ONE. 2010, 5(10): e13217.

Xiao S., Cherny S.S., Li H.Y., Gao Y., Tso H.W., Lau K.S., Luk K.D.K., Sham P.C. and Kung A.W.C., Association Of Jag1 Gene And Its Variant Sequence With Bone Mineral Density And Osteoporotic Fractures: A Genome-wide Association Study And Follow-up Replication Studies, The HKSEMR Annual Scientific Meeting and Annual General Meeting, 21 November, Hong Kong. 2010.

Xiao S., Gao Y., Cheung C.L., Bow C.H.Y., Lau K.S., Sham P.C., Tan K.C.B. and Kung A.W.C., Association of Cdx1 Binding Site of Periostin Gene with Bone Mineral Density and Vertebral Fracture Risk, The 3rd Joint Meeting of the European Calcified Tissue Society and the International Bone and Mineral Society, 7-11 MAY, Athens, Greece. Athens, Greece, 2011, 7-11 MAY.

Xiao S. and Kung A.W.C., Osteoporosis: Advances of Gene Mapping, The 6th International Huaxia Congress of Endocrinology, 10-12 December, Shanghai, China. Shanghai, China, 2010, 10-12 December.

Yue W., Chong B.H., Zhang X., Liao S., Jim M.H., Kung A.W.C., Tse H.F. and Siu D.C.W., Hyperthyroidism-induced left ventricular diastolic dysfunction: implication in hyperthyroidism-related heart failure, Clin Endocrinol (Oxf). 2011, 74(5): 636-43.

Researcher : Kung MHW

List of Research Outputs

Chan K.H., Kwan S.C., Ho W.L., Ho S.L., Chui W.H., Chu A.C.Y., Ho W.M., Zhang W.Y. and Kung M.H.W., Aquaporin-4 water channel expression by thymoma of patients with and without myasthenia gravis, Journal of Neuroimmunology. 2010, 227: 178-184.

Ho W.M., Ho W.L., Zhang W., Liu H., Kwok H.H., Yiu C.W., Chan K.H., Kung M.H.W., Ramsden D.B. and Ho S.L., Activation of c-Rel mediates neuroprotection via mitochondrial uncoupling protein-4 under NF-kB pathways, EMBO Meeting 2010, Barcelona, Spain (4-7 Sept, 2010). 2010.

Pang S.Y.Y., Lee C.N., Tsoi T.H., Yip K.K., Chan K.H., Kung M.H.W. and Ho S.L., Transient axonal glycoprotein-1 (TAG-1) polymorphism and its correlation with clinical features and prognosis in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), 63rd American Academy of Neurology Annual Meeting 2011, Honlolulu,Hawaii; Neurology. 2011, 76 (Suppl 4): A570.

Researcher : Kwan SC

List of Research Outputs

Chan K.H., Kwan S.C., Ho W.L., Ho W.M. and Ramsden D.B., Aquaporin-4 autoantibodies in neuromyelitis optica spectrum disorders: comparison between tissue-based and cell-based indirect immunofluorescence assays, 15th Research Postgraduate Symposium, LKS Faculty of Medicine, the University of Hong Kong. 2010.

Chan K.H., Kwan S.C., Ho W.L., Ho W.M., Chu A.C.Y. and Ramsden D.B., Aquaporin-4 autoantibodies in neuromyelitis optica spectrum disorders: comparison between tissue-based and cell-based indirect immunofluorescence assays, Journal of Neuroinflammation. 2010, 7(1): 50.

Chan K.H., Kwan S.C., Ho W.L., Ho S.L., Chui W.H., Chu A.C.Y., Ho W.M., Zhang W.Y. and Kung M.H.W., Aquaporin-4 water channel expression by thymoma of patients with and without myasthenia gravis, Journal of Neuroimmunology. 2010, 227: 178-184.

Chan K.H., Tse C. .T., Chung C.P., Lee R., Kwan S.C., Ho W.L. and Ho W.M., Brain Involvement In Neuromyelitis Optica Spectrum Disorders, Archives of Neurology. 2011, 68(11): 1432-1439.

Chan K.H., Kwan S.C., Zhang R., Ho W.L. and Ho W.M., Passive transfer of IgG from aquaporin-4 autoantibodies seropositive neuromyelitis optica patients to mice cause spinal cord aquaporin-4 loss without myelitis, 63rd American Academy of Neurology Annual Meeting, Neurology. 2011, 76 (Supplement 4): A537-538.

Tse C.T., Chung C.P., Tse M.M.Y., Ho S.L., Cheung K.S., Kwan S.C., Ho W.L., Ho W.M. and Chan K.H., Cerebral involvement in neuromyelitis optica spectrum disorders among Hong Kong Chinese, 16th Medical Research Conference, Department of Medicine, The University of Hong Kong, 2011. Hong Kong Medical Journal. 2011, 17 (Supplement 1): 55.

Tse C.T., Lee R., Kwan S.C., Ho W.L., Ho W.M. and Chan K.H., Cerebral involvement in neuromyelitis optica spectrum disorders with aquaporin-4 autoimmunity, Sixth International Symposium On Healthy Aging. 2011.

Zhou L., Chu L.W., Kwan S.C., Lam K.S.L., Ho W.L., Ho W.M. and Chan K.H., Plasma amyloid beta peptides and oligomers antibodies in Alzheimer's disease, 16th Medical Research Conference, Department of Medicine, The University of Hong Kong, 2011. Hong Kong Medical Journal . 2011, 17 (Supplement 1): 69.

Zhou L., Chu L.W., Kwan S.C., Lam K.S.L., Ho W.L., Ho W.M. and Chan K.H., Plasma amyloid beta peptides and oligomers levels in Alzheimer's disease, 16th Medical Research Conference, Department of Medicine, The University of Hong Kong, 2011. Hong Kong Medical Journal. 2011, 17 (Supplement 1): 69.

Zhou L., Chu L.W., Kwan S.C., Lam K.S.L., Ho W.L., Ho W.M. and Chan K.H., Plasma beta-amyloid peptides and serum associated beta-amyloid autoantibodies in patients with Alzheimer's disease, Alzheimer's Disease Conference 2011: From Public Health, Basci And Clinical Sciences To Therapeutic Insights. 2011.

Zhou L., Chu L.W., Kwan S.C., Lam K.S.L., Ho W.L., Ho W.M. and Chan K.H., Plasma b-amyloid Peptides And Serum Associated b-amyloid Autoantibodies In Alzheimer's Disease, Sixth International Symposium On Healthy Aging. 2011.

Researcher : Kwan SM

List of Research Outputs

Chu L.W., Luk J.K.H., Hui E., Chiu P.K.C., Chan S.Y., Kwan S.M., Kwok T., Lee D. and Woo J., Advance directive and end-of-life care preferences among Chinese nursing home residents in Hong Kong, J Am Med Dir Assoc. . 2011, 12(2): 143-52.

Researcher : Kwok HH

List of Research Outputs

Ho W.M., Ho W.L., Zhang W., Liu H., Kwok H.H., Yiu C.W., Chan K.H., Kung M.H.W., Ramsden D.B. and Ho S.L., Activation of c-Rel mediates neuroprotection via mitochondrial uncoupling protein-4 under NF-kB pathways, EMBO Meeting 2010, Barcelona, Spain (4-7 Sept, 2010). 2010.

Researcher : Kwok TK

List of Research Outputs

Tse M.Y.M., Li L.S.W., Cheung R.T.F. and Kwok T.K., Impact of stroke on autonomic nervous system, Sixteenth Medical Research Conference. 2011, 17 (Suppl 1): 56.

Researcher : Kwong YL

Project Title:	Provision of purine analogues for the treatment of patients with chronic lymphoid malignancies
Investigator(s):	Kwong YL, Liang RHS
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	07/1997

Project Title:	Molecular mechanisms and consequences of downregulation of p73 in natural killer cell lymphoma
Investigator(s):	Kwong YL
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Project Title:	Molecular basis of arsenic resistance in tumours
Investigator(s):	Kwong YL, Tse EWC
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	Provision of free cytogenetic and molecular testing for monitoring of disease relapse after bone marrow transplantation
Investigator(s):	Kwong YL, Liang RHS, Lie AKW, Au WY
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	11/2004

Project Title:	Provision of ibritumomab for the treatment of lymphoma
Investigator(s):	Kwong YL, Liu KY
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2008

Project Title:	The role of Pin1 in tumour invasion and metastasis in hepatocellular carcinoma
Investigator(s):	Kwong YL, Tse EWC
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2008
Completion Date:	12/2010

Project Title:	Provision of oral arsenic trioxide free to patients with cancers
Investigator(s):	Kwong YL, Au WY, Chim JCS
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2008

Project Title:	Provision of ibritumomab for the treatment of Iymphoma
Investigator(s):	Kwong YL, Liu KY
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	05/2010

Project Title:	Provision of clofarabine for the treatment of relapsed or refractory acute leukaemia
Investigator(s):	Kwong YL, Leung AYH, Tse EWC
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	08/2010

List of Research Outputs

Chan K.S., Au W.Y., Wong C.Y., Liang R.H.S., Leung A.Y.H., Kwong Y.L. and Khong P.L., Metabolic activity measured by F-18 FDG PET in NK-cell lymphoma compared to aggressive B- and T-cell lymphomas, Clinical Nuclear Medicine . 2010, 35: 571-575.

Chan T.S., Au W.Y., Lam K., Lam Y.F., So J.C.C., Leung A.Y.H., Tse E.W.C., Lie A.K.W. and Kwong Y.L., Donor cell leukaemia after allogeneic haematopoietic SCT followed by prolonged thalidomide maintenance for multiple myeloma, Bone Marrow Transplant. 2011, [Epub ahead of print].

Chen S.P.L., Poon D.W.T., Mak C.M., Kwong Y.L., Chan A.Y.W. and Tam S., Application of pharmacogenetics: UGT1A1*28 and nilotinib-induced unconjugated hyperbilirubinaemia in a patient with chronic myeloid leukaemia, Pathology. 2011, 43(3): 273-4.

Chim J.C.S., Sim J.P., Chan C.C., Kho B.C., Chan J.C., Wong L.G., Law M., Liang R.H.S. and Kwong Y.L., Impact of JAK2V617F mutation on thrombosis and myeloid transformation in essential thrombocythemia: a multivariate analysis by Cox regression in 141 patients , Haematology. 2010, 15(4): 187-92.

Gill H., Chim J.C.S., Au W.Y., Loong F., Tse E.W.C., Leung A.Y.H. and Kwong Y.L., Non-gastric marginal zone B cell lymphoma: clinicopathologic features and treatment results, Ann Hematol. 2011, [Epub ahead of print].

Gill H., Choi W.L. and Kwong Y.L., Refractory anemia with ringed sideroblasts: more than meets the eye, Journal of Clinical Oncology. 2010, 28: e654-e655.

Gill H.S., Lau W.H., Chan A.C., Leung R.Y.Y., Khong P.L., Leung A.Y.H. and Kwong Y.L., CD20 expression in natural killer T cell lymphoma, Histopathology . 2010, 57: 157-159.

Gu J., Chan T., Zhang J., Leung A.Y.H., Kwong Y.L. and Khong P.L., Whole-body diffusion weighted imaging (DWI): the added value to whole-body MRI at initial diagnosis of lymphoma, American Journal of Roentgenology (in press). 2011.

He F., Kwong Y.L. and Ho J.C.M., In vitro growth inhibitory effects of arsenic trioxide in non-small cell lung cancer with different K-ras mutations. FEBS Meeting 2010, FEBS Journal. 2010, 277 (suppl 1): 136 (abstract: B2.61).

Ho S.L., Loong F., Lam C.C.K., Anthony M. and Kwong Y.L., F-18 Fluorodeoxyglucose non-avid hepatosplenic T cell lymphoma: a diagnostic pitfall., Ann Hematol.. 2011.

Kwong Y.L. and Khong P.L., Central palatal perforation in nasal natural killer cell lymphoma, British Journal of Haematology . 2011, 152(1): 2.

Lam B., Wong M.K.Y., Lu K.H., Au W.Y., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Liang R.H.S., Lam W.K., Ip M.S.M. and Lie A.K.W., Effects of Azithromycin in bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation – a randomized double-blinded placebo-controlled study, Bone Marrow Transplantation. 2011, Epub ahead of print.

Lam C.L.D., Lam B., Wong M.K.Y., Lu K.H., Au W.Y., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Liang R.H.S., Lam W.K., Ip M.S.M. and Lie A.K.W., Effects of Azithromycin in bronchiolitis obliterans syndrome after hematopoietic SCT-a randomized double-blinded placebo-controlled study, Bone marrow transplantation. 2011, Epub ahead of print.

Tse E.W.C., So J.C.C., Cheung W.W.W. and Kwong Y.L., T-cell prolymphocytic leukaemia: spontaneous immunophenotypical switch from CD4 to CD8 expression, Ann Hematol. 2010, 90(4): 479-81.

Wong M.K.Y., Loong F., Khong P.L., Kwong Y.L. and Leung A.Y.H., Mediastinal cryptococcosis masquerading as therapy-refractory lymphoma, Annals of Hematology. 2010, Epub.

Researcher : Lai AYK

List of Research Outputs

Lam B., Sam K., Lam C.M., Lai A.Y.K., Lam C.L.D. and Ip M.S.M., The efficacy of oral appliances in the treatment of severe obstructive sleep apnea, Sleep and Breathing. 2011, 15(2): 195-201.

Researcher : Lai CL

Project Title:	A preliminary assessment of safety and antiviral activity of open-label entecavir plus lamivudine therapy in subjects with chronic hepatitis B who have viremia on monotherapy in other entecavir trials
Investigator(s):	Lai CL, Yuen RMF
Department:	Medicine
Source(s) of Funding:	Bristol-Myers-Squibb (HK) - General Award
Start Date:	01/2003

Project Title:	Long-term assessment of treatment outcomes with entecavir and lamivudine for chronic hepatitis B infection in patients who have enrolled in phase iii entecavir trials
Investigator(s):	Lai CL, Yuen RMF
Department:	Medicine
Source(s) of Funding:	Bristol-Myers-Squibb (HK) - General Award
Start Date:	10/2003

Project Title:	A randomized, double-blind trial of Telbivudine (LdT) versus Lamivudine in adults with decompensated chronic hepatitis B and evidence of cirrhosis
Investigator(s):	Lai CL, Yuen RMF
Department:	Medicine
Source(s) of Funding:	Idenix Pharmaceuticals, Inc - General Award
Start Date:	01/2004

List of Research Outputs

But D.Y., Yuen R.M.F., Fung J.Y.Y. and Lai C.L., Safety evaluation of telbivudine., Expert Opin Drug Saf. 2010, 9(5): 821-9.

Chang T.T., Liaw Y.F., Wu S.S., Schiff E., Han K.H., Lai C.L., Safadi R., Lee S.S., Halota W., Goodman Z., Chi Y.C., Zhang H., Hindes R., Iloeje U., Beebe S. and Kreter B., Long-term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B., Hepatology. 2010, 52(3): 886-93.

Fung J.Y.Y., Lai C.L., Cheng C.T.K., Wu C.H., Wong D.K.H. and Yuen R.M.F., Mild-to-moderate elevation of alanine aminotransferase increases liver stiffness measurement by transient elastography in patients with chronic hepatitis B. [Epub 2010 Dec 14], Am J Gastroenterol . 2010, 106(3): 492-6.

Fung J.Y.Y., Seto W.K., Lai C.L., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Profiles of HBV DNA in a large population of Chinese patients with chronic hepatitis B: implications for antiviral therapy., Journal of hepatology : the journal of the European Association for the Study of the Liver. 2011, 54: 195-200.

Fung J.Y.Y., Lai C.L., Seto W.K., Wong D.K.H. and Yuen R.M.F., Prognostic significance of liver stiffness for hepatocellular carcinoma and mortality in HBeAg-negative chronic hepatitis B., Journal of Viral Hepatitis. 2010, [Epub ahead of print].

Fung J.Y.Y., Lai C.L., Yuen J.C.H., Cheng C.T.K., Wu C.H., Wong D.K.H., Seto W.K., Hung I.F.N. and Yuen R.M.F., Randomized trial of lamivudine versus entecavir in entecavir-treated patients with undetectable hepatitis B virus DNA: Outcome at 2 years., Hepatology. 2011, 53(4): 1148-53.

Fung J.Y.Y., Lai C.L., But D.Y.K., Hsu A.S.J., Seto W.K., Cheng C.T.K., Wong D.K.H. and Yuen R.M.F., Reduction of liver stiffness following resolution of acute flares of chronic hepatitis B., Hepatol Int . 2010, 4(4): 716-22.

Fung J.Y.Y., Lai C.L., Wong D.K.H., Seto W.K. and Yuen R.M.F., Significant changes in liver stiffness measurement using transient elastography in hepatitis B patients – 3 year follow-up study. , Hepatology. 2010, 52(4 Suppl): 411A.

Fung J.Y.Y., Lai C.L., Wong D.K.H., Seto W.K., Hung I.F.N. and Yuen R.M.F., Significant changes in liver stiffness measurements in patients with chronic hepatitis B: 3 year follow-up study. [Epub 2011 Jan 7], J Viral Hepat . 2011, 18(7): e200-5.

Fung J.Y.Y., Lai C.L., Wong D.K.H., Seto W.K. and Yuen R.M.F., Switching to lamivudine in entecavir-treated patients with undetectable HBV DNA – final results at 96 weeks., Hepatology. 2010, 52(4 Suppl): 144A.

Fung J.Y.Y., Lai C.L., Seto W.K. and Yuen R.M.F., The use of transient elastography in the management of chronic hepatitis B. [Epub ahead of print], Hepatol Int . 2011.

Fung J.Y.Y., Lai C.L. and Yuen R.M.F., To stop or not to stop: The quest for long-term viral suppression., J Gastroenterol Hepatol . 2011, 26(3): 420-2.

Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Updates in the treatment of chronic hepatitis C., Medical Diary. 2010, 15(12): 12-15.

Hsu A.S.J., Lai C.L. and Yuen R.M.F., Update on risk of hepatocellular carcinoma in chronic hepatitis B virus infection. 2011;., Current Hepatitis Reports. 2011, 10(2): 106-111.

Lai C.L., A critical review of the treatment guidelines of chronic hepatitis B, 3^rd Kolkata Liver Meeting, Kolkata, India, December 3-5. 2010.

Lai C.L., Ahn S.H., Lee K.S., Um S.H., Cho M., Yoon S.K., Lee J.W., Park N.W., Kwon Y.O., Sohn J.H., Lee J.Y., Park H.E., Kim J.A., Han K.H. and Yuen R.M.F., A phase IIB study of the efficacy and safety of LB80380 vs entecavir in treatkent-naïve patients with chronic hepatitis B, 46^th Annual Meeting of the European Association for the Study of the Liver (EASL) - The International Liver Congress 2011 in Berlin, Germany between March 30 - April 3. 2011, Abstract No. 1353.

Lai C.L., An update of chronic hepatitis B treatment guidelines, Tenofovir Disoproxil Fumarate Launch Symposium "A New Era for the Treatment of Chronic Hepatitis B", Hong Kong, March 22. 2011.

Lai C.L., An update on hepatitis B and its current management, Seminar of Infection Control Association of Macao, Macau, October 15. Macau, 2010.

Lai C.L., Baraclude Asian cohort efficacy, resistance and histology data and Hong Kong 4 years real life data, BMS Symposium ‘Hepatitis B treatment: a closer look at Asian patients’, Seoul, Gwangju, Daejeon and Incheon, Korea, April 19-23. 2011.

Lai C.L., Chairman, Tenofovir Disoproxil Fumarate Launch Symposium "A New Era for the Treatment of Chronic Hepatitis B", Hong Kong, March 22. 2011.

Lai C.L. and Chongsrisawat V., Co-chairman of a concurrent symposium ‘Uncommon hepatitis C virus genotypes’, 21^st International Conference of the Asian Pacific Association for Studies of the Liver (APASL), Bangkok, Thailand, February 17-20. 2011.

Lai C.L., Drug-resistant mutants – the Achilles heel of therapy: management and newer anti-virals in pipeline, 3^rd Kolkata Liver Meeting, Kolkata, India, December 3-5. 2010.

Lai C.L., Durability of HBeAg Seroconversion, Gilead Medical Affairs Advisory Program entitled ‘When to Stop Therapy in Chronic Hepatitis B’, San Francisco, USA, June 16-17. 2011.

Lai C.L., Immunosuppression and Reactivation of Chronic Hepatitis B, 14^th Congress of Asia Pacific League of Associations for Rheumatology (APLAR 2010), Hong Kong, July 11-15, 2010. 2010.

Lai C.L., Management of Chronic Hepatitis B Infection, State-of-the-Art Lecture, Falk Symposium – Gut and Liver, Beijing, China, August 27-28, 2010. 2010.

Lai C.L. and Yuen R.M.F., Management of chronic hepatitis B., In: In Chen CW, Cheng J, Gines P, Quyang Q, Scholmerich J eds, Gut and Liver. Falk Symposium 174. Basel, Karger, 2011, 95-101.

Lai C.L., Moderator, 3^rd Kolkata Liver Meeting, Kolkata, India, December 3-5. Kolkata, India, 2010.

Lai C.L., Optimal management in 2011 and beyond, BMS Satellite Symposium "Future prospects in the progression of liver disease from viral hepatitis to hepatocellular carcinoma" at the 21^st International Conference of the Asian Pacific Association for Studies of the Liver (APASL), Bangkok, Thailand, Feb 17-20. 2011.

Lai C.L., Optimal treatment of chronic hepatitis B with long-term therapy, Post APASL/EASL Symposium, Kaohsiung, Taiwan, April 16. 2011.

Lai C.L., Optimal treatment of chronic hepatitis B with long-term therapy, Seminar on Viral Hepatitis for Nurses, Centre for Health Protection, Hong Kong Central Library, Hong Kong, May 19. 2011.

Lai C.L., Ahn S.H., Lee K.S., Um S.H., Cho M., Yoon S.K., Lee J.W., Park N.W., Kwon Y.O., Sohn J.H., Lee J.Y., Park H.E., Kim J.A., Han K.H. and Yuen R.M.F., Oral presentation "A phase IIb study of the efficacy and safety of LB80380 vs entecavir in treatment-naive patients with chronic hepatitis B", Journal of hepatology : the journal of the European Association for the Study of the Liver. 2011, 54 Suppl 1: S535.

Lai C.L., Speaker Consultant to give Baraclude slide presentations. , FACE B Speaker Programs in New York, Boston, San Francisco and Los Angeles, USA between October 25 to 28. 2010.

Lai C.L., State-of-the-Art Lecture entitled "Management of Chronic Hepatitis B Infection". , Falk Symposium – Gut and Liver, Beijing, China, August 27-28. 2010.

Lai C.L. and Yuen R.M.F., Systemic corticosteroid and reactivation of chronic hepatitis B., Respiratory . 2010, 15(7): 1017-8.

Lai C.L., The evolving future of hepatitis B treatment: latest thinking and emerging practice, Gilead Satellite Symposium 'Enlightening the Future' at the 21^st International Conference of the Asian Pacific Association for Studies of the Liver (APASL), Bangkok, Thailand, Feb 17-20. 2011.

Lai C.L., The evolving strategies in drug resistance management, GSK CHB evening symposium, Hong Kong, April 28. 2011.

Lai C.L., The third first line agent, International Symposium on Hepatology 2010, The Hong Kong Association for the Study of Liver Diseases, Hong Kong, November 21. 2010.

Lam C.L.K., Lam T.P., Lai C.L., Yuen R.M.F., Fong D.Y.T., McGhee S. and Leung G.M., Health-related Quality of Life and Health Preference of Patients with Chronic Hepatitis B Infections, Poster presented at the Health Research Symposium 2010 in Hong Kong on Sept 11, 2010. Hong Kong.

Lo C.L.R., Tung K.K., Mak K.M., Fatima S., Zhou H., Poon R.T.P., Yuen R.M.F., Lai C.L., Li J., Luk J.M.C. and Ng I.O.L., Both tissue and serum dickkopf-1 (DKK-1) levels have clincopathologic and prognostic significance in hepatocellular carcinoma., Hepatology . 2010, 52(4 Suppl): 282A.

Lok A., Keefe E.B., Lai C.L., Lampertico P., Chotiyaputta W., Thong-Uthaisri P., Lai W. and Poordad F., Co-panelist at the Case Discussion Session “Discussion: Challenging cases of CHB and CHC", 21^st International Conference of the Asian Pacific Association for Studies of the Liver (APASL), Bangkok, Thailand, February 17-20. 2011.

Pan C., Tong M.J., Kowdley K.V., Hu K.Q., Chang T.T., Lai C.L., Yoon S.K., Lee S.S., Cohen D.S., Tang H. and Tsai N.C.S.C., Long-term entecavir treatment for up to 5 years in Asians with HBeAg-positive nucleos(t)ide naïve chronic hepatitis B: results from ETV-022 and -901., Hepatology. 2010, 52(4) Suppl: 145A.

Seto W.K., Lai C.L., Fung J.Y.Y., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Elevation of ALT fails to predict significant histologic abnormalities in chronic hepatitis B patients. , Hepatol Int . 2011, 5: 164.

Seto W.K., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Hung I.F.N. and Yuen R.M.F., HBV DNA levels after 12 weeks of telbivudine treatment in chronic hepatitis B predicts long-term outcome., Hepatology . 2010, 52(4 Suppl): 143A.

Seto W.K., Ng M.M.T., Chan P., Ng I.O.L., Cheung S.C.W., Hung I.F.N., Yuen R.M.F. and Lai C.L., Ketamine-induced cholangiopathy: a case report., Am J Gastroenterol. 2011, 106(5): 1004-5.

Seto W.K., Lai C.L., Fung J.Y.Y. and Yuen R.M.F., Lamivudine therapy for chronic hepatitis B., Ann Gastroenterol Hepatol. 2010, 1(1): 63-70.

Seto W.K., Lai C.L., Fung J.Y.Y., Hung I.F.N., Yuen J.C.H., Young J.L.P., Wong D.K.H. and Yuen R.M.F., Natural history of chronic hepatitis C: Genotype 1 versus genotype 6, 2010, 53: 444-8.

Seto W.K., Lai C.L., Fung J.Y.Y., Hung I.F.N., Yuen J.C.H., Young J.L.P., Wong D.K.H. and Yuen R.M.F., Natural history of chronic hepatitis C: genotype 1 versus genotype 6., Journal of hepatology : the journal of the European Association for the Study of the Liver. 2010, 53(3): 444-8.

Seto W.K., Lai C.L., Fung J.Y.Y., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Outcome of 4-year tratemnt of entecavir for treatment-naïve chronic hepatitis B - Poster presentation, 46 ^th Annual Meeting of the European Association for the Study of the Liver - The International Liver Congress™ 2011 in Berlin, Germany between March 30 - April 3. 2011, Abstract No. 748.

Seto W.K., Lai C.L., Fung J.Y.Y., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Outcome of 4-year treatment of entecavir for treatment-naive chronic hepatitis B., J Hepatol . 2011, 54: S301.

Seto W.K., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Hung I.F.N. and Yuen R.M.F., Significance of HBV DNA levels at 12 weeks of telbivudine treatment and the 3 years treatment outcome. {Epub ahead of print], J Hepatol. 2010, 55(3): 522-8.

Seto W.K., Yuen R.M.F., Fung J.Y.Y. and Lai C.L., Tenofovir disoproxil fumarate in the treatment of chronic hepatitis B. [Epub ahead of print], Hepatol Int. 2011.

Seto W.K., Tanaka Y., Liu K., Lai C.L. and Yuen R.M.F., The effects of IL-28B and ITPA polymorphisms on treatment of hepatitis B virus genotype 6. , Am J Gastroenterol . 2011, 106(5): 1007-8.

Wong D.K.H., Lai C.L., Seto W.K., Fung J.Y.Y., Huang F.Y., Hung I.F.N. and Yuen R.M.F., Efficacies of one year nucleos(t)ide analogue therapy in intrahepatic HBV DNA and covalently closed circular DNA reduction. , J Hepatol (Poster presentation at the 46th Annual Meeting of EASL, Berlin, March 30 - April 3, 2011).. 2011, 54: S303.

Wong D.K.H., Huang F.Y., Poon R.T.P., Lai C.L., Fung J.Y.Y., Seto W.K., Hung I.F.N. and Yuen R.M.F., HBV replicative activity in patients with cryptogenic cause of hepatocellular carcinoma, Hepatology. 2010, 52: 247A.

Yeung P., Wong D.K.H., Lai C.L., Fung J.Y.Y., Seto W.K. and Yuen R.M.F., Association of Hepatitis B Virus Pre-S Deletions with the Development of Hepatocellular Carcinoma in Chronic Hepatitis B, Journal of Infectious Diseases. 2011, 203: 646-54.

Yeung P., Wong D.K.H., Lai C.L., Fung J.Y.Y., Seto W.K. and Yuen R.M.F., Association of hepatitis B virus pre-S deletions with the development of hepatocellular carcinoma in chronic hepatitis B. 2011;, J Infect Dis . 2011, 203(5): 646-54.

Yeung P., Wong D.K.H., Lai C.L., Fung J.Y.Y., Seto W.K. and Yuen R.M.F., Profile of pre-S deletions in the natural history of chronic hepatitis B infection, Journal of Medical Virology. 2010, 82: 1843-9.

Yeung P., Wong D.K.H., Lai C.L., Fung J.Y.Y., Seto W.K. and Yuen R.M.F., Profile of pre-S deletions in the natural history of chronic hepatitis B. 2010;, J Med Virol . 2010, 82(11): 1843-9.

Yuen R.M.F., Lee C.K., Wong D.K.H., Fung J.Y.Y., Hung I.F.N., Hsu A., But D.Y.K., Cheung T.K., Chan P., Yuen J.C.H., Fung F.K.C., Seto W.K., Lin C.K. and Lai C.L., Prevalence of occult hepatitis B infection in a highly endemicea for chronic hepatitis B: A study of large blood-donor population, GUT. 2010, 59(10): 1389-93.

Yuen R.M.F., Seto W.K., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H. and Lai C.L., Three years of continuous entecavir therapy in treatment-naïve chronic hepatitis B patients: viral suppression, viral resistance and clinical safety. [Epub 2011 Mar 1], Am J Gastroenterol . 2011, 106(7): 1264-71.

Yuen R.M.F., Wong D.K.H., Lee C.K., Tanaka Y., Allain J.P., Fung J.Y.Y., Leung J., Lin C.K., Sugiyama M., Sugauchi F., Mizokami M. and Lai C.L., Transmissibility of hepatitis B virus (HBV) infection through blood transfusion from blood donors with occult hepatitis B virus infection. [Epub 2011 Jan 18], Clin Infect Dis. 2011, 52(5): 624-32.

Yuen R.M.F. and Lai C.L., Treatment of chronic hepatitis B: Evolution over two decades., Journal of Gastroenterology and Hepatology. 2011, 26 Suppl 1: 138-43.

Yuen R.M.F. and Lai C.L., Treatment of chronic hepatitis B: evolution over two decades. , J Gastroenterol Hepatol . 2011, 26 (Suppl 1): 138-43.

Researcher : Lai KN

Project Title:	The role of the renin-angiotensin system in the tubulointerstitial injury of IgA nephropathy (IgAN)
Investigator(s):	Lai KN, Leung JCK
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004

Project Title:	Podocyte injury in IgA nephropathy
Investigator(s):	Lai KN, Leung JCK
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2008
Completion Date:	06/2011

List of Research Outputs

Au W.S., Chan G., Leung J.C.K., Chan L.Y., Lan H.Y., Lai K.N. and Tang S.C.W., Ac-SDKP reduces proinflammatory response in PTEC during pathogenic albumin load, J Am Soc Nephrol. 2010, 21: 279A.

Cheung C.Y., Lam M.F., Lee K.C., Chan G.S.W., Chan K.W., Chau K.F., Li C.S., Chan D.T.M. and Lai K.N., Renal cell carcinoma of native kidney in Chinese renal transplant recipients: a report of 12 cases and a review of the literature, International Urology and Nephrology. 2011, 43(3): 675-80.

Huang W., Gu H., Li R., Lou T., Zhang J., Shi W., Ye Z., Zhou Y., Li C., Xiong S., Li L., Wu C., Leung J.C.K., Lam M.F., Lai K.N. and Wang A.Y.M., Association of -27T>C and its haplotype at the putative promoter for IgA-specific receptor gene with IgA nephropathy among the Chinese Han population, Nephrology Dialysis Transplantation. 2011, 26(8): 2537-44.

Lai K.N., Chan L.Y., Guo H., Tang S.C.W. and Leung J.C.K., Additive effect of PPAR-γ agonist and ARB in treatment of experimental IgA nephropathy, Pediatric Nephrology. 2011, 26(2): 257-266.

Lai K.N., Lam M.F., Leung J.C.K., Chan L.Y. and Tang S.C.W., Clinical and biochemical profile of a low-glucose degradation product peritoneal dialysis fluid: a four-year study, J Am Soc Nephrol. 2010, 21: 307A.

Lai K.N. and Tang S.C.W., Diabetes and the Kidney, Edited by K.N. Lai and S.C.W. Tang, Publisher: S Karger AG, Basel, Switzerland. 2011.

Lai K.N., Leung J.C.K. and Tang S.C.W., The Renin-Angiotensin System, In: Diabetes and the Kidney, Edited by K.N. Lai and S.C. Tang, S Karger AG, Basel, Switzerland. 2011, 135-144.

Lai K.N., Leung J.C.K. and Tang S.C.W., The renin-angiotensin system, Contributions to Nephrology. 2011, 170: 135-44.

Leung J.C.K., Chan L.Y., Tang S.C.W. and Lai K.N., Glomerulotubular interaction in IgA nephropathy induces oxidative damages in tubular epithelial cells: role of crosstalk between angiotensin II and aldosterone. Proceedings of the World Congress of Nephrology April 2011, J Am Soc Nephrol. 2010.

Tang S.C.W., Chan Y.Y., Leung J.C.K., Cheng A.S., Lan H.Y. and Lai K.N., Additive Renoprotective Effects Of B2-kinin Receptor Blocker And PPAR-y Agonist In Uninephrectomized Db/db Mice [journal Impact Factor 4.602] (in Press), Lab Invest . 2011, 91(9): 1351-62.

Tang S.C.W., Chan L.Y., Leung J.C.K., Lan H.Y. and Lai K.N., Additive renoprotective effects of B2-kinin receptor blocker and PPAR-γ agonist in uninephrectomized db/db mice, J Am Soc Nephrol. 2010, 21: 692A.

Tang S.C.W., Lin M., Tam S., Au W.S., Ma K.M., Yap D.Y., Ho Y.W. and Lai K.N., Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-labeled pilot study. Proceedings of the World Congress of Nephrology April 2011, J Am Soc Nephrolol. 2010.

Tang S.C.W., Lin M., Tam S., Au W.S., Ma M.K., Yap D.Y., Ho Y.W. and Lai K.N., Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-labeled pilot study, Nephrology Dialysis Transplantation. 2011.

Tang S.C.W., Leung J.C.K. and Lai K.N., Diabetic Tubulopathy: an Emerging Entity, In: Diabetes and the Kidney, Edited by K.N. Lai and S.C. Tang, S Karger AG, Basel, Switzerland. 2011, 124-134.

Tang S.C.W., Leung J.C.K. and Lai K.N., Diabetic tubulopathy: an emerging entity, Contributions to Nephrolology. 2011, 170: 124-134.

Tang S.C.W., Chan Y.Y., Leung J.C.K., Cheng A.S., Lin M., Lan H.Y. and Lai K.N., Differential effects of advanced glycation end-products on renal tubular cell inflammation, Nephrology (Carlton, Vic). 2011, 16(4): 417-25.

Tang S.C.W., Lam B., Lam J.C., Yap D.Y., Ip M.S.M. and Lai K.N., Impact of nephrotic leg edema on OSA: gathering a unifying concept for the pathogenetic role of nocturnal rostral fluid shift, J Am Soc Nephrol. 2010, 21: 417A.

Tang S.C.W., Leung J.C.K., Chan L.Y., Lan H.Y. and Lai K.N., Renoprotection by rosiglitazone in accelerated type 2 diabetic nephropathy: role of STAT1 inhibition and nephrin restoration, American Journal of Nephrology. 2010, 32: 145-155.

Tang S.C.W., Leung J.C.K. and Lai K.N., The Kallikrein-Kinin System, In: Diabetes and the Kidney, Edited by K.N. Lai and S.C. Tang, S Karger AG, Basel, Switzerland. 2011, 145-155.

Tang S.C.W., Leung V.T.M., Chan Y.Y., Wong S.S., Chu D.W., Leung J.C.K., Ho Y.W., Lai K.N., Ma L., Elbein S.C., Bowden D.W., Hicks P.J., Comeau M.E., Langefeld C.D. and Freedman B.I., The acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with nephropathy in Chinese patients with type 2 diabetes, Nephrology Dialysis Transplantation. 2010, 25(12): 3931-4.

Tang S.C.W., Leung J.C.K. and Lai K.N., The kallikrein-kinin system, Contributions to Nephrology. 2011, 170: 145-155.

Yang F., Huang X.R., Chung A.C., Hou C.C., Lai K.N. and Lan H.Y., Essential role for Smad3 in angiotensin II-induced tubular epithelial-mesenchymal transition, J Pathol. 2010, 221(4): 390-401.

Yap D.Y., Chu F.S.K., Chu S.S.M., Tam P.C., Tam S., Chan D.T.M., Lai K.N. and Tang S.C.W., CT angiography versus conventional digital angiography in preoperative assessment for Chinese living kidney donors, Journal of Nephrology. 2010, 23(6): 711-6.

Yap D.Y., Ma M.K., Lai A.S., Chan S.Y., Seto W.K., Lam M.F., Chan D.T.M. and Lai K.N., Superior mesenteric artery syndrome complicating dialysis patients with peritoneal failure-report of 3 cases, Clinical Nephrology. 2011, 75 Suppl 1: 37-41.

Yap D.Y., Tso W.K., Chu F.S., Chan D.T.M., Lai K.N. and Tang S.C.W., Transhepatic placement of hemodialysis catheter : a solution for vascular access exhaustion, Nephrology. 2010, 15(6): 661-2.

Yip T.P.S., Tse K.C., Ng F.S.K., Hung I.F.N., Lam M.F., Tang S.C.W., Lui S.L., Lai K.N., Chan D.T.M. and Lo W.K., Clinical course and outcomes of single-organism Enterococcus peritonitis in dialysis patients, Peritoneal Dialysis International. 2011, 31.

Researcher : Lai KWH

List of Research Outputs

Ho J.C.Y., Zhou T., Lai K.W.H., Huang Y., Chan Y.C., Li X., Wong L.Y. .N., Li Y., Au K.W., Guo D., Xu J., Siu D.C.W., Pei D., Tse H.F. and Esteban M.A., Generation of induced pluripotent stem cell lines from 3 distinct laminopathies bearing heterogeneous mutations in lamin A/C., Aging (Albany NY). 2011, 3(4): 380-90.

Lee Y.K., Ng K.M., Lai K.W.H., Chan Y.C., Lau Y.M., Lian Q., Tse H.F. and Siu D.C.W., Calcium Homeostasis in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes., Stem Cell Reviews and Reports. 2011.

Li M., Ho J.C.Y., Lai K.W.H., Au K.W., Xu A., Cheung B.M.Y., Lam K.S.L. and Tse H.F., Hypoadiponectinemia and its Impact on circulating endothelial progenitor cells in patients with type 2 diabetes - adiponectin and endothelial progenitor cells, Diabetes/Metab Res Rev. 2010, 27: 185-94.

Li M., Ho J.C.Y., Lai K.W.H., Au K.W., Xu A., Cheung B.M.Y., Lam K.S.L. and Tse H.F., The decrement in circulating endothelial progenitor cells (EPCs) in type 2 diabetes is independent of the severity of the hypoadiponectemia, Diabetes Metab Res Rev. 2011, 27(2): 185-194.

Liao S., Liu Y., Siu D.C.W., Zhang Y., Lai K.W.H., Au K.W., Lee Y.K., Li R.A. and Tse H.F., Proarrhythmic risk of embryonic stem cell-derived cardiomyocyte transplantation in infarcted myocardium, Heart Rhythm. 2010, 7(12): 1852-9.

Ng K.M., Lee Y.K., Lai K.W.H., Chan Y.C., Fung M.L., Tse H.F. and Siu D.C.W., Exogenous Expression of Human apoA-I Enhances Cardiac Differentiation of Pluripotent Stem Cells., PLoS One. 2011.

Researcher : Lai TST

List of Research Outputs

Chan J.F.W., To K.K.W., Tse H., Lau C.Y., Li W.S., Hung I.F.N., Chan K.H., Cheng V.C.C., Lai T.S.T., Woo P.C.Y., Chan E.Y.T. and Yuen K.Y., The lower serum immunoglobulin G2 level in severe cases than in mild cases of pandemic H1N1 2009 influenza is associated with cytokine dysregulation, Clinical and Vaccine Immunology. 2010, 18: 305-310.

Researcher : Lai WHK

List of Research Outputs

Mok T.M.Y., Yiu K.H., Wong C.Y., Qiuwaxi J., Lai W.H.K., Wong R.W.S., Tse H.F. and Lau W.C.S., Low circulating level of CD133+KDR+cells in patients with systemic sclerosis., Clinical and Experimental Rheumatology. 2010, 28(5 Suppl 62): S19-25.

Researcher : Lam B

List of Research Outputs

Lam B., Wong M.K.Y., Lu K.H., Au W.Y., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Liang R.H.S., Lam W.K., Ip M.S.M. and Lie A.K.W., Effects of Azithromycin in bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation – a randomized double-blinded placebo-controlled study, Bone Marrow Transplantation. 2011, Epub ahead of print.

Lam B., Sam K., Lam C.M., Lai A.Y.K., Lam C.L.D. and Ip M.S.M., The efficacy of oral appliances in the treatment of severe obstructive sleep apnea, Sleep and Breathing. 2011, 15(2): 195-201.

Lam C.L.D., Lam B., Wong M.K.Y., Lu K.H., Au W.Y., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Liang R.H.S., Lam W.K., Ip M.S.M. and Lie A.K.W., Effects of Azithromycin in bronchiolitis obliterans syndrome after hematopoietic SCT-a randomized double-blinded placebo-controlled study, Bone marrow transplantation. 2011, Epub ahead of print.

Lo A.I.L., Huang Y., Lam S.Y., Cheung A.H.K., Au R., Leung C.C., Lam W.K., Ip M.S.M., Chan M.M.W. and Lam B., Early detection of central airway lung cancer in smokers with silicosis, International Journal of Tuberculosis and Lung Disease. 2011, 15(4): 523-527.

Tang S.C.W., Lam B., Lam J.C., Yap D.Y., Ip M.S.M. and Lai K.N., Impact of nephrotic leg edema on OSA: gathering a unifying concept for the pathogenetic role of nocturnal rostral fluid shift, J Am Soc Nephrol. 2010, 21: 417A.

Researcher : Lam CL

Project Title:	The role of nicotinic acetylcholine receptor (nAChR) in bronchial epithelium in relation to lung carcinogenesis
Investigator(s):	Lam CLD, Ip MSM, Tsao GSW, Lam WK
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2010

Project Title:	Establishment of molecular tests for personalized therapy regime for lung cancer
Investigator(s):	Lam CLD, Chan VNY, Ip MSM, Lee VHF
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	09/2010

Project Title:	Therapeutic target gene mutation analysis for newly established lung cancer cell lines from local Chinese patients
Investigator(s):	Lam CLD
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2011

List of Research Outputs

Researcher : Lam CLD

Project Title:	The role of nicotinic acetylcholine receptor (nAChR) in bronchial epithelium in relation to lung carcinogenesis
Investigator(s):	Lam CLD, Ip MSM, Tsao GSW, Lam WK
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2010

Project Title:	Establishment of molecular tests for personalized therapy regime for lung cancer
Investigator(s):	Lam CLD, Chan VNY, Ip MSM, Lee VHF
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	09/2010

Project Title:	Therapeutic target gene mutation analysis for newly established lung cancer cell lines from local Chinese patients
Investigator(s):	Lam CLD
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2011

List of Research Outputs

Chan C.H., Leung V.O.Y., Lam C.L.D., Mak J.C.W., Ip M.S.M., Freeman C. and Shum D.K.Y., Sulfated maltoheptaose is a potential therapeutic in reducing neutrophilic inflammation in a cigarette smoke-induced rat model of chronic obstructive pulmonary disease, American Society for Matrix Biology, 2010 Meeting, Charlecton, SC, USA. Oct 24-27. 2010.

Chan C.H., Lam C.L.D., Mak J.C.W., Ip M.S.M., Freeman C. and Shum D.K.Y., Use of sulfated maltoheptaose to lower neutrophilic inflammation in a rat model of cigarette smoke-induced chronic obstructive pulmonary disease , Sixth International Symposium on Healthy Aging: “A New Golden Age” 5-6 March . 2011.

Ko F.W.S., Ip M.S.M., Chu C.M., So L.K.Y., Lam C.L.D. and Hui D.S.C., Prevalence of allergic rhinitis and its associated morbidity in adults with asthma: a multicentre study. , Hong Kong Medical Journal. 2010, 16(5): 354 - 361.

Lam B., Sam K., Lam C.M., Lai A.Y.K., Lam C.L.D. and Ip M.S.M., The efficacy of oral appliances in the treatment of severe obstructive sleep apnea, Sleep and Breathing. 2011, 15(2): 195-201.

Lam C.L.D., Advances in anti-cholinergics in COPD, Boehringer Ingelheim. 2010.

Lam C.L.D., An unusual patient in the SATURN regime, Roche. 2010.

Lam C.L.D., Certificate Course on Induction of Respiratory Nursing 1. COPD/Asthma: epidemiology, investigation and medical treatment 2. Common Respiratory Disorder: Respiratory Failure, Pneumonia , HK Hospital Authority, HKWC Nursing School. 2010.

Lam C.L.D., Common Respiratory Disorders, Western Medicine for Chinese Medical Practitioners in Tung Wah Group of Hospitals. 2010.

Lam C.L.D., Lam B., Wong M.K.Y., Lu K.H., Au W.Y., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Liang R.H.S., Lam W.K., Ip M.S.M. and Lie A.K.W., Effects of Azithromycin in bronchiolitis obliterans syndrome after hematopoietic SCT-a randomized double-blinded placebo-controlled study, Bone marrow transplantation. 2011, Epub ahead of print.

Lam C.L.D., Fu K.H., Lui M.M.S., Yung P.M., Cheung A.H.K., Lam W.K., Wistuba I.I., Tsao G.S.W., Ip M.S.M. and Minna J.D., Expression of nicotinic acetylcholine receptor in human bronchial epithelium in relation to airflow obstruction, American Thoracic Society Annual Meeting 2011.

Lam C.L.D., Hong Kong Thoracic Society Newsletter, Hong Kong Thoracic Society Newsletter. 2011.

Lam C.L.D., Lung function tests in COPD, Annual Scientific Meeting, Sichuan Respiratory Society and West China University. 2010.

Lam C.L.D., Pharmacotherapy for smoking cessation, HKU Recent advances in the management of lung cancer Symposium and Workshop. 2011.

Lam C.L.D., Lui M.M.S., Lam C.M., Ong L.H.Y., Lam K.S.L. and Ip M.S.M., Prevalence and recognition of obstructive sleep apnea in Chinese patients with type 2 diabetes mellitus, Chest. 2010, 138(5): 1101-1107.

Lam C.L.D., Recent advances in treatment of advanced stage non-small cell lung cancer, Hong Kong-Beijing-Fuzhou Medical Forum. 2011.

Lam C.L.D., Smoking Cessation – pharmacotherapy and impacts on lung cancer, Advances in Management of Lung Cancer: Symposium and Workshop. 2011.

Lam C.L.D., Smoking Cessation – pharmacotherapy and impacts on lung cancer, Advances in management of Lung cancer. 2011.

Researcher : Lam CLK

Project Title:	A Pilot Study on Psychometrics of the Chinese Colorectal Cancer-Specific Functional Assessment of Cancer Therapy-Colorectal (FACT-C) and Quality of Life of Patients with Colorectal Neoplasm
Investigator(s):	Lam CLK, Law WL, Poon JTC
Department:	Med - Family Medicine Unit
Source(s) of Funding:	Small Project Funding
Start Date:	11/2009
Completion Date:	04/2011

Project Title:	Epidemiological Study on Different Body Constitution for the "Treatment of Not Yet ill " Programme.
Investigator(s):	Lam CLK, Wong W
Department:	Med - Family Medicine Unit
Source(s) of Funding:	Hospital Authority - General Award
Start Date:	04/2010

Project Title:	Evaluation Study on Quality of Care of Healthcare Programmes
Investigator(s):	Lam CLK, Lam TP, Chin WY, Chen JY, Lam TP
Department:	Med - Family Medicine Unit
Source(s) of Funding:	Hospital Authority - General Award
Start Date:	04/2010

Project Title:	17th Annual Conference of the International Society for Quality of Life Research (ISOQOL) Is Health Preference Derived from the SF-36v2 Equivalent to that Measured by the SF-6D Health Survey?
Investigator(s):	Lam CLK
Department:	Med - Family Medicine Unit
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	10/2010
Completion Date:	10/2010

Project Title:	A Study on Health-related Quality of Life of patients with Colorectal Neoplasm and Cost-Effectiveness Analysis of Colorectal Cancer Screening in Hong Kong
Investigator(s):	Lam CLK, Poon JTC, McGhee S, Fong DYT
Department:	Family Medicine and Primary Care
Source(s) of Funding:	Health and Health Services Research Fund - Full Grants
Start Date:	12/2010

List of Research Outputs

Fong D.Y.T., Lam C.L.K., Mak K.K., Lo W.S., Lai Y.K., Ho D.S.Y. and Lam T.H., The Short Form-12 Health Survey was a valid instrument in Chinese adolescents., Journal of Clinical Epidemiology. 2010, 63: 1020-1029.

Hung I.F.N., Leung A.Y.M., Chu D.W.S., Leung Y.P., Cheung T..., Chan C.K., Lam C.L.K., Liu S...H..., Chu C...M..., Ho P.L., Chan S.S.C., Lam T.H., Liang R.H.S. and Yuen K.Y., Prevention of acute myocardial infarction and stroke among elderly persons by dual pneumococcal and influenza vaccination: a prospective cohort study, Clinical Infectious Diseases. 2010, 51(9): 1007-1016.

Lai B.M.H., Lam C.L.K. and Kung A.W.C., Validation of the quality of life questionnaire of the European foundation for osteoporosis (QUALEFFO-31) in Chinese, Clinical Rheumatology. 2010, 29(9): 965-72.

Lam C.L.K., Academic Family Medicine-Redefining Academic, Family Practice. 2010, 27: 469-471.

Lam C.L.K., Justice Of The Peace, The Government of the HKSAR. 2010.

Lam C.L.K., Member, Editorial Board, BMC-Family Practice. Biomed Central, 2010.

Lam C.L.K., Member, Editorial Board, BMC-Medical Education. Biomed Central, 2010.

Lam C.L.K., Member, International Editorial Board, Family Practice. 2010.

Lam C.L.K., Plenary lecture on "Quality Primary Care for A11", RACMA-HKCCM Conference. Jointly organized by the Royal Australian College of Medical Administrators and the Hong Kong College of Community Medicine. Hong Kong, 2010.

Lam C.L.K., Wong W. and Lam T.P., Workshop On "cross-cultural Translation And Validation Of Health-related Quality Of Life Measuers", Hong Kong Society for Quality of Life Annual General Meeting, Hong Kong. 2010.

Lam C.L.K., Workshop on "Cross-cultural Translation and Validation of Health-related Quality of Life (HRQOL) Measures", Hong Kong Society for Quality of Life Annual General Meeting. Hong Kong, 2010.

Wong S.K., Lai L.W.C., Chau K.W., Lam C.L.K. and Ng C.H.F., Research Output Prize (Faculty of Architecture), The University of Hong Kong. 2011.

Researcher : Lam CM

List of Research Outputs

Lam B., Sam K., Lam C.M., Lai A.Y.K., Lam C.L.D. and Ip M.S.M., The efficacy of oral appliances in the treatment of severe obstructive sleep apnea, Sleep and Breathing. 2011, 15(2): 195-201.

Lam C.L.D., Lui M.M.S., Lam C.M., Ong L.H.Y., Lam K.S.L. and Ip M.S.M., Prevalence and recognition of obstructive sleep apnea in Chinese patients with type 2 diabetes mellitus, Chest. 2010, 138(5): 1101-1107.

Lam C.M., Lui M.M. and Ip M.S.M., Diabetes and metabolic aspects of OSA, In: McNicholas WT & Bonsignore MR, European Respiratory Monograph - Clinical Handbooks for the Respiratory Professional . European Respiratory Soceity, 2010, Chap 12, No. 50: pp. 189-215.

Researcher : Lam KSL

Project Title:	The Endocrine Society's 88th Annual Meeting Adipocyte Fatty Acid Binding Protein as a Potential Circulating Metabolic Hormone: Clinical and Functional Studies
Investigator(s):	Lam KSL
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	06/2006

Project Title:	Healthy Ageing
Investigator(s):	Lam KSL
Department:	Medicine
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	06/2008
Completion Date:	05/2011

Project Title:	Role of JNK in adipose tissue inflammation, adipokine production and systemic insulin resistance
Investigator(s):	Lam KSL, Xu A, Zhang X
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2009
Completion Date:	06/2011

Project Title:	Adipocyte fatty acid binding protein as a novel mediator of obesity-related fatty liver disease
Investigator(s):	Lam KSL, Xu A
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010

Project Title:	To Establish a Metabolic Study Center in Hong Kong: Focusing on the liver-derived hormones
Investigator(s):	Lam KSL, Xu A, Leung PS, Wang Y, Tso AWK
Department:	Medicine
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2010

Project Title:	Obesity, adipose tissue inflammation and atherosclerosis: role of JNK activation
Investigator(s):	Lam KSL, Xu A
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2011

Project Title:	The 93rd Annual Meeting & Expo (ENDO 2011) Adipocyte Fatty Acid Binding Protein in Kupffer Cell Mediates Obesity-Related Non-Alcoholic Fatty Liver Disease through Endoplasmic Reticulum Stress and Inflammation
Investigator(s):	Lam KSL
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	06/2011

List of Research Outputs

Chang J., Li Y., Huang Y., Lam K.S.L., Hoo R.L.C., Wong W.T., Cheng K.Y., Wang Y., Vanhoutte P.M.G.R. and Xu A., Adiponectin prevents diabetic premature senescence of endothelial progenitor cells and promotes endothelial repair by suppressing the p38 MAP kinase/p16INK4A signaling pathway, Diabetes. 2010, 59: 2949-59.

Chen C., Zhang X., Wong L.C., Chung S.K., Xu A. and Lam K.S.L., Adipose Tissue-specific Suppression Of C-jun Terminal Kinase Attenuates Obesity-related Metabolic Disorders In A Genetic Mouse Model Of Obesity And Type 2 Diabetes, ADA 2011.

Chen C., Tso A.W.K., Cheung B.M.Y., Ong K.L., Wat N.M.S., Edward D J.A.N.U.S., Xu A. and Lam K.S.L., Circulating Pigment Epithelium-Derived Factor Levels and the Risk of Hypertension in a Community-based Study., 16th Medical Research Conference, The University of Hong Kong. 2011.

Chen C., Tso A.W.K., Law S.C., Cheung B.M.Y., Ong K.L., Wat N.M.S., Janus E.D., Xu A. and Lam K.S.L., Plasma Level of Pigment Epithelium-Derived Factor Is Independently Associated with the Development of the Metabolic Syndrome in Chinese Men: A 10-Year Prospective Study. , J Clin Endocrinol Metab.. 2010, 95: 5074-81.

Cheng K.Y., Lam K.S.L., Wang Y., Zhu W., Hoo R.L.C. and Xu A., Transgenic over-expression of APPL1 improves high-fat diet-induced insulin resistance in liver and skeletal muscle., Sixth International Symposium on Healthy Aging: " A New Golden Age”. 2011.. 2011.

Cheng K.Y., Lam K.S.L., Wang Y., Zhu W. and Xu A., Ubiquitination Is Indispensible For The Insulin-sensitizing Activity Of The Adaptor Protein Appl1. 16th Medical Research Conference. , 16th Medical Research Conference 2011. The University of Hong Kong. 2011.

Cheng K.Y., Lam K.S.L., Chen B., Zhu W., Wang Y. and Xu A., 銜接蛋白質APPL1和APPL2對島素敏感性和葡萄糖代謝的陰陽調控 - 從分子機制到生理作用, 2011.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Association of a genetic variant in adrenomedullin gene with its plasma level , Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Cheung B.M.Y., Ong K.L., Jiang C.Q., Liu B., Jin Y.L., Tso A.W.K., Tam S., Wong K.S., Tomlinson B., Lin J.M., Yue X.J., Lam K.S.L., Lam T.H. and Thomas G.N., Association of a genetic variant in the apolipoprotein A5 gene with the metabolic syndrome in Chinese, Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Cheung B.M.Y., Ong K.L., Xu A., Lam T.H. and Lam K.S.L., Association of genetic variants in gene encoding lipocalin-2 with plasma alanine aminotransferase and aspartate aminotransferase, Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Gamma-glutamyl transaminase level predicts the development of hypertension., Poster Presentation at the 23rd Scientific Meeting of the International Society of Hypertension, Vancouver. 2010.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Gamma-glutamyl transferase level predicts the development of hypertension in Hong Kong Chinese, Clin Chim Acta. 2011, 412(15-16): 1326-1331.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Lam T.H. and Lam K.S.L., Increasing prevalence of hypertension and central obesity in the Hong Kong cardiovascular risk factor prevalence study, Basic & Clinical Pharmacology & Toxicology. Presented at the 10th Congress of the European Association for Clinical Pharmacology and Therapeutics, Budapest. 2011, 109 (Suppl. 1): 108.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Lam T.H. and Lam K.S.L., Increasing prevalence of hypertension in Hong Kong Cardiovascular Risk Factor Prevalence Study: Role of general and central obesity, Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Cheung B.M.Y. and Lam K.S.L., Is intensive LDL-cholesterol lowering beneficial and safe?, Lancet. 2010, 376(9753): 1622-1624.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Thomas G.N., Lam T.H. and Lam K.S.L., Mendelian randomisation analysis suggests that plasma interleukin-6 is raised in hypertension but does not cause its development, Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Plasma adrenomedullin level is related to plasma interleukin-6 and a polymorphism in the adrenomedullin gene, Basic & Clinical Pharmacology & Toxicology. Presented at the 10th Congress of the European Association for Clinical Pharmacology and Therapeutics, Budapest. 2011, 109 (Suppl. 1): 102-103.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Role of genetic variants in gene encoding lipocalin-2 in the development of elevated blood pressure, Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Lam K.S.L., Cherny S.S. and Sham P.C., Using glycosylated haemoglobin to define the metabolic syndrome in United States adults, Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Lam K.S.L., Cherny S.S. and Sham P.C., Using glycosylated hemoglobin to define the metabolic syndrome in United States adults. , Oral Presentation at the 23rd Scientific Meeting of the International Society of Hypertension, Vancouver. 2010.

Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Ong K.L., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., Genetic variants associated with persistent central obesity and the metabolic syndrome in a 12-year longitudinal study, Euro J Endocrinol . 2011, 164: 381-8.

Chu L.W., Tam S., Wong L.C., Yik P.Y., Song Y., Cheung B.M.Y., Morley J.E. and Lam K.S.L., Bioavailable Testosterone Predicts a Lower Risk of Alzheimer's Disease in Older Men, J Alzheimers Dis. 2010, 21(4): 1335-1345.

Ge X., Chen C., Hui X., Wang Y., Lam K.S.L. and Xu A., Fibroblast Growth Factor-21 Promotes Glucose Uptake through Activation of the serum response factor (SRF)/ Ets-like protein-1 (Elk-1) signaling cascade in Adipocytes, ADA 2011.

Hoo R.L.C., Wong Y.L., Xu A. and Lam K.S.L., The role of fatty acid binding protein in the pathogenesis of obesity-related inflammatory diseases, Research centre of heart, brain and healthy aging. 2011.

Hoo R.L.C., Wong Y.L., Qiao C.F., Xu A., Xu H.X. and Lam K.S.L., he effective fraction isolated from Radix Astragali alleviates glucose intolerance, insulin resistance and hypertriglyceridemia in db/db diabetic mice through its anti-inflammatory activity, Nutr Metab. 2010, 7: 67.

Lam C.L.D., Lui M.M.S., Lam C.M., Ong L.H.Y., Lam K.S.L. and Ip M.S.M., Prevalence and recognition of obstructive sleep apnea in Chinese patients with type 2 diabetes mellitus, Chest. 2010, 138(5): 1101-1107.

Lam J.K., Lam C.W., Kung A.W.C., Tan K.C.B., Lau K.S. and Lam K.S.L., A man with hypophosphataemia, BMJ. 2011, 342:d773.

Lam J.K.Y., Lam K.S.L., Kung A.W.C., Tan K.C.B., Chow W.S. and Tso A.W.K., A woman with raised alkaline phosphatase and forearm deformity, BMJ. 2011, 342: d3435.

Lam K.S.L., Hoo R.L.C., Wong Y.L. and Xu A., Adipocyte fatty acid binding protein in Kupffer cell mediates non alcoholic fatty liver disease through endoplasmic reticulum stresss and inflammation, Endocrine society meeting 2011.

Lam K.S.L., Adipocyte-FABP as a novel biomarker predicting the development of cardiometabolic diseases, Cardiovascular and Metabolic Disease Leaders Summit, Beijing, China. 2010.

Lam K.S.L., Associate Editor, Chinese Journal of Endocrinology and Metabolism. 2010.

Lam K.S.L., Fibroblast growth factor 21 as a novel metabolic hormone integrating the circadian rhythm with energy homeostasis in man, The 6th Scientific Meeting of the Asia-Pacific Diabetes and Obesity Study Group, Singapore. 2010.

Lam K.S.L., Incretin and islet biology: Basic science within Merck, Asia Islet Biology & Incretin symposium, Kyoto, Japan. 2010.

Lam K.S.L., Update on the pathophysiology and genetics of diabetes, Annual Scientific Meeting of the Hong Kong Society of Clinical Chemistry. 2011.

Law L.S.C., Tso A.W.K., Tam S., Wat N.M.S., Cheung B.M.Y. and Lam K.S.L., Haemoglobin A1c is superior to fasting glucose in predicting the incidence of diabetes over 8 years among Chinese, Diabetes Res Clin Pract. 2010, 91(2): e53-6.

Lee A.M., Chu L.W., Chong C.S., Chan S.Y., Tam S., Lam K.S.L. and Lam T.P., Relationship between symptoms of androgen deficiency and psychological factors and quality of life among Chinese men, Int J Androl. 2010, 33(5): 755-63.

Leung T.M., Khong P.L. and Lam K.S.L., Prevalence and factors associated with brown adipose tissue detected by 18F-FDG PET/CT in Hong Kong Chinese, SNM 2011 Annual Meeting, San Antonio, Texas, USA. 4-8 June 2011.

Li F.Y.L., Cheng K.Y., Lam K.S.L., Vanhoutte P.M.G.R. and Xu A., Cross-talk Between Adipose Tissue And Vasculature: Role Of Adiponectin, Acta Physiologica. 2010.

Li F.Y.L., Wang Y., Xiao Y., Lam K.S.L. and Xu A., Endothelial-specific Activation Of Amp-activated Protein Kinase Improves Impairment In Endothelial Repair In Type 1 Diabetic Mice, Sixth International Symposium on Healthy Aging: “A New Golden Age”. 2011.

Li F.Y.L., Wang Y., Lam K.S.L. and Xu A., Endothelium-specific activation of AMP-activated protein kinase alleviates diabetes-induced impairment in endothelial repair in mice, 16th Medical Research Conference. 2011.

Li F.Y.L., Hoo R.L.C., Lam K.S.L. and Xu A., Outstanding Scientific Work – Winning poster presentation , Frontiers in Cardiovascular Biology; European Society of Cardiology. 2010.

Li F.Y.L., Hoo R.L.C., Lam K.S.L. and Xu A., Toll-like receptor 4 inactivation alleviates impaired vascular reendothelialisation by improving endothelial progenitor cell adhesion, In: Hans Michael Piper, Journal of Cardiovascular Research. United Kingdom, Oxford Journals, 2010, 87: S48.

Li M., Ho J.C.Y., Lai K.W.H., Au K.W., Xu A., Cheung B.M.Y., Lam K.S.L. and Tse H.F., Hypoadiponectinemia and its Impact on circulating endothelial progenitor cells in patients with type 2 diabetes - adiponectin and endothelial progenitor cells, Diabetes/Metab Res Rev. 2010, 27: 185-94.

Li M., Ho J.C.Y., Lai K.W.H., Au K.W., Xu A., Cheung B.M.Y., Lam K.S.L. and Tse H.F., The decrement in circulating endothelial progenitor cells (EPCs) in type 2 diabetes is independent of the severity of the hypoadiponectemia, Diabetes Metab Res Rev. 2011, 27(2): 185-194.

Liu J., Xu A., Lam K.S.L. and Wang Y., Deficiency of Adiponectin, a Hormone Selectively Secreted from Fat Cells, Accelerated Breast Cancer Development and Promoted Cholesterol Accumulation in Mammary Tumors of MMTV-Polyomavirus Meiddle T Antigen Mice, 15th Research Postgraduate Symposium, Hong Kong, December 1-2, 2010. 230.

Liu J., Zu Y., Lam K.S.L., Lee M.Y.K., Vanhoutte P.M.G.R., Xu A. and Wang Y., SIRT1 Promotes Proliferation and Prevents Senescence Through Targeting LKB1 in Primary Porcine Aorteic Endothelial Cells, 15th Research Postgraduate Symposium, Hong Kong, December 1-2, 2010. 184.

Michele Y.U.E.N., Wing Sun C.H.O.W., Chen C., Ting Chung P.U.N., Law S.C., Tso A.W.K., Xu A. and Lam K.S.L., . Circulating Plasma Pigment Epithelium-Derived Factor (PEDF) Levels Are Associated with Insulin Resistance in Women with Estrogen Deficiency, 71th American Diabetes Association Scientific Sessions, San Diego, CA. 2011.

Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Lam T.H., Cheung B.M.Y. and Lam K.S.L., A genetic variant in the gene encoding adrenomedullin predicts the development of dysglycemia over 6.4 years in Chinese, Clin Chim Acta. 2010, 412: 353-7.

Ong K.L., Cheung B.M.Y., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Association of a genetic variant in adrenomedullin gene with its plasma level., Oral Presentation at the Annual Scientific Meeting of the Hong Kong Society of Endocrinology, Metabolism and Reproduction, Hong Kong. 2010.

Ong K.L., Jiang C.Q., Liu B., Jin Y.L., Tso A.W.K., Tam S., Wong K.S., Tomlinson B., Cheung B.M.Y., Lin J.M., Yue X.J., Lam K.S.L., Lam T.H. and Thomas G.N., Association of a genetic variant in the apolipoprotein A5 gene with the metabolic syndrome in Chinese, Clin Endocrinol (Oxf). 2010, 74: 206-13.

Ong K.L., Li M., Tso A.W.K., Xu A., Cherny S.S., Sham P.C., Tse H.F., Lam T.H., Cheung B.M.Y. and Lam K.S.L., Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese. , European Journal of Endocrinology. 2010, 163: 251-257.

Ong K.L., Tso A.W.K., Lam K.S.L., Cherny S.S., Sham P.C. and Cheung B.M.Y., Using glycosylated hemoglobin to define the metabolic syndrome in United States adults, Diabetes Care. 2010, 23: 1856-8.

Tso A.W.K., Lam T.K.Y., Xu A., Yiu K.H., Tse H.F., Li L.S.W., Law S.C., Cheung B.M.Y., Cheung R.T.F. and Lam K.S.L., Serum adipocyte fatty acid-binding protein is associated with ischemic stroke and early death, Neurology. 2011, 76(23): 1968-75.

Wang Y., Xu C., Vanhoutte P.M.G.R., Lam K.S.L. and Xu A., Modulation of SIRT1 activity in adipose tissue alters systemic energy homeostasis and insulin sensitivity, American Diabetes Association 71th Scientific Sessions. 2011.

Xu A., Wang Y., Lam K.S.L. and Vanhoutte P.M.G.R., Vascular actions of adipokines molecular mechanisms and therapeutic implications, Adv Pharmacol. 2010, 60: 229-55.

Xu A., Wang Y., Lam K.S.L. and Vanhoutte P.M.G.R., Vascular actions of adipokines: Molecular mechanisms and therapeutic implications., Advances in Pharmacology. 2010, 60: 229-255.

Ye D., Li F.Y.L., Lam K.S.L., Wang Y. and Xu A., Genetic Inactivation of Toll-Like Receptor 4 Alleviates Diet-induced Nonalcoholic Steatohepatitis by Inhibiting Reactive Oxygen Species-evoked Activation of X-box Binding Protein-1 in ApoE-deficient Mice, ADA 2011.

Yu H., Xia F., Lam K.S.L., Wang Y., Bao Y., Zhang J., Gu Y., Zhou P., Lu J., Jai W. and Xu A., Circadian Rhythm of Circulating Fibroblast Growth Factor 21 (FGF21) is Related to Diurnal Changes in Free Fatty Acids in Humans., Clinical Chemistry. 2011.

Yuen M.M.A., Tam T.C.C., Lau W.W.Y., Chan J.F.W., Chow W.S. and Lam K.S.L., An unforeseen complication of urinary trail infection in a diabetic patient, BMJ. 2010, 341: c3073.

Zhang X., Lam K.S.L., Ye H., Chung S.K., Zhou M., Wang Y. and Xu A., Adipose tissue-specific inhibition of hypoxia-inducible factor 1{alpha} induces obesity and glucose intolerance by impeding energy expenditure in mice, J Biol Chem. 2010, 285: 32869-77.

Zhang X., Xu A., Chung S.K., Cresser J.H., Sweeney G., Wong L.C., Lin A. and Lam K.S.L., Selective inactivation of c-Jun NH2-terminal kinase in adipose tissue protects against diet-induced obesity and improves insulin sensitivity in both liver and skeletal muscle in mice, Diabetes . 2011, 60: 486-95.

Zhou L., Chu L.W., Kwan S.C., Lam K.S.L., Ho W.L., Ho W.M. and Chan K.H., Plasma amyloid beta peptides and oligomers antibodies in Alzheimer's disease, 16th Medical Research Conference, Department of Medicine, The University of Hong Kong, 2011. Hong Kong Medical Journal . 2011, 17 (Supplement 1): 69.

Zhou L., Chu L.W., Kwan S.C., Lam K.S.L., Ho W.L., Ho W.M. and Chan K.H., Plasma amyloid beta peptides and oligomers levels in Alzheimer's disease, 16th Medical Research Conference, Department of Medicine, The University of Hong Kong, 2011. Hong Kong Medical Journal. 2011, 17 (Supplement 1): 69.

Zhou L., Chu L.W., Kwan S.C., Lam K.S.L., Ho W.L., Ho W.M. and Chan K.H., Plasma beta-amyloid peptides and serum associated beta-amyloid autoantibodies in patients with Alzheimer's disease, Alzheimer's Disease Conference 2011: From Public Health, Basci And Clinical Sciences To Therapeutic Insights. 2011.

Zhou L., Chu L.W., Kwan S.C., Lam K.S.L., Ho W.L., Ho W.M. and Chan K.H., Plasma b-amyloid Peptides And Serum Associated b-amyloid Autoantibodies In Alzheimer's Disease, Sixth International Symposium On Healthy Aging. 2011.

Zhou M., Xu A., Lam K.S.L., Tam P.K.H., Che C.M., Chan L., Lee I.K., Wu D.H. and Wang Y., Rosiglitazone promotes fatty acyl CoA accumulation and excessive glycogen storage in livers of mice without adiponectin, Journal of Hepatology. 2010, 53(6): 1108-1116.

Zhu W., Cheng K.Y., Chen B., Wang Y., Lam K.S.L. and Xu A., APPL2 inhibits insulin-stimulated glucose uptake through both Akt and its downstream target TBC1D1 in skeletal muscle, 16th Medical Research Conference. The University of Hong Kong, Hong Kong. . 2011.

Researcher : Lam MF

List of Research Outputs

Cheung C.Y., Lam M.F., Lee K.C., Chan G.S.W., Chan K.W., Chau K.F., Li C.S., Chan D.T.M. and Lai K.N., Renal cell carcinoma of native kidney in Chinese renal transplant recipients: a report of 12 cases and a review of the literature, International Urology and Nephrology. 2011, 43(3): 675-80.

Huang W., Gu H., Li R., Lou T., Zhang J., Shi W., Ye Z., Zhou Y., Li C., Xiong S., Li L., Wu C., Leung J.C.K., Lam M.F., Lai K.N. and Wang A.Y.M., Association of -27T>C and its haplotype at the putative promoter for IgA-specific receptor gene with IgA nephropathy among the Chinese Han population, Nephrology Dialysis Transplantation. 2011, 26(8): 2537-44.

Yap D.Y., Ma M.K., Lai A.S., Chan S.Y., Seto W.K., Lam M.F., Chan D.T.M. and Lai K.N., Superior mesenteric artery syndrome complicating dialysis patients with peritoneal failure-report of 3 cases, Clinical Nephrology. 2011, 75 Suppl 1: 37-41.

Yip T.P.S., Tse K.C., Ng F.S.K., Hung I.F.N., Lam M.F., Tang S.C.W., Lui S.L., Lai K.N., Chan D.T.M. and Lo W.K., Clinical course and outcomes of single-organism Enterococcus peritonitis in dialysis patients, Peritoneal Dialysis International. 2011, 31.

Researcher : Lam S.C.

List of Research Outputs

Zhang W..., Wang J..., Zou B..., Sardet C..., Li J..., Lam S...C..., Ng L..., Pang R...W...C..., Hung I...F...N..., Tan V...P...Y..., Jiang B... and Wong B...C...Y..., Four and a half LIM protein 2 (FHL2) negatively regulates the transcription of E-cadherin through interaction with Snail1, European Journal of Cancer. 2011, 47(1): 121-130.

Zhang W..., Yang Y..., Jiang B..., Peng J., Tu S..., Sardet C..., Zhang Y..., Pang R...W...C..., Hung I...F...N..., Tan V...P...Y..., Lam S...C..., Wang J... and Wong B...C...Y..., XIAP-associated factor 1 interacts with and attenuates the trans-activity of four and a half LIM protein 2, Molecular Carcinogenesis. 2010, 50: 199-207.

Researcher : Lam SC

List of Research Outputs

Ma J., Wang J., Zhang W., Zou B., Chen W., Lam S.C., Chen M., Pang R.W.C., Tan V.P.Y., Hung I.F.N., Lan H.Y., Wang Q. and Wong B.C.Y., Promoter hypermethylation and histone hypoacetylation contribute to Pancreatic-duodenal homeobox 1 (PDX1) silencing in gastric cancer., Carcinogenesis. 2010, 31(9): 1552-60.

Zhang W., Jiang B., Guo Z., Sardet C., Zou B., Lam S.C., Li J., He M., Lan H.Y., Pang R.W.C., Hung I.F.N., Tan V.P.Y., Wang J. and Wong B.C.Y., Four-and-a-half LIM protein 2 promotes invasive potential and epithelial-mesenchymal transition in colon cancer., Carcinogenesis. 2010, 31: 1220-9.

Zou B., Chim J.C.S., Pang R.W.C., Zeng H.U.I., Dai Y., Zhang R., Lam S.C., Tan V.P.Y., Hung I.F.N. and Lan H.Y., XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification, Mol Carcinog. 2011.

Zou B., Chim J.C.S., Pang R.W.C., Zeng H.U.I., Dai Y., Zhang R., Lam S.C., Tan V.P.Y., Hung I.F.N., Lan H.Y. and Wong B.C.Y., XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification, Molecular Carcinogenesis. 2010, under review.

Researcher : Lam SC

List of Research Outputs

Researcher : Lam SK

Project Title:	Biotech Company in the Faculty of Medicine, The University of Hong Kong
Investigator(s):	Lam SK
Department:	Medicine
Source(s) of Funding:	The University of Hong Kong Foundation Seed Grant
Start Date:	07/2003

Project Title:	Treatment of gastrointestinal cancer by targeting survivin using adeno-associated virus gene delivery system
Investigator(s):	Lam SK, Wong BCY, Lin MC
Department:	Medical Faculty
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2004

Researcher : Lam SK

List of Research Outputs

Lam S.K. and Ng T.B., Lectins: production and practical applications, In: Alexander Steinbüchel, Applied microbiology and biotechnology. Springer, 2011, 89: 45-55.

Researcher : Lam TP

Project Title:	Attitudes, beliefs and knowledge concerning antibiotic use and resistance of the general public in Hong Kong: combined qualitative and quantitative study
Investigator(s):	Lam TP, Lam KF, Ho PL
Department:	Med - Family Medicine Unit
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	08/2009

Project Title:	Primary care physicians’ attitudes towards people with mental health problems in Hong Kong
Investigator(s):	Lam TP, Lam KF, Lam WW
Department:	Med - Family Medicine Unit
Source(s) of Funding:	Small Project Funding
Start Date:	12/2009

Project Title:	What are the facilitators and obstacles to promote mental health help-seeking in primary care? – views of family physicians and psychiatrists
Investigator(s):	Lam TP, Lo TL, Lam KF
Department:	Med - Family Medicine Unit
Source(s) of Funding:	Small Project Funding
Start Date:	04/2011

List of Research Outputs

Lam C.L.K., Wong W. and Lam T.P., Workshop On "cross-cultural Translation And Validation Of Health-related Quality Of Life Measuers", Hong Kong Society for Quality of Life Annual General Meeting, Hong Kong. 2010.

Lam T.P., Co-Editor of Asia Pacific Family Medicine-the Official Journal of Wonca Asia Pacific. 2011.

Lam T.P., Regional Editor of Journal of Evaluation and Clinical Practice. 2011.

Researcher : Lam TP

List of Research Outputs

Lam T.P., Co-Editor of Asia Pacific Family Medicine-the Official Journal of Wonca Asia Pacific. 2011.

Lam T.P., Regional Editor of Journal of Evaluation and Clinical Practice. 2011.

Researcher : Lam WK

List of Research Outputs

Lam B., Wong M.K.Y., Lu K.H., Au W.Y., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Liang R.H.S., Lam W.K., Ip M.S.M. and Lie A.K.W., Effects of Azithromycin in bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation – a randomized double-blinded placebo-controlled study, Bone Marrow Transplantation. 2011, Epub ahead of print.

Lam C.L.D., Lam B., Wong M.K.Y., Lu K.H., Au W.Y., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Liang R.H.S., Lam W.K., Ip M.S.M. and Lie A.K.W., Effects of Azithromycin in bronchiolitis obliterans syndrome after hematopoietic SCT-a randomized double-blinded placebo-controlled study, Bone marrow transplantation. 2011, Epub ahead of print.

Lam C.L.D., Fu K.H., Lui M.M.S., Yung P.M., Cheung A.H.K., Lam W.K., Wistuba I.I., Tsao G.S.W., Ip M.S.M. and Minna J.D., Expression of nicotinic acetylcholine receptor in human bronchial epithelium in relation to airflow obstruction, American Thoracic Society Annual Meeting 2011.

Lo A.I.L., Huang Y., Lam S.Y., Cheung A.H.K., Au R., Leung C.C., Lam W.K., Ip M.S.M., Chan M.M.W. and Lam B., Early detection of central airway lung cancer in smokers with silicosis, International Journal of Tuberculosis and Lung Disease. 2011, 15(4): 523-527.

Researcher : Lan HY

Project Title:	Essential role of SMAD3 in cardiac repair and fibrosis
Investigator(s):	Lan HY
Department:	Medicine
Source(s) of Funding:	Sun Chieh Yeh Heart Foundation - General Award
Start Date:	08/2006

Project Title:	Role of Smad signalling in the pathogenesis of hypertensive nephropathy and a novel therapeutic potential using ultrasound-microbubble-mediated transfer of inducible Smad7
Investigator(s):	Lan HY
Department:	Medicine
Source(s) of Funding:	Baxter Health Care Ltd. - General Award
Start Date:	05/2008

Project Title:	Gene therapy for diabetic nephropathy using ultrasound-microbubble-mediated transfer of inducible smad7
Investigator(s):	Lan HY
Department:	Medicine
Source(s) of Funding:	Pharmaceutical Industry - General Award
Start Date:	05/2008

List of Research Outputs

Ma J., Wang J., Zhang W., Zou B., Chen W., Lam S.C., Chen M., Pang R.W.C., Tan V.P.Y., Hung I.F.N., Lan H.Y., Wang Q. and Wong B.C.Y., Promoter hypermethylation and histone hypoacetylation contribute to Pancreatic-duodenal homeobox 1 (PDX1) silencing in gastric cancer., Carcinogenesis. 2010, 31(9): 1552-60.

Tang S.C.W., Chan Y.Y., Leung J.C.K., Cheng A.S., Lan H.Y. and Lai K.N., Additive Renoprotective Effects Of B2-kinin Receptor Blocker And PPAR-y Agonist In Uninephrectomized Db/db Mice [journal Impact Factor 4.602] (in Press), Lab Invest . 2011, 91(9): 1351-62.

Tang S.C.W., Chan Y.Y., Leung J.C.K., Cheng A.S., Lin M., Lan H.Y. and Lai K.N., Differential effects of advanced glycation end-products on renal tubular cell inflammation, Nephrology (Carlton, Vic). 2011, 16(4): 417-25.

Yang F., Huang X.R., Chung A.C., Hou C.C., Lai K.N. and Lan H.Y., Essential role for Smad3 in angiotensin II-induced tubular epithelial-mesenchymal transition, J Pathol. 2010, 221(4): 390-401.

Zhang W., Jiang B., Guo Z., Sardet C., Zou B., Lam S.C., Li J., He M., Lan H.Y., Pang R.W.C., Hung I.F.N., Tan V.P.Y., Wang J. and Wong B.C.Y., Four-and-a-half LIM protein 2 promotes invasive potential and epithelial-mesenchymal transition in colon cancer., Carcinogenesis. 2010, 31: 1220-9.

Zou B., Chim J.C.S., Pang R.W.C., Zeng H.U.I., Dai Y., Zhang R., Lam S.C., Tan V.P.Y., Hung I.F.N. and Lan H.Y., XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification, Mol Carcinog. 2011.

Zou B., Chim J.C.S., Pang R.W.C., Zeng H.U.I., Dai Y., Zhang R., Lam S.C., Tan V.P.Y., Hung I.F.N., Lan H.Y. and Wong B.C.Y., XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification, Molecular Carcinogenesis. 2010, under review.

Researcher : Lan XR

Project Title:	Mechanisms of Peritoneal Fibrosis: Role of TGF-beta Signaling
Investigator(s):	Lan XR, Lan HY, Leung JCK
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2008

Researcher : Lau CP

Project Title:	Evaluation of the antianginal efficacy and safety of oral chronic administration of ivabradine (5mg b.i.d. then 7.5mg b.i.d or 10mg b.i.d) compared to atenolol (50mg o.d then 100mg o.d), in patients with stable effort angina pectorals
Investigator(s):	Lau CP, Lee KLF
Department:	Medicine
Source(s) of Funding:	Other Funding Scheme
Start Date:	05/2000

Project Title:	Roles of macrophage migration inhibitory factor (MIF) in acute myocardial infarction
Investigator(s):	Lau CP, Yu CM, Lan HY
Department:	Medicine
Source(s) of Funding:	Low Budget High Impact Programme
Start Date:	11/2000

List of Research Outputs

Chan H.T., So J., Li S.W., Siu D.C.W., Lau C.P. and Tse H.F., J Cardiovasc Pharmacol, Effect of herbal consumption on clinical efficacy of warfarin therapy in patients with atrial fibrillation. 2011.

Chan Y.H., Siu D.C.W., Li L.S.W., Lam T.H., Lau C.P. and Tse H.F., Abnormal Vascular Function In Pr Interval Prolongation: Novel Insights Into Mechanisms Of Adverse Cardiovascular Outcomes (Abstract and Oral Presentation), 3rd Asian Preventive Cardiology & Cardiac Rehabilitation Conference cum 8th Certificate Course in Cardiac Rehabilitation, 11-14 December 2010, Hong Kong. Hong Kong, Hong Kong College of Cardiology, 2010.

Chan Y.H., Lam T.H., Lau K.K., Yiu K.H., Siu D.C.W., Li S.W., Chan H.T., Tam S., Lau C.P. and Tse H.F., Dietary Intake of Phytoestrogen is Associated with Increased Circulating Endothelial Progenitor Cells in Patients with Cardiovascular Disease, European Journal of Cardiovascular Prevention and Rehabilitation. 2010.

Chan Y.H., Lam T.H., Lau G.K.K., Yiu K.H., Siu D.C.W., Li L.S.W., Chan K.H.T., Tam S., Lau C.P. and Tse H.F., Dietary intake of phytoestrogen is associated with increased circulating endothelial progenitor cells in patients with cardiovascular disease, European Journal of Cardiovascular Prevention and Rehabilitation. 2011, 18(3): 360-368.

Ho L.Y., Siu D.C.W., Yue W., Lau C.P., Lip G.Y. and Tse H.F., Safety and efficacy of oral anticoagulation therapy in Chinese patients with concomitant atrial fibrillation and hypertension, Journal of Human Hypertension. 2010, Epub.

Lau C.P. and Tse H.F., The importance of pacing site to prevent heart failure and atrial fibrillation in CRT/bradycardia, The 4th Qianjiang International Cardiovascular Conference, China.. 2010.

Lau C.P. and Tse H.F., The importance of pacing site to prevent heart failure and atrial fibrillation in CRT/bradycardia, The 4th Qianjiang International Cardiovascular Conference, China. 2010.

Siu D.C.W., Jim M.H., Lau C.P. and Tse H.F., Acute Cardiac Care, Thromborprophylaxis in patients with acute atrial fibrillation. 2011.

Siu D.C.W., Yiu K.H., Lee K.L.F., Yan G., Lee S.W.L., Lau C.P. and Tse H.F., Effects of Right Low Atrial Septal versus Right Atrial Appendage Pacing on Atrial Mechanical Function and Dyssynchrony in Patients with Sinus Node Dysfunction and Paroxysmal Atrial Fibrillation, European Journal of Echocardiography. 2010, 11: 672.

Siu D.C.W., Yan G., Yue W., Lee K.L.F., Lee S.W.L., Lau C.P. and Tse H.F., Effects of right low atrial septal versus right atrial appendage pacing on atrial mechanical function and dyssynchrony in patients with sinus node dysfunction and paroxysmal atrial fibrillation , Heart Rhythm. 2011.

Siu D.C.W., Yiu K.H., Yan G., Yue W., Lee K.L.F., Lee S.W.L., Lau C.P. and Tse H.F., Effects of right low atrial septal versus right atrial appendage pacing on atrial mechanical function and dyssynchrony in patients with sinus node dysfunction and paroxysmal atrial fibrillation, European Society of Echocardiogram. 2010.

Siu D.C.W., Lee K.L.F., Yue W., Yan G., Lee S.W.L., Lau C.P. and Tse H.F., Effects of right low atrial septal versus right atrial appendage pacing on strial mechanical function and dyssynchrony in patients with sinus node dysfunction and paroxysmal atrial fibrillation. , Heart Rhythm. 2011.

Tao R., Sun H., Lau C.P., Tse H.F., Lee H.C. and Li G.R., Cyclic ADP ribose is a novel regulator of intracellular Ca(2+) oscillations in human bone marrow mesenchymal stem cells. , J Cell Mol Med. 2011, 15(12): 2684-96.

Wang M.M., Siu D.C.W., Yan G., Yue W., Lee K.L.F., Lee S.W.L., Lau C.P. and Tse H.F., Effects of right low atrial septal versus right atrial appendage pacing on atrial mechanical function and dyssynchrony in patients with sinus node dysfunction and paroxysmal atrial fibrillation , Heart Rhythm. 2011.

Wu H., Wu W., Lau C.P., Vanhoutte P.M.G.R. and Li G.R., Use-dependent block of hKv1.5 channels and the molecular determinant by the natural flavone acacetin, 16th Medical Research Conference, Department of Medicine, HKU. 2011, 17(1): 60.

Wu W., Lau C.P., Tse H.F. and Li G.R., Beta1 subunit-dependent modulation of BK channel by membrane cholesterol, J HK Coll Cardiol. 2010. 18(2): 65.

Wu W., Lau C.P., Tse H.F. and Li G.R., Effects of increased cholesterol level on BK channels, 16th Medical Research Conference, Department of Medicine, HKU. 2011, 17(1): 61.

Yiu K.H., Pong V., Siu D.C.W., Lau C.P. and Tse H.F., Cardiovasc Diabetol, Long-term oral nitrate therpy is assoicated with adverse outcome in diabetic patients after elective percutaneous coronary intervention.. 2011, 10(1): 52.

Yiu Y.F., Chan Y.H., Yiu K.H., Siu D.C.W., Chan H.T., Li S.W., Wong L.Y., Tam S., Lau C.P. and Tse H.F., Vitamin D Deficiency Is Associated With Depletion Of Circulating Endothelial Progenitor Cells And Endothelial Dysfunction In Patients With Type II Diabetes, European Society of Cardiology Annual Congress 2010. European Heart Journal (Supp) 2010 P4690, 2010 . 2010.

Zhang Y., Lau C.P., Tse H.F. and Li G.R., Expression of TrpC and TrpM channels in human atrial myocytes, J HK Coll Cardiol. 2010. 18(2): 71.

Zhang Y., Lau C.P. and Li G., Human cardiac Kv4.3 channels are regulated by EGFR kinase and Src-family kinases., International Academy of Cardiology 15th World Congress on Heart Disease Annual Scientific Sessions, Vancouver, BC, Canada; July 24-27, 2010.. 2010.

Zhang Y., Sun H., Tse H.F., Lau C.P. and Li G.R., Identification of transient receptor potential channels in human atrial myocytes, 16th Medical Research Conference, Department of Medicine, HKU. 2011, 17(1): 68.

Researcher : Lau G

Project Title:	Prevalence and Natural History of Non-Alcoholic Fatty Liver Diseases in Hong Kong Chinese
Investigator(s):	Lau G
Department:	Medicine
Source(s) of Funding:	Hong Kong Liver Foundation - General Award
Start Date:	02/2005

Project Title:	Basic science study on the disease mechanism, clinical surveillance and outcomes of severe hepatitis B infection
Investigator(s):	Lau G
Department:	Medicine
Source(s) of Funding:	Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:	12/2007

List of Research Outputs

Chen L., Ho D.W.Y., Lee N.P.Y., Sun S., Lam B.H., Wong K.F., Yi X., Lau G., Ng E.W.Y., Poon T.C.W., Lai P.B.S., Cai Z., Peng J., Leng X., Poon R.T.P. and Luk J.M.C., Enhanced detection of early hepatocellular carcinoma by serum SELDI-TOF proteomic signature combined with alpha-fetoprotein marker, Annals of Surgical Oncology. 2010, 17(9): 2518-2525.

Cheung C.K.Y., Lo C.M., Man K. and Lau G., Occult hepatitis B virus infection of donor and recipient origin after liver transplantation despite nucleoside analogue prophylaxis, Liver Transplantation. 2010, 16(11): 1314-1323.

Researcher : Lau GKK

Project Title:	Prevalence and Natural History of Non-Alcoholic Fatty Liver Diseases in Hong Kong Chinese
Investigator(s):	Lau G
Department:	Medicine
Source(s) of Funding:	Hong Kong Liver Foundation - General Award
Start Date:	02/2005

Project Title:	Basic science study on the disease mechanism, clinical surveillance and outcomes of severe hepatitis B infection
Investigator(s):	Lau G
Department:	Medicine
Source(s) of Funding:	Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:	12/2007

List of Research Outputs

Chan Y.H., Lam T.H., Lau G.K.K., Yiu K.H., Siu D.C.W., Li L.S.W., Chan K.H.T., Tam S., Lau C.P. and Tse H.F., Dietary intake of phytoestrogen is associated with increased circulating endothelial progenitor cells in patients with cardiovascular disease, European Journal of Cardiovascular Prevention and Rehabilitation. 2011, 18(3): 360-368.

Researcher : Lau GKK

List of Research Outputs

Researcher : Lau KS

List of Research Outputs

Dai Z., Chung S.K., Miao D., Lau K.S., Chan A.W.H. and Kung A.W.C., Sodium/myo-inositol cotransporter 1 and myo-inositol are essential for osteogenesis and bone formation, Journal of Bone and Mineral Research. 2011, 26(3): 582-590.

Lam J.K., Lam C.W., Kung A.W.C., Tan K.C.B., Lau K.S. and Lam K.S.L., A man with hypophosphataemia, BMJ. 2011, 342:d773.

Li H.Y., Cheung C.L., Xiao S., Lau K.S., Gao Y., Bow C.H.Y., Huang Q.Y., Sham P.C. and Kung A.W.C., Identification Of Qtl Genes For Bmd Variation Using Both Linkage And Gene-based Association Approaches., Human Genetics. 2011.

Xiao S., Cherny S.S., Li H.Y., Gao Y., Tso H.W., Lau K.S., Luk K.D.K., Sham P.C. and Kung A.W.C., Association Of Jag1 Gene And Its Variant Sequence With Bone Mineral Density And Osteoporotic Fractures: A Genome-wide Association Study And Follow-up Replication Studies, The HKSEMR Annual Scientific Meeting and Annual General Meeting, 21 November, Hong Kong. 2010.

Xiao S., Gao Y., Cheung C.L., Bow C.H.Y., Lau K.S., Sham P.C., Tan K.C.B. and Kung A.W.C., Association of Cdx1 Binding Site of Periostin Gene with Bone Mineral Density and Vertebral Fracture Risk, The 3rd Joint Meeting of the European Calcified Tissue Society and the International Bone and Mineral Society, 7-11 MAY, Athens, Greece. Athens, Greece, 2011, 7-11 MAY.

Researcher : Lau KS

List of Research Outputs

Lam J.K., Lam C.W., Kung A.W.C., Tan K.C.B., Lau K.S. and Lam K.S.L., A man with hypophosphataemia, BMJ. 2011, 342:d773.

Researcher : Lau KW

List of Research Outputs

Lau K.W., Chan K.H., Yeung S.C., Ip M.S.M. and Mak J.C.W., Effects of cigarette smoke exposure on serum 5-HT levels in rats, American Journal of Respiratory and Critical Care Medicine. 2011, 183: A2454.

Researcher : Lau WCS

Project Title:	Prospective study of the clinical pattern of systemic lupus erythematosus in Hong Kong
Investigator(s):	Lau WCS
Department:	Medicine
Source(s) of Funding:	Other Funding Scheme
Start Date:	01/1993

Project Title:	Effects of sex hormones on lymphocyte function in systemic lupus erythematosus
Investigator(s):	Lau WCS, Mok TMY
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Project Title:	A study to evaluate the immunopathology of Severe Acute Respiratory Syndrome
Investigator(s):	Lau WCS, Chan EYT, Cheung BMY
Department:	Medicine
Source(s) of Funding:	VCO SARS Research Fund
Start Date:	07/2003

Project Title:	Evaluation of the effects of sex hormones on neutrophils and macrophage apoptosis and macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus
Investigator(s):	Lau WCS
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	Dendritic cell function and their effects on B cell activation in systemic lupus erythematosus
Investigator(s):	Lau WCS
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	12/2005

Project Title:	Evaluation of the effects of micro-RNA146a on the function of bone marrow dendritic cells in systemic lupus erythematosus
Investigator(s):	Lau WCS
Department:	Medicine
Source(s) of Funding:	Travel Grants for NSFC/RGC JRS
Start Date:	12/2009

Project Title:	Characterisation of the features and functional changes of bone marrow dendritic cells in systemic lupus erythematosus
Investigator(s):	Lau WCS
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	10/2010

List of Research Outputs

Jin O., Kavikondala S., Sun L.Y., Gu J.R., Fu R., Mok T.M.Y., Chan W.K., Yeung J.S.L., Nie Y. and Lau W.C.S., Abnormalities in circulating plasmacytoid dendritic cells in patients with systemic lupus erythematosus., Arthritis Research & Therapy. 2010, 12(4): R137.

Lau W.C.S., Are patients with systemic lupus erythematosus and other connective tissue diseases at increased risk of cardiovascular events? , First International Rheumatology and Cardiology Focus on INFLAMMATION: A SHARED CONCERN, Prato, Italy.. 2011.

Lau W.C.S., Current issues in the management of ankylosing spondylitis and rheumatoid arthritis in Asia. , Asia Rheumatology Expert Advisory Council for Health (Asia REACH), Hong Kong. . 2011.

Lau W.C.S., Current issues on the management of ankylosing spondylitis and rheumatoid arthritis in Asia. , Asia Rheumatology Expert Advisory Council for Health (Asia REACH), Phuket, Thailand.. 2011.

Lau W.C.S., Dendritic cells and autoimmunity. , 11th International Workshop on Autoantibodies and Autoimmunity (IWAA), Shanghai, China. . 2011.

Lau W.C.S., Excellence in Medicine and Rheumatology in Hong Kong: Enter the Dragon., 14th Congress of Asia Pacific League of Associations for Rheumatology (APLAR), Hong Kong. 2010.

Lau W.C.S., Fitness-to-Practice: Where are we today?, 6th Congress of the Aisan Medical Education Association (AMEA), Kuala Lumpur, Malaysia. 2011.

Lau W.C.S., How to submit your paper, from the editor’s view. , Envision Publication Workshop, Shanghai, China.. 2011.

Lau W.C.S., IL-6 in Autoimmune Disease – A New Paradigm. , Ten Topics in Rheumatology Asia, Singapore. 2010.

Lau W.C.S., Novel therapeutic targets in autoimmune rheumatic diseases., Hong Kong College of Physicians Annual Scientific Meeting, Hong Kong.. 2010.

Lau W.C.S., Problem Based Learning: Experience from the University of Hong Kong., East-West Alliance Conference, Shantou, China. 2011.

Lau W.C.S., Rheumatic disease., Health Talk, Hong Kong. . 2011.

Lau W.C.S., Rheumatoid Arthritis (RA)., 1st Symposium of the Asia Pacific League of Associations for Rheumatology (APLAR), Taipei, Taiwan.. 2011.

Lau W.C.S., Rheumatological or immunological diseases., “Explore the World of Medicine” Public Lecture Series, Hong Kong. . 2011.

Lau W.C.S., Screening and diagnosis of common rheumatological disease – for young and late onset., Health Talk, Hong Kong.. 2011.

Lau W.C.S., The Asian perspective on geographical/ethnic variation., Fostamatinib in SLE Scientific Advisory Board Meeting, London, United Kingdom.. 2011.

Lau W.C.S., The International Journal of Rheumatic Diseases – a journal in evolution., International Journal of Rheumatology Disease . 2010, 13(3): 187-188.

Lau W.C.S., The role of bone marrow and peripheral dendritic cells in SLE., 14th Congress of Asia Pacific League of Associations for Rheumatology (APLAR), Hong Kong. . 2010.

Lau W.C.S., Use of biological therapies in the Asian Pacific region., 14th Congress of Asia Pacific League of Associations for Rheumatology (APLAR), Hong Kong.. 2010.

Lim K. and Lau W.C.S., Perception is everything: OA is exciting., International Journal of Rheumatic Diseases. 2011, 14(2): 111-112.

Mok T.M.Y., Yiu K.H., Wong C.Y., Qiuwaxi J., Lai W.H.K., Wong R.W.S., Tse H.F. and Lau W.C.S., Low circulating level of CD133+KDR+cells in patients with systemic sclerosis., Clinical and Experimental Rheumatology. 2010, 28(5 Suppl 62): S19-25.

Mok T.M.Y., Wu H., Lo Y. and Lau W.C.S., Serum IL-17 and IL-23 to Th1/Th2 cytokines and disease activity in systemic lupus erythematosus., The Journal of Rheumatology. 2010, 37(10): 2046-2052.

Mok T.M.Y., Lau W.C.S., Chiu S.S.H., Tso A.W.K., Lo Y. and Law S.C., Systemic sclerosis is an independent risk factor for increased coronary artery calcium deposition, Arthritis Rheum. 2011, 63(5): 1387-95.

Mok T.M.Y. and Lau W.C.S., The burden and measurement of cardiovascular disease in systemic sclerosis. , Nature Reviews Rheumatology. 2010, 6(7): 430-434.

Mok T.M.Y., Wu H., Lo Y. and Lau W.C.S., The relation of interleukin 17 (IL-17) and IL-23 to Th1/Th2 cytokines and disease activity in systemic lupus erythematosus., The Journal of Rheumatology. 2010, 37(10): 2046-2052.

Vista E.S. and Lau W.C.S., What about supplements for osteoarthritis? A critical and evidenced-based review. , International Journal of Rheumatic Diseases. 2011, 14(2): 152-158.

Woo G.K., Wong A.H., Lee W.Y., Lau W.C.S., Cheng P.K., Leung P.C. and Lim W.W., Comparison of laboratory diagnostic methods for measles infection and identification of measles virus genotypes in Hong Kong., Journal of Medical Virology. 2010, 82(10): 1773 – 1781.

Yang J., Yang W., Hirankarn N., Ye D.Q., Zhang Y., Pan H.F., Mok C.C., Chan T.M., Wong R.W.S., Mok M.Y., Lee K.W., Wong S.N., Leung A.M.H., Li X.P., Avihingsanon Y., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Shotelersuk V., Baum L., Kwan P., Lee T.L., Ho M.H.K., Lee P.P.W., Wong W.H.S., Zeng S., Zhang J., Wong C.M., Ng I.O.L., Garcia-Barcelo M.M., Cherny S.S., Tam P.K.H., Sham P.C., Lau W.C.S. and Lau Y.L., ELF1 is associated with systemic lupus erythematosus in Asian populations, Human Molecular Genetics. 2011, 20(3): 601-607.

Zhang Y., Yang W., Mok C.C., Chan T.M., Wong R.W.S., Mok T.M.Y., Lee K.W., Wong S.N., Leung A.M.H., Lee T.L., Ho M.H.K., Lee P.P.W., Wong W.H.S., Yang J., Zhang J., Wong C.M., Ng I.O.L., Garcia-Barcelo M.M., Cherny S.S., Tam P.K.H., Sham P.C., Lau W.C.S. and Lau Y.L., Two missense variants in UHRF1BP1 are indpendently associated with systemic lupus erythematosus in Hong Kong Chinese, Genes and Immunity. 2011, 12(3): 231-234.

Zhu J., Mak H.K.F., Mok T.M.Y., Chan Q. and Lau W.C.S., Role of functional neuroimaging in Neuropsychiatric (NP) Systemic Lupus Etythematosus (SLE) – a combined study of Diffusion Tensor Imaging (DTI) and MR Spectroscopy (MRS) at 3 Tesla Magnetic Resonance Imaging, 49th Annual Meeing ASNR, Seattle, June 4 to 10 (oral).. 2011.

Researcher : Law SC

List of Research Outputs

Chen C., Tso A.W.K., Law S.C., Cheung B.M.Y., Ong K.L., Wat N.M.S., Janus E.D., Xu A. and Lam K.S.L., Plasma Level of Pigment Epithelium-Derived Factor Is Independently Associated with the Development of the Metabolic Syndrome in Chinese Men: A 10-Year Prospective Study. , J Clin Endocrinol Metab.. 2010, 95: 5074-81.

Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Ong K.L., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., Genetic variants associated with persistent central obesity and the metabolic syndrome in a 12-year longitudinal study, Euro J Endocrinol . 2011, 164: 381-8.

Michele Y.U.E.N., Wing Sun C.H.O.W., Chen C., Ting Chung P.U.N., Law S.C., Tso A.W.K., Xu A. and Lam K.S.L., . Circulating Plasma Pigment Epithelium-Derived Factor (PEDF) Levels Are Associated with Insulin Resistance in Women with Estrogen Deficiency, 71th American Diabetes Association Scientific Sessions, San Diego, CA. 2011.

Mok T.M.Y., Lau W.C.S., Chiu S.S.H., Tso A.W.K., Lo Y. and Law S.C., Systemic sclerosis is an independent risk factor for increased coronary artery calcium deposition, Arthritis Rheum. 2011, 63(5): 1387-95.

Tso A.W.K., Lam T.K.Y., Xu A., Yiu K.H., Tse H.F., Li L.S.W., Law S.C., Cheung B.M.Y., Cheung R.T.F. and Lam K.S.L., Serum adipocyte fatty acid-binding protein is associated with ischemic stroke and early death, Neurology. 2011, 76(23): 1968-75.

Researcher : Lee KLF

List of Research Outputs

Siu D.C.W., Yiu K.H., Lee K.L.F., Yan G., Lee S.W.L., Lau C.P. and Tse H.F., Effects of Right Low Atrial Septal versus Right Atrial Appendage Pacing on Atrial Mechanical Function and Dyssynchrony in Patients with Sinus Node Dysfunction and Paroxysmal Atrial Fibrillation, European Journal of Echocardiography. 2010, 11: 672.

Siu D.C.W., Yan G., Yue W., Lee K.L.F., Lee S.W.L., Lau C.P. and Tse H.F., Effects of right low atrial septal versus right atrial appendage pacing on atrial mechanical function and dyssynchrony in patients with sinus node dysfunction and paroxysmal atrial fibrillation , Heart Rhythm. 2011.

Siu D.C.W., Yiu K.H., Yan G., Yue W., Lee K.L.F., Lee S.W.L., Lau C.P. and Tse H.F., Effects of right low atrial septal versus right atrial appendage pacing on atrial mechanical function and dyssynchrony in patients with sinus node dysfunction and paroxysmal atrial fibrillation, European Society of Echocardiogram. 2010.

Siu D.C.W., Lee K.L.F., Yue W., Yan G., Lee S.W.L., Lau C.P. and Tse H.F., Effects of right low atrial septal versus right atrial appendage pacing on strial mechanical function and dyssynchrony in patients with sinus node dysfunction and paroxysmal atrial fibrillation. , Heart Rhythm. 2011.

Wang M.M., Siu D.C.W., Yan G., Yue W., Lee K.L.F., Lee S.W.L., Lau C.P. and Tse H.F., Effects of right low atrial septal versus right atrial appendage pacing on atrial mechanical function and dyssynchrony in patients with sinus node dysfunction and paroxysmal atrial fibrillation , Heart Rhythm. 2011.

Researcher : Lee SWL

List of Research Outputs

Siu D.C.W., Yiu K.H., Lee K.L.F., Yan G., Lee S.W.L., Lau C.P. and Tse H.F., Effects of Right Low Atrial Septal versus Right Atrial Appendage Pacing on Atrial Mechanical Function and Dyssynchrony in Patients with Sinus Node Dysfunction and Paroxysmal Atrial Fibrillation, European Journal of Echocardiography. 2010, 11: 672.

Siu D.C.W., Yan G., Yue W., Lee K.L.F., Lee S.W.L., Lau C.P. and Tse H.F., Effects of right low atrial septal versus right atrial appendage pacing on atrial mechanical function and dyssynchrony in patients with sinus node dysfunction and paroxysmal atrial fibrillation , Heart Rhythm. 2011.

Siu D.C.W., Yiu K.H., Yan G., Yue W., Lee K.L.F., Lee S.W.L., Lau C.P. and Tse H.F., Effects of right low atrial septal versus right atrial appendage pacing on atrial mechanical function and dyssynchrony in patients with sinus node dysfunction and paroxysmal atrial fibrillation, European Society of Echocardiogram. 2010.

Siu D.C.W., Lee K.L.F., Yue W., Yan G., Lee S.W.L., Lau C.P. and Tse H.F., Effects of right low atrial septal versus right atrial appendage pacing on strial mechanical function and dyssynchrony in patients with sinus node dysfunction and paroxysmal atrial fibrillation. , Heart Rhythm. 2011.

Wang M.M., Siu D.C.W., Yan G., Yue W., Lee K.L.F., Lee S.W.L., Lau C.P. and Tse H.F., Effects of right low atrial septal versus right atrial appendage pacing on atrial mechanical function and dyssynchrony in patients with sinus node dysfunction and paroxysmal atrial fibrillation , Heart Rhythm. 2011.

Wang M.M., Yan G., Yue W., Siu D.C.W., Yiu K.H., Lee S.W.L. and Tse H.F., Left ventricular mechanical dyssynchrony predicts exercise capacity in patients with coronary artery disease and narrow QRS duration, Journal of The American Society of Echocardiography. 2011.

Yan G., Wang M.M., Yue W., Luk T.H., Dai Y.L.E., Siu D.C.W., Yiu K.H., Lee S.W.L. and Tse H.F., Coenzyme Q10 Supplementation Improves Left Ventricular Torsion In Patients With Ischemic Cardiomyopathy, AHA. 2010.

Yiu Y.F., Chan Y.H., Yiu K.H., Siu D.C.W., Li L.S.W., Wong L.Y., Lee S.W.L., Tam S., Wong E.W.K., Cheung B.M.Y. and Tse H.F., Vitamin D deficiency is associated with depletion of circulating endothelial progenitor cells and endothelial dysfunction in patients with type 2 diabetes. , J Clin Endocrinol Metab. 2011, 96(5): E830-835.

Yue W., Wang M.M., Yan G., Yiu K.H., Yin L.X., Lee S.W.L., Siu D.C.W. and Tse H.F., Smoking is associated with depletion of circulating endothelial progenitor cells and elevated pulmonary artery pressure in patients with coronary artery disease , American Journal of Cardiology . 2010, 2010 Nov 1;106(9):1248-54.

Researcher : Lee TMC

Project Title:	Selective attention biases of people with major depressive disorder, and its relationship with brain damages.
Investigator(s):	Lee TMC, Leung KK
Department:	Psychology
Source(s) of Funding:	Small Project Funding
Start Date:	09/2005

Project Title:	A post-discharge service for brain injury patients in Central and Western District
Investigator(s):	Lee TMC, Chan SSC, Hung KN, Li LSW, Leung KK
Department:	Psychology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	12/2006

Project Title:	Cognitive Dysfunction after Anesthesia (CoDA) Study
Investigator(s):	Lee TMC
Department:	Psychology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2007

Project Title:	Research Output Prize (Faculty of Social Sciences)
Investigator(s):	Lee TMC
Department:	Psychology
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	11/2007

Project Title:	Effects of moods on risk-taking behavior: cognitive and neural mechanisms
Investigator(s):	Lee TMC
Department:	Psychology
Source(s) of Funding:	Travel Grants for NSFC/RGC JRS
Start Date:	12/2007

Project Title:	Effects of mood on risk-taking behavior: cognitive and neural mechanisms
Investigator(s):	Lee TMC
Department:	Psychology
Source(s) of Funding:	Matching Fund for NSFC Academic Collaboration Award
Start Date:	01/2009
Completion Date:	12/2010

Project Title:	Effects of olfactory training on inhibition presented by people suffering from strokes
Investigator(s):	Lee TMC
Department:	Psychology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2010
Completion Date:	01/2011

Project Title:	The Brain Mechanisms to Use Electronic "Bat Ears" to Replace Vision: From Human to Animal Users
Investigator(s):	Lee TMC
Department:	Psychology
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2010

Project Title:	Memory and attention training to reduce the risk of developing dementia
Investigator(s):	Lee TMC, Chu LW, Hou WK
Department:	Psychology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	09/2010

Project Title:	Modality-specific neural effects of meditation
Investigator(s):	Lee TMC
Department:	Psychology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2011

List of Research Outputs

Gao J., Cheung R.T.F., Lee T.M.C., Chu L.W. and Chan Y.S., The effect of normal and abnormal ageing on prospective memory showed increased cognitive conflict: a functional MRI study, Hong Kong Medical Journal, 17: 27. [16^th Medical Research Conference. H.K. Jan. 22, 2011]. 2011.

Researcher : Lee YK

List of Research Outputs

Lee Y.K., Ng K.M., Lai K.W.H., Chan Y.C., Lau Y.M., Lian Q., Tse H.F. and Siu D.C.W., Calcium Homeostasis in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes., Stem Cell Reviews and Reports. 2011.

Liao S., Liu Y., Siu D.C.W., Zhang Y., Lai K.W.H., Au K.W., Lee Y.K., Li R.A. and Tse H.F., Proarrhythmic risk of embryonic stem cell-derived cardiomyocyte transplantation in infarcted myocardium, Heart Rhythm. 2010, 7(12): 1852-9.

Ng K.M., Chan Y.C., Lee Y.K., Lai W.H., Au K.W., Fung M.L., Siu D.C.W., Li R.A. and Tse H.F., Cobalt Chloride Pretreatment Promotes Cardiac Differentiation of Human Embryonic Stem Cells under atmospheric oxygen level. x, Cell Reprogramming. In press.. 2011.

Ng K.M., Chan Y.C., Lee Y.K., Lai W.H., Fung M.L., Siu D.C.W., Li R.A. and Tse H.F., Cobalt chloride pre-treatment enhances the calcium handling of human embryonic stem cells-derived cardiomyocytes, Differentiation, 80:S44 Suppl. 1, 2010.

Ng K.M., Lee Y.K., Lai K.W.H., Chan Y.C., Fung M.L., Tse H.F. and Siu D.C.W., Exogenous Expression of Human apoA-I Enhances Cardiac Differentiation of Pluripotent Stem Cells., PLoS One. 2011.

Researcher : Lee YK

List of Research Outputs

Ng K.M., Lee Y.K., Lai K.W.H., Chan Y.C., Fung M.L., Tse H.F. and Siu D.C.W., Exogenous Expression of Human apoA-I Enhances Cardiac Differentiation of Pluripotent Stem Cells., PLoS One. 2011.

Researcher : Leung AYH

Project Title:	Provision of free alemtuzumab (anti-CD52) to patients with chronic lymphocytic leukemia refractory to conventional chemotherapy
Investigator(s):	Leung AYH, Kwong YL
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	11/2007

Project Title:	Provision of free service for serum polyoma BK virus quantification to kidney transplant recipients in Hong Kong
Investigator(s):	Leung AYH, Kwong YL, Tang SCW
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2009

Project Title:	Is Jak2V617F mutation a stem cell event in chronic myeloproliferative disease ?
Investigator(s):	Leung AYH, Liang RHS
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2009

Project Title:	Detection of WU and KI polyomaviruses from patients with acute respiratory tract infections in Hong Kong
Investigator(s):	Leung AYH, Kwong YL
Department:	Medicine
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2009

Project Title:	Provision of free molecular tests for patients with acute myeloid leukemia with normal cytogenetics
Investigator(s):	Leung AYH
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2010

Project Title:	Is aldehyde dehydrogenase a negative regulator of primitive hematopoiesis during embryonic development?
Investigator(s):	Leung AYH
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010

Project Title:	Study of Microglia and Acute Myeloid Leukemia in Zebrafish
Investigator(s):	Leung AYH
Department:	Medicine
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	05/2010

Project Title:	A novel role of methionine aminopeptidase 2 (MetAP-2) in the regulation of hematopoietic stem cell during definitive hematopoiesis
Investigator(s):	Leung AYH
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2010

Project Title:	Provision of free sorafenib for patients with refractory or relapsed acute myeloid leukemia to bridge them to curative bone marrow transplantation
Investigator(s):	Leung AYH, Kwong YL
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	07/2010

List of Research Outputs

Chan K.S., Au W.Y., Wong C.Y., Liang R.H.S., Leung A.Y.H., Kwong Y.L. and Khong P.L., Metabolic activity measured by F-18 FDG PET in NK-cell lymphoma compared to aggressive B- and T-cell lymphomas, Clinical Nuclear Medicine . 2010, 35: 571-575.

Chan T.S., Au W.Y., Lam K., Lam Y.F., So J.C.C., Leung A.Y.H., Tse E.W.C., Lie A.K.W. and Kwong Y.L., Donor cell leukaemia after allogeneic haematopoietic SCT followed by prolonged thalidomide maintenance for multiple myeloma, Bone Marrow Transplant. 2011, [Epub ahead of print].

Fung T.K., Chung I.S., Liang R.H.S. and Leung A.Y.H., Role of a novel zebrafish nup98 during embryonic development, Experimental Hematology. 2010, Epub.

Gill H., Chim J.C.S., Au W.Y., Loong F., Tse E.W.C., Leung A.Y.H. and Kwong Y.L., Non-gastric marginal zone B cell lymphoma: clinicopathologic features and treatment results, Ann Hematol. 2011, [Epub ahead of print].

Gill H.S., Lau W.H., Chan A.C., Leung R.Y.Y., Khong P.L., Leung A.Y.H. and Kwong Y.L., CD20 expression in natural killer T cell lymphoma, Histopathology . 2010, 57: 157-159.

Gu J., Chan T., Zhang J., Leung A.Y.H., Kwong Y.L. and Khong P.L., Whole-body diffusion weighted imaging (DWI): the added value to whole-body MRI at initial diagnosis of lymphoma, American Journal of Roentgenology (in press). 2011.

Lam B., Wong M.K.Y., Lu K.H., Au W.Y., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Liang R.H.S., Lam W.K., Ip M.S.M. and Lie A.K.W., Effects of Azithromycin in bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation – a randomized double-blinded placebo-controlled study, Bone Marrow Transplantation. 2011, Epub ahead of print.

Lam C.L.D., Lam B., Wong M.K.Y., Lu K.H., Au W.Y., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Liang R.H.S., Lam W.K., Ip M.S.M. and Lie A.K.W., Effects of Azithromycin in bronchiolitis obliterans syndrome after hematopoietic SCT-a randomized double-blinded placebo-controlled study, Bone marrow transplantation. 2011, Epub ahead of print.

Ma C.H., Chung I.S., Liang R.H.S. and Leung A.Y.H., A DEAB-sensitive aldehyde dehydrogenase regulates hematopoietic stem and progenitor cells development during primitive hematopoiesis in zebrafish embryos, Leukemia. Nature Publishing Group, 2010, 24: 2090-2099.

Ma C.H., Chung I.S., Lin H., Yang D. and Leung A.Y.H., Methionine aminopeptidase II in zebrafish definitive hematopoiesis, Hong Kong Society of Developmental Biology. 2011.

Wong M.K.Y., Loong F., Khong P.L., Kwong Y.L. and Leung A.Y.H., Mediastinal cryptococcosis masquerading as therapy-refractory lymphoma, Annals of Hematology. 2010, Epub.

Researcher : Leung JCK

Project Title:	Infiltrating leukocytes in the tubulointerstitium of IgA nephropathy: Their role in pathogenesis
Investigator(s):	Leung JCK, Lai KN
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2009

Project Title:	The role of aldosterone in the pathogenesis of IgA nephropathy
Investigator(s):	Leung JCK, Lai KN
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2009
Completion Date:	06/2011

Project Title:	Renin-angiotensin system within the podocytes in IgA nephropathy
Investigator(s):	Leung JCK, Lai KN
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2011

List of Research Outputs

Au W.S., Chan G., Leung J.C.K., Chan L.Y., Lan H.Y., Lai K.N. and Tang S.C.W., Ac-SDKP reduces proinflammatory response in PTEC during pathogenic albumin load, J Am Soc Nephrol. 2010, 21: 279A.

Huang W., Gu H., Li R., Lou T., Zhang J., Shi W., Ye Z., Zhou Y., Li C., Xiong S., Li L., Wu C., Leung J.C.K., Lam M.F., Lai K.N. and Wang A.Y.M., Association of -27T>C and its haplotype at the putative promoter for IgA-specific receptor gene with IgA nephropathy among the Chinese Han population, Nephrology Dialysis Transplantation. 2011, 26(8): 2537-44.

Lai K.N., Chan L.Y., Guo H., Tang S.C.W. and Leung J.C.K., Additive effect of PPAR-γ agonist and ARB in treatment of experimental IgA nephropathy, Pediatric Nephrology. 2011, 26(2): 257-266.

Lai K.N., Lam M.F., Leung J.C.K., Chan L.Y. and Tang S.C.W., Clinical and biochemical profile of a low-glucose degradation product peritoneal dialysis fluid: a four-year study, J Am Soc Nephrol. 2010, 21: 307A.

Lai K.N., Leung J.C.K. and Tang S.C.W., The Renin-Angiotensin System, In: Diabetes and the Kidney, Edited by K.N. Lai and S.C. Tang, S Karger AG, Basel, Switzerland. 2011, 135-144.

Lai K.N., Leung J.C.K. and Tang S.C.W., The renin-angiotensin system, Contributions to Nephrology. 2011, 170: 135-44.

Leung J.C.K., Chan L.Y., Tang S.C.W. and Lai K.N., Glomerulotubular interaction in IgA nephropathy induces oxidative damages in tubular epithelial cells: role of crosstalk between angiotensin II and aldosterone. Proceedings of the World Congress of Nephrology April 2011, J Am Soc Nephrol. 2010.

Tang S.C.W., Chan Y.Y., Leung J.C.K., Cheng A.S., Lan H.Y. and Lai K.N., Additive Renoprotective Effects Of B2-kinin Receptor Blocker And PPAR-y Agonist In Uninephrectomized Db/db Mice [journal Impact Factor 4.602] (in Press), Lab Invest . 2011, 91(9): 1351-62.

Tang S.C.W., Chan L.Y., Leung J.C.K., Lan H.Y. and Lai K.N., Additive renoprotective effects of B2-kinin receptor blocker and PPAR-γ agonist in uninephrectomized db/db mice, J Am Soc Nephrol. 2010, 21: 692A.

Tang S.C.W., Leung J.C.K. and Lai K.N., Diabetic Tubulopathy: an Emerging Entity, In: Diabetes and the Kidney, Edited by K.N. Lai and S.C. Tang, S Karger AG, Basel, Switzerland. 2011, 124-134.

Tang S.C.W., Leung J.C.K. and Lai K.N., Diabetic tubulopathy: an emerging entity, Contributions to Nephrolology. 2011, 170: 124-134.

Tang S.C.W., Chan Y.Y., Leung J.C.K., Cheng A.S., Lin M., Lan H.Y. and Lai K.N., Differential effects of advanced glycation end-products on renal tubular cell inflammation, Nephrology (Carlton, Vic). 2011, 16(4): 417-25.

Tang S.C.W., Leung J.C.K., Chan L.Y., Lan H.Y. and Lai K.N., Renoprotection by rosiglitazone in accelerated type 2 diabetic nephropathy: role of STAT1 inhibition and nephrin restoration, American Journal of Nephrology. 2010, 32: 145-155.

Tang S.C.W., Leung J.C.K. and Lai K.N., The Kallikrein-Kinin System, In: Diabetes and the Kidney, Edited by K.N. Lai and S.C. Tang, S Karger AG, Basel, Switzerland. 2011, 145-155.

Tang S.C.W., Leung V.T.M., Chan Y.Y., Wong S.S., Chu D.W., Leung J.C.K., Ho Y.W., Lai K.N., Ma L., Elbein S.C., Bowden D.W., Hicks P.J., Comeau M.E., Langefeld C.D. and Freedman B.I., The acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with nephropathy in Chinese patients with type 2 diabetes, Nephrology Dialysis Transplantation. 2010, 25(12): 3931-4.

Tang S.C.W., Leung J.C.K. and Lai K.N., The kallikrein-kinin system, Contributions to Nephrology. 2011, 170: 145-155.

Researcher : Leung RCY

List of Research Outputs

Wong H., Leung R.C.Y., Lau S., Chiu J., Cheung P., Wong T., Liang R., Epstein R. and Yau T.C.C., Presence of an in-situ component predicts reduced tumor aggressiveness in luminal subtype of invasive breast cancer (Abstract), Primary Therapy of Early Breast Cancer - 11th International Conference. St.Gallen, Switzerland, 16-19 March 2011. The Breast. 2011, 20(Suppl 1): S39.

Yau T.C.C., Leung R.C.Y., Wong H., Chiu J., Chan P., Pang R.W.C., Fan S.T. and Poon R.T.P., Efficacy and safety of single-agent sunitinib in treating patients with advanced hepatocellular carcinoma after sorafenib failure: a prospective, open-label, phase II study (Abstract), ESMO 13th World Congress on Gastrointestinal Cancer, Barcelona, Spain, 22-25 June 2011. Annals of Oncology. 2011, 22(Suppl 5).

Researcher : Leung VTM

List of Research Outputs

Tang S.C.W., Leung V.T.M., Chan Y.Y., Wong S.S., Chu D.W., Leung J.C.K., Ho Y.W., Lai K.N., Ma L., Elbein S.C., Bowden D.W., Hicks P.J., Comeau M.E., Langefeld C.D. and Freedman B.I., The acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with nephropathy in Chinese patients with type 2 diabetes, Nephrology Dialysis Transplantation. 2010, 25(12): 3931-4.

Researcher : Leung WK

List of Research Outputs

Shin V.Y., Jin H.C., Ng E.K.O., Cho C.H., Leung W.K., Sung J.J.Y. and Chu K.M., 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone promoted gastric cancer growth through prostaglandin E receptor (EP2 and EP4) in vivo and in vitro, Cancer Sci. 2011, 102: 926-33.

Shin V.Y., Ng E.K.O., Cheng A.S.L., Chong W.W.S., Wong C.Y.P., Leung W.K., Sung J.J.Y. and Chu K.M., NF-κB targets miR-16 and miR-21 in gastric cancer: involvement of prostaglandin E receptors, Carcinogenesis. 2011, 32: 240-5.

Researcher : Leung YH

List of Research Outputs

Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Association of a genetic variant in adrenomedullin gene with its plasma level , Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Thomas G.N., Lam T.H. and Lam K.S.L., Mendelian randomisation analysis suggests that plasma interleukin-6 is raised in hypertension but does not cause its development, Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Plasma adrenomedullin level is related to plasma interleukin-6 and a polymorphism in the adrenomedullin gene, Basic & Clinical Pharmacology & Toxicology. Presented at the 10th Congress of the European Association for Clinical Pharmacology and Therapeutics, Budapest. 2011, 109 (Suppl. 1): 102-103.

Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Lam T.H., Cheung B.M.Y. and Lam K.S.L., A genetic variant in the gene encoding adrenomedullin predicts the development of dysglycemia over 6.4 years in Chinese, Clin Chim Acta. 2010, 412: 353-7.

Ong K.L., Cheung B.M.Y., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Association of a genetic variant in adrenomedullin gene with its plasma level., Oral Presentation at the Annual Scientific Meeting of the Hong Kong Society of Endocrinology, Metabolism and Reproduction, Hong Kong. 2010.

Samaranayake N.R., Ong K.L., Leung Y.H. and Cheung B.M.Y., Pharmacological management of obesity in the national health and nutrition examination survey (NHANES) 2007-2008), Basic & Clinical Pharmacology & Toxicology. Presented at the 10th Congress of the European Association for Clinical Pharmacology and Therapeutics, Budapest. 2011, 109 (Suppl. 1): 138-139.

Researcher : Li CS

List of Research Outputs

Cheung C.Y., Lam M.F., Lee K.C., Chan G.S.W., Chan K.W., Chau K.F., Li C.S., Chan D.T.M. and Lai K.N., Renal cell carcinoma of native kidney in Chinese renal transplant recipients: a report of 12 cases and a review of the literature, International Urology and Nephrology. 2011, 43(3): 675-80.

Researcher : Li FYL

Project Title:	Frontiers in CardioVascular Biology 2010 Toll-like receptor 4 inactivation alleviates impaired vascular reendothelialisation by improving endothelial progenitor cell adhesion
Investigator(s):	Li FYL
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	07/2010
Completion Date:	07/2010

List of Research Outputs

Li F.Y.L., Cheng K.Y., Lam K.S.L., Vanhoutte P.M.G.R. and Xu A., Cross-talk Between Adipose Tissue And Vasculature: Role Of Adiponectin, Acta Physiologica. 2010.

Li F.Y.L., Wang Y., Xiao Y., Lam K.S.L. and Xu A., Endothelial-specific Activation Of Amp-activated Protein Kinase Improves Impairment In Endothelial Repair In Type 1 Diabetic Mice, Sixth International Symposium on Healthy Aging: “A New Golden Age”. 2011.

Li F.Y.L., Wang Y., Lam K.S.L. and Xu A., Endothelium-specific activation of AMP-activated protein kinase alleviates diabetes-induced impairment in endothelial repair in mice, 16th Medical Research Conference. 2011.

Li F.Y.L., Hoo R.L.C., Lam K.S.L. and Xu A., Outstanding Scientific Work – Winning poster presentation , Frontiers in Cardiovascular Biology; European Society of Cardiology. 2010.

Li F.Y.L., Hoo R.L.C., Lam K.S.L. and Xu A., Toll-like receptor 4 inactivation alleviates impaired vascular reendothelialisation by improving endothelial progenitor cell adhesion, In: Hans Michael Piper, Journal of Cardiovascular Research. United Kingdom, Oxford Journals, 2010, 87: S48.

Ye D., Li F.Y.L., Lam K.S.L., Wang Y. and Xu A., Genetic Inactivation of Toll-Like Receptor 4 Alleviates Diet-induced Nonalcoholic Steatohepatitis by Inhibiting Reactive Oxygen Species-evoked Activation of X-box Binding Protein-1 in ApoE-deficient Mice, ADA 2011.

Researcher : Li G

Project Title:	Volume-sensitive chloride current and cell volume regulation in human atrial myocytes
Investigator(s):	Li GR, Lau CP, Chiu SW, Tse HF
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2001

Project Title:	Calcium Signals and Cell Proliferation in Human Cardiac Fibroblasts
Investigator(s):	Li GR, Lau CP, Lee HC, Tse HF
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2009

Project Title:	Study on the Natural Anti-Atrial Fibrillation Compound Acacetin and Its Analogues/Derivatives
Investigator(s):	Li GR, Vanhoutte PMGR
Department:	Medicine
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	03/2010

Project Title:	Human Atrial IKur/hKv1.5 and Protein Tyrosine Kinase Regulation
Investigator(s):	Li GR
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	10/2010
Completion Date:	09/2011

Project Title:	ISSCR 9th Annual Meeting BOTH ION CHANNELS AND CALCIUM SIGNALS REGULATE PROLIFERATION IN HUMAN ADULT MESENCHYMAL STEM CELLS FROM BONE MARROW
Investigator(s):	Li GR
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	06/2011
Completion Date:	06/2011

List of Research Outputs

Che H. and Li G., Characterization of transient receptor potential channels in human preadipocytes, Omics Meets Cell Biology, May 2011. Alpbach Congress Centrum. Alpbach, Austria. 2011, 68-108.

Li G., Chairpersons, International Symposium on Basic Cardiology, the 13th South China International Congress of Cardiology, Guangzhou, China. 2011.

Li G., Therapeutic Targets for DrugDevelopment of Anti-atrial Fibrillation, the 13th South China International Congress of Cardiology, Guangzhou, China. 2011.

Lu L., Li G. and Ballard H.J., The Identification of Chloride Channels on Skeletal Myoblasts, Omics Meets Cell Biology, May 2011. Alpbach Congress Centrum. Alpbach, Austria. 2011, 213.

Wu H., Wu W. and Li G., Rate-dependent block of hKv1.5 channels and the molecular determinants by the natural flavone acacetin, International Academy of Cardiology 15th World Congress on Heart Disease Annual Scientific Sessions, Vancouver, BC, Canada; July 24-27, 2010.. 2010.

Zhang Y., Tao R. and Li G., Both ion channels and calcium signals regulate proliferation in human adult mesenchymal stem cells from bone marrow, ISSCR 9th Annual Meeting. June 2011. Metro Toronto Convention Centre, TORONTO, Canada. 2011, 156.

Zhang Y., Lau C.P. and Li G., Human cardiac Kv4.3 channels are regulated by EGFR kinase and Src-family kinases., International Academy of Cardiology 15th World Congress on Heart Disease Annual Scientific Sessions, Vancouver, BC, Canada; July 24-27, 2010.. 2010.

Researcher : Li GR

Project Title:	Volume-sensitive chloride current and cell volume regulation in human atrial myocytes
Investigator(s):	Li GR, Lau CP, Chiu SW, Tse HF
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2001

Project Title:	Calcium Signals and Cell Proliferation in Human Cardiac Fibroblasts
Investigator(s):	Li GR, Lau CP, Lee HC, Tse HF
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2009

Project Title:	Study on the Natural Anti-Atrial Fibrillation Compound Acacetin and Its Analogues/Derivatives
Investigator(s):	Li GR, Vanhoutte PMGR
Department:	Medicine
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	03/2010

Project Title:	Human Atrial IKur/hKv1.5 and Protein Tyrosine Kinase Regulation
Investigator(s):	Li GR
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	10/2010
Completion Date:	09/2011

Project Title:	ISSCR 9th Annual Meeting BOTH ION CHANNELS AND CALCIUM SIGNALS REGULATE PROLIFERATION IN HUMAN ADULT MESENCHYMAL STEM CELLS FROM BONE MARROW
Investigator(s):	Li GR
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	06/2011
Completion Date:	06/2011

List of Research Outputs

Che H. and Li G.R., Functional expression of transient receptor potential channels in human preadipocytes, 16th Medical Research Conference, Department of Medicine, HKU. 2011, 17(1): 32.

Li G.R., Chairmans, Oral Ab session & Special symposium in basic EP, CardioRhythm 2011, Hong Kong. 2011.

Li G.R. and Dong X.L., Functional ion channels in stem cells., World J Stem Cells. 2011, 3(3): 19-24.

Li G.R. and Dong M., Pharmacology of cardiac potassium channels, Adv Pharmacol. San Diego, Calif, 2010, 59: 93-134.

Li G.R. and Dong M., Revisit of the Cardiac Inward Rectifier Potassium Current IK1, The Open Circulation & Vascular Journal. 2010, 3: 95-102.

Li G.R., 如何更有效地從中藥中發掘有效治療心血管疾病的藥物, 第十屆全國心血管藥理學術會議暨2010 （重慶）國際心血管疾病與藥物高峰論壇. 2010, p12.

Liu H., Yang L., Jin M.W., Sun H., Huang Y. and Li G.R., The selective estrogen receptor modulator raloxifene inhibits cardiac delayed rectifier potassium currents and voltage-gated sodium current without QTc interval prolongation. , Pharmacol Res. 2010, 62(5): 384-390.

Lu L., Li G.R. and Ballard H.J., Identification of channels on skeletal myoblasts that may contribute to acidosis-induced ATP release, J HK Coll Cardiol. 2010. 18(2): 64.

Su X.L., Wang Y., Zhang W., Zhao L.M., Li G.R. and Deng X.L., Insulin-mediated upregulation of K(Ca)3.1 channels promotes cell migration and proliferation in rat vascular smooth muscle., J Mol Cell Cardiol.. 2011, 51(1): 51-57.

Tao R., Sun H., Lau C.P., Tse H.F., Lee H.C. and Li G.R., Cyclic ADP ribose is a novel regulator of intracellular Ca(2+) oscillations in human bone marrow mesenchymal stem cells. , J Cell Mol Med. 2011, 15(12): 2684-96.

Tao R., Lee H.C. and Li G.R., Cyclic ADP ribose is a novel regulator of intracellular Ca2+ oscillations in human bone marrow mesenchymal stem cells, New Horizons in Calcium Signaling. Oct, 2010. Beijing, China. 2010, p173.

Wu H., Wu W. and Li G.R., Rate-dependent block of hkv1.5 channels and the molecular determinant by the natural flavone acacetin, J HK Coll Cardiol. 2010. 18(2): 78.

Wu H., Wu W., Lau C.P., Vanhoutte P.M.G.R. and Li G.R., Use-dependent block of hKv1.5 channels and the molecular determinant by the natural flavone acacetin, 16th Medical Research Conference, Department of Medicine, HKU. 2011, 17(1): 60.

Wu W., Lau C.P., Tse H.F. and Li G.R., Beta1 subunit-dependent modulation of BK channel by membrane cholesterol, J HK Coll Cardiol. 2010. 18(2): 65.

Wu W., Lau C.P., Tse H.F. and Li G.R., Effects of increased cholesterol level on BK channels, 16th Medical Research Conference, Department of Medicine, HKU. 2011, 17(1): 61.

Zhang X., Jin M., Sun H., Zhang S. and Li G.R., The calmodulin inhibitor N-(6-aminohexyl)-5-chloro-1-naphthalene sulphonamide directly blocks human ether à-go-go-related gene potassium channels stably expressed in human embryonic kidney 293 cells., Br J Pharmacol. 2010, 161(4): 872-884.

Zhang Y., Lau C.P., Tse H.F. and Li G.R., Expression of TrpC and TrpM channels in human atrial myocytes, J HK Coll Cardiol. 2010. 18(2): 71.

Zhang Y., Sun H., Tse H.F., Lau C.P. and Li G.R., Identification of transient receptor potential channels in human atrial myocytes, 16th Medical Research Conference, Department of Medicine, HKU. 2011, 17(1): 68.

Researcher : Li HY

List of Research Outputs

Xiao S., Cherny S.S., Li H.Y., Gao Y., Tso H.W., Lau K.S., Luk K.D.K., Sham P.C. and Kung A.W.C., Association Of Jag1 Gene And Its Variant Sequence With Bone Mineral Density And Osteoporotic Fractures: A Genome-wide Association Study And Follow-up Replication Studies, The HKSEMR Annual Scientific Meeting and Annual General Meeting, 21 November, Hong Kong. 2010.

Researcher : Li LSW

List of Research Outputs

Chan Y.H., Siu D.C.W., Li L.S.W., Lam T.H., Lau C.P. and Tse H.F., Abnormal Vascular Function In Pr Interval Prolongation: Novel Insights Into Mechanisms Of Adverse Cardiovascular Outcomes (Abstract and Oral Presentation), 3rd Asian Preventive Cardiology & Cardiac Rehabilitation Conference cum 8th Certificate Course in Cardiac Rehabilitation, 11-14 December 2010, Hong Kong. Hong Kong, Hong Kong College of Cardiology, 2010.

Chan Y.H., Lam T.H., Lau G.K.K., Yiu K.H., Siu D.C.W., Li L.S.W., Chan K.H.T., Tam S., Lau C.P. and Tse H.F., Dietary intake of phytoestrogen is associated with increased circulating endothelial progenitor cells in patients with cardiovascular disease, European Journal of Cardiovascular Prevention and Rehabilitation. 2011, 18(3): 360-368.

Lam L.T., McGrath C.P.J., Samaranayake L.P. and Li L.S.W., Evaluation of Oral Hygiene Interventions in Patients following Acute Stroke , Journal of Dental Research. Sage Publications, Inc., 2011, Vol. 90, Special Issue A: 2574.

Lam L.T., McGrath C.P.J., Samaranayake L.P. and Li L.S.W., Evaluation of oral hygiene interventions in patients following acute stroke/IADR Lion Dental Research Award: 89th General Session & Exhibition of the IADR, San Diego, Calif., USA, 2011, 2011.

Li X., Tse H.F., Yiu K.H., Li L.S.W. and Jin L.J., Effect of periodontal treatment on circulating CD34⁺ cells and peripheral vascular endothelial function: a randomized controlled trial, Journal of Clinical Periodontology. 2011, 38: 148-156.

Tse M.Y.M., Li L.S.W., Cheung R.T.F. and Kwok T.K., Impact of stroke on autonomic nervous system, Sixteenth Medical Research Conference. 2011, 17 (Suppl 1): 56.

Tse M.Y.M., Li L.S.W. and Cheung R.T.F., Post-stroke orthostatic hypotension, its pattern of recovery, Sixteenth Medical Research Conference. 2011, 17 (Suppl 1): 55.

Tso A.W.K., Lam T.K.Y., Xu A., Yiu K.H., Tse H.F., Li L.S.W., Law S.C., Cheung B.M.Y., Cheung R.T.F. and Lam K.S.L., Serum adipocyte fatty acid-binding protein is associated with ischemic stroke and early death, Neurology. 2011, 76(23): 1968-75.

Yiu Y.F., Chan Y.H., Yiu K.H., Siu D.C.W., Li L.S.W., Wong L.Y., Lee S.W.L., Tam S., Wong E.W.K., Cheung B.M.Y. and Tse H.F., Vitamin D deficiency is associated with depletion of circulating endothelial progenitor cells and endothelial dysfunction in patients with type 2 diabetes. , J Clin Endocrinol Metab. 2011, 96(5): E830-835.

Researcher : Li M

List of Research Outputs

Li M., Ho J.C.Y., Lai K.W.H., Au K.W., Xu A., Cheung B.M.Y., Lam K.S.L. and Tse H.F., Hypoadiponectinemia and its Impact on circulating endothelial progenitor cells in patients with type 2 diabetes - adiponectin and endothelial progenitor cells, Diabetes/Metab Res Rev. 2010, 27: 185-94.

Li M. and Cheung B.M.Y., Rise and fall of anti-obesity drugs, World J Diabetes. 2011, 2(2): 19-23.

Li M., Ho J.C.Y., Lai K.W.H., Au K.W., Xu A., Cheung B.M.Y., Lam K.S.L. and Tse H.F., The decrement in circulating endothelial progenitor cells (EPCs) in type 2 diabetes is independent of the severity of the hypoadiponectemia, Diabetes Metab Res Rev. 2011, 27(2): 185-194.

Ong K.L., Li M., Tso A.W.K., Xu A., Cherny S.S., Sham P.C., Tse H.F., Lam T.H., Cheung B.M.Y. and Lam K.S.L., Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese. , European Journal of Endocrinology. 2010, 163: 251-257.

Researcher : Li M

List of Research Outputs

Li M. and Cheung B.M.Y., Rise and fall of anti-obesity drugs, World J Diabetes. 2011, 2(2): 19-23.

Researcher : Li RA

Project Title:	Non-cell autonomous directed maturation of developmentally arrested hESC/iPSC-derived cardiomyocytes
Investigator(s):	Li RA
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2011

List of Research Outputs

Chen A., Lieu D.K., Freschauf L., Lew V., Sharma H., Wang J., Nguyen D., Karakikes I., Hajjar R.J., Gopinathan A., Botvinick E., Fowlkes C.C., Li R.A. and Khine M., Shrink-Film Configurable Multi-scale Wrinkles for Functional Cell Alignment Studies. , Advanced Materials. In press. . 2011.

Kong M.C.W., Poon N.Y.E., Yeung H.M., Rushing S.N., Chen G. and Li R.A., MicroRNA-21 promotes survival but not functional maturation of human embryonic stem cell derived cardiomyocytes (hESC-CMs), 16th MRC, HKU. 2010.

Kong M.C.W., Akar F.G. and Li R.A., Translational potential of human embryonic and induced pluripotent stem cells for myocardial repair: insights from experimental models, Thromb Haemost. 2010, 104: 30-38.

Li R.A. and Akar F.G., Cell Therapy for Ventricular Arrhythmias & Ventricular Arrhythmias in Cell Therapy. , In: Sam C. Dudley., 2011.

Li R.A., Convener for the field of Stem Cell & Regenerative Medicine in Hong Kong, appointed by the Research Grant Council of HK, Theme-based Research., Research Grant Council of HK, The University of Hong Kong. 2010.

Li R.A., Development of Stem Cell & Regenerative Medicine in Hong Kong: Heart Regeneration as a Case Study., Pathology, HKU. 2010.

Li R.A., Lieu D.K. and Poon N.Y.E., From the Electrophysiological Perspectives, In: Michael Sanguinetti., MicroRNA- and Pluripotent Stem Cell-based Heart Therapies. 2011.

Li R.A., Kong M.C.W. and Poon N.Y.E., Human pluripotent stem cells in cardiovascular research and regenerative medicine., Embryonic Stem Cells Book 2, 2011.

Li R.A., Panel Committee, Biomedical Sciences (nominated by Professors Lap-Chee Tsui and Paul Tam) of the Research Grant Council of HK., Research Grant Council of HK.. 2010.

Li R.A., Pluripotent Stem Cell Engineering. , HK University of Science and Technology. . 2010.

Li R.A., Kong M.C.W. and Poon N.Y.E., Pluripotent Stem Cell-Based Approaches for Myocardial Repair., Mol Pharm. In press., 2011.

Li R.A., Pluripotent Stem Cell-based Heart Regeneration. , Cardiovascular Center. UC Irvine.. 2010.

Li R.A., Pluripotent Stem Cell-based Heart Regeneration. , Harvard Stem Cell Institute. . 2010.

Li R.A., Pluripotent Stem Cell-based Heart Regeneration., Chinese University of Hong Kong Stem Cell Program. . 2010.

Li R.A. and Akar F.G., Promises and Hurdles, In: Fadi G. Akar, Ronald A. Li, Inducible Pluripotent Stem Cells as a disease model to study inherited arrhythmias. Drug Discov Today Dis Models. In press., 2011.

Li R.A., Promises and Hurdles, Modeling Diseases with Induced Pluripotent Stem Cells. Drug Discov Today Dis Models. In press., 2011.

Li R.A. and Costa K., Tissue Engineering of hESC/iPSC-derived Cardiomyocytes for Disease modeling and Drug Discovery, Drug Discov Today Dis Models. In press., 2011.

Liao S., Liu Y., Siu D.C.W., Zhang Y., Lai K.W.H., Au K.W., Lee Y.K., Li R.A. and Tse H.F., Proarrhythmic risk of embryonic stem cell-derived cardiomyocyte transplantation in infarcted myocardium, Heart Rhythm. 2010, 7(12): 1852-9.

Lieu D.K., Chan J.A.M.E.S. and Li R.A., SHG identification of PSC-Cms, Journal of Biophotonics. In press. . 2011.

Luna J.I., Ciriza J., Garcia-Ojeda M.E., Kong M.C.W., Herren A., Lieu D.K., Li R.A., Fowlkes C.C., Khine M. and McCloskey K.E., Multiscale biomimetic topography for the alignment of neonatal and embryonic stem cell-derived heart cells, Tissue Eng Part C Methods. 2011, 17 (5): 579-88.

Ng K.M., Chan Y.C., Lee Y.K., Lai W.H., Au K.W., Fung M.L., Siu D.C.W., Li R.A. and Tse H.F., Cobalt Chloride Pretreatment Promotes Cardiac Differentiation of Human Embryonic Stem Cells under atmospheric oxygen level. x, Cell Reprogramming. In press.. 2011.

Ng K.M., Chan Y.C., Lee Y.K., Lai W.H., Fung M.L., Siu D.C.W., Li R.A. and Tse H.F., Cobalt chloride pre-treatment enhances the calcium handling of human embryonic stem cells-derived cardiomyocytes, Differentiation, 80:S44 Suppl. 1, 2010.

Poon N.Y.E., Kong M.C.W., Yeung H.M., Rushing S.N., Li Y.S. and Li R.A., MiR-29b negatively regulates cell cycle activity of human embryonic stem cell-derived cardiomyocytes, 16th MRC, HKU. 2010.

Tam K.W., Li R.A., Chan Y.S. and Shum D.K.Y., Overcoming axon-restrictive chondroitin supphates with chondroitin sulphate lyases, Abstracts of 6^th Int’l Symp. on Healthy Aging: A New Golden Age: 56. 2011.

Tam K.W., Li R.A., Chan Y.S. and Shum D.K.Y., Use of chondroitin sulphate lyase subtypes to overcome molecular barriers of reactive glia: Implication for nerve regeneration, Proceedings of CSFR Neuroscience Summit, p. 32-33. [Beijing. Aug. 20-22, 2010]. 2010.

Tam K.W., Li R.A., Chan Y.S. and Shum D.K.Y., Use of chondroitin sulphate lyases in combination for achieving maximal activity: Implication for nerve regeneration, Abstracts of Joint Scientific Meeting of HK Society of Neurosciences and Biophysical Society of HK: 60-61. 2010.

Wang X., Chena S., Kong M.C.W., Wang Z., Costa K.D., Li R.A. and Sun D., Enhanced cell sorting and manipulation with combined optical tweezer and microfluidic chip technologies., Lab on a Chip. In press. . 2011.

Zhang J., Calafiore M., Zeng Q., Zhang X., Huang Y., Li R.A., Deng W. and Zhao M., Electrically Guiding Migration of Human Induced Pluripotent Stem Cells. , Stem Cell Rev. Mar 5. [Epub ahead of print]. 2011.

Researcher : Li YS

List of Research Outputs

Poon N.Y.E., Kong M.C.W., Yeung H.M., Rushing S.N., Li Y.S. and Li R.A., MiR-29b negatively regulates cell cycle activity of human embryonic stem cell-derived cardiomyocytes, 16th MRC, HKU. 2010.

Researcher : Lian Q

Project Title:	Comparing differentiation propensity among mescenchymal stem cells derived from sources of human embryonic stem cell lines, term placenta and bone morrow
Investigator(s):	Lian Q, Tse HF
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	10/2008
Completion Date:	10/2010

Project Title:	Generation of corneal epithelial stem cells from human induced pluripotent stem cells (iPSC) and application for corneal epithelial tissue engineering
Investigator(s):	Lian Q, Tse HF, Wong DSH, Siu DCW, Yu CS
Department:	Medicine
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2010
Completion Date:	12/2011

Project Title:	Generation of mesenchymal stem cells from human induced pluripotent stem cells (iPS) for the treatment of limb ishcemia
Investigator(s):	Lian Q, Tse HF
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	01/2010
Completion Date:	12/2010

Project Title:	The Roles of Mesenchymal Stem Cell Produced Stromal Cell-derived Factor-1 and Neuregulin-1 for Cardiac Progenitor Cell-mediated Myocardial Regeneration in Response to Heart Infarction
Investigator(s):	Lian Q, Siu DCW, Tse HF
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2010

Project Title:	Functional Characterization of human iPSC- derived mesenchymal stem cells with cardiomyocyte potential
Investigator(s):	Lian Q, Tse HF
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	02/2011

List of Research Outputs

Lee Y.K., Ng K.M., Lai K.W.H., Chan Y.C., Lau Y.M., Lian Q., Tse H.F. and Siu D.C.W., Calcium Homeostasis in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes., Stem Cell Reviews and Reports. 2011.

Siu D.C.W., Liao S., Liu Y., Lian Q. and Tse H.F., Stem cells for myocardial repair, Thrombosis and Hemostasis. 2010, 104(1): 6-12.

Zhang J., Chan Y.C., Ho J.C.Y., Siu D.C.W., Lian Q. and Tse H.F., Proliferation of Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells via Ether à go-go 1 (hEAG1) Potassium Channel., Journal of Cellular and Molecular Medicine (Under Review). 2011.

Researcher : Liang RHS

List of Research Outputs

Chan K.S., Au W.Y., Wong C.Y., Liang R.H.S., Leung A.Y.H., Kwong Y.L. and Khong P.L., Metabolic activity measured by F-18 FDG PET in NK-cell lymphoma compared to aggressive B- and T-cell lymphomas, Clinical Nuclear Medicine . 2010, 35: 571-575.

Chim J.C.S., Sim J.P., Chan C.C., Kho B.C., Chan J.C., Wong L.G., Law M., Liang R.H.S. and Kwong Y.L., Impact of JAK2V617F mutation on thrombosis and myeloid transformation in essential thrombocythemia: a multivariate analysis by Cox regression in 141 patients , Haematology. 2010, 15(4): 187-92.

Fung T.K., Chung I.S., Liang R.H.S. and Leung A.Y.H., Role of a novel zebrafish nup98 during embryonic development, Experimental Hematology. 2010, Epub.

Hung I.F.N., Leung A.Y.M., Chu D.W.S., Leung Y.P., Cheung T..., Chan C.K., Lam C.L.K., Liu S...H..., Chu C...M..., Ho P.L., Chan S.S.C., Lam T.H., Liang R.H.S. and Yuen K.Y., Prevention of acute myocardial infarction and stroke among elderly persons by dual pneumococcal and influenza vaccination: a prospective cohort study, Clinical Infectious Diseases. 2010, 51(9): 1007-1016.

Lam B., Wong M.K.Y., Lu K.H., Au W.Y., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Liang R.H.S., Lam W.K., Ip M.S.M. and Lie A.K.W., Effects of Azithromycin in bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation – a randomized double-blinded placebo-controlled study, Bone Marrow Transplantation. 2011, Epub ahead of print.

Lam C.L.D., Lam B., Wong M.K.Y., Lu K.H., Au W.Y., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Liang R.H.S., Lam W.K., Ip M.S.M. and Lie A.K.W., Effects of Azithromycin in bronchiolitis obliterans syndrome after hematopoietic SCT-a randomized double-blinded placebo-controlled study, Bone marrow transplantation. 2011, Epub ahead of print.

Ma C.H., Chung I.S., Liang R.H.S. and Leung A.Y.H., A DEAB-sensitive aldehyde dehydrogenase regulates hematopoietic stem and progenitor cells development during primitive hematopoiesis in zebrafish embryos, Leukemia. Nature Publishing Group, 2010, 24: 2090-2099.

Wong K.Y., Liang R.H.S., So J.C.C., Jin D., Costello J.F. and Chim J.C.S., Epigenetic silencing of MIR203 in multiple myeloma, Br J Haematol. 2011, [Epub ahead of print].

Wong K.Y., Liang R.H.S., So C.H.I.-.C.H.I.U., Qi Y.A.N.T.I.N.G., Jin D.O.N.G.-.Y.A.N., Costello J.O.S.E.P.H. .F... and Chim J.C.S., Epigenetic silencing of miR-203 in multiple myeloma, Br J Haematol. 2011, [Epub ahead of print].

Researcher : Liao S

List of Research Outputs

Liao S., Liu Y., Siu D.C.W., Zhang Y., Lai K.W.H., Au K.W., Lee Y.K., Li R.A. and Tse H.F., Proarrhythmic risk of embryonic stem cell-derived cardiomyocyte transplantation in infarcted myocardium, Heart Rhythm. 2010, 7(12): 1852-9.

Siu D.C.W., Liao S., Liu Y., Lian Q. and Tse H.F., Stem cells for myocardial repair, Thrombosis and Hemostasis. 2010, 104(1): 6-12.

Yue W., Chong B.H., Zhang X., Liao S., Jim M.H., Kung A.W.C., Tse H.F. and Siu D.C.W., Hyperthyroidism-induced left ventricular diastolic dysfunction: implication in hyperthyroidism-related heart failure, Clin Endocrinol (Oxf). 2011, 74(5): 636-43.

Researcher : Lie AKW

List of Research Outputs

Chan T.S., Au W.Y., Lam K., Lam Y.F., So J.C.C., Leung A.Y.H., Tse E.W.C., Lie A.K.W. and Kwong Y.L., Donor cell leukaemia after allogeneic haematopoietic SCT followed by prolonged thalidomide maintenance for multiple myeloma, Bone Marrow Transplant. 2011, [Epub ahead of print].

Lam B., Wong M.K.Y., Lu K.H., Au W.Y., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Liang R.H.S., Lam W.K., Ip M.S.M. and Lie A.K.W., Effects of Azithromycin in bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation – a randomized double-blinded placebo-controlled study, Bone Marrow Transplantation. 2011, Epub ahead of print.

Lam C.L.D., Lam B., Wong M.K.Y., Lu K.H., Au W.Y., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Liang R.H.S., Lam W.K., Ip M.S.M. and Lie A.K.W., Effects of Azithromycin in bronchiolitis obliterans syndrome after hematopoietic SCT-a randomized double-blinded placebo-controlled study, Bone marrow transplantation. 2011, Epub ahead of print.

Researcher : Lin H

List of Research Outputs

Ma C.H., Chung I.S., Lin H., Yang D. and Leung A.Y.H., Methionine aminopeptidase II in zebrafish definitive hematopoiesis, Hong Kong Society of Developmental Biology. 2011.

Researcher : Lin M

List of Research Outputs

Tang S.C.W., Lin M., Tam S., Au W.S., Ma K.M., Yap D.Y., Ho Y.W. and Lai K.N., Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-labeled pilot study. Proceedings of the World Congress of Nephrology April 2011, J Am Soc Nephrolol. 2010.

Tang S.C.W., Lin M., Tam S., Au W.S., Ma M.K., Yap D.Y., Ho Y.W. and Lai K.N., Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-labeled pilot study, Nephrology Dialysis Transplantation. 2011.

Tang S.C.W., Chan Y.Y., Leung J.C.K., Cheng A.S., Lin M., Lan H.Y. and Lai K.N., Differential effects of advanced glycation end-products on renal tubular cell inflammation, Nephrology (Carlton, Vic). 2011, 16(4): 417-25.

Researcher : Liu H

List of Research Outputs

Ho W.L., Ho W.M., Liu H., So H.F., Chan K.H., Ramsden D.B. and Ho S.L., Functional studies of neuronal mitochondrial uncoupling proteins: implication in the pathology of Parkinson’s disease, The Hong Kong Neurological Society - Annual Scientific Meeting 2010; Kowloon Shangri-La Hotel, Hong Kong; 2010.. 2010.

Ho W.L., Ho W.M., So H.F., Liu H., Chan K.H., Ramsden D.B. and Ho S.L., Manipulation of mitochondria functions via uncoupling proteins as novel strategy against energy deficiency and neurodegeneration, Croucher Advanced Study Institute on Mitochondrial Stress in Diabetes and Aging, 29 April, 2011, organized by the Croucher Foundation; HBHA, University of Hong Kong.. 2011.

Ho W.L., Ho W.M., So H.F., Liu H., Chan K.H., Ramsden D.B. and Ho S.L., Potential role of mitochondrial uncoupling protein-4 (UCP4) in energy supply during neuronal differentiation , 16th Medical Research Conference 2011, University of Hong Kong. 2011, 17(1): suppl 1;: 31.

Ho W.L., Ho W.M., Zhang W., Yiu C.W., Liu H., Chan K.H., Ramsden D.B. and Ho S.L., Role of mitochondrial uncoupling protein-4 (UCP4) in energy supply during neuronal differentiation, EMBO Meeting 2010, Barcelona, Spain. 2010.

Ho W.M., Ho W.L., Zhang W., Liu H., Kwok H.H., Yiu C.W., Chan K.H., Kung M.H.W., Ramsden D.B. and Ho S.L., Activation of c-Rel mediates neuroprotection via mitochondrial uncoupling protein-4 under NF-kB pathways, EMBO Meeting 2010, Barcelona, Spain (4-7 Sept, 2010). 2010.

Researcher : Liu H

List of Research Outputs

Researcher : Liu Y

List of Research Outputs

Liao S., Liu Y., Siu D.C.W., Zhang Y., Lai K.W.H., Au K.W., Lee Y.K., Li R.A. and Tse H.F., Proarrhythmic risk of embryonic stem cell-derived cardiomyocyte transplantation in infarcted myocardium, Heart Rhythm. 2010, 7(12): 1852-9.

Siu D.C.W., Liao S., Liu Y., Lian Q. and Tse H.F., Stem cells for myocardial repair, Thrombosis and Hemostasis. 2010, 104(1): 6-12.

Researcher : Liu Y

List of Research Outputs

Siu D.C.W., Liao S., Liu Y., Lian Q. and Tse H.F., Stem cells for myocardial repair, Thrombosis and Hemostasis. 2010, 104(1): 6-12.

Researcher : Lo WK

List of Research Outputs

Yip T.P.S., Tse K.C., Ng F.S.K., Hung I.F.N., Lam M.F., Tang S.C.W., Lui S.L., Lai K.N., Chan D.T.M. and Lo W.K., Clinical course and outcomes of single-organism Enterococcus peritonitis in dialysis patients, Peritoneal Dialysis International. 2011, 31.

Researcher : Lo Y

List of Research Outputs

Mok T.M.Y., Wu H., Lo Y. and Lau W.C.S., Serum IL-17 and IL-23 to Th1/Th2 cytokines and disease activity in systemic lupus erythematosus., The Journal of Rheumatology. 2010, 37(10): 2046-2052.

Mok T.M.Y., Lau W.C.S., Chiu S.S.H., Tso A.W.K., Lo Y. and Law S.C., Systemic sclerosis is an independent risk factor for increased coronary artery calcium deposition, Arthritis Rheum. 2011, 63(5): 1387-95.

Mok T.M.Y., Wu H., Lo Y. and Lau W.C.S., The relation of interleukin 17 (IL-17) and IL-23 to Th1/Th2 cytokines and disease activity in systemic lupus erythematosus., The Journal of Rheumatology. 2010, 37(10): 2046-2052.

Researcher : Lo YYC

Project Title:	Case-based small group learning: exploring Family Medicine teachers’ perceptions and needs to develop recommendations for tutor training and support
Investigator(s):	Lo YYC, Chin WY, Chen JY
Department:	Med - Family Medicine Unit
Source(s) of Funding:	Leung Kau Kui Research and Teaching Endowment Fund - Teaching Grants
Start Date:	06/2008
Completion Date:	08/2010

List of Research Outputs

Wong T.W.T., Lam W.W.T., Lo Y.Y.C., Fabrizio C.S., Chan M., Or A. and Fielding R., Informational gathering by patient and companion in the first breast cancer consultation (abstract and poster presentation), The 2nd Meeting of East Asia Psycho-Oncology Society, 23-24 August 2010, Hong Kong. Hong Kong, School of Public Health, University of Hong Kong, 2010, 30.

Researcher : Lu KH

List of Research Outputs

Lam B., Wong M.K.Y., Lu K.H., Au W.Y., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Liang R.H.S., Lam W.K., Ip M.S.M. and Lie A.K.W., Effects of Azithromycin in bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation – a randomized double-blinded placebo-controlled study, Bone Marrow Transplantation. 2011, Epub ahead of print.

Lam C.L.D., Lam B., Wong M.K.Y., Lu K.H., Au W.Y., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Liang R.H.S., Lam W.K., Ip M.S.M. and Lie A.K.W., Effects of Azithromycin in bronchiolitis obliterans syndrome after hematopoietic SCT-a randomized double-blinded placebo-controlled study, Bone marrow transplantation. 2011, Epub ahead of print.

Researcher : Lui SL

List of Research Outputs

Ma M.K.M., Yung S.S.Y., Yim A.S.Y., Ng K.F., Tang C.S.O., Lui S.L. and Chan D.T.M., Low- versus conventional-level of glucose peritoneal dialysis regimes - comparison of inflammatory and fibrotic mediators in peritoneal dialysate, World Congress of Nephrology 2011.

Yip T.P.S., Tse K.C., Ng F.S.K., Hung I.F.N., Lam M.F., Tang S.C.W., Lui S.L., Lai K.N., Chan D.T.M. and Lo W.K., Clinical course and outcomes of single-organism Enterococcus peritonitis in dialysis patients, Peritoneal Dialysis International. 2011, 31.

Researcher : Luk JKH

List of Research Outputs

Chu L.W., Luk J.K.H., Hui E., Chiu P.K.C., Chan S.Y., Kwan S.M., Kwok T., Lee D. and Woo J., Advance directive and end-of-life care preferences among Chinese nursing home residents in Hong Kong, J Am Med Dir Assoc. . 2011, 12(2): 143-52.

Luk J.K.H., Chiu P.K.C. and Chu L.W., Gender differences in rehabilitation outcomes among older Chinese patients, Arch Gerontol Geriatr.. 2011, 52(1): 28-32.

Researcher : Luk TH

List of Research Outputs

Yan G., Wang M.M., Yue W., Luk T.H., Dai Y.L.E., Siu D.C.W., Yiu K.H., Lee S.W.L. and Tse H.F., Coenzyme Q10 Supplementation Improves Left Ventricular Torsion In Patients With Ischemic Cardiomyopathy, AHA. 2010.

Researcher : Ma CH

Project Title:	Which aldehyde dehydrogenase isoform(s) is/are important for primitive hematopoiesis during zebrafish embryonic development
Investigator(s):	Ma CH, Leung AYH
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	08/2009
Completion Date:	07/2010

Project Title:	ISEH 39th ANNUAL SCIENTIFIC MEETING THE ROLE OF METHIONINE AMINOPEPTIDASE II IN DEFINITIVE HEMATOPOIESIS IN ZEBRAFISH EMBRYOS
Investigator(s):	Ma CH
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	09/2010
Completion Date:	09/2010

List of Research Outputs

Ma C.H., Chung I.S., Liang R.H.S. and Leung A.Y.H., A DEAB-sensitive aldehyde dehydrogenase regulates hematopoietic stem and progenitor cells development during primitive hematopoiesis in zebrafish embryos, Leukemia. Nature Publishing Group, 2010, 24: 2090-2099.

Ma C.H., Chung I.S., Lin H., Yang D. and Leung A.Y.H., Methionine aminopeptidase II in zebrafish definitive hematopoiesis, Hong Kong Society of Developmental Biology. 2011.

Researcher : Ma J

List of Research Outputs

Ma J., Wang J., Zhang W., Zou B., Chen W., Lam S.C., Chen M., Pang R.W.C., Tan V.P.Y., Hung I.F.N., Lan H.Y., Wang Q. and Wong B.C.Y., Promoter hypermethylation and histone hypoacetylation contribute to Pancreatic-duodenal homeobox 1 (PDX1) silencing in gastric cancer., Carcinogenesis. 2010, 31(9): 1552-60.

Researcher : Mak JCW

Project Title:	Role of transforming growth factor-beta1 variants in susceptibility to tuberculosis in Hong Kong Chinese population
Investigator(s):	Mak JCW, Chan MMW
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2005

Project Title:	Effects of intermittent hypoxia and/or cigarette smoking on endothelial injury in vivo - relevant to obstructive sleep apnea
Investigator(s):	Mak JCW, Ip MSM
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2008
Completion Date:	03/2011

Project Title:	Pre- and post-operation sputum and serum tumor markers in non-small cell lung cancer patients
Investigator(s):	Mak JCW, Lam B
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2009
Completion Date:	03/2011

Project Title:	Involvement of serotoninergic system in cigarette smoke-induced inflammatory responses in human airway epithelial cells
Investigator(s):	Mak JCW
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2010
Completion Date:	04/2011

Project Title:	Effects of cigarette smoke on regulation of the expression of adiponectin and its receptors in airway cells
Investigator(s):	Mak JCW, Ip MSM
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2010

Project Title:	Signaling pathways on intermittent hypoxia-induced oxidative stress in human EAhy 926 endothelial cell line
Investigator(s):	Mak JCW
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2011

List of Research Outputs

Chan C.H., Leung V.O.Y., Lam C.L.D., Mak J.C.W., Ip M.S.M., Freeman C. and Shum D.K.Y., Sulfated maltoheptaose is a potential therapeutic in reducing neutrophilic inflammation in a cigarette smoke-induced rat model of chronic obstructive pulmonary disease, American Society for Matrix Biology, 2010 Meeting, Charlecton, SC, USA. Oct 24-27. 2010.

Chan C.H., Lam C.L.D., Mak J.C.W., Ip M.S.M., Freeman C. and Shum D.K.Y., Use of sulfated maltoheptaose to lower neutrophilic inflammation in a rat model of cigarette smoke-induced chronic obstructive pulmonary disease , Sixth International Symposium on Healthy Aging: “A New Golden Age” 5-6 March . 2011.

Chan K.H., Yeung S.C., Yao T., Ip M.S.M., Cheung A.H.K., Chan M.M.W. and Mak J.C.W., Elevated Plasma Adiponectin Levels In Patients With Chronic Obstructive Pulmonary Disease, Internatioanl Journal Of Tuberculosis And Lung Disease. 2010, 14: 1193-1200.

Han Q., Yeung S.C., Ip M.S.M. and Mak J.C.W., Intermittent hypoxia enhances inflammation and oxidative stress in Eahy926 endothelial cells via suppression of HO-1 expression, American Journal of Respiratory and Critical Care Medicine. 2011, 183: A2475.

Han Q., Yeung S.C., Ip M.S.M. and Mak J.C.W., Intermittent hypoxia enhances oxidative and inflammatory stresses in EAHY926 endothelial cells, Sixth International Symposium of Healthy Aging "A New Golden Age" 5-6 March 2011.

Han Q., Yeung S.C., Ip M.S.M. and Mak J.C.W., Role of HO-1 in intermittent hypoxia-induced inflammation in EAhy926 endothelial cell line, Journal of Pharmacological Sciences. 2011, 115: 158P.

Lau K.W., Chan K.H., Yeung S.C., Ip M.S.M. and Mak J.C.W., Effects of cigarette smoke exposure on serum 5-HT levels in rats, American Journal of Respiratory and Critical Care Medicine. 2011, 183: A2454.

Researcher : Mak W

List of Research Outputs

Chang R.S.K., Mak W., Cheung R.T.F. and Ho S.L., Risk factors, clinical presentation and prognosis of perioperative stroke: a retrospective case-control study, 63rd Annual Meeting of the American Academy of Neurology. 2011, 76 (Suppl 4): A60.

Gao J., Wong W., Mak W. and Cheung R.T.F., An event-related potential study on the information flow during prospective memory interference, Sixteenth Medical Research Conference. 2011, 17 (Suppl 1): 26.

Kwan M.W., Mak W., Cheung R.T.F. and Ho S.L., Ischemic stroke related to intracranial branch atheromatous disease and comparison with large and small artery diseases, J Neurol Sci. . J Neurol Sci., 2011, 303(1-2):: 80-4.

Researcher : Mok TMY

Project Title:	Polarization of Th17 cells by activated dendritic cells in systemic lupus erythematosus
Investigator(s):	Mok TMY
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2010
Completion Date:	04/2011

Project Title:	The role of matrix metalloproteinases and tissue inhibitor of metalloproteinases in neuropsychiatric lupus
Investigator(s):	Mok TMY
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	04/2011

List of Research Outputs

Jin O., Kavikondala S., Sun L.Y., Gu J.R., Fu R., Mok T.M.Y., Chan W.K., Yeung J.S.L., Nie Y. and Lau W.C.S., Abnormalities in circulating plasmacytoid dendritic cells in patients with systemic lupus erythematosus., Arthritis Research & Therapy. 2010, 12(4): R137.

Mok T.M.Y., Yiu K.H., Wong C.Y., Qiuwaxi J., Lai W.H.K., Wong R.W.S., Tse H.F. and Lau W.C.S., Low circulating level of CD133+KDR+cells in patients with systemic sclerosis., Clinical and Experimental Rheumatology. 2010, 28(5 Suppl 62): S19-25.

Mok T.M.Y., Pathogenesis of neuropsychiatric lupus, The 14th Congress of Asia Pacific League of Associations of Rheumatology 2010, Hong Kong. 2010.

Mok T.M.Y., Pro-inflammatory cytokines in systemic lupus erythematosus, The 14th Congress of Asia Pacific League of Associations of Rheumatology 2010, Hong Kong. 2010.

Mok T.M.Y., Wu H., Lo Y. and Lau W.C.S., Serum IL-17 and IL-23 to Th1/Th2 cytokines and disease activity in systemic lupus erythematosus., The Journal of Rheumatology. 2010, 37(10): 2046-2052.

Mok T.M.Y., Lau W.C.S., Chiu S.S.H., Tso A.W.K., Lo Y. and Law S.C., Systemic sclerosis is an independent risk factor for increased coronary artery calcium deposition, Arthritis Rheum. 2011, 63(5): 1387-95.

Mok T.M.Y. and Lau W.C.S., The burden and measurement of cardiovascular disease in systemic sclerosis. , Nature Reviews Rheumatology. 2010, 6(7): 430-434.

Mok T.M.Y., Wu H., Lo Y. and Lau W.C.S., The relation of interleukin 17 (IL-17) and IL-23 to Th1/Th2 cytokines and disease activity in systemic lupus erythematosus., The Journal of Rheumatology. 2010, 37(10): 2046-2052.

Shen N., Fu Q., Deng Y., Qian X., Zhao J., Kaufman K.M., Wu Y.L., Yu C.Y., Tang Y., Chen J.Y., Yang W., Wong M., Kawasaki A., Tsuchiya N., Sumida T., Kawaguchi Y., Howes H.S., Mok T.M.Y., Bang S.Y., Liu F.L., Chang D.M., Takasaki Y., Hashimoto H., Harley J.B., Guthridge J.M., Grossman J.M., Cantor R.M., Song Y.W., Bae S.C., Chen S., Hahn B.H., Lau Y.L. and Tsao B.P., Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus, Proceeding of the National Academy of Sciences USA. 2010, 2010: 107(36).

Yiu K.H., Wang S., Mok T.M.Y., Ooi G.C., Khing P.L., Lau C.S. and Tse H.F., J Rheumatol, Relationship between cardiac valvular and arterial calcification in patients with rheumatoid arthritis and systemic lupus erythematosus. 2011, 38: 621-7.

Yiu K.H., Tse H.F., Mok T.M.Y. and Lau C.S., Nat Rev Rheumatol, Ethnic difference in the cardiovascular risk in patients with rheumatic disease: Focus on Asians. 2011, In Press.

Yiu K.H., Wang S., Mok T.M.Y., Ooi C.G.C., Khong P.L., Lau C.S. and Tse H.F., Relationship between cardiac valvular and arterial calcification in patients with rheumatoid arthritis and systemic lupus erythermatosus, Journal of Rheumatology . 2011, 38: 621-627.

Zhang Y., Yang W., Mok C.C., Chan T.M., Wong R.W.S., Mok T.M.Y., Lee K.W., Wong S.N., Leung A.M.H., Lee T.L., Ho M.H.K., Lee P.P.W., Wong W.H.S., Yang J., Zhang J., Wong C.M., Ng I.O.L., Garcia-Barcelo M.M., Cherny S.S., Tam P.K.H., Sham P.C., Lau W.C.S. and Lau Y.L., Two missense variants in UHRF1BP1 are indpendently associated with systemic lupus erythematosus in Hong Kong Chinese, Genes and Immunity. 2011, 12(3): 231-234.

Zhu J., Mak H.K.F., Mok T.M.Y., Chan Q. and Lau W.C.S., Role of functional neuroimaging in Neuropsychiatric (NP) Systemic Lupus Etythematosus (SLE) – a combined study of Diffusion Tensor Imaging (DTI) and MR Spectroscopy (MRS) at 3 Tesla Magnetic Resonance Imaging, 49th Annual Meeing ASNR, Seattle, June 4 to 10 (oral).. 2011.

Researcher : Ng FSK

List of Research Outputs

Yip T.P.S., Tse K.C., Ng F.S.K., Hung I.F.N., Lam M.F., Tang S.C.W., Lui S.L., Lai K.N., Chan D.T.M. and Lo W.K., Clinical course and outcomes of single-organism Enterococcus peritonitis in dialysis patients, Peritoneal Dialysis International. 2011, 31.

Researcher : Ng KF

List of Research Outputs

Ma M.K.M., Yung S.S.Y., Yim A.S.Y., Ng K.F., Tang C.S.O., Lui S.L. and Chan D.T.M., Low- versus conventional-level of glucose peritoneal dialysis regimes - comparison of inflammatory and fibrotic mediators in peritoneal dialysate, World Congress of Nephrology 2011.

Researcher : Ng KM

Project Title:	Role of APOA1 in the cardiac differentiation of pluripotent stem cells
Investigator(s):	Ng KM, Siu DCW, Tse HF
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	09/2010

Project Title:	The 16th International Conference of the International Society of Differentiation (ISD2010) Cobalt Chloride Pre-treatment Enhances the Calcium Handling of Human Embryonic Stem Cells-derived Cardiomyocytes.
Investigator(s):	Ng KM
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	11/2010
Completion Date:	11/2010

List of Research Outputs

Lee Y.K., Ng K.M., Lai K.W.H., Chan Y.C., Lau Y.M., Lian Q., Tse H.F. and Siu D.C.W., Calcium Homeostasis in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes., Stem Cell Reviews and Reports. 2011.

Ng K.M., Chan Y.C., Lee Y.K., Lai W.H., Au K.W., Fung M.L., Siu D.C.W., Li R.A. and Tse H.F., Cobalt Chloride Pretreatment Promotes Cardiac Differentiation of Human Embryonic Stem Cells under atmospheric oxygen level. x, Cell Reprogramming. In press.. 2011.

Ng K.M., Lee Y.K., Lai K.W.H., Chan Y.C., Fung M.L., Tse H.F. and Siu D.C.W., Exogenous Expression of Human apoA-I Enhances Cardiac Differentiation of Pluripotent Stem Cells., PLoS One. 2011.

Ng K.T., Li J., Ng K.M., Tipoe G.L., Leung W.K. and Fung M.L., Expression of hypoxia-inducible factor-1a in human periodontal tissue, Journal of Periodontology. 2011, 82: 136-141.

Tam K.V., Lau K.W., Lee T.O., Chu J.Y.S., Ng K.M., Fournier A. and Chow B.K.C., Origin of Secretin Receptor Precedes the Advent of Tetrapoda: Evidence on the Separated Origins of Secretin and Orexin, PLoS One. 2011, E19384.

Zhou T., Benda C., Duzinger S., Huang Y., Li X., Li Y., Guo X., Cao G., Chen S., Hao L., Chan Y.C., Ng K.M., Ho J.C.Y., Wieser M., Wu J., Redl H., Tse H.F., Grillari J., Grillari-Voglauer R., Pei D. and Esteban M.A., Generation of induced pluripotent stem cells from urine., Journal of the American Society of Nephrology. 2011.

Researcher : Ng L

List of Research Outputs

Chen W.J., Chow A.K., Ng L., Poon R.T.P., Wong B.C.Y. and Pang R.W.C., Identification of CD44+ Cancer Cells in Gastric Cancer by Chemotherapeutic Enrichment, Submitted. 2010.

Chow A.K., Cheng N.M., Ng L., Chu A.C.Y., Poon R.T.P. and Pang R.W.C., Anti-tumor Efficacy of Human Recombinant Arginase in Combination with Chemotherapeutic Agents in Human Hepatocellular Carcinoma, Submitted. 2010.

Chow A.K., Poon R.T.P., Ng L., Chiu L., Cheng D., Ng R.L. and Pang R.W.C., Identification and Characterization of Cancer Initiating Cells in Pleural Effusions of Liver Cancer Patients., Submitted. 2010.

Researcher : Ng MMT

List of Research Outputs

Seto W.K., Ng M.M.T., Chan P., Ng I.O.L., Cheung S.C.W., Hung I.F.N., Yuen R.M.F. and Lai C.L., Ketamine-induced cholangiopathy: a case report., Am J Gastroenterol. 2011, 106(5): 1004-5.

Researcher : Nie Y

List of Research Outputs

Jin O., Kavikondala S., Sun L.Y., Gu J.R., Fu R., Mok T.M.Y., Chan W.K., Yeung J.S.L., Nie Y. and Lau W.C.S., Abnormalities in circulating plasmacytoid dendritic cells in patients with systemic lupus erythematosus., Arthritis Research & Therapy. 2010, 12(4): R137.

Researcher : Ong KL

List of Research Outputs

Chen C., Tso A.W.K., Cheung B.M.Y., Ong K.L., Wat N.M.S., Edward D J.A.N.U.S., Xu A. and Lam K.S.L., Circulating Pigment Epithelium-Derived Factor Levels and the Risk of Hypertension in a Community-based Study., 16th Medical Research Conference, The University of Hong Kong. 2011.

Chen C., Tso A.W.K., Law S.C., Cheung B.M.Y., Ong K.L., Wat N.M.S., Janus E.D., Xu A. and Lam K.S.L., Plasma Level of Pigment Epithelium-Derived Factor Is Independently Associated with the Development of the Metabolic Syndrome in Chinese Men: A 10-Year Prospective Study. , J Clin Endocrinol Metab.. 2010, 95: 5074-81.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Association of a genetic variant in adrenomedullin gene with its plasma level , Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Cheung B.M.Y., Ong K.L., Jiang C.Q., Liu B., Jin Y.L., Tso A.W.K., Tam S., Wong K.S., Tomlinson B., Lin J.M., Yue X.J., Lam K.S.L., Lam T.H. and Thomas G.N., Association of a genetic variant in the apolipoprotein A5 gene with the metabolic syndrome in Chinese, Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Cheung B.M.Y., Ong K.L., Xu A., Lam T.H. and Lam K.S.L., Association of genetic variants in gene encoding lipocalin-2 with plasma alanine aminotransferase and aspartate aminotransferase, Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Gamma-glutamyl transaminase level predicts the development of hypertension., Poster Presentation at the 23rd Scientific Meeting of the International Society of Hypertension, Vancouver. 2010.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Gamma-glutamyl transferase level predicts the development of hypertension in Hong Kong Chinese, Clin Chim Acta. 2011, 412(15-16): 1326-1331.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Lam T.H. and Lam K.S.L., Increasing prevalence of hypertension and central obesity in the Hong Kong cardiovascular risk factor prevalence study, Basic & Clinical Pharmacology & Toxicology. Presented at the 10th Congress of the European Association for Clinical Pharmacology and Therapeutics, Budapest. 2011, 109 (Suppl. 1): 108.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Lam T.H. and Lam K.S.L., Increasing prevalence of hypertension in Hong Kong Cardiovascular Risk Factor Prevalence Study: Role of general and central obesity, Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Thomas G.N., Lam T.H. and Lam K.S.L., Mendelian randomisation analysis suggests that plasma interleukin-6 is raised in hypertension but does not cause its development, Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Plasma adrenomedullin level is related to plasma interleukin-6 and a polymorphism in the adrenomedullin gene, Basic & Clinical Pharmacology & Toxicology. Presented at the 10th Congress of the European Association for Clinical Pharmacology and Therapeutics, Budapest. 2011, 109 (Suppl. 1): 102-103.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Role of genetic variants in gene encoding lipocalin-2 in the development of elevated blood pressure, Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Cheung B.M.Y. and Ong K.L., The Challenge of Managing Hypertension. In: Finkel ML, ed., Public Health in the 21st Century. Santa Barbara, CA: Praeger Publishing. 2010.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Lam K.S.L., Cherny S.S. and Sham P.C., Using glycosylated haemoglobin to define the metabolic syndrome in United States adults, Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Lam K.S.L., Cherny S.S. and Sham P.C., Using glycosylated hemoglobin to define the metabolic syndrome in United States adults. , Oral Presentation at the 23rd Scientific Meeting of the International Society of Hypertension, Vancouver. 2010.

Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Ong K.L., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., Genetic variants associated with persistent central obesity and the metabolic syndrome in a 12-year longitudinal study, Euro J Endocrinol . 2011, 164: 381-8.

Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Lam T.H., Cheung B.M.Y. and Lam K.S.L., A genetic variant in the gene encoding adrenomedullin predicts the development of dysglycemia over 6.4 years in Chinese, Clin Chim Acta. 2010, 412: 353-7.

Ong K.L., Cheung B.M.Y., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Association of a genetic variant in adrenomedullin gene with its plasma level., Oral Presentation at the Annual Scientific Meeting of the Hong Kong Society of Endocrinology, Metabolism and Reproduction, Hong Kong. 2010.

Ong K.L., Jiang C.Q., Liu B., Jin Y.L., Tso A.W.K., Tam S., Wong K.S., Tomlinson B., Cheung B.M.Y., Lin J.M., Yue X.J., Lam K.S.L., Lam T.H. and Thomas G.N., Association of a genetic variant in the apolipoprotein A5 gene with the metabolic syndrome in Chinese, Clin Endocrinol (Oxf). 2010, 74: 206-13.

Ong K.L., Li M., Tso A.W.K., Xu A., Cherny S.S., Sham P.C., Tse H.F., Lam T.H., Cheung B.M.Y. and Lam K.S.L., Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese. , European Journal of Endocrinology. 2010, 163: 251-257.

Ong K.L., Tso A.W.K., Lam K.S.L., Cherny S.S., Sham P.C. and Cheung B.M.Y., Using glycosylated hemoglobin to define the metabolic syndrome in United States adults, Diabetes Care. 2010, 23: 1856-8.

Poon T.Y., Ong K.L. and Cheung B.M.Y., Review of the Traditional Chinese Medicine formula, Rehmannia Six Formula, on diabetes mellitus and its complications, J Diabetes. 2011, Epub ahead of print.

Samaranayake N.R., Ong K.L., Leung Y.H. and Cheung B.M.Y., Pharmacological management of obesity in the national health and nutrition examination survey (NHANES) 2007-2008), Basic & Clinical Pharmacology & Toxicology. Presented at the 10th Congress of the European Association for Clinical Pharmacology and Therapeutics, Budapest. 2011, 109 (Suppl. 1): 138-139.

Researcher : Ong KL

List of Research Outputs

Cheung B.M.Y. and Ong K.L., The Challenge of Managing Hypertension. In: Finkel ML, ed., Public Health in the 21st Century. Santa Barbara, CA: Praeger Publishing. 2010.

Researcher : Pang R.W.C.

Project Title:	A study of the modulatory effects of p53 on Pin1-mediated tumor growth, invasion and metastasis in hepatocellular carcinoma
Investigator(s):	Pang RWC, Kwong YL, Tse EWC
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2008

Project Title:	Study of a novel role of Pin1 in regulating invasiveness and metastasis of hepatocellular carcinoma via Rho signaling
Investigator(s):	Pang RWC, Kwong YL, Tse EWC
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010

List of Research Outputs

Zhang W..., Wang J..., Zou B..., Sardet C..., Li J..., Lam S...C..., Ng L..., Pang R...W...C..., Hung I...F...N..., Tan V...P...Y..., Jiang B... and Wong B...C...Y..., Four and a half LIM protein 2 (FHL2) negatively regulates the transcription of E-cadherin through interaction with Snail1, European Journal of Cancer. 2011, 47(1): 121-130.

Zhang W..., Yang Y..., Jiang B..., Peng J., Tu S..., Sardet C..., Zhang Y..., Pang R...W...C..., Hung I...F...N..., Tan V...P...Y..., Lam S...C..., Wang J... and Wong B...C...Y..., XIAP-associated factor 1 interacts with and attenuates the trans-activity of four and a half LIM protein 2, Molecular Carcinogenesis. 2010, 50: 199-207.

Researcher : Pang RWC

Project Title:	A study of the modulatory effects of p53 on Pin1-mediated tumor growth, invasion and metastasis in hepatocellular carcinoma
Investigator(s):	Pang RWC, Kwong YL, Tse EWC
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2008

Project Title:	Study of a novel role of Pin1 in regulating invasiveness and metastasis of hepatocellular carcinoma via Rho signaling
Investigator(s):	Pang RWC, Kwong YL, Tse EWC
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010

List of Research Outputs

Chen W.J., Chow A.K., Ng L., Poon R.T.P., Wong B.C.Y. and Pang R.W.C., Identification of CD44+ Cancer Cells in Gastric Cancer by Chemotherapeutic Enrichment, Submitted. 2010.

Chow A.K., Cheng N.M., Ng L., Chu A.C.Y., Poon R.T.P. and Pang R.W.C., Anti-tumor Efficacy of Human Recombinant Arginase in Combination with Chemotherapeutic Agents in Human Hepatocellular Carcinoma, Submitted. 2010.

Chow A.K., Poon R.T.P., Ng L., Chiu L., Cheng D., Ng R.L. and Pang R.W.C., Identification and Characterization of Cancer Initiating Cells in Pleural Effusions of Liver Cancer Patients., Submitted. 2010.

Chow K.M., Chu A.C.Y., Poon R.T.P., Wong B.C.Y. and Pang R.W.C., Blockade of Raf/MEK/ERK Pathway by Raf265 Inhibits Tumor Growth Via in Colorectal Cancer , 17th Hong Kong International Cancer Congress. 2010.

Chu A.C.Y., Lam S.C., Poon R.T.P. and Pang R.W.C., Enhanced Therapeutic Efficacy Of Transarterial Chemoebolization Treatment In Hcc By Mtor Inhibitor Rad001, 16th Medical Research Conference, Department Of Medicine, The University Of Hong Kong. 2011.

Chu A.C.Y., Lam S.C., Chow K.M., Poon R.T.P. and Pang R.W.C., RAD001 inhibits the growth of HCC in TACE treated orthotropic HCC models , 17th Hong Kong International cancer congress. 2010.

Ma J., Wang J., Zhang W., Zou B., Chen W., Lam S.C., Chen M., Pang R.W.C., Tan V.P.Y., Hung I.F.N., Lan H.Y., Wang Q. and Wong B.C.Y., Promoter hypermethylation and histone hypoacetylation contribute to Pancreatic-duodenal homeobox 1 (PDX1) silencing in gastric cancer., Carcinogenesis. 2010, 31(9): 1552-60.

Pang R.W.C., Metastatic Cancer Cells: An Opportunity for Improving Target Treatment? , The Hong Kong Society of Flow Cytometry Stem Cell Seminar. 2010.

Yau T., Pang R.W.C., Chan P. and Poon R.T.P., Molecular targeted therapy of advanced hepatocellular carcinoma beyond sorafenib., Expert Opin Pharmacother. 2010, 13: 2187-2198.

Yau T.C.C., Chan P., Cheung F.Y., Lee A.S., Yau T.K., Choo S.P., Toh H.C., Leung A.K., Wong J.S., Wong S., Lau J., Pang R.W.C., Fan S.T. and Poon R.T.P., Efficacy and tolerability of Sorafenib, Capecitabine and Oxaliplatin (Secox) in patients with advanced hepatocellular carcinoma: a multi-centre phase II study (Abstract), The 7th International Meeting Hepatocellular Carcinoma Eastern and Western Experiences, Paris, France, 14-15 January 2011.

Yau T.C.C., Chan P., Pang R.W.C., Ng K.K.C., Fan S.T. and Poon R.T.P., Phase 1-2 trial of PTK787/ZK222584 combined with intravenous doxorubicin for treatment of patients with advanced hepatocellular carcinoma: implication for antiangiogenic approach to hepatocellular carcinoma, Cancer. 2010, 116(21): 5022-5029.

Zhang W., Jiang B., Guo Z., Sardet C., Zou B., Lam S.C., Li J., He M., Lan H.Y., Pang R.W.C., Hung I.F.N., Tan V.P.Y., Wang J. and Wong B.C.Y., Four-and-a-half LIM protein 2 promotes invasive potential and epithelial-mesenchymal transition in colon cancer., Carcinogenesis. 2010, 31: 1220-9.

Zou B., Chim J.C.S., Pang R.W.C., Zeng H.U.I., Dai Y., Zhang R., Lam S.C., Tan V.P.Y., Hung I.F.N. and Lan H.Y., XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification, Mol Carcinog. 2011.

Zou B., Chim J.C.S., Pang R.W.C., Zeng H.U.I., Dai Y., Zhang R., Lam S.C., Tan V.P.Y., Hung I.F.N., Lan H.Y. and Wong B.C.Y., XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification, Molecular Carcinogenesis. 2010, under review.

Researcher : Qiuwaxi J

List of Research Outputs

Mok T.M.Y., Yiu K.H., Wong C.Y., Qiuwaxi J., Lai W.H.K., Wong R.W.S., Tse H.F. and Lau W.C.S., Low circulating level of CD133+KDR+cells in patients with systemic sclerosis., Clinical and Experimental Rheumatology. 2010, 28(5 Suppl 62): S19-25.

Researcher : Ramsden DB

List of Research Outputs

Chan K.H., Kwan S.C., Ho W.L., Ho W.M. and Ramsden D.B., Aquaporin-4 autoantibodies in neuromyelitis optica spectrum disorders: comparison between tissue-based and cell-based indirect immunofluorescence assays, 15th Research Postgraduate Symposium, LKS Faculty of Medicine, the University of Hong Kong. 2010.

Chan K.H., Kwan S.C., Ho W.L., Ho W.M., Chu A.C.Y. and Ramsden D.B., Aquaporin-4 autoantibodies in neuromyelitis optica spectrum disorders: comparison between tissue-based and cell-based indirect immunofluorescence assays, Journal of Neuroinflammation. 2010, 7(1): 50.

Ho W.L., Ho W.M., Liu H., So H.F., Chan K.H., Ramsden D.B. and Ho S.L., Functional studies of neuronal mitochondrial uncoupling proteins: implication in the pathology of Parkinson’s disease, The Hong Kong Neurological Society - Annual Scientific Meeting 2010; Kowloon Shangri-La Hotel, Hong Kong; 2010.. 2010.

Ho W.L., Ho W.M., So H.F., Liu H., Chan K.H., Ramsden D.B. and Ho S.L., Manipulation of mitochondria functions via uncoupling proteins as novel strategy against energy deficiency and neurodegeneration, Croucher Advanced Study Institute on Mitochondrial Stress in Diabetes and Aging, 29 April, 2011, organized by the Croucher Foundation; HBHA, University of Hong Kong.. 2011.

Ho W.L., Ho W.M., So H.F., Liu H., Chan K.H., Ramsden D.B. and Ho S.L., Potential role of mitochondrial uncoupling protein-4 (UCP4) in energy supply during neuronal differentiation , 16th Medical Research Conference 2011, University of Hong Kong. 2011, 17(1): suppl 1;: 31.

Ho W.L., Ho W.M., Zhang W., Yiu C.W., Liu H., Chan K.H., Ramsden D.B. and Ho S.L., Role of mitochondrial uncoupling protein-4 (UCP4) in energy supply during neuronal differentiation, EMBO Meeting 2010, Barcelona, Spain. 2010.

Ho W.M., Ho W.L., Zhang W., Liu H., Kwok H.H., Yiu C.W., Chan K.H., Kung M.H.W., Ramsden D.B. and Ho S.L., Activation of c-Rel mediates neuroprotection via mitochondrial uncoupling protein-4 under NF-kB pathways, EMBO Meeting 2010, Barcelona, Spain (4-7 Sept, 2010). 2010.

Researcher : Samaranayake NR

List of Research Outputs

Samaranayake N.R., Ong K.L., Leung Y.H. and Cheung B.M.Y., Pharmacological management of obesity in the national health and nutrition examination survey (NHANES) 2007-2008), Basic & Clinical Pharmacology & Toxicology. Presented at the 10th Congress of the European Association for Clinical Pharmacology and Therapeutics, Budapest. 2011, 109 (Suppl. 1): 138-139.

Samaranayake N.R., Cheung S.T.D., Chui C.M.W. and Cheung B.M.Y., Reducing the use of inappropriate abbreviations in prescriptions, Presented at the 6th International symposium on healthy ageing of the Research Centre of Heart, Brain, Hormone & Healthy Aging, The University of Hong Kong. 2011.

Samaranayake N.R., Cheung S.T.D. and Chui C.M.W., Reducing the use of inappropriate abbreviations in prescriptionsReducing the use of inappropriate abbreviations in prescriptions, Presented at the 6th International symposium on healthy ageing, Hong Kong. 2011.

Researcher : Sang Y

List of Research Outputs

Sang Y., Su H., Yang X., Liu L.G., Wu W. and Cheung R.T.F., Neural stem cell transplantation in a rat model of intracerebral haemorrhage plus haematoma aspiration, Sixteenth Medical Research Conference. 2011, 17 (Suppl 1): 51.

Researcher : Shen J

Project Title:	Biochemical Society Meeting 679 University of Essex UK - Stress, Signalling and Control Reactive Oxygen Species Mediate Intracellular Cholesterol Accumulation via Modulating Caveolin-1 Pathway in Chinese Hamster Ovary Cells
Investigator(s):	Shen J
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	07/2003

Project Title:	Interactions of Reactive Nitrogen Species, Caveolins and Matrix Metalloproteinases: A Novel Signal Mechanism in Disruption of Blood Brain Barrier during Ischemic Stroke
Investigator(s):	Shen J, Chung SK, So KF, Yang D
Department:	School of Chinese Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2008

Project Title:	Elucidating Effects and Mechanisms of Isoflavonoids from Astragalus Mongholicus in Improving Neurogenesis for Post-stroke Treatment
Investigator(s):	Shen J, Fu S
Department:	School of Chinese Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	01/2010
Completion Date:	12/2010

Project Title:	Development of Hydroxysafflor Yellow A (HSYA) as a Botanical Drug for Reducing Blood Brain Barrier Permeability and Preventing Infarction Enlargement in Stroke Treatment
Investigator(s):	Shen J
Department:	School of Chinese Medicine
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2010
Completion Date:	06/2011

Project Title:	Elucidating caveolin-1 as a negative modulating protein for proliferation of neural stem/progenitor cells and neural differentiation in post-ischemic brain
Investigator(s):	Shen J, Chung SK, So KF
Department:	School of Chinese Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2010

Project Title:	7th World Stroke Congress Interaction of caveolin-1, nitric oxide and matrix metalloproteinases impacts on blood brain barrier disruption and infarction enlargement in cerebral ischemia-reperfusion injury
Investigator(s):	Shen J
Department:	School of Chinese Medicine
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	10/2010
Completion Date:	10/2010

Project Title:	Effects of reactive nitrogen species inhibitors on preventing thrombolysis-induced blood brain barrier disruption and hemorrhagic transformation in cerebral ischemia-reperfusion injury
Investigator(s):	Shen J, Yang D, Liu KJ
Department:	School of Chinese Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2011

Researcher : Shiu SWM

List of Research Outputs

Tam H.L., Shiu S.W.M., Leng L., Bucala R., Betteridge D.J. and Tan K.C.B., Enhanced expression of receptor for advanced glycation end-products is associated with low circulating soluble isoforms of the receptor in Type 2 diabetes, Clin Sci (Lond). 2011, 120(2): 81-9.

Tan K.C.B., Wang Y., Shiu S.W.M., Wong Y., Yung S.S.Y. and Chan D.T.M., Adenosine triphosphate binding cassette transporter G1-mediated cholesterol efflux to serum is impaired in type 2 diabetes mellitus, American Diabetes Association 71st Scientific Sessions, San Diego, USA. San Diego, USA, 2011.

Tan K.C.B., Shiu S.W.M., Wong Y. and Tam H.L., Serum advanced glycation end products is associated with insulin resistance independent of adiponectin, 46thEuropean Association for the Study of Diabetes Annual Meeting, Stockholm, Sweden. 2010.

Researcher : Siu DCW

Project Title:	Dynamic Conformational Changes of the P-S6 linker of the Pacemaker (HCN) Channels Identified by Sulfhydryl Modification: Pore-to-Gate Coupling Model
Investigator(s):	Siu DCW, Tse HF
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	10/2008

Project Title:	Long-term Efficacy and Safety of a Gene-based Bio-artificial Pacemaker tested in a large animal Sick Sinus Syndrome Model
Investigator(s):	Siu DCW, Lau CP, Li RA, Tse HF
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2009

Project Title:	Cardiac hypertrophic signals for cardiac differentiation of embryonic stem cells
Investigator(s):	Siu DCW
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	08/2009

Project Title:	Driven Maturation of Embryonic Stem Cell-Derived Cardiomyocytes via Cardiac Hypertrophic Signals
Investigator(s):	Siu DCW, Tse HF
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2010

Project Title:	Supraventricular ectopic activity for prediction of atrial fibrillation and ischemic stroke
Investigator(s):	Siu DCW
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	09/2010

List of Research Outputs

Chan H.T., So J., Li S.W., Siu D.C.W., Lau C.P. and Tse H.F., J Cardiovasc Pharmacol, Effect of herbal consumption on clinical efficacy of warfarin therapy in patients with atrial fibrillation. 2011.

Chan Y.C., Tse H.F. and Siu D.C.W., A Newly-derived Small Synthetic Compound Alleviated Ventricular Fibrillation In A Pig Model With Chronic Myocardial Infarction As Revealed By Optical Mapping., 16th Medical Research Conference (15th MRC) (Hong Kong, 2011), Department of Medicine, HKU. 2011.

Chan Y.C., Tse H.F. and Siu D.C.W., A Newly-derived Small Synthetic Compound Alleviated Ventricular Fibrillation In A Pig Model With Chronic Myocardial Infarction As Revealed By Optical Mapping., Sixth International Symposium on Healthy Aging (Hong Kong, 2011), Department of Medicine, HKU . 2011.

Chan Y.H., Siu D.C.W., Li L.S.W., Lam T.H., Lau C.P. and Tse H.F., Abnormal Vascular Function In Pr Interval Prolongation: Novel Insights Into Mechanisms Of Adverse Cardiovascular Outcomes (Abstract and Oral Presentation), 3rd Asian Preventive Cardiology & Cardiac Rehabilitation Conference cum 8th Certificate Course in Cardiac Rehabilitation, 11-14 December 2010, Hong Kong. Hong Kong, Hong Kong College of Cardiology, 2010.

Chan Y.H., Lam T.H., Lau K.K., Yiu K.H., Siu D.C.W., Li S.W., Chan H.T., Tam S., Lau C.P. and Tse H.F., Dietary Intake of Phytoestrogen is Associated with Increased Circulating Endothelial Progenitor Cells in Patients with Cardiovascular Disease, European Journal of Cardiovascular Prevention and Rehabilitation. 2010.

Chan Y.H., Lam T.H., Lau G.K.K., Yiu K.H., Siu D.C.W., Li L.S.W., Chan K.H.T., Tam S., Lau C.P. and Tse H.F., Dietary intake of phytoestrogen is associated with increased circulating endothelial progenitor cells in patients with cardiovascular disease, European Journal of Cardiovascular Prevention and Rehabilitation. 2011, 18(3): 360-368.

Ho H.H., Lau T.W., Leung F.K.L., Tse H.F. and Siu D.C.W., Peri-operative management of anti-platelet agents and anti-thrombotic agents in geriatric patients undergoing semi-urgent hip fracture surgery. , Osteoporosis International 2010 Dec;21(Suppl 4):S573-7. Epub 2010 Nov 6. 2010.

Ho J.C.Y., Zhou T., Lai K.W.H., Huang Y., Chan Y.C., Li X., Wong L.Y. .N., Li Y., Au K.W., Guo D., Xu J., Siu D.C.W., Pei D., Tse H.F. and Esteban M.A., Generation of induced pluripotent stem cell lines from 3 distinct laminopathies bearing heterogeneous mutations in lamin A/C., Aging (Albany NY). 2011, 3(4): 380-90.

Ho L.Y., Siu D.C.W., Yue W., Lau C.P., Lip G.Y. and Tse H.F., Safety and efficacy of oral anticoagulation therapy in Chinese patients with concomitant atrial fibrillation and hypertension, Journal of Human Hypertension. 2010, Epub.

Lau T.W., Leung F.K.L., Siu D.C.W., Wong G.T.C. and Luk K.D.K., Geriatric hip fracture clinical pathway: the Hong Kong experience. , Osteoporosis International. 2010 Dec;21(Suppl 4):S573-7. Epub 2010 Nov 6. 2010.

Lau T.W., Leung F.K.L., Siu D.C.W., Wong G.T.C. and Luk K.D.K., Geriatric hip fracture clinical pathway: the Hong Kong experience, Osteoporosis International. 2010, 21(S4): S627-S636.

Lau Y.F., Yiu K.H., Siu D.C.W. and Tse H.F., J Hum Hypertens, Hypertension and atrial fibrillation: Epidemiology, pathophysiology and therapeutic implications. 2011.

Lee Y.K., Ng K.M., Lai K.W.H., Chan Y.C., Lau Y.M., Lian Q., Tse H.F. and Siu D.C.W., Calcium Homeostasis in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes., Stem Cell Reviews and Reports. 2011.

Liao S., Liu Y., Siu D.C.W., Zhang Y., Lai K.W.H., Au K.W., Lee Y.K., Li R.A. and Tse H.F., Proarrhythmic risk of embryonic stem cell-derived cardiomyocyte transplantation in infarcted myocardium, Heart Rhythm. 2010, 7(12): 1852-9.

Lo I.L., Siu D.C.W., Tse H.F., Lau T.W., Leung F.K.L. and Wong M., Lo IL, Siu CW, Tse HF, Lau TW, Leung F, Wong M: Pre-operative pulmonary assessment for patients with hip fracture, Osteoporos International 2010 Dec;21(Suppl 4):S579-86. Epub 2010 Nov 6. 2010.

Ng K.M., Chan Y.C., Lee Y.K., Lai W.H., Au K.W., Fung M.L., Siu D.C.W., Li R.A. and Tse H.F., Cobalt Chloride Pretreatment Promotes Cardiac Differentiation of Human Embryonic Stem Cells under atmospheric oxygen level. x, Cell Reprogramming. In press.. 2011.

Ng K.M., Chan Y.C., Lee Y.K., Lai W.H., Fung M.L., Siu D.C.W., Li R.A. and Tse H.F., Cobalt chloride pre-treatment enhances the calcium handling of human embryonic stem cells-derived cardiomyocytes, Differentiation, 80:S44 Suppl. 1, 2010.

Ng K.M., Lee Y.K., Lai K.W.H., Chan Y.C., Fung M.L., Tse H.F. and Siu D.C.W., Exogenous Expression of Human apoA-I Enhances Cardiac Differentiation of Pluripotent Stem Cells., PLoS One. 2011.

Siu D.C.W., Jim M.H., Lau C.P. and Tse H.F., Acute Cardiac Care, Thromborprophylaxis in patients with acute atrial fibrillation. 2011.

Siu D.C.W., Distinguished Research Paper Award for Young Investigators 2010 , The Hong Kong College of Physcians. 2010.

Siu D.C.W., Yiu K.H., Lee K.L.F., Yan G., Lee S.W.L., Lau C.P. and Tse H.F., Effects of Right Low Atrial Septal versus Right Atrial Appendage Pacing on Atrial Mechanical Function and Dyssynchrony in Patients with Sinus Node Dysfunction and Paroxysmal Atrial Fibrillation, European Journal of Echocardiography. 2010, 11: 672.

Siu D.C.W., Yan G., Yue W., Lee K.L.F., Lee S.W.L., Lau C.P. and Tse H.F., Effects of right low atrial septal versus right atrial appendage pacing on atrial mechanical function and dyssynchrony in patients with sinus node dysfunction and paroxysmal atrial fibrillation , Heart Rhythm. 2011.

Siu D.C.W., Yiu K.H., Yan G., Yue W., Lee K.L.F., Lee S.W.L., Lau C.P. and Tse H.F., Effects of right low atrial septal versus right atrial appendage pacing on atrial mechanical function and dyssynchrony in patients with sinus node dysfunction and paroxysmal atrial fibrillation, European Society of Echocardiogram. 2010.

Siu D.C.W., Lee K.L.F., Yue W., Yan G., Lee S.W.L., Lau C.P. and Tse H.F., Effects of right low atrial septal versus right atrial appendage pacing on strial mechanical function and dyssynchrony in patients with sinus node dysfunction and paroxysmal atrial fibrillation. , Heart Rhythm. 2011.

Siu D.C.W. and Tse H.F., Europace, A shock in time saves ablation?. 2011, 133: 155-156.

Siu D.C.W., Late Breaking Basic Science Abstract, European Society of Cardiology Annual Scientific Meeting , European Society of Cardiology. 2010.

Siu D.C.W., Sun N.C.H., Lau T.W., Yiu K.H., Leung F.K.L. and Tse H.F., Siu CW, Sun NC, Lau TW, Yiu KH, Leung F, Tse HF: Preoperative cardiac risk assessment in geriatric patients with hip fractures: an orthopedic surgeons' perspective. , Osteoporos Int. 2010 Dec;21(Suppl 4):S529-34. Epub 2010 Nov 6. 2010.

Siu D.C.W., Liao S., Liu Y., Lian Q. and Tse H.F., Stem cells for myocardial repair, Thrombosis and Hemostasis. 2010, 104(1): 6-12.

Wang M.M., Siu D.C.W., Yan G., Yue W., Lee K.L.F., Lee S.W.L., Lau C.P. and Tse H.F., Effects of right low atrial septal versus right atrial appendage pacing on atrial mechanical function and dyssynchrony in patients with sinus node dysfunction and paroxysmal atrial fibrillation , Heart Rhythm. 2011.

Wang M.M., Yan G., Yue W., Siu D.C.W., Yiu K.H., Lee S.W.L. and Tse H.F., Left ventricular mechanical dyssynchrony predicts exercise capacity in patients with coronary artery disease and narrow QRS duration, Journal of The American Society of Echocardiography. 2011.

Yan G., Wang M.M., Yue W., Luk T.H., Dai Y.L.E., Siu D.C.W., Yiu K.H., Lee S.W.L. and Tse H.F., Coenzyme Q10 Supplementation Improves Left Ventricular Torsion In Patients With Ischemic Cardiomyopathy, AHA. 2010.

Yiu K.H., Pong V., Siu D.C.W., Lau C.P. and Tse H.F., Cardiovasc Diabetol, Long-term oral nitrate therpy is assoicated with adverse outcome in diabetic patients after elective percutaneous coronary intervention.. 2011, 10(1): 52.

Yiu K.H., Zhang X.H., Tse H.F. and Siu D.C.W., Left ventricular apical akinetic aneurysmatic area associated with permanent right ventricular apical pacing for advanced atrioventricular block: clinical characteristics and long-term outcome. , Europace. . 2011, 13: 514-9.

Yiu Y.F., Chan Y.H., Yiu K.H., Siu D.C.W., Chan H.T., Li S.W., Wong L.Y., Tam S., Lau C.P. and Tse H.F., Vitamin D Deficiency Is Associated With Depletion Of Circulating Endothelial Progenitor Cells And Endothelial Dysfunction In Patients With Type II Diabetes, European Society of Cardiology Annual Congress 2010. European Heart Journal (Supp) 2010 P4690, 2010 . 2010.

Yiu Y.F., Chan Y.H., Yiu K.H., Siu D.C.W., Li L.S.W., Wong L.Y., Lee S.W.L., Tam S., Wong E.W.K., Cheung B.M.Y. and Tse H.F., Vitamin D deficiency is associated with depletion of circulating endothelial progenitor cells and endothelial dysfunction in patients with type 2 diabetes. , J Clin Endocrinol Metab. 2011, 96(5): E830-835.

Yue W., Chong B.H., Zhang X., Liao S., Jim M.H., Kung A.W.C., Tse H.F. and Siu D.C.W., Hyperthyroidism-induced left ventricular diastolic dysfunction: implication in hyperthyroidism-related heart failure, Clin Endocrinol (Oxf). 2011, 74(5): 636-43.

Yue W., Wang M.M., Yan G., Yiu K.H., Yin L.X., Lee S.W.L., Siu D.C.W. and Tse H.F., Smoking is associated with depletion of circulating endothelial progenitor cells and elevated pulmonary artery pressure in patients with coronary artery disease , American Journal of Cardiology . 2010, 2010 Nov 1;106(9):1248-54.

Zhang J., Chan Y.C., Ho J.C.Y., Siu D.C.W., Lian Q. and Tse H.F., Proliferation of Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells via Ether à go-go 1 (hEAG1) Potassium Channel., Journal of Cellular and Molecular Medicine (Under Review). 2011.

Researcher : So HF

List of Research Outputs

Ho W.L., Ho W.M., Liu H., So H.F., Chan K.H., Ramsden D.B. and Ho S.L., Functional studies of neuronal mitochondrial uncoupling proteins: implication in the pathology of Parkinson’s disease, The Hong Kong Neurological Society - Annual Scientific Meeting 2010; Kowloon Shangri-La Hotel, Hong Kong; 2010.. 2010.

Ho W.L., Ho W.M., So H.F., Liu H., Chan K.H., Ramsden D.B. and Ho S.L., Manipulation of mitochondria functions via uncoupling proteins as novel strategy against energy deficiency and neurodegeneration, Croucher Advanced Study Institute on Mitochondrial Stress in Diabetes and Aging, 29 April, 2011, organized by the Croucher Foundation; HBHA, University of Hong Kong.. 2011.

Ho W.L., Ho W.M., So H.F., Liu H., Chan K.H., Ramsden D.B. and Ho S.L., Potential role of mitochondrial uncoupling protein-4 (UCP4) in energy supply during neuronal differentiation , 16th Medical Research Conference 2011, University of Hong Kong. 2011, 17(1): suppl 1;: 31.

Researcher : Soong SS

List of Research Outputs

Bow C.H.Y., Leung E., Cheung C.L., Xiao S., Loong C., Soong S.S., Tan K.C.B., Luckey M.M., Cauley J.A., Fujiwara S. and Kung A.W.C., Ethnic Difference of Clinical Vertebral Fracture Risk, 12th Regional Osteoporosis Conference, Hong Kong. 2011.

Bow C.H.Y., Cheung E., Cheung C.L., Xiao S., Loong C., Soong S.S., Tan K.C.B., Luckey M.M., Cauley J.A., Fujiwara S. and Kung A.W.C., Ethnic difference of clinical vertebral fracture risk, Osteoporosis International. 2011.

Researcher : Sun H

List of Research Outputs

Liu H., Yang L., Jin M.W., Sun H., Huang Y. and Li G.R., The selective estrogen receptor modulator raloxifene inhibits cardiac delayed rectifier potassium currents and voltage-gated sodium current without QTc interval prolongation. , Pharmacol Res. 2010, 62(5): 384-390.

Tao R., Sun H., Lau C.P., Tse H.F., Lee H.C. and Li G.R., Cyclic ADP ribose is a novel regulator of intracellular Ca(2+) oscillations in human bone marrow mesenchymal stem cells. , J Cell Mol Med. 2011, 15(12): 2684-96.

Zhang X., Jin M., Sun H., Zhang S. and Li G.R., The calmodulin inhibitor N-(6-aminohexyl)-5-chloro-1-naphthalene sulphonamide directly blocks human ether à-go-go-related gene potassium channels stably expressed in human embryonic kidney 293 cells., Br J Pharmacol. 2010, 161(4): 872-884.

Zhang Y., Sun H., Tse H.F., Lau C.P. and Li G.R., Identification of transient receptor potential channels in human atrial myocytes, 16th Medical Research Conference, Department of Medicine, HKU. 2011, 17(1): 68.

Researcher : Tam HL

List of Research Outputs

Tam H.L., Shiu S.W.M., Leng L., Bucala R., Betteridge D.J. and Tan K.C.B., Enhanced expression of receptor for advanced glycation end-products is associated with low circulating soluble isoforms of the receptor in Type 2 diabetes, Clin Sci (Lond). 2011, 120(2): 81-9.

Tan K.C.B., Shiu S.W.M., Wong Y. and Tam H.L., Serum advanced glycation end products is associated with insulin resistance independent of adiponectin, 46thEuropean Association for the Study of Diabetes Annual Meeting, Stockholm, Sweden. 2010.

Researcher : Tam S

List of Research Outputs

Chan Y.H., Lam T.H., Lau G.K.K., Yiu K.H., Siu D.C.W., Li L.S.W., Chan K.H.T., Tam S., Lau C.P. and Tse H.F., Dietary intake of phytoestrogen is associated with increased circulating endothelial progenitor cells in patients with cardiovascular disease, European Journal of Cardiovascular Prevention and Rehabilitation. 2011, 18(3): 360-368.

Cheung B.M.Y., Ong K.L., Jiang C.Q., Liu B., Jin Y.L., Tso A.W.K., Tam S., Wong K.S., Tomlinson B., Lin J.M., Yue X.J., Lam K.S.L., Lam T.H. and Thomas G.N., Association of a genetic variant in the apolipoprotein A5 gene with the metabolic syndrome in Chinese, Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Chu L.W., Tam S., Wong L.C., Yik P.Y., Song Y., Cheung B.M.Y., Morley J.E. and Lam K.S.L., Bioavailable Testosterone Predicts a Lower Risk of Alzheimer's Disease in Older Men, J Alzheimers Dis. 2010, 21(4): 1335-1345.

Yiu Y.F., Chan Y.H., Yiu K.H., Siu D.C.W., Li L.S.W., Wong L.Y., Lee S.W.L., Tam S., Wong E.W.K., Cheung B.M.Y. and Tse H.F., Vitamin D deficiency is associated with depletion of circulating endothelial progenitor cells and endothelial dysfunction in patients with type 2 diabetes. , J Clin Endocrinol Metab. 2011, 96(5): E830-835.

Researcher : Tan KCB

Project Title:	Lectin-like oxidized low-density-lipoprotein receptor-1 in diabetes
Investigator(s):	Tan KCB
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	12/2008
Completion Date:	11/2010

Project Title:	Soluble receptor for advanced glycation end products and diabetic complications
Investigator(s):	Tan KCB
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2008
Completion Date:	11/2010

Project Title:	MircoRNA and reverse cholesterol transport
Investigator(s):	Tan KCB
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	12/2009
Completion Date:	11/2011

Project Title:	Reverse cholesterol transport and diabetic nephropathy
Investigator(s):	Tan KCB, Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010

Project Title:	Carbamylated LDL and diabetes
Investigator(s):	Tan KCB
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	03/2011

List of Research Outputs

Bow C.H.Y., Leung E., Cheung C.L., Xiao S., Loong C., Soong S.S., Tan K.C.B., Luckey M.M., Cauley J.A., Fujiwara S. and Kung A.W.C., Ethnic Difference of Clinical Vertebral Fracture Risk, 12th Regional Osteoporosis Conference, Hong Kong. 2011.

Bow C.H.Y., Cheung E., Cheung C.L., Xiao S., Loong C., Soong S.S., Tan K.C.B., Luckey M.M., Cauley J.A., Fujiwara S. and Kung A.W.C., Ethnic difference of clinical vertebral fracture risk, Osteoporosis International. 2011.

CHN L.O.O.N.G., Bow C.H.Y., Yeung S.C., Tan K.C.B. and Kung A.W.C., Bone Mineral Density in Patients with Spine Fracture Treated with Alendronate Sodium and Strontium Ranelate, 12th Regional Osteoporosis Conference, Hong Kong. 2011.

Colhoun H.M., Deshmukh H., Betteridge D.J., Durrington P., Fuller J.H., Hyde C., Livingstone S., Mckeigue P.M., Neil H.A., Charlton-Menys V., Bao W., DeMicco D.D., Preston G.M., Tan K.C.B. and Hitman G., Genome Wide Scan of soluble RAGE levels in a Diabetic Population reveals a novel associated variant in RAGE-HLA-DQA2 region, American Diabetes Association 71st Scientific Sessions, San Diego, USA. 2011.

Lam J.K., Lam C.W., Kung A.W.C., Tan K.C.B., Lau K.S. and Lam K.S.L., A man with hypophosphataemia, BMJ. 2011, 342:d773.

Lam J.K.Y., Lam K.S.L., Kung A.W.C., Tan K.C.B., Chow W.S. and Tso A.W.K., A woman with raised alkaline phosphatase and forearm deformity, BMJ. 2011, 342: d3435.

Lee C.H., Tai B.C., Lim G.H., Chan M.Y., Low A.F., Tan K.C.B., Chia B.L. and Tan H.C., Correlation between high density lipoprotein-cholesterol and remodeling index in patients with coronary artery disease: IDEAS (IVUS diagnostic evaluation of atherosclerosis in Singapore)-HDL study, Int J Cardiovasc Imaging. 2011, [Epub ahead of print].

Loong C.H.N., ELY L.E.U.N.G., Tan K.C.B. and Kung A.W.C., A Nurse-Led Clinic Reduced Osteoporosis Clinic Default Rate and Improved Drug-adherence Rate, 12th Regional Osteoporosis Conference, Hong Kong. 2011.

Tam H.L., Shiu S.W.M., Leng L., Bucala R., Betteridge D.J. and Tan K.C.B., Enhanced expression of receptor for advanced glycation end-products is associated with low circulating soluble isoforms of the receptor in Type 2 diabetes, Clin Sci (Lond). 2011, 120(2): 81-9.

Tan K.C.B., Wang Y., Shiu S.W.M., Wong Y., Yung S.S.Y. and Chan D.T.M., Adenosine triphosphate binding cassette transporter G1-mediated cholesterol efflux to serum is impaired in type 2 diabetes mellitus, American Diabetes Association 71st Scientific Sessions, San Diego, USA. San Diego, USA, 2011.

Tan K.C.B., Advanced glycation end products and atherosclerosis, 6th International Huaxia Congress of Endocrinology, Shanghai. 2010.

Tan K.C.B., Advances in management of diabetes mellitus, 1st AMM-AMS-HKAM Tripartite Congress/44th Malaysia-Singapore Congress of Medicine, Hong Kong. 2010.

Tan K.C.B., Beijing Baishideng BioMed Scientific Co. Ltd., World Journal of Diabetes. 2010.

Tan K.C.B., Bentham Science Publishers, The Open Diabetes Journal. 2010.

Tan K.C.B., Bentham Science Publishers, The Open Translational Medicine Journal. 2010.

Tan K.C.B., Co-Chairman of the Scientific Committee, 12th Hong Kong Diabetes and Cardiovascular Risk Factors - East Meets West Symposium, Hong Kong. 2010.

Tan K.C.B., Honorary Editorial Advisory Board Member, MIMS Endocrinology Guide. 2011.

Tan K.C.B., Journal of Diabetes Investigation, 2010.

Tan K.C.B., Lipids and advanced glycation end products in endothelial dysfunction in diabetes, Joint Congress of the Australian Atherosclerosis Society & Asian Pacific Society of Atherosclerosis and Vascular Diseases, Cairns, Australia. 2010.

Tan K.C.B., Member of International Advisory Committee, 8th International Diabetes Federation Western Pacific Region Congress, Busan, Korea.. 2010.

Tan K.C.B., Member of the Organising Committee, 6th Huaxia Congress of Endocrinology to be held in Shanghai. 2010.

Tan K.C.B., Novel treatment strategies in diabetes mellitus, Hong Kong College of Physicians Annual Scientific Meeting, Hong Kong. 2010.

Tan K.C.B., Quantitative and Qualitative Abnormalities of Lipid Metabolism in Diabetes, Hong Kong Society of Clinical Chemistry Annual Scientific Meeting, Hong Kong. 2011.

Tan K.C.B., Shiu S.W.M., Wong Y. and Tam H.L., Serum advanced glycation end products is associated with insulin resistance independent of adiponectin, 46thEuropean Association for the Study of Diabetes Annual Meeting, Stockholm, Sweden. 2010.

Tan K.C.B., Treating dyslipidemia with statins: the risk benefit profile among Asian populations, Asia Regional Cardiovascular-Metabolic Forum, Hong Kong. 2010.

Xiao S., Gao Y., Cheung C.L., Bow C.H.Y., Lau K.S., Sham P.C., Tan K.C.B. and Kung A.W.C., Association of Cdx1 Binding Site of Periostin Gene with Bone Mineral Density and Vertebral Fracture Risk, The 3rd Joint Meeting of the European Calcified Tissue Society and the International Bone and Mineral Society, 7-11 MAY, Athens, Greece. Athens, Greece, 2011, 7-11 MAY.

Researcher : Tan V.P.Y.

Project Title:	Prevalence of Fermentable Oligo-, Di- and Mono- saccharides and Polyols (FODMAPS) malabsorption in Chinese Control, Functional Dyspepsia, Irritable Bowel and Inflammatory Bowel Disease Patients
Investigator(s):	Tan VPY
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2011

List of Research Outputs

Zhang W..., Wang J..., Zou B..., Sardet C..., Li J..., Lam S...C..., Ng L..., Pang R...W...C..., Hung I...F...N..., Tan V...P...Y..., Jiang B... and Wong B...C...Y..., Four and a half LIM protein 2 (FHL2) negatively regulates the transcription of E-cadherin through interaction with Snail1, European Journal of Cancer. 2011, 47(1): 121-130.

Zhang W..., Yang Y..., Jiang B..., Peng J., Tu S..., Sardet C..., Zhang Y..., Pang R...W...C..., Hung I...F...N..., Tan V...P...Y..., Lam S...C..., Wang J... and Wong B...C...Y..., XIAP-associated factor 1 interacts with and attenuates the trans-activity of four and a half LIM protein 2, Molecular Carcinogenesis. 2010, 50: 199-207.

Researcher : Tan VPY

Project Title:	Prevalence of Fermentable Oligo-, Di- and Mono- saccharides and Polyols (FODMAPS) malabsorption in Chinese Control, Functional Dyspepsia, Irritable Bowel and Inflammatory Bowel Disease Patients
Investigator(s):	Tan VPY
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2011

List of Research Outputs

Lam P.K.Y., Ng M.L., Cheung T.K., Wong B.Y.H., Tan V.P.Y., Fong D.Y.T., Wei W.I. and Wong B.C.Y., Rabeprazole is effective in treating laryngopharyngeal reflux, In: C. Mel Wilcox, M.D., Clinical Gastroenterology and Hepatology. Elsevier, 2010, 8: 770-776.

Ma J., Wang J., Zhang W., Zou B., Chen W., Lam S.C., Chen M., Pang R.W.C., Tan V.P.Y., Hung I.F.N., Lan H.Y., Wang Q. and Wong B.C.Y., Promoter hypermethylation and histone hypoacetylation contribute to Pancreatic-duodenal homeobox 1 (PDX1) silencing in gastric cancer., Carcinogenesis. 2010, 31(9): 1552-60.

Tan V.P.Y. and Wong B.C.Y., Helicobacter pylori and gastritis: Untangling a complex relationship 27 years on., In: Geoff Farrell, Journal Of Gastroenterology And Hepatology. Wiley InterScience, 2011, Suppl 1: 42-5.

Tan V.P.Y. and Wong B.C.Y., One size does not fit all - time to regionalize Helicobacter pylori eradication?, In: Roy Pounder NJ Talley, Alimentary Pharmacology and Therapeutics. Wiley InterScience, 2010, 32(3): 506-7.

Tan V.P.Y. and Wong B.C.Y., Patients vote with their feet for 'On demand' rabeprazole in the maintenance treatment phase of reflux oesophagitis., In: Roy Pounder NJ Talley, Alimentary Pharmcology And Therapeutics Journal. Wiley InterScience, 2010, 32(2): 305-7.

Tan V.P.Y., Yan B.P., Hunt R.H. and Wong B.C.Y., Proton pump inhibitor and clopidogrel interaction: the case for watchful waiting., In: Geoff Farrell, Journal Of Gastroenterology And Hepatology. Wiley InterScience, 2010, 25(8): 1342-7.

Zhang W., Jiang B., Guo Z., Sardet C., Zou B., Lam S.C., Li J., He M., Lan H.Y., Pang R.W.C., Hung I.F.N., Tan V.P.Y., Wang J. and Wong B.C.Y., Four-and-a-half LIM protein 2 promotes invasive potential and epithelial-mesenchymal transition in colon cancer., Carcinogenesis. 2010, 31: 1220-9.

Zou B., Chim J.C.S., Pang R.W.C., Zeng H.U.I., Dai Y., Zhang R., Lam S.C., Tan V.P.Y., Hung I.F.N. and Lan H.Y., XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification, Mol Carcinog. 2011.

Zou B., Chim J.C.S., Pang R.W.C., Zeng H.U.I., Dai Y., Zhang R., Lam S.C., Tan V.P.Y., Hung I.F.N., Lan H.Y. and Wong B.C.Y., XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification, Molecular Carcinogenesis. 2010, under review.

Researcher : Tang CSO

List of Research Outputs

Ma M.K.M., Yung S.S.Y., Yim A.S.Y., Ng K.F., Tang C.S.O., Lui S.L. and Chan D.T.M., Low- versus conventional-level of glucose peritoneal dialysis regimes - comparison of inflammatory and fibrotic mediators in peritoneal dialysate, World Congress of Nephrology 2011.

Yap D.Y.H., Tang C.S.O., Yung S.S.Y., Choy C.B.Y., Yuen R.M.F. and Chan D.T.M., Long-term outcome of renal transplant recipients with chronic hepatitis B infection - impact of antiviral treatments, Transplantation. 2010, 90(3): 325-330.

Researcher : Tang CW

Project Title:	Mapping the molecular footprints and therapeutic targets of diabetic nephropathy
Investigator(s):	Tang SCW, Lan HY
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2008
Completion Date:	12/2010

Project Title:	Role of N-acetyl-seryl-aspartyl-lysyl-proline in nephropathies
Investigator(s):	Tang SCW, Lan HY
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2009

Project Title:	Genetic analysis in Chinese patients with nephropathy due to type 2 diabetes
Investigator(s):	Tang SCW, Leung JCK, Chu DWS
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2009
Completion Date:	02/2011

Project Title:	Role of bone morphogenetic protein-7 in diabetic nephropathy
Investigator(s):	Tang SCW
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010

Project Title:	Provision of free mycophenolate mofetil for IgA nephropathy patients with persistent proteinuria despite maximal angiotensin blockade therapy in Hong Kong
Investigator(s):	Tang SCW, Lai KN
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	08/2010

Project Title:	Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-label pilot study
Investigator(s):	Tang SCW, Lai KN
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	10/2010

Project Title:	ASN's 43rd Annual Meeting and Scientific Exposition Additive Renoprotective Effects of B2−Kinin Receptor Blocker and PPAR−g Agonist in Uninephrectomized db/db Mice Impact of Nephrotic Leg Edema on OSA: Gathering a Unifying Concept for the Pathogenetic Role of Nocturnal Rostral Fluid Shift
Investigator(s):	Tang SCW
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	11/2010
Completion Date:	11/2010

List of Research Outputs

Researcher : Tang SCW

Project Title:	Mapping the molecular footprints and therapeutic targets of diabetic nephropathy
Investigator(s):	Tang SCW, Lan HY
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2008
Completion Date:	12/2010

Project Title:	Role of N-acetyl-seryl-aspartyl-lysyl-proline in nephropathies
Investigator(s):	Tang SCW, Lan HY
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2009

Project Title:	Genetic analysis in Chinese patients with nephropathy due to type 2 diabetes
Investigator(s):	Tang SCW, Leung JCK, Chu DWS
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2009
Completion Date:	02/2011

Project Title:	Role of bone morphogenetic protein-7 in diabetic nephropathy
Investigator(s):	Tang SCW
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010

Project Title:	Provision of free mycophenolate mofetil for IgA nephropathy patients with persistent proteinuria despite maximal angiotensin blockade therapy in Hong Kong
Investigator(s):	Tang SCW, Lai KN
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	08/2010

Project Title:	Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-label pilot study
Investigator(s):	Tang SCW, Lai KN
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	10/2010

Project Title:	ASN's 43rd Annual Meeting and Scientific Exposition Additive Renoprotective Effects of B2−Kinin Receptor Blocker and PPAR−g Agonist in Uninephrectomized db/db Mice Impact of Nephrotic Leg Edema on OSA: Gathering a Unifying Concept for the Pathogenetic Role of Nocturnal Rostral Fluid Shift
Investigator(s):	Tang SCW
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	11/2010
Completion Date:	11/2010

List of Research Outputs

Au W.S., Chan G., Leung J.C.K., Chan L.Y., Lan H.Y., Lai K.N. and Tang S.C.W., Ac-SDKP reduces proinflammatory response in PTEC during pathogenic albumin load, J Am Soc Nephrol. 2010, 21: 279A.

Lai K.N., Chan L.Y., Guo H., Tang S.C.W. and Leung J.C.K., Additive effect of PPAR-γ agonist and ARB in treatment of experimental IgA nephropathy, Pediatric Nephrology. 2011, 26(2): 257-266.

Lai K.N., Lam M.F., Leung J.C.K., Chan L.Y. and Tang S.C.W., Clinical and biochemical profile of a low-glucose degradation product peritoneal dialysis fluid: a four-year study, J Am Soc Nephrol. 2010, 21: 307A.

Lai K.N. and Tang S.C.W., Diabetes and the Kidney, Edited by K.N. Lai and S.C.W. Tang, Publisher: S Karger AG, Basel, Switzerland. 2011.

Lai K.N., Leung J.C.K. and Tang S.C.W., The Renin-Angiotensin System, In: Diabetes and the Kidney, Edited by K.N. Lai and S.C. Tang, S Karger AG, Basel, Switzerland. 2011, 135-144.

Lai K.N., Leung J.C.K. and Tang S.C.W., The renin-angiotensin system, Contributions to Nephrology. 2011, 170: 135-44.

Leung J.C.K., Chan L.Y., Tang S.C.W. and Lai K.N., Glomerulotubular interaction in IgA nephropathy induces oxidative damages in tubular epithelial cells: role of crosstalk between angiotensin II and aldosterone. Proceedings of the World Congress of Nephrology April 2011, J Am Soc Nephrol. 2010.

Ma M.K., Yap D.Y. and Tang S.C.W., Transplant kidney herniation in an elderly patient, Nephrology. 2010.

Tang S.C.W., Chan Y.Y., Leung J.C.K., Cheng A.S., Lan H.Y. and Lai K.N., Additive Renoprotective Effects Of B2-kinin Receptor Blocker And PPAR-y Agonist In Uninephrectomized Db/db Mice [journal Impact Factor 4.602] (in Press), Lab Invest . 2011, 91(9): 1351-62.

Tang S.C.W., Chan L.Y., Leung J.C.K., Lan H.Y. and Lai K.N., Additive renoprotective effects of B2-kinin receptor blocker and PPAR-γ agonist in uninephrectomized db/db mice, J Am Soc Nephrol. 2010, 21: 692A.

Tang S.C.W., Lin M., Tam S., Au W.S., Ma K.M., Yap D.Y., Ho Y.W. and Lai K.N., Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-labeled pilot study. Proceedings of the World Congress of Nephrology April 2011, J Am Soc Nephrolol. 2010.

Tang S.C.W., Lin M., Tam S., Au W.S., Ma M.K., Yap D.Y., Ho Y.W. and Lai K.N., Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-labeled pilot study, Nephrology Dialysis Transplantation. 2011.

Tang S.C.W., Award of one PDF post with 50% Central funding and 25% funding from the RCII, 2010.

Tang S.C.W., Deputy Editor-in-Chief, Hong Kong Journal of Nephrology. Elsevier, 2011.

Tang S.C.W., Leung J.C.K. and Lai K.N., Diabetic Tubulopathy: an Emerging Entity, In: Diabetes and the Kidney, Edited by K.N. Lai and S.C. Tang, S Karger AG, Basel, Switzerland. 2011, 124-134.

Tang S.C.W., Diabetic nephropathy: a global and growing threat, Hong Kong Medical Journal. 2010.

Tang S.C.W., Leung J.C.K. and Lai K.N., Diabetic tubulopathy: an emerging entity, Contributions to Nephrolology. 2011, 170: 124-134.

Tang S.C.W., Chan Y.Y., Leung J.C.K., Cheng A.S., Lin M., Lan H.Y. and Lai K.N., Differential effects of advanced glycation end-products on renal tubular cell inflammation, Nephrology (Carlton, Vic). 2011, 16(4): 417-25.

Tang S.C.W., Direct renin inhibitor, a novel therapeutic approach for diabetic nephropathy, 12th Hong Kong Diabetes and Cardiovascular Risk Factors - East Meets West Symposium (Hong Kong, China). 2010.

Tang S.C.W., GRF Incentive Award 2010-11 (HKU 778910M), HK$ 25,000, 2010.

Tang S.C.W., Immunomodulatory treatment against IgA nephropathy, The 7th International Symposium on Tonsils and Mucosal Barriers of the Upper Airways (Asahikawa, Japan) . 2010.

Tang S.C.W., Immunomodulatory treatment for IgA nephropathy, The 8th Asia Transplantation Immunology Forum, Chinese Society of Transplantation, China Medical Association (CMA), and the Chinese Dialysis and Transplant Association (Suzhou, China) . Suzhou, China, 2010.

Tang S.C.W., Lam B., Lam J.C., Yap D.Y., Ip M.S.M. and Lai K.N., Impact of nephrotic leg edema on OSA: gathering a unifying concept for the pathogenetic role of nocturnal rostral fluid shift, J Am Soc Nephrol. 2010, 21: 417A.

Tang S.C.W., Lecture 1: Chronic hepatitis B in patients with renal diseases Lecture 2: Management of chronic hepatitis C in patients with renal diseases , Infectious Disease Conference 2011, Hospital Authority Infectious Disease Centre & The Hong Kong Society for Infectious Diseases. 2011.

Tang S.C.W., Managing Editor, Case Reports in Nephrology and Urology. KARGER, 2011.

Tang S.C.W., Pharmacologic treatment for IgA nephropathy, 54th Annual Meeting of the Japanese Society of Nephrology (Yokohama, Japan). 2011.

Tang S.C.W., Publication Award Department of Medicine for publication in Journal in the top 10% of the subspecialty, HK$ 10,000, 2010.

Tang S.C.W., Publication Award, Department of Medicine for publication in Journal in the top 10% of the subspecialty, HK$ 10,000Award of one PDF post with 50% Central funding (23rd Round PDF/RAP scheme) and 25% funding from the RCII , 2010.

Tang S.C.W., Publication Award, for publication in Journal in the top 10% of the subspecialty, HK$ 10,000, 2010.

Tang S.C.W., Leung J.C.K., Chan L.Y., Lan H.Y. and Lai K.N., Renoprotection by rosiglitazone in accelerated type 2 diabetic nephropathy: role of STAT1 inhibition and nephrin restoration, American Journal of Nephrology. 2010, 32: 145-155.

Tang S.C.W., Staff Incentive Award, Department of Medicine for fundable-but-not-funded GRF application (score 3.5), HK$ 50,000, 2010.

Tang S.C.W., Leung J.C.K. and Lai K.N., The Kallikrein-Kinin System, In: Diabetes and the Kidney, Edited by K.N. Lai and S.C. Tang, S Karger AG, Basel, Switzerland. 2011, 145-155.

Tang S.C.W., Leung V.T.M., Chan Y.Y., Wong S.S., Chu D.W., Leung J.C.K., Ho Y.W., Lai K.N., Ma L., Elbein S.C., Bowden D.W., Hicks P.J., Comeau M.E., Langefeld C.D. and Freedman B.I., The acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with nephropathy in Chinese patients with type 2 diabetes, Nephrology Dialysis Transplantation. 2010, 25(12): 3931-4.

Tang S.C.W., Leung J.C.K. and Lai K.N., The kallikrein-kinin system, Contributions to Nephrology. 2011, 170: 145-155.

Yap D.Y., Chu F.S.K., Chu S.S.M., Tam P.C., Tam S., Chan D.T.M., Lai K.N. and Tang S.C.W., CT angiography versus conventional digital angiography in preoperative assessment for Chinese living kidney donors, Journal of Nephrology. 2010, 23(6): 711-6.

Yap D.Y., Hwang G.Y., Lam J.K. and Tang S.C.W., Gas in the renal shadow of a plain abdominal X ray- emphysematous pyelonephritis, Nephrology. 2010.

Yap D.Y., Leung C.C., Hwang Y.Y., Leung A.Y., Chan G.S., Chan K.W. and Tang S.C.W., Pyrexia of unknown origin and proteinuria- an enigma solved by renal biopsy, Nephrology. 2010.

Yap D.Y., Tso W.K., Chu F.S., Chan D.T.M., Lai K.N. and Tang S.C.W., Transhepatic placement of hemodialysis catheter : a solution for vascular access exhaustion, Nephrology. 2010, 15(6): 661-2.

Yip T.P.S., Tse K.C., Ng F.S.K., Hung I.F.N., Lam M.F., Tang S.C.W., Lui S.L., Lai K.N., Chan D.T.M. and Lo W.K., Clinical course and outcomes of single-organism Enterococcus peritonitis in dialysis patients, Peritoneal Dialysis International. 2011, 31.

Researcher : Tang VWK

List of Research Outputs

Chan P., Wong H., Yao T.J., Tang V.W.K., Wong H., Fan S.T., Poon R.T.P. and Yau T.C.C., The outcomes of elderly patients with advanced hepatocellular carcinoma treated with single agent Sorafenib (Abstract), The 7th International Meeting Hepatocellular Carcinoma Eastern and Western Experiences, Paris, France, 14-15 January 2011.

Researcher : Tao R

List of Research Outputs

Tao R., Sun H., Lau C.P., Tse H.F., Lee H.C. and Li G.R., Cyclic ADP ribose is a novel regulator of intracellular Ca(2+) oscillations in human bone marrow mesenchymal stem cells. , J Cell Mol Med. 2011, 15(12): 2684-96.

Tao R., Lee H.C. and Li G.R., Cyclic ADP ribose is a novel regulator of intracellular Ca2+ oscillations in human bone marrow mesenchymal stem cells, New Horizons in Calcium Signaling. Oct, 2010. Beijing, China. 2010, p173.

Zhang Y., Tao R. and Li G., Both ion channels and calcium signals regulate proliferation in human adult mesenchymal stem cells from bone marrow, ISSCR 9th Annual Meeting. June 2011. Metro Toronto Convention Centre, TORONTO, Canada. 2011, 156.

Researcher : Tse EWC

Project Title:	Identification and characterization of Pin1 binding proteins
Investigator(s):	Tse EWC
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	01/2010

Project Title:	Outstanding Young Researcher Award 2009-10
Investigator(s):	Tse EWC
Department:	Medicine
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	12/2010

Project Title:	Pin1 modulates the functions of HIF-1 alpha in cancer cells
Investigator(s):	Tse EWC
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	01/2011

List of Research Outputs

Chan T.S., Au W.Y., Lam K., Lam Y.F., So J.C.C., Leung A.Y.H., Tse E.W.C., Lie A.K.W. and Kwong Y.L., Donor cell leukaemia after allogeneic haematopoietic SCT followed by prolonged thalidomide maintenance for multiple myeloma, Bone Marrow Transplant. 2011, [Epub ahead of print].

Gill H., Chim J.C.S., Au W.Y., Loong F., Tse E.W.C., Leung A.Y.H. and Kwong Y.L., Non-gastric marginal zone B cell lymphoma: clinicopathologic features and treatment results, Ann Hematol. 2011, [Epub ahead of print].

Lam B., Wong M.K.Y., Lu K.H., Au W.Y., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Liang R.H.S., Lam W.K., Ip M.S.M. and Lie A.K.W., Effects of Azithromycin in bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation – a randomized double-blinded placebo-controlled study, Bone Marrow Transplantation. 2011, Epub ahead of print.

Lam C.L.D., Lam B., Wong M.K.Y., Lu K.H., Au W.Y., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Liang R.H.S., Lam W.K., Ip M.S.M. and Lie A.K.W., Effects of Azithromycin in bronchiolitis obliterans syndrome after hematopoietic SCT-a randomized double-blinded placebo-controlled study, Bone marrow transplantation. 2011, Epub ahead of print.

Tse E.W.C., Outstanding Young Researcher Award 2010, The University of Hong Kong. 2011.

Tse E.W.C., So J.C.C., Cheung W.W.W. and Kwong Y.L., T-cell prolymphocytic leukaemia: spontaneous immunophenotypical switch from CD4 to CD8 expression, Ann Hematol. 2010, 90(4): 479-81.

Researcher : Tse HF

Project Title:	Direct intramyocardial implantation of autologous bone marrow cells for enhancement of neovascularization in patients with "End-Staged" coronary artery disease
Investigator(s):	Tse HF, Lau CP, Kwong YL
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2004

Project Title:	Outstanding Researcher Award 2007-2008
Investigator(s):	Tse HF
Department:	Medicine
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	10/2008

Project Title:	Direct endomyocardial injection of autologous bone marrow cells for treatment of patients with "end-stage" ischaemic heart failure
Investigator(s):	Tse HF, Lau CP, Kwong YL, Siu DCW, Lee SWL, Chan FHW, Lam L, Lee KLF, Chan WS, Lam YM
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2009

Project Title:	Transplantation of Bioengineered Human Embryonic Stem Cell-derived Cardiomyocytes with Mature Electrical Phenotype in Post-infarction Heart Failure Improves Cardiac Function Without Proarrhythmia
Investigator(s):	Tse HF, Lau CP, Siu DCW, Wu EX
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2009
Completion Date:	12/2010

Project Title:	Relationship between mitochondrial dysfunction and vascular function in patients with cardiovascular diseases
Investigator(s):	Tse HF
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	01/2010
Completion Date:	12/2010

Project Title:	Pluripotent Human Stem Cell Platform for Tissue Regeneration and Drug Screening for Cardiovascular Diseases
Investigator(s):	Tse HF, Li RA, Siu DCW, Li GR, Lian Q
Department:	Medicine
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	03/2010

Project Title:	Autologous Induced Pluripotent Stem Cells Derived Cardiomyocytes for Cardiac Repair in Porcine Ischemic Cardiomyopathy
Investigator(s):	Tse HF, Li RA, Siu DCW
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2010

List of Research Outputs

Chan H.T., So J., Li S.W., Siu D.C.W., Lau C.P. and Tse H.F., J Cardiovasc Pharmacol, Effect of herbal consumption on clinical efficacy of warfarin therapy in patients with atrial fibrillation. 2011.

Chan Y.C., Tse H.F. and Siu D.C.W., A Newly-derived Small Synthetic Compound Alleviated Ventricular Fibrillation In A Pig Model With Chronic Myocardial Infarction As Revealed By Optical Mapping., 16th Medical Research Conference (15th MRC) (Hong Kong, 2011), Department of Medicine, HKU. 2011.

Chan Y.C., Tse H.F. and Siu D.C.W., A Newly-derived Small Synthetic Compound Alleviated Ventricular Fibrillation In A Pig Model With Chronic Myocardial Infarction As Revealed By Optical Mapping., Sixth International Symposium on Healthy Aging (Hong Kong, 2011), Department of Medicine, HKU . 2011.

Chan Y.H., Siu D.C.W., Li L.S.W., Lam T.H., Lau C.P. and Tse H.F., Abnormal Vascular Function In Pr Interval Prolongation: Novel Insights Into Mechanisms Of Adverse Cardiovascular Outcomes (Abstract and Oral Presentation), 3rd Asian Preventive Cardiology & Cardiac Rehabilitation Conference cum 8th Certificate Course in Cardiac Rehabilitation, 11-14 December 2010, Hong Kong. Hong Kong, Hong Kong College of Cardiology, 2010.

Chan Y.H., Lam T.H., Lau K.K., Yiu K.H., Siu D.C.W., Li S.W., Chan H.T., Tam S., Lau C.P. and Tse H.F., Dietary Intake of Phytoestrogen is Associated with Increased Circulating Endothelial Progenitor Cells in Patients with Cardiovascular Disease, European Journal of Cardiovascular Prevention and Rehabilitation. 2010.

Chan Y.H., Lam T.H., Lau G.K.K., Yiu K.H., Siu D.C.W., Li L.S.W., Chan K.H.T., Tam S., Lau C.P. and Tse H.F., Dietary intake of phytoestrogen is associated with increased circulating endothelial progenitor cells in patients with cardiovascular disease, European Journal of Cardiovascular Prevention and Rehabilitation. 2011, 18(3): 360-368.

Chen H., Yang B., Ju W., Zhang F., Hou X., Chen C., Zhai L., Wang J., Cao K., Chen M. and Tse H.F., Cir J, Long term clinical implication of the occurrence of dissociated pulmonary vein activities after circumferential left atrial ablation in patients with paroxysmal atrial fibrillation. 2011, 75: 73-9.

Chen M., Yang B., Chen H., Ju W., Zhang F. and Tse H.F., J Cardiovasc Electrophysiol, Randomized comparison between pulmonary vein antral isolation versus complex fractionated electogram ablation for paroxysmal atrial fibrillation. 2011.

Chung N., Jeon H.K., Lien L.M., Tse H.F., Chung W.S., Lee T.H. and Chen S.A., Thromb Haemost, Safety of edoxaban, an oral factor Xa inhibitor, in Asian patients with non-valvular atrial fibrillation.. 2011, 105: 535-44.

Ho H.H., Lau T.W., Leung F.K.L., Tse H.F. and Siu D.C.W., Peri-operative management of anti-platelet agents and anti-thrombotic agents in geriatric patients undergoing semi-urgent hip fracture surgery. , Osteoporosis International 2010 Dec;21(Suppl 4):S573-7. Epub 2010 Nov 6. 2010.

Ho J.C.Y., Zhou T., Lai K.W.H., Huang Y., Chan Y.C., Li X., Wong L.Y. .N., Li Y., Au K.W., Guo D., Xu J., Siu D.C.W., Pei D., Tse H.F. and Esteban M.A., Generation of induced pluripotent stem cell lines from 3 distinct laminopathies bearing heterogeneous mutations in lamin A/C., Aging (Albany NY). 2011, 3(4): 380-90.

Ho L.Y., Siu D.C.W., Yue W., Lau C.P., Lip G.Y. and Tse H.F., Safety and efficacy of oral anticoagulation therapy in Chinese patients with concomitant atrial fibrillation and hypertension, Journal of Human Hypertension. 2010, Epub.

Lau C.P. and Tse H.F., The importance of pacing site to prevent heart failure and atrial fibrillation in CRT/bradycardia, The 4th Qianjiang International Cardiovascular Conference, China.. 2010.

Lau C.P. and Tse H.F., The importance of pacing site to prevent heart failure and atrial fibrillation in CRT/bradycardia, The 4th Qianjiang International Cardiovascular Conference, China. 2010.

Lau Y.F., Yiu K.H., Siu D.C.W. and Tse H.F., J Hum Hypertens, Hypertension and atrial fibrillation: Epidemiology, pathophysiology and therapeutic implications. 2011.

Lee Y.K., Ng K.M., Lai K.W.H., Chan Y.C., Lau Y.M., Lian Q., Tse H.F. and Siu D.C.W., Calcium Homeostasis in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes., Stem Cell Reviews and Reports. 2011.

Li M., Ho J.C.Y., Lai K.W.H., Au K.W., Xu A., Cheung B.M.Y., Lam K.S.L. and Tse H.F., Hypoadiponectinemia and its Impact on circulating endothelial progenitor cells in patients with type 2 diabetes - adiponectin and endothelial progenitor cells, Diabetes/Metab Res Rev. 2010, 27: 185-94.

Li M., Ho J.C.Y., Lai K.W.H., Au K.W., Xu A., Cheung B.M.Y., Lam K.S.L. and Tse H.F., The decrement in circulating endothelial progenitor cells (EPCs) in type 2 diabetes is independent of the severity of the hypoadiponectemia, Diabetes Metab Res Rev. 2011, 27(2): 185-194.

Li X., Tse H.F., Yiu K.H., Li L.S.W. and Jin L.J., Effect of periodontal treatment on circulating CD34⁺ cells and peripheral vascular endothelial function: a randomized controlled trial, Journal of Clinical Periodontology. 2011, 38: 148-156.

Li X., Tse H.F. and Jin L.J., J Dent Res, An update on periodontal infections, endothelial dysfunction and circulating endothelial progenitor cells. 2011.

Liao S., Liu Y., Siu D.C.W., Zhang Y., Lai K.W.H., Au K.W., Lee Y.K., Li R.A. and Tse H.F., Proarrhythmic risk of embryonic stem cell-derived cardiomyocyte transplantation in infarcted myocardium, Heart Rhythm. 2010, 7(12): 1852-9.

Lip G.Y., Halperin J.L. and Tse H.F., Chest, The new 2010 European Society of Cardiology guidelines on atrial fibrillation management - an evolution or revolution?. 2011, 139: 738-41.

Lip G.Y., Tse H.F. and Lane D.A., Lancet, Management of atrial fibrillation. 2011.

Liu J., Song E., Xu A., Berger T., Mak T., Tse H.F., Law I., Huang B., Liang Y., Vanhoutte P. and Wang Y., Br J Pharmacol, Lipocalin-2 deficiency prevents endothelial dysfunction assoicated with dietary obesity: role of cytochrome P450 2C inhibition. 2011.

Lo I.L., Siu D.C.W., Tse H.F., Lau T.W., Leung F.K.L. and Wong M., Lo IL, Siu CW, Tse HF, Lau TW, Leung F, Wong M: Pre-operative pulmonary assessment for patients with hip fracture, Osteoporos International 2010 Dec;21(Suppl 4):S579-86. Epub 2010 Nov 6. 2010.

Mok T.M.Y., Yiu K.H., Wong C.Y., Qiuwaxi J., Lai W.H.K., Wong R.W.S., Tse H.F. and Lau W.C.S., Low circulating level of CD133+KDR+cells in patients with systemic sclerosis., Clinical and Experimental Rheumatology. 2010, 28(5 Suppl 62): S19-25.

Ng K.M., Chan Y.C., Lee Y.K., Lai W.H., Au K.W., Fung M.L., Siu D.C.W., Li R.A. and Tse H.F., Cobalt Chloride Pretreatment Promotes Cardiac Differentiation of Human Embryonic Stem Cells under atmospheric oxygen level. x, Cell Reprogramming. In press.. 2011.

Ng K.M., Chan Y.C., Lee Y.K., Lai W.H., Fung M.L., Siu D.C.W., Li R.A. and Tse H.F., Cobalt chloride pre-treatment enhances the calcium handling of human embryonic stem cells-derived cardiomyocytes, Differentiation, 80:S44 Suppl. 1, 2010.

Ng K.M., Lee Y.K., Lai K.W.H., Chan Y.C., Fung M.L., Tse H.F. and Siu D.C.W., Exogenous Expression of Human apoA-I Enhances Cardiac Differentiation of Pluripotent Stem Cells., PLoS One. 2011.

Ong K.L., Li M., Tso A.W.K., Xu A., Cherny S.S., Sham P.C., Tse H.F., Lam T.H., Cheung B.M.Y. and Lam K.S.L., Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese. , European Journal of Endocrinology. 2010, 163: 251-257.

Siu D.C.W., Jim M.H., Lau C.P. and Tse H.F., Acute Cardiac Care, Thromborprophylaxis in patients with acute atrial fibrillation. 2011.

Siu D.C.W., Yiu K.H., Lee K.L.F., Yan G., Lee S.W.L., Lau C.P. and Tse H.F., Effects of Right Low Atrial Septal versus Right Atrial Appendage Pacing on Atrial Mechanical Function and Dyssynchrony in Patients with Sinus Node Dysfunction and Paroxysmal Atrial Fibrillation, European Journal of Echocardiography. 2010, 11: 672.

Siu D.C.W., Yan G., Yue W., Lee K.L.F., Lee S.W.L., Lau C.P. and Tse H.F., Effects of right low atrial septal versus right atrial appendage pacing on atrial mechanical function and dyssynchrony in patients with sinus node dysfunction and paroxysmal atrial fibrillation , Heart Rhythm. 2011.

Siu D.C.W., Yiu K.H., Yan G., Yue W., Lee K.L.F., Lee S.W.L., Lau C.P. and Tse H.F., Effects of right low atrial septal versus right atrial appendage pacing on atrial mechanical function and dyssynchrony in patients with sinus node dysfunction and paroxysmal atrial fibrillation, European Society of Echocardiogram. 2010.

Siu D.C.W., Lee K.L.F., Yue W., Yan G., Lee S.W.L., Lau C.P. and Tse H.F., Effects of right low atrial septal versus right atrial appendage pacing on strial mechanical function and dyssynchrony in patients with sinus node dysfunction and paroxysmal atrial fibrillation. , Heart Rhythm. 2011.

Siu D.C.W. and Tse H.F., Europace, A shock in time saves ablation?. 2011, 133: 155-156.

Siu D.C.W., Sun N.C.H., Lau T.W., Yiu K.H., Leung F.K.L. and Tse H.F., Siu CW, Sun NC, Lau TW, Yiu KH, Leung F, Tse HF: Preoperative cardiac risk assessment in geriatric patients with hip fractures: an orthopedic surgeons' perspective. , Osteoporos Int. 2010 Dec;21(Suppl 4):S529-34. Epub 2010 Nov 6. 2010.

Siu D.C.W., Liao S., Liu Y., Lian Q. and Tse H.F., Stem cells for myocardial repair, Thrombosis and Hemostasis. 2010, 104(1): 6-12.

Tao R., Sun H., Lau C.P., Tse H.F., Lee H.C. and Li G.R., Cyclic ADP ribose is a novel regulator of intracellular Ca(2+) oscillations in human bone marrow mesenchymal stem cells. , J Cell Mol Med. 2011, 15(12): 2684-96.

Tse H.F., "Novel Insight from Gene & Stem Cell Platform for Cadiac Arrhythmias", Visiting Professor, University of Minnesota, USA. 2011.

Tse H.F., Associate Editor, Journal of Cardiovascular Translational Research, 2011.

Tse H.F., Astra Zeneca - Public Talk " Women's heart health". 2011.

Tse H.F., Atrial Fibrillation: Medications or Catheter Ablation, The 21st Great Wall International Congress of Cardiology, Beijing, China. 2010.

Tse H.F., Chairman, "Memories and Future"from Pursuit of the Mechanisms of Cardiac Arrhythmais, "Basic Research for VT/VF and Stem Cell Therapy Speaker," PV Septal Pacing for Bradycadia," Gene and Cell Therapy for Cardiac Arrhythmias, The 3rd Pacific Heart Rhythm Society Scientific Session. 2011.

Tse H.F., Controlling AF: Rate versus Rhythm Control, Global Thrombosis Forum 2011 Barcelona Spain. 2011.

Tse H.F., Dean's Translational Science Lecture Series ,"New Era of Regenerative Medicine for Cardiovascular Diseases", Visiting Professor, USC KECK School of Medicine, University of Southern California, USA. 2011.

Tse H.F., Guest Editor, Review Series on “Stem Cells for Drug Screening” in Journal of Cardiovascular Pharmacology, 2011.

Tse H.F., HKU Press Conference " Breakthroughs in Stem Cell Research New Hopes for Treating Human Diseases". 2011.

Tse H.F., HKU Scientists Bring New Hopes to Translate Human Stem Cell Technologies to the Clinic, HKU Public Talk. 2011.

Tse H.F., Starfix Implantation: Tips & Tricks, Bi-annual Scientific Meeting in Xiamen, China. 2011.

Tse H.F., Stem Cell Therpy for angiogenesis and arrhythmia, 13th South China International Congress of Cardiology (SCC), 2011, China. 2011.

Tse H.F., The Effectivesness of Non-contact Mapping in Patients with complex arrhythmias, Invited Speaker,The 5th Oriental Congress of Cardiology Shanghai, China. 2011.

Tso A.W.K., Lam T.K.Y., Xu A., Yiu K.H., Tse H.F., Li L.S.W., Law S.C., Cheung B.M.Y., Cheung R.T.F. and Lam K.S.L., Serum adipocyte fatty acid-binding protein is associated with ischemic stroke and early death, Neurology. 2011, 76(23): 1968-75.

Wang M.M., Siu D.C.W., Yan G., Yue W., Lee K.L.F., Lee S.W.L., Lau C.P. and Tse H.F., Effects of right low atrial septal versus right atrial appendage pacing on atrial mechanical function and dyssynchrony in patients with sinus node dysfunction and paroxysmal atrial fibrillation , Heart Rhythm. 2011.

Wang M.M., Yan G., Yue W., Siu D.C.W., Yiu K.H., Lee S.W.L. and Tse H.F., Left ventricular mechanical dyssynchrony predicts exercise capacity in patients with coronary artery disease and narrow QRS duration, Journal of The American Society of Echocardiography. 2011.

Wang X.M., Li W., Fan W.X., Chan Y.C., Zhang S.Q., Guo X.P., Zhang Y., Chen S., Zhang Y.L., Schambach A., Tse H.F., Pei D.Q. and Esteban M.A., Modeling Abnormal Early Development with Induced Pluripotent Stem Cells from Aneuploid Syndromes., Human Molecular Genetics (Under Review). 2011.

Wu W., Lau C.P., Tse H.F. and Li G.R., Beta1 subunit-dependent modulation of BK channel by membrane cholesterol, J HK Coll Cardiol. 2010. 18(2): 65.

Wu W., Lau C.P., Tse H.F. and Li G.R., Effects of increased cholesterol level on BK channels, 16th Medical Research Conference, Department of Medicine, HKU. 2011, 17(1): 61.

Yan G., Wang M.M., Yue W., Luk T.H., Dai Y.L.E., Siu D.C.W., Yiu K.H., Lee S.W.L. and Tse H.F., Coenzyme Q10 Supplementation Improves Left Ventricular Torsion In Patients With Ischemic Cardiomyopathy, AHA. 2010.

Yang B., Xu A., Vanhoutte P.M.G.R., Tse H.F. and Wang Y., Lipocalin-2 Deficiency Protects Hearts Against Ischemia/Reperfusion Injury, Journal of the Hong Kong College of Cardiology, Fourteenth Annual Scientific Meeting, Institute of Cardiovascular Science and Medicine, 18 December 2010. 18:2: 66.

Yiu K.H., Pong V., Siu D.C.W., Lau C.P. and Tse H.F., Cardiovasc Diabetol, Long-term oral nitrate therpy is assoicated with adverse outcome in diabetic patients after elective percutaneous coronary intervention.. 2011, 10(1): 52.

Yiu K.H., Yeung C.K., Chan K.H.T., Wong R.M.Y., Tam S., Lam K.F., Yan G., Yue W., Chan H.H.L. and Tse H.F., Increased arterial stiffness in patients with psoriasis is associated with active systemic inflammation, British Journal of Dermatology. British Association of Dermatologists, 2011, 164: 514-520.

Yiu K.H., Wang S., Mok T.M.Y., Ooi G.C., Khing P.L., Lau C.S. and Tse H.F., J Rheumatol, Relationship between cardiac valvular and arterial calcification in patients with rheumatoid arthritis and systemic lupus erythematosus. 2011, 38: 621-7.

Yiu K.H., Zhang X.H., Tse H.F. and Siu D.C.W., Left ventricular apical akinetic aneurysmatic area associated with permanent right ventricular apical pacing for advanced atrioventricular block: clinical characteristics and long-term outcome. , Europace. . 2011, 13: 514-9.

Yiu K.H., Tse H.F., Mok T.M.Y. and Lau C.S., Nat Rev Rheumatol, Ethnic difference in the cardiovascular risk in patients with rheumatic disease: Focus on Asians. 2011, In Press.

Yiu K.H., Cheung B.M.Y. and Tse H.F., Pharmacological treatment for systolic heart failure. In Lip GY, Tse HF, Oxford: Oxford Univeristy Press. 2011.

Yiu K.H., Wang S., Mok T.M.Y., Ooi C.G.C., Khong P.L., Lau C.S. and Tse H.F., Relationship between cardiac valvular and arterial calcification in patients with rheumatoid arthritis and systemic lupus erythermatosus, Journal of Rheumatology . 2011, 38: 621-627.

Yiu K.H., Wang M.M. and Tse H.F., Stree echocardiography evaluation after percutaneous coronary intervention. In Tintoiu I, Rivard A, P:inte F, Gabriel C, Regar E (eds): , Coronary Stent Restenosis 2011 (in press). 2011.

Yiu Y.F., Chan Y.H., Yiu K.H., Siu D.C.W., Chan H.T., Li S.W., Wong L.Y., Tam S., Lau C.P. and Tse H.F., Vitamin D Deficiency Is Associated With Depletion Of Circulating Endothelial Progenitor Cells And Endothelial Dysfunction In Patients With Type II Diabetes, European Society of Cardiology Annual Congress 2010. European Heart Journal (Supp) 2010 P4690, 2010 . 2010.

Yiu Y.F., Chan Y.H., Yiu K.H., Siu D.C.W., Li L.S.W., Wong L.Y., Lee S.W.L., Tam S., Wong E.W.K., Cheung B.M.Y. and Tse H.F., Vitamin D deficiency is associated with depletion of circulating endothelial progenitor cells and endothelial dysfunction in patients with type 2 diabetes. , J Clin Endocrinol Metab. 2011, 96(5): E830-835.

Yue W., Chong B.H., Zhang X., Liao S., Jim M.H., Kung A.W.C., Tse H.F. and Siu D.C.W., Hyperthyroidism-induced left ventricular diastolic dysfunction: implication in hyperthyroidism-related heart failure, Clin Endocrinol (Oxf). 2011, 74(5): 636-43.

Yue W., Wang M.M., Yan G., Yiu K.H., Yin L.X., Lee S.W.L., Siu D.C.W. and Tse H.F., Smoking is associated with depletion of circulating endothelial progenitor cells and elevated pulmonary artery pressure in patients with coronary artery disease , American Journal of Cardiology . 2010, 2010 Nov 1;106(9):1248-54.

Zhang J., Chan Y.C., Ho J.C.Y., Siu D.C.W., Lian Q. and Tse H.F., Proliferation of Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells via Ether à go-go 1 (hEAG1) Potassium Channel., Journal of Cellular and Molecular Medicine (Under Review). 2011.

Zhang Y., Lau C.P., Tse H.F. and Li G.R., Expression of TrpC and TrpM channels in human atrial myocytes, J HK Coll Cardiol. 2010. 18(2): 71.

Zhang Y., Sun H., Tse H.F., Lau C.P. and Li G.R., Identification of transient receptor potential channels in human atrial myocytes, 16th Medical Research Conference, Department of Medicine, HKU. 2011, 17(1): 68.

Zhou T., Benda C., Duzinger S., Huang Y., Li X., Li Y., Guo X., Cao G., Chen S., Hao L., Chan Y.C., Ng K.M., Ho J.C.Y., Wieser M., Wu J., Redl H., Tse H.F., Grillari J., Grillari-Voglauer R., Pei D. and Esteban M.A., Generation of induced pluripotent stem cells from urine., Journal of the American Society of Nephrology. 2011.

Researcher : Tso AWK

Project Title:	A population-based prospective study to investigate the associations of obesity and adipokines with the incidence of cardiovascular disease and cancer
Investigator(s):	Tso AWK, Cheung BMY, Lam KSL, Lam TH, Lo SV, Tse HF, Wat NMS
Department:	Medicine
Source(s) of Funding:	Health and Health Services Research Fund - Full Grants
Start Date:	12/2008

Project Title:	Adipocyte fatty acid-binding protein – an adipocytokine with a role in diabetic nephropathy ?
Investigator(s):	Tso AWK, Lam KSL, Chan DTM, Xu A
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2009

Project Title:	The 6th Scientific Meeting of Asia-Pacific Diabets and Obesity Study Group Adipocyte fatty acid binding protein as a link between obesity and cardiovascular diseases
Investigator(s):	Tso AWK
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	08/2010
Completion Date:	08/2010

List of Research Outputs

Chen C., Tso A.W.K., Cheung B.M.Y., Ong K.L., Wat N.M.S., Edward D J.A.N.U.S., Xu A. and Lam K.S.L., Circulating Pigment Epithelium-Derived Factor Levels and the Risk of Hypertension in a Community-based Study., 16th Medical Research Conference, The University of Hong Kong. 2011.

Chen C., Tso A.W.K., Law S.C., Cheung B.M.Y., Ong K.L., Wat N.M.S., Janus E.D., Xu A. and Lam K.S.L., Plasma Level of Pigment Epithelium-Derived Factor Is Independently Associated with the Development of the Metabolic Syndrome in Chinese Men: A 10-Year Prospective Study. , J Clin Endocrinol Metab.. 2010, 95: 5074-81.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Association of a genetic variant in adrenomedullin gene with its plasma level , Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Cheung B.M.Y., Ong K.L., Jiang C.Q., Liu B., Jin Y.L., Tso A.W.K., Tam S., Wong K.S., Tomlinson B., Lin J.M., Yue X.J., Lam K.S.L., Lam T.H. and Thomas G.N., Association of a genetic variant in the apolipoprotein A5 gene with the metabolic syndrome in Chinese, Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Gamma-glutamyl transaminase level predicts the development of hypertension., Poster Presentation at the 23rd Scientific Meeting of the International Society of Hypertension, Vancouver. 2010.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Gamma-glutamyl transferase level predicts the development of hypertension in Hong Kong Chinese, Clin Chim Acta. 2011, 412(15-16): 1326-1331.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Lam T.H. and Lam K.S.L., Increasing prevalence of hypertension and central obesity in the Hong Kong cardiovascular risk factor prevalence study, Basic & Clinical Pharmacology & Toxicology. Presented at the 10th Congress of the European Association for Clinical Pharmacology and Therapeutics, Budapest. 2011, 109 (Suppl. 1): 108.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Lam T.H. and Lam K.S.L., Increasing prevalence of hypertension in Hong Kong Cardiovascular Risk Factor Prevalence Study: Role of general and central obesity, Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Thomas G.N., Lam T.H. and Lam K.S.L., Mendelian randomisation analysis suggests that plasma interleukin-6 is raised in hypertension but does not cause its development, Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Plasma adrenomedullin level is related to plasma interleukin-6 and a polymorphism in the adrenomedullin gene, Basic & Clinical Pharmacology & Toxicology. Presented at the 10th Congress of the European Association for Clinical Pharmacology and Therapeutics, Budapest. 2011, 109 (Suppl. 1): 102-103.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Role of genetic variants in gene encoding lipocalin-2 in the development of elevated blood pressure, Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Lam K.S.L., Cherny S.S. and Sham P.C., Using glycosylated haemoglobin to define the metabolic syndrome in United States adults, Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Cheung B.M.Y., Ong K.L., Tso A.W.K., Lam K.S.L., Cherny S.S. and Sham P.C., Using glycosylated hemoglobin to define the metabolic syndrome in United States adults. , Oral Presentation at the 23rd Scientific Meeting of the International Society of Hypertension, Vancouver. 2010.

Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Ong K.L., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., Genetic variants associated with persistent central obesity and the metabolic syndrome in a 12-year longitudinal study, Euro J Endocrinol . 2011, 164: 381-8.

Lam J.K.Y., Lam K.S.L., Kung A.W.C., Tan K.C.B., Chow W.S. and Tso A.W.K., A woman with raised alkaline phosphatase and forearm deformity, BMJ. 2011, 342: d3435.

Law L.S.C., Tso A.W.K., Tam S., Wat N.M.S., Cheung B.M.Y. and Lam K.S.L., Haemoglobin A1c is superior to fasting glucose in predicting the incidence of diabetes over 8 years among Chinese, Diabetes Res Clin Pract. 2010, 91(2): e53-6.

Michele Y.U.E.N., Wing Sun C.H.O.W., Chen C., Ting Chung P.U.N., Law S.C., Tso A.W.K., Xu A. and Lam K.S.L., . Circulating Plasma Pigment Epithelium-Derived Factor (PEDF) Levels Are Associated with Insulin Resistance in Women with Estrogen Deficiency, 71th American Diabetes Association Scientific Sessions, San Diego, CA. 2011.

Mok T.M.Y., Lau W.C.S., Chiu S.S.H., Tso A.W.K., Lo Y. and Law S.C., Systemic sclerosis is an independent risk factor for increased coronary artery calcium deposition, Arthritis Rheum. 2011, 63(5): 1387-95.

Ong K.L., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Lam T.H., Cheung B.M.Y. and Lam K.S.L., A genetic variant in the gene encoding adrenomedullin predicts the development of dysglycemia over 6.4 years in Chinese, Clin Chim Acta. 2010, 412: 353-7.

Ong K.L., Cheung B.M.Y., Tso A.W.K., Leung Y.H., Cherny S.S., Sham P.C., Lam T.H. and Lam K.S.L., Association of a genetic variant in adrenomedullin gene with its plasma level., Oral Presentation at the Annual Scientific Meeting of the Hong Kong Society of Endocrinology, Metabolism and Reproduction, Hong Kong. 2010.

Ong K.L., Jiang C.Q., Liu B., Jin Y.L., Tso A.W.K., Tam S., Wong K.S., Tomlinson B., Cheung B.M.Y., Lin J.M., Yue X.J., Lam K.S.L., Lam T.H. and Thomas G.N., Association of a genetic variant in the apolipoprotein A5 gene with the metabolic syndrome in Chinese, Clin Endocrinol (Oxf). 2010, 74: 206-13.

Ong K.L., Li M., Tso A.W.K., Xu A., Cherny S.S., Sham P.C., Tse H.F., Lam T.H., Cheung B.M.Y. and Lam K.S.L., Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese. , European Journal of Endocrinology. 2010, 163: 251-257.

Ong K.L., Tso A.W.K., Lam K.S.L., Cherny S.S., Sham P.C. and Cheung B.M.Y., Using glycosylated hemoglobin to define the metabolic syndrome in United States adults, Diabetes Care. 2010, 23: 1856-8.

Tso A.W.K., Lam T.K.Y., Xu A., Yiu K.H., Tse H.F., Li L.S.W., Law S.C., Cheung B.M.Y., Cheung R.T.F. and Lam K.S.L., Serum adipocyte fatty acid-binding protein is associated with ischemic stroke and early death, Neurology. 2011, 76(23): 1968-75.

Researcher : Tso HW

List of Research Outputs

Xiao S., Cherny S.S., Li H.Y., Gao Y., Tso H.W., Lau K.S., Luk K.D.K., Sham P.C. and Kung A.W.C., Association Of Jag1 Gene And Its Variant Sequence With Bone Mineral Density And Osteoporotic Fractures: A Genome-wide Association Study And Follow-up Replication Studies, The HKSEMR Annual Scientific Meeting and Annual General Meeting, 21 November, Hong Kong. 2010.

Researcher : Tsoi TH

List of Research Outputs

Pang S.Y.Y., Lee C.N., Tsoi T.H., Yip K.K., Chan K.H., Kung M.H.W. and Ho S.L., Transient axonal glycoprotein-1 (TAG-1) polymorphism and its correlation with clinical features and prognosis in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), 63rd American Academy of Neurology Annual Meeting 2011, Honlolulu,Hawaii; Neurology. 2011, 76 (Suppl 4): A570.

Researcher : Wang AYM

Project Title:	An epidemiologic survey of vitamin D deficiency in Chinese patients with moderate to severe chronic kidney disease
Investigator(s):	Wang AYM, Kwan CW, Lai KN
Department:	Medicine
Source(s) of Funding:	Health and Health Services Research Fund - Full Grants
Start Date:	07/2008

Project Title:	Providing intravenous paricalcitol treatment to the sick and poor chronic hemodialysis patients with severe secondary hyperparathyroidism resistant to existing vitamin D analogs
Investigator(s):	Wang AYM
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	08/2010

List of Research Outputs

Huang W., Gu H., Li R., Lou T., Zhang J., Shi W., Ye Z., Zhou Y., Li C., Xiong S., Li L., Wu C., Leung J.C.K., Lam M.F., Lai K.N. and Wang A.Y.M., Association of -27T>C and its haplotype at the putative promoter for IgA-specific receptor gene with IgA nephropathy among the Chinese Han population, Nephrology Dialysis Transplantation. 2011, 26(8): 2537-44.

Researcher : Wang J

Project Title:	Characterization of the interaction between XAF1 and FHL2 in carcinogenesis and differentiation of gastrointestinal cancers
Investigator(s):	Wang J, Wong BCY
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2008

Project Title:	Elucidation of the role of Sp1 in maintaining the survival and renewal of colon cancer stem cells
Investigator(s):	Wang J, Wong BCY
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2009

Project Title:	Characterization of the role and mechanisms of FHL2 in promoting epithelial mesenchymal transition of colon cancer
Investigator(s):	Wang J, Wong BCY
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010
Completion Date:	09/2010

List of Research Outputs

Ma J., Wang J., Zhang W., Zou B., Chen W., Lam S.C., Chen M., Pang R.W.C., Tan V.P.Y., Hung I.F.N., Lan H.Y., Wang Q. and Wong B.C.Y., Promoter hypermethylation and histone hypoacetylation contribute to Pancreatic-duodenal homeobox 1 (PDX1) silencing in gastric cancer., Carcinogenesis. 2010, 31(9): 1552-60.

Zhang W., Jiang B., Guo Z., Sardet C., Zou B., Lam S.C., Li J., He M., Lan H.Y., Pang R.W.C., Hung I.F.N., Tan V.P.Y., Wang J. and Wong B.C.Y., Four-and-a-half LIM protein 2 promotes invasive potential and epithelial-mesenchymal transition in colon cancer., Carcinogenesis. 2010, 31: 1220-9.

Researcher : Wang J.

Project Title:	Characterization of the interaction between XAF1 and FHL2 in carcinogenesis and differentiation of gastrointestinal cancers
Investigator(s):	Wang J, Wong BCY
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2008

Project Title:	Elucidation of the role of Sp1 in maintaining the survival and renewal of colon cancer stem cells
Investigator(s):	Wang J, Wong BCY
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2009

Project Title:	Characterization of the role and mechanisms of FHL2 in promoting epithelial mesenchymal transition of colon cancer
Investigator(s):	Wang J, Wong BCY
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010
Completion Date:	09/2010

List of Research Outputs

Zhang W..., Wang J..., Zou B..., Sardet C..., Li J..., Lam S...C..., Ng L..., Pang R...W...C..., Hung I...F...N..., Tan V...P...Y..., Jiang B... and Wong B...C...Y..., Four and a half LIM protein 2 (FHL2) negatively regulates the transcription of E-cadherin through interaction with Snail1, European Journal of Cancer. 2011, 47(1): 121-130.

Zhang W..., Yang Y..., Jiang B..., Peng J., Tu S..., Sardet C..., Zhang Y..., Pang R...W...C..., Hung I...F...N..., Tan V...P...Y..., Lam S...C..., Wang J... and Wong B...C...Y..., XIAP-associated factor 1 interacts with and attenuates the trans-activity of four and a half LIM protein 2, Molecular Carcinogenesis. 2010, 50: 199-207.

Researcher : Wang MM

Project Title:	Atrial Mechanical Dyssynchrony and Function in Sinus Node Disease Patients With And Without Atrial Fibrillation: Impacts of Different Modes of Atrial and Ventricular Pacing
Investigator(s):	Wang MM, Lau CP, Tse HF
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2009

List of Research Outputs

Wang M.M., Effects of Right Low Atrial Septal versus Right Atrial Appendage Pacing on Atrial Mechanical Function and Dyssynchrony in Patients with Sinus Node Dysfunction and Paroxysmal Atrial Fibrillation , European Society of Echocardiography. 2010.

Wang M.M., Siu D.C.W., Yan G., Yue W., Lee K.L.F., Lee S.W.L., Lau C.P. and Tse H.F., Effects of right low atrial septal versus right atrial appendage pacing on atrial mechanical function and dyssynchrony in patients with sinus node dysfunction and paroxysmal atrial fibrillation , Heart Rhythm. 2011.

Wang M.M., Yan G., Yue W., Siu D.C.W., Yiu K.H., Lee S.W.L. and Tse H.F., Left ventricular mechanical dyssynchrony predicts exercise capacity in patients with coronary artery disease and narrow QRS duration, Journal of The American Society of Echocardiography. 2011.

Wang M.M., The importance of pacing site to prevent heart failure and atrial fibrillation in CRT/bradycardia (Lecture) , The 4th Qianjiang International Cardiovascular Conference, China. 2010.

Yan G., Wang M.M., Yue W., Luk T.H., Dai Y.L.E., Siu D.C.W., Yiu K.H., Lee S.W.L. and Tse H.F., Coenzyme Q10 Supplementation Improves Left Ventricular Torsion In Patients With Ischemic Cardiomyopathy, AHA. 2010.

Yiu K.H., Wang M.M. and Tse H.F., Stree echocardiography evaluation after percutaneous coronary intervention. In Tintoiu I, Rivard A, P:inte F, Gabriel C, Regar E (eds): , Coronary Stent Restenosis 2011 (in press). 2011.

Yue W., Wang M.M., Yan G., Yiu K.H., Yin L.X., Lee S.W.L., Siu D.C.W. and Tse H.F., Smoking is associated with depletion of circulating endothelial progenitor cells and elevated pulmonary artery pressure in patients with coronary artery disease , American Journal of Cardiology . 2010, 2010 Nov 1;106(9):1248-54.

Researcher : Wang S

List of Research Outputs

Yiu K.H., Wang S., Mok T.M.Y., Ooi G.C., Khing P.L., Lau C.S. and Tse H.F., J Rheumatol, Relationship between cardiac valvular and arterial calcification in patients with rheumatoid arthritis and systemic lupus erythematosus. 2011, 38: 621-7.

Researcher : Wang Y

List of Research Outputs

Chang J., Li Y., Huang Y., Lam K.S.L., Hoo R.L.C., Wong W.T., Cheng K.Y., Wang Y., Vanhoutte P.M.G.R. and Xu A., Adiponectin prevents diabetic premature senescence of endothelial progenitor cells and promotes endothelial repair by suppressing the p38 MAP kinase/p16INK4A signaling pathway, Diabetes. 2010, 59: 2949-59.

Cheng K.Y., Lam K.S.L., Wang Y., Zhu W., Hoo R.L.C. and Xu A., Transgenic over-expression of APPL1 improves high-fat diet-induced insulin resistance in liver and skeletal muscle., Sixth International Symposium on Healthy Aging: " A New Golden Age”. 2011.. 2011.

Cheng K.Y., Lam K.S.L., Wang Y., Zhu W. and Xu A., Ubiquitination Is Indispensible For The Insulin-sensitizing Activity Of The Adaptor Protein Appl1. 16th Medical Research Conference. , 16th Medical Research Conference 2011. The University of Hong Kong. 2011.

Cheng K.Y., Lam K.S.L., Chen B., Zhu W., Wang Y. and Xu A., 銜接蛋白質APPL1和APPL2對島素敏感性和葡萄糖代謝的陰陽調控 - 從分子機制到生理作用, 2011.

Li F.Y.L., Wang Y., Xiao Y., Lam K.S.L. and Xu A., Endothelial-specific Activation Of Amp-activated Protein Kinase Improves Impairment In Endothelial Repair In Type 1 Diabetic Mice, Sixth International Symposium on Healthy Aging: “A New Golden Age”. 2011.

Li F.Y.L., Wang Y., Lam K.S.L. and Xu A., Endothelium-specific activation of AMP-activated protein kinase alleviates diabetes-induced impairment in endothelial repair in mice, 16th Medical Research Conference. 2011.

Zhu W., Cheng K.Y., Chen B., Wang Y., Lam K.S.L. and Xu A., APPL2 inhibits insulin-stimulated glucose uptake through both Akt and its downstream target TBC1D1 in skeletal muscle, 16th Medical Research Conference. The University of Hong Kong, Hong Kong. . 2011.

Researcher : Wang Y

List of Research Outputs

Cheng K.Y., Lam K.S.L., Chen B., Zhu W., Wang Y. and Xu A., 銜接蛋白質APPL1和APPL2對島素敏感性和葡萄糖代謝的陰陽調控 - 從分子機制到生理作用, 2011.

Researcher : Wat NMS

List of Research Outputs

Chen C., Tso A.W.K., Cheung B.M.Y., Ong K.L., Wat N.M.S., Edward D J.A.N.U.S., Xu A. and Lam K.S.L., Circulating Pigment Epithelium-Derived Factor Levels and the Risk of Hypertension in a Community-based Study., 16th Medical Research Conference, The University of Hong Kong. 2011.

Chen C., Tso A.W.K., Law S.C., Cheung B.M.Y., Ong K.L., Wat N.M.S., Janus E.D., Xu A. and Lam K.S.L., Plasma Level of Pigment Epithelium-Derived Factor Is Independently Associated with the Development of the Metabolic Syndrome in Chinese Men: A 10-Year Prospective Study. , J Clin Endocrinol Metab.. 2010, 95: 5074-81.

Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Ong K.L., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., Genetic variants associated with persistent central obesity and the metabolic syndrome in a 12-year longitudinal study, Euro J Endocrinol . 2011, 164: 381-8.

Law L.S.C., Tso A.W.K., Tam S., Wat N.M.S., Cheung B.M.Y. and Lam K.S.L., Haemoglobin A1c is superior to fasting glucose in predicting the incidence of diabetes over 8 years among Chinese, Diabetes Res Clin Pract. 2010, 91(2): e53-6.

Researcher : Wong B.C.Y.

Project Title:	Effect of XAF1 gene on tumor growth in gastric and colon cancer
Investigator(s):	Wong BCY, Tu S
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2003

Project Title:	Role of Bcl-2 family proteins in non-steroidal anti-inflammatory drug-induced apoptosis of gastric cancer
Investigator(s):	Wong BCY, Xia HHX
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004

List of Research Outputs

Zhang W..., Wang J..., Zou B..., Sardet C..., Li J..., Lam S...C..., Ng L..., Pang R...W...C..., Hung I...F...N..., Tan V...P...Y..., Jiang B... and Wong B...C...Y..., Four and a half LIM protein 2 (FHL2) negatively regulates the transcription of E-cadherin through interaction with Snail1, European Journal of Cancer. 2011, 47(1): 121-130.

Zhang W..., Yang Y..., Jiang B..., Peng J., Tu S..., Sardet C..., Zhang Y..., Pang R...W...C..., Hung I...F...N..., Tan V...P...Y..., Lam S...C..., Wang J... and Wong B...C...Y..., XIAP-associated factor 1 interacts with and attenuates the trans-activity of four and a half LIM protein 2, Molecular Carcinogenesis. 2010, 50: 199-207.

Researcher : Wong BCY

Project Title:	Effect of XAF1 gene on tumor growth in gastric and colon cancer
Investigator(s):	Wong BCY, Tu S
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2003

Project Title:	Role of Bcl-2 family proteins in non-steroidal anti-inflammatory drug-induced apoptosis of gastric cancer
Investigator(s):	Wong BCY, Xia HHX
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004

List of Research Outputs

Chen W.J., Chow A.K., Ng L., Poon R.T.P., Wong B.C.Y. and Pang R.W.C., Identification of CD44+ Cancer Cells in Gastric Cancer by Chemotherapeutic Enrichment, Submitted. 2010.

Chow K.M., Chu A.C.Y., Poon R.T.P., Wong B.C.Y. and Pang R.W.C., Blockade of Raf/MEK/ERK Pathway by Raf265 Inhibits Tumor Growth Via in Colorectal Cancer , 17th Hong Kong International Cancer Congress. 2010.

Lam P.K.Y., Ng M.L., Cheung T.K., Wong B.Y.H., Tan V.P.Y., Fong D.Y.T., Wei W.I. and Wong B.C.Y., Rabeprazole is effective in treating laryngopharyngeal reflux, In: C. Mel Wilcox, M.D., Clinical Gastroenterology and Hepatology. Elsevier, 2010, 8: 770-776.

Ma J., Wang J., Zhang W., Zou B., Chen W., Lam S.C., Chen M., Pang R.W.C., Tan V.P.Y., Hung I.F.N., Lan H.Y., Wang Q. and Wong B.C.Y., Promoter hypermethylation and histone hypoacetylation contribute to Pancreatic-duodenal homeobox 1 (PDX1) silencing in gastric cancer., Carcinogenesis. 2010, 31(9): 1552-60.

Tan V.P.Y. and Wong B.C.Y., Helicobacter pylori and gastritis: Untangling a complex relationship 27 years on., In: Geoff Farrell, Journal Of Gastroenterology And Hepatology. Wiley InterScience, 2011, Suppl 1: 42-5.

Tan V.P.Y. and Wong B.C.Y., One size does not fit all - time to regionalize Helicobacter pylori eradication?, In: Roy Pounder NJ Talley, Alimentary Pharmacology and Therapeutics. Wiley InterScience, 2010, 32(3): 506-7.

Tan V.P.Y. and Wong B.C.Y., Patients vote with their feet for 'On demand' rabeprazole in the maintenance treatment phase of reflux oesophagitis., In: Roy Pounder NJ Talley, Alimentary Pharmcology And Therapeutics Journal. Wiley InterScience, 2010, 32(2): 305-7.

Tan V.P.Y., Yan B.P., Hunt R.H. and Wong B.C.Y., Proton pump inhibitor and clopidogrel interaction: the case for watchful waiting., In: Geoff Farrell, Journal Of Gastroenterology And Hepatology. Wiley InterScience, 2010, 25(8): 1342-7.

Zhang W., Jiang B., Guo Z., Sardet C., Zou B., Lam S.C., Li J., He M., Lan H.Y., Pang R.W.C., Hung I.F.N., Tan V.P.Y., Wang J. and Wong B.C.Y., Four-and-a-half LIM protein 2 promotes invasive potential and epithelial-mesenchymal transition in colon cancer., Carcinogenesis. 2010, 31: 1220-9.

Zou B., Chim J.C.S., Pang R.W.C., Zeng H.U.I., Dai Y., Zhang R., Lam S.C., Tan V.P.Y., Hung I.F.N., Lan H.Y. and Wong B.C.Y., XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification, Molecular Carcinogenesis. 2010, under review.

Researcher : Wong CM

Project Title:	Identification of the novel receptors for two liver-derived endocrine Factors FGF21 and adropin
Investigator(s):	Wong CM
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2011

List of Research Outputs

Tang V.H.M., Siu K.L., Wong C.M. and Jin D., Role of yeast peroxiredoxin, Tsa1p, in DNA damage response, Keystone Symposia Conference, Genomic Instability and DNA Repair. Keystone Symposia, Keystone, Colorado, USA.. 2011.

Researcher : Wong DKH

Project Title:	Identification of hepatitis B virus DNA polymerase sequences to predict virological response to entecavir therapy
Investigator(s):	Wong DKH, Lai CL, Yuen RMF, Fung JYY
Department:	Medicine
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	05/2009

Project Title:	Identification of aberrantly methylated CpG loci in hepatitis B virus-related hepatocellular carcinoma
Investigator(s):	Wong DKH, Yuen RMF, Lai CL, Fung JYY
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2010

Project Title:	Application of COLD-PCR sequencing for the early detection of HBV antiviral drug resistant mutations
Investigator(s):	Wong DKH, Fung JYY, Lai CL, Yuen RMF
Department:	Medicine
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	04/2010

List of Research Outputs

Fung J.Y.Y., Lai C.L., Cheng C.T.K., Wu C.H., Wong D.K.H. and Yuen R.M.F., Mild-to-moderate elevation of alanine aminotransferase increases liver stiffness measurement by transient elastography in patients with chronic hepatitis B. [Epub 2010 Dec 14], Am J Gastroenterol . 2010, 106(3): 492-6.

Fung J.Y.Y., Seto W.K., Lai C.L., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Profiles of HBV DNA in a large population of Chinese patients with chronic hepatitis B: implications for antiviral therapy., Journal of hepatology : the journal of the European Association for the Study of the Liver. 2011, 54: 195-200.

Fung J.Y.Y., Lai C.L., Seto W.K., Wong D.K.H. and Yuen R.M.F., Prognostic significance of liver stiffness for hepatocellular carcinoma and mortality in HBeAg-negative chronic hepatitis B., Journal of Viral Hepatitis. 2010, [Epub ahead of print].

Fung J.Y.Y., Lai C.L., Yuen J.C.H., Cheng C.T.K., Wu C.H., Wong D.K.H., Seto W.K., Hung I.F.N. and Yuen R.M.F., Randomized trial of lamivudine versus entecavir in entecavir-treated patients with undetectable hepatitis B virus DNA: Outcome at 2 years., Hepatology. 2011, 53(4): 1148-53.

Fung J.Y.Y., Lai C.L., But D.Y.K., Hsu A.S.J., Seto W.K., Cheng C.T.K., Wong D.K.H. and Yuen R.M.F., Reduction of liver stiffness following resolution of acute flares of chronic hepatitis B., Hepatol Int . 2010, 4(4): 716-22.

Fung J.Y.Y., Lai C.L., Wong D.K.H., Seto W.K. and Yuen R.M.F., Significant changes in liver stiffness measurement using transient elastography in hepatitis B patients – 3 year follow-up study. , Hepatology. 2010, 52(4 Suppl): 411A.

Fung J.Y.Y., Lai C.L., Wong D.K.H., Seto W.K., Hung I.F.N. and Yuen R.M.F., Significant changes in liver stiffness measurements in patients with chronic hepatitis B: 3 year follow-up study. [Epub 2011 Jan 7], J Viral Hepat . 2011, 18(7): e200-5.

Fung J.Y.Y., Lai C.L., Wong D.K.H., Seto W.K. and Yuen R.M.F., Switching to lamivudine in entecavir-treated patients with undetectable HBV DNA – final results at 96 weeks., Hepatology. 2010, 52(4 Suppl): 144A.

Seto W.K., Lai C.L., Fung J.Y.Y., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Elevation of ALT fails to predict significant histologic abnormalities in chronic hepatitis B patients. , Hepatol Int . 2011, 5: 164.

Seto W.K., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Hung I.F.N. and Yuen R.M.F., HBV DNA levels after 12 weeks of telbivudine treatment in chronic hepatitis B predicts long-term outcome., Hepatology . 2010, 52(4 Suppl): 143A.

Seto W.K., Lai C.L., Fung J.Y.Y., Hung I.F.N., Yuen J.C.H., Young J.L.P., Wong D.K.H. and Yuen R.M.F., Natural history of chronic hepatitis C: Genotype 1 versus genotype 6, 2010, 53: 444-8.

Seto W.K., Lai C.L., Fung J.Y.Y., Hung I.F.N., Yuen J.C.H., Young J.L.P., Wong D.K.H. and Yuen R.M.F., Natural history of chronic hepatitis C: genotype 1 versus genotype 6., Journal of hepatology : the journal of the European Association for the Study of the Liver. 2010, 53(3): 444-8.

Seto W.K., Lai C.L., Fung J.Y.Y., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Outcome of 4-year tratemnt of entecavir for treatment-naïve chronic hepatitis B - Poster presentation, 46 ^th Annual Meeting of the European Association for the Study of the Liver - The International Liver Congress™ 2011 in Berlin, Germany between March 30 - April 3. 2011, Abstract No. 748.

Seto W.K., Lai C.L., Fung J.Y.Y., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Outcome of 4-year treatment of entecavir for treatment-naive chronic hepatitis B., J Hepatol . 2011, 54: S301.

Seto W.K., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Hung I.F.N. and Yuen R.M.F., Significance of HBV DNA levels at 12 weeks of telbivudine treatment and the 3 years treatment outcome. {Epub ahead of print], J Hepatol. 2010, 55(3): 522-8.

Tang L., Pu Y., Wong D.K.H., Liu T., Tang H., Xiang T., Yuen R.M.F. and Ren G., The hepatitis B virus-associated estrogen receptor alpha (ER{alpha}) was regulated by microRNA-130a in HepG2.2.15 human hepatocellular carcinoma cells. [Epub ahead of print], Acta Biochim Biophys Sin . 2011.

Wong D.K.H., Lai C.L., Seto W.K., Fung J.Y.Y., Huang F.Y., Hung I.F.N. and Yuen R.M.F., Efficacies of one year nucleos(t)ide analogue therapy in intrahepatic HBV DNA and covalently closed circular DNA reduction. , J Hepatol (Poster presentation at the 46th Annual Meeting of EASL, Berlin, March 30 - April 3, 2011).. 2011, 54: S303.

Wong D.K.H., Huang F.Y., Poon R.T.P., Lai C.L., Fung J.Y.Y., Seto W.K., Hung I.F.N. and Yuen R.M.F., HBV replicative activity in patients with cryptogenic cause of hepatocellular carcinoma, Hepatology. 2010, 52: 247A.

Yeung P., Wong D.K.H., Lai C.L., Fung J.Y.Y., Seto W.K. and Yuen R.M.F., Association of Hepatitis B Virus Pre-S Deletions with the Development of Hepatocellular Carcinoma in Chronic Hepatitis B, Journal of Infectious Diseases. 2011, 203: 646-54.

Yeung P., Wong D.K.H., Lai C.L., Fung J.Y.Y., Seto W.K. and Yuen R.M.F., Association of hepatitis B virus pre-S deletions with the development of hepatocellular carcinoma in chronic hepatitis B. 2011;, J Infect Dis . 2011, 203(5): 646-54.

Yeung P., Wong D.K.H., Lai C.L., Fung J.Y.Y., Seto W.K. and Yuen R.M.F., Profile of pre-S deletions in the natural history of chronic hepatitis B infection, Journal of Medical Virology. 2010, 82: 1843-9.

Yeung P., Wong D.K.H., Lai C.L., Fung J.Y.Y., Seto W.K. and Yuen R.M.F., Profile of pre-S deletions in the natural history of chronic hepatitis B. 2010;, J Med Virol . 2010, 82(11): 1843-9.

Yuen R.M.F., Lee C.K., Wong D.K.H., Fung J.Y.Y., Hung I.F.N., Hsu A., But D.Y.K., Cheung T.K., Chan P., Yuen J.C.H., Fung F.K.C., Seto W.K., Lin C.K. and Lai C.L., Prevalence of occult hepatitis B infection in a highly endemicea for chronic hepatitis B: A study of large blood-donor population, GUT. 2010, 59(10): 1389-93.

Yuen R.M.F., Seto W.K., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H. and Lai C.L., Three years of continuous entecavir therapy in treatment-naïve chronic hepatitis B patients: viral suppression, viral resistance and clinical safety. [Epub 2011 Mar 1], Am J Gastroenterol . 2011, 106(7): 1264-71.

Yuen R.M.F., Wong D.K.H., Lee C.K., Tanaka Y., Allain J.P., Fung J.Y.Y., Leung J., Lin C.K., Sugiyama M., Sugauchi F., Mizokami M. and Lai C.L., Transmissibility of hepatitis B virus (HBV) infection through blood transfusion from blood donors with occult hepatitis B virus infection. [Epub 2011 Jan 18], Clin Infect Dis. 2011, 52(5): 624-32.

Researcher : Wong KS

List of Research Outputs

Cheung B.M.Y., Ong K.L., Jiang C.Q., Liu B., Jin Y.L., Tso A.W.K., Tam S., Wong K.S., Tomlinson B., Lin J.M., Yue X.J., Lam K.S.L., Lam T.H. and Thomas G.N., Association of a genetic variant in the apolipoprotein A5 gene with the metabolic syndrome in Chinese, Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Researcher : Wong KY

List of Research Outputs

Chim J.C.S., Wong K.Y., Leung C.Y., Chung L.P., Hui P.K., Chan S.Y. and Yu L., Epigenetic inactivation of the hsa-miR-203 in haematological malignancies, J Cell Mol Med. 2011, [Epub ahead of print].

Wong K.Y., Yu L. and Chim J.C.S., DNA methylation of tumor suppressor microRNA genes: a lesson from miR-34 family, Epigenomics. 2011, 3(1): 83-92.

Wong K.Y., So J.C.C., Loong F., Chung L.P., Lam W.W.L., Liang R.H.S., Jin D. and Chim J.C.S., Epigenetic inactivation of the miR-124-1 in haematological malignancies, PLoS One. 2011, 22;6(4).

Wong K.Y., Liang R.H.S., So J.C.C., Jin D., Costello J.F. and Chim J.C.S., Epigenetic silencing of MIR203 in multiple myeloma, Br J Haematol. 2011, [Epub ahead of print].

Wong K.Y., Liang R.H.S., So C.H.I.-.C.H.I.U., Qi Y.A.N.T.I.N.G., Jin D.O.N.G.-.Y.A.N., Costello J.O.S.E.P.H. .F... and Chim J.C.S., Epigenetic silencing of miR-203 in multiple myeloma, Br J Haematol. 2011, [Epub ahead of print].

Researcher : Wong LC

List of Research Outputs

Chen C., Zhang X., Wong L.C., Chung S.K., Xu A. and Lam K.S.L., Adipose Tissue-specific Suppression Of C-jun Terminal Kinase Attenuates Obesity-related Metabolic Disorders In A Genetic Mouse Model Of Obesity And Type 2 Diabetes, ADA 2011.

Chu L.W., Tam S., Wong L.C., Yik P.Y., Song Y., Cheung B.M.Y., Morley J.E. and Lam K.S.L., Bioavailable Testosterone Predicts a Lower Risk of Alzheimer's Disease in Older Men, J Alzheimers Dis. 2010, 21(4): 1335-1345.

Zhang X., Xu A., Chung S.K., Cresser J.H., Sweeney G., Wong L.C., Lin A. and Lam K.S.L., Selective inactivation of c-Jun NH2-terminal kinase in adipose tissue protects against diet-induced obesity and improves insulin sensitivity in both liver and skeletal muscle in mice, Diabetes . 2011, 60: 486-95.

Researcher : Wong LY

List of Research Outputs

Yiu Y.F., Chan Y.H., Yiu K.H., Siu D.C.W., Chan H.T., Li S.W., Wong L.Y., Tam S., Lau C.P. and Tse H.F., Vitamin D Deficiency Is Associated With Depletion Of Circulating Endothelial Progenitor Cells And Endothelial Dysfunction In Patients With Type II Diabetes, European Society of Cardiology Annual Congress 2010. European Heart Journal (Supp) 2010 P4690, 2010 . 2010.

Yiu Y.F., Chan Y.H., Yiu K.H., Siu D.C.W., Li L.S.W., Wong L.Y., Lee S.W.L., Tam S., Wong E.W.K., Cheung B.M.Y. and Tse H.F., Vitamin D deficiency is associated with depletion of circulating endothelial progenitor cells and endothelial dysfunction in patients with type 2 diabetes. , J Clin Endocrinol Metab. 2011, 96(5): E830-835.

Researcher : Wong LYF

Project Title:	Involvement of NF-κB and cAMP-dependent protein kinase pathways in adrenomedullin-induced cytokine responses in macrophages
Investigator(s):	Wong LYF, Cheung BMY
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Project Title:	Mechanism of the modulation of cytokine responses by adrenomedullin and adrenomedullin binding protein-1 in macrophages: a novel pathway in sepsis with therapeutic implications
Investigator(s):	Wong LYF, Cheung BMY
Department:	Medicine
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	10/2006

Researcher : Wong MKY

List of Research Outputs

Lam B., Wong M.K.Y., Lu K.H., Au W.Y., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Liang R.H.S., Lam W.K., Ip M.S.M. and Lie A.K.W., Effects of Azithromycin in bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation – a randomized double-blinded placebo-controlled study, Bone Marrow Transplantation. 2011, Epub ahead of print.

Lam C.L.D., Lam B., Wong M.K.Y., Lu K.H., Au W.Y., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Liang R.H.S., Lam W.K., Ip M.S.M. and Lie A.K.W., Effects of Azithromycin in bronchiolitis obliterans syndrome after hematopoietic SCT-a randomized double-blinded placebo-controlled study, Bone marrow transplantation. 2011, Epub ahead of print.

Wong M.K.Y., Loong F., Khong P.L., Kwong Y.L. and Leung A.Y.H., Mediastinal cryptococcosis masquerading as therapy-refractory lymphoma, Annals of Hematology. 2010, Epub.

Researcher : Wong RMY

List of Research Outputs

Yiu K.H., Yeung C.K., Chan K.H.T., Wong R.M.Y., Tam S., Lam K.F., Yan G., Yue W., Chan H.H.L. and Tse H.F., Increased arterial stiffness in patients with psoriasis is associated with active systemic inflammation, British Journal of Dermatology. British Association of Dermatologists, 2011, 164: 514-520.

Researcher : Wong RWS

List of Research Outputs

Mok T.M.Y., Yiu K.H., Wong C.Y., Qiuwaxi J., Lai W.H.K., Wong R.W.S., Tse H.F. and Lau W.C.S., Low circulating level of CD133+KDR+cells in patients with systemic sclerosis., Clinical and Experimental Rheumatology. 2010, 28(5 Suppl 62): S19-25.

Yang J., Yang W., Hirankarn N., Ye D.Q., Zhang Y., Pan H.F., Mok C.C., Chan T.M., Wong R.W.S., Mok M.Y., Lee K.W., Wong S.N., Leung A.M.H., Li X.P., Avihingsanon Y., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Shotelersuk V., Baum L., Kwan P., Lee T.L., Ho M.H.K., Lee P.P.W., Wong W.H.S., Zeng S., Zhang J., Wong C.M., Ng I.O.L., Garcia-Barcelo M.M., Cherny S.S., Tam P.K.H., Sham P.C., Lau W.C.S. and Lau Y.L., ELF1 is associated with systemic lupus erythematosus in Asian populations, Human Molecular Genetics. 2011, 20(3): 601-607.

Zhang Y., Yang W., Mok C.C., Chan T.M., Wong R.W.S., Mok T.M.Y., Lee K.W., Wong S.N., Leung A.M.H., Lee T.L., Ho M.H.K., Lee P.P.W., Wong W.H.S., Yang J., Zhang J., Wong C.M., Ng I.O.L., Garcia-Barcelo M.M., Cherny S.S., Tam P.K.H., Sham P.C., Lau W.C.S. and Lau Y.L., Two missense variants in UHRF1BP1 are indpendently associated with systemic lupus erythematosus in Hong Kong Chinese, Genes and Immunity. 2011, 12(3): 231-234.

Researcher : Wong S.Y.

List of Research Outputs

Cheung B...M...Y..., Hung I...F...N... and Wong S...Y..., Proton Pump Inhibitors - a Sting in the Tale?, The Hong Kong Medical Daily. 2010, 15: 4-5.

Researcher : Wong W

List of Research Outputs

Lam C.L.K., Wong W. and Lam T.P., Workshop On "cross-cultural Translation And Validation Of Health-related Quality Of Life Measuers", Hong Kong Society for Quality of Life Annual General Meeting, Hong Kong. 2010.

Researcher : Wong Y

List of Research Outputs

Tan K.C.B., Wang Y., Shiu S.W.M., Wong Y., Yung S.S.Y. and Chan D.T.M., Adenosine triphosphate binding cassette transporter G1-mediated cholesterol efflux to serum is impaired in type 2 diabetes mellitus, American Diabetes Association 71st Scientific Sessions, San Diego, USA. San Diego, USA, 2011.

Tan K.C.B., Shiu S.W.M., Wong Y. and Tam H.L., Serum advanced glycation end products is associated with insulin resistance independent of adiponectin, 46thEuropean Association for the Study of Diabetes Annual Meeting, Stockholm, Sweden. 2010.

Researcher : Wong YL

List of Research Outputs

Hoo R.L.C., Wong Y.L., Qiao C.F., Xu A., Xu H.X. and Lam K.S.L., he effective fraction isolated from Radix Astragali alleviates glucose intolerance, insulin resistance and hypertriglyceridemia in db/db diabetic mice through its anti-inflammatory activity, Nutr Metab. 2010, 7: 67.

Researcher : Wu CH

List of Research Outputs

Fung J.Y.Y., Lai C.L., Cheng C.T.K., Wu C.H., Wong D.K.H. and Yuen R.M.F., Mild-to-moderate elevation of alanine aminotransferase increases liver stiffness measurement by transient elastography in patients with chronic hepatitis B. [Epub 2010 Dec 14], Am J Gastroenterol . 2010, 106(3): 492-6.

Fung J.Y.Y., Lai C.L., Yuen J.C.H., Cheng C.T.K., Wu C.H., Wong D.K.H., Seto W.K., Hung I.F.N. and Yuen R.M.F., Randomized trial of lamivudine versus entecavir in entecavir-treated patients with undetectable hepatitis B virus DNA: Outcome at 2 years., Hepatology. 2011, 53(4): 1148-53.

Researcher : Wu H

List of Research Outputs

Mok T.M.Y., Wu H., Lo Y. and Lau W.C.S., Serum IL-17 and IL-23 to Th1/Th2 cytokines and disease activity in systemic lupus erythematosus., The Journal of Rheumatology. 2010, 37(10): 2046-2052.

Mok T.M.Y., Wu H., Lo Y. and Lau W.C.S., The relation of interleukin 17 (IL-17) and IL-23 to Th1/Th2 cytokines and disease activity in systemic lupus erythematosus., The Journal of Rheumatology. 2010, 37(10): 2046-2052.

Wu H., Wu W. and Li G., Rate-dependent block of hKv1.5 channels and the molecular determinants by the natural flavone acacetin, International Academy of Cardiology 15th World Congress on Heart Disease Annual Scientific Sessions, Vancouver, BC, Canada; July 24-27, 2010.. 2010.

Wu H., Wu W. and Li G.R., Rate-dependent block of hkv1.5 channels and the molecular determinant by the natural flavone acacetin, J HK Coll Cardiol. 2010. 18(2): 78.

Wu H., Wu W., Lau C.P., Vanhoutte P.M.G.R. and Li G.R., Use-dependent block of hKv1.5 channels and the molecular determinant by the natural flavone acacetin, 16th Medical Research Conference, Department of Medicine, HKU. 2011, 17(1): 60.

Researcher : Wu H

List of Research Outputs

Mok T.M.Y., Wu H., Lo Y. and Lau W.C.S., Serum IL-17 and IL-23 to Th1/Th2 cytokines and disease activity in systemic lupus erythematosus., The Journal of Rheumatology. 2010, 37(10): 2046-2052.

Wu H., Wu W. and Li G.R., Rate-dependent block of hkv1.5 channels and the molecular determinant by the natural flavone acacetin, J HK Coll Cardiol. 2010. 18(2): 78.

Researcher : Wu W

List of Research Outputs

Wu H., Wu W. and Li G., Rate-dependent block of hKv1.5 channels and the molecular determinants by the natural flavone acacetin, International Academy of Cardiology 15th World Congress on Heart Disease Annual Scientific Sessions, Vancouver, BC, Canada; July 24-27, 2010.. 2010.

Wu H., Wu W. and Li G.R., Rate-dependent block of hkv1.5 channels and the molecular determinant by the natural flavone acacetin, J HK Coll Cardiol. 2010. 18(2): 78.

Wu H., Wu W., Lau C.P., Vanhoutte P.M.G.R. and Li G.R., Use-dependent block of hKv1.5 channels and the molecular determinant by the natural flavone acacetin, 16th Medical Research Conference, Department of Medicine, HKU. 2011, 17(1): 60.

Wu W., Lau C.P., Tse H.F. and Li G.R., Beta1 subunit-dependent modulation of BK channel by membrane cholesterol, J HK Coll Cardiol. 2010. 18(2): 65.

Wu W., Lau C.P., Tse H.F. and Li G.R., Effects of increased cholesterol level on BK channels, 16th Medical Research Conference, Department of Medicine, HKU. 2011, 17(1): 61.

Researcher : Xia HHX

Project Title:	Homeobox genes in gastric carcinogenesis: an in vivo and in vitro study
Investigator(s):	Xia HHX, Wong BCY
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2003

Project Title:	Role of cyclooxygenase in helicobacter pylori-induced gastric carcinogenesis
Investigator(s):	Xia HHX, Wong BCY
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004

Project Title:	Role of macrophage migration inhibitory factor in Helicobacter pylori-induced gastric carcinogenesis
Investigator(s):	Xia HHX, Wong BCY
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2005

Researcher : Xiao S

Project Title:	Replication and Functional Study of Polymorphisms in miRNA Binding Sites and Osteoporosis
Investigator(s):	Xiao S, Kung AWC
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	02/2011

Project Title:	The 3rd Joint Meeting of the European Calcified Tissue Society & the International Bone and Mineral Society ASSOCIATION OF CDX1 BINDING SITE OF PERIOSTIN GENE WITH BONE MINERAL DENSITY AND VERTEBRAL FRACTURE RISK
Investigator(s):	Xiao S
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	05/2011
Completion Date:	05/2011

List of Research Outputs

Bow C.H.Y., Leung E., Cheung C.L., Xiao S., Loong C., Soong S.S., Tan K.C.B., Luckey M.M., Cauley J.A., Fujiwara S. and Kung A.W.C., Ethnic Difference of Clinical Vertebral Fracture Risk, 12th Regional Osteoporosis Conference, Hong Kong. 2011.

Bow C.H.Y., Cheung E., Cheung C.L., Xiao S., Loong C., Soong S.S., Tan K.C.B., Luckey M.M., Cauley J.A., Fujiwara S. and Kung A.W.C., Ethnic difference of clinical vertebral fracture risk, Osteoporosis International. 2011.

Cheung C.L., Xiao S. and Kung A.W.C., Genetic epidemiology of age-related osteoporosis and its clinical application, Nature Reviews Rheumatology. 2010, 6(9): 507-517.

Li H.Y., Cheung C.L., Xiao S., Lau K.S., Gao Y., Bow C.H.Y., Huang Q.Y., Sham P.C. and Kung A.W.C., Identification Of Qtl Genes For Bmd Variation Using Both Linkage And Gene-based Association Approaches., Human Genetics. 2011.

Styrkarsdottir U., Halldorsson B.V., Gudbjartsson D.F., Tang N., Koh J.M., Xiao S., Kwok T., Kim G.S., Chan J., Cherny S., Lee S.H., Kwok A., Ho S.C., Gretarsdottir S., Kostic J., Palsson S., Sigurdsson G., Sham P.C., Kim B., Kung A.W.C., Kim S., Woo J., Leung P.C., Kong A., Thorsteinsdottir U., Stefansson K. and Genetic Factors for Osteoporosis (GEFOS) Consortium , European Bone Mineral Density Loci are also associated with BMD in East-Asian Populations, PLoS ONE. 2010, 5(10): e13217.

Xiao S., Cherny S.S., Li H.Y., Gao Y., Tso H.W., Lau K.S., Luk K.D.K., Sham P.C. and Kung A.W.C., Association Of Jag1 Gene And Its Variant Sequence With Bone Mineral Density And Osteoporotic Fractures: A Genome-wide Association Study And Follow-up Replication Studies, The HKSEMR Annual Scientific Meeting and Annual General Meeting, 21 November, Hong Kong. 2010.

Xiao S., Gao Y., Cheung C.L., Bow C.H.Y., Lau K.S., Sham P.C., Tan K.C.B. and Kung A.W.C., Association of Cdx1 Binding Site of Periostin Gene with Bone Mineral Density and Vertebral Fracture Risk, The 3rd Joint Meeting of the European Calcified Tissue Society and the International Bone and Mineral Society, 7-11 MAY, Athens, Greece. Athens, Greece, 2011, 7-11 MAY.

Xiao S., New Investigator Award, The 3rd Joint Meeting of the European Calcified Tissue Society and the International Bone and Mineral Society. 2011.

Xiao S. and Kung A.W.C., Osteoporosis: Advances of Gene Mapping, The 6th International Huaxia Congress of Endocrinology, 10-12 December, Shanghai, China. Shanghai, China, 2010, 10-12 December.

Xiao S., Web Jee Travel Award , International Conference on Osteoporosis and Bone Research. 2010.

Researcher : Xiao Y

List of Research Outputs

Li F.Y.L., Wang Y., Xiao Y., Lam K.S.L. and Xu A., Endothelial-specific Activation Of Amp-activated Protein Kinase Improves Impairment In Endothelial Repair In Type 1 Diabetic Mice, Sixth International Symposium on Healthy Aging: “A New Golden Age”. 2011.

Researcher : Xiong J

Project Title:	2008 NCRI Cancer Conference Growth inhibitory effect of 5-aza-2'-deoxycytidine on cancer cells is independent of p16 ink4a and p14ARF
Investigator(s):	Xiong J
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	10/2008

Researcher : Xu A

Project Title:	Molecular mechanism underlaying the pathogenesis of type 2 diabetes
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:	05/2007

Project Title:	APPL1 as a novel modulator of endothelial nitric oxide production and endothelium-dependent vasodilation
Investigator(s):	Xu A, Chung SK, Wang Y
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2008
Completion Date:	12/2010

Project Title:	Vascular dysfunction in obesity and diabetes: from risk prediction to therapeutic intervention
Investigator(s):	Xu A, Lam KSL, Vanhoutte PMGR, Tse HF, Wong KB, Wang Y
Department:	Medicine
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2008

Project Title:	Adipocyte fatty acid binding protein as a novel diagnostic marker and therapeutic target to combat vascular complications of diabetes: mechanisms and clinical implications
Investigator(s):	Xu A, Vanhoutte PMGR, Lam KSL
Department:	Medicine
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2009

Project Title:	Protective roles of AMP-activated protein kinase against vascular disease in diabetes: Molecular mechanisms and therapeutic intervention
Investigator(s):	Xu A, Vanhoutte PMGR
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2009

Project Title:	Characterization of Novel Adaptor Proteins Involved in Regulating Insulin Sensitivity and Glucose Homeostasis: from Molecular Mechanism to Physiological Implication
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010

Project Title:	Characterization of the receptor and postreceptor signaling events underlying the metabolic actions of FGF21, a potential therapeutic agent for treating obesity-related medical complications
Investigator(s):	Xu A, Hoo RLC, Wang Y
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2010
Completion Date:	05/2011

Project Title:	Pharmacological inhibition of adipocyte fatty acid binding protein as a new strategy for treating obesity-related cardio-metabolic disorders
Investigator(s):	Xu A, Vanhoutte PMGR, Lam KSL
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2010
Completion Date:	06/2011

Project Title:	APPL2 as a Negative Regulator of Insulin Sensitivity and Glucose Uptake in Skeletal Muscle: A Novel Pathway Leading to Insulin Resistance?
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2011

Project Title:	Genetic and pathogenic pathways leading to type 2 diabetes Mellitus
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:	05/2011

Project Title:	Protective effects of the liver-derived hormone adropin against obesity-related insulin resistance and metabolic disorders
Investigator(s):	Xu A, Wang Y
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2011

Project Title:	71th Scientific Sessions of the American Diabetes Association Genetic Inactivation of Toll-Like Receptor 4 Alleviates Diet-Induced Nonalcoholic Steatohepatitis by Inhibiting Reactive Oxygen Species-Evoked Activation of X-box Binding Protein-1 in ApoE-Deficient Mice
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	06/2011

Project Title:	A Multi-disciplinary Approach to Investigate Vascular Dysfunction in Obesity and Diabetes: From Molecular Mechanism to Therapeutic Intervention
Investigator(s):	Xu A, Vanhoutte PMGR, Wang Y, Lam KSL
Department:	Medicine
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2011

List of Research Outputs

Chang J., Li Y., Huang Y., Lam K.S.L., Hoo R.L.C., Wong W.T., Cheng K.Y., Wang Y., Vanhoutte P.M.G.R. and Xu A., Adiponectin prevents diabetic premature senescence of endothelial progenitor cells and promotes endothelial repair by suppressing the p38 MAP kinase/p16INK4A signaling pathway, Diabetes. 2010, 59: 2949-59.

Chen C., Zhang X., Wong L.C., Chung S.K., Xu A. and Lam K.S.L., Adipose Tissue-specific Suppression Of C-jun Terminal Kinase Attenuates Obesity-related Metabolic Disorders In A Genetic Mouse Model Of Obesity And Type 2 Diabetes, ADA 2011.

Chen C., Tso A.W.K., Cheung B.M.Y., Ong K.L., Wat N.M.S., Edward D J.A.N.U.S., Xu A. and Lam K.S.L., Circulating Pigment Epithelium-Derived Factor Levels and the Risk of Hypertension in a Community-based Study., 16th Medical Research Conference, The University of Hong Kong. 2011.

Chen C., Tso A.W.K., Law S.C., Cheung B.M.Y., Ong K.L., Wat N.M.S., Janus E.D., Xu A. and Lam K.S.L., Plasma Level of Pigment Epithelium-Derived Factor Is Independently Associated with the Development of the Metabolic Syndrome in Chinese Men: A 10-Year Prospective Study. , J Clin Endocrinol Metab.. 2010, 95: 5074-81.

Chen Y., Li D., Tsang J.Y.S., Niu N., Peng J., Zhu J., Hui K.C.W., Xu A., Lui V.C.H., Lamb J.R. and Tam P.K.H., PPAR-y signaling and IL-5 inhibition together prevent chronic rejection of MHC Class II-mismatched cardiac grafts, The Journal of Heart and Lung Transplantation. 2011, 30(6): 698-706.

Cheng K.Y., Lam K.S.L., Wang Y., Zhu W., Hoo R.L.C. and Xu A., Transgenic over-expression of APPL1 improves high-fat diet-induced insulin resistance in liver and skeletal muscle., Sixth International Symposium on Healthy Aging: " A New Golden Age”. 2011.. 2011.

Cheng K.Y., Lam K.S.L., Wang Y., Zhu W. and Xu A., Ubiquitination Is Indispensible For The Insulin-sensitizing Activity Of The Adaptor Protein Appl1. 16th Medical Research Conference. , 16th Medical Research Conference 2011. The University of Hong Kong. 2011.

Cheng K.Y., Lam K.S.L., Chen B., Zhu W., Wang Y. and Xu A., 銜接蛋白質APPL1和APPL2對島素敏感性和葡萄糖代謝的陰陽調控 - 從分子機制到生理作用, 2011.

Cheung B.M.Y., Ong K.L., Xu A., Lam T.H. and Lam K.S.L., Association of genetic variants in gene encoding lipocalin-2 with plasma alanine aminotransferase and aspartate aminotransferase, Presented at the 16th Medical Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong. 2011.

Cheung Y.Y., Tso A.W.K., Cheung B.M.Y., Xu A., Ong K.L., Law S.C., Wat N.M.S., Janus E.D., Sham P.C. and Lam K.S.L., Genetic variants associated with persistent central obesity and the metabolic syndrome in a 12-year longitudinal study, Euro J Endocrinol . 2011, 164: 381-8.

Fang X., Palanivel R., Cresser J., Schram K., Ganguly R., Thong F.S., Tuinei J., Xu A., Abel E.D. and Sweeney G., An APPL1-AMPK signaling axis mediates beneficial metabolic effects of adiponectin in the heart, Am J Physiol Endocrinol Metab. 2010, 299(5): E721-9.

Gao X., Li K., Hui X., Kong X., Sweeney G., Wang Y., Xu A., Teng M., Liu P. and Wu D., Carnitine palmitoyltransferase 1A prevents fatty acid-induced adipocyte dysfunction through suppression of c-Jun N-terminal kinase, Biochem J. 2011, 435(3): 723-32.

Ge X., Chen C., Hui X., Wang Y., Lam K.S.L. and Xu A., Fibroblast Growth Factor-21 Promotes Glucose Uptake through Activation of the serum response factor (SRF)/ Ets-like protein-1 (Elk-1) signaling cascade in Adipocytes, ADA 2011.

Hoo R.L.C., Wong Y.L., Xu A. and Lam K.S.L., The role of fatty acid binding protein in the pathogenesis of obesity-related inflammatory diseases, Research centre of heart, brain and healthy aging. 2011.

Hoo R.L.C., Wong Y.L., Qiao C.F., Xu A., Xu H.X. and Lam K.S.L., he effective fraction isolated from Radix Astragali alleviates glucose intolerance, insulin resistance and hypertriglyceridemia in db/db diabetic mice through its anti-inflammatory activity, Nutr Metab. 2010, 7: 67.

Lam K.S.L., Hoo R.L.C., Wong Y.L. and Xu A., Adipocyte fatty acid binding protein in Kupffer cell mediates non alcoholic fatty liver disease through endoplasmic reticulum stresss and inflammation, Endocrine society meeting 2011.

Li F.Y.L., Cheng K.Y., Lam K.S.L., Vanhoutte P.M.G.R. and Xu A., Cross-talk Between Adipose Tissue And Vasculature: Role Of Adiponectin, Acta Physiologica. 2010.

Li F.Y.L., Wang Y., Xiao Y., Lam K.S.L. and Xu A., Endothelial-specific Activation Of Amp-activated Protein Kinase Improves Impairment In Endothelial Repair In Type 1 Diabetic Mice, Sixth International Symposium on Healthy Aging: “A New Golden Age”. 2011.

Li F.Y.L., Wang Y., Lam K.S.L. and Xu A., Endothelium-specific activation of AMP-activated protein kinase alleviates diabetes-induced impairment in endothelial repair in mice, 16th Medical Research Conference. 2011.

Li F.Y.L., Hoo R.L.C., Lam K.S.L. and Xu A., Outstanding Scientific Work – Winning poster presentation , Frontiers in Cardiovascular Biology; European Society of Cardiology. 2010.

Li F.Y.L., Hoo R.L.C., Lam K.S.L. and Xu A., Toll-like receptor 4 inactivation alleviates impaired vascular reendothelialisation by improving endothelial progenitor cell adhesion, In: Hans Michael Piper, Journal of Cardiovascular Research. United Kingdom, Oxford Journals, 2010, 87: S48.

Li J.P., Fung M.L., Li F., Xu A. and Leung W.K., Calcium Signal Facilitates the Immediate Induction of HIF1alpha by Lipopolysaccharide, 24^th International Association for Dental Research-SEA Division Annual Scientific Meeting, 9/2010.

Li M., Ho J.C.Y., Lai K.W.H., Au K.W., Xu A., Cheung B.M.Y., Lam K.S.L. and Tse H.F., Hypoadiponectinemia and its Impact on circulating endothelial progenitor cells in patients with type 2 diabetes - adiponectin and endothelial progenitor cells, Diabetes/Metab Res Rev. 2010, 27: 185-94.

Li M., Ho J.C.Y., Lai K.W.H., Au K.W., Xu A., Cheung B.M.Y., Lam K.S.L. and Tse H.F., The decrement in circulating endothelial progenitor cells (EPCs) in type 2 diabetes is independent of the severity of the hypoadiponectemia, Diabetes Metab Res Rev. 2011, 27(2): 185-194.

Liu X., Huang X., Lin W., Wang D., Diao Y., Li H., Hui X., Wang Y., Xu A., Wu D. and Ke D., New aromatic substituted pyrazoles as selective inhibitors of human adipocyte fatty acid-binding protein, Bioorg Med Chem Lett. 2011, 21(10): 2949-52.

Michele Y.U.E.N., Wing Sun C.H.O.W., Chen C., Ting Chung P.U.N., Law S.C., Tso A.W.K., Xu A. and Lam K.S.L., . Circulating Plasma Pigment Epithelium-Derived Factor (PEDF) Levels Are Associated with Insulin Resistance in Women with Estrogen Deficiency, 71th American Diabetes Association Scientific Sessions, San Diego, CA. 2011.

Ong K.L., Li M., Tso A.W.K., Xu A., Cherny S.S., Sham P.C., Tse H.F., Lam T.H., Cheung B.M.Y. and Lam K.S.L., Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese. , European Journal of Endocrinology. 2010, 163: 251-257.

Park M., Youn B., Zheng X.L., Wu D., Xu A. and Sweeney G., Globular adiponectin, acting via AdipoR1/APPL1, protects H9c2 cells from hypoxia/reoxygenation-induced apoptosis, PLoS One. 2011, 6(4): e19143.

Tian X.Y., Wong W.T., Xu A., Chen Z.Y., Lu Y., Liu L.M., Lee V.W., Lau C.W., Yao X. and Huang Y., Rosuvastatin Improves Endothelial Function of db/db Mice: Role of Angiotensin II Type 1 Receptors and Oxidative Stress, Br J Pharmacol. 2011.

Tsang J.Y.S., Li D., Ho D., Peng J., Xu A., Lamb J.R., Chen Y. and Tam P.K.H., Novel immunomodulatory effects of adiponectin on dendritic cell functions, International Immunopharmacology. 2011, 11(5): 604-609.

Tso A.W.K., Lam T.K.Y., Xu A., Yiu K.H., Tse H.F., Li L.S.W., Law S.C., Cheung B.M.Y., Cheung R.T.F. and Lam K.S.L., Serum adipocyte fatty acid-binding protein is associated with ischemic stroke and early death, Neurology. 2011, 76(23): 1968-75.

Wen L., Yang Y., Wang Y., Xu A., Wu D. and Chen Y., Appl1 Is Essential For The Survival Of Xenopus Pancreas, Duodenum, And Stomach Progenitor Cells., Dev Dyn. . 2010, 239: 2198-207.

Wong S.L., Lau C.W., Wong W.T., Xu A., Au C.L., Ng C.F., Ng S.S., Gollasch M., Yao X. and Huang Y., Pivotal role of protein kinase Cdelta in angiotensin II-induced endothelial cyclooxygenase-2 expression: a link to vascular inflammation, Arterioscler Thromb Vasc Biol. 2011, 31(5): 1169-76.

Wong W.T., Tian X.Y., Xu A., Ng C.F., Lee H.K., Chen Z.Y., Au C.L., Yao X. and Huang Y., Angiotensin Ii Type 1 Receptor-dependent Oxidative Stress Mediates Endothelial Dysfunction In Type 2 Diabetic Mice, Antioxid Redox Signal. . 2010, 13: 757-68.

Xu A., Cardiovascular Drugs and Therapy. 2010.

Xu A., New Aspects Of Metabolic Syndrome , 42nd Annual Scientific Meeting Of Japan Atherosclerosis Society . Japanese atherosclerosis Society, 2010.

Xu A., Vascular Protective Effects of Adiponectin: Mechanisms and Therapeutic Implications, The 12th International Symposium On “vascular Neuroeffector Mechanisms”. European Physiology Society, 2010.

Xu A., Wang Y., Lam K.S.L. and Vanhoutte P.M.G.R., Vascular actions of adipokines molecular mechanisms and therapeutic implications, Adv Pharmacol. 2010, 60: 229-55.

Ye D., Li F.Y.L., Lam K.S.L., Wang Y. and Xu A., Genetic Inactivation of Toll-Like Receptor 4 Alleviates Diet-induced Nonalcoholic Steatohepatitis by Inhibiting Reactive Oxygen Species-evoked Activation of X-box Binding Protein-1 in ApoE-deficient Mice, ADA 2011.

Yu H., Xia F., Lam K.S.L., Wang Y., Bao Y., Zhang J., Gu Y., Zhou P., Lu J., Jai W. and Xu A., Circadian Rhythm of Circulating Fibroblast Growth Factor 21 (FGF21) is Related to Diurnal Changes in Free Fatty Acids in Humans., Clinical Chemistry. 2011.

Zhang X., Lam K.S.L., Ye H., Chung S.K., Zhou M., Wang Y. and Xu A., Adipose tissue-specific inhibition of hypoxia-inducible factor 1{alpha} induces obesity and glucose intolerance by impeding energy expenditure in mice, J Biol Chem. 2010, 285: 32869-77.

Zhang X., Xu A., Chung S.K., Cresser J.H., Sweeney G., Wong L.C., Lin A. and Lam K.S.L., Selective inactivation of c-Jun NH2-terminal kinase in adipose tissue protects against diet-induced obesity and improves insulin sensitivity in both liver and skeletal muscle in mice, Diabetes . 2011, 60: 486-95.

Zhu W., Cheng K.Y., Chen B., Wang Y., Lam K.S.L. and Xu A., APPL2 inhibits insulin-stimulated glucose uptake through both Akt and its downstream target TBC1D1 in skeletal muscle, 16th Medical Research Conference. The University of Hong Kong, Hong Kong. . 2011.

Researcher : Xu J

Project Title:	Search for susceptibility gene loci for maturity-onset diabetes of the young in Southern Chinese
Investigator(s):	Xu J, Lam KSL, Sham PC
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Researcher : Yan G

List of Research Outputs

Siu D.C.W., Yiu K.H., Lee K.L.F., Yan G., Lee S.W.L., Lau C.P. and Tse H.F., Effects of Right Low Atrial Septal versus Right Atrial Appendage Pacing on Atrial Mechanical Function and Dyssynchrony in Patients with Sinus Node Dysfunction and Paroxysmal Atrial Fibrillation, European Journal of Echocardiography. 2010, 11: 672.

Siu D.C.W., Yan G., Yue W., Lee K.L.F., Lee S.W.L., Lau C.P. and Tse H.F., Effects of right low atrial septal versus right atrial appendage pacing on atrial mechanical function and dyssynchrony in patients with sinus node dysfunction and paroxysmal atrial fibrillation , Heart Rhythm. 2011.

Siu D.C.W., Yiu K.H., Yan G., Yue W., Lee K.L.F., Lee S.W.L., Lau C.P. and Tse H.F., Effects of right low atrial septal versus right atrial appendage pacing on atrial mechanical function and dyssynchrony in patients with sinus node dysfunction and paroxysmal atrial fibrillation, European Society of Echocardiogram. 2010.

Siu D.C.W., Lee K.L.F., Yue W., Yan G., Lee S.W.L., Lau C.P. and Tse H.F., Effects of right low atrial septal versus right atrial appendage pacing on strial mechanical function and dyssynchrony in patients with sinus node dysfunction and paroxysmal atrial fibrillation. , Heart Rhythm. 2011.

Wang M.M., Siu D.C.W., Yan G., Yue W., Lee K.L.F., Lee S.W.L., Lau C.P. and Tse H.F., Effects of right low atrial septal versus right atrial appendage pacing on atrial mechanical function and dyssynchrony in patients with sinus node dysfunction and paroxysmal atrial fibrillation , Heart Rhythm. 2011.

Wang M.M., Yan G., Yue W., Siu D.C.W., Yiu K.H., Lee S.W.L. and Tse H.F., Left ventricular mechanical dyssynchrony predicts exercise capacity in patients with coronary artery disease and narrow QRS duration, Journal of The American Society of Echocardiography. 2011.

Yan G., Wang M.M., Yue W., Luk T.H., Dai Y.L.E., Siu D.C.W., Yiu K.H., Lee S.W.L. and Tse H.F., Coenzyme Q10 Supplementation Improves Left Ventricular Torsion In Patients With Ischemic Cardiomyopathy, AHA. 2010.

Yiu K.H., Yeung C.K., Chan K.H.T., Wong R.M.Y., Tam S., Lam K.F., Yan G., Yue W., Chan H.H.L. and Tse H.F., Increased arterial stiffness in patients with psoriasis is associated with active systemic inflammation, British Journal of Dermatology. British Association of Dermatologists, 2011, 164: 514-520.

Yue W., Wang M.M., Yan G., Yiu K.H., Yin L.X., Lee S.W.L., Siu D.C.W. and Tse H.F., Smoking is associated with depletion of circulating endothelial progenitor cells and elevated pulmonary artery pressure in patients with coronary artery disease , American Journal of Cardiology . 2010, 2010 Nov 1;106(9):1248-54.

Researcher : Yau TCC

Project Title:	The Role of Serial Changes in Circulating Angiogenic Markers in Predicting the Clinical Outcome of Advanced Hepatocellular Carcinoma (HCC) Patients on Sorafenib
Investigator(s):	Yau TCC, Fan ST, Poon RTP, Pang RWC
Department:	Surgery
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2011

List of Research Outputs

Chan P., Wong H., Yao T.J., Tang V.W.K., Wong H., Fan S.T., Poon R.T.P. and Yau T.C.C., The outcomes of elderly patients with advanced hepatocellular carcinoma treated with single agent Sorafenib (Abstract), The 7th International Meeting Hepatocellular Carcinoma Eastern and Western Experiences, Paris, France, 14-15 January 2011.

Wong H., Leung R.C.Y., Lau S., Chiu J., Cheung P., Wong T., Liang R., Epstein R. and Yau T.C.C., Presence of an in-situ component predicts reduced tumor aggressiveness in luminal subtype of invasive breast cancer (Abstract), Primary Therapy of Early Breast Cancer - 11th International Conference. St.Gallen, Switzerland, 16-19 March 2011. The Breast. 2011, 20(Suppl 1): S39.

Yau T.C.C., Chan P., Cheung F.Y., Lee A.S., Yau T.K., Choo S.P., Toh H.C., Leung A.K., Wong J.S., Wong S., Lau J., Pang R.W.C., Fan S.T. and Poon R.T.P., Efficacy and tolerability of Sorafenib, Capecitabine and Oxaliplatin (Secox) in patients with advanced hepatocellular carcinoma: a multi-centre phase II study (Abstract), The 7th International Meeting Hepatocellular Carcinoma Eastern and Western Experiences, Paris, France, 14-15 January 2011.

Yau T.C.C., Chan P., Pang R.W.C., Ng K.K.C., Fan S.T. and Poon R.T.P., Phase 1-2 trial of PTK787/ZK222584 combined with intravenous doxorubicin for treatment of patients with advanced hepatocellular carcinoma: implication for antiangiogenic approach to hepatocellular carcinoma, Cancer. 2010, 116(21): 5022-5029.

Researcher : Ye D

List of Research Outputs

Ye D., Li F.Y.L., Lam K.S.L., Wang Y. and Xu A., Genetic Inactivation of Toll-Like Receptor 4 Alleviates Diet-induced Nonalcoholic Steatohepatitis by Inhibiting Reactive Oxygen Species-evoked Activation of X-box Binding Protein-1 in ApoE-deficient Mice, ADA 2011.

Researcher : Yeung CK

List of Research Outputs

Lam T.P., Yeung C.K. and Lam K.F., What are the learning outcomes of a short postgraduate training course in dermatology for primary care doctors?, BMC Medical Education. 2011, 11: 20.

Yiu K.H., Yeung C.K., Chan K.H.T., Wong R.M.Y., Tam S., Lam K.F., Yan G., Yue W., Chan H.H.L. and Tse H.F., Increased arterial stiffness in patients with psoriasis is associated with active systemic inflammation, British Journal of Dermatology. British Association of Dermatologists, 2011, 164: 514-520.

Researcher : Yeung HM

List of Research Outputs

Kong M.C.W., Poon N.Y.E., Yeung H.M., Rushing S.N., Chen G. and Li R.A., MicroRNA-21 promotes survival but not functional maturation of human embryonic stem cell derived cardiomyocytes (hESC-CMs), 16th MRC, HKU. 2010.

Poon N.Y.E., Kong M.C.W., Yeung H.M., Rushing S.N., Li Y.S. and Li R.A., MiR-29b negatively regulates cell cycle activity of human embryonic stem cell-derived cardiomyocytes, 16th MRC, HKU. 2010.

Researcher : Yeung JSL

List of Research Outputs

Jin O., Kavikondala S., Sun L.Y., Gu J.R., Fu R., Mok T.M.Y., Chan W.K., Yeung J.S.L., Nie Y. and Lau W.C.S., Abnormalities in circulating plasmacytoid dendritic cells in patients with systemic lupus erythematosus., Arthritis Research & Therapy. 2010, 12(4): R137.

Researcher : Yeung P

List of Research Outputs

Yeung P., Wong D.K.H., Lai C.L., Fung J.Y.Y., Seto W.K. and Yuen R.M.F., Profile of pre-S deletions in the natural history of chronic hepatitis B. 2010;, J Med Virol . 2010, 82(11): 1843-9.

Researcher : Yeung SC

List of Research Outputs

CHN L.O.O.N.G., Bow C.H.Y., Yeung S.C., Tan K.C.B. and Kung A.W.C., Bone Mineral Density in Patients with Spine Fracture Treated with Alendronate Sodium and Strontium Ranelate, 12th Regional Osteoporosis Conference, Hong Kong. 2011.

Chan K.H., Yeung S.C., Yao T., Ip M.S.M., Cheung A.H.K., Chan M.M.W. and Mak J.C.W., Elevated Plasma Adiponectin Levels In Patients With Chronic Obstructive Pulmonary Disease, Internatioanl Journal Of Tuberculosis And Lung Disease. 2010, 14: 1193-1200.

Han Q., Yeung S.C., Ip M.S.M. and Mak J.C.W., Intermittent hypoxia enhances inflammation and oxidative stress in Eahy926 endothelial cells via suppression of HO-1 expression, American Journal of Respiratory and Critical Care Medicine. 2011, 183: A2475.

Han Q., Yeung S.C., Ip M.S.M. and Mak J.C.W., Intermittent hypoxia enhances oxidative and inflammatory stresses in EAHY926 endothelial cells, Sixth International Symposium of Healthy Aging "A New Golden Age" 5-6 March 2011.

Han Q., Yeung S.C., Ip M.S.M. and Mak J.C.W., Role of HO-1 in intermittent hypoxia-induced inflammation in EAhy926 endothelial cell line, Journal of Pharmacological Sciences. 2011, 115: 158P.

Lau K.W., Chan K.H., Yeung S.C., Ip M.S.M. and Mak J.C.W., Effects of cigarette smoke exposure on serum 5-HT levels in rats, American Journal of Respiratory and Critical Care Medicine. 2011, 183: A2454.

Researcher : Yeung SC

List of Research Outputs

Han Q., Yeung S.C., Ip M.S.M. and Mak J.C.W., Role of HO-1 in intermittent hypoxia-induced inflammation in EAhy926 endothelial cell line, Journal of Pharmacological Sciences. 2011, 115: 158P.

Researcher : Yik PY

List of Research Outputs

Chu L.W., Tam S., Wong L.C., Yik P.Y., Song Y., Cheung B.M.Y., Morley J.E. and Lam K.S.L., Bioavailable Testosterone Predicts a Lower Risk of Alzheimer's Disease in Older Men, J Alzheimers Dis. 2010, 21(4): 1335-1345.

Li Y., Chu L.W., Wang B., Yik P.Y., Huriletemuer I., Jin D., Ma X. and Song Y., Cyp46a1 Functional Promoter Haplotypes Decipher Genetic Susceptibility To Alzheimer's Disease, Journal Of Alzheimer's Disease. IOS Press, 2010, 21(4): 1311-23.

Researcher : Yim ASY

List of Research Outputs

Ma M.K.M., Yung S.S.Y., Yim A.S.Y., Ng K.F., Tang C.S.O., Lui S.L. and Chan D.T.M., Low- versus conventional-level of glucose peritoneal dialysis regimes - comparison of inflammatory and fibrotic mediators in peritoneal dialysate, World Congress of Nephrology 2011.

Researcher : Yip TPS

List of Research Outputs

Gill H., Yip T.P.S., So J.C.C. and Lo W.K., Quiz page October 2010: Anemia in a patient newly transferred from peritoneal dialysis to hemodialysis, Am J Kidney Dis. 2010, 56(4): A37-9.

Yip T.P.S., Tse K.C., Ng F.S.K., Hung I.F.N., Lam M.F., Tang S.C.W., Lui S.L., Lai K.N., Chan D.T.M. and Lo W.K., Clinical course and outcomes of single-organism Enterococcus peritonitis in dialysis patients, Peritoneal Dialysis International. 2011, 31.

Researcher : Yiu CW

List of Research Outputs

Ho W.L., Ho W.M., Zhang W., Yiu C.W., Liu H., Chan K.H., Ramsden D.B. and Ho S.L., Role of mitochondrial uncoupling protein-4 (UCP4) in energy supply during neuronal differentiation, EMBO Meeting 2010, Barcelona, Spain. 2010.

Ho W.M., Ho W.L., Zhang W., Liu H., Kwok H.H., Yiu C.W., Chan K.H., Kung M.H.W., Ramsden D.B. and Ho S.L., Activation of c-Rel mediates neuroprotection via mitochondrial uncoupling protein-4 under NF-kB pathways, EMBO Meeting 2010, Barcelona, Spain (4-7 Sept, 2010). 2010.

Researcher : Yiu KH

List of Research Outputs

Chan Y.H., Lam T.H., Lau K.K., Yiu K.H., Siu D.C.W., Li S.W., Chan H.T., Tam S., Lau C.P. and Tse H.F., Dietary Intake of Phytoestrogen is Associated with Increased Circulating Endothelial Progenitor Cells in Patients with Cardiovascular Disease, European Journal of Cardiovascular Prevention and Rehabilitation. 2010.

Chan Y.H., Lam T.H., Lau G.K.K., Yiu K.H., Siu D.C.W., Li L.S.W., Chan K.H.T., Tam S., Lau C.P. and Tse H.F., Dietary intake of phytoestrogen is associated with increased circulating endothelial progenitor cells in patients with cardiovascular disease, European Journal of Cardiovascular Prevention and Rehabilitation. 2011, 18(3): 360-368.

Lau Y.F., Yiu K.H., Siu D.C.W. and Tse H.F., J Hum Hypertens, Hypertension and atrial fibrillation: Epidemiology, pathophysiology and therapeutic implications. 2011.

Li X., Tse H.F., Yiu K.H., Li L.S.W. and Jin L.J., Effect of periodontal treatment on circulating CD34⁺ cells and peripheral vascular endothelial function: a randomized controlled trial, Journal of Clinical Periodontology. 2011, 38: 148-156.

Mok T.M.Y., Yiu K.H., Wong C.Y., Qiuwaxi J., Lai W.H.K., Wong R.W.S., Tse H.F. and Lau W.C.S., Low circulating level of CD133+KDR+cells in patients with systemic sclerosis., Clinical and Experimental Rheumatology. 2010, 28(5 Suppl 62): S19-25.

Siu D.C.W., Yiu K.H., Lee K.L.F., Yan G., Lee S.W.L., Lau C.P. and Tse H.F., Effects of Right Low Atrial Septal versus Right Atrial Appendage Pacing on Atrial Mechanical Function and Dyssynchrony in Patients with Sinus Node Dysfunction and Paroxysmal Atrial Fibrillation, European Journal of Echocardiography. 2010, 11: 672.

Siu D.C.W., Yiu K.H., Yan G., Yue W., Lee K.L.F., Lee S.W.L., Lau C.P. and Tse H.F., Effects of right low atrial septal versus right atrial appendage pacing on atrial mechanical function and dyssynchrony in patients with sinus node dysfunction and paroxysmal atrial fibrillation, European Society of Echocardiogram. 2010.

Siu D.C.W., Sun N.C.H., Lau T.W., Yiu K.H., Leung F.K.L. and Tse H.F., Siu CW, Sun NC, Lau TW, Yiu KH, Leung F, Tse HF: Preoperative cardiac risk assessment in geriatric patients with hip fractures: an orthopedic surgeons' perspective. , Osteoporos Int. 2010 Dec;21(Suppl 4):S529-34. Epub 2010 Nov 6. 2010.

Tso A.W.K., Lam T.K.Y., Xu A., Yiu K.H., Tse H.F., Li L.S.W., Law S.C., Cheung B.M.Y., Cheung R.T.F. and Lam K.S.L., Serum adipocyte fatty acid-binding protein is associated with ischemic stroke and early death, Neurology. 2011, 76(23): 1968-75.

Wang M.M., Yan G., Yue W., Siu D.C.W., Yiu K.H., Lee S.W.L. and Tse H.F., Left ventricular mechanical dyssynchrony predicts exercise capacity in patients with coronary artery disease and narrow QRS duration, Journal of The American Society of Echocardiography. 2011.

Yiu K.H., Pong V., Siu D.C.W., Lau C.P. and Tse H.F., Cardiovasc Diabetol, Long-term oral nitrate therpy is assoicated with adverse outcome in diabetic patients after elective percutaneous coronary intervention.. 2011, 10(1): 52.

Yiu K.H., Yeung C.K., Chan K.H.T., Wong R.M.Y., Tam S., Lam K.F., Yan G., Yue W., Chan H.H.L. and Tse H.F., Increased arterial stiffness in patients with psoriasis is associated with active systemic inflammation, British Journal of Dermatology. British Association of Dermatologists, 2011, 164: 514-520.

Yiu K.H., Wang S., Mok T.M.Y., Ooi G.C., Khing P.L., Lau C.S. and Tse H.F., J Rheumatol, Relationship between cardiac valvular and arterial calcification in patients with rheumatoid arthritis and systemic lupus erythematosus. 2011, 38: 621-7.

Yiu K.H., Zhang X.H., Tse H.F. and Siu D.C.W., Left ventricular apical akinetic aneurysmatic area associated with permanent right ventricular apical pacing for advanced atrioventricular block: clinical characteristics and long-term outcome. , Europace. . 2011, 13: 514-9.

Yiu K.H., Tse H.F., Mok T.M.Y. and Lau C.S., Nat Rev Rheumatol, Ethnic difference in the cardiovascular risk in patients with rheumatic disease: Focus on Asians. 2011, In Press.

Yiu K.H., Cheung B.M.Y. and Tse H.F., Pharmacological treatment for systolic heart failure. In Lip GY, Tse HF, Oxford: Oxford Univeristy Press. 2011.

Yiu K.H., Wang M.M. and Tse H.F., Stree echocardiography evaluation after percutaneous coronary intervention. In Tintoiu I, Rivard A, P:inte F, Gabriel C, Regar E (eds): , Coronary Stent Restenosis 2011 (in press). 2011.

Yiu Y.F., Chan Y.H., Yiu K.H., Siu D.C.W., Chan H.T., Li S.W., Wong L.Y., Tam S., Lau C.P. and Tse H.F., Vitamin D Deficiency Is Associated With Depletion Of Circulating Endothelial Progenitor Cells And Endothelial Dysfunction In Patients With Type II Diabetes, European Society of Cardiology Annual Congress 2010. European Heart Journal (Supp) 2010 P4690, 2010 . 2010.

Yiu Y.F., Chan Y.H., Yiu K.H., Siu D.C.W., Li L.S.W., Wong L.Y., Lee S.W.L., Tam S., Wong E.W.K., Cheung B.M.Y. and Tse H.F., Vitamin D deficiency is associated with depletion of circulating endothelial progenitor cells and endothelial dysfunction in patients with type 2 diabetes. , J Clin Endocrinol Metab. 2011, 96(5): E830-835.

Researcher : Young JLP

List of Research Outputs

Seto W.K., Lai C.L., Fung J.Y.Y., Hung I.F.N., Yuen J.C.H., Young J.L.P., Wong D.K.H. and Yuen R.M.F., Natural history of chronic hepatitis C: Genotype 1 versus genotype 6, 2010, 53: 444-8.

Seto W.K., Lai C.L., Fung J.Y.Y., Hung I.F.N., Yuen J.C.H., Young J.L.P., Wong D.K.H. and Yuen R.M.F., Natural history of chronic hepatitis C: genotype 1 versus genotype 6., Journal of hepatology : the journal of the European Association for the Study of the Liver. 2010, 53(3): 444-8.

Researcher : Yue W

List of Research Outputs

Ho L.Y., Siu D.C.W., Yue W., Lau C.P., Lip G.Y. and Tse H.F., Safety and efficacy of oral anticoagulation therapy in Chinese patients with concomitant atrial fibrillation and hypertension, Journal of Human Hypertension. 2010, Epub.

Siu D.C.W., Yan G., Yue W., Lee K.L.F., Lee S.W.L., Lau C.P. and Tse H.F., Effects of right low atrial septal versus right atrial appendage pacing on atrial mechanical function and dyssynchrony in patients with sinus node dysfunction and paroxysmal atrial fibrillation , Heart Rhythm. 2011.

Siu D.C.W., Yiu K.H., Yan G., Yue W., Lee K.L.F., Lee S.W.L., Lau C.P. and Tse H.F., Effects of right low atrial septal versus right atrial appendage pacing on atrial mechanical function and dyssynchrony in patients with sinus node dysfunction and paroxysmal atrial fibrillation, European Society of Echocardiogram. 2010.

Siu D.C.W., Lee K.L.F., Yue W., Yan G., Lee S.W.L., Lau C.P. and Tse H.F., Effects of right low atrial septal versus right atrial appendage pacing on strial mechanical function and dyssynchrony in patients with sinus node dysfunction and paroxysmal atrial fibrillation. , Heart Rhythm. 2011.

Wang M.M., Siu D.C.W., Yan G., Yue W., Lee K.L.F., Lee S.W.L., Lau C.P. and Tse H.F., Effects of right low atrial septal versus right atrial appendage pacing on atrial mechanical function and dyssynchrony in patients with sinus node dysfunction and paroxysmal atrial fibrillation , Heart Rhythm. 2011.

Wang M.M., Yan G., Yue W., Siu D.C.W., Yiu K.H., Lee S.W.L. and Tse H.F., Left ventricular mechanical dyssynchrony predicts exercise capacity in patients with coronary artery disease and narrow QRS duration, Journal of The American Society of Echocardiography. 2011.

Yan G., Wang M.M., Yue W., Luk T.H., Dai Y.L.E., Siu D.C.W., Yiu K.H., Lee S.W.L. and Tse H.F., Coenzyme Q10 Supplementation Improves Left Ventricular Torsion In Patients With Ischemic Cardiomyopathy, AHA. 2010.

Yiu K.H., Yeung C.K., Chan K.H.T., Wong R.M.Y., Tam S., Lam K.F., Yan G., Yue W., Chan H.H.L. and Tse H.F., Increased arterial stiffness in patients with psoriasis is associated with active systemic inflammation, British Journal of Dermatology. British Association of Dermatologists, 2011, 164: 514-520.

Yue W., Chong B.H., Zhang X., Liao S., Jim M.H., Kung A.W.C., Tse H.F. and Siu D.C.W., Hyperthyroidism-induced left ventricular diastolic dysfunction: implication in hyperthyroidism-related heart failure, Clin Endocrinol (Oxf). 2011, 74(5): 636-43.

Yue W., Wang M.M., Yan G., Yiu K.H., Yin L.X., Lee S.W.L., Siu D.C.W. and Tse H.F., Smoking is associated with depletion of circulating endothelial progenitor cells and elevated pulmonary artery pressure in patients with coronary artery disease , American Journal of Cardiology . 2010, 2010 Nov 1;106(9):1248-54.

Researcher : Yuen JCH

List of Research Outputs

Fung J.Y.Y., Seto W.K., Lai C.L., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Profiles of HBV DNA in a large population of Chinese patients with chronic hepatitis B: implications for antiviral therapy., Journal of hepatology : the journal of the European Association for the Study of the Liver. 2011, 54: 195-200.

Fung J.Y.Y., Lai C.L., Yuen J.C.H., Cheng C.T.K., Wu C.H., Wong D.K.H., Seto W.K., Hung I.F.N. and Yuen R.M.F., Randomized trial of lamivudine versus entecavir in entecavir-treated patients with undetectable hepatitis B virus DNA: Outcome at 2 years., Hepatology. 2011, 53(4): 1148-53.

Seto W.K., Lai C.L., Fung J.Y.Y., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Elevation of ALT fails to predict significant histologic abnormalities in chronic hepatitis B patients. , Hepatol Int . 2011, 5: 164.

Seto W.K., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Hung I.F.N. and Yuen R.M.F., HBV DNA levels after 12 weeks of telbivudine treatment in chronic hepatitis B predicts long-term outcome., Hepatology . 2010, 52(4 Suppl): 143A.

Seto W.K., Lai C.L., Fung J.Y.Y., Hung I.F.N., Yuen J.C.H., Young J.L.P., Wong D.K.H. and Yuen R.M.F., Natural history of chronic hepatitis C: Genotype 1 versus genotype 6, 2010, 53: 444-8.

Seto W.K., Lai C.L., Fung J.Y.Y., Hung I.F.N., Yuen J.C.H., Young J.L.P., Wong D.K.H. and Yuen R.M.F., Natural history of chronic hepatitis C: genotype 1 versus genotype 6., Journal of hepatology : the journal of the European Association for the Study of the Liver. 2010, 53(3): 444-8.

Seto W.K., Lai C.L., Fung J.Y.Y., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Outcome of 4-year tratemnt of entecavir for treatment-naïve chronic hepatitis B - Poster presentation, 46 ^th Annual Meeting of the European Association for the Study of the Liver - The International Liver Congress™ 2011 in Berlin, Germany between March 30 - April 3. 2011, Abstract No. 748.

Seto W.K., Lai C.L., Fung J.Y.Y., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Outcome of 4-year treatment of entecavir for treatment-naive chronic hepatitis B., J Hepatol . 2011, 54: S301.

Seto W.K., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Hung I.F.N. and Yuen R.M.F., Significance of HBV DNA levels at 12 weeks of telbivudine treatment and the 3 years treatment outcome. {Epub ahead of print], J Hepatol. 2010, 55(3): 522-8.

Yuen R.M.F., Lee C.K., Wong D.K.H., Fung J.Y.Y., Hung I.F.N., Hsu A., But D.Y.K., Cheung T.K., Chan P., Yuen J.C.H., Fung F.K.C., Seto W.K., Lin C.K. and Lai C.L., Prevalence of occult hepatitis B infection in a highly endemicea for chronic hepatitis B: A study of large blood-donor population, GUT. 2010, 59(10): 1389-93.

Yuen R.M.F., Seto W.K., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H. and Lai C.L., Three years of continuous entecavir therapy in treatment-naïve chronic hepatitis B patients: viral suppression, viral resistance and clinical safety. [Epub 2011 Mar 1], Am J Gastroenterol . 2011, 106(7): 1264-71.

Researcher : Yuen MF

Project Title:	An open label study of adefovir dipivoxil for the treatment of patients with chronic hepatitis B (CHB) related advanced fibrosis or cirrhosis
Investigator(s):	Yuen RMF
Department:	Medicine
Source(s) of Funding:	Glaxo Wellcome Hong Kong Ltd. - General Award
Start Date:	07/2005

Project Title:	Randomized, open-label, comparative study to evaluate early viral load reductions and exploratory viral kinetics following administration of entecavir or adefovir in nucleoside-naïve adults with chronic hepatitis B infection
Investigator(s):	Yuen RMF
Department:	Medicine
Source(s) of Funding:	Bristol-Myers-Squibb (HK) - General Award
Start Date:	01/2006

Project Title:	A phase I, multi-centre, randomised, placebo-controlled, dose escalation study to assess the local and systemic tolerability of the therapeutic DNA plasmid pdpSC18 vaccine administered by particle mediated epidermal delivery using the powderject ND 10 delivery system in subjects with chronic hepatitis B infection
Investigator(s):	Yuen RMF
Department:	Medicine
Source(s) of Funding:	PowderMed Ltd - General Award
Start Date:	11/2006

Project Title:	Significance of HBV DNA in the natural history of chronic hepatitis B: impact on disease outcome including significant fibrosis and hepatocellular carcinoma
Investigator(s):	Yuen RMF
Department:	Medicine
Source(s) of Funding:	Bristol-Myers-Squibb (HK) - General Award
Start Date:	09/2007

Project Title:	Transmissibility of hepatitis B virus infection from blood donors with occult hepatitis B infection
Investigator(s):	Yuen RMF, Lai CL, Wong DKH, Yao T
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2008
Completion Date:	11/2010

Project Title:	Virological and clinico-pathological factors in estimating the chance of recurrence of hepatocellular carcinoma after surgical resection in patients with Chronic Hepatitis B
Investigator(s):	Yuen RMF, Hung IFN, Poon RTP, Fong DYT, Wong DKH, Lai CL
Department:	Medicine
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2010

Project Title:	Genetic and epigenetic analyses of occult hepatitis B virus infection
Investigator(s):	Yuen RMF, Fung JYY, Lai CL, Wong DKH, Yao T
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010

Project Title:	Outstanding Researcher Award 2009-10
Investigator(s):	Yuen RMF
Department:	Medicine
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	12/2010

List of Research Outputs

Researcher : Yuen RMF

Project Title:	An open label study of adefovir dipivoxil for the treatment of patients with chronic hepatitis B (CHB) related advanced fibrosis or cirrhosis
Investigator(s):	Yuen RMF
Department:	Medicine
Source(s) of Funding:	Glaxo Wellcome Hong Kong Ltd. - General Award
Start Date:	07/2005

Project Title:	Randomized, open-label, comparative study to evaluate early viral load reductions and exploratory viral kinetics following administration of entecavir or adefovir in nucleoside-naïve adults with chronic hepatitis B infection
Investigator(s):	Yuen RMF
Department:	Medicine
Source(s) of Funding:	Bristol-Myers-Squibb (HK) - General Award
Start Date:	01/2006

Project Title:	A phase I, multi-centre, randomised, placebo-controlled, dose escalation study to assess the local and systemic tolerability of the therapeutic DNA plasmid pdpSC18 vaccine administered by particle mediated epidermal delivery using the powderject ND 10 delivery system in subjects with chronic hepatitis B infection
Investigator(s):	Yuen RMF
Department:	Medicine
Source(s) of Funding:	PowderMed Ltd - General Award
Start Date:	11/2006

Project Title:	Significance of HBV DNA in the natural history of chronic hepatitis B: impact on disease outcome including significant fibrosis and hepatocellular carcinoma
Investigator(s):	Yuen RMF
Department:	Medicine
Source(s) of Funding:	Bristol-Myers-Squibb (HK) - General Award
Start Date:	09/2007

Project Title:	Transmissibility of hepatitis B virus infection from blood donors with occult hepatitis B infection
Investigator(s):	Yuen RMF, Lai CL, Wong DKH, Yao T
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2008
Completion Date:	11/2010

Project Title:	Virological and clinico-pathological factors in estimating the chance of recurrence of hepatocellular carcinoma after surgical resection in patients with Chronic Hepatitis B
Investigator(s):	Yuen RMF, Hung IFN, Poon RTP, Fong DYT, Wong DKH, Lai CL
Department:	Medicine
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2010

Project Title:	Genetic and epigenetic analyses of occult hepatitis B virus infection
Investigator(s):	Yuen RMF, Fung JYY, Lai CL, Wong DKH, Yao T
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010

Project Title:	Outstanding Researcher Award 2009-10
Investigator(s):	Yuen RMF
Department:	Medicine
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	12/2010

List of Research Outputs

But D.Y., Yuen R.M.F., Fung J.Y.Y. and Lai C.L., Safety evaluation of telbivudine., Expert Opin Drug Saf. 2010, 9(5): 821-9.

Feng Y., Siu G.K.Y., Ye X., Wang N., Yuen R.M.F., Leung C.H., Tong Y. and Kobayashi S., Hepatoprotective effects of berberine on carbon tetrachloride-induced acute hepatotoxicity in rats. , Chin Med. 2010, 5: 33.

Fung J.Y.Y., Chan S.C., Yuen R.M.F., Chok K.S.H., Sharr W.W., Fan S.T., Dai J., Seto W.K. and Lo C.M., Entecavir monotherapy is effective in viral suppression after liver transplantation for hepatitis B. , Liver Transpl . 2011, 17(6 Supp 1): S94.

Fung J.Y.Y., Lai C.L., Cheng C.T.K., Wu C.H., Wong D.K.H. and Yuen R.M.F., Mild-to-moderate elevation of alanine aminotransferase increases liver stiffness measurement by transient elastography in patients with chronic hepatitis B. [Epub 2010 Dec 14], Am J Gastroenterol . 2010, 106(3): 492-6.

Fung J.Y.Y., Seto W.K., Lai C.L., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Profiles of HBV DNA in a large population of Chinese patients with chronic hepatitis B: implications for antiviral therapy., Journal of hepatology : the journal of the European Association for the Study of the Liver. 2011, 54: 195-200.

Fung J.Y.Y., Lai C.L., Seto W.K., Wong D.K.H. and Yuen R.M.F., Prognostic significance of liver stiffness for hepatocellular carcinoma and mortality in HBeAg-negative chronic hepatitis B., Journal of Viral Hepatitis. 2010, [Epub ahead of print].

Fung J.Y.Y., Lai C.L., Yuen J.C.H., Cheng C.T.K., Wu C.H., Wong D.K.H., Seto W.K., Hung I.F.N. and Yuen R.M.F., Randomized trial of lamivudine versus entecavir in entecavir-treated patients with undetectable hepatitis B virus DNA: Outcome at 2 years., Hepatology. 2011, 53(4): 1148-53.

Fung J.Y.Y., Lai C.L., But D.Y.K., Hsu A.S.J., Seto W.K., Cheng C.T.K., Wong D.K.H. and Yuen R.M.F., Reduction of liver stiffness following resolution of acute flares of chronic hepatitis B., Hepatol Int . 2010, 4(4): 716-22.

Fung J.Y.Y., Lai C.L., Wong D.K.H., Seto W.K. and Yuen R.M.F., Significant changes in liver stiffness measurement using transient elastography in hepatitis B patients – 3 year follow-up study. , Hepatology. 2010, 52(4 Suppl): 411A.

Fung J.Y.Y., Lai C.L., Wong D.K.H., Seto W.K., Hung I.F.N. and Yuen R.M.F., Significant changes in liver stiffness measurements in patients with chronic hepatitis B: 3 year follow-up study. [Epub 2011 Jan 7], J Viral Hepat . 2011, 18(7): e200-5.

Fung J.Y.Y., Lai C.L., Wong D.K.H., Seto W.K. and Yuen R.M.F., Switching to lamivudine in entecavir-treated patients with undetectable HBV DNA – final results at 96 weeks., Hepatology. 2010, 52(4 Suppl): 144A.

Fung J.Y.Y., Lai C.L., Seto W.K. and Yuen R.M.F., The use of transient elastography in the management of chronic hepatitis B. [Epub ahead of print], Hepatol Int . 2011.

Fung J.Y.Y., Lai C.L. and Yuen R.M.F., To stop or not to stop: The quest for long-term viral suppression., J Gastroenterol Hepatol . 2011, 26(3): 420-2.

Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Updates in the treatment of chronic hepatitis C., Medical Diary. 2010, 15(12): 12-15.

Hsu A.S.J., Lai C.L. and Yuen R.M.F., Update on risk of hepatocellular carcinoma in chronic hepatitis B virus infection. 2011;., Current Hepatitis Reports. 2011, 10(2): 106-111.

Lai C.L., Ahn S.H., Lee K.S., Um S.H., Cho M., Yoon S.K., Lee J.W., Park N.W., Kwon Y.O., Sohn J.H., Lee J.Y., Park H.E., Kim J.A., Han K.H. and Yuen R.M.F., A phase IIB study of the efficacy and safety of LB80380 vs entecavir in treatkent-naïve patients with chronic hepatitis B, 46^th Annual Meeting of the European Association for the Study of the Liver (EASL) - The International Liver Congress 2011 in Berlin, Germany between March 30 - April 3. 2011, Abstract No. 1353.

Lai C.L. and Yuen R.M.F., Management of chronic hepatitis B., In: In Chen CW, Cheng J, Gines P, Quyang Q, Scholmerich J eds, Gut and Liver. Falk Symposium 174. Basel, Karger, 2011, 95-101.

Lai C.L., Ahn S.H., Lee K.S., Um S.H., Cho M., Yoon S.K., Lee J.W., Park N.W., Kwon Y.O., Sohn J.H., Lee J.Y., Park H.E., Kim J.A., Han K.H. and Yuen R.M.F., Oral presentation "A phase IIb study of the efficacy and safety of LB80380 vs entecavir in treatment-naive patients with chronic hepatitis B", Journal of hepatology : the journal of the European Association for the Study of the Liver. 2011, 54 Suppl 1: S535.

Lai C.L. and Yuen R.M.F., Systemic corticosteroid and reactivation of chronic hepatitis B., Respiratory . 2010, 15(7): 1017-8.

Lam C.L.K., Lam T.P., Lai C.L., Yuen R.M.F., Fong D.Y.T., McGhee S. and Leung G.M., Health-related Quality of Life and Health Preference of Patients with Chronic Hepatitis B Infections, Poster presented at the Health Research Symposium 2010 in Hong Kong on Sept 11, 2010. Hong Kong.

Lo C.L.R., Tung K.K., Mak K.M., Fatima S., Zhou H., Poon R.T.P., Yuen R.M.F., Lai C.L., Li J., Luk J.M.C. and Ng I.O.L., Both tissue and serum dickkopf-1 (DKK-1) levels have clincopathologic and prognostic significance in hepatocellular carcinoma., Hepatology . 2010, 52(4 Suppl): 282A.

Seto W.K., Lai C.L., Fung J.Y.Y., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Elevation of ALT fails to predict significant histologic abnormalities in chronic hepatitis B patients. , Hepatol Int . 2011, 5: 164.

Seto W.K., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Hung I.F.N. and Yuen R.M.F., HBV DNA levels after 12 weeks of telbivudine treatment in chronic hepatitis B predicts long-term outcome., Hepatology . 2010, 52(4 Suppl): 143A.

Seto W.K., Ng M.M.T., Chan P., Ng I.O.L., Cheung S.C.W., Hung I.F.N., Yuen R.M.F. and Lai C.L., Ketamine-induced cholangiopathy: a case report., Am J Gastroenterol. 2011, 106(5): 1004-5.

Seto W.K., Lai C.L., Fung J.Y.Y. and Yuen R.M.F., Lamivudine therapy for chronic hepatitis B., Ann Gastroenterol Hepatol. 2010, 1(1): 63-70.

Seto W.K., Lai C.L., Fung J.Y.Y., Hung I.F.N., Yuen J.C.H., Young J.L.P., Wong D.K.H. and Yuen R.M.F., Natural history of chronic hepatitis C: Genotype 1 versus genotype 6, 2010, 53: 444-8.

Seto W.K., Lai C.L., Fung J.Y.Y., Hung I.F.N., Yuen J.C.H., Young J.L.P., Wong D.K.H. and Yuen R.M.F., Natural history of chronic hepatitis C: genotype 1 versus genotype 6., Journal of hepatology : the journal of the European Association for the Study of the Liver. 2010, 53(3): 444-8.

Seto W.K., Lai C.L., Fung J.Y.Y., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Outcome of 4-year tratemnt of entecavir for treatment-naïve chronic hepatitis B - Poster presentation, 46 ^th Annual Meeting of the European Association for the Study of the Liver - The International Liver Congress™ 2011 in Berlin, Germany between March 30 - April 3. 2011, Abstract No. 748.

Seto W.K., Lai C.L., Fung J.Y.Y., Yuen J.C.H., Wong D.K.H. and Yuen R.M.F., Outcome of 4-year treatment of entecavir for treatment-naive chronic hepatitis B., J Hepatol . 2011, 54: S301.

Seto W.K., Lai C.L., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Hung I.F.N. and Yuen R.M.F., Significance of HBV DNA levels at 12 weeks of telbivudine treatment and the 3 years treatment outcome. {Epub ahead of print], J Hepatol. 2010, 55(3): 522-8.

Seto W.K., Yuen R.M.F., Fung J.Y.Y. and Lai C.L., Tenofovir disoproxil fumarate in the treatment of chronic hepatitis B. [Epub ahead of print], Hepatol Int. 2011.

Seto W.K., Tanaka Y., Liu K., Lai C.L. and Yuen R.M.F., The effects of IL-28B and ITPA polymorphisms on treatment of hepatitis B virus genotype 6. , Am J Gastroenterol . 2011, 106(5): 1007-8.

Tang L., Pu Y., Wong D.K.H., Liu T., Tang H., Xiang T., Yuen R.M.F. and Ren G., The hepatitis B virus-associated estrogen receptor alpha (ER{alpha}) was regulated by microRNA-130a in HepG2.2.15 human hepatocellular carcinoma cells. [Epub ahead of print], Acta Biochim Biophys Sin . 2011.

Wong D.K.H., Lai C.L., Seto W.K., Fung J.Y.Y., Huang F.Y., Hung I.F.N. and Yuen R.M.F., Efficacies of one year nucleos(t)ide analogue therapy in intrahepatic HBV DNA and covalently closed circular DNA reduction. , J Hepatol (Poster presentation at the 46th Annual Meeting of EASL, Berlin, March 30 - April 3, 2011).. 2011, 54: S303.

Wong D.K.H., Huang F.Y., Poon R.T.P., Lai C.L., Fung J.Y.Y., Seto W.K., Hung I.F.N. and Yuen R.M.F., HBV replicative activity in patients with cryptogenic cause of hepatocellular carcinoma, Hepatology. 2010, 52: 247A.

Yang H.I., Yuen R.M.F., Chan H.L.Y., Han K.H., Chen P.J., Kim D.Y., Ahn S.H., Chen C.J., Wong V.W.S. and Seto W.K., Risk estimation for hepatocellular carcinoma in chronic hepatitis B (REACH-B): development and validation of a predictive score. Epub 2011 Apr 14, Lancet Oncology. 2011, 12 (6): 568-74.

Yap D.Y.H., Tang C.S.O., Yung S.S.Y., Choy C.B.Y., Yuen R.M.F. and Chan D.T.M., Long-term outcome of renal transplant recipients with chronic hepatitis B infection - impact of antiviral treatments, Transplantation. 2010, 90(3): 325-330.

Yeung P., Wong D.K.H., Lai C.L., Fung J.Y.Y., Seto W.K. and Yuen R.M.F., Association of Hepatitis B Virus Pre-S Deletions with the Development of Hepatocellular Carcinoma in Chronic Hepatitis B, Journal of Infectious Diseases. 2011, 203: 646-54.

Yeung P., Wong D.K.H., Lai C.L., Fung J.Y.Y., Seto W.K. and Yuen R.M.F., Association of hepatitis B virus pre-S deletions with the development of hepatocellular carcinoma in chronic hepatitis B. 2011;, J Infect Dis . 2011, 203(5): 646-54.

Yeung P., Wong D.K.H., Lai C.L., Fung J.Y.Y., Seto W.K. and Yuen R.M.F., Profile of pre-S deletions in the natural history of chronic hepatitis B infection, Journal of Medical Virology. 2010, 82: 1843-9.

Yeung P., Wong D.K.H., Lai C.L., Fung J.Y.Y., Seto W.K. and Yuen R.M.F., Profile of pre-S deletions in the natural history of chronic hepatitis B. 2010;, J Med Virol . 2010, 82(11): 1843-9.

Yuen R.M.F., Asia experience in chronic hepatitis B management., 4th Ditan International Conference on Infectious Diseases, Beijing, China, 15 – 18 July 2010.. 2010.

Yuen R.M.F., Factors associated with disease progression in chronic hepatitis B – implication for treatment., The 21st Annual Conference of the Asian Pacific Association for the Study of the Liver (APASL), Bangkok, Thailand, 17-20 February 2011.. 2011.

Yuen R.M.F., Factors to consider for starting treatment for HBV., Asian Pacific Digestive Week, Kuala Lumpur, Malaysia 19 – 22 September 2010. 2010.

Yuen R.M.F., Factors to consider for starting treatment for chronic hepatitis B. , 23rd international symposium on Hepatology, 23rd annual scientific meeting. The Hong Kong Association for the Study of Liver Diseases, Hong Kong, 21st November 2010.. 2010.

Yuen R.M.F., Faculty Teaching Medal 2010, Faculty of Medicine, The University of Hong Kong. 2011.

Yuen R.M.F., From clinical trials to real life experience: Hong Kong real world entecavir data. Management of chronic hepatitis B: lessens learned. , 2011 APASL BMS Taiwan/ Hong Kong closed door meeting, Bangkok, Thailand, 18th February 2011.. 2011.

Yuen R.M.F., Hepatitis B/ C Asian experience: epidemiology and treatment. , Liver Fibrosis Expert Panel Meeting, Hong Kong 2-3 September 2010. 2010.

Yuen R.M.F., Hepatology International , 2010.

Yuen R.M.F., Hypothetical case studies. , FACE B Speaker Training Meeting for Hepatologists in USA, Boston, USA, 2 Nov 2010.. 2010.

Yuen R.M.F., Key real-world data: Europe and Asia. From viral suppression to disease regression? The importance of long-term CHB management. , The 21st Annual Conference of the Asian Pacific Association for the Study of the Liver (APASL), Bangkok, Thailand, 17-20 February 2011.. 2011.

Yuen R.M.F., Long term responses with telbivudine: a local analysis., Scientific Symposium, The Hong Kong Association for the Study of Liver Diseases, Hong Kong 6th July 2010.. 2010.

Yuen R.M.F., Occult hepatitis B infection: A disease of concern? , Frontiers in Biomedical Research, The University of Hong Kong, Hong Kong 3 December 2010.. 2010.

Yuen R.M.F., One therapy from day one., US speaker program tour, Boston(3 November 2010), Conneticut(3 November 2010), New York(4 & 5 November 2010), USA, 3 – 5 November 2010.. 2010.

Yuen R.M.F., Outstanding Research Award 2009-2010, The University of Hong Kong. 2010.

Yuen R.M.F., Plos One, 2010.

Yuen R.M.F., Predictors of mortality in acute-on-chronic liver failure. APASL working party on acute on chronic liver failure. , Liver-data share and consensus development meeting, Bangkok, Thailand, 20th February 2011.. 2011.

Yuen R.M.F., Lee C.K., Wong D.K.H., Fung J.Y.Y., Hung I.F.N., Hsu A., But D.Y.K., Cheung T.K., Chan P., Yuen J.C.H., Fung F.K.C., Seto W.K., Lin C.K. and Lai C.L., Prevalence of occult hepatitis B infection in a highly endemicea for chronic hepatitis B: A study of large blood-donor population, GUT. 2010, 59(10): 1389-93.

Yuen R.M.F., Real life experience: Hong Kong cohort of entecavir treatment. , Regional Meeting on Management of chronic hepatitis B Patients, the Liver Society of Thailand, Chiangrai, Thailand, 4-5 December 2010.. 2010.

Yuen R.M.F., The epidemiology of hepatitis B and C and current approaches to control and prevention and their impact. , World Cancer Congress, International Union Against Cancer, Shenzhen, China 18-21 August 2010.. 2010.

Yuen R.M.F., Seto W.K., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H. and Lai C.L., Three years of continuous entecavir therapy in treatment-naïve chronic hepatitis B patients: viral suppression, viral resistance and clinical safety. [Epub 2011 Mar 1], Am J Gastroenterol . 2011, 106(7): 1264-71.

Yuen R.M.F., Wong D.K.H., Lee C.K., Tanaka Y., Allain J.P., Fung J.Y.Y., Leung J., Lin C.K., Sugiyama M., Sugauchi F., Mizokami M. and Lai C.L., Transmissibility of hepatitis B virus (HBV) infection through blood transfusion from blood donors with occult hepatitis B virus infection. [Epub 2011 Jan 18], Clin Infect Dis. 2011, 52(5): 624-32.

Yuen R.M.F. and Lai C.L., Treatment of chronic hepatitis B: Evolution over two decades., Journal of Gastroenterology and Hepatology. 2011, 26 Suppl 1: 138-43.

Yuen R.M.F. and Lai C.L., Treatment of chronic hepatitis B: evolution over two decades. , J Gastroenterol Hepatol . 2011, 26 (Suppl 1): 138-43.

Zhu M., Wang N., Tsao G.S.W., Yuen R.M.F., Feng Y.G., Wan T.S.K., Man K. and Feng Y., Up-regulation of microRNAs, miR21 and miR23a, in human liver cancer cells treated with Coptidis Rhizome aqueous extract, Experimental and Therapeutic Medicine. 2011.

Researcher : Yung PM

List of Research Outputs

Ip K.M., Yung P.M., Chan D.T.M. and Wong A.S.T., Hepatocyte growth factor modulates adhesion of ovarian cancer cells to the peritoneum mesothelium through p70 S6 kinase, 102th Annual Meeting of the American Association for Cancer Research, Orlando, FL (Abstract No. 1527). 2011.

Lam C.L.D., Fu K.H., Lui M.M.S., Yung P.M., Cheung A.H.K., Lam W.K., Wistuba I.I., Tsao G.S.W., Ip M.S.M. and Minna J.D., Expression of nicotinic acetylcholine receptor in human bronchial epithelium in relation to airflow obstruction, American Thoracic Society Annual Meeting 2011.

Researcher : Yung SSY

Project Title:	Role of high and low molecular weight hyaluronan in the pathogenesis of lupus nephritis
Investigator(s):	Yung SSY, Chan DTM
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2009

Project Title:	The role of Pseudomonas aeruginosa in mediating inflammatory and fibrotic processes in human peritoneal mesothelial cells - implications in peritoneal dialysis.
Investigator(s):	Yung SSY, Chan DTM
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2009
Completion Date:	02/2011

Project Title:	The role of decorin in peritoneal inflammation and fibrosis
Investigator(s):	Yung SSY, Chan DTM
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010

Project Title:	The effect of heparin on inflammatory and fibrotic processes in human mesothelial cells during peritoneal dialysis
Investigator(s):	Yung SSY, Chan DTM
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2010

Project Title:	43rd Annual Meeting and Scientific Exposition of the American Society of Nephrology Anti-dsDNA Antibodies from Patients with Lupus Nephritis Bind to Annexin II on Human Mesangial Cells
Investigator(s):	Yung SSY
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	11/2010
Completion Date:	11/2010

Project Title:	The role of TGF-beta1 and phosphatidylinositol 3-kinase activation on perlecan synthesis in mesangial cells
Investigator(s):	Yung SSY, Chan DTM
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2011

List of Research Outputs

Chan D.T.M., Zhang C., Chau K.M. and Yung S.S.Y., Comparison of mycophenolate mofetil and rapamycin on inflammatory and fibrotic mediators in NZB/W mice with active disease, Journal of the American Society of Nephrology. 2010, 21: 753A.

Chan D.T.M., Zhang C., Chau K.M. and Yung S.S.Y., Effects of mycophenolate mofetil and rapamycin on inflammatory and fibrotic mediators in NZB/W mice with active nephritis, World Congress of Nephrology 2011.

Ma M.K.M., Yung S.S.Y., Yim A.S.Y., Ng K.F., Tang C.S.O., Lui S.L. and Chan D.T.M., Low- versus conventional-level of glucose peritoneal dialysis regimes - comparison of inflammatory and fibrotic mediators in peritoneal dialysate, World Congress of Nephrology 2011.

Tan K.C.B., Wang Y., Shiu S.W.M., Wong Y., Yung S.S.Y. and Chan D.T.M., Adenosine triphosphate binding cassette transporter G1-mediated cholesterol efflux to serum is impaired in type 2 diabetes mellitus, American Diabetes Association 71st Scientific Sessions, San Diego, USA. San Diego, USA, 2011.

Yap D.Y.H., Tang C.S.O., Yung S.S.Y., Choy C.B.Y., Yuen R.M.F. and Chan D.T.M., Long-term outcome of renal transplant recipients with chronic hepatitis B infection - impact of antiviral treatments, Transplantation. 2010, 90(3): 325-330.

Yung S.S.Y., Cheung K.F., Zhang Q. and Chan D.T.M., Anti-dsDNA antibodies bind to mesangial annexin II in lupus nephritis. 2010 Nov;21(11):1912-27., Journal of American Society of Nephrology. 2010, 21: 1912-17.

Yung S.S.Y., Cheung K.F., Zhang Q. and Chan D.T.M., Anti-dsDNA antibodies from patients with lupus nephritis bind to annexin II on human mesangial cells, Journal of the American Society of Nephrology. 2010, 21: 755A.

Yung S.S.Y., Mesothelial Cells, The 13th Congress of the International Society for Peritoneal Dialysis. 2010.

Researcher : Zhang C

List of Research Outputs

Chan D.T.M., Zhang C., Chau K.M. and Yung S.S.Y., Comparison of mycophenolate mofetil and rapamycin on inflammatory and fibrotic mediators in NZB/W mice with active disease, Journal of the American Society of Nephrology. 2010, 21: 753A.

Chan D.T.M., Zhang C., Chau K.M. and Yung S.S.Y., Effects of mycophenolate mofetil and rapamycin on inflammatory and fibrotic mediators in NZB/W mice with active nephritis, World Congress of Nephrology 2011.

Researcher : Zhang C

List of Research Outputs

Researcher : Zhang J

List of Research Outputs

Yu H., Xia F., Lam K.S.L., Wang Y., Bao Y., Zhang J., Gu Y., Zhou P., Lu J., Jai W. and Xu A., Circadian Rhythm of Circulating Fibroblast Growth Factor 21 (FGF21) is Related to Diurnal Changes in Free Fatty Acids in Humans., Clinical Chemistry. 2011.

Zhang J., Chan Y.C., Ho J.C.Y., Siu D.C.W., Lian Q. and Tse H.F., Proliferation of Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells via Ether à go-go 1 (hEAG1) Potassium Channel., Journal of Cellular and Molecular Medicine (Under Review). 2011.

Researcher : Zhang J

List of Research Outputs

Researcher : Zhang Q

List of Research Outputs

Yung S.S.Y., Cheung K.F., Zhang Q. and Chan D.T.M., Anti-dsDNA antibodies bind to mesangial annexin II in lupus nephritis. 2010 Nov;21(11):1912-27., Journal of American Society of Nephrology. 2010, 21: 1912-17.

Yung S.S.Y., Cheung K.F., Zhang Q. and Chan D.T.M., Anti-dsDNA antibodies from patients with lupus nephritis bind to annexin II on human mesangial cells, Journal of the American Society of Nephrology. 2010, 21: 755A.

Researcher : Zhang R

List of Research Outputs

Zou B., Chim J.C.S., Pang R.W.C., Zeng H.U.I., Dai Y., Zhang R., Lam S.C., Tan V.P.Y., Hung I.F.N. and Lan H.Y., XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification, Mol Carcinog. 2011.

Zou B., Chim J.C.S., Pang R.W.C., Zeng H.U.I., Dai Y., Zhang R., Lam S.C., Tan V.P.Y., Hung I.F.N., Lan H.Y. and Wong B.C.Y., XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification, Molecular Carcinogenesis. 2010, under review.

Researcher : Zhang W

List of Research Outputs

Ho W.L., Ho W.M., Zhang W., Yiu C.W., Liu H., Chan K.H., Ramsden D.B. and Ho S.L., Role of mitochondrial uncoupling protein-4 (UCP4) in energy supply during neuronal differentiation, EMBO Meeting 2010, Barcelona, Spain. 2010.

Ho W.M., Ho W.L., Zhang W., Liu H., Kwok H.H., Yiu C.W., Chan K.H., Kung M.H.W., Ramsden D.B. and Ho S.L., Activation of c-Rel mediates neuroprotection via mitochondrial uncoupling protein-4 under NF-kB pathways, EMBO Meeting 2010, Barcelona, Spain (4-7 Sept, 2010). 2010.

Ma J., Wang J., Zhang W., Zou B., Chen W., Lam S.C., Chen M., Pang R.W.C., Tan V.P.Y., Hung I.F.N., Lan H.Y., Wang Q. and Wong B.C.Y., Promoter hypermethylation and histone hypoacetylation contribute to Pancreatic-duodenal homeobox 1 (PDX1) silencing in gastric cancer., Carcinogenesis. 2010, 31(9): 1552-60.

Zhang W., Jiang B., Guo Z., Sardet C., Zou B., Lam S.C., Li J., He M., Lan H.Y., Pang R.W.C., Hung I.F.N., Tan V.P.Y., Wang J. and Wong B.C.Y., Four-and-a-half LIM protein 2 promotes invasive potential and epithelial-mesenchymal transition in colon cancer., Carcinogenesis. 2010, 31: 1220-9.

Researcher : Zhang W

List of Research Outputs

Researcher : Zhang W.

List of Research Outputs

Zhang W..., Wang J..., Zou B..., Sardet C..., Li J..., Lam S...C..., Ng L..., Pang R...W...C..., Hung I...F...N..., Tan V...P...Y..., Jiang B... and Wong B...C...Y..., Four and a half LIM protein 2 (FHL2) negatively regulates the transcription of E-cadherin through interaction with Snail1, European Journal of Cancer. 2011, 47(1): 121-130.

Zhang W..., Yang Y..., Jiang B..., Peng J., Tu S..., Sardet C..., Zhang Y..., Pang R...W...C..., Hung I...F...N..., Tan V...P...Y..., Lam S...C..., Wang J... and Wong B...C...Y..., XIAP-associated factor 1 interacts with and attenuates the trans-activity of four and a half LIM protein 2, Molecular Carcinogenesis. 2010, 50: 199-207.

Researcher : Zhang X

List of Research Outputs

Yue W., Chong B.H., Zhang X., Liao S., Jim M.H., Kung A.W.C., Tse H.F. and Siu D.C.W., Hyperthyroidism-induced left ventricular diastolic dysfunction: implication in hyperthyroidism-related heart failure, Clin Endocrinol (Oxf). 2011, 74(5): 636-43.

Zhang X., Jin M., Sun H., Zhang S. and Li G.R., The calmodulin inhibitor N-(6-aminohexyl)-5-chloro-1-naphthalene sulphonamide directly blocks human ether à-go-go-related gene potassium channels stably expressed in human embryonic kidney 293 cells., Br J Pharmacol. 2010, 161(4): 872-884.

Researcher : Zhang X

List of Research Outputs

Researcher : Zhang Y

List of Research Outputs

Liao S., Liu Y., Siu D.C.W., Zhang Y., Lai K.W.H., Au K.W., Lee Y.K., Li R.A. and Tse H.F., Proarrhythmic risk of embryonic stem cell-derived cardiomyocyte transplantation in infarcted myocardium, Heart Rhythm. 2010, 7(12): 1852-9.

Zhang Y., Tao R. and Li G., Both ion channels and calcium signals regulate proliferation in human adult mesenchymal stem cells from bone marrow, ISSCR 9th Annual Meeting. June 2011. Metro Toronto Convention Centre, TORONTO, Canada. 2011, 156.

Zhang Y., Lau C.P., Tse H.F. and Li G.R., Expression of TrpC and TrpM channels in human atrial myocytes, J HK Coll Cardiol. 2010. 18(2): 71.

Zhang Y., Lau C.P. and Li G., Human cardiac Kv4.3 channels are regulated by EGFR kinase and Src-family kinases., International Academy of Cardiology 15th World Congress on Heart Disease Annual Scientific Sessions, Vancouver, BC, Canada; July 24-27, 2010.. 2010.

Zhang Y., Sun H., Tse H.F., Lau C.P. and Li G.R., Identification of transient receptor potential channels in human atrial myocytes, 16th Medical Research Conference, Department of Medicine, HKU. 2011, 17(1): 68.

Researcher : Zhang Y

List of Research Outputs

Zhang Y., Lau C.P., Tse H.F. and Li G.R., Expression of TrpC and TrpM channels in human atrial myocytes, J HK Coll Cardiol. 2010. 18(2): 71.

Researcher : Zhang Y

List of Research Outputs

Zhang Y., Lau C.P., Tse H.F. and Li G.R., Expression of TrpC and TrpM channels in human atrial myocytes, J HK Coll Cardiol. 2010. 18(2): 71.

Researcher : Zhang Y.

List of Research Outputs

Zhang W..., Yang Y..., Jiang B..., Peng J., Tu S..., Sardet C..., Zhang Y..., Pang R...W...C..., Hung I...F...N..., Tan V...P...Y..., Lam S...C..., Wang J... and Wong B...C...Y..., XIAP-associated factor 1 interacts with and attenuates the trans-activity of four and a half LIM protein 2, Molecular Carcinogenesis. 2010, 50: 199-207.

Researcher : Zhou L

List of Research Outputs

Zhou L., Chu L.W., Kwan S.C., Lam K.S.L., Ho W.L., Ho W.M. and Chan K.H., Plasma amyloid beta peptides and oligomers antibodies in Alzheimer's disease, 16th Medical Research Conference, Department of Medicine, The University of Hong Kong, 2011. Hong Kong Medical Journal . 2011, 17 (Supplement 1): 69.

Zhou L., Chu L.W., Kwan S.C., Lam K.S.L., Ho W.L., Ho W.M. and Chan K.H., Plasma amyloid beta peptides and oligomers levels in Alzheimer's disease, 16th Medical Research Conference, Department of Medicine, The University of Hong Kong, 2011. Hong Kong Medical Journal. 2011, 17 (Supplement 1): 69.

Zhou L., Chu L.W., Kwan S.C., Lam K.S.L., Ho W.L., Ho W.M. and Chan K.H., Plasma beta-amyloid peptides and serum associated beta-amyloid autoantibodies in patients with Alzheimer's disease, Alzheimer's Disease Conference 2011: From Public Health, Basci And Clinical Sciences To Therapeutic Insights. 2011.

Zhou L., Chu L.W., Kwan S.C., Lam K.S.L., Ho W.L., Ho W.M. and Chan K.H., Plasma b-amyloid Peptides And Serum Associated b-amyloid Autoantibodies In Alzheimer's Disease, Sixth International Symposium On Healthy Aging. 2011.

Researcher : Zhou P

List of Research Outputs

Yu H., Xia F., Lam K.S.L., Wang Y., Bao Y., Zhang J., Gu Y., Zhou P., Lu J., Jai W. and Xu A., Circadian Rhythm of Circulating Fibroblast Growth Factor 21 (FGF21) is Related to Diurnal Changes in Free Fatty Acids in Humans., Clinical Chemistry. 2011.

Researcher : Zhu W

List of Research Outputs

Cheng K.Y., Lam K.S.L., Wang Y., Zhu W., Hoo R.L.C. and Xu A., Transgenic over-expression of APPL1 improves high-fat diet-induced insulin resistance in liver and skeletal muscle., Sixth International Symposium on Healthy Aging: " A New Golden Age”. 2011.. 2011.

Cheng K.Y., Lam K.S.L., Wang Y., Zhu W. and Xu A., Ubiquitination Is Indispensible For The Insulin-sensitizing Activity Of The Adaptor Protein Appl1. 16th Medical Research Conference. , 16th Medical Research Conference 2011. The University of Hong Kong. 2011.

Cheng K.Y., Lam K.S.L., Chen B., Zhu W., Wang Y. and Xu A., 銜接蛋白質APPL1和APPL2對島素敏感性和葡萄糖代謝的陰陽調控 - 從分子機制到生理作用, 2011.

Zhu W., Cheng K.Y., Chen B., Wang Y., Lam K.S.L. and Xu A., APPL2 inhibits insulin-stimulated glucose uptake through both Akt and its downstream target TBC1D1 in skeletal muscle, 16th Medical Research Conference. The University of Hong Kong, Hong Kong. . 2011.

Researcher : Zou B

List of Research Outputs

Ma J., Wang J., Zhang W., Zou B., Chen W., Lam S.C., Chen M., Pang R.W.C., Tan V.P.Y., Hung I.F.N., Lan H.Y., Wang Q. and Wong B.C.Y., Promoter hypermethylation and histone hypoacetylation contribute to Pancreatic-duodenal homeobox 1 (PDX1) silencing in gastric cancer., Carcinogenesis. 2010, 31(9): 1552-60.

Zhang W., Jiang B., Guo Z., Sardet C., Zou B., Lam S.C., Li J., He M., Lan H.Y., Pang R.W.C., Hung I.F.N., Tan V.P.Y., Wang J. and Wong B.C.Y., Four-and-a-half LIM protein 2 promotes invasive potential and epithelial-mesenchymal transition in colon cancer., Carcinogenesis. 2010, 31: 1220-9.

Zou B., Chim J.C.S., Pang R.W.C., Zeng H.U.I., Dai Y., Zhang R., Lam S.C., Tan V.P.Y., Hung I.F.N. and Lan H.Y., XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification, Mol Carcinog. 2011.

Zou B., Chim J.C.S., Pang R.W.C., Zeng H.U.I., Dai Y., Zhang R., Lam S.C., Tan V.P.Y., Hung I.F.N., Lan H.Y. and Wong B.C.Y., XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification, Molecular Carcinogenesis. 2010, under review.

Researcher : Zou B.

List of Research Outputs

Zhang W..., Wang J..., Zou B..., Sardet C..., Li J..., Lam S...C..., Ng L..., Pang R...W...C..., Hung I...F...N..., Tan V...P...Y..., Jiang B... and Wong B...C...Y..., Four and a half LIM protein 2 (FHL2) negatively regulates the transcription of E-cadherin through interaction with Snail1, European Journal of Cancer. 2011, 47(1): 121-130.

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