DEPT OF MICROBIOLOGY
| Researcher : Ahmed SS |
| List of Research Outputs |
| Lau S.K.P., Li K.S.M., Tsang K.L., Lam S.F., Ahmed S.S., Chen H., Chan K.H., Woo P.C.Y. and Yuen K.Y., Genetic Characterization of Betacoronavirus Lineage C Viruses in Bats Reveals Marked Sequence Divergence in the Spike Protein of Pipistrellus Bat Coronavirus HKU5 in Japanese Pipistrelle: Implications for the Origin of the Novel Middle East Respiratory Syndrome Coronavirus, Journal of Virology. 2013, 87: 8638-8650. |
| Researcher : BAI R |
| List of Research Outputs |
| Lau S.K.P., Woo P.C.Y., Yip C.Y., BAI R., WU Y., Tse H. and Yuen K.Y., Complete genome sequence of a novel feline astrovirus from domestic cat in Hong Kong, Genome Announcements . 2013, 1: e00708-13. |
| Woo P.C.Y., Lau S.K.P., Teng L.L., Tsang K.L., Joseph M., Wong Y.M., TANG Y., Sivakumar S., Xie J., BAI R., Wernery R., Wernery U. and Yuen K.Y., New hepatitis E virus genotype in camel, the Middle East, Emerging Infectious Diseases . 2014, 20: 1044-1048. |
| Researcher : CHAN SYJ |
| List of Research Outputs |
| Lau S.K.P., Tse H., CHAN S.Y.J., Zhou A.C., Curreem S.O.T., Lau C.Y., Yuen K.Y. and Woo P.C.Y., Proteome profiling of the dimorphic fungus Penicillium marneffei extracellular proteins and identification of glyceraldehyde-3-phosphate dehydrogenase as an important adhesion factor for conidial attachment, FEBS Journal . 2013, 280: 6613-6626. |
| Researcher : CHEN C |
| List of Research Outputs |
| CHEN C., ZHANG Y., ZHANG Y., Li J., Tsao G.S.W. and Zhang M., Superior Antitumor Activity of a Novel Bispecific Antibody Cotargeting Human Epidermal Growth Factor Receptor 2 and Type I Insulin-like Growth Factor Receptor, Molecular Cancer Therapeutics. 2013, 13: 90-100. |
| Researcher : CHEUNG YY |
| List of Research Outputs |
| Ho P.L., CHEUNG Y.Y., Lo W.U., LI Z., Chow K.H., Lin C., Chan J.F.W. and Cheng V.C.C., Molecular Characterization of an Atypical IncX3 Plasmid pKPC-NY79 Carrying bla KPC-2 in a Klebsiella pneumoniae. , Current Microbiology. 2013. |
| Ho P.L., Chan J., Lo W.U., Lai E.L.Y., CHEUNG Y.Y., Terrence L.A.U. and Chow K.H., Prevalence and molecular epidemiology of plasmid-mediated fosfomycin resistance genes among blood and urinary Escherichia coli isolates, J Med Microbiol. UK, 2013, 62: 1707-1713. |
| Ho P.L., Lo W.U., Chan J., CHEUNG Y.Y., Chow K.H., Yam W.C., Lin C. and Que T.L., pIMP-PH114 carrying bla IMP-4 in a Klebsiella pneumoniae strain is closely related to other multidrug-resistant IncA/C2 plasmids., Current Microbiology. Springer US, 2014, 68(2): 227-232. |
| Lo W.U., Chow K.H., LAW Y.T., NG K.Y., CHEUNG Y.Y., Lai E.L.Y. and Ho P.L., Highly conjugative IncX4 plasmids carrying blaCTX-M in Escherichia coli from human and food animals. , Journal of medical microbiology. United Kingdom, 2014, 63: 835-40. |
| Researcher : Cai J |
| List of Research Outputs |
| HUA Y., Zhang B., Liu C.Y., Cai J. and Huang J., Development of a Virosome Vaccine against Aspergillus Fumigatus , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013.. 2013. |
| Lau S.K.P., Woo P.C.Y., WU Y., WONG Y.P., Wong B.H.L., Lau C.Y., Fan Y.Y., Cai J., Tsoi H.W., Chan K.H. and Yuen K.Y., Identification and characterization of a novel paramyxovirus, porcine parainfluenza 1 virus, from deceased pigs, Journal of General Virology. 2013, 94: 2184-2190. |
| Woo P.C.Y., Lau S.K.P., Wernery U., Wong Y.M., Tsang K.L., Johnson B., Yip C.Y., Lau C.Y., Sivakumar S., Cai J., Fan Y.Y., Chan K.H., Mareena R. and Yuen K.Y., Novel betacoronavirus in dromedaries of the Middle East, 2013, Emerging Infectious Diseases. 2014, 20: 560-572. |
| Researcher : Chan CM |
| List of Research Outputs |
| Yang E., Wang G., Woo P.C.Y., Lau S.K.P., Chow W.N., Chong T.K., Tse H., Kao R.Y.T., Chan C.M., Che X., Yuen K.Y. and Cai J.J., Unraveling the molecular basis of temperature-dependent genetic regulation in Penicillium marneffei, Eukaryotic Cell . 2013, 12: 1214-1224. |
| Researcher : Chan CS |
| List of Research Outputs |
| ZHANG N., LIN Y., Chen M., LEUNG H.C., Chan C.S., Poon K.M., Zhou J., Cheung C.Y., Lu L. and Zheng B., Pandemic A/H1N1 2009 Influenza Virus-like Particles Elicited Higher and Broader Immune Responses than the Commercial Panenza Vaccine., J Pharm Pharmaco. 2014, 2(2014): 50-58. |
| Researcher : Chan E |
| List of Research Outputs |
| Chau C.S.K., Lee S.L., Peiris J.S.M., Chan K.H., Chan E., Wong W.H.S. and Chiu S.S.S., Adenovirus respiratory infection in hospitalized children in Hong Kong: serotype-clinical syndrome association and risk factors for lower respiratory tract infection., Eur J Pediatr. 2013. |
| Researcher : Chan J |
| List of Research Outputs |
| Chan J., Lo W.U., Chow K.H., Lai E.L.Y., Law P.Y.T. and Ho P.L., Clonal Diversity Of Escherichia Coli Carrying Plasmid-mediated Fosfomycin Resistance Fosa3 From Livestock And Other Animals, Antimicrob Agents Chemother.. US, ASM, 2014. |
| Ho P.L., Chan J., Lo W.U., Lai E.L.Y., CHEUNG Y.Y., Terrence L.A.U. and Chow K.H., Prevalence and molecular epidemiology of plasmid-mediated fosfomycin resistance genes among blood and urinary Escherichia coli isolates, J Med Microbiol. UK, 2013, 62: 1707-1713. |
| Ho P.L., Lo W.U., Chan J., CHEUNG Y.Y., Chow K.H., Yam W.C., Lin C. and Que T.L., pIMP-PH114 carrying bla IMP-4 in a Klebsiella pneumoniae strain is closely related to other multidrug-resistant IncA/C2 plasmids., Current Microbiology. Springer US, 2014, 68(2): 227-232. |
| Researcher : Chan JFW |
| Project Title: | Epidemiology, seroprevalence, and clinical manifestations of immunodeficiency due to autoantibody against interferon gamma in Hong Kong |
| Investigator(s): | Chan JFW, Hung IFN |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Mini Grant |
| Start Date: | 01/2014 |
| Project Title: | Incidence and clinical significance of Atopobium vaginae bacteremia in Hong Kong. |
| Investigator(s): | Chan JFW, Teng LL |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2014 |
| List of Research Outputs |
| Chan J.F.W., Associate Editor, BMC Infectious Diseases. 2014. |
| Chan J.F.W., Chan K.H., Kao R.Y.T., To K.K.W., Zheng B., Li P.Y., Li T.W., Dai J., Mok K.Y., Chen H., Hayden F.G. and Yuen K.Y., Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus., Journal of Infection. 2013, 67(6): 606-16. |
| Chan J.F.W., Decreased general condition – a common problem with many facets, The Global Emergency Medicine Meeting 2014, HKU-Shenzhen Hospital, Shenzhen, China. 2014. |
| Chan J.F.W., Emerging infectious diseases in southern China - the HKU perspective, 18th HMU Academic Lecture Hall Series, Hainan Medical University, Hainan, China. 2013. |
| Chan J.F.W., Teng L.L., Li W.S., Wong S.C.Y., Leung S.S.M., Ho P.O., To K.K.W., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Fatal empyema thoracis caused by Schizophyllum commune with cross-reactive cryptococcal antigenemia, Journal of Clinical Microbiology . 2014, 52: 683-687. |
| Chan J.F.W., Laboratory diagnostics for invasive fungal infection: how useful are they?, Invasive Fungal Infection Forum 2013, Department of Medicine, Li Ka Shing Faculty of Medicine, HKU. 2013. |
| Chan J.F.W., Chan K.H. and Yuen K.Y., Reply to Leow., The Journal of infectious diseases. 2013, 208(8): 1351-1352. |
| Chan J.F.W., Lau S.K.P., Wong S.C.Y., To K.K.W., Cheng V.C.C., Yuen K.Y. and Woo P.C.Y., Ten-year retrospective case series of patients with galactomannan antigenemia: implications on the use of serum galactomannan antigen in the diagnosis of invasive and non-invasive aspergillosis, ECCMID 2014, European Society of Clinical Microbiology and Infectious Diseases. 2014. |
| Chan J.F.W., Lau S.K.P. and Woo P.C.Y., The emerging novel Middle East Respiratory Syndrome Coronavirus: the “knowns” and “unknowns”. , Journal of Formosan Medical Association. 2013, 112: 372-381. |
| Chan J.F.W., The “not so common” causes of CNS infection in Hong Kong: diagnoses you cannot afford to miss, 3rd Hong Kong Neurological Congress cum 26th Annual Scientific Meeting, The Hong Kong Neurological Society. 2013. |
| Chan K.H., To K.K.W., Chan J.F.W., Li P.Y., Chen H. and Yuen K.Y., Analytical Sensitivity of Seven Point-of-Care Influenza Virus Detection Tests and Two Molecular Tests for Detection of Avian Origin H7N9 and Swine Origin H3N2 Variant Influenza A Viruses, Journal of Clinical Microbiology. 2013, 51(9): 3160-3161. |
| Chan K.H., To K.K.W., Chan J.F.W., Li P.Y., Chan K.M., Chen H., Ho P.L. and Yuen K.Y., Assessment of Antigen and Molecular Tests with Serial Specimens from a Patient with Influenza A(H7N9) Infection, Journal of Clinical Microbiology. 2014, 52(6): 2272-2274. |
| Cheng V.C.C., Chan J.F.W., To K.K.W. and Yuen K.Y., Clinical management and infection control of SARS: lessons learned., Antiviral research. 2013, 100(2): 407-419. |
| Cheng V.C.C., Wong S.C.Y., Sridhar S., Chan J.F.W., Ng M.L.M., Lau S.K.P., Woo P.C.Y., Lo E.C.M., Chan K.K.C. and Yuen K.Y., Management of an incident of failed sterilization of surgical instruments in a dental clinic in Hong Kong, Journal of the Formosan Medical Association. 2013, 112: 666-675. |
| Cheng V.C.C., Tai J.W.M., Chau P.H., Chen J.H.K., Yan M.K., So S.Y.C., To K.K.W., Chan J.F.W., Wong S.C.Y., Ho P.L. and Yuen K.Y., Minimal intervention for controlling nosocomial transmission of Methicillin-Resistant Staphylococcus aureus in resource limited setting with high endemicity, PLoS One. 2014, 9: e100493. |
| Chu H., Zhou J., Wong H.Y.B., Li C., Cheng Z., Lin X., Poon K.M., Sun T., Lau C.Y., Chan J.F.W., To K.K.W., Chan K.H., Lu L., Zheng B. and Yuen K.Y., Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response. , Virology. 2014, 454-455: 197-205. |
| Ho P.L., CHEUNG Y.Y., Lo W.U., LI Z., Chow K.H., Lin C., Chan J.F.W. and Cheng V.C.C., Molecular Characterization of an Atypical IncX3 Plasmid pKPC-NY79 Carrying bla KPC-2 in a Klebsiella pneumoniae. , Current Microbiology. 2013. |
| Hung I.F.N., Li T.W., To K.K.W., Ho T.Y., Chan J.F.W., Chan K.H. and Yuen K.Y., Efficacy of Combined Influenza and 23-valent Polysaccharide Pneumococcal Vaccines in Chronic Smoker, Pathogenesis of Respiratory Viruses at Keystone Resort, Colorado, USA, 19-24 January 2014. |
| Lau S.K.P., Lau C.Y., Chan K.H., Li P.Y., Chen H., Jin D., Chan J.F.W., Woo P.C.Y. and Yuen K.Y., Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment, Journal of General Virology. 2013, 94: 2679-2690. |
| Lau S.K.P., Tang B.S.F., Teng L.L., Chan T.M., Curreem S.O.T., Fan Y.Y., Ng R.H.Y., Chan J.F.W., Yuen K.Y. and Woo P.C.Y., Matrix-assisted laser desorption ionisation time-of-flight mass spectrometry for identification of clinically significant bacteria that are difficult to identify in clinical laboratories, Journal of Clinical Pathology . 2014, 67: 361-366. |
| Lee P.P.W., Mao H., Yang W., Chan K.W., Ho M.H.K., Lee T.L., Chan J.F.W., Woo P.C.Y., Tu W. and Lau Y.L., Penicillium marneffei infection and impaired IFN-γ immunity in humans with autosomal-dominant gain-of-phosphorylation STAT1 mutations, Journal of Allergy and Clinical Immunology. 2013. |
| Lu L., Liu Q., Zhu Y., Chan K.H., Qin L., Li Y., Wang Q., Chan J.F.W., Du L., Yu F., Ma C., Ye S., Yuen K.Y., Zhang R. and Jiang S., Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor., Nature communications. 2014. |
| Sridhar S., Chan J.F.W. and Yuen K.Y., First report of brain abscess caused by a satelliting phenotypic variant of Helcococcus kunzii., Journal of clinical microbiology. 2013, 52(1): 370-373. |
| To K.K.W., TSANG K.L., Chan J.F.W., Cheng V.C.C., Chen H. and Yuen K.Y., Emergence in China of human disease due to avian influenza A(H10N8) - Cause for concern?, Journal of Infection. 2014, 68(3): 205-215. |
| To K.K.W., Chan J.F.W., Chen H., Li L.J. and Yuen K.Y., The emergence of influenza A H7N9 in human beings 16 years after influenza A H5N1: a tale of two cities, Lancet Infectious Diseases. 2013, 13(9): 809-821. |
| To K.K.W., Chan J.F.W. and Yuen K.Y., Viral lung infections: epidemiology, virology, clinical features, and management of avian influenza A(H7N9)., Current opinion in pulmonary medicine. 2014, 20(3): 225-232. |
| Yang S.G., Chen Y., Cui D.W., Yao H.P., Lou J.Z., Huo Z.X., Xie G.L., Yu F., Zheng S.F., Yang Y.D., Zhu Y.X., Lu X.Q., Liu X.L., Lau S.Y., Chan J.F.W., To K.K.W., Yuen K.Y., Chen H. and Li L.J., Avian-Origin Influenza A(H7N9) Infection in Influenza A(H7N9)-Affected Areas of China: A Serological Study, Journal of Infectious Diseases. 2014, 209(2): 265-269. |
| Yu L., Wang Z.M., Chen Y., Ding W., Jia H.Y., Chan J.F.W., To K.K.W., Chen H., Yang Y.D., Liang W.F., Zheng S.F., Yao H.P., Yang S.G., Cao H.C., Dai X.H., Zhao H., Li J., Bao Q.L., Chen P., Hou X.L., Li L.J. and Yuen K.Y., Clinical, Virological, and Histopathological Manifestations of Fatal Human Infections by Avian Influenza A(H7N9) Virus, Clinical Infectious Diseases. 2013, 57(10): 1449-1457. |
| Zhang J., Li C., To K.K.W., Zhu H., Lee C.Y., Li C., Chan J.F.W., Hung I.F.N. and Yuen K.Y., Toll-like receptor 7 agonist imiquimod in combination with influenza vaccine expedites and augments humoral immune responses against influenza A(H1N1)pdm09 virus infection in BALB/c mice., Clinical and vaccine immunology. 2014, 21(4): 570-579. |
| Zhou J., Chu H., Li C., Wong H.Y.B., Cheng Z., Poon K.M., Sun T., Lau C.Y., Wong K.K., Chan J.Y.K., Chan J.F.W., To K.K.W., Chan K.H., Zheng B. and Yuen K.Y., Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis., J Infect Dis. 2014, 209(9): 1331-42. |
| Researcher : Chan KCW |
| List of Research Outputs |
| To W.C.S., Chen J.H.K., Wong K.H., Chan K.C.W., Ng H.M., Wu H., Lam T.H. and Yam W.C., Performance comparison of an in-house integrase genotyping assay versus the ViroSeq (TM) Integra48, and study of HIV-1 integrase polymorphisms in Hong Kong, In: To SW, Chen JH, Wong KH, Chan KC, Ng HM, Wu H, Lam JT, Yam WC, J Clin Virol. 2013, 58(1): 299-302. |
| Researcher : Chan KH |
| List of Research Outputs |
| Chan J.F.W., Chan K.H., Kao R.Y.T., To K.K.W., Zheng B., Li P.Y., Li T.W., Dai J., Mok K.Y., Chen H., Hayden F.G. and Yuen K.Y., Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus., Journal of Infection. 2013, 67(6): 606-16. |
| Chan J.F.W., Chan K.H. and Yuen K.Y., Reply to Leow., The Journal of infectious diseases. 2013, 208(8): 1351-1352. |
| Chan K.H., To K.K.W., Chan J.F.W., Li P.Y., Chen H. and Yuen K.Y., Analytical Sensitivity of Seven Point-of-Care Influenza Virus Detection Tests and Two Molecular Tests for Detection of Avian Origin H7N9 and Swine Origin H3N2 Variant Influenza A Viruses, Journal of Clinical Microbiology. 2013, 51(9): 3160-3161. |
| Chan K.H., To K.K.W., Chan J.F.W., Li P.Y., Chan K.M., Chen H., Ho P.L. and Yuen K.Y., Assessment of Antigen and Molecular Tests with Serial Specimens from a Patient with Influenza A(H7N9) Infection, Journal of Clinical Microbiology. 2014, 52(6): 2272-2274. |
| Chan K.P., Wong C.M., Chiu S.S.S., Chan K.H., WANG X., Chan L.Y., Peiris J.S.M. and Yang L., A Robust Parameter Estimation Method for Estimating Disease Burden of Respiratory Viruses, PLOS One. 2014, 9(3): e90126. |
| Chan T.C.I., Hung I.F.N., Chan K.H., Li P.Y., Li T.W., Luk J.K.H., Chu L.W. and Chan F.H.W., Immunogenicity and Safety of Intradermal Trivalent Influenza Vaccination in Nursing Home Older Adults: A Randomized Controlled Trial., Journal of American Medical Directors Association. 2014. |
| Chau C.S.K., Lee S.L., Peiris J.S.M., Chan K.H., Chan E., Wong W.H.S. and Chiu S.S.S., Adenovirus respiratory infection in hospitalized children in Hong Kong: serotype-clinical syndrome association and risk factors for lower respiratory tract infection., Eur J Pediatr. 2013. |
| Chiu S.S.S., Lo J.Y.C., Chan K.H., Chan L.Y., So L.Y., Wu P., Cowling B.J., Chen H.S.R. and Peiris J.S.M., Population-Based Hospitalization Burden of Influenza A Virus Subtypes and Antigenic Drift Variants in Children in Hong Kong (2004-2011), PLOS One. 2014, 9(4): e92914. |
| Chu H., Zhou J., Wong H.Y.B., Li C., Cheng Z., Lin X., Poon K.M., Sun T., Lau C.Y., Chan J.F.W., To K.K.W., Chan K.H., Lu L., Zheng B. and Yuen K.Y., Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response. , Virology. 2014, 454-455: 197-205. |
| Hung I.F.N., Li T.W., To K.K.W., Ho T.Y., Chan J.F.W., Chan K.H. and Yuen K.Y., Efficacy of Combined Influenza and 23-valent Polysaccharide Pneumococcal Vaccines in Chronic Smoker, Pathogenesis of Respiratory Viruses at Keystone Resort, Colorado, USA, 19-24 January 2014. |
| LEUNG H.L., McDevitt J., Chan K.H., Yen H., Ip D.K.M., Li Y., Leung G.M., Peiris J.S.M., Seto W.H., Milton D.K. and Cowling B.J., Efficacy of surgical face masks as source control in reducing influenza virus dissemination in human exhaled breath (abstract & poster presentation), Hong Kong College of Community Medicine Annual Scientific Meeting, 28 September 2013, Hong Kong. Hong Kong, HKCCM, 2013. |
| Lau S.K.P., Lau C.Y., Chan K.H., Li P.Y., Chen H., Jin D., Chan J.F.W., Woo P.C.Y. and Yuen K.Y., Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment, Journal of General Virology. 2013, 94: 2679-2690. |
| Lau S.K.P., Li K.S.M., Tsang K.L., Lam S.F., Ahmed S.S., Chen H., Chan K.H., Woo P.C.Y. and Yuen K.Y., Genetic Characterization of Betacoronavirus Lineage C Viruses in Bats Reveals Marked Sequence Divergence in the Spike Protein of Pipistrellus Bat Coronavirus HKU5 in Japanese Pipistrelle: Implications for the Origin of the Novel Middle East Respiratory Syndrome Coronavirus, Journal of Virology. 2013, 87: 8638-8650. |
| Lau S.K.P., Woo P.C.Y., WU Y., WONG Y.P., Wong B.H.L., Lau C.Y., Fan Y.Y., Cai J., Tsoi H.W., Chan K.H. and Yuen K.Y., Identification and characterization of a novel paramyxovirus, porcine parainfluenza 1 virus, from deceased pigs, Journal of General Virology. 2013, 94: 2184-2190. |
| Liu K.S.H., Hung I.F.N., Seto W.K.W., But Y.K.D., Hsu A.S.J., Tong S.M., Chan K.H., Tan V.P.Y. and Leung W.K., Immune Responses to intramuscular or intradermal trivalent influenza vaccines in patients with inflammatory bowel disease: A randomized controlled trial, Asian Organization for Crohn's and Colitis. 2014. |
| Lu L., Liu Q., Zhu Y., Chan K.H., Qin L., Li Y., Wang Q., Chan J.F.W., Du L., Yu F., Ma C., Ye S., Yuen K.Y., Zhang R. and Jiang S., Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor., Nature communications. 2014. |
| NING J., Chan K.H. and Chiang A.K.S., Development of immunodominance hierarchies concurrent with enhanced polyfunctionality in T cell immunity towards Epstein - Barr virus, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association Ltd Joint Annual Scientific Meeting 2013. 60. |
| Ng S., Ni M.Y., Fang J., Ip D.K.M., Chan K.H., Leung G.M., Peiris J.S.M. and Cowling B.J., Characteristics of vaccine failures in a randomized placebo-controlled trial of inactivated influenza vaccine in children , The Pediatric Infectious Disease Journal. 2014, 33(2): e63-6. |
| Ng S., Fang J., Ip D.K.M., Chan K.H., Leung G.M., Peiris J.S.M. and Cowling B.J., Estimation of the association between antibody titers and protection against confirmed influenza virus infection in children, Journal of Infectious Diseases. 2013, 208(8): 1320-4. |
| To K.K.W., Zhou J., Song Y., Hung I.F.N., Ip W.C.T., Cheng Z., Chan S.F., Kao R.Y.T., Wu A.K.L., Chau S.S., Luk W.K., Ip M.S.M., Chan K.H. and Yuen K.Y., Surfactant protein B gene polymorphism is associated with severe influenza., Chest. 2014, 145(6): 1237-1243. |
| WANG X., Wong C.M., Chan K.H., Chan K.P., CAO P., Peiris J.S.M. and Yang L., Hospitalization risk of the 2009 H1N1 pandemic cases in Hong Kong, BMC Infectious Diseases. 2014, 14: 32. |
| Wong C.M., Yang L., Chan K.P., Chan W.M., Song L., Lai H.K., Thach T.Q., Ho L.M., Chan K.H., Lam T.H. and Peiris J.S.M., Cigarette smoking as a risk factor for influenza-associated mortality: Evidence from an elderly cohort, Influenza and Other Respiratory Viruses. 2013, 7(4): 531-9. |
| Woo P.C.Y., Lau S.K.P., Wernery U., Wong Y.M., Tsang K.L., Johnson B., Yip C.Y., Lau C.Y., Sivakumar S., Cai J., Fan Y.Y., Chan K.H., Mareena R. and Yuen K.Y., Novel betacoronavirus in dromedaries of the Middle East, 2013, Emerging Infectious Diseases. 2014, 20: 560-572. |
| Yip C.Y., Lau S.K.P., Lo J.Y.C., Chan K.H., Woo P.C.Y. and Yuen K.Y., Genetic characterization of EV71 isolates from 2004 to 2010 reveals predominance and persistent circulation of the newly proposed genotype D and recent emergence of a distinct lineage of subgenotype C2 in Hong Kong, Virology Journal. 2013, 10: 222. |
| Yip C.Y., Lau S.K.P., Woo P.C.Y., Wong S.S.Y., Tsang T.H.F., Lo J.Y.C., Lam W.K., Tsang C.C., Chan K.H. and Yuen K.Y., Recombinant Coxsackievirus A2 and Deaths of Children, Hong Kong, 2012, Emerging Infectious Diseases. 2013, 19: 1285-1288. |
| Zhou J., Chu H., Li C., Wong H.Y.B., Cheng Z., Poon K.M., Sun T., Lau C.Y., Wong K.K., Chan J.Y.K., Chan J.F.W., To K.K.W., Chan K.H., Zheng B. and Yuen K.Y., Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis., J Infect Dis. 2014, 209(9): 1331-42. |
| Zhu X., Guo Y.H., Jiang T., Wang Y.D., Chan K.H., Li X.F., Yu W., McBride R., Paulson J.C., Yuen K.Y., Qin C.F., Che X.Y. and Wilson I.A., A unique and conserved neutralization epitope in H5N1 influenza viruses identified by an antibody against the A/Goose/Guangdong/1/96 hemagglutinin., Journal of virology. 2013, 87(23): 12619-12635. |
| Researcher : Chan KM |
| List of Research Outputs |
| Chan K.H., To K.K.W., Chan J.F.W., Li P.Y., Chan K.M., Chen H., Ho P.L. and Yuen K.Y., Assessment of Antigen and Molecular Tests with Serial Specimens from a Patient with Influenza A(H7N9) Infection, Journal of Clinical Microbiology. 2014, 52(6): 2272-2274. |
| Researcher : Chan MCW |
| Project Title: | Effect of vitamin B2 in the treatment of human influenza H5N1 virus infection: studies in vitro and in vivo |
| Investigator(s): | Chan MCW, Peiris JSM, Chan WY |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 02/2009 |
| Completion Date: | 08/2014 |
| Project Title: | Effect of allogeneic human mesenchymal stem cells on alveolar fluid clearance and protein permeability in human alveolar epithelial cells injured by influenza H5N1 virus infection |
| Investigator(s): | Chan MCW, Nicholls JM |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2010 |
| Project Title: | Experimental models to study the impact of cigarette smoking on the tropism of the highly pathogenic avian influenza H5N1 virus in human respiratory tract |
| Investigator(s): | Chan MCW, Chan WY, Nicholls JM, Mak JCW |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 02/2011 |
| Project Title: | Role of indirubin-3’-oxime as an antiviral and immunomodulatory agent in the treatment of severe human influenza virus infection |
| Investigator(s): | Chan MCW |
| Department: | School of Public Health |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 03/2012 |
| Project Title: | Therapeutic Effect of Human Umbilical Cord Mesenchymal Stem Cells on Acute Lung Injury Caused by Severe Influenza H5N1 Virus Infection |
| Investigator(s): | Chan MCW, Peiris JSM, Guan Y, Chan GCF, Chan WY |
| Department: | School of Public Health |
| Source(s) of Funding: | Matching Grant for Joint Research |
| Start Date: | 05/2012 |
| Project Title: | A comparative study of influenza A viruses with differential interferon induction with respect to their potential to confer increased susceptibility to secondary bacterial infections |
| Investigator(s): | Chan MCW |
| Department: | School of Public Health |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2012 |
| Completion Date: | 06/2014 |
| Project Title: | A mouse model to study the beneficial effect of human mesenchymal stem cells on acute lung injury induced by influenza H5N1 virus infection |
| Investigator(s): | Chan MCW |
| Department: | School of Public Health |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2013 |
| Project Title: | Role of distal airway stem cells in lung regeneration following highly pathogenic influenza H5N1 induced acute lung injury |
| Investigator(s): | Chan MCW, Wong MP, Nicholls JM |
| Department: | School of Public Health |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Tropism of the novel human betacoronavirus lineage C virus in human ex vivo and in vitro cultures, as an assessment of its potential transmissibility and pathogenesis in humans |
| Investigator(s): | Chan MCW, Chan WY, Nicholls JM, Peiris JSM |
| Department: | School of Public Health |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2014 |
| Project Title: | Host-directed antiviral strategy for influenza virus infection – optimization of statins use and the intimate linkage between sterol metabolism and interferon mediated antiviral response |
| Investigator(s): | Chan MCW |
| Department: | School of Public Health |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Researcher : Chan PY |
| List of Research Outputs |
| Ho P.L., Lai E.L.Y., Chan P.Y., Lo W.U. and Chow K.H., Rare occurrence of vancomycin-resistant Enterococcus faecium among livestock animals in China. , The Journal of antimicrobial chemotherapy. 2013. |
| Researcher : Chan SF |
| List of Research Outputs |
| To K.K.W., Lam C.W., Lee K.C., Yung K.Y., Law C.Y., Leung K.F., Lau K.C. and Chan S.F., Difference In The Metabolome Between Escherichia Coli Isolated From Patients With Pyelonephritis And Cholangitis, Metabolomics Society 2013 Conference . 2013. |
| To K.K.W., Zhou J., Song Y., Hung I.F.N., Ip W.C.T., Cheng Z., Chan S.F., Kao R.Y.T., Wu A.K.L., Chau S.S., Luk W.K., Ip M.S.M., Chan K.H. and Yuen K.Y., Surfactant protein B gene polymorphism is associated with severe influenza., Chest. 2014, 145(6): 1237-1243. |
| To K.K.W., Lam C.W., Wong S.S.Y., Law C.Y., Lee K.C., Yung K.Y., Cheung K.K. and Chan S.F., Urine Metabolomics Profile Of Patients With Or Without Bacteremia, International Symposium on Translating Omics Science to Clinical Applications 2013 (TOSCA'13). 2013. |
| Researcher : Chen H |
| Project Title: | Modification of cells for isolation and characterization of SARS CoV from animal sources |
| Investigator(s): | Chen H |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Funding for New Staff |
| Start Date: | 07/2004 |
| Project Title: | Biological function/relevance for the 29 nucleotides insertion in the genome of animal SARS like CoV |
| Investigator(s): | Chen H, Guan Y |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Project Title: | Antiviral drug resistance in H5N1 virus |
| Investigator(s): | Chen H, Guan Y |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2007 |
| Project Title: | Molecular basis for the regulation of influenza virus by nuclear factor NF90 |
| Investigator(s): | Chen H |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2011 |
| Completion Date: | 12/2013 |
| Project Title: | Options for the Control of Influenza VIII; Mammalian adaptation markers in avian-origin H7N9 virus, a comprehensive investigation in isolates and clinical specimens from the H7N9 influenza affected area |
| Investigator(s): | Chen H |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2013 |
| Project Title: | The role of RAP55 and P-bodies in the regulation of influenza virus replication |
| Investigator(s): | Chen H |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| List of Research Outputs |
| Chan J.F.W., Chan K.H., Kao R.Y.T., To K.K.W., Zheng B., Li P.Y., Li T.W., Dai J., Mok K.Y., Chen H., Hayden F.G. and Yuen K.Y., Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus., Journal of Infection. 2013, 67(6): 606-16. |
| Chan K.H., To K.K.W., Chan J.F.W., Li P.Y., Chen H. and Yuen K.Y., Analytical Sensitivity of Seven Point-of-Care Influenza Virus Detection Tests and Two Molecular Tests for Detection of Avian Origin H7N9 and Swine Origin H3N2 Variant Influenza A Viruses, Journal of Clinical Microbiology. 2013, 51(9): 3160-3161. |
| Chan K.H., To K.K.W., Chan J.F.W., Li P.Y., Chan K.M., Chen H., Ho P.L. and Yuen K.Y., Assessment of Antigen and Molecular Tests with Serial Specimens from a Patient with Influenza A(H7N9) Infection, Journal of Clinical Microbiology. 2014, 52(6): 2272-2274. |
| Chen Y., Li X., Tian L., Zheng S., Yang S., Dong Y., Wang Y., Cui D., Liu X., Liang W., Chen H. and Li L., Dynamic behavior of lymphocyte subgroups correlates with clinical outcomes in human H7N9 infection, J Infect. 2014. |
| Chen Y.X., Luo W.X., Zhang J., Xia Z.S., Guan Y. and Chen H., Monoclonal antibodies binding to avian influenza virus subtype H5 haemagglutinin and uses thereof, Official Gazette of the United States Patent and Trademark Office Patents. 2013. |
| Lau S.K.P., Lau C.Y., Chan K.H., Li P.Y., Chen H., Jin D., Chan J.F.W., Woo P.C.Y. and Yuen K.Y., Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment, Journal of General Virology. 2013, 94: 2679-2690. |
| Lau S.K.P., Li K.S.M., Tsang K.L., Lam S.F., Ahmed S.S., Chen H., Chan K.H., Woo P.C.Y. and Yuen K.Y., Genetic Characterization of Betacoronavirus Lineage C Viruses in Bats Reveals Marked Sequence Divergence in the Spike Protein of Pipistrellus Bat Coronavirus HKU5 in Japanese Pipistrelle: Implications for the Origin of the Novel Middle East Respiratory Syndrome Coronavirus, Journal of Virology. 2013, 87: 8638-8650. |
| Lei T., Yuen K.S., Tsao G.S.W., Chen H., Kok K.H. and Jin D., Perturbation of biogenesis and targeting of Epstein-Barr virus-encoded miR-BART3 microRNA by adenosine-to-inosine editing, Journal of General Virology. 2013, 94: 2739-2744. |
| Lei T., YUEN K.S., Xu R., Tsao G.S.W., Chen H., Li M., Kok K.H. and Jin D., Targeting of DICE1 tumor suppressor by Epstein-Barr virus-encoded miR-BART3* microRNA in nasopharyngeal carcinoma, International Journal of Cancer. 2013, 133: 79-87. |
| Song W., Wang P., Chen Y., Yang S., Wu N., Lau S.Y., Wu W.L., Mok B.W.Y., Cui D., Huo Z., Zheng M., Huang X., Li L., Yuen K.Y. and Chen H., Mammalian adaptation markers in avian-origin H7N9 virus, a comprehensive investigation in isolates and clinical specimens from the H7N9 influenza affected area, VIII Options for the control of influenza, Cape Town, South Africa, September 2013. |
| To K.K.W., TSANG K.L., Chan J.F.W., Cheng V.C.C., Chen H. and Yuen K.Y., Emergence in China of human disease due to avian influenza A(H10N8) - Cause for concern?, Journal of Infection. 2014, 68(3): 205-215. |
| To K.K.W., Chan J.F.W., Chen H., Li L.J. and Yuen K.Y., The emergence of influenza A H7N9 in human beings 16 years after influenza A H5N1: a tale of two cities, Lancet Infectious Diseases. 2013, 13(9): 809-821. |
| WEN X., HUANG X., Mok B.W.Y., Chen Y.X., ZHENG M., Lau S.Y., Wang P., Song W., Jin D., Yuen K.Y. and Chen H., NF90 Exerts Antiviral Activity through Regulation of PKR Phosphorylation and Stress Granules in Infected Cells, Journal of Immunology. 2014, 192(8): 3753-3764. |
| Wu H.Z., Song W., Gao X., Liu N., Wang P., Chen H. and Cai Z.W., Proteomics study of N-acetylcysteine response in H1N1-infected cells by using mass spectrometry, Rapid Communications in Mass Spectrometry. 2014, 28(7): 741-749. |
| Xu L.L., Bao L.L., Yuan J., Li F.D., Lv Q., Deng W., Xu Y.F., Yao Y.F., Yu P., Chen H., Yuen K.Y. and Qin C., Antigenicity and transmissibility of a novel clade 2.3.2.1 avian influenza H5N1 virus, Journal of General Virology. 2013, 94: 2616-2626. |
| Xu L.L., Bao L.L., Deng W., Dong L.B., Zhu H., Chen T., Lv Q., Li F.D., Yuan J., Xiang Z.G., Gao K., Xu Y.F., Huang L., Li Y.H., Liu J.N., Yao Y.F., Yu P., Li X.Y., Huang W.J., Zhao X., Lan Y., Guo J.F., Yong W.D., Wei Q., Chen H., Zhang L.F. and Qin C., Novel Avian-Origin Human Influenza A(H7N9) Can Be Transmitted Between Ferrets via Respiratory Droplets, Journal of Infectious Diseases. 2014, 209(4): 551-556. |
| Xu L.L., Bao L.L., Deng W., Zhu H., Li F.D., Chen T., Lv Q., Yuan J., Xu Y.F., Li Y.H., Yao Y.F., Gu S.Z., Yu P., Chen H. and Qin C., Rapid adaptation of avian H7N9 virus in pigs, Virology. 2014, 452: 231-236. |
| Yang S.G., Chen Y., Cui D.W., Yao H.P., Lou J.Z., Huo Z.X., Xie G.L., Yu F., Zheng S.F., Yang Y.D., Zhu Y.X., Lu X.Q., Liu X.L., Lau S.Y., Chan J.F.W., To K.K.W., Yuen K.Y., Chen H. and Li L.J., Avian-Origin Influenza A(H7N9) Infection in Influenza A(H7N9)-Affected Areas of China: A Serological Study, Journal of Infectious Diseases. 2014, 209(2): 265-269. |
| Yao Y.F., Bao L.L., Deng W., Xu L.L., Li F.D., Lv Q., Yu P., Chen T., Xu Y.F., Zhu H., Yuan J., Gu S.Z., Wei Q., Chen H., Yuen K.Y. and Qin C., An Animal Model of MERS Produced by Infection of Rhesus Macaques With MERS Coronavirus, Journal of Infectious Diseases. 2014, 209(2): 236-242. |
| Yu L., Wang Z.M., Chen Y., Ding W., Jia H.Y., Chan J.F.W., To K.K.W., Chen H., Yang Y.D., Liang W.F., Zheng S.F., Yao H.P., Yang S.G., Cao H.C., Dai X.H., Zhao H., Li J., Bao Q.L., Chen P., Hou X.L., Li L.J. and Yuen K.Y., Clinical, Virological, and Histopathological Manifestations of Fatal Human Infections by Avian Influenza A(H7N9) Virus, Clinical Infectious Diseases. 2013, 57(10): 1449-1457. |
| Researcher : Chen JHK |
| Project Title: | Molecular epidemiology study of HIV-1 among the men who have sex with men (MSM) population in Hong Kong |
| Investigator(s): | Chen JHK, Yam WC |
| Department: | Microbiology |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 04/2009 |
| List of Research Outputs |
| Chen J.H.K., Yam W.C., Ngan A.H.Y., Fung A.M.Y., Woo W.L., Yan M.K., Choi G.K.Y., Ho P.L., Cheng V.C.C. and Yuen K.Y., Advantages of Using Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry as a Rapid Diagnostic Tool for Identification of Yeasts and Mycobacteria in the Clinical Microbiological Laboratory, Journal of Clinical Microbiology. 2013, 51: 3981-3987. |
| Cheng V.C.C., Tai J.W.M., Chau P.H., Chen J.H.K., Yan M.K., So S.Y.C., To K.K.W., Chan J.F.W., Wong S.C.Y., Ho P.L. and Yuen K.Y., Minimal intervention for controlling nosocomial transmission of Methicillin-Resistant Staphylococcus aureus in resource limited setting with high endemicity, PLoS One. 2014, 9: e100493. |
| Cheng V.C.C., Tai J.W.M., Chen J.H.K., So S.Y., Ng W.C., Hung I.F.N., Leung S.S., Wong S.C.Y., Chan T.C., Chan F.H., Ho P.L. and Yuen K.Y., Proactive infection control measures to prevent nosocomial transmission of vancomycin-resistant enterococci in Hong Kong.ournal of the Formosan Medical Association, Journal of the Formosan Medical Association. 2014. |
| Ho P.L., Chau P.H., Yan M.K., Chow K.H., Chen J.H.K., Wong S.C.Y. and Cheng V.C.C., High burden of extended-spectrum β-lactamase-positive Escherichia coli in geriatric patients, Journal of Medical Microbiology. 2014, 63: 878-883. |
| Tam W.T., Chen J.H.K., Lau E.C.L., Ngan A.H.Y., Fung K.S.C., Lee K.C., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Misidentification of Aspergillus nomius and Aspergillus tamarii as Aspergillus flavus: Characterization by Internal Transcribed Spacer, -Tubulin, and Calmodulin Gene Sequencing, Metabolic Fingerprinting, and Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry, In: Tam EW, Chen JH, Lau EC, Ngan AH, Fung KS, Lee KC, Lam CW, Yuen KY, Lau SK, Woo PC, Journal of Clinical Microbiology. 2014, 52: 1153-1160. |
| Tam W.T., Chen J.H.K., Lau E.C., Ngan A.H., Fung K.S., Lee K.C., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Misidentification of Aspergillus nomius and Aspergillus tamarii as Aspergillus flavus: characterization by internal transcribed spacer, β-Tubulin, and calmodulin gene sequencing, metabolic fingerprinting, and matrix-assisted laser desorption ionization-time of flight mass spectrometry, In: Tam EW, Chen JH, Lau EC, Ngan AH, Fung KS, Lee KC, Lam CW, Yuen KY, Lau SK, Woo PC, J Clin Microbiol. 2014. |
| To W.C.S., Chen J.H.K., Wong K.H., Chan K.C.W., Ng H.M., Wu H., Lam T.H. and Yam W.C., Performance comparison of an in-house integrase genotyping assay versus the ViroSeq (TM) Integra48, and study of HIV-1 integrase polymorphisms in Hong Kong, In: To SW, Chen JH, Wong KH, Chan KC, Ng HM, Wu H, Lam JT, Yam WC, J Clin Virol. 2013, 58(1): 299-302. |
| Researcher : Chen M |
| Project Title: | Immunogenicity and Cross-Protective Effect of Novel human T cell Epitopes in H5N1 influenza virus nucleoprotein |
| Investigator(s): | Chen M, Zheng B |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2010 |
| List of Research Outputs |
| ZHANG N., LIN Y., Chen M., LEUNG H.C., Chan C.S., Poon K.M., Zhou J., Cheung C.Y., Lu L. and Zheng B., Pandemic A/H1N1 2009 Influenza Virus-like Particles Elicited Higher and Broader Immune Responses than the Commercial Panenza Vaccine., J Pharm Pharmaco. 2014, 2(2014): 50-58. |
| Researcher : Chen Z |
| Project Title: | A novel model for the study of lung pathogenesis of SARS |
| Investigator(s): | Chen Z |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | National Institutes of Health, US Department of Health and Human Services - General Award |
| Start Date: | 08/2007 |
| Project Title: | Understanding the Ongoing HIV Epidemic in Yunnan China |
| Investigator(s): | Chen Z |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | China AIDS Initiative - General Award |
| Start Date: | 05/2008 |
| Project Title: | Preventing HIV-1 infection using a novel vaccine immunogen |
| Investigator(s): | Chen Z |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Global Health Grants |
| Start Date: | 10/2008 |
| Project Title: | Establishment of a rapid, high-throughput, cost-effective HIV-1 drug resistance testing system |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 05/2011 |
| Project Title: | A Novel Vaccine for Mesothelioma Immunotherapy and Prevention; |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | Pneumoconiosis Compensation Fund Board - General Award |
| Start Date: | 07/2011 |
| Project Title: | A promising mucosal prime and intramuscular boost AIDS vaccine regimen |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2011 |
| Project Title: | AIDS Vaccine 2011 A Novel Vaccine Design for Inducing Robust HIV-1 Specific Immunity |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2011 |
| Project Title: | A Novel Vaccine for Tuberculosis Prevention |
| Investigator(s): | Chen Z, Yam WC |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 11/2011 |
| Project Title: | Blocking HIV infection by gene-encoding neutralizing antibodies |
| Investigator(s): | Chen Z, Liu L |
| Department: | Microbiology |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2012 |
| Project Title: | AIDS Vaccine 2012; Mucosal Prime with a Replicating Vaccinia-based Vaccine Promotes Mucosal Immunity against SIV. |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2012 |
| Project Title: | Mechanism of a soluble PD-1-based vaccine in amplifying antiviral CD8+ T-cell immunity |
| Investigator(s): | Chen Z, Liu L |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Project Title: | Novel Secretory Immunoadhesins for HIV Prevention |
| Investigator(s): | Chen Z, Cheung KLA |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2013 |
| Project Title: | To Establish a Novel and Rapid Phenotypic HIV-1 Drug Resistance Testing System |
| Investigator(s): | Chen Z, Liu L, Cheung KW, Du DY |
| Department: | Microbiology |
| Source(s) of Funding: | Guangdong-Hong Kong Technology Cooperation Funding Scheme |
| Start Date: | 07/2013 |
| Project Title: | AIDS Vaccine 2013 Conference; Mechanism of a Novel PD1-Based DNA Vaccine in Amplifying HIV-1 GAG-Specific CD8+ T Cells in Mice |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2013 |
| Completion Date: | 10/2013 |
| Project Title: | Further optimization of live viral vector for HIV vaccine research |
| Investigator(s): | Chen Z, Wang H |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 11/2013 |
| Project Title: | To Establish a Novel and Rapid Phenotypic HIV-1 Drug Resistance Testing System |
| Investigator(s): | Chen Z, Liu L, Cheung KW, Du DY |
| Department: | Microbiology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 12/2013 |
| Project Title: | Mechanism of potentiating HIV antigen-specific CD8+ T cells |
| Investigator(s): | Chen Z, Liu L, Yam WC, Cheung KLA, Cheung KW |
| Department: | Microbiology |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 06/2014 |
| List of Research Outputs |
| Peng Q., Wang H., Wang H., Li X., LU X., Liu L., Zhou B. and Chen Z., Imbalances of Gut-Homing CD4+ T-Cell Subsets in HIV-1–Infected Chinese Patients, JAIDS Journal of Acquired Immune Deficiency Syndromes. 2013, 64: 25-31. |
| Peng Q., Chen Z., Wang H., Li X., LU X., Liu L., Zhou B. and Wang H., Imbalances of gut-homing CD4+ T cell subsets in HIV-1 infected Chinese patients., Journal of Acquired Immune Deficiency Syndromes. 2013, 64(1): 25-31. |
| To S., Chen J.H.K., Wong K., Chan K., Chen Z. and Yam W.C., Determination of the High Prevalence of Dual/Mixed- or X4-Tropism Among HIV Type 1 CRF01_AE in Hong Kong by Genotyping and Phenotyping Methods, AIDS Research and Human Retroviruses. 2013, 29: 1123-1128. |
| ZHANG Y., YUAN T., Li J., Zhang Y., Xu J., Shao Y., Chen Z. and Zhang M., The potential of the human immune system to develop broadly neutralizing HIV-1 antibodies: implications for vaccine development, In: JA Levy, AIDS. 2013, 27: 2529-2539. |
| ZHOU J., Cheung K.L.A., Liu H., TAN Z., TANG X., KANG Y., Du Y., Wang H., Liu L. and Chen Z., Potentiating Functional Antigen-specific CD8+ T Cell Immunity by a Novel PD1 Isoform-based Fusion DNA Vaccine, Molecular Therapy. 2013, 21: 1445-1455. |
| Researcher : Cheng VCC |
| List of Research Outputs |
| CHUI S.L.C., Man K.C.K., Cheng C.L., Chan E.W., LAU C.Y., Cheng V.C.C., Wong D.S.H., Yan-Kao Y.E. and Wong I.C.K., An investigation of the association between retinal detachment and oral fluoroquinolones: a self-controlled case series study. , J Antimicrobial chemotherapy.. 2014. |
| Chan F.H., Chan T.C.I., Hung I.F.N., Luk J.K.H., Chu L.W., Ng W.C., Law T.C. and Cheng V.C.C., Early Identification of an Influenza Outbreak in a Nursing Home with High Vaccination Coverage Facilitates Implementation of Infection-Control Measures and Prevents Spreading of Influenza Infection, Journal of American Medical Directors Association. 2014, 15(4): 300-1. |
| Chan J.F.W., Lau S.K.P., Wong S.C.Y., To K.K.W., Cheng V.C.C., Yuen K.Y. and Woo P.C.Y., Ten-year retrospective case series of patients with galactomannan antigenemia: implications on the use of serum galactomannan antigen in the diagnosis of invasive and non-invasive aspergillosis, ECCMID 2014, European Society of Clinical Microbiology and Infectious Diseases. 2014. |
| Chan T.C.I., Hung I.F.N., Cheng V.C.C., Luk J.K.H., Chu L.W. and Chan F.H.W., Inadequate Knowledge of Pneumococcal Vaccine of Nursing Home Healthcare Workers Affects the Pneumococcal Vaccination Uptake of Older Adults in Nursing Homes , Journal of the American Geriatrics Society . 2013, 61(8): 1429-1430. |
| Chan T.C.I., Hung I.F.N., Cheng V.C.C., Luk J.K.H., Chu L.W. and Chan F.H.W., Is Nursing Home Residence an Independent Predictor of Recurrent Hospitalization in Older Adults?, Journal of the American Medical Directors Association . 2013, 14(9): 706-707. |
| Chan T.C.I., Hung I.F.N., Cheng V.C.C., Luk J.K.H., Woo P.C.Y., Chu L.W. and Chan F.H.W., Is Nursing Home Residence an Independent Risk Factor of Mortality in Chinese Older Adults?, Journal of the American Geriatrics Society . 2013, 61(8): 1430-1432. |
| Chen J.H.K., Yam W.C., Ngan A.H.Y., Fung A.M.Y., Woo W.L., Yan M.K., Choi G.K.Y., Ho P.L., Cheng V.C.C. and Yuen K.Y., Advantages of Using Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry as a Rapid Diagnostic Tool for Identification of Yeasts and Mycobacteria in the Clinical Microbiological Laboratory, Journal of Clinical Microbiology. 2013, 51: 3981-3987. |
| Cheng V.C.C., Chan J.F.W., To K.K.W. and Yuen K.Y., Clinical management and infection control of SARS: lessons learned., Antiviral research. 2013, 100(2): 407-419. |
| Cheng V.C.C., Wong S.C.Y., Sridhar S., Chan J.F.W., Ng M.L.M., Lau S.K.P., Woo P.C.Y., Lo E.C.M., Chan K.K.C. and Yuen K.Y., Management of an incident of failed sterilization of surgical instruments in a dental clinic in Hong Kong, Journal of the Formosan Medical Association. 2013, 112: 666-675. |
| Cheng V.C.C., Tai J.W.M., Chau P.H., Chen J.H.K., Yan M.K., So S.Y.C., To K.K.W., Chan J.F.W., Wong S.C.Y., Ho P.L. and Yuen K.Y., Minimal intervention for controlling nosocomial transmission of Methicillin-Resistant Staphylococcus aureus in resource limited setting with high endemicity, PLoS One. 2014, 9: e100493. |
| Cheng V.C.C., Tai J.W.M., Chen J.H.K., So S.Y., Ng W.C., Hung I.F.N., Leung S.S., Wong S.C.Y., Chan T.C., Chan F.H., Ho P.L. and Yuen K.Y., Proactive infection control measures to prevent nosocomial transmission of vancomycin-resistant enterococci in Hong Kong.ournal of the Formosan Medical Association, Journal of the Formosan Medical Association. 2014. |
| Chui S.L.C., Man K.C.K., Cheng C.L., Chan E.W., Lau C.Y., Cheng V.C.C., Wong D.S.H., Yang-Kao Y.H. and Wong I.C.K., An investigation of the association between retinal detachment and oral fluoroquinolones: A self-controlled case series study, Hong Kong Pharmaceutical Journal: 8th Asian Conference on Pharmacoepidemiology, October 25 - 27, 2013, Hong Kong . 2013, 20(3): 151. |
| He Y., Chan E.W., Cheng V.C.C., Lau C.Y., Man K.C.K. and Wong I.C.K., High-versus-low-dose histamine-2 antagonists for the prophylaxis of non-steroidal anti-inflammatory drug-associated gastrointestinal ulcers, Hong Kong Pharmaceutical Journal: 8th Asian Conference on Pharmacoepidemiology, October 25 - 27, 2013, Hong Kong . 2013, 20(3): 170. |
| Ho P.L., Chau P.H., Yan M.K., Chow K.H., Chen J.H.K., Wong S.C.Y. and Cheng V.C.C., High burden of extended-spectrum β-lactamase-positive Escherichia coli in geriatric patients, Journal of Medical Microbiology. 2014, 63: 878-883. |
| Ho P.L., CHEUNG Y.Y., Lo W.U., LI Z., Chow K.H., Lin C., Chan J.F.W. and Cheng V.C.C., Molecular Characterization of an Atypical IncX3 Plasmid pKPC-NY79 Carrying bla KPC-2 in a Klebsiella pneumoniae. , Current Microbiology. 2013. |
| To K.K.W., TSANG K.L., Chan J.F.W., Cheng V.C.C., Chen H. and Yuen K.Y., Emergence in China of human disease due to avian influenza A(H10N8) - Cause for concern?, Journal of Infection. 2014, 68(3): 205-215. |
| Researcher : Cheng Z |
| List of Research Outputs |
| Chu H., Zhou J., Wong H.Y.B., Li C., Cheng Z., Lin X., Poon K.M., Sun T., Lau C.Y., Chan J.F.W., To K.K.W., Chan K.H., Lu L., Zheng B. and Yuen K.Y., Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response. , Virology. 2014, 454-455: 197-205. |
| To K.K.W., Zhou J., Song Y., Hung I.F.N., Ip W.C.T., Cheng Z., Chan S.F., Kao R.Y.T., Wu A.K.L., Chau S.S., Luk W.K., Ip M.S.M., Chan K.H. and Yuen K.Y., Surfactant protein B gene polymorphism is associated with severe influenza., Chest. 2014, 145(6): 1237-1243. |
| Zhou J., Chu H., Li C., Wong H.Y.B., Cheng Z., Poon K.M., Sun T., Lau C.Y., Wong K.K., Chan J.Y.K., Chan J.F.W., To K.K.W., Chan K.H., Zheng B. and Yuen K.Y., Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis., J Infect Dis. 2014, 209(9): 1331-42. |
| Researcher : Cheung CY |
| Project Title: | A comparative study on the role of type I and III interferons in primary human cellular response to influenza virus infection |
| Investigator(s): | Cheung CY |
| Department: | School of Public Health |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2013 |
| Project Title: | Biomarkers & Diagnostics World Congress; Diagnosis and assessment of severity in respiratory infectious diseases using host gene expression profiles |
| Investigator(s): | Cheung CY |
| Department: | School of Public Health |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2013 |
| List of Research Outputs |
| ZHANG N., LIN Y., Chen M., LEUNG H.C., Chan C.S., Poon K.M., Zhou J., Cheung C.Y., Lu L. and Zheng B., Pandemic A/H1N1 2009 Influenza Virus-like Particles Elicited Higher and Broader Immune Responses than the Commercial Panenza Vaccine., J Pharm Pharmaco. 2014, 2(2014): 50-58. |
| Researcher : Cheung KK |
| List of Research Outputs |
| Tse M.K., Cheung K.K., Ke Y., Lau C.Y., Sze K.H. and Yuen K.Y., Backbone and side-chain ¹H, ¹³C and ¹⁵N assignments of the PPIase domain of macrophage infectivity potentiator (Mip) protein from Coxiella burnetii., Biomolecular NMR assignments. 2014, 8(1): 173-176. |
| Researcher : Cheung KLA |
| Project Title: | Transmission of HIV from infected myeloid progenitor cells to T cells |
| Investigator(s): | Cheung KLA, Chen Z |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2012 |
| Completion Date: | 11/2013 |
| Project Title: | Human cytomegalovirus and human immunodeficiency virus type 1 co-infection of CD34+ Myeloid Progenitor Cells |
| Investigator(s): | Cheung KLA, Chen Z |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2013 |
| Project Title: | Transfer of HIV-1 from HIV-1 latently infected CD34+ hematopoietic progenitors to CD4+ T cells |
| Investigator(s): | Cheung KLA, Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 02/2014 |
| Researcher : Cho LCK |
| List of Research Outputs |
| WONG K.H., Sze K.H., CHEN T., Cho L.C.K., LAW C.H., Chu I.K. and Wong A.O.L., Goldfish spexin: solution structure and novel function as a satiety factor in feeding control., Am. J. Physiol. Endocrinol. Metab.. 2013, 305(3): E348-E366. |
| Researcher : Choi KY |
| List of Research Outputs |
| Liu R., To K.K.W., Teng L.L., Choi K.Y., Mok K.Y., Law K.I., Tso E.Y., Fung K.S., Wu T.C., Wu A.K.L., Fung S.H., Wong S.C.Y., Trendell-Smith N.J. and Yuen K.Y., Mycobacterium abscessus bacteremia after receipt of intravenous infusate of cytokine-induced killer cell therapy for body beautification and health boosting., Clinical infectious diseases. 2013, 57(7): 981-991. |
| Researcher : Chong TK |
| List of Research Outputs |
| Yang E., Wang G., Woo P.C.Y., Lau S.K.P., Chow W.N., Chong T.K., Tse H., Kao R.Y.T., Chan C.M., Che X., Yuen K.Y. and Cai J.J., Unraveling the molecular basis of temperature-dependent genetic regulation in Penicillium marneffei, Eukaryotic Cell . 2013, 12: 1214-1224. |
| Researcher : Chow KH |
| List of Research Outputs |
| Chan J., Lo W.U., Chow K.H., Lai E.L.Y., Law P.Y.T. and Ho P.L., Clonal Diversity Of Escherichia Coli Carrying Plasmid-mediated Fosfomycin Resistance Fosa3 From Livestock And Other Animals, Antimicrob Agents Chemother.. US, ASM, 2014. |
| Che C.M., Sun R.W.Y., Wang Y. and Chow K.H., Treating cancer (e.g. cervical epithelioid carcinoma, hepatocellular carcinoma, breast carcinoma and/or lung carcinoma) comprises administering composition comprising new or known substituted gold(III) porphyrin complexes, European Patent Office. 2014, EP2493897-B1. |
| Ho P.L., Chau P.H., Yan M.K., Chow K.H., Chen J.H.K., Wong S.C.Y. and Cheng V.C.C., High burden of extended-spectrum β-lactamase-positive Escherichia coli in geriatric patients, Journal of Medical Microbiology. 2014, 63: 878-883. |
| Ho P.L., CHEUNG Y.Y., Lo W.U., LI Z., Chow K.H., Lin C., Chan J.F.W. and Cheng V.C.C., Molecular Characterization of an Atypical IncX3 Plasmid pKPC-NY79 Carrying bla KPC-2 in a Klebsiella pneumoniae. , Current Microbiology. 2013. |
| Ho P.L., Chan J., Lo W.U., Lai E.L.Y., CHEUNG Y.Y., Terrence L.A.U. and Chow K.H., Prevalence and molecular epidemiology of plasmid-mediated fosfomycin resistance genes among blood and urinary Escherichia coli isolates, J Med Microbiol. UK, 2013, 62: 1707-1713. |
| Ho P.L., Lai E.L.Y., Chan P.Y., Lo W.U. and Chow K.H., Rare occurrence of vancomycin-resistant Enterococcus faecium among livestock animals in China. , The Journal of antimicrobial chemotherapy. 2013. |
| Ho P.L., Lo W.U., Chan J., CHEUNG Y.Y., Chow K.H., Yam W.C., Lin C. and Que T.L., pIMP-PH114 carrying bla IMP-4 in a Klebsiella pneumoniae strain is closely related to other multidrug-resistant IncA/C2 plasmids., Current Microbiology. Springer US, 2014, 68(2): 227-232. |
| Lo W.U., Chow K.H., LAW Y.T., NG K.Y., CHEUNG Y.Y., Lai E.L.Y. and Ho P.L., Highly conjugative IncX4 plasmids carrying blaCTX-M in Escherichia coli from human and food animals. , Journal of medical microbiology. United Kingdom, 2014, 63: 835-40. |
| Researcher : Chow WN |
| List of Research Outputs |
| Lau S.K.P., Chow W.N., Wong Y.P., Yeung M.Y., Bao Y., Zhang N., Lok S., Woo P.C.Y. and Yuen K.Y., Identification of MicroRNA-like RNAs in Mycelial and yeast phases of the thermal dimorphic fungus Penicillium marneffei, PLoS Neglected Tropical Diseases. 2013, 7: e2398. |
| Yang E., Wang G., Woo P.C.Y., Lau S.K.P., Chow W.N., Chong T.K., Tse H., Kao R.Y.T., Chan C.M., Che X., Yuen K.Y. and Cai J.J., Unraveling the molecular basis of temperature-dependent genetic regulation in Penicillium marneffei, Eukaryotic Cell . 2013, 12: 1214-1224. |
| Researcher : Chu H |
| List of Research Outputs |
| Chu H., Zhou J., Wong H.Y.B., Li C., Cheng Z., Lin X., Poon K.M., Sun T., Lau C.Y., Chan J.F.W., To K.K.W., Chan K.H., Lu L., Zheng B. and Yuen K.Y., Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response. , Virology. 2014, 454-455: 197-205. |
| Zhou J., Chu H., Li C., Wong H.Y.B., Cheng Z., Poon K.M., Sun T., Lau C.Y., Wong K.K., Chan J.Y.K., Chan J.F.W., To K.K.W., Chan K.H., Zheng B. and Yuen K.Y., Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis., J Infect Dis. 2014, 209(9): 1331-42. |
| Researcher : Curreem SOT |
| List of Research Outputs |
| Lau S.K.P., Tang B.S.F., Teng L.L., Chan T.M., Curreem S.O.T., Fan Y.Y., Ng R.H.Y., Chan J.F.W., Yuen K.Y. and Woo P.C.Y., Matrix-assisted laser desorption ionisation time-of-flight mass spectrometry for identification of clinically significant bacteria that are difficult to identify in clinical laboratories, Journal of Clinical Pathology . 2014, 67: 361-366. |
| Lau S.K.P., Tse H., CHAN S.Y.J., Zhou A.C., Curreem S.O.T., Lau C.Y., Yuen K.Y. and Woo P.C.Y., Proteome profiling of the dimorphic fungus Penicillium marneffei extracellular proteins and identification of glyceraldehyde-3-phosphate dehydrogenase as an important adhesion factor for conidial attachment, FEBS Journal . 2013, 280: 6613-6626. |
| Lau S.K.P., Curreem S.O.T., Lin C.C.N., Fung A.M.Y., Yuen K.Y. and Woo P.C.Y., Streptococcus hongkongensis sp. nov., isolated from a patient with an infected puncture wound and from a marine flatfish., International Journal of Systematic and Evolutionary Microbiology. 2013, 63: 2570-2576. |
| Tse C.W.S., Curreem S.O.T., Cheung I., Tang B.S.F., Leung K.W., Lau S.K.P. and Woo P.C.Y., Novel MLST sequence type clustered with other sequence types of human isolates discovered in first fatal case of Laribacter hongkongensis bacteremia, Emerging Microbes and Infections . 2014, 3: e41. |
| Researcher : Dai J |
| List of Research Outputs |
| Chan J.F.W., Chan K.H., Kao R.Y.T., To K.K.W., Zheng B., Li P.Y., Li T.W., Dai J., Mok K.Y., Chen H., Hayden F.G. and Yuen K.Y., Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus., Journal of Infection. 2013, 67(6): 606-16. |
| Researcher : Fan YY |
| List of Research Outputs |
| Lau S.K.P., Woo P.C.Y., WU Y., WONG Y.P., Wong B.H.L., Lau C.Y., Fan Y.Y., Cai J., Tsoi H.W., Chan K.H. and Yuen K.Y., Identification and characterization of a novel paramyxovirus, porcine parainfluenza 1 virus, from deceased pigs, Journal of General Virology. 2013, 94: 2184-2190. |
| Lau S.K.P., Tang B.S.F., Teng L.L., Chan T.M., Curreem S.O.T., Fan Y.Y., Ng R.H.Y., Chan J.F.W., Yuen K.Y. and Woo P.C.Y., Matrix-assisted laser desorption ionisation time-of-flight mass spectrometry for identification of clinically significant bacteria that are difficult to identify in clinical laboratories, Journal of Clinical Pathology . 2014, 67: 361-366. |
| Tang B.S.F., Lau S.K.P., Teng L.L., Chan T.M., Chan W.S., Wong T.Y., Tong Y.T., Fan Y.Y., Yuen K.Y. and Woo P.C.Y., Matrix-assisted laser desorption ionisation-time of flight mass spectrometry for rapid identification of Laribacter hongkongensis, Journal of Clinical Pathology . 2013, 66: 1081-1083. |
| Woo P.C.Y., Lau S.K.P., Lam S.F., Tsang K.L., Hui S.W., Fan Y.Y., Martelli P. and Yuen K.Y., Discovery of a novel bottlenose dolphin coronavirus reveals a distinct species of marine mammal coronavirus in Gammacoronavirus, Journal of Virology . 2014, 88: 1318-1331. |
| Woo P.C.Y., Lau S.K.P., Wernery U., Wong Y.M., Tsang K.L., Johnson B., Yip C.Y., Lau C.Y., Sivakumar S., Cai J., Fan Y.Y., Chan K.H., Mareena R. and Yuen K.Y., Novel betacoronavirus in dromedaries of the Middle East, 2013, Emerging Infectious Diseases. 2014, 20: 560-572. |
| Researcher : Guan Y |
| Project Title: | Vaccines for the control of H5N1 and other avian influenza viruses |
| Investigator(s): | Guan Y |
| Department: | Microbiology |
| Source(s) of Funding: | The University of Hong Kong Foundation Seed Grant |
| Start Date: | 04/2002 |
| Project Title: | Searching for the precursor of SARS-Cov in Southern China |
| Investigator(s): | Guan Y |
| Department: | Microbiology |
| Source(s) of Funding: | VCO SARS Research Fund |
| Start Date: | 07/2003 |
| Project Title: | State Key Laboratory of Emerging Infectious Diseases |
| Investigator(s): | Guan Y |
| Department: | Microbiology |
| Source(s) of Funding: | Matching Fund for State Key Laboratory (SKL) |
| Start Date: | 02/2009 |
| Project Title: | Infectivity and Transmissibility Study of Avian H9N2 Influenza Viruses in Pigs |
| Investigator(s): | Guan Y, Zhu H, Wang J |
| Department: | School of Public Health |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 10/2012 |
| Project Title: | Research Output Prize (Li Ka Shing Faculty of Medicine) |
| Investigator(s): | Guan Y |
| Department: | School of Public Health |
| Source(s) of Funding: | Research Output Prize (in Faculty) |
| Start Date: | 01/2013 |
| Project Title: | Active influenza surveillance in poultry and humans focused on Guangdong and Zhejiang Provinces |
| Investigator(s): | Guan Y, Zhu H |
| Department: | School of Public Health |
| Source(s) of Funding: | Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential |
| Start Date: | 06/2014 |
| Researcher : HO CC |
| List of Research Outputs |
| HO C.C., Lau S.K.P. and Woo P.C.Y., Romance of the Three Domains: how cladistics transformed the classification of cellular organisms, Protein & Cell . 2013, 4: 664-676. |
| Teng L.L., HO C.C., Yeung R.S.Y., Wong Y.P., Wang H., Chen C., Fung K.S.C., Lau S.K.P. and Woo P.C.Y., Evaluation of 16SpathDB 2.0, an automated 16S rRNA gene sequence database, using 689 complete bacterial genomes, Diagnostic Microbiology and Infectious Disease. 2014, 78: 105-115. |
| Researcher : HUANG X |
| List of Research Outputs |
| Song W., Wang P., Chen Y., Yang S., Wu N., Lau S.Y., Wu W.L., Mok B.W.Y., Cui D., Huo Z., Zheng M., Huang X., Li L., Yuen K.Y. and Chen H., Mammalian adaptation markers in avian-origin H7N9 virus, a comprehensive investigation in isolates and clinical specimens from the H7N9 influenza affected area, VIII Options for the control of influenza, Cape Town, South Africa, September 2013. |
| WEN X., HUANG X., Mok B.W.Y., Chen Y.X., ZHENG M., Lau S.Y., Wang P., Song W., Jin D., Yuen K.Y. and Chen H., NF90 Exerts Antiviral Activity through Regulation of PKR Phosphorylation and Stress Granules in Infected Cells, Journal of Immunology. 2014, 192(8): 3753-3764. |
| Researcher : Ho PL |
| Project Title: | A phenotypic and genotypic analysis of vancomycin tolerance in Streptococcus pnemoniae |
| Investigator(s): | Ho PL, Yuen KY, Que TL |
| Department: | Microbiology |
| Source(s) of Funding: | Low Budget High Impact Programme |
| Start Date: | 11/2000 |
| Project Title: | Molecular epidemiology of fluoroquinolone-resistant streptococcus pneumoniae in Hong kong and Canada |
| Investigator(s): | Ho PL |
| Department: | Microbiology |
| Source(s) of Funding: | Low Budget High Impact Programme |
| Start Date: | 11/2001 |
| Project Title: | Risk factors for SARS in health care workers following incubation of SARS patients |
| Investigator(s): | Ho PL, Hung CT |
| Department: | Microbiology |
| Source(s) of Funding: | VCO SARS Research Fund |
| Start Date: | 07/2003 |
| Project Title: | Fluoroquinolone susceptibility clinical breakpoints and fluoroquinolone-resistant determining mutations among clinical strains of streptococcus pneumoniae |
| Investigator(s): | Ho PL, Wong SSY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Project Title: | Evaluation of molecular tests for the rapid detection of rifampicin and isoniazid resistance in Mycobacterium tuberculosis and their impact on patient management |
| Investigator(s): | Ho PL, Yam WC, Leung CC, Yew WW, Mok YW, Chan KS, Tam CM |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 04/2006 |
| Project Title: | Syndromic Surveillance and Modeling for Infectious Diseases |
| Investigator(s): | Ho PL, Wu JTK |
| Department: | Microbiology |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 06/2013 |
| List of Research Outputs |
| Chan J., Lo W.U., Chow K.H., Lai E.L.Y., Law P.Y.T. and Ho P.L., Clonal Diversity Of Escherichia Coli Carrying Plasmid-mediated Fosfomycin Resistance Fosa3 From Livestock And Other Animals, Antimicrob Agents Chemother.. US, ASM, 2014. |
| Chan K.H., To K.K.W., Chan J.F.W., Li P.Y., Chan K.M., Chen H., Ho P.L. and Yuen K.Y., Assessment of Antigen and Molecular Tests with Serial Specimens from a Patient with Influenza A(H7N9) Infection, Journal of Clinical Microbiology. 2014, 52(6): 2272-2274. |
| Chen J.H.K., Yam W.C., Ngan A.H.Y., Fung A.M.Y., Woo W.L., Yan M.K., Choi G.K.Y., Ho P.L., Cheng V.C.C. and Yuen K.Y., Advantages of Using Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry as a Rapid Diagnostic Tool for Identification of Yeasts and Mycobacteria in the Clinical Microbiological Laboratory, Journal of Clinical Microbiology. 2013, 51: 3981-3987. |
| Cheng V.C.C., Tai J.W.M., Chau P.H., Chen J.H.K., Yan M.K., So S.Y.C., To K.K.W., Chan J.F.W., Wong S.C.Y., Ho P.L. and Yuen K.Y., Minimal intervention for controlling nosocomial transmission of Methicillin-Resistant Staphylococcus aureus in resource limited setting with high endemicity, PLoS One. 2014, 9: e100493. |
| Cheng V.C.C., Tai J.W.M., Chen J.H.K., So S.Y., Ng W.C., Hung I.F.N., Leung S.S., Wong S.C.Y., Chan T.C., Chan F.H., Ho P.L. and Yuen K.Y., Proactive infection control measures to prevent nosocomial transmission of vancomycin-resistant enterococci in Hong Kong.ournal of the Formosan Medical Association, Journal of the Formosan Medical Association. 2014. |
| Ho P.L., Chau P.H., Yan M.K., Chow K.H., Chen J.H.K., Wong S.C.Y. and Cheng V.C.C., High burden of extended-spectrum β-lactamase-positive Escherichia coli in geriatric patients, Journal of Medical Microbiology. 2014, 63: 878-883. |
| Ho P.L., CHEUNG Y.Y., Lo W.U., LI Z., Chow K.H., Lin C., Chan J.F.W. and Cheng V.C.C., Molecular Characterization of an Atypical IncX3 Plasmid pKPC-NY79 Carrying bla KPC-2 in a Klebsiella pneumoniae. , Current Microbiology. 2013. |
| Ho P.L., Chan J., Lo W.U., Lai E.L.Y., CHEUNG Y.Y., Terrence L.A.U. and Chow K.H., Prevalence and molecular epidemiology of plasmid-mediated fosfomycin resistance genes among blood and urinary Escherichia coli isolates, J Med Microbiol. UK, 2013, 62: 1707-1713. |
| Ho P.L., Lai E.L.Y., Chan P.Y., Lo W.U. and Chow K.H., Rare occurrence of vancomycin-resistant Enterococcus faecium among livestock animals in China. , The Journal of antimicrobial chemotherapy. 2013. |
| Ho P.L., Lo W.U., Chan J., CHEUNG Y.Y., Chow K.H., Yam W.C., Lin C. and Que T.L., pIMP-PH114 carrying bla IMP-4 in a Klebsiella pneumoniae strain is closely related to other multidrug-resistant IncA/C2 plasmids., Current Microbiology. Springer US, 2014, 68(2): 227-232. |
| Lo W.U., Chow K.H., LAW Y.T., NG K.Y., CHEUNG Y.Y., Lai E.L.Y. and Ho P.L., Highly conjugative IncX4 plasmids carrying blaCTX-M in Escherichia coli from human and food animals. , Journal of medical microbiology. United Kingdom, 2014, 63: 835-40. |
| Wun Y.T., Lam T.P., Lam K.F., Ho P.L. and Yung W.H.R., Are There Differences in Antibiotic Use Between the Recent-Immigrants from Mainland China and the Local-Born in Hong Kong?, Journal of Immigrant and Minority Health. 2014. |
| Researcher : Ho TY |
| List of Research Outputs |
| Hung I.F.N., Li T.W., To K.K.W., Ho T.Y., Chan J.F.W., Chan K.H. and Yuen K.Y., Efficacy of Combined Influenza and 23-valent Polysaccharide Pneumococcal Vaccines in Chronic Smoker, Pathogenesis of Respiratory Viruses at Keystone Resort, Colorado, USA, 19-24 January 2014. |
| Researcher : Hui PY |
| Project Title: | Role of retinoic acid inducible gene-1, toll-like receptor-3 and -8 in cytokine induction by influenza A H5N1 and pandemic H1N1 viruses in primary human cells |
| Investigator(s): | Hui PY, Peiris JSM, Cheung CY, Chan MCW, Lee MY, Chan WY |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 11/2010 |
| Project Title: | Mechanistic study on the suppression of IL-1beta during highly pathogenic avian influenza H5N1 infection |
| Investigator(s): | Hui PY, Chan MCW |
| Department: | School of Public Health |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2013 |
| Researcher : Im SWK |
| Project Title: | Investigation of community exposure to a novel coronavirus associated with SARS and herd immunity developed among healthy blood donors |
| Investigator(s): | Im SWK, Yam WC |
| Department: | Microbiology |
| Source(s) of Funding: | VCO SARS Research Fund |
| Start Date: | 07/2003 |
| Researcher : Ip WCT |
| List of Research Outputs |
| To K.K.W., Zhou J., Song Y., Hung I.F.N., Ip W.C.T., Cheng Z., Chan S.F., Kao R.Y.T., Wu A.K.L., Chau S.S., Luk W.K., Ip M.S.M., Chan K.H. and Yuen K.Y., Surfactant protein B gene polymorphism is associated with severe influenza., Chest. 2014, 145(6): 1237-1243. |
| Researcher : KANG Y |
| List of Research Outputs |
| ZHOU J., Cheung K.L.A., Liu H., TAN Z., TANG X., KANG Y., Du Y., Wang H., Liu L. and Chen Z., Potentiating Functional Antigen-specific CD8+ T Cell Immunity by a Novel PD1 Isoform-based Fusion DNA Vaccine, Molecular Therapy. 2013, 21: 1445-1455. |
| Researcher : Kao RYT |
| Project Title: | Mode of action of a lead anti-influenza compound identified by chemical genetics |
| Investigator(s): | Kao RYT |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2006 |
| Project Title: | Cloning and characterization of Streptococcus pneumoniae methionine aminopeptidase: a potential target for antimicrobial therapies |
| Investigator(s): | Kao RYT |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2007 |
| Project Title: | Mechanism of novel antagonists of influenza A nucleoprotein trafficking: A chemical genetics approach |
| Investigator(s): | Kao RYT, Chen H, Yang D, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2011 |
| Completion Date: | 12/2013 |
| Project Title: | Direct binding of influenza A nuceloprotein (NP) to a novel NP nuclear export inhibitor |
| Investigator(s): | Kao RYT, Sze KH |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| List of Research Outputs |
| Chan J.F.W., Chan K.H., Kao R.Y.T., To K.K.W., Zheng B., Li P.Y., Li T.W., Dai J., Mok K.Y., Chen H., Hayden F.G. and Yuen K.Y., Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus., Journal of Infection. 2013, 67(6): 606-16. |
| Sun Y., Tsui Y.K., Masuda K.D.K., Kao R.Y.T., Chan D., Cheung K.M.C. and Leung Y.L.V., Intervening Intervertebral Disc Degeneration By Small Molecules That Positively Modulate Proteoglycan Production, 60th Annual Meeting of Orthopaedic Research Society, 15-18 Mar 2014, New Orleans, USA. 2014. |
| To K.K.W., Zhou J., Song Y., Hung I.F.N., Ip W.C.T., Cheng Z., Chan S.F., Kao R.Y.T., Wu A.K.L., Chau S.S., Luk W.K., Ip M.S.M., Chan K.H. and Yuen K.Y., Surfactant protein B gene polymorphism is associated with severe influenza., Chest. 2014, 145(6): 1237-1243. |
| Wong S.S.W., Kao R.Y.T., Yuen K.Y., Wang Y., Yang D., Samaranayake L.P. and Seneviratne C.J., In vitro and In vivo activity of a novel antifungal small molecule against Candida infections, PloS one. 2014, 9(1): e85836. |
| Wong S.S.W., Seneviratne C.J., Kao R.Y.T., Yang D., Vizcaino J.A., Alpi E., Egusa H. and Samaranayake L.P., Proposed mechanism of a novel small molecule antifungal for Candida , 2014 IADR General Session. 2014. |
| Yang E., Wang G., Woo P.C.Y., Lau S.K.P., Chow W.N., Chong T.K., Tse H., Kao R.Y.T., Chan C.M., Che X., Yuen K.Y. and Cai J.J., Unraveling the molecular basis of temperature-dependent genetic regulation in Penicillium marneffei, Eukaryotic Cell . 2013, 12: 1214-1224. |
| Researcher : Ke Y |
| List of Research Outputs |
| Tse M.K., Cheung K.K., Ke Y., Lau C.Y., Sze K.H. and Yuen K.Y., Backbone and side-chain ¹H, ¹³C and ¹⁵N assignments of the PPIase domain of macrophage infectivity potentiator (Mip) protein from Coxiella burnetii., Biomolecular NMR assignments. 2014, 8(1): 173-176. |
| Researcher : LAW YT |
| List of Research Outputs |
| Lo W.U., Chow K.H., LAW Y.T., NG K.Y., CHEUNG Y.Y., Lai E.L.Y. and Ho P.L., Highly conjugative IncX4 plasmids carrying blaCTX-M in Escherichia coli from human and food animals. , Journal of medical microbiology. United Kingdom, 2014, 63: 835-40. |
| Researcher : LEUNG HC |
| List of Research Outputs |
| Wu R., Li X., LEUNG H.C., Cao Z., Qiu Z., Zhou Y., Zheng B. and He Y., A novel neutralizing antibody against diverse clades of H5N1 influenza virus and its mutants capable of airborne transmission., Antiviral Research . 2014, 106: 13-23. |
| ZHANG N., LIN Y., Chen M., LEUNG H.C., Chan C.S., Poon K.M., Zhou J., Cheung C.Y., Lu L. and Zheng B., Pandemic A/H1N1 2009 Influenza Virus-like Particles Elicited Higher and Broader Immune Responses than the Commercial Panenza Vaccine., J Pharm Pharmaco. 2014, 2(2014): 50-58. |
| Researcher : LI Z |
| List of Research Outputs |
| Ho P.L., CHEUNG Y.Y., Lo W.U., LI Z., Chow K.H., Lin C., Chan J.F.W. and Cheng V.C.C., Molecular Characterization of an Atypical IncX3 Plasmid pKPC-NY79 Carrying bla KPC-2 in a Klebsiella pneumoniae. , Current Microbiology. 2013. |
| Researcher : LIN Y |
| List of Research Outputs |
| ZHANG N., LIN Y., Chen M., LEUNG H.C., Chan C.S., Poon K.M., Zhou J., Cheung C.Y., Lu L. and Zheng B., Pandemic A/H1N1 2009 Influenza Virus-like Particles Elicited Higher and Broader Immune Responses than the Commercial Panenza Vaccine., J Pharm Pharmaco. 2014, 2(2014): 50-58. |
| Researcher : LU X |
| List of Research Outputs |
| Peng Q., Wang H., Wang H., Li X., LU X., Liu L., Zhou B. and Chen Z., Imbalances of Gut-Homing CD4+ T-Cell Subsets in HIV-1–Infected Chinese Patients, JAIDS Journal of Acquired Immune Deficiency Syndromes. 2013, 64: 25-31. |
| Peng Q., Chen Z., Wang H., Li X., LU X., Liu L., Zhou B. and Wang H., Imbalances of gut-homing CD4+ T cell subsets in HIV-1 infected Chinese patients., Journal of Acquired Immune Deficiency Syndromes. 2013, 64(1): 25-31. |
| Researcher : Lai ELY |
| List of Research Outputs |
| Chan J., Lo W.U., Chow K.H., Lai E.L.Y., Law P.Y.T. and Ho P.L., Clonal Diversity Of Escherichia Coli Carrying Plasmid-mediated Fosfomycin Resistance Fosa3 From Livestock And Other Animals, Antimicrob Agents Chemother.. US, ASM, 2014. |
| Ho P.L., Chan J., Lo W.U., Lai E.L.Y., CHEUNG Y.Y., Terrence L.A.U. and Chow K.H., Prevalence and molecular epidemiology of plasmid-mediated fosfomycin resistance genes among blood and urinary Escherichia coli isolates, J Med Microbiol. UK, 2013, 62: 1707-1713. |
| Ho P.L., Lai E.L.Y., Chan P.Y., Lo W.U. and Chow K.H., Rare occurrence of vancomycin-resistant Enterococcus faecium among livestock animals in China. , The Journal of antimicrobial chemotherapy. 2013. |
| Lo W.U., Chow K.H., LAW Y.T., NG K.Y., CHEUNG Y.Y., Lai E.L.Y. and Ho P.L., Highly conjugative IncX4 plasmids carrying blaCTX-M in Escherichia coli from human and food animals. , Journal of medical microbiology. United Kingdom, 2014, 63: 835-40. |
| Researcher : Lam SF |
| List of Research Outputs |
| Lau S.K.P., Li K.S.M., Tsang K.L., Lam S.F., Ahmed S.S., Chen H., Chan K.H., Woo P.C.Y. and Yuen K.Y., Genetic Characterization of Betacoronavirus Lineage C Viruses in Bats Reveals Marked Sequence Divergence in the Spike Protein of Pipistrellus Bat Coronavirus HKU5 in Japanese Pipistrelle: Implications for the Origin of the Novel Middle East Respiratory Syndrome Coronavirus, Journal of Virology. 2013, 87: 8638-8650. |
| Woo P.C.Y., Lau S.K.P., Lam S.F., Tsang K.L., Hui S.W., Fan Y.Y., Martelli P. and Yuen K.Y., Discovery of a novel bottlenose dolphin coronavirus reveals a distinct species of marine mammal coronavirus in Gammacoronavirus, Journal of Virology . 2014, 88: 1318-1331. |
| Researcher : Lam TH |
| List of Research Outputs |
| LAN Y., Lam T.H., Siu G.K.H., Yam W.C., Mason A.J. and Lam J.K.W., In vitro and ex vivo activity of D-antimicrobial peptides against drug resistant mycobacterium tuberculosis, 18th Research Postgraduate Symposium, December 11-12, 2013, Hong Kong. 2013. |
| To W.C.S., Chen J.H.K., Wong K.H., Chan K.C.W., Ng H.M., Wu H., Lam T.H. and Yam W.C., Performance comparison of an in-house integrase genotyping assay versus the ViroSeq (TM) Integra48, and study of HIV-1 integrase polymorphisms in Hong Kong, In: To SW, Chen JH, Wong KH, Chan KC, Ng HM, Wu H, Lam JT, Yam WC, J Clin Virol. 2013, 58(1): 299-302. |
| Researcher : Lau CY |
| List of Research Outputs |
| Chu H., Zhou J., Wong H.Y.B., Li C., Cheng Z., Lin X., Poon K.M., Sun T., Lau C.Y., Chan J.F.W., To K.K.W., Chan K.H., Lu L., Zheng B. and Yuen K.Y., Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response. , Virology. 2014, 454-455: 197-205. |
| Lau S.K.P., Lau C.Y., Chan K.H., Li P.Y., Chen H., Jin D., Chan J.F.W., Woo P.C.Y. and Yuen K.Y., Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment, Journal of General Virology. 2013, 94: 2679-2690. |
| Lau S.K.P., Woo P.C.Y., WU Y., WONG Y.P., Wong B.H.L., Lau C.Y., Fan Y.Y., Cai J., Tsoi H.W., Chan K.H. and Yuen K.Y., Identification and characterization of a novel paramyxovirus, porcine parainfluenza 1 virus, from deceased pigs, Journal of General Virology. 2013, 94: 2184-2190. |
| Lau S.K.P., Tse H., CHAN S.Y.J., Zhou A.C., Curreem S.O.T., Lau C.Y., Yuen K.Y. and Woo P.C.Y., Proteome profiling of the dimorphic fungus Penicillium marneffei extracellular proteins and identification of glyceraldehyde-3-phosphate dehydrogenase as an important adhesion factor for conidial attachment, FEBS Journal . 2013, 280: 6613-6626. |
| Tse M.K., Cheung K.K., Ke Y., Lau C.Y., Sze K.H. and Yuen K.Y., Backbone and side-chain ¹H, ¹³C and ¹⁵N assignments of the PPIase domain of macrophage infectivity potentiator (Mip) protein from Coxiella burnetii., Biomolecular NMR assignments. 2014, 8(1): 173-176. |
| Woo P.C.Y., Lau S.K.P., Wernery U., Wong Y.M., Tsang K.L., Johnson B., Yip C.Y., Lau C.Y., Sivakumar S., Cai J., Fan Y.Y., Chan K.H., Mareena R. and Yuen K.Y., Novel betacoronavirus in dromedaries of the Middle East, 2013, Emerging Infectious Diseases. 2014, 20: 560-572. |
| Zhou J., Chu H., Li C., Wong H.Y.B., Cheng Z., Poon K.M., Sun T., Lau C.Y., Wong K.K., Chan J.Y.K., Chan J.F.W., To K.K.W., Chan K.H., Zheng B. and Yuen K.Y., Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis., J Infect Dis. 2014, 209(9): 1331-42. |
| Researcher : Lau S.K.P. |
| Project Title: | The role of bats in the origin of severe acute respiratory syndrome coronavirus |
| Investigator(s): | Lau SKP, Woo PCY, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 07/2007 |
| Project Title: | Genomic and serological characterization of novel animal paramyxoviruses |
| Investigator(s): | Lau SKP, Woo PCY, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2011 |
| Project Title: | Phenotypic and molecular characterization of a novel Streptococcus species associated with wound infection |
| Investigator(s): | Lau SKP, Woo PCY, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2012 |
| Completion Date: | 12/2013 |
| Project Title: | Matrix-assisted laser desorption ionization time-of-flight mass spectrometry for identification of bacteria that are difficult to identify in clinical laboratories |
| Investigator(s): | Lau SKP, Woo PCY, Teng LL |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2013 |
| Project Title: | Molecular diversity and evolution of bat group C betacoronaviruses: implications on the origin of the novel human group C betacoronavirus |
| Investigator(s): | Lau SKP, Woo PCY, Zheng B |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 09/2013 |
| Project Title: | Molecular evolution and diversity of human coronavirus 229E associated with respiratory tract infections |
| Investigator(s): | Lau SKP, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2014 |
| Project Title: | Infectious diseases of bats symposium ; Bat coronaviruses: diversity, evolution and interspecies transmission |
| Investigator(s): | Lau SKP |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2014 |
| List of Research Outputs |
| Researcher : Lau SKP |
| Project Title: | The role of bats in the origin of severe acute respiratory syndrome coronavirus |
| Investigator(s): | Lau SKP, Woo PCY, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 07/2007 |
| Project Title: | Genomic and serological characterization of novel animal paramyxoviruses |
| Investigator(s): | Lau SKP, Woo PCY, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2011 |
| Project Title: | Phenotypic and molecular characterization of a novel Streptococcus species associated with wound infection |
| Investigator(s): | Lau SKP, Woo PCY, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2012 |
| Completion Date: | 12/2013 |
| Project Title: | Matrix-assisted laser desorption ionization time-of-flight mass spectrometry for identification of bacteria that are difficult to identify in clinical laboratories |
| Investigator(s): | Lau SKP, Woo PCY, Teng LL |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2013 |
| Project Title: | Molecular diversity and evolution of bat group C betacoronaviruses: implications on the origin of the novel human group C betacoronavirus |
| Investigator(s): | Lau SKP, Woo PCY, Zheng B |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 09/2013 |
| Project Title: | Molecular evolution and diversity of human coronavirus 229E associated with respiratory tract infections |
| Investigator(s): | Lau SKP, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2014 |
| Project Title: | Infectious diseases of bats symposium ; Bat coronaviruses: diversity, evolution and interspecies transmission |
| Investigator(s): | Lau SKP |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2014 |
| List of Research Outputs |
| Chan J.F.W., Teng L.L., Li W.S., Wong S.C.Y., Leung S.S.M., Ho P.O., To K.K.W., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Fatal empyema thoracis caused by Schizophyllum commune with cross-reactive cryptococcal antigenemia, Journal of Clinical Microbiology . 2014, 52: 683-687. |
| Chan J.F.W., Lau S.K.P., Wong S.C.Y., To K.K.W., Cheng V.C.C., Yuen K.Y. and Woo P.C.Y., Ten-year retrospective case series of patients with galactomannan antigenemia: implications on the use of serum galactomannan antigen in the diagnosis of invasive and non-invasive aspergillosis, ECCMID 2014, European Society of Clinical Microbiology and Infectious Diseases. 2014. |
| Chan J.F.W., Lau S.K.P. and Woo P.C.Y., The emerging novel Middle East Respiratory Syndrome Coronavirus: the “knowns” and “unknowns”. , Journal of Formosan Medical Association. 2013, 112: 372-381. |
| Cheng V.C.C., Wong S.C.Y., Sridhar S., Chan J.F.W., Ng M.L.M., Lau S.K.P., Woo P.C.Y., Lo E.C.M., Chan K.K.C. and Yuen K.Y., Management of an incident of failed sterilization of surgical instruments in a dental clinic in Hong Kong, Journal of the Formosan Medical Association. 2013, 112: 666-675. |
| HO C.C., Lau S.K.P. and Woo P.C.Y., Romance of the Three Domains: how cladistics transformed the classification of cellular organisms, Protein & Cell . 2013, 4: 664-676. |
| Lau S.K.P., Bat coronaviruses: diversity, evolution and interspecies transmission, Bat Infectious Disease Symposium 2014. (Fort Collins, Colorado, USA). 2014. |
| Lau S.K.P., Woo P.C.Y., Yip C.Y., BAI R., WU Y., Tse H. and Yuen K.Y., Complete genome sequence of a novel feline astrovirus from domestic cat in Hong Kong, Genome Announcements . 2013, 1: e00708-13. |
| Lau S.K.P., Lau C.Y., Chan K.H., Li P.Y., Chen H., Jin D., Chan J.F.W., Woo P.C.Y. and Yuen K.Y., Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment, Journal of General Virology. 2013, 94: 2679-2690. |
| Lau S.K.P., Li K.S.M., Tsang K.L., Lam S.F., Ahmed S.S., Chen H., Chan K.H., Woo P.C.Y. and Yuen K.Y., Genetic Characterization of Betacoronavirus Lineage C Viruses in Bats Reveals Marked Sequence Divergence in the Spike Protein of Pipistrellus Bat Coronavirus HKU5 in Japanese Pipistrelle: Implications for the Origin of the Novel Middle East Respiratory Syndrome Coronavirus, Journal of Virology. 2013, 87: 8638-8650. |
| Lau S.K.P., Woo P.C.Y., WU Y., WONG Y.P., Wong B.H.L., Lau C.Y., Fan Y.Y., Cai J., Tsoi H.W., Chan K.H. and Yuen K.Y., Identification and characterization of a novel paramyxovirus, porcine parainfluenza 1 virus, from deceased pigs, Journal of General Virology. 2013, 94: 2184-2190. |
| Lau S.K.P., Chow W.N., Wong Y.P., Yeung M.Y., Bao Y., Zhang N., Lok S., Woo P.C.Y. and Yuen K.Y., Identification of MicroRNA-like RNAs in Mycelial and yeast phases of the thermal dimorphic fungus Penicillium marneffei, PLoS Neglected Tropical Diseases. 2013, 7: e2398. |
| Lau S.K.P., Tang B.S.F., Teng L.L., Chan T.M., Curreem S.O.T., Fan Y.Y., Ng R.H.Y., Chan J.F.W., Yuen K.Y. and Woo P.C.Y., Matrix-assisted laser desorption ionisation time-of-flight mass spectrometry for identification of clinically significant bacteria that are difficult to identify in clinical laboratories, Journal of Clinical Pathology . 2014, 67: 361-366. |
| Lau S.K.P., Tse H., CHAN S.Y.J., Zhou A.C., Curreem S.O.T., Lau C.Y., Yuen K.Y. and Woo P.C.Y., Proteome profiling of the dimorphic fungus Penicillium marneffei extracellular proteins and identification of glyceraldehyde-3-phosphate dehydrogenase as an important adhesion factor for conidial attachment, FEBS Journal . 2013, 280: 6613-6626. |
| Lau S.K.P., Curreem S.O.T., Lin C.C.N., Fung A.M.Y., Yuen K.Y. and Woo P.C.Y., Streptococcus hongkongensis sp. nov., isolated from a patient with an infected puncture wound and from a marine flatfish., International Journal of Systematic and Evolutionary Microbiology. 2013, 63: 2570-2576. |
| Leung S.Y., Huang Y., Lau S.K.P. and Woo P.C.Y., Complete mitochondrial genome sequence of Lichtheimia ramosa (syn. Lichtheimia hongkongensis), Genome Announcements . 2014, 2: e00644-14. |
| Tam W.T., Chen J.H.K., Lau E.C.L., Ngan A.H.Y., Fung K.S.C., Lee K.C., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Misidentification of Aspergillus nomius and Aspergillus tamarii as Aspergillus flavus: Characterization by Internal Transcribed Spacer, -Tubulin, and Calmodulin Gene Sequencing, Metabolic Fingerprinting, and Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry, In: Tam EW, Chen JH, Lau EC, Ngan AH, Fung KS, Lee KC, Lam CW, Yuen KY, Lau SK, Woo PC, Journal of Clinical Microbiology. 2014, 52: 1153-1160. |
| Tam W.T., Chen J.H.K., Lau E.C., Ngan A.H., Fung K.S., Lee K.C., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Misidentification of Aspergillus nomius and Aspergillus tamarii as Aspergillus flavus: characterization by internal transcribed spacer, β-Tubulin, and calmodulin gene sequencing, metabolic fingerprinting, and matrix-assisted laser desorption ionization-time of flight mass spectrometry, In: Tam EW, Chen JH, Lau EC, Ngan AH, Fung KS, Lee KC, Lam CW, Yuen KY, Lau SK, Woo PC, J Clin Microbiol. 2014. |
| Tang B.S.F., Lau S.K.P., Teng L.L., Chan T.M., Chan W.S., Wong T.Y., Tong Y.T., Fan Y.Y., Yuen K.Y. and Woo P.C.Y., Matrix-assisted laser desorption ionisation-time of flight mass spectrometry for rapid identification of Laribacter hongkongensis, Journal of Clinical Pathology . 2013, 66: 1081-1083. |
| Teng L.L., HO C.C., Yeung R.S.Y., Wong Y.P., Wang H., Chen C., Fung K.S.C., Lau S.K.P. and Woo P.C.Y., Evaluation of 16SpathDB 2.0, an automated 16S rRNA gene sequence database, using 689 complete bacterial genomes, Diagnostic Microbiology and Infectious Disease. 2014, 78: 105-115. |
| Tse C.W.S., Curreem S.O.T., Cheung I., Tang B.S.F., Leung K.W., Lau S.K.P. and Woo P.C.Y., Novel MLST sequence type clustered with other sequence types of human isolates discovered in first fatal case of Laribacter hongkongensis bacteremia, Emerging Microbes and Infections . 2014, 3: e41. |
| Woo P.C.Y., Lau S.K.P., Lam S.F., Tsang K.L., Hui S.W., Fan Y.Y., Martelli P. and Yuen K.Y., Discovery of a novel bottlenose dolphin coronavirus reveals a distinct species of marine mammal coronavirus in Gammacoronavirus, Journal of Virology . 2014, 88: 1318-1331. |
| Woo P.C.Y., Lau S.K.P., Teng L.L., Tsang K.L., Joseph M., Wong Y.M., TANG Y., Sivakumar S., Xie J., BAI R., Wernery R., Wernery U. and Yuen K.Y., New hepatitis E virus genotype in camel, the Middle East, Emerging Infectious Diseases . 2014, 20: 1044-1048. |
| Woo P.C.Y., Lau S.K.P., Wernery U., Wong Y.M., Tsang K.L., Johnson B., Yip C.Y., Lau C.Y., Sivakumar S., Cai J., Fan Y.Y., Chan K.H., Mareena R. and Yuen K.Y., Novel betacoronavirus in dromedaries of the Middle East, 2013, Emerging Infectious Diseases. 2014, 20: 560-572. |
| Xiong L., Teng L.L., Watt R.M., Kan B.I.A.O., Lau S.K.P. and Woo P.C.Y., Arginine deiminase pathway is far more important than urease for acid resistance and intracellular survival in Laribacter hongkongensis: a possible result of arc gene cassette duplication., BMC microbiology. 2014, 14http://www.biomedcentral.com/1471-2180/14/42. |
| Yang E., Wang G., Woo P.C.Y., Lau S.K.P., Chow W.N., Chong T.K., Tse H., Kao R.Y.T., Chan C.M., Che X., Yuen K.Y. and Cai J.J., Unraveling the molecular basis of temperature-dependent genetic regulation in Penicillium marneffei, Eukaryotic Cell . 2013, 12: 1214-1224. |
| Yip C.Y., Lau S.K.P., Lo J.Y.C., Chan K.H., Woo P.C.Y. and Yuen K.Y., Genetic characterization of EV71 isolates from 2004 to 2010 reveals predominance and persistent circulation of the newly proposed genotype D and recent emergence of a distinct lineage of subgenotype C2 in Hong Kong, Virology Journal. 2013, 10: 222. |
| Yip C.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Human enterovirus 71 epidemics: what's next?, Emerging Health Threats Journal. 2013, 6: 19780. |
| Yip C.Y., Lau S.K.P., Woo P.C.Y., Wong S.S.Y., Tsang T.H.F., Lo J.Y.C., Lam W.K., Tsang C.C., Chan K.H. and Yuen K.Y., Recombinant Coxsackievirus A2 and Deaths of Children, Hong Kong, 2012, Emerging Infectious Diseases. 2013, 19: 1285-1288. |
| Researcher : Lau SY |
| List of Research Outputs |
| Song W., Wang P., Chen Y., Yang S., Wu N., Lau S.Y., Wu W.L., Mok B.W.Y., Cui D., Huo Z., Zheng M., Huang X., Li L., Yuen K.Y. and Chen H., Mammalian adaptation markers in avian-origin H7N9 virus, a comprehensive investigation in isolates and clinical specimens from the H7N9 influenza affected area, VIII Options for the control of influenza, Cape Town, South Africa, September 2013. |
| WEN X., HUANG X., Mok B.W.Y., Chen Y.X., ZHENG M., Lau S.Y., Wang P., Song W., Jin D., Yuen K.Y. and Chen H., NF90 Exerts Antiviral Activity through Regulation of PKR Phosphorylation and Stress Granules in Infected Cells, Journal of Immunology. 2014, 192(8): 3753-3764. |
| Yang S.G., Chen Y., Cui D.W., Yao H.P., Lou J.Z., Huo Z.X., Xie G.L., Yu F., Zheng S.F., Yang Y.D., Zhu Y.X., Lu X.Q., Liu X.L., Lau S.Y., Chan J.F.W., To K.K.W., Yuen K.Y., Chen H. and Li L.J., Avian-Origin Influenza A(H7N9) Infection in Influenza A(H7N9)-Affected Areas of China: A Serological Study, Journal of Infectious Diseases. 2014, 209(2): 265-269. |
| Researcher : Law PYT |
| List of Research Outputs |
| Chan J., Lo W.U., Chow K.H., Lai E.L.Y., Law P.Y.T. and Ho P.L., Clonal Diversity Of Escherichia Coli Carrying Plasmid-mediated Fosfomycin Resistance Fosa3 From Livestock And Other Animals, Antimicrob Agents Chemother.. US, ASM, 2014. |
| Researcher : Lee CY |
| List of Research Outputs |
| Zhang J., Li C., To K.K.W., Zhu H., Lee C.Y., Li C., Chan J.F.W., Hung I.F.N. and Yuen K.Y., Toll-like receptor 7 agonist imiquimod in combination with influenza vaccine expedites and augments humoral immune responses against influenza A(H1N1)pdm09 virus infection in BALB/c mice., Clinical and vaccine immunology. 2014, 21(4): 570-579. |
| Researcher : Lee KC |
| List of Research Outputs |
| Tam W.T., Chen J.H.K., Lau E.C.L., Ngan A.H.Y., Fung K.S.C., Lee K.C., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Misidentification of Aspergillus nomius and Aspergillus tamarii as Aspergillus flavus: Characterization by Internal Transcribed Spacer, -Tubulin, and Calmodulin Gene Sequencing, Metabolic Fingerprinting, and Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry, In: Tam EW, Chen JH, Lau EC, Ngan AH, Fung KS, Lee KC, Lam CW, Yuen KY, Lau SK, Woo PC, Journal of Clinical Microbiology. 2014, 52: 1153-1160. |
| Researcher : Lee MY |
| Project Title: | Direct identification and quantification of host and viral microRNAs after influenza infection using the next generation ultra-high throughput DNA sequencer |
| Investigator(s): | Lee MY, Lok S, Cheung CY |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 05/2009 |
| Researcher : Leung SY |
| List of Research Outputs |
| Leung S.Y., Huang Y., Lau S.K.P. and Woo P.C.Y., Complete mitochondrial genome sequence of Lichtheimia ramosa (syn. Lichtheimia hongkongensis), Genome Announcements . 2014, 2: e00644-14. |
| Researcher : Li C |
| List of Research Outputs |
| Chiang A.K.S., Ling S., Li C., Yuen H., Cheuk K.L.D., Li C. and Li C., Population-based treatment results of hepatoblastoma in children of Hong Kong, 45th Congress of the International Society of Paediatric Oncology. 2013. |
| Chiang A.K.S., Lee V., Yuen H., Li C., Ling S., Cheuk K.L.D. and Lee A.C., Results of a uniform treatment protocol based on the ALCL99 study for anaplastic large cell lymphoma in children and adolescents of Hong Kong, 45th Congress of the International Society of Paediatric Oncology. 2013. |
| Chiang A.K.S., Lee V., Yuen H., Li C., Ling S., Cheuk K.L.D. and Lee A.C., Results of a uniform treatment protocol based on the FAB/LMB96 study for B cell non-hodgkin lymphoma in children and adolescents of Hong Kong, 45th Congress of the International Society of Paediatric Oncology. 2013. |
| Chu H., Zhou J., Wong H.Y.B., Li C., Cheng Z., Lin X., Poon K.M., Sun T., Lau C.Y., Chan J.F.W., To K.K.W., Chan K.H., Lu L., Zheng B. and Yuen K.Y., Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response. , Virology. 2014, 454-455: 197-205. |
| Zhang J., Li C., To K.K.W., Zhu H., Lee C.Y., Li C., Chan J.F.W., Hung I.F.N. and Yuen K.Y., Toll-like receptor 7 agonist imiquimod in combination with influenza vaccine expedites and augments humoral immune responses against influenza A(H1N1)pdm09 virus infection in BALB/c mice., Clinical and vaccine immunology. 2014, 21(4): 570-579. |
| Zhou J., Chu H., Li C., Wong H.Y.B., Cheng Z., Poon K.M., Sun T., Lau C.Y., Wong K.K., Chan J.Y.K., Chan J.F.W., To K.K.W., Chan K.H., Zheng B. and Yuen K.Y., Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis., J Infect Dis. 2014, 209(9): 1331-42. |
| Researcher : Li C |
| List of Research Outputs |
| Chiang A.K.S., Ling S., Li C., Yuen H., Cheuk K.L.D., Li C. and Li C., Population-based treatment results of hepatoblastoma in children of Hong Kong, 45th Congress of the International Society of Paediatric Oncology. 2013. |
| Chiang A.K.S., Lee V., Yuen H., Li C., Ling S., Cheuk K.L.D. and Lee A.C., Results of a uniform treatment protocol based on the ALCL99 study for anaplastic large cell lymphoma in children and adolescents of Hong Kong, 45th Congress of the International Society of Paediatric Oncology. 2013. |
| Chiang A.K.S., Lee V., Yuen H., Li C., Ling S., Cheuk K.L.D. and Lee A.C., Results of a uniform treatment protocol based on the FAB/LMB96 study for B cell non-hodgkin lymphoma in children and adolescents of Hong Kong, 45th Congress of the International Society of Paediatric Oncology. 2013. |
| Chu H., Zhou J., Wong H.Y.B., Li C., Cheng Z., Lin X., Poon K.M., Sun T., Lau C.Y., Chan J.F.W., To K.K.W., Chan K.H., Lu L., Zheng B. and Yuen K.Y., Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response. , Virology. 2014, 454-455: 197-205. |
| Zhang J., Li C., To K.K.W., Zhu H., Lee C.Y., Li C., Chan J.F.W., Hung I.F.N. and Yuen K.Y., Toll-like receptor 7 agonist imiquimod in combination with influenza vaccine expedites and augments humoral immune responses against influenza A(H1N1)pdm09 virus infection in BALB/c mice., Clinical and vaccine immunology. 2014, 21(4): 570-579. |
| Zhou J., Chu H., Li C., Wong H.Y.B., Cheng Z., Poon K.M., Sun T., Lau C.Y., Wong K.K., Chan J.Y.K., Chan J.F.W., To K.K.W., Chan K.H., Zheng B. and Yuen K.Y., Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis., J Infect Dis. 2014, 209(9): 1331-42. |
| Researcher : Li C |
| List of Research Outputs |
| Chiang A.K.S., Ling S., Li C., Yuen H., Cheuk K.L.D., Li C. and Li C., Population-based treatment results of hepatoblastoma in children of Hong Kong, 45th Congress of the International Society of Paediatric Oncology. 2013. |
| Chiang A.K.S., Lee V., Yuen H., Li C., Ling S., Cheuk K.L.D. and Lee A.C., Results of a uniform treatment protocol based on the ALCL99 study for anaplastic large cell lymphoma in children and adolescents of Hong Kong, 45th Congress of the International Society of Paediatric Oncology. 2013. |
| Chiang A.K.S., Lee V., Yuen H., Li C., Ling S., Cheuk K.L.D. and Lee A.C., Results of a uniform treatment protocol based on the FAB/LMB96 study for B cell non-hodgkin lymphoma in children and adolescents of Hong Kong, 45th Congress of the International Society of Paediatric Oncology. 2013. |
| Chu H., Zhou J., Wong H.Y.B., Li C., Cheng Z., Lin X., Poon K.M., Sun T., Lau C.Y., Chan J.F.W., To K.K.W., Chan K.H., Lu L., Zheng B. and Yuen K.Y., Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response. , Virology. 2014, 454-455: 197-205. |
| Zhang J., Li C., To K.K.W., Zhu H., Lee C.Y., Li C., Chan J.F.W., Hung I.F.N. and Yuen K.Y., Toll-like receptor 7 agonist imiquimod in combination with influenza vaccine expedites and augments humoral immune responses against influenza A(H1N1)pdm09 virus infection in BALB/c mice., Clinical and vaccine immunology. 2014, 21(4): 570-579. |
| Zhou J., Chu H., Li C., Wong H.Y.B., Cheng Z., Poon K.M., Sun T., Lau C.Y., Wong K.K., Chan J.Y.K., Chan J.F.W., To K.K.W., Chan K.H., Zheng B. and Yuen K.Y., Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis., J Infect Dis. 2014, 209(9): 1331-42. |
| Researcher : Li J |
| List of Research Outputs |
| CHEN C., ZHANG Y., ZHANG Y., Li J., Tsao G.S.W. and Zhang M., Superior Antitumor Activity of a Novel Bispecific Antibody Cotargeting Human Epidermal Growth Factor Receptor 2 and Type I Insulin-like Growth Factor Receptor, Molecular Cancer Therapeutics. 2013, 13: 90-100. |
| SUN Z., Li J., Shao Y. and Zhang M., A Novel Methodology for Isolating Broadly Neutralizing HIV-1 Human Monoclonal Antibodies, AIDS Vaccine 2013. |
| YANG Z., Li J., YUAN T., Chen L.Q., Lou Q., Ying H. and Zhang M., Elicitation of broadly neutralizing HIV-1 antibodies by guiding the immune responses using primary and secondary immunogens , AIDS Vaccine 2013. |
| YUAN T., Li J. and Zhang M., HIV-1 envelope glycoprotein variable loops are indispensable for envelope structural integrity and virus entry, PLoS One. 2013. |
| ZHANG Y., YUAN T., Li J., Zhang Y., Xu J., Shao Y., Chen Z. and Zhang M., The potential of the human immune system to develop broadly neutralizing HIV-1 antibodies: implications for vaccine development, In: JA Levy, AIDS. 2013, 27: 2529-2539. |
| Researcher : Li KSM |
| List of Research Outputs |
| Lau S.K.P., Li K.S.M., Tsang K.L., Lam S.F., Ahmed S.S., Chen H., Chan K.H., Woo P.C.Y. and Yuen K.Y., Genetic Characterization of Betacoronavirus Lineage C Viruses in Bats Reveals Marked Sequence Divergence in the Spike Protein of Pipistrellus Bat Coronavirus HKU5 in Japanese Pipistrelle: Implications for the Origin of the Novel Middle East Respiratory Syndrome Coronavirus, Journal of Virology. 2013, 87: 8638-8650. |
| Researcher : Li PY |
| List of Research Outputs |
| Chan J.F.W., Chan K.H., Kao R.Y.T., To K.K.W., Zheng B., Li P.Y., Li T.W., Dai J., Mok K.Y., Chen H., Hayden F.G. and Yuen K.Y., Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus., Journal of Infection. 2013, 67(6): 606-16. |
| Chan K.H., To K.K.W., Chan J.F.W., Li P.Y., Chen H. and Yuen K.Y., Analytical Sensitivity of Seven Point-of-Care Influenza Virus Detection Tests and Two Molecular Tests for Detection of Avian Origin H7N9 and Swine Origin H3N2 Variant Influenza A Viruses, Journal of Clinical Microbiology. 2013, 51(9): 3160-3161. |
| Chan K.H., To K.K.W., Chan J.F.W., Li P.Y., Chan K.M., Chen H., Ho P.L. and Yuen K.Y., Assessment of Antigen and Molecular Tests with Serial Specimens from a Patient with Influenza A(H7N9) Infection, Journal of Clinical Microbiology. 2014, 52(6): 2272-2274. |
| Chan T.C.I., Hung I.F.N., Chan K.H., Li P.Y., Li T.W., Luk J.K.H., Chu L.W. and Chan F.H.W., Immunogenicity and Safety of Intradermal Trivalent Influenza Vaccination in Nursing Home Older Adults: A Randomized Controlled Trial., Journal of American Medical Directors Association. 2014. |
| Lau S.K.P., Lau C.Y., Chan K.H., Li P.Y., Chen H., Jin D., Chan J.F.W., Woo P.C.Y. and Yuen K.Y., Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment, Journal of General Virology. 2013, 94: 2679-2690. |
| Researcher : Li TW |
| List of Research Outputs |
| Chan J.F.W., Chan K.H., Kao R.Y.T., To K.K.W., Zheng B., Li P.Y., Li T.W., Dai J., Mok K.Y., Chen H., Hayden F.G. and Yuen K.Y., Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus., Journal of Infection. 2013, 67(6): 606-16. |
| Chan T.C.I., Hung I.F.N., Chan K.H., Li P.Y., Li T.W., Luk J.K.H., Chu L.W. and Chan F.H.W., Immunogenicity and Safety of Intradermal Trivalent Influenza Vaccination in Nursing Home Older Adults: A Randomized Controlled Trial., Journal of American Medical Directors Association. 2014. |
| Researcher : Li WS |
| List of Research Outputs |
| Chan J.F.W., Teng L.L., Li W.S., Wong S.C.Y., Leung S.S.M., Ho P.O., To K.K.W., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Fatal empyema thoracis caused by Schizophyllum commune with cross-reactive cryptococcal antigenemia, Journal of Clinical Microbiology . 2014, 52: 683-687. |
| Researcher : Liu L |
| Project Title: | Early HIV-1 diagnosis using in-house real-time PCR amplification on dried blood spots for men who have sex with men in Hong Kong |
| Investigator(s): | Liu L |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 09/2009 |
| Project Title: | Identification of small molecule HIV-1 inhibitors with distinct new targets |
| Investigator(s): | Liu L |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 02/2012 |
| Project Title: | The role of HIV-1/SIV Nef in immune activation through regulating the expression of PD-1 and delta-PD-1 |
| Investigator(s): | Liu L, Chen Z |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 03/2012 |
| Project Title: | Molecular mechanisms of Nef mediated regulation of PD-1 expression during HIV/SIV infection |
| Investigator(s): | Liu L, Chen Z |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 02/2014 |
| Project Title: | A novel small molecule from natural product as a potential agent for purging HIV-1 from the latent reservoir |
| Investigator(s): | Liu L |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| List of Research Outputs |
| Peng Q., Chen Z., Wang H., Li X., LU X., Liu L., Zhou B. and Wang H., Imbalances of gut-homing CD4+ T cell subsets in HIV-1 infected Chinese patients., Journal of Acquired Immune Deficiency Syndromes. 2013, 64(1): 25-31. |
| Researcher : Lo WU |
| Project Title: | Rapid identification of an epidemic clone ST414 of Vancomycin resistant Enterococcus faecium isolates (VREfm) using a novel PCR-based assay |
| Investigator(s): | Lo WU, Ho PL |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2013 |
| Completion Date: | 05/2014 |
| List of Research Outputs |
| Chan J., Lo W.U., Chow K.H., Lai E.L.Y., Law P.Y.T. and Ho P.L., Clonal Diversity Of Escherichia Coli Carrying Plasmid-mediated Fosfomycin Resistance Fosa3 From Livestock And Other Animals, Antimicrob Agents Chemother.. US, ASM, 2014. |
| Ho P.L., CHEUNG Y.Y., Lo W.U., LI Z., Chow K.H., Lin C., Chan J.F.W. and Cheng V.C.C., Molecular Characterization of an Atypical IncX3 Plasmid pKPC-NY79 Carrying bla KPC-2 in a Klebsiella pneumoniae. , Current Microbiology. 2013. |
| Ho P.L., Chan J., Lo W.U., Lai E.L.Y., CHEUNG Y.Y., Terrence L.A.U. and Chow K.H., Prevalence and molecular epidemiology of plasmid-mediated fosfomycin resistance genes among blood and urinary Escherichia coli isolates, J Med Microbiol. UK, 2013, 62: 1707-1713. |
| Ho P.L., Lai E.L.Y., Chan P.Y., Lo W.U. and Chow K.H., Rare occurrence of vancomycin-resistant Enterococcus faecium among livestock animals in China. , The Journal of antimicrobial chemotherapy. 2013. |
| Ho P.L., Lo W.U., Chan J., CHEUNG Y.Y., Chow K.H., Yam W.C., Lin C. and Que T.L., pIMP-PH114 carrying bla IMP-4 in a Klebsiella pneumoniae strain is closely related to other multidrug-resistant IncA/C2 plasmids., Current Microbiology. Springer US, 2014, 68(2): 227-232. |
| Lo W.U., Chow K.H., LAW Y.T., NG K.Y., CHEUNG Y.Y., Lai E.L.Y. and Ho P.L., Highly conjugative IncX4 plasmids carrying blaCTX-M in Escherichia coli from human and food animals. , Journal of medical microbiology. United Kingdom, 2014, 63: 835-40. |
| Researcher : Mok BWY |
| Project Title: | Exploring the role of influenza A virus NS1 protein in microRNA-induced silencing complex (miRISC) regulation of gene expression |
| Investigator(s): | Mok BWY, Chen H |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 04/2012 |
| Completion Date: | 09/2013 |
| Project Title: | The role of influenza virus NS1 in miR-146a-mediated regulation of the innate immune response |
| Investigator(s): | Mok BWY, Chen H |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2014 |
| List of Research Outputs |
| Song W., Wang P., Chen Y., Yang S., Wu N., Lau S.Y., Wu W.L., Mok B.W.Y., Cui D., Huo Z., Zheng M., Huang X., Li L., Yuen K.Y. and Chen H., Mammalian adaptation markers in avian-origin H7N9 virus, a comprehensive investigation in isolates and clinical specimens from the H7N9 influenza affected area, VIII Options for the control of influenza, Cape Town, South Africa, September 2013. |
| WEN X., HUANG X., Mok B.W.Y., Chen Y.X., ZHENG M., Lau S.Y., Wang P., Song W., Jin D., Yuen K.Y. and Chen H., NF90 Exerts Antiviral Activity through Regulation of PKR Phosphorylation and Stress Granules in Infected Cells, Journal of Immunology. 2014, 192(8): 3753-3764. |
| Researcher : Mok KY |
| List of Research Outputs |
| Chan J.F.W., Chan K.H., Kao R.Y.T., To K.K.W., Zheng B., Li P.Y., Li T.W., Dai J., Mok K.Y., Chen H., Hayden F.G. and Yuen K.Y., Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus., Journal of Infection. 2013, 67(6): 606-16. |
| Liu R., To K.K.W., Teng L.L., Choi K.Y., Mok K.Y., Law K.I., Tso E.Y., Fung K.S., Wu T.C., Wu A.K.L., Fung S.H., Wong S.C.Y., Trendell-Smith N.J. and Yuen K.Y., Mycobacterium abscessus bacteremia after receipt of intravenous infusate of cytokine-induced killer cell therapy for body beautification and health boosting., Clinical infectious diseases. 2013, 57(7): 981-991. |
| Researcher : NG KY |
| List of Research Outputs |
| Lo W.U., Chow K.H., LAW Y.T., NG K.Y., CHEUNG Y.Y., Lai E.L.Y. and Ho P.L., Highly conjugative IncX4 plasmids carrying blaCTX-M in Escherichia coli from human and food animals. , Journal of medical microbiology. United Kingdom, 2014, 63: 835-40. |
| Researcher : Ng HM |
| List of Research Outputs |
| To W.C.S., Chen J.H.K., Wong K.H., Chan K.C.W., Ng H.M., Wu H., Lam T.H. and Yam W.C., Performance comparison of an in-house integrase genotyping assay versus the ViroSeq (TM) Integra48, and study of HIV-1 integrase polymorphisms in Hong Kong, In: To SW, Chen JH, Wong KH, Chan KC, Ng HM, Wu H, Lam JT, Yam WC, J Clin Virol. 2013, 58(1): 299-302. |
| To W.C.S., Chen J.H.K., Wong K.H., Chan K.C.W., Ng H.M., Wu H., Lam J.T. and Yam W.C., Performance comparison of an in-house integrase genotyping assay versus the ViroSeq™ Integra48, and study of HIV-1 integrase polymorphisms in Hong Kong, Journal of Clinical Virology. 2013, 58: 299-302. |
| Researcher : Ng SP |
| Project Title: | Collection of background information on the alternative faecal indicators in the environmental waters of Hong Kong and their correlation with Escherichia coli |
| Investigator(s): | Ng SP, Yam WC |
| Department: | Microbiology |
| Source(s) of Funding: | Environment Protection Department - General Award |
| Start Date: | 06/2001 |
| Researcher : Peiris JSM |
| Project Title: | IV International Symposium on Respiratory Viral Infections The Influenza Disease Burden in Hong Kong: the Rates of Hospitalisation in Children |
| Investigator(s): | Peiris JSM |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2001 |
| Project Title: | Influenza pandemic preparedness in Asia (Research collaboration with national Institute of Allergy and Infectious Diseases (NIAID), St. Jude Children's Research Hospital, Inc. (SJCRH) and The University of Hong Kong) |
| Investigator(s): | Peiris JSM, Guan Y |
| Department: | Microbiology |
| Source(s) of Funding: | National Institutes of Health, US Department of Health and Human Services - General Award |
| Start Date: | 04/2003 |
| Project Title: | Virus-cell interaction and the pathogenesis of SARS |
| Investigator(s): | Peiris JSM |
| Department: | Microbiology |
| Source(s) of Funding: | VCO SARS Research Fund |
| Start Date: | 07/2003 |
| Project Title: | Viral determinants underlying the increased secretion of pro-inflammatory cytokines in H5N1 infected human macrophages: a mechanism for the unusual severity of human H5N1 disease? |
| Investigator(s): | Peiris JSM, Guan Y, Lau ASY, Poon LLM |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2003 |
| Project Title: | The macrophage in the pathogenesis of Severe Acute Respiratory Syndrome Coronavirus infection |
| Investigator(s): | Peiris JSM |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 12/2005 |
| Project Title: | Mass Tag PCR: A novel, multiplex and potentially sensitive approach for the rapid detection of respiratory pathogens |
| Investigator(s): | Peiris JSM, Chiu SSS, Cheung CY |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 06/2006 |
| Project Title: | The pathogenesis of avian influenza A H5N1 in humans: macrophage and epithelial cell-virus interactions in vitro and ex-vivo |
| Investigator(s): | Peiris JSM |
| Department: | Microbiology |
| Source(s) of Funding: | The Wellcome Trust - General Award |
| Start Date: | 01/2007 |
| Project Title: | Communicable Diseases Surveillance and Response (CSR) - Standardization and shipment of PCR diagnostic kit for Avian Influenza detection to Member countries (viz: Bangladesh, Indonesia, Myanmar, Sri Lanka and Thailand) |
| Investigator(s): | Peiris JSM |
| Department: | Microbiology |
| Source(s) of Funding: | Collaborating Project Fund |
| Start Date: | 06/2007 |
| Project Title: | Control of Pandemic and Inter-pandemic Influenza |
| Investigator(s): | Peiris JSM, Guan Y, Yuen KY, Chen H, Leung GM, Lau YL |
| Department: | Microbiology |
| Source(s) of Funding: | Areas of Excellence Scheme |
| Start Date: | 01/2008 |
| Project Title: | Options for the Control of Influenza; Lung injury / ARDS |
| Investigator(s): | Peiris JSM |
| Department: | School of Public Health |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2013 |
| Completion Date: | 09/2013 |
| Project Title: | Host responses that correlate with respiratory droplet transmission of swine-origin influenza viruses in ferrets |
| Investigator(s): | Peiris JSM, Yen H, Nicholls JM |
| Department: | School of Public Health |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 10/2013 |
| Project Title: | Risk assessing human transmission potential of H7N9 viruses using ex vivo cultures of the human respiratory tract |
| Investigator(s): | Peiris JSM, Nicholls JM, Chan MCW, Chan WY, Lai JCC, Mok KP |
| Department: | School of Public Health |
| Source(s) of Funding: | Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential |
| Start Date: | 05/2014 |
| Project Title: | Surveillance of influenza A including subtype H7N9 in outpatients with influenza-like illness and hospitalized patients with severe acute respiratory illness (SARI) presenting at The First Affiliated Hospital of Guangzhou Medical University |
| Investigator(s): | Peiris JSM, Mok KP, Cowling BJ |
| Department: | School of Public Health |
| Source(s) of Funding: | Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential |
| Start Date: | 05/2014 |
| List of Research Outputs |
| Chiu S.S.S., Lo J.Y.C., Chan K.H., Chan L.Y., So L.Y., Wu P., Cowling B.J., Chen H.S.R. and Peiris J.S.M., Population-Based Hospitalization Burden of Influenza A Virus Subtypes and Antigenic Drift Variants in Children in Hong Kong (2004-2011), PLOS One. 2014, 9(4): e92914. |
| Researcher : Poon KM |
| List of Research Outputs |
| Chu H., Zhou J., Wong H.Y.B., Li C., Cheng Z., Lin X., Poon K.M., Sun T., Lau C.Y., Chan J.F.W., To K.K.W., Chan K.H., Lu L., Zheng B. and Yuen K.Y., Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response. , Virology. 2014, 454-455: 197-205. |
| Du L., Zhao G., Kou Z., Ma C., Sun S., Poon K.M., Lu L., Wang L., Debnath A.K., Zhou Y. and Jiang S., Identification of Receptor-Binding Domain in S protein of the Novel Human Coronavirus MERS-CoV as an Essential Target for Vaccine Development., Journal of Virology. 2013, 87(17): 9939-42. |
| Jiang L., Wang N., Zuo T., Shi X., Poon K.M., Wu Y., Gao F., Li D., Wang R., Guo J., Fu L., Yuen K.Y., Zheng B., Wang X. and Zhang L., Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein, Sci Transl Med. 2014, 6(234): 234ra59. |
| ZHANG N., LIN Y., Chen M., LEUNG H.C., Chan C.S., Poon K.M., Zhou J., Cheung C.Y., Lu L. and Zheng B., Pandemic A/H1N1 2009 Influenza Virus-like Particles Elicited Higher and Broader Immune Responses than the Commercial Panenza Vaccine., J Pharm Pharmaco. 2014, 2(2014): 50-58. |
| Zhao G., Du L., Ma C., Li Y., Li L., Poon K.M., Wang L., Yu F., Zheng B., Jiang S. and Zhou Y., A safe and convenient pseudovirus-based inhibition assay to detect neutralizing antibodies and screen for viral entry inhibitors against the novel human coronavirus MERS-CoV., Virology Journal. 2013, 10(1): 266. |
| Zhou J., Chu H., Li C., Wong H.Y.B., Cheng Z., Poon K.M., Sun T., Lau C.Y., Wong K.K., Chan J.Y.K., Chan J.F.W., To K.K.W., Chan K.H., Zheng B. and Yuen K.Y., Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis., J Infect Dis. 2014, 209(9): 1331-42. |
| Researcher : Poon LLM |
| Project Title: | Reverse genetic for a coronavirus responsible for severe acute respiratory syndrome |
| Investigator(s): | Poon LLM, Guan Y |
| Department: | Microbiology |
| Source(s) of Funding: | VCO SARS Research Fund |
| Start Date: | 07/2003 |
| Project Title: | International Conference on Options for Control of Influenza V Genetic Characterization of a Novel Coronavirus Responsible for Severe Acute Respiratory Syndrome A Coronavirus Responsible for Severe Acute Respiratory Syndrome |
| Investigator(s): | Poon LLM |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2003 |
| Project Title: | Centre for Research into Circulating Fetal Nucleic Acids |
| Investigator(s): | Poon LLM |
| Department: | Microbiology |
| Source(s) of Funding: | Areas of Excellence Scheme |
| Start Date: | 01/2008 |
| Project Title: | Retrospective studies of pandemic and seasonal human influenza viral polymerase complexes |
| Investigator(s): | Poon LLM |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2011 |
| Completion Date: | 12/2013 |
| Project Title: | Epigenomic modifications induced by influenza A infection |
| Investigator(s): | Poon LLM, Li OTW |
| Department: | School of Public Health |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2012 |
| Completion Date: | 03/2014 |
| Project Title: | Generation of live attenuated influenza viruses of vaccine potential by using codon usage bias |
| Investigator(s): | Poon LLM |
| Department: | School of Public Health |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 02/2013 |
| Project Title: | Options for the Control of Influenza ; A statistical strategy to identify recombinant viral ribonucleoprotein of avian, human, and swine influenza A viruses with elevated polymerase activity. |
| Investigator(s): | Poon LLM |
| Department: | School of Public Health |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2013 |
| Completion Date: | 09/2013 |
| Project Title: | Characterization of fibronectin-mediated influenza A virus infection in human cells. |
| Investigator(s): | Poon LLM, Chan WY |
| Department: | School of Public Health |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Researcher : Poon WSR |
| List of Research Outputs |
| Wong S.S.Y., Fung K.S., Chau S., Poon W.S.R., Wong S.C.Y. and Yuen K.Y., Molecular diagnosis in clinical parasitology: When and why?, Experimental biology and medicine. 2014. |
| Researcher : SUN Z |
| List of Research Outputs |
| SUN Z., Li J., Shao Y. and Zhang M., A Novel Methodology for Isolating Broadly Neutralizing HIV-1 Human Monoclonal Antibodies, AIDS Vaccine 2013. |
| Researcher : Smith GJ |
| Project Title: | Research into the ecology, evolution and population genetics of influenza A (H5N1) virus |
| Investigator(s): | Smith GJ |
| Department: | Microbiology |
| Source(s) of Funding: | National Institutes of Health, US Department of Health and Human Services - General Award |
| Start Date: | 05/2007 |
| Project Title: | Outstanding Young Researcher Award 2008-2009 |
| Investigator(s): | Smith GJ |
| Department: | Microbiology |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 12/2009 |
| List of Research Outputs |
| Guan Y. and Smith G.J., The emergence and diversification of panzootic H5N1 influenza viruses., Virus Research. 2013, 178(1): 35-43. |
| Researcher : Song W |
| List of Research Outputs |
| Song W., Wang P., Chen Y., Yang S., Wu N., Lau S.Y., Wu W.L., Mok B.W.Y., Cui D., Huo Z., Zheng M., Huang X., Li L., Yuen K.Y. and Chen H., Mammalian adaptation markers in avian-origin H7N9 virus, a comprehensive investigation in isolates and clinical specimens from the H7N9 influenza affected area, VIII Options for the control of influenza, Cape Town, South Africa, September 2013. |
| WEN X., HUANG X., Mok B.W.Y., Chen Y.X., ZHENG M., Lau S.Y., Wang P., Song W., Jin D., Yuen K.Y. and Chen H., NF90 Exerts Antiviral Activity through Regulation of PKR Phosphorylation and Stress Granules in Infected Cells, Journal of Immunology. 2014, 192(8): 3753-3764. |
| Wu H.Z., Song W., Gao X., Liu N., Wang P., Chen H. and Cai Z.W., Proteomics study of N-acetylcysteine response in H1N1-infected cells by using mass spectrometry, Rapid Communications in Mass Spectrometry. 2014, 28(7): 741-749. |
| Researcher : Sridhar S |
| List of Research Outputs |
| Cheng V.C.C., Wong S.C.Y., Sridhar S., Chan J.F.W., Ng M.L.M., Lau S.K.P., Woo P.C.Y., Lo E.C.M., Chan K.K.C. and Yuen K.Y., Management of an incident of failed sterilization of surgical instruments in a dental clinic in Hong Kong, Journal of the Formosan Medical Association. 2013, 112: 666-675. |
| Sridhar S., Chan J.F.W. and Yuen K.Y., First report of brain abscess caused by a satelliting phenotypic variant of Helcococcus kunzii., Journal of clinical microbiology. 2013, 52(1): 370-373. |
| Researcher : Sun T |
| List of Research Outputs |
| Chu H., Zhou J., Wong H.Y.B., Li C., Cheng Z., Lin X., Poon K.M., Sun T., Lau C.Y., Chan J.F.W., To K.K.W., Chan K.H., Lu L., Zheng B. and Yuen K.Y., Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response. , Virology. 2014, 454-455: 197-205. |
| Zhou J., Chu H., Li C., Wong H.Y.B., Cheng Z., Poon K.M., Sun T., Lau C.Y., Wong K.K., Chan J.Y.K., Chan J.F.W., To K.K.W., Chan K.H., Zheng B. and Yuen K.Y., Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis., J Infect Dis. 2014, 209(9): 1331-42. |
| Researcher : Sze KH |
| Project Title: | XXIInd International Conference on Magnetic Resonance in Biological Systems (ICMRBS 2006) Backbone Dynamics and Solution Structure of a Thermophilic Acylphosphatase from Pyrococcus Horikoshii by NMR Spectroscopy |
| Investigator(s): | Sze KH |
| Department: | Chemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2006 |
| Project Title: | Investigation of the binding of cell wall proteins of Penicillium marneffei and Aspergillus fumigates with proinflammatory lipid signaling molecules: A mechanism of pathogen’s evasion of host defense? |
| Investigator(s): | Sze KH, Yuen KY, Kao RYT, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2012 |
| Completion Date: | 04/2014 |
| Project Title: | Investigation of the binding of cell wall proteins of Penicillium marneffei and Aspergillus fumigates with proinflammatory lipid signaling molecules: A mechanism of pathogens evasion of host defense? |
| Investigator(s): | Sze KH, Kao RYT, Woo PCY, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2012 |
| Project Title: | Structure-function study of virulence factor Macrophage Infectivity Potentiator of Coxiella burnetii and Legionella pneumophila |
| Investigator(s): | Sze KH, Yuen KY, Kao RYT |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2013 |
| Project Title: | Host target identification and characterization for the secreted virulence factors ESAT6/CFP10 of Mycobacterium tuberculosis and structure-based screening of ESAT6/CFP10 's inhibitors for combating multi-drug resistant tuberculosis (MDR-TB) |
| Investigator(s): | Sze KH, Yuen KY, Kao RYT |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2014 |
| Project Title: | Characterization of Staphylococcus aureus virulence factor EsxA and structure-based screening of EsxA's inhibitors for combating methicillin-resistant Staphylococcus aureus (MRSA) |
| Investigator(s): | Sze KH, Kao RYT |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2014 |
| List of Research Outputs |
| Lam C.W., Law C.Y., To K.K.W., Cheung K.K., Lee K.C., Sze K.H. and Yuen K.Y., Springer Poster Prize For Outstanding Poster Presentation Of Research In The Field Of Metabolomics In The Metabolomics Society 2013 Conference , Metabolomics Society 2013 Conference . 2013. |
| Tse M.K., Cheung K.K., Ke Y., Lau C.Y., Sze K.H. and Yuen K.Y., Backbone and side-chain ¹H, ¹³C and ¹⁵N assignments of the PPIase domain of macrophage infectivity potentiator (Mip) protein from Coxiella burnetii., Biomolecular NMR assignments. 2014, 8(1): 173-176. |
| WONG K.H., Sze K.H., CHEN T., Cho L.C.K., LAW C.H., Chu I.K. and Wong A.O.L., Goldfish spexin: solution structure and novel function as a satiety factor in feeding control., Am. J. Physiol. Endocrinol. Metab.. 2013, 305(3): E348-E366. |
| Researcher : TAN Z |
| List of Research Outputs |
| ZHOU J., Cheung K.L.A., Liu H., TAN Z., TANG X., KANG Y., Du Y., Wang H., Liu L. and Chen Z., Potentiating Functional Antigen-specific CD8+ T Cell Immunity by a Novel PD1 Isoform-based Fusion DNA Vaccine, Molecular Therapy. 2013, 21: 1445-1455. |
| Researcher : TANG X |
| List of Research Outputs |
| ZHOU J., Cheung K.L.A., Liu H., TAN Z., TANG X., KANG Y., Du Y., Wang H., Liu L. and Chen Z., Potentiating Functional Antigen-specific CD8+ T Cell Immunity by a Novel PD1 Isoform-based Fusion DNA Vaccine, Molecular Therapy. 2013, 21: 1445-1455. |
| Researcher : TANG Y |
| List of Research Outputs |
| Woo P.C.Y., Lau S.K.P., Teng L.L., Tsang K.L., Joseph M., Wong Y.M., TANG Y., Sivakumar S., Xie J., BAI R., Wernery R., Wernery U. and Yuen K.Y., New hepatitis E virus genotype in camel, the Middle East, Emerging Infectious Diseases . 2014, 20: 1044-1048. |
| Researcher : TSANG KL |
| List of Research Outputs |
| Lau S.K.P., Li K.S.M., Tsang K.L., Lam S.F., Ahmed S.S., Chen H., Chan K.H., Woo P.C.Y. and Yuen K.Y., Genetic Characterization of Betacoronavirus Lineage C Viruses in Bats Reveals Marked Sequence Divergence in the Spike Protein of Pipistrellus Bat Coronavirus HKU5 in Japanese Pipistrelle: Implications for the Origin of the Novel Middle East Respiratory Syndrome Coronavirus, Journal of Virology. 2013, 87: 8638-8650. |
| To K.K.W., TSANG K.L., Chan J.F.W., Cheng V.C.C., Chen H. and Yuen K.Y., Emergence in China of human disease due to avian influenza A(H10N8) - Cause for concern?, Journal of Infection. 2014, 68(3): 205-215. |
| Woo P.C.Y., Lau S.K.P., Lam S.F., Tsang K.L., Hui S.W., Fan Y.Y., Martelli P. and Yuen K.Y., Discovery of a novel bottlenose dolphin coronavirus reveals a distinct species of marine mammal coronavirus in Gammacoronavirus, Journal of Virology . 2014, 88: 1318-1331. |
| Woo P.C.Y., Lau S.K.P., Teng L.L., Tsang K.L., Joseph M., Wong Y.M., TANG Y., Sivakumar S., Xie J., BAI R., Wernery R., Wernery U. and Yuen K.Y., New hepatitis E virus genotype in camel, the Middle East, Emerging Infectious Diseases . 2014, 20: 1044-1048. |
| Woo P.C.Y., Lau S.K.P., Wernery U., Wong Y.M., Tsang K.L., Johnson B., Yip C.Y., Lau C.Y., Sivakumar S., Cai J., Fan Y.Y., Chan K.H., Mareena R. and Yuen K.Y., Novel betacoronavirus in dromedaries of the Middle East, 2013, Emerging Infectious Diseases. 2014, 20: 560-572. |
| Researcher : Tai JWM |
| List of Research Outputs |
| Cheng V.C.C., Tai J.W.M., Chau P.H., Chen J.H.K., Yan M.K., So S.Y.C., To K.K.W., Chan J.F.W., Wong S.C.Y., Ho P.L. and Yuen K.Y., Minimal intervention for controlling nosocomial transmission of Methicillin-Resistant Staphylococcus aureus in resource limited setting with high endemicity, PLoS One. 2014, 9: e100493. |
| Cheng V.C.C., Tai J.W.M., Chen J.H.K., So S.Y., Ng W.C., Hung I.F.N., Leung S.S., Wong S.C.Y., Chan T.C., Chan F.H., Ho P.L. and Yuen K.Y., Proactive infection control measures to prevent nosocomial transmission of vancomycin-resistant enterococci in Hong Kong.ournal of the Formosan Medical Association, Journal of the Formosan Medical Association. 2014. |
| Researcher : Tam WT |
| List of Research Outputs |
| Tam W.T., Chen J.H.K., Lau E.C.L., Ngan A.H.Y., Fung K.S.C., Lee K.C., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Misidentification of Aspergillus nomius and Aspergillus tamarii as Aspergillus flavus: Characterization by Internal Transcribed Spacer, -Tubulin, and Calmodulin Gene Sequencing, Metabolic Fingerprinting, and Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry, In: Tam EW, Chen JH, Lau EC, Ngan AH, Fung KS, Lee KC, Lam CW, Yuen KY, Lau SK, Woo PC, Journal of Clinical Microbiology. 2014, 52: 1153-1160. |
| Tam W.T., Chen J.H.K., Lau E.C., Ngan A.H., Fung K.S., Lee K.C., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Misidentification of Aspergillus nomius and Aspergillus tamarii as Aspergillus flavus: characterization by internal transcribed spacer, β-Tubulin, and calmodulin gene sequencing, metabolic fingerprinting, and matrix-assisted laser desorption ionization-time of flight mass spectrometry, In: Tam EW, Chen JH, Lau EC, Ngan AH, Fung KS, Lee KC, Lam CW, Yuen KY, Lau SK, Woo PC, J Clin Microbiol. 2014. |
| Researcher : Teng LL |
| Project Title: | Usefulness of full sequence and 5' end 527-bp 16S ribosomal RNA gene sequencing for identification of medically important aerobic Gram-positive cocci |
| Investigator(s): | Teng LL, Woo PCY, Lau SKP, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2006 |
| Project Title: | The complete genome sequencing of Tsukamurella tyrosinosolvens, a bacterium associated with ophthalmologic infections |
| Investigator(s): | Teng LL, Woo PCY, Lau SKP |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2013 |
| Project Title: | Arginine deiminase pathway is far more important than urease for acid resistance in Laribacter hongkongensis: a possible result of arc gene cassette duplication |
| Investigator(s): | Teng LL, Woo PCY, Lau SKP |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2014 |
| List of Research Outputs |
| Chan J.F.W., Teng L.L., Li W.S., Wong S.C.Y., Leung S.S.M., Ho P.O., To K.K.W., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Fatal empyema thoracis caused by Schizophyllum commune with cross-reactive cryptococcal antigenemia, Journal of Clinical Microbiology . 2014, 52: 683-687. |
| Lau S.K.P., Tang B.S.F., Teng L.L., Chan T.M., Curreem S.O.T., Fan Y.Y., Ng R.H.Y., Chan J.F.W., Yuen K.Y. and Woo P.C.Y., Matrix-assisted laser desorption ionisation time-of-flight mass spectrometry for identification of clinically significant bacteria that are difficult to identify in clinical laboratories, Journal of Clinical Pathology . 2014, 67: 361-366. |
| Liu R., To K.K.W., Teng L.L., Choi K.Y., Mok K.Y., Law K.I., Tso E.Y., Fung K.S., Wu T.C., Wu A.K.L., Fung S.H., Wong S.C.Y., Trendell-Smith N.J. and Yuen K.Y., Mycobacterium abscessus bacteremia after receipt of intravenous infusate of cytokine-induced killer cell therapy for body beautification and health boosting., Clinical infectious diseases. 2013, 57(7): 981-991. |
| Tang B.S.F., Lau S.K.P., Teng L.L., Chan T.M., Chan W.S., Wong T.Y., Tong Y.T., Fan Y.Y., Yuen K.Y. and Woo P.C.Y., Matrix-assisted laser desorption ionisation-time of flight mass spectrometry for rapid identification of Laribacter hongkongensis, Journal of Clinical Pathology . 2013, 66: 1081-1083. |
| Teng L.L., HO C.C., Yeung R.S.Y., Wong Y.P., Wang H., Chen C., Fung K.S.C., Lau S.K.P. and Woo P.C.Y., Evaluation of 16SpathDB 2.0, an automated 16S rRNA gene sequence database, using 689 complete bacterial genomes, Diagnostic Microbiology and Infectious Disease. 2014, 78: 105-115. |
| Woo P.C.Y., Lau S.K.P., Teng L.L., Tsang K.L., Joseph M., Wong Y.M., TANG Y., Sivakumar S., Xie J., BAI R., Wernery R., Wernery U. and Yuen K.Y., New hepatitis E virus genotype in camel, the Middle East, Emerging Infectious Diseases . 2014, 20: 1044-1048. |
| Xiong L., Teng L.L., Watt R.M., Kan B.I.A.O., Lau S.K.P. and Woo P.C.Y., Arginine deiminase pathway is far more important than urease for acid resistance and intracellular survival in Laribacter hongkongensis: a possible result of arc gene cassette duplication., BMC microbiology. 2014, 14http://www.biomedcentral.com/1471-2180/14/42. |
| Researcher : To KKW |
| Project Title: | Rapid detection of macrolide resistance amony Mycoplasma pneumoniae in Queen Mary Hospital |
| Investigator(s): | To KKW, Ho PL, Chan KH, Hung IFN, Chiu SSS |
| Department: | Microbiology |
| Source(s) of Funding: | Queen Mary Hospital Charitable Trust - Training and Research Assistance Scheme |
| Start Date: | 07/2011 |
| Project Title: | Serological study of H7N9, H5N1 and H9N2 influenza among animal handlers |
| Investigator(s): | To KKW, Hung IFN, Yuen KY, Chan JFW |
| Department: | Microbiology |
| Source(s) of Funding: | Centre for Health Protection |
| Start Date: | 09/2013 |
| Project Title: | Identification of innate immune defect predisposing to severe influenza in a Chinese population |
| Investigator(s): | To KKW, Zhou J, Song Y, Hung IFN, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 09/2013 |
| Project Title: | 2014 Keystone Symposia Conference. Pathogenesis of Respiratory Viruses (J5); Surfactant protein B gene polymorphism is associated with severe influenza |
| Investigator(s): | To KKW |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 01/2014 |
| List of Research Outputs |
| Bao S., Zhou X.Y., Zhang L.C., Zhou J., To K.K.W., Wang B., Wang L., Zhang X. and Song Y., Prioritizing genes affecting host resistance to influenza by network approaches, BMC Genomics . 2013, 14(1): 816. |
| Bao S., Zhou X., Zhang L., Zhou J., To K.K.W., Wang B., Wang L., Zhang X. and Song Y., Prioritizing genes responsible for host resistance to influenza using network approaches.BMC genomics, BMC genomics. 2013. |
| Chan J.F.W., Chan K.H., Kao R.Y.T., To K.K.W., Zheng B., Li P.Y., Li T.W., Dai J., Mok K.Y., Chen H., Hayden F.G. and Yuen K.Y., Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus., Journal of Infection. 2013, 67(6): 606-16. |
| Chan J.F.W., Teng L.L., Li W.S., Wong S.C.Y., Leung S.S.M., Ho P.O., To K.K.W., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Fatal empyema thoracis caused by Schizophyllum commune with cross-reactive cryptococcal antigenemia, Journal of Clinical Microbiology . 2014, 52: 683-687. |
| Chan J.F.W., Lau S.K.P., Wong S.C.Y., To K.K.W., Cheng V.C.C., Yuen K.Y. and Woo P.C.Y., Ten-year retrospective case series of patients with galactomannan antigenemia: implications on the use of serum galactomannan antigen in the diagnosis of invasive and non-invasive aspergillosis, ECCMID 2014, European Society of Clinical Microbiology and Infectious Diseases. 2014. |
| Chan K.H., To K.K.W., Chan J.F.W., Li P.Y., Chen H. and Yuen K.Y., Analytical Sensitivity of Seven Point-of-Care Influenza Virus Detection Tests and Two Molecular Tests for Detection of Avian Origin H7N9 and Swine Origin H3N2 Variant Influenza A Viruses, Journal of Clinical Microbiology. 2013, 51(9): 3160-3161. |
| Chan K.H., To K.K.W., Chan J.F.W., Li P.Y., Chan K.M., Chen H., Ho P.L. and Yuen K.Y., Assessment of Antigen and Molecular Tests with Serial Specimens from a Patient with Influenza A(H7N9) Infection, Journal of Clinical Microbiology. 2014, 52(6): 2272-2274. |
| Cheng V.C.C., Chan J.F.W., To K.K.W. and Yuen K.Y., Clinical management and infection control of SARS: lessons learned., Antiviral research. 2013, 100(2): 407-419. |
| Cheng V.C.C., Tai J.W.M., Chau P.H., Chen J.H.K., Yan M.K., So S.Y.C., To K.K.W., Chan J.F.W., Wong S.C.Y., Ho P.L. and Yuen K.Y., Minimal intervention for controlling nosocomial transmission of Methicillin-Resistant Staphylococcus aureus in resource limited setting with high endemicity, PLoS One. 2014, 9: e100493. |
| Chu H., Zhou J., Wong H.Y.B., Li C., Cheng Z., Lin X., Poon K.M., Sun T., Lau C.Y., Chan J.F.W., To K.K.W., Chan K.H., Lu L., Zheng B. and Yuen K.Y., Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response. , Virology. 2014, 454-455: 197-205. |
| Hung I.F.N., Li T.W., To K.K.W., Ho T.Y., Chan J.F.W., Chan K.H. and Yuen K.Y., Efficacy of Combined Influenza and 23-valent Polysaccharide Pneumococcal Vaccines in Chronic Smoker, Pathogenesis of Respiratory Viruses at Keystone Resort, Colorado, USA, 19-24 January 2014. |
| Lam C.W., Law C.Y., To K.K.W., Cheung K.K., Lee K.C., Sze K.H. and Yuen K.Y., Springer Poster Prize For Outstanding Poster Presentation Of Research In The Field Of Metabolomics In The Metabolomics Society 2013 Conference , Metabolomics Society 2013 Conference . 2013. |
| Lam Y.F., Wong D.K.H., Seto W.K.W., To K.K.W., Hung I.F.N., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., HLA-DP and interferon gamma receptor-2 gene variants and their association with viral hepatitis activity in chronic hepatitis B infection., Journal of Gastroenterology and Hepatology. 2014, 29(3): 533-539. |
| Liu R., To K.K.W., Teng L.L., Choi K.Y., Mok K.Y., Law K.I., Tso E.Y., Fung K.S., Wu T.C., Wu A.K.L., Fung S.H., Wong S.C.Y., Trendell-Smith N.J. and Yuen K.Y., Mycobacterium abscessus bacteremia after receipt of intravenous infusate of cytokine-induced killer cell therapy for body beautification and health boosting., Clinical infectious diseases. 2013, 57(7): 981-991. |
| Muthuri S.G., Venkatesan S., Myles P.R., Leonardi-Bee J., AI Khuwaitir T.S., AI Mamun A., Anovadiya A.P., Azziz-Baumgartner E., Báez C., Bassetti M., Beovic B., Bertisch B., Bonmarin I., Booy R., Borja-Aburto V.H., Burgmann H., Cao B., Carratala J., Denholm J.T., Dominguez S.R., Duarte P.A., Dubnov-Raz G., Echavarria M., Fanella S., Gao Z., Gérardin P., Giannella M., Gubbels S., Herberg J., Iglesias A.L., Hoger P.H., Hu X., Islam Q.T., Jiménez M.F., Kandeel A., Keijzers G., Khalili H., Knight M., Kudo K., Kusznierz G., Kuzman I., Kwan A.M., Amine I.L., Langenegger E., Lankarani K.B., Leo Y.S., Linko R., Liu P., Madanat F., Mayo-Montero E., McGeer A., Memish Z., Metan G., Mickiene A., Mikić D., Mohn K.G., Moradi A., Nymadawa P., Oliva M.E., Ozkan M., Parekh D., Paul M., Polack F.P., Rath B.A., Rodríguez A.H., Sarrouf E.B., Seale A.C., Sertogullarindan B., Siqueira M.M., Skręt-Magierło J., Stephan F., Talarek E., Tang J.W., To K.K.W., Torres A., Törün S.H., Tran D., Uyeki T.M., Van Zwol A., Vaudry W., Vidmar T., Yokota R.T., Zarogoulidis P., PRIDE Consortium Investigators .. and Nguyen-Van-Tam J.S., Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data., The Lancet. Respiratory medicine. 2014, 2(5): 395-404. |
| To K.K.W., Associate Editor, BMC Infectious Diseases. 2013. |
| To K.K.W., Lam C.W., Lee K.C., Yung K.Y., Law C.Y., Leung K.F., Lau K.C. and Chan S.F., Difference In The Metabolome Between Escherichia Coli Isolated From Patients With Pyelonephritis And Cholangitis, Metabolomics Society 2013 Conference . 2013. |
| To K.K.W., TSANG K.L., Chan J.F.W., Cheng V.C.C., Chen H. and Yuen K.Y., Emergence in China of human disease due to avian influenza A(H10N8) - Cause for concern?, Journal of Infection. 2014, 68(3): 205-215. |
| To K.K.W., Human infections due to avian influenza , The Global Emergency Medicine Meeting, 2014. 2014. |
| To K.K.W., Zhou J., Song Y., Hung I.F.N., Ip W.C.T., Cheng Z., Chan S.F., Kao R.Y.T., Wu A.K.L., Chau S.S., Luk W.K., Ip M.S.M., Chan K.H. and Yuen K.Y., Surfactant protein B gene polymorphism is associated with severe influenza., Chest. 2014, 145(6): 1237-1243. |
| To K.K.W., Chan J.F.W., Chen H., Li L.J. and Yuen K.Y., The emergence of influenza A H7N9 in human beings 16 years after influenza A H5N1: a tale of two cities, Lancet Infectious Diseases. 2013, 13(9): 809-821. |
| To K.K.W., Lam C.W., Wong S.S.Y., Law C.Y., Lee K.C., Yung K.Y., Cheung K.K. and Chan S.F., Urine Metabolomics Profile Of Patients With Or Without Bacteremia, International Symposium on Translating Omics Science to Clinical Applications 2013 (TOSCA'13). 2013. |
| To K.K.W., Chan J.F.W. and Yuen K.Y., Viral lung infections: epidemiology, virology, clinical features, and management of avian influenza A(H7N9)., Current opinion in pulmonary medicine. 2014, 20(3): 225-232. |
| Yang S.G., Chen Y., Cui D.W., Yao H.P., Lou J.Z., Huo Z.X., Xie G.L., Yu F., Zheng S.F., Yang Y.D., Zhu Y.X., Lu X.Q., Liu X.L., Lau S.Y., Chan J.F.W., To K.K.W., Yuen K.Y., Chen H. and Li L.J., Avian-Origin Influenza A(H7N9) Infection in Influenza A(H7N9)-Affected Areas of China: A Serological Study, Journal of Infectious Diseases. 2014, 209(2): 265-269. |
| Yu L., Wang Z.M., Chen Y., Ding W., Jia H.Y., Chan J.F.W., To K.K.W., Chen H., Yang Y.D., Liang W.F., Zheng S.F., Yao H.P., Yang S.G., Cao H.C., Dai X.H., Zhao H., Li J., Bao Q.L., Chen P., Hou X.L., Li L.J. and Yuen K.Y., Clinical, Virological, and Histopathological Manifestations of Fatal Human Infections by Avian Influenza A(H7N9) Virus, Clinical Infectious Diseases. 2013, 57(10): 1449-1457. |
| Zhang J., Li C., To K.K.W., Zhu H., Lee C.Y., Li C., Chan J.F.W., Hung I.F.N. and Yuen K.Y., Toll-like receptor 7 agonist imiquimod in combination with influenza vaccine expedites and augments humoral immune responses against influenza A(H1N1)pdm09 virus infection in BALB/c mice., Clinical and vaccine immunology. 2014, 21(4): 570-579. |
| Zhou J., Chu H., Li C., Wong H.Y.B., Cheng Z., Poon K.M., Sun T., Lau C.Y., Wong K.K., Chan J.Y.K., Chan J.F.W., To K.K.W., Chan K.H., Zheng B. and Yuen K.Y., Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis., J Infect Dis. 2014, 209(9): 1331-42. |
| Researcher : To WCS |
| List of Research Outputs |
| To W.C.S., Chen J.H.K., Wong K.H., Chan K.C.W., Ng H.M., Wu H., Lam T.H. and Yam W.C., Performance comparison of an in-house integrase genotyping assay versus the ViroSeq (TM) Integra48, and study of HIV-1 integrase polymorphisms in Hong Kong, In: To SW, Chen JH, Wong KH, Chan KC, Ng HM, Wu H, Lam JT, Yam WC, J Clin Virol. 2013, 58(1): 299-302. |
| To W.C.S., Chen J.H.K., Wong K.H., Chan K.C.W., Ng H.M., Wu H., Lam J.T. and Yam W.C., Performance comparison of an in-house integrase genotyping assay versus the ViroSeq™ Integra48, and study of HIV-1 integrase polymorphisms in Hong Kong, Journal of Clinical Virology. 2013, 58: 299-302. |
| Researcher : Tsang KL |
| List of Research Outputs |
| Lau S.K.P., Li K.S.M., Tsang K.L., Lam S.F., Ahmed S.S., Chen H., Chan K.H., Woo P.C.Y. and Yuen K.Y., Genetic Characterization of Betacoronavirus Lineage C Viruses in Bats Reveals Marked Sequence Divergence in the Spike Protein of Pipistrellus Bat Coronavirus HKU5 in Japanese Pipistrelle: Implications for the Origin of the Novel Middle East Respiratory Syndrome Coronavirus, Journal of Virology. 2013, 87: 8638-8650. |
| To K.K.W., TSANG K.L., Chan J.F.W., Cheng V.C.C., Chen H. and Yuen K.Y., Emergence in China of human disease due to avian influenza A(H10N8) - Cause for concern?, Journal of Infection. 2014, 68(3): 205-215. |
| Woo P.C.Y., Lau S.K.P., Lam S.F., Tsang K.L., Hui S.W., Fan Y.Y., Martelli P. and Yuen K.Y., Discovery of a novel bottlenose dolphin coronavirus reveals a distinct species of marine mammal coronavirus in Gammacoronavirus, Journal of Virology . 2014, 88: 1318-1331. |
| Woo P.C.Y., Lau S.K.P., Teng L.L., Tsang K.L., Joseph M., Wong Y.M., TANG Y., Sivakumar S., Xie J., BAI R., Wernery R., Wernery U. and Yuen K.Y., New hepatitis E virus genotype in camel, the Middle East, Emerging Infectious Diseases . 2014, 20: 1044-1048. |
| Woo P.C.Y., Lau S.K.P., Wernery U., Wong Y.M., Tsang K.L., Johnson B., Yip C.Y., Lau C.Y., Sivakumar S., Cai J., Fan Y.Y., Chan K.H., Mareena R. and Yuen K.Y., Novel betacoronavirus in dromedaries of the Middle East, 2013, Emerging Infectious Diseases. 2014, 20: 560-572. |
| Researcher : Tse H |
| Project Title: | Phylogenetic reconstruction of coronavirus evolution under non-homogeneous, non-stationary models |
| Investigator(s): | Tse H, Lau SKP, Yuen KY, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 04/2012 |
| Completion Date: | 03/2014 |
| Project Title: | Molecular characterization of antibiotic resistance in Staphylococcus lugdunensis isolates |
| Investigator(s): | Tse H, Ho PL |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2014 |
| Project Title: | Molecular characterization of tetracycline resistance in Elizabethkingia anophelis |
| Investigator(s): | Tse H, Lau SKP, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2014 |
| List of Research Outputs |
| Lau S.K.P., Woo P.C.Y., Yip C.Y., BAI R., WU Y., Tse H. and Yuen K.Y., Complete genome sequence of a novel feline astrovirus from domestic cat in Hong Kong, Genome Announcements . 2013, 1: e00708-13. |
| Lau S.K.P., Tse H., CHAN S.Y.J., Zhou A.C., Curreem S.O.T., Lau C.Y., Yuen K.Y. and Woo P.C.Y., Proteome profiling of the dimorphic fungus Penicillium marneffei extracellular proteins and identification of glyceraldehyde-3-phosphate dehydrogenase as an important adhesion factor for conidial attachment, FEBS Journal . 2013, 280: 6613-6626. |
| Siu K.L., Yeung M.C., Kok K.H., Yuen K.S., Kew C., Lui P.Y., Chan C.P., Tse H., Woo P.C.Y., Yuen K.Y. and Jin D., Middle East respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in innate antiviral response, Journal of Virology . 2014, 88: 4866-4876. |
| Yang E., Wang G., Woo P.C.Y., Lau S.K.P., Chow W.N., Chong T.K., Tse H., Kao R.Y.T., Chan C.M., Che X., Yuen K.Y. and Cai J.J., Unraveling the molecular basis of temperature-dependent genetic regulation in Penicillium marneffei, Eukaryotic Cell . 2013, 12: 1214-1224. |
| Researcher : Tse MK |
| List of Research Outputs |
| Tse M.K., Cheung K.K., Ke Y., Lau C.Y., Sze K.H. and Yuen K.Y., Backbone and side-chain ¹H, ¹³C and ¹⁵N assignments of the PPIase domain of macrophage infectivity potentiator (Mip) protein from Coxiella burnetii., Biomolecular NMR assignments. 2014, 8(1): 173-176. |
| Researcher : Tsoi HW |
| List of Research Outputs |
| Lau S.K.P., Woo P.C.Y., WU Y., WONG Y.P., Wong B.H.L., Lau C.Y., Fan Y.Y., Cai J., Tsoi H.W., Chan K.H. and Yuen K.Y., Identification and characterization of a novel paramyxovirus, porcine parainfluenza 1 virus, from deceased pigs, Journal of General Virology. 2013, 94: 2184-2190. |
| Researcher : WEN X |
| List of Research Outputs |
| WEN X., HUANG X., Mok B.W.Y., Chen Y.X., ZHENG M., Lau S.Y., Wang P., Song W., Jin D., Yuen K.Y. and Chen H., NF90 Exerts Antiviral Activity through Regulation of PKR Phosphorylation and Stress Granules in Infected Cells, Journal of Immunology. 2014, 192(8): 3753-3764. |
| Researcher : WONG YP |
| List of Research Outputs |
| Lau S.K.P., Woo P.C.Y., WU Y., WONG Y.P., Wong B.H.L., Lau C.Y., Fan Y.Y., Cai J., Tsoi H.W., Chan K.H. and Yuen K.Y., Identification and characterization of a novel paramyxovirus, porcine parainfluenza 1 virus, from deceased pigs, Journal of General Virology. 2013, 94: 2184-2190. |
| Lau S.K.P., Chow W.N., Wong Y.P., Yeung M.Y., Bao Y., Zhang N., Lok S., Woo P.C.Y. and Yuen K.Y., Identification of MicroRNA-like RNAs in Mycelial and yeast phases of the thermal dimorphic fungus Penicillium marneffei, PLoS Neglected Tropical Diseases. 2013, 7: e2398. |
| Teng L.L., HO C.C., Yeung R.S.Y., Wong Y.P., Wang H., Chen C., Fung K.S.C., Lau S.K.P. and Woo P.C.Y., Evaluation of 16SpathDB 2.0, an automated 16S rRNA gene sequence database, using 689 complete bacterial genomes, Diagnostic Microbiology and Infectious Disease. 2014, 78: 105-115. |
| Researcher : WU Y |
| List of Research Outputs |
| Lau S.K.P., Woo P.C.Y., Yip C.Y., BAI R., WU Y., Tse H. and Yuen K.Y., Complete genome sequence of a novel feline astrovirus from domestic cat in Hong Kong, Genome Announcements . 2013, 1: e00708-13. |
| Lau S.K.P., Woo P.C.Y., WU Y., WONG Y.P., Wong B.H.L., Lau C.Y., Fan Y.Y., Cai J., Tsoi H.W., Chan K.H. and Yuen K.Y., Identification and characterization of a novel paramyxovirus, porcine parainfluenza 1 virus, from deceased pigs, Journal of General Virology. 2013, 94: 2184-2190. |
| Researcher : Wang H |
| Project Title: | Induction of gp41-specific IgA to prevent HIV infection. |
| Investigator(s): | Wang H, Chen Z |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2012 |
| Completion Date: | 10/2013 |
| List of Research Outputs |
| Peng Q., Wang H., Wang H., Li X., LU X., Liu L., Zhou B. and Chen Z., Imbalances of Gut-Homing CD4+ T-Cell Subsets in HIV-1–Infected Chinese Patients, JAIDS Journal of Acquired Immune Deficiency Syndromes. 2013, 64: 25-31. |
| Peng Q., Chen Z., Wang H., Li X., LU X., Liu L., Zhou B. and Wang H., Imbalances of gut-homing CD4+ T cell subsets in HIV-1 infected Chinese patients., Journal of Acquired Immune Deficiency Syndromes. 2013, 64(1): 25-31. |
| Researcher : Wang P |
| List of Research Outputs |
| Song W., Wang P., Chen Y., Yang S., Wu N., Lau S.Y., Wu W.L., Mok B.W.Y., Cui D., Huo Z., Zheng M., Huang X., Li L., Yuen K.Y. and Chen H., Mammalian adaptation markers in avian-origin H7N9 virus, a comprehensive investigation in isolates and clinical specimens from the H7N9 influenza affected area, VIII Options for the control of influenza, Cape Town, South Africa, September 2013. |
| WEN X., HUANG X., Mok B.W.Y., Chen Y.X., ZHENG M., Lau S.Y., Wang P., Song W., Jin D., Yuen K.Y. and Chen H., NF90 Exerts Antiviral Activity through Regulation of PKR Phosphorylation and Stress Granules in Infected Cells, Journal of Immunology. 2014, 192(8): 3753-3764. |
| Wu H.Z., Song W., Gao X., Liu N., Wang P., Chen H. and Cai Z.W., Proteomics study of N-acetylcysteine response in H1N1-infected cells by using mass spectrometry, Rapid Communications in Mass Spectrometry. 2014, 28(7): 741-749. |
| Researcher : Wong BHL |
| List of Research Outputs |
| Lau S.K.P., Woo P.C.Y., WU Y., WONG Y.P., Wong B.H.L., Lau C.Y., Fan Y.Y., Cai J., Tsoi H.W., Chan K.H. and Yuen K.Y., Identification and characterization of a novel paramyxovirus, porcine parainfluenza 1 virus, from deceased pigs, Journal of General Virology. 2013, 94: 2184-2190. |
| Researcher : Wong HYB |
| List of Research Outputs |
| Chu H., Zhou J., Wong H.Y.B., Li C., Cheng Z., Lin X., Poon K.M., Sun T., Lau C.Y., Chan J.F.W., To K.K.W., Chan K.H., Lu L., Zheng B. and Yuen K.Y., Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response. , Virology. 2014, 454-455: 197-205. |
| Zhou J., Chu H., Li C., Wong H.Y.B., Cheng Z., Poon K.M., Sun T., Lau C.Y., Wong K.K., Chan J.Y.K., Chan J.F.W., To K.K.W., Chan K.H., Zheng B. and Yuen K.Y., Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis., J Infect Dis. 2014, 209(9): 1331-42. |
| Researcher : Wong KH |
| List of Research Outputs |
| To W.C.S., Chen J.H.K., Wong K.H., Chan K.C.W., Ng H.M., Wu H., Lam T.H. and Yam W.C., Performance comparison of an in-house integrase genotyping assay versus the ViroSeq (TM) Integra48, and study of HIV-1 integrase polymorphisms in Hong Kong, In: To SW, Chen JH, Wong KH, Chan KC, Ng HM, Wu H, Lam JT, Yam WC, J Clin Virol. 2013, 58(1): 299-302. |
| Researcher : Wong SCY |
| List of Research Outputs |
| Chan J.F.W., Teng L.L., Li W.S., Wong S.C.Y., Leung S.S.M., Ho P.O., To K.K.W., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Fatal empyema thoracis caused by Schizophyllum commune with cross-reactive cryptococcal antigenemia, Journal of Clinical Microbiology . 2014, 52: 683-687. |
| Chan J.F.W., Lau S.K.P., Wong S.C.Y., To K.K.W., Cheng V.C.C., Yuen K.Y. and Woo P.C.Y., Ten-year retrospective case series of patients with galactomannan antigenemia: implications on the use of serum galactomannan antigen in the diagnosis of invasive and non-invasive aspergillosis, ECCMID 2014, European Society of Clinical Microbiology and Infectious Diseases. 2014. |
| Cheng V.C.C., Wong S.C.Y., Sridhar S., Chan J.F.W., Ng M.L.M., Lau S.K.P., Woo P.C.Y., Lo E.C.M., Chan K.K.C. and Yuen K.Y., Management of an incident of failed sterilization of surgical instruments in a dental clinic in Hong Kong, Journal of the Formosan Medical Association. 2013, 112: 666-675. |
| Cheng V.C.C., Tai J.W.M., Chau P.H., Chen J.H.K., Yan M.K., So S.Y.C., To K.K.W., Chan J.F.W., Wong S.C.Y., Ho P.L. and Yuen K.Y., Minimal intervention for controlling nosocomial transmission of Methicillin-Resistant Staphylococcus aureus in resource limited setting with high endemicity, PLoS One. 2014, 9: e100493. |
| Cheng V.C.C., Tai J.W.M., Chen J.H.K., So S.Y., Ng W.C., Hung I.F.N., Leung S.S., Wong S.C.Y., Chan T.C., Chan F.H., Ho P.L. and Yuen K.Y., Proactive infection control measures to prevent nosocomial transmission of vancomycin-resistant enterococci in Hong Kong.ournal of the Formosan Medical Association, Journal of the Formosan Medical Association. 2014. |
| Ho P.L., Chau P.H., Yan M.K., Chow K.H., Chen J.H.K., Wong S.C.Y. and Cheng V.C.C., High burden of extended-spectrum β-lactamase-positive Escherichia coli in geriatric patients, Journal of Medical Microbiology. 2014, 63: 878-883. |
| Liu R., To K.K.W., Teng L.L., Choi K.Y., Mok K.Y., Law K.I., Tso E.Y., Fung K.S., Wu T.C., Wu A.K.L., Fung S.H., Wong S.C.Y., Trendell-Smith N.J. and Yuen K.Y., Mycobacterium abscessus bacteremia after receipt of intravenous infusate of cytokine-induced killer cell therapy for body beautification and health boosting., Clinical infectious diseases. 2013, 57(7): 981-991. |
| Wong S.S.Y., Fung K.S., Chau S., Poon W.S.R., Wong S.C.Y. and Yuen K.Y., Molecular diagnosis in clinical parasitology: When and why?, Experimental biology and medicine. 2014. |
| Researcher : Wong SSY |
| Project Title: | Molecular characterization of streptococcus bovis bacteraemia |
| Investigator(s): | Wong SSY, Yuen KY, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Project Title: | Characterization of bacterial isolates with ambiguous biochemical profiles recovered from patients with clinically significant bacteremia by 16S rRNA gene sequencing, the state-of-the-art molecular technique for bacterial identification |
| Investigator(s): | Wong SSY, Woo PCY, Lau SKP |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| List of Research Outputs |
| To K.K.W., Lam C.W., Wong S.S.Y., Law C.Y., Lee K.C., Yung K.Y., Cheung K.K. and Chan S.F., Urine Metabolomics Profile Of Patients With Or Without Bacteremia, International Symposium on Translating Omics Science to Clinical Applications 2013 (TOSCA'13). 2013. |
| Wong S.S.Y., Fung K.S., Chau S., Poon W.S.R., Wong S.C.Y. and Yuen K.Y., Molecular diagnosis in clinical parasitology: When and why?, Experimental biology and medicine. 2014. |
| Yip C.Y., Lau S.K.P., Woo P.C.Y., Wong S.S.Y., Tsang T.H.F., Lo J.Y.C., Lam W.K., Tsang C.C., Chan K.H. and Yuen K.Y., Recombinant Coxsackievirus A2 and Deaths of Children, Hong Kong, 2012, Emerging Infectious Diseases. 2013, 19: 1285-1288. |
| Researcher : Wong YM |
| List of Research Outputs |
| Woo P.C.Y., Lau S.K.P., Teng L.L., Tsang K.L., Joseph M., Wong Y.M., TANG Y., Sivakumar S., Xie J., BAI R., Wernery R., Wernery U. and Yuen K.Y., New hepatitis E virus genotype in camel, the Middle East, Emerging Infectious Diseases . 2014, 20: 1044-1048. |
| Woo P.C.Y., Lau S.K.P., Wernery U., Wong Y.M., Tsang K.L., Johnson B., Yip C.Y., Lau C.Y., Sivakumar S., Cai J., Fan Y.Y., Chan K.H., Mareena R. and Yuen K.Y., Novel betacoronavirus in dromedaries of the Middle East, 2013, Emerging Infectious Diseases. 2014, 20: 560-572. |
| Researcher : Wong YP |
| List of Research Outputs |
| Lau S.K.P., Woo P.C.Y., WU Y., WONG Y.P., Wong B.H.L., Lau C.Y., Fan Y.Y., Cai J., Tsoi H.W., Chan K.H. and Yuen K.Y., Identification and characterization of a novel paramyxovirus, porcine parainfluenza 1 virus, from deceased pigs, Journal of General Virology. 2013, 94: 2184-2190. |
| Lau S.K.P., Chow W.N., Wong Y.P., Yeung M.Y., Bao Y., Zhang N., Lok S., Woo P.C.Y. and Yuen K.Y., Identification of MicroRNA-like RNAs in Mycelial and yeast phases of the thermal dimorphic fungus Penicillium marneffei, PLoS Neglected Tropical Diseases. 2013, 7: e2398. |
| Teng L.L., HO C.C., Yeung R.S.Y., Wong Y.P., Wang H., Chen C., Fung K.S.C., Lau S.K.P. and Woo P.C.Y., Evaluation of 16SpathDB 2.0, an automated 16S rRNA gene sequence database, using 689 complete bacterial genomes, Diagnostic Microbiology and Infectious Disease. 2014, 78: 105-115. |
| Researcher : Woo P.C.Y. |
| Project Title: | Molecular evolution and interspecies jumping in picornaviruses |
| Investigator(s): | Woo PCY, Lau SKP, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2011 |
| Completion Date: | 09/2013 |
| Project Title: | Significance of Lichtheimia hongkongensis as a cause of mucormycosis |
| Investigator(s): | Woo PCY, Lau SKP, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2012 |
| Completion Date: | 12/2013 |
| Project Title: | Molecular epidemiology of Exophiala infections in Hong Kong |
| Investigator(s): | Woo PCY, Lau SKP, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2013 |
| Project Title: | Infection and Immunology |
| Investigator(s): | Woo PCY, Yuen KY, Watt RM |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 06/2013 |
| Project Title: | Nuclear ribosomal internal transcribed spacer (ITS) region as a DNA barcode for the identification of pathogenic fungi that are difficult to identify in clinical laboratories |
| Investigator(s): | Woo PCY, Lau SKP, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2014 |
| List of Research Outputs |
| Researcher : Woo PCY |
| Project Title: | Molecular evolution and interspecies jumping in picornaviruses |
| Investigator(s): | Woo PCY, Lau SKP, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2011 |
| Completion Date: | 09/2013 |
| Project Title: | Significance of Lichtheimia hongkongensis as a cause of mucormycosis |
| Investigator(s): | Woo PCY, Lau SKP, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2012 |
| Completion Date: | 12/2013 |
| Project Title: | Molecular epidemiology of Exophiala infections in Hong Kong |
| Investigator(s): | Woo PCY, Lau SKP, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2013 |
| Project Title: | Infection and Immunology |
| Investigator(s): | Woo PCY, Yuen KY, Watt RM |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 06/2013 |
| Project Title: | Nuclear ribosomal internal transcribed spacer (ITS) region as a DNA barcode for the identification of pathogenic fungi that are difficult to identify in clinical laboratories |
| Investigator(s): | Woo PCY, Lau SKP, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2014 |
| List of Research Outputs |
| Basler C.F. and Woo P.C.Y., Editorial overview: emerging viruses, Current Opinion in Virology . 2014, 5: v-vii. |
| Chan J.F.W., Teng L.L., Li W.S., Wong S.C.Y., Leung S.S.M., Ho P.O., To K.K.W., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Fatal empyema thoracis caused by Schizophyllum commune with cross-reactive cryptococcal antigenemia, Journal of Clinical Microbiology . 2014, 52: 683-687. |
| Chan J.F.W., Lau S.K.P., Wong S.C.Y., To K.K.W., Cheng V.C.C., Yuen K.Y. and Woo P.C.Y., Ten-year retrospective case series of patients with galactomannan antigenemia: implications on the use of serum galactomannan antigen in the diagnosis of invasive and non-invasive aspergillosis, ECCMID 2014, European Society of Clinical Microbiology and Infectious Diseases. 2014. |
| Chan J.F.W., Lau S.K.P. and Woo P.C.Y., The emerging novel Middle East Respiratory Syndrome Coronavirus: the “knowns” and “unknowns”. , Journal of Formosan Medical Association. 2013, 112: 372-381. |
| Chan T.C.I., Hung I.F.N., Luk J.K.H., Woo P.C.Y., Chu L.W. and Chan F.H.W., Efficacy of trivalent seasonal influenza vaccination in reducing mortality and hospitalization in Chinese nursing home older adults, Journal of the American Medical Directors Association . 2013, 14: 889-894. |
| Chan T.C.I., Hung I.F.N., Cheng V.C.C., Luk J.K.H., Woo P.C.Y., Chu L.W. and Chan F.H.W., Is Nursing Home Residence an Independent Risk Factor of Mortality in Chinese Older Adults?, Journal of the American Geriatrics Society . 2013, 61(8): 1430-1432. |
| Chan T.C.I., Hung I.F.N., Luk J.K.H., Woo P.C.Y., Chu L.W. and Chan F.H.W., Prevalence of Influenza Vaccination and Associated Factors in Chinese Nursing Home Healthcare Workers, Journal of the American Geriatrics Society . 2013, 61(10): 1824-1827. |
| Cheng V.C.C., Wong S.C.Y., Sridhar S., Chan J.F.W., Ng M.L.M., Lau S.K.P., Woo P.C.Y., Lo E.C.M., Chan K.K.C. and Yuen K.Y., Management of an incident of failed sterilization of surgical instruments in a dental clinic in Hong Kong, Journal of the Formosan Medical Association. 2013, 112: 666-675. |
| HO C.C., Lau S.K.P. and Woo P.C.Y., Romance of the Three Domains: how cladistics transformed the classification of cellular organisms, Protein & Cell . 2013, 4: 664-676. |
| Lau S.K.P., Woo P.C.Y., Yip C.Y., BAI R., WU Y., Tse H. and Yuen K.Y., Complete genome sequence of a novel feline astrovirus from domestic cat in Hong Kong, Genome Announcements . 2013, 1: e00708-13. |
| Lau S.K.P., Lau C.Y., Chan K.H., Li P.Y., Chen H., Jin D., Chan J.F.W., Woo P.C.Y. and Yuen K.Y., Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment, Journal of General Virology. 2013, 94: 2679-2690. |
| Lau S.K.P., Li K.S.M., Tsang K.L., Lam S.F., Ahmed S.S., Chen H., Chan K.H., Woo P.C.Y. and Yuen K.Y., Genetic Characterization of Betacoronavirus Lineage C Viruses in Bats Reveals Marked Sequence Divergence in the Spike Protein of Pipistrellus Bat Coronavirus HKU5 in Japanese Pipistrelle: Implications for the Origin of the Novel Middle East Respiratory Syndrome Coronavirus, Journal of Virology. 2013, 87: 8638-8650. |
| Lau S.K.P., Woo P.C.Y., WU Y., WONG Y.P., Wong B.H.L., Lau C.Y., Fan Y.Y., Cai J., Tsoi H.W., Chan K.H. and Yuen K.Y., Identification and characterization of a novel paramyxovirus, porcine parainfluenza 1 virus, from deceased pigs, Journal of General Virology. 2013, 94: 2184-2190. |
| Lau S.K.P., Chow W.N., Wong Y.P., Yeung M.Y., Bao Y., Zhang N., Lok S., Woo P.C.Y. and Yuen K.Y., Identification of MicroRNA-like RNAs in Mycelial and yeast phases of the thermal dimorphic fungus Penicillium marneffei, PLoS Neglected Tropical Diseases. 2013, 7: e2398. |
| Lau S.K.P., Tang B.S.F., Teng L.L., Chan T.M., Curreem S.O.T., Fan Y.Y., Ng R.H.Y., Chan J.F.W., Yuen K.Y. and Woo P.C.Y., Matrix-assisted laser desorption ionisation time-of-flight mass spectrometry for identification of clinically significant bacteria that are difficult to identify in clinical laboratories, Journal of Clinical Pathology . 2014, 67: 361-366. |
| Lau S.K.P., Tse H., CHAN S.Y.J., Zhou A.C., Curreem S.O.T., Lau C.Y., Yuen K.Y. and Woo P.C.Y., Proteome profiling of the dimorphic fungus Penicillium marneffei extracellular proteins and identification of glyceraldehyde-3-phosphate dehydrogenase as an important adhesion factor for conidial attachment, FEBS Journal . 2013, 280: 6613-6626. |
| Lau S.K.P., Curreem S.O.T., Lin C.C.N., Fung A.M.Y., Yuen K.Y. and Woo P.C.Y., Streptococcus hongkongensis sp. nov., isolated from a patient with an infected puncture wound and from a marine flatfish., International Journal of Systematic and Evolutionary Microbiology. 2013, 63: 2570-2576. |
| Lee P.P.W., Mao H., Yang W., Chan K.W., Ho M.H.K., Lee T.L., Chan J.F.W., Woo P.C.Y., Tu W. and Lau Y.L., Penicillium marneffei infection and impaired IFN-γ immunity in humans with autosomal-dominant gain-of-phosphorylation STAT1 mutations, Journal of Allergy and Clinical Immunology. 2013. |
| Leung S.Y., Huang Y., Lau S.K.P. and Woo P.C.Y., Complete mitochondrial genome sequence of Lichtheimia ramosa (syn. Lichtheimia hongkongensis), Genome Announcements . 2014, 2: e00644-14. |
| Li B., Hu Y., Wang Q., Yi Y., Woo P.C.Y., Jing H., Zhu B. and Liu C.H., Structural Diversity of Class 1 integrons and their associated gene cassettes in Klebsiella pneumoniae isolates from a hospital in China, PLoS One . 2013, 8: e75805. |
| Siu K.L., Chan C.P., Kok K.H., Woo P.C.Y. and Jin D., Comparative analysis of the activation of unfolded protein response by spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus HKU1, Cell & Bioscience . 2014, 4: 3. |
| Siu K.L., Yeung M.C., Kok K.H., Yuen K.S., Kew C., Lui P.Y., Chan C.P., Tse H., Woo P.C.Y., Yuen K.Y. and Jin D., Middle East respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in innate antiviral response, Journal of Virology . 2014, 88: 4866-4876. |
| Siu K.L., Chan C.P., Kok K.H., Woo P.C.Y. and Jin D., Suppression of innate antiviral response by severe acute respiratory syndrome coronavirus M protein is mediated through the first transmembrane domain, Cellular & Molecular Immunology. 2014, 11: 141-149. |
| Tam W.T., Chen J.H.K., Lau E.C.L., Ngan A.H.Y., Fung K.S.C., Lee K.C., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Misidentification of Aspergillus nomius and Aspergillus tamarii as Aspergillus flavus: Characterization by Internal Transcribed Spacer, -Tubulin, and Calmodulin Gene Sequencing, Metabolic Fingerprinting, and Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry, In: Tam EW, Chen JH, Lau EC, Ngan AH, Fung KS, Lee KC, Lam CW, Yuen KY, Lau SK, Woo PC, Journal of Clinical Microbiology. 2014, 52: 1153-1160. |
| Tam W.T., Chen J.H.K., Lau E.C., Ngan A.H., Fung K.S., Lee K.C., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Misidentification of Aspergillus nomius and Aspergillus tamarii as Aspergillus flavus: characterization by internal transcribed spacer, β-Tubulin, and calmodulin gene sequencing, metabolic fingerprinting, and matrix-assisted laser desorption ionization-time of flight mass spectrometry, In: Tam EW, Chen JH, Lau EC, Ngan AH, Fung KS, Lee KC, Lam CW, Yuen KY, Lau SK, Woo PC, J Clin Microbiol. 2014. |
| Tang B.S.F., Lau S.K.P., Teng L.L., Chan T.M., Chan W.S., Wong T.Y., Tong Y.T., Fan Y.Y., Yuen K.Y. and Woo P.C.Y., Matrix-assisted laser desorption ionisation-time of flight mass spectrometry for rapid identification of Laribacter hongkongensis, Journal of Clinical Pathology . 2013, 66: 1081-1083. |
| Teng L.L., HO C.C., Yeung R.S.Y., Wong Y.P., Wang H., Chen C., Fung K.S.C., Lau S.K.P. and Woo P.C.Y., Evaluation of 16SpathDB 2.0, an automated 16S rRNA gene sequence database, using 689 complete bacterial genomes, Diagnostic Microbiology and Infectious Disease. 2014, 78: 105-115. |
| Tse C.W.S., Curreem S.O.T., Cheung I., Tang B.S.F., Leung K.W., Lau S.K.P. and Woo P.C.Y., Novel MLST sequence type clustered with other sequence types of human isolates discovered in first fatal case of Laribacter hongkongensis bacteremia, Emerging Microbes and Infections . 2014, 3: e41. |
| Wang H., Du P., Li J., Zhang Y., Zhang W., Han N., Woo P.C.Y. and Chen C., Comparative analysis of microbiome between accurately identified 16S rDNA and quantified bacteria in simulated samples, Journal of Medical Microbiology . 2014, 63: 433-440. |
| Woo P.C.Y., Coronavirus diversity, phylogeny and interspecies jumping, Annual Scientific Meeting for Taiwan Society of Microbiology (Taipei, Taiwan) . 2013. |
| Woo P.C.Y., Coronavirus diversity, phylogeny and interspecies jumping, Emerging Infectious Disease workshop (Guangzhou, China). 2013. |
| Woo P.C.Y., Coronavirus diversity, phylogeny and interspecies jumping, University of Electronic Science and Technology of China (Chengdu, China). 2014. |
| Woo P.C.Y., Lau S.K.P., Lam S.F., Tsang K.L., Hui S.W., Fan Y.Y., Martelli P. and Yuen K.Y., Discovery of a novel bottlenose dolphin coronavirus reveals a distinct species of marine mammal coronavirus in Gammacoronavirus, Journal of Virology . 2014, 88: 1318-1331. |
| Woo P.C.Y., Guest editor (Emerging bacterial and fungal infections), Emerging Microbes and Infections, 2014. |
| Woo P.C.Y., Lau S.K.P., Teng L.L., Tsang K.L., Joseph M., Wong Y.M., TANG Y., Sivakumar S., Xie J., BAI R., Wernery R., Wernery U. and Yuen K.Y., New hepatitis E virus genotype in camel, the Middle East, Emerging Infectious Diseases . 2014, 20: 1044-1048. |
| Woo P.C.Y., Lau S.K.P., Wernery U., Wong Y.M., Tsang K.L., Johnson B., Yip C.Y., Lau C.Y., Sivakumar S., Cai J., Fan Y.Y., Chan K.H., Mareena R. and Yuen K.Y., Novel betacoronavirus in dromedaries of the Middle East, 2013, Emerging Infectious Diseases. 2014, 20: 560-572. |
| Woo P.C.Y., Novel viruses discovered in dromedary camels, Central Veterinary Research Laboratory (Dubai, UAE). 2014. |
| Woo P.C.Y., Ten years experience on coronavirus discovery, Workshop for giant panda disease prevention and control (Dujiangyan, China). 2013. |
| Xiong L., Teng L.L., Watt R.M., Kan B.I.A.O., Lau S.K.P. and Woo P.C.Y., Arginine deiminase pathway is far more important than urease for acid resistance and intracellular survival in Laribacter hongkongensis: a possible result of arc gene cassette duplication., BMC microbiology. 2014, 14http://www.biomedcentral.com/1471-2180/14/42. |
| Yang E., Wang G., Woo P.C.Y., Lau S.K.P., Chow W.N., Chong T.K., Tse H., Kao R.Y.T., Chan C.M., Che X., Yuen K.Y. and Cai J.J., Unraveling the molecular basis of temperature-dependent genetic regulation in Penicillium marneffei, Eukaryotic Cell . 2013, 12: 1214-1224. |
| Yip C.Y., Lau S.K.P., Lo J.Y.C., Chan K.H., Woo P.C.Y. and Yuen K.Y., Genetic characterization of EV71 isolates from 2004 to 2010 reveals predominance and persistent circulation of the newly proposed genotype D and recent emergence of a distinct lineage of subgenotype C2 in Hong Kong, Virology Journal. 2013, 10: 222. |
| Yip C.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Human enterovirus 71 epidemics: what's next?, Emerging Health Threats Journal. 2013, 6: 19780. |
| Yip C.Y., Lau S.K.P., Woo P.C.Y., Wong S.S.Y., Tsang T.H.F., Lo J.Y.C., Lam W.K., Tsang C.C., Chan K.H. and Yuen K.Y., Recombinant Coxsackievirus A2 and Deaths of Children, Hong Kong, 2012, Emerging Infectious Diseases. 2013, 19: 1285-1288. |
| de Groot R.J., Baker S.C., Baric R.S., Brown C.S., Drosten C., Enjuanes L., Fouchier R.A., Galiano M., Gorbalenya A.E., Memish Z.A., Perlman S., Poon L.L.M., Snijder E.J., Stephens G.M., Woo P.C.Y., Zaki A.M., Zambon M. and Ziebuhr J., Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group, Journal of virology. 2013, 87(14): 7790-2. |
| Researcher : Wu AKL |
| List of Research Outputs |
| Liu R., To K.K.W., Teng L.L., Choi K.Y., Mok K.Y., Law K.I., Tso E.Y., Fung K.S., Wu T.C., Wu A.K.L., Fung S.H., Wong S.C.Y., Trendell-Smith N.J. and Yuen K.Y., Mycobacterium abscessus bacteremia after receipt of intravenous infusate of cytokine-induced killer cell therapy for body beautification and health boosting., Clinical infectious diseases. 2013, 57(7): 981-991. |
| To K.K.W., Zhou J., Song Y., Hung I.F.N., Ip W.C.T., Cheng Z., Chan S.F., Kao R.Y.T., Wu A.K.L., Chau S.S., Luk W.K., Ip M.S.M., Chan K.H. and Yuen K.Y., Surfactant protein B gene polymorphism is associated with severe influenza., Chest. 2014, 145(6): 1237-1243. |
| Researcher : Wu H |
| List of Research Outputs |
| To W.C.S., Chen J.H.K., Wong K.H., Chan K.C.W., Ng H.M., Wu H., Lam T.H. and Yam W.C., Performance comparison of an in-house integrase genotyping assay versus the ViroSeq (TM) Integra48, and study of HIV-1 integrase polymorphisms in Hong Kong, In: To SW, Chen JH, Wong KH, Chan KC, Ng HM, Wu H, Lam JT, Yam WC, J Clin Virol. 2013, 58(1): 299-302. |
| Researcher : Wu WL |
| List of Research Outputs |
| Song W., Wang P., Chen Y., Yang S., Wu N., Lau S.Y., Wu W.L., Mok B.W.Y., Cui D., Huo Z., Zheng M., Huang X., Li L., Yuen K.Y. and Chen H., Mammalian adaptation markers in avian-origin H7N9 virus, a comprehensive investigation in isolates and clinical specimens from the H7N9 influenza affected area, VIII Options for the control of influenza, Cape Town, South Africa, September 2013. |
| Researcher : Xie J |
| List of Research Outputs |
| Woo P.C.Y., Lau S.K.P., Teng L.L., Tsang K.L., Joseph M., Wong Y.M., TANG Y., Sivakumar S., Xie J., BAI R., Wernery R., Wernery U. and Yuen K.Y., New hepatitis E virus genotype in camel, the Middle East, Emerging Infectious Diseases . 2014, 20: 1044-1048. |
| Researcher : Xiong L |
| List of Research Outputs |
| Xiong L., Teng L.L., Watt R.M., Kan B.I.A.O., Lau S.K.P. and Woo P.C.Y., Arginine deiminase pathway is far more important than urease for acid resistance and intracellular survival in Laribacter hongkongensis: a possible result of arc gene cassette duplication., BMC microbiology. 2014, 14http://www.biomedcentral.com/1471-2180/14/42. |
| Researcher : YANG Z |
| List of Research Outputs |
| YANG Z., Li J., YUAN T., Chen L.Q., Lou Q., Ying H. and Zhang M., Elicitation of broadly neutralizing HIV-1 antibodies by guiding the immune responses using primary and secondary immunogens , AIDS Vaccine 2013. |
| Researcher : YUAN T |
| List of Research Outputs |
| YANG Z., Li J., YUAN T., Chen L.Q., Lou Q., Ying H. and Zhang M., Elicitation of broadly neutralizing HIV-1 antibodies by guiding the immune responses using primary and secondary immunogens , AIDS Vaccine 2013. |
| YUAN T., Li J. and Zhang M., HIV-1 envelope glycoprotein variable loops are indispensable for envelope structural integrity and virus entry, PLoS One. 2013. |
| ZHANG Y., YUAN T., Li J., Zhang Y., Xu J., Shao Y., Chen Z. and Zhang M., The potential of the human immune system to develop broadly neutralizing HIV-1 antibodies: implications for vaccine development, In: JA Levy, AIDS. 2013, 27: 2529-2539. |
| Researcher : Yam WC |
| List of Research Outputs |
| Chen J.H.K., Yam W.C., Ngan A.H.Y., Fung A.M.Y., Woo W.L., Yan M.K., Choi G.K.Y., Ho P.L., Cheng V.C.C. and Yuen K.Y., Advantages of Using Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry as a Rapid Diagnostic Tool for Identification of Yeasts and Mycobacteria in the Clinical Microbiological Laboratory, Journal of Clinical Microbiology. 2013, 51: 3981-3987. |
| Ho P.L., Lo W.U., Chan J., CHEUNG Y.Y., Chow K.H., Yam W.C., Lin C. and Que T.L., pIMP-PH114 carrying bla IMP-4 in a Klebsiella pneumoniae strain is closely related to other multidrug-resistant IncA/C2 plasmids., Current Microbiology. Springer US, 2014, 68(2): 227-232. |
| LAN Y., Lam T.H., Siu G.K.H., Yam W.C., Mason A.J. and Lam J.K.W., In vitro and ex vivo activity of D-antimicrobial peptides against drug resistant mycobacterium tuberculosis, 18th Research Postgraduate Symposium, December 11-12, 2013, Hong Kong. 2013. |
| Lam T.H., Lui E., Chau S., Kueh C.S., Yung Y.K. and Yam W.C., Evaluation of real-time PCR for quantitative detection of Escherichia coli in beach water, J Water Health. 2014, 12(1): 51-6. |
| To S., Chen J.H.K., Wong K., Chan K., Chen Z. and Yam W.C., Determination of the High Prevalence of Dual/Mixed- or X4-Tropism Among HIV Type 1 CRF01_AE in Hong Kong by Genotyping and Phenotyping Methods, AIDS Research and Human Retroviruses. 2013, 29: 1123-1128. |
| To W.C.S., Chen J.H.K., Wong K.H., Chan K.C.W., Ng H.M., Wu H., Lam T.H. and Yam W.C., Performance comparison of an in-house integrase genotyping assay versus the ViroSeq (TM) Integra48, and study of HIV-1 integrase polymorphisms in Hong Kong, In: To SW, Chen JH, Wong KH, Chan KC, Ng HM, Wu H, Lam JT, Yam WC, J Clin Virol. 2013, 58(1): 299-302. |
| To W.C.S., Chen J.H.K., Wong K.H., Chan K.C.W., Ng H.M., Wu H., Lam J.T. and Yam W.C., Performance comparison of an in-house integrase genotyping assay versus the ViroSeq™ Integra48, and study of HIV-1 integrase polymorphisms in Hong Kong, Journal of Clinical Virology. 2013, 58: 299-302. |
| Researcher : Yeung MC |
| List of Research Outputs |
| Siu K.L., Yeung M.C., Kok K.H., Yuen K.S., Kew C., Lui P.Y., Chan C.P., Tse H., Woo P.C.Y., Yuen K.Y. and Jin D., Middle East respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in innate antiviral response, Journal of Virology . 2014, 88: 4866-4876. |
| Researcher : Yeung ML |
| Project Title: | Dissecting the roles of tryptophanyl-tRNA synthetase and other host factors contributory to Enterovirus 71 (EV71) replication |
| Investigator(s): | Yeung ML, Yip CY |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 01/2013 |
| List of Research Outputs |
| KEW C., Siu K.L., Yeung M.L., Chan C.P., Jin D. and Kok K.H., Interplays between RNA-binding proteins determine viral infection outcome , RNA 2014: The 19th Annual Meeting of the RNA Society. Quebec City, Canada, June 3-8, 2014. |
| Researcher : Yeung MY |
| List of Research Outputs |
| Lau S.K.P., Chow W.N., Wong Y.P., Yeung M.Y., Bao Y., Zhang N., Lok S., Woo P.C.Y. and Yuen K.Y., Identification of MicroRNA-like RNAs in Mycelial and yeast phases of the thermal dimorphic fungus Penicillium marneffei, PLoS Neglected Tropical Diseases. 2013, 7: e2398. |
| Researcher : Yip CY |
| Project Title: | Complete genome sequence analysis of human enterovirus 71 strains from 2004 to 2010 in Hong Kong |
| Investigator(s): | Yip CY, Lau SKP, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Mini Grants |
| Start Date: | 11/2011 |
| Completion Date: | 08/2014 |
| List of Research Outputs |
| Lau S.K.P., Woo P.C.Y., Yip C.Y., BAI R., WU Y., Tse H. and Yuen K.Y., Complete genome sequence of a novel feline astrovirus from domestic cat in Hong Kong, Genome Announcements . 2013, 1: e00708-13. |
| Woo P.C.Y., Lau S.K.P., Wernery U., Wong Y.M., Tsang K.L., Johnson B., Yip C.Y., Lau C.Y., Sivakumar S., Cai J., Fan Y.Y., Chan K.H., Mareena R. and Yuen K.Y., Novel betacoronavirus in dromedaries of the Middle East, 2013, Emerging Infectious Diseases. 2014, 20: 560-572. |
| Yip C.Y., Lau S.K.P., Lo J.Y.C., Chan K.H., Woo P.C.Y. and Yuen K.Y., Genetic characterization of EV71 isolates from 2004 to 2010 reveals predominance and persistent circulation of the newly proposed genotype D and recent emergence of a distinct lineage of subgenotype C2 in Hong Kong, Virology Journal. 2013, 10: 222. |
| Yip C.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Human enterovirus 71 epidemics: what's next?, Emerging Health Threats Journal. 2013, 6: 19780. |
| Yip C.Y., Lau S.K.P., Woo P.C.Y., Wong S.S.Y., Tsang T.H.F., Lo J.Y.C., Lam W.K., Tsang C.C., Chan K.H. and Yuen K.Y., Recombinant Coxsackievirus A2 and Deaths of Children, Hong Kong, 2012, Emerging Infectious Diseases. 2013, 19: 1285-1288. |
| Researcher : Yuen K.Y. |
| Project Title: | Establishment of core facilities for the HKU HIV/AIDS research laboratories |
| Investigator(s): | Yuen KY, Zheng B, Woo PCY, Yam WC, Im SWK |
| Department: | Microbiology |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 11/2001 |
| Project Title: | Bacteraemia caused by Anaerotruncus colihominis and emended description of the species |
| Investigator(s): | Yuen KY, Lau SKP, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2005 |
| Project Title: | Investigation of invasive Lasiodiplodia theobromae infections in humans |
| Investigator(s): | Yuen KY, Tse H, Woo PCY, Lau SKP |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2007 |
| Project Title: | Molecular epidemiological investigation of PARV-4-related viruses in HK and southern China |
| Investigator(s): | Yuen KY, Tse H, Lau SKP, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 10/2008 |
| Project Title: | Infection and Immunology |
| Investigator(s): | Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 11/2008 |
| List of Research Outputs |
| Researcher : Yuen KY |
| Project Title: | Establishment of core facilities for the HKU HIV/AIDS research laboratories |
| Investigator(s): | Yuen KY, Zheng B, Woo PCY, Yam WC, Im SWK |
| Department: | Microbiology |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 11/2001 |
| Project Title: | Bacteraemia caused by Anaerotruncus colihominis and emended description of the species |
| Investigator(s): | Yuen KY, Lau SKP, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2005 |
| Project Title: | Investigation of invasive Lasiodiplodia theobromae infections in humans |
| Investigator(s): | Yuen KY, Tse H, Woo PCY, Lau SKP |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2007 |
| Project Title: | Molecular epidemiological investigation of PARV-4-related viruses in HK and southern China |
| Investigator(s): | Yuen KY, Tse H, Lau SKP, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 10/2008 |
| Project Title: | Infection and Immunology |
| Investigator(s): | Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 11/2008 |
| List of Research Outputs |
| Chan J.F.W., Chan K.H., Kao R.Y.T., To K.K.W., Zheng B., Li P.Y., Li T.W., Dai J., Mok K.Y., Chen H., Hayden F.G. and Yuen K.Y., Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus., Journal of Infection. 2013, 67(6): 606-16. |
| Chan J.F.W., Teng L.L., Li W.S., Wong S.C.Y., Leung S.S.M., Ho P.O., To K.K.W., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Fatal empyema thoracis caused by Schizophyllum commune with cross-reactive cryptococcal antigenemia, Journal of Clinical Microbiology . 2014, 52: 683-687. |
| Chan J.F.W., Chan K.H. and Yuen K.Y., Reply to Leow., The Journal of infectious diseases. 2013, 208(8): 1351-1352. |
| Chan J.F.W., Lau S.K.P., Wong S.C.Y., To K.K.W., Cheng V.C.C., Yuen K.Y. and Woo P.C.Y., Ten-year retrospective case series of patients with galactomannan antigenemia: implications on the use of serum galactomannan antigen in the diagnosis of invasive and non-invasive aspergillosis, ECCMID 2014, European Society of Clinical Microbiology and Infectious Diseases. 2014. |
| Chan K.H., To K.K.W., Chan J.F.W., Li P.Y., Chen H. and Yuen K.Y., Analytical Sensitivity of Seven Point-of-Care Influenza Virus Detection Tests and Two Molecular Tests for Detection of Avian Origin H7N9 and Swine Origin H3N2 Variant Influenza A Viruses, Journal of Clinical Microbiology. 2013, 51(9): 3160-3161. |
| Chan K.H., To K.K.W., Chan J.F.W., Li P.Y., Chan K.M., Chen H., Ho P.L. and Yuen K.Y., Assessment of Antigen and Molecular Tests with Serial Specimens from a Patient with Influenza A(H7N9) Infection, Journal of Clinical Microbiology. 2014, 52(6): 2272-2274. |
| Chan S.S.C., Leung D.Y., Leung A.Y.M., Lam C.L.K., Hung I.F.N., Chu D., Chan C.K., Johnston J.M., Liu S.H., Liang R.H.S., Lam T.H. and Yuen K.Y., A nurse-delivered brief health education intervention to improve pneumococcal vaccination rate among older patients with chronic diseases: A cluster randomized controlled trial., International journal of nursing studies. 2014. |
| Chen J.H.K., Yam W.C., Ngan A.H.Y., Fung A.M.Y., Woo W.L., Yan M.K., Choi G.K.Y., Ho P.L., Cheng V.C.C. and Yuen K.Y., Advantages of Using Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry as a Rapid Diagnostic Tool for Identification of Yeasts and Mycobacteria in the Clinical Microbiological Laboratory, Journal of Clinical Microbiology. 2013, 51: 3981-3987. |
| Cheng V.C.C., Chan J.F.W., To K.K.W. and Yuen K.Y., Clinical management and infection control of SARS: lessons learned., Antiviral research. 2013, 100(2): 407-419. |
| Cheng V.C.C., Wong S.C.Y., Sridhar S., Chan J.F.W., Ng M.L.M., Lau S.K.P., Woo P.C.Y., Lo E.C.M., Chan K.K.C. and Yuen K.Y., Management of an incident of failed sterilization of surgical instruments in a dental clinic in Hong Kong, Journal of the Formosan Medical Association. 2013, 112: 666-675. |
| Cheng V.C.C., Tai J.W.M., Chau P.H., Chen J.H.K., Yan M.K., So S.Y.C., To K.K.W., Chan J.F.W., Wong S.C.Y., Ho P.L. and Yuen K.Y., Minimal intervention for controlling nosocomial transmission of Methicillin-Resistant Staphylococcus aureus in resource limited setting with high endemicity, PLoS One. 2014, 9: e100493. |
| Cheng V.C.C., Tai J.W.M., Chen J.H.K., So S.Y., Ng W.C., Hung I.F.N., Leung S.S., Wong S.C.Y., Chan T.C., Chan F.H., Ho P.L. and Yuen K.Y., Proactive infection control measures to prevent nosocomial transmission of vancomycin-resistant enterococci in Hong Kong.ournal of the Formosan Medical Association, Journal of the Formosan Medical Association. 2014. |
| Chu H., Zhou J., Wong H.Y.B., Li C., Cheng Z., Lin X., Poon K.M., Sun T., Lau C.Y., Chan J.F.W., To K.K.W., Chan K.H., Lu L., Zheng B. and Yuen K.Y., Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response. , Virology. 2014, 454-455: 197-205. |
| Hung I.F.N., Li T.W., To K.K.W., Ho T.Y., Chan J.F.W., Chan K.H. and Yuen K.Y., Efficacy of Combined Influenza and 23-valent Polysaccharide Pneumococcal Vaccines in Chronic Smoker, Pathogenesis of Respiratory Viruses at Keystone Resort, Colorado, USA, 19-24 January 2014. |
| Hung I.F.N. and Yuen K.Y., Response, Chest. 2014, 145(2): 435. |
| Jiang L., Wang N., Zuo T., Shi X., Poon K.M., Wu Y., Gao F., Li D., Wang R., Guo J., Fu L., Yuen K.Y., Zheng B., Wang X. and Zhang L., Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein, Sci Transl Med. 2014, 6(234): 234ra59. |
| Lam C.W., Law C.Y., To K.K., Cheung S.K., Lee K.C., Sze K.H., Leung K.F. and Yuen K.Y., NMR-based metabolomic urinalysis: A rapid screening test for urinary tract infection, In: Lam CW, Law CY, To KK, Cheung SK, Lee KC, Sze KH, Leung KF, Yuen KY, Clin Chim Acta. 2014, 436: 217–223. |
| Lam C.W., Law C.Y., To K.K.W., Cheung K.K., Lee K.C., Sze K.H. and Yuen K.Y., Springer Poster Prize For Outstanding Poster Presentation Of Research In The Field Of Metabolomics In The Metabolomics Society 2013 Conference , Metabolomics Society 2013 Conference . 2013. |
| Lau S.K.P., Woo P.C.Y., Yip C.Y., BAI R., WU Y., Tse H. and Yuen K.Y., Complete genome sequence of a novel feline astrovirus from domestic cat in Hong Kong, Genome Announcements . 2013, 1: e00708-13. |
| Lau S.K.P., Lau C.Y., Chan K.H., Li P.Y., Chen H., Jin D., Chan J.F.W., Woo P.C.Y. and Yuen K.Y., Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment, Journal of General Virology. 2013, 94: 2679-2690. |
| Lau S.K.P., Li K.S.M., Tsang K.L., Lam S.F., Ahmed S.S., Chen H., Chan K.H., Woo P.C.Y. and Yuen K.Y., Genetic Characterization of Betacoronavirus Lineage C Viruses in Bats Reveals Marked Sequence Divergence in the Spike Protein of Pipistrellus Bat Coronavirus HKU5 in Japanese Pipistrelle: Implications for the Origin of the Novel Middle East Respiratory Syndrome Coronavirus, Journal of Virology. 2013, 87: 8638-8650. |
| Lau S.K.P., Woo P.C.Y., WU Y., WONG Y.P., Wong B.H.L., Lau C.Y., Fan Y.Y., Cai J., Tsoi H.W., Chan K.H. and Yuen K.Y., Identification and characterization of a novel paramyxovirus, porcine parainfluenza 1 virus, from deceased pigs, Journal of General Virology. 2013, 94: 2184-2190. |
| Lau S.K.P., Chow W.N., Wong Y.P., Yeung M.Y., Bao Y., Zhang N., Lok S., Woo P.C.Y. and Yuen K.Y., Identification of MicroRNA-like RNAs in Mycelial and yeast phases of the thermal dimorphic fungus Penicillium marneffei, PLoS Neglected Tropical Diseases. 2013, 7: e2398. |
| Lau S.K.P., Tang B.S.F., Teng L.L., Chan T.M., Curreem S.O.T., Fan Y.Y., Ng R.H.Y., Chan J.F.W., Yuen K.Y. and Woo P.C.Y., Matrix-assisted laser desorption ionisation time-of-flight mass spectrometry for identification of clinically significant bacteria that are difficult to identify in clinical laboratories, Journal of Clinical Pathology . 2014, 67: 361-366. |
| Lau S.K.P., Tse H., CHAN S.Y.J., Zhou A.C., Curreem S.O.T., Lau C.Y., Yuen K.Y. and Woo P.C.Y., Proteome profiling of the dimorphic fungus Penicillium marneffei extracellular proteins and identification of glyceraldehyde-3-phosphate dehydrogenase as an important adhesion factor for conidial attachment, FEBS Journal . 2013, 280: 6613-6626. |
| Lau S.K.P., Curreem S.O.T., Lin C.C.N., Fung A.M.Y., Yuen K.Y. and Woo P.C.Y., Streptococcus hongkongensis sp. nov., isolated from a patient with an infected puncture wound and from a marine flatfish., International Journal of Systematic and Evolutionary Microbiology. 2013, 63: 2570-2576. |
| Liu R., To K.K.W., Teng L.L., Choi K.Y., Mok K.Y., Law K.I., Tso E.Y., Fung K.S., Wu T.C., Wu A.K.L., Fung S.H., Wong S.C.Y., Trendell-Smith N.J. and Yuen K.Y., Mycobacterium abscessus bacteremia after receipt of intravenous infusate of cytokine-induced killer cell therapy for body beautification and health boosting., Clinical infectious diseases. 2013, 57(7): 981-991. |
| Lu L., Liu Q., Zhu Y., Chan K.H., Qin L., Li Y., Wang Q., Chan J.F.W., Du L., Yu F., Ma C., Ye S., Yuen K.Y., Zhang R. and Jiang S., Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor., Nature communications. 2014. |
| Siu K.L., Yeung M.C., Kok K.H., Yuen K.S., Kew C., Lui P.Y., Chan C.P., Tse H., Woo P.C.Y., Yuen K.Y. and Jin D., Middle East respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in innate antiviral response, Journal of Virology . 2014, 88: 4866-4876. |
| Song W., Wang P., Chen Y., Yang S., Wu N., Lau S.Y., Wu W.L., Mok B.W.Y., Cui D., Huo Z., Zheng M., Huang X., Li L., Yuen K.Y. and Chen H., Mammalian adaptation markers in avian-origin H7N9 virus, a comprehensive investigation in isolates and clinical specimens from the H7N9 influenza affected area, VIII Options for the control of influenza, Cape Town, South Africa, September 2013. |
| Sridhar S., Chan J.F.W. and Yuen K.Y., First report of brain abscess caused by a satelliting phenotypic variant of Helcococcus kunzii., Journal of clinical microbiology. 2013, 52(1): 370-373. |
| Tam W.T., Chen J.H.K., Lau E.C.L., Ngan A.H.Y., Fung K.S.C., Lee K.C., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Misidentification of Aspergillus nomius and Aspergillus tamarii as Aspergillus flavus: Characterization by Internal Transcribed Spacer, -Tubulin, and Calmodulin Gene Sequencing, Metabolic Fingerprinting, and Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry, In: Tam EW, Chen JH, Lau EC, Ngan AH, Fung KS, Lee KC, Lam CW, Yuen KY, Lau SK, Woo PC, Journal of Clinical Microbiology. 2014, 52: 1153-1160. |
| Tam W.T., Chen J.H.K., Lau E.C., Ngan A.H., Fung K.S., Lee K.C., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Misidentification of Aspergillus nomius and Aspergillus tamarii as Aspergillus flavus: characterization by internal transcribed spacer, β-Tubulin, and calmodulin gene sequencing, metabolic fingerprinting, and matrix-assisted laser desorption ionization-time of flight mass spectrometry, In: Tam EW, Chen JH, Lau EC, Ngan AH, Fung KS, Lee KC, Lam CW, Yuen KY, Lau SK, Woo PC, J Clin Microbiol. 2014. |
| Tang B.S.F., Lau S.K.P., Teng L.L., Chan T.M., Chan W.S., Wong T.Y., Tong Y.T., Fan Y.Y., Yuen K.Y. and Woo P.C.Y., Matrix-assisted laser desorption ionisation-time of flight mass spectrometry for rapid identification of Laribacter hongkongensis, Journal of Clinical Pathology . 2013, 66: 1081-1083. |
| To K.K.W., TSANG K.L., Chan J.F.W., Cheng V.C.C., Chen H. and Yuen K.Y., Emergence in China of human disease due to avian influenza A(H10N8) - Cause for concern?, Journal of Infection. 2014, 68(3): 205-215. |
| To K.K.W., Zhou J., Song Y., Hung I.F.N., Ip W.C.T., Cheng Z., Chan S.F., Kao R.Y.T., Wu A.K.L., Chau S.S., Luk W.K., Ip M.S.M., Chan K.H. and Yuen K.Y., Surfactant protein B gene polymorphism is associated with severe influenza., Chest. 2014, 145(6): 1237-1243. |
| To K.K.W., Chan J.F.W., Chen H., Li L.J. and Yuen K.Y., The emergence of influenza A H7N9 in human beings 16 years after influenza A H5N1: a tale of two cities, Lancet Infectious Diseases. 2013, 13(9): 809-821. |
| To K.K.W., Chan J.F.W. and Yuen K.Y., Viral lung infections: epidemiology, virology, clinical features, and management of avian influenza A(H7N9)., Current opinion in pulmonary medicine. 2014, 20(3): 225-232. |
| Tse M.K., Cheung K.K., Ke Y., Lau C.Y., Sze K.H. and Yuen K.Y., Backbone and side-chain ¹H, ¹³C and ¹⁵N assignments of the PPIase domain of macrophage infectivity potentiator (Mip) protein from Coxiella burnetii., Biomolecular NMR assignments. 2014, 8(1): 173-176. |
| WEN X., HUANG X., Mok B.W.Y., Chen Y.X., ZHENG M., Lau S.Y., Wang P., Song W., Jin D., Yuen K.Y. and Chen H., NF90 Exerts Antiviral Activity through Regulation of PKR Phosphorylation and Stress Granules in Infected Cells, Journal of Immunology. 2014, 192(8): 3753-3764. |
| Wong S.S.W., Kao R.Y.T., Yuen K.Y., Wang Y., Yang D., Samaranayake L.P. and Seneviratne C.J., In vitro and In vivo activity of a novel antifungal small molecule against Candida infections, PloS one. 2014, 9(1): e85836. |
| Wong S.S.Y., Fung K.S., Chau S., Poon W.S.R., Wong S.C.Y. and Yuen K.Y., Molecular diagnosis in clinical parasitology: When and why?, Experimental biology and medicine. 2014. |
| Woo P.C.Y., Lau S.K.P., Lam S.F., Tsang K.L., Hui S.W., Fan Y.Y., Martelli P. and Yuen K.Y., Discovery of a novel bottlenose dolphin coronavirus reveals a distinct species of marine mammal coronavirus in Gammacoronavirus, Journal of Virology . 2014, 88: 1318-1331. |
| Woo P.C.Y., Lau S.K.P., Teng L.L., Tsang K.L., Joseph M., Wong Y.M., TANG Y., Sivakumar S., Xie J., BAI R., Wernery R., Wernery U. and Yuen K.Y., New hepatitis E virus genotype in camel, the Middle East, Emerging Infectious Diseases . 2014, 20: 1044-1048. |
| Woo P.C.Y., Lau S.K.P., Wernery U., Wong Y.M., Tsang K.L., Johnson B., Yip C.Y., Lau C.Y., Sivakumar S., Cai J., Fan Y.Y., Chan K.H., Mareena R. and Yuen K.Y., Novel betacoronavirus in dromedaries of the Middle East, 2013, Emerging Infectious Diseases. 2014, 20: 560-572. |
| Xiao H., Liu L., Zhu Q., Tan Z., Yu W., Tang X., Zhan D., Du D.Y., Wang H., Liu D., Li Z., Jiang X., Yuen K.Y., Ho D., Gao F. and Chen Z., A Replicating Modified Vaccinia Tiantan Strain Expressing an Avian-Derived Influenza H5N1 Hemagglutinin Induce Broadly Neutralizing Antibodies and Cross-Clade Protective Immunity in Mice, PLoS ONE. 2013, 8: e83274. |
| Xu L.L., Bao L.L., Yuan J., Li F.D., Lv Q., Deng W., Xu Y.F., Yao Y.F., Yu P., Chen H., Yuen K.Y. and Qin C., Antigenicity and transmissibility of a novel clade 2.3.2.1 avian influenza H5N1 virus, Journal of General Virology. 2013, 94: 2616-2626. |
| Yang E., Wang G., Woo P.C.Y., Lau S.K.P., Chow W.N., Chong T.K., Tse H., Kao R.Y.T., Chan C.M., Che X., Yuen K.Y. and Cai J.J., Unraveling the molecular basis of temperature-dependent genetic regulation in Penicillium marneffei, Eukaryotic Cell . 2013, 12: 1214-1224. |
| Yang S.G., Chen Y., Cui D.W., Yao H.P., Lou J.Z., Huo Z.X., Xie G.L., Yu F., Zheng S.F., Yang Y.D., Zhu Y.X., Lu X.Q., Liu X.L., Lau S.Y., Chan J.F.W., To K.K.W., Yuen K.Y., Chen H. and Li L.J., Avian-Origin Influenza A(H7N9) Infection in Influenza A(H7N9)-Affected Areas of China: A Serological Study, Journal of Infectious Diseases. 2014, 209(2): 265-269. |
| Yao Y.F., Bao L.L., Deng W., Xu L.L., Li F.D., Lv Q., Yu P., Chen T., Xu Y.F., Zhu H., Yuan J., Gu S.Z., Wei Q., Chen H., Yuen K.Y. and Qin C., An Animal Model of MERS Produced by Infection of Rhesus Macaques With MERS Coronavirus, Journal of Infectious Diseases. 2014, 209(2): 236-242. |
| Yip C.Y., Lau S.K.P., Lo J.Y.C., Chan K.H., Woo P.C.Y. and Yuen K.Y., Genetic characterization of EV71 isolates from 2004 to 2010 reveals predominance and persistent circulation of the newly proposed genotype D and recent emergence of a distinct lineage of subgenotype C2 in Hong Kong, Virology Journal. 2013, 10: 222. |
| Yip C.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Human enterovirus 71 epidemics: what's next?, Emerging Health Threats Journal. 2013, 6: 19780. |
| Yip C.Y., Lau S.K.P., Woo P.C.Y., Wong S.S.Y., Tsang T.H.F., Lo J.Y.C., Lam W.K., Tsang C.C., Chan K.H. and Yuen K.Y., Recombinant Coxsackievirus A2 and Deaths of Children, Hong Kong, 2012, Emerging Infectious Diseases. 2013, 19: 1285-1288. |
| Yu L., Wang Z.M., Chen Y., Ding W., Jia H.Y., Chan J.F.W., To K.K.W., Chen H., Yang Y.D., Liang W.F., Zheng S.F., Yao H.P., Yang S.G., Cao H.C., Dai X.H., Zhao H., Li J., Bao Q.L., Chen P., Hou X.L., Li L.J. and Yuen K.Y., Clinical, Virological, and Histopathological Manifestations of Fatal Human Infections by Avian Influenza A(H7N9) Virus, Clinical Infectious Diseases. 2013, 57(10): 1449-1457. |
| Yuen K.Y., Solving the mystery of H7N9 by crystal balls., Cell research. 2013, 23(12): 1335-1336. |
| Zhang J., Li C., To K.K.W., Zhu H., Lee C.Y., Li C., Chan J.F.W., Hung I.F.N. and Yuen K.Y., Toll-like receptor 7 agonist imiquimod in combination with influenza vaccine expedites and augments humoral immune responses against influenza A(H1N1)pdm09 virus infection in BALB/c mice., Clinical and vaccine immunology. 2014, 21(4): 570-579. |
| Zhou J., Chu H., Li C., Wong H.Y.B., Cheng Z., Poon K.M., Sun T., Lau C.Y., Wong K.K., Chan J.Y.K., Chan J.F.W., To K.K.W., Chan K.H., Zheng B. and Yuen K.Y., Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis., J Infect Dis. 2014, 209(9): 1331-42. |
| Zhu X., Guo Y.H., Jiang T., Wang Y.D., Chan K.H., Li X.F., Yu W., McBride R., Paulson J.C., Yuen K.Y., Qin C.F., Che X.Y. and Wilson I.A., A unique and conserved neutralization epitope in H5N1 influenza viruses identified by an antibody against the A/Goose/Guangdong/1/96 hemagglutinin., Journal of virology. 2013, 87(23): 12619-12635. |
| Researcher : ZHANG N |
| List of Research Outputs |
| ZHANG N., LIN Y., Chen M., LEUNG H.C., Chan C.S., Poon K.M., Zhou J., Cheung C.Y., Lu L. and Zheng B., Pandemic A/H1N1 2009 Influenza Virus-like Particles Elicited Higher and Broader Immune Responses than the Commercial Panenza Vaccine., J Pharm Pharmaco. 2014, 2(2014): 50-58. |
| Researcher : ZHANG Y |
| List of Research Outputs |
| CHEN C., ZHANG Y., ZHANG Y., Li J., Tsao G.S.W. and Zhang M., Superior Antitumor Activity of a Novel Bispecific Antibody Cotargeting Human Epidermal Growth Factor Receptor 2 and Type I Insulin-like Growth Factor Receptor, Molecular Cancer Therapeutics. 2013, 13: 90-100. |
| ZHANG Y., YUAN T., Li J., Zhang Y., Xu J., Shao Y., Chen Z. and Zhang M., The potential of the human immune system to develop broadly neutralizing HIV-1 antibodies: implications for vaccine development, In: JA Levy, AIDS. 2013, 27: 2529-2539. |
| Researcher : ZHANG Y |
| List of Research Outputs |
| CHEN C., ZHANG Y., ZHANG Y., Li J., Tsao G.S.W. and Zhang M., Superior Antitumor Activity of a Novel Bispecific Antibody Cotargeting Human Epidermal Growth Factor Receptor 2 and Type I Insulin-like Growth Factor Receptor, Molecular Cancer Therapeutics. 2013, 13: 90-100. |
| ZHANG Y., YUAN T., Li J., Zhang Y., Xu J., Shao Y., Chen Z. and Zhang M., The potential of the human immune system to develop broadly neutralizing HIV-1 antibodies: implications for vaccine development, In: JA Levy, AIDS. 2013, 27: 2529-2539. |
| Researcher : ZHENG M |
| List of Research Outputs |
| Song W., Wang P., Chen Y., Yang S., Wu N., Lau S.Y., Wu W.L., Mok B.W.Y., Cui D., Huo Z., Zheng M., Huang X., Li L., Yuen K.Y. and Chen H., Mammalian adaptation markers in avian-origin H7N9 virus, a comprehensive investigation in isolates and clinical specimens from the H7N9 influenza affected area, VIII Options for the control of influenza, Cape Town, South Africa, September 2013. |
| WEN X., HUANG X., Mok B.W.Y., Chen Y.X., ZHENG M., Lau S.Y., Wang P., Song W., Jin D., Yuen K.Y. and Chen H., NF90 Exerts Antiviral Activity through Regulation of PKR Phosphorylation and Stress Granules in Infected Cells, Journal of Immunology. 2014, 192(8): 3753-3764. |
| Researcher : ZHOU J |
| List of Research Outputs |
| Bao S., Zhou X.Y., Zhang L.C., Zhou J., To K.K.W., Wang B., Wang L., Zhang X. and Song Y., Prioritizing genes affecting host resistance to influenza by network approaches, BMC Genomics . 2013, 14(1): 816. |
| Bao S., Zhou X., Zhang L., Zhou J., To K.K.W., Wang B., Wang L., Zhang X. and Song Y., Prioritizing genes responsible for host resistance to influenza using network approaches.BMC genomics, BMC genomics. 2013. |
| Chu H., Zhou J., Wong H.Y.B., Li C., Cheng Z., Lin X., Poon K.M., Sun T., Lau C.Y., Chan J.F.W., To K.K.W., Chan K.H., Lu L., Zheng B. and Yuen K.Y., Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response. , Virology. 2014, 454-455: 197-205. |
| Tang V.H.M., GAO W., CHENG Y., Zhou J. and Jin D., CRTC coactivators are required for hepatitis B virus transcription , The 14th Society of Chinese Bioscientists in America International Symposium, Xi’an, Shaanxi, China July 18-22, 2013. |
| Tang V.H.M., GAO W., CHENG Y., Kok K.H., Zhou J. and Jin D., CRTC coactivators are required for hepatitis B virus transcription, The 14th SCBA International Symposium. 2013. |
| To K.K.W., Zhou J., Song Y., Hung I.F.N., Ip W.C.T., Cheng Z., Chan S.F., Kao R.Y.T., Wu A.K.L., Chau S.S., Luk W.K., Ip M.S.M., Chan K.H. and Yuen K.Y., Surfactant protein B gene polymorphism is associated with severe influenza., Chest. 2014, 145(6): 1237-1243. |
| ZHANG N., LIN Y., Chen M., LEUNG H.C., Chan C.S., Poon K.M., Zhou J., Cheung C.Y., Lu L. and Zheng B., Pandemic A/H1N1 2009 Influenza Virus-like Particles Elicited Higher and Broader Immune Responses than the Commercial Panenza Vaccine., J Pharm Pharmaco. 2014, 2(2014): 50-58. |
| ZHOU J., Cheung K.L.A., Liu H., TAN Z., TANG X., KANG Y., Du Y., Wang H., Liu L. and Chen Z., Potentiating Functional Antigen-specific CD8+ T Cell Immunity by a Novel PD1 Isoform-based Fusion DNA Vaccine, Molecular Therapy. 2013, 21: 1445-1455. |
| Zhou J., Chu H., Li C., Wong H.Y.B., Cheng Z., Poon K.M., Sun T., Lau C.Y., Wong K.K., Chan J.Y.K., Chan J.F.W., To K.K.W., Chan K.H., Zheng B. and Yuen K.Y., Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis., J Infect Dis. 2014, 209(9): 1331-42. |
| Researcher : Zhang H |
| Project Title: | the 1st european conference of microbiology and immunology Low Th17 expression association with Chronic Hepatitis B viral infection by means of reducing viral specific IFNγ releasing in a HBV infection model of IL-17 KO mice |
| Investigator(s): | Zhang H |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2011 |
| Researcher : Zhang J |
| Project Title: | Imiquimod accelarets protective immune responses induced by inactivated influenza vaccine in BALB/c mice |
| Investigator(s): | Zhang J |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2012 |
| Completion Date: | 11/2013 |
| Project Title: | The Options fro Control of Inlfuenza VIII; TLR7 agonist imiquimod in combination with inactivated influenza vaccine induces expeditious and augmented immune responses sufficient enough to protect BALB/c mice against immediate lethal virus challenge |
| Investigator(s): | Zhang J |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2013 |
| Completion Date: | 09/2013 |
| List of Research Outputs |
| Zhang J., Li C., To K.K.W., Zhu H., Lee C.Y., Li C., Chan J.F.W., Hung I.F.N. and Yuen K.Y., Toll-like receptor 7 agonist imiquimod in combination with influenza vaccine expedites and augments humoral immune responses against influenza A(H1N1)pdm09 virus infection in BALB/c mice., Clinical and vaccine immunology. 2014, 21(4): 570-579. |
| Researcher : Zhang JX |
| Project Title: | Imiquimod accelarets protective immune responses induced by inactivated influenza vaccine in BALB/c mice |
| Investigator(s): | Zhang J |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2012 |
| Completion Date: | 11/2013 |
| Project Title: | The Options fro Control of Inlfuenza VIII; TLR7 agonist imiquimod in combination with inactivated influenza vaccine induces expeditious and augmented immune responses sufficient enough to protect BALB/c mice against immediate lethal virus challenge |
| Investigator(s): | Zhang J |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2013 |
| Completion Date: | 09/2013 |
| List of Research Outputs |
| Researcher : Zhang M |
| Project Title: | Identification of HIV-1-specific broadly neutralizing human monoclonal antibodies from the B-cell genomic DNA antibody gene repertoires of HIV-1 infected individuals |
| Investigator(s): | Zhang M |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2010 |
| Completion Date: | 11/2013 |
| Project Title: | Reconstitution and Characterization of HIV-specific Antibody Repertoires in vitro: Implications for Passive Immunization |
| Investigator(s): | Zhang M |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 08/2011 |
| Completion Date: | 10/2014 |
| Project Title: | Development of a "Two-in-One" Duel Specific Antibody Therapeutics for Treatment of Breast Cancer |
| Investigator(s): | Zhang M |
| Department: | Microbiology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 11/2011 |
| Project Title: | Development of intrabodies targeting eukaryotic translation initiation factor 5A2 for cancer treatment |
| Investigator(s): | Zhang M, Guan X |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 06/2012 |
| Completion Date: | 12/2013 |
| List of Research Outputs |
| CHEN C., ZHANG Y., ZHANG Y., Li J., Tsao G.S.W. and Zhang M., Superior Antitumor Activity of a Novel Bispecific Antibody Cotargeting Human Epidermal Growth Factor Receptor 2 and Type I Insulin-like Growth Factor Receptor, Molecular Cancer Therapeutics. 2013, 13: 90-100. |
| SUN Z., Li J., Shao Y. and Zhang M., A Novel Methodology for Isolating Broadly Neutralizing HIV-1 Human Monoclonal Antibodies, AIDS Vaccine 2013. |
| YANG Z., Li J., YUAN T., Chen L.Q., Lou Q., Ying H. and Zhang M., Elicitation of broadly neutralizing HIV-1 antibodies by guiding the immune responses using primary and secondary immunogens , AIDS Vaccine 2013. |
| YUAN T., Li J. and Zhang M., HIV-1 envelope glycoprotein variable loops are indispensable for envelope structural integrity and virus entry, PLoS One. 2013. |
| ZHANG Y., YUAN T., Li J., Zhang Y., Xu J., Shao Y., Chen Z. and Zhang M., The potential of the human immune system to develop broadly neutralizing HIV-1 antibodies: implications for vaccine development, In: JA Levy, AIDS. 2013, 27: 2529-2539. |
| Zhang M., Editorial Board Member, Journal of Virology and Retrovirology. 2013. |
| Researcher : Zhang Y |
| List of Research Outputs |
| CHEN C., ZHANG Y., ZHANG Y., Li J., Tsao G.S.W. and Zhang M., Superior Antitumor Activity of a Novel Bispecific Antibody Cotargeting Human Epidermal Growth Factor Receptor 2 and Type I Insulin-like Growth Factor Receptor, Molecular Cancer Therapeutics. 2013, 13: 90-100. |
| ZHANG Y., YUAN T., Li J., Zhang Y., Xu J., Shao Y., Chen Z. and Zhang M., The potential of the human immune system to develop broadly neutralizing HIV-1 antibodies: implications for vaccine development, In: JA Levy, AIDS. 2013, 27: 2529-2539. |
| Researcher : Zheng B |
| Project Title: | CCR5 expression on antigen-presenting cens in HIV infection |
| Investigator(s): | Zheng B, Lee SS |
| Department: | Microbiology |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 01/2001 |
| Project Title: | The pattern of chemokine receptor polymorphism in healthy and HIV positive Chinese adults |
| Investigator(s): | Zheng B, Lee SS |
| Department: | Microbiology |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 01/2001 |
| Project Title: | A longitudinal study of HIV-1 drug-resistance for improving management of patients on HARRT (MSS 140R) |
| Investigator(s): | Zheng B, Lu L, Chan KW |
| Department: | Microbiology |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 07/2006 |
| Project Title: | Study of vaccine HA-M2 against H5N1 avian influenza virus |
| Investigator(s): | Zheng B |
| Department: | Microbiology |
| Source(s) of Funding: | Matching Fund for Hi-Tech Research and Development Program of China (863 Projects) |
| Start Date: | 08/2007 |
| Project Title: | Study of AAV- and peptide-based vaccine candidates against influenza virus H5N1 infection in animal model |
| Investigator(s): | Zheng B, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 11/2007 |
| Project Title: | Cross-protective efficacy of immunization with different forms of M2 vaccines and their combinations with HA vaccines against highly pathogenic H5N1 influenza A viruses in mice |
| Investigator(s): | Zheng B, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 10/2009 |
| Project Title: | Co-administration of antiviral and anti-inflammatory agents against avian influenza virus H5N1 infection in animal model |
| Investigator(s): | Zheng B, Yuen KY, Jin D |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2010 |
| Completion Date: | 08/2014 |
| Project Title: | A feasibility study on anti-H5N1 influenza viral infection using aptamers targeting viral nucleoprotein |
| Investigator(s): | Zheng B, Zhou J |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 11/2011 |
| Completion Date: | 09/2014 |
| Project Title: | Development of Antiviral Agents based on Small RNA Containing Unique Motif |
| Investigator(s): | Zheng B, Zhou J |
| Department: | Microbiology |
| Source(s) of Funding: | Matching Grant for Joint Research |
| Start Date: | 05/2012 |
| Project Title: | Development of Antiviral Agents based on Small RNA Containing Unique Motif (UIM/215) |
| Investigator(s): | Zheng B, Zhou J |
| Department: | Microbiology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 05/2012 |
| Project Title: | Development of Antiviral Agents based on Small RNA Containing Unique Motif (UIM/215) |
| Investigator(s): | Zheng B, Zhou J |
| Department: | Microbiology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 05/2012 |
| Project Title: | Development of Antiviral Peptides against Infections of Influenza Virus and Other Respiratory Viruses |
| Investigator(s): | Zheng B, Zhou J |
| Department: | Microbiology |
| Source(s) of Funding: | Matching Grant for Joint Research |
| Start Date: | 03/2013 |
| Project Title: | Options for the control of influenza VIII; Cross-protective efficacy of vaccination with different forms of M2 vaccines and their combination with HA vaccines against H5N1 influenza in mice |
| Investigator(s): | Zheng B |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2013 |
| Completion Date: | 09/2013 |
| Project Title: | Development of Antiviral Peptides against Infections of Influenza Virus and Other Respiratory Viruses |
| Investigator(s): | Zheng B, Zhou J |
| Department: | Microbiology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 11/2013 |
| Project Title: | Development of Antiviral Peptides against Infections of Influenza Virus and Other Respiratory Viruses |
| Investigator(s): | Zheng B, Zhou J |
| Department: | Microbiology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 11/2013 |
| List of Research Outputs |
| Chan J.F.W., Chan K.H., Kao R.Y.T., To K.K.W., Zheng B., Li P.Y., Li T.W., Dai J., Mok K.Y., Chen H., Hayden F.G. and Yuen K.Y., Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus., Journal of Infection. 2013, 67(6): 606-16. |
| Chu H., Zhou J., Wong H.Y.B., Li C., Cheng Z., Lin X., Poon K.M., Sun T., Lau C.Y., Chan J.F.W., To K.K.W., Chan K.H., Lu L., Zheng B. and Yuen K.Y., Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response. , Virology. 2014, 454-455: 197-205. |
| Jiang L., Wang N., Zuo T., Shi X., Poon K.M., Wu Y., Gao F., Li D., Wang R., Guo J., Fu L., Yuen K.Y., Zheng B., Wang X. and Zhang L., Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein, Sci Transl Med. 2014, 6(234): 234ra59. |
| Wu R., Li X., LEUNG H.C., Cao Z., Qiu Z., Zhou Y., Zheng B. and He Y., A novel neutralizing antibody against diverse clades of H5N1 influenza virus and its mutants capable of airborne transmission., Antiviral Research . 2014, 106: 13-23. |
| Xiao X.C., Li K.B., Chen Z.Q., Di B., Yang Z.C., Yuan J., Luo H.B., Ye S.L., Liu H., Lu J.Y., Nie Z., Tang X.P., Wang M. and Zheng B., Transmission of avian influenza A(H7N9) virus from father to child: a report of limited person-to-person transmission, Guangzhou, China, January 2014., Eurosurveillance. 2014, 19(25): pii=20837. |
| Yuan J., Tang X., Yang Z., Wang M. and Zheng B., Enhanced disinfection and regular closure of wet markets reduced the risk of avian influenza A virus transmission, Clin Infect Dis. 2014, 58(7): 1037-1038. |
| ZHANG N., LIN Y., Chen M., LEUNG H.C., Chan C.S., Poon K.M., Zhou J., Cheung C.Y., Lu L. and Zheng B., Pandemic A/H1N1 2009 Influenza Virus-like Particles Elicited Higher and Broader Immune Responses than the Commercial Panenza Vaccine., J Pharm Pharmaco. 2014, 2(2014): 50-58. |
| Zhao G., Du L., Ma C., Li Y., Li L., Poon K.M., Wang L., Yu F., Zheng B., Jiang S. and Zhou Y., A safe and convenient pseudovirus-based inhibition assay to detect neutralizing antibodies and screen for viral entry inhibitors against the novel human coronavirus MERS-CoV., Virology Journal. 2013, 10(1): 266. |
| Zhou J., Chu H., Li C., Wong H.Y.B., Cheng Z., Poon K.M., Sun T., Lau C.Y., Wong K.K., Chan J.Y.K., Chan J.F.W., To K.K.W., Chan K.H., Zheng B. and Yuen K.Y., Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis., J Infect Dis. 2014, 209(9): 1331-42. |
| Researcher : Zheng B. |
| Project Title: | CCR5 expression on antigen-presenting cens in HIV infection |
| Investigator(s): | Zheng B, Lee SS |
| Department: | Microbiology |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 01/2001 |
| Project Title: | The pattern of chemokine receptor polymorphism in healthy and HIV positive Chinese adults |
| Investigator(s): | Zheng B, Lee SS |
| Department: | Microbiology |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 01/2001 |
| Project Title: | A longitudinal study of HIV-1 drug-resistance for improving management of patients on HARRT (MSS 140R) |
| Investigator(s): | Zheng B, Lu L, Chan KW |
| Department: | Microbiology |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 07/2006 |
| Project Title: | Study of vaccine HA-M2 against H5N1 avian influenza virus |
| Investigator(s): | Zheng B |
| Department: | Microbiology |
| Source(s) of Funding: | Matching Fund for Hi-Tech Research and Development Program of China (863 Projects) |
| Start Date: | 08/2007 |
| Project Title: | Study of AAV- and peptide-based vaccine candidates against influenza virus H5N1 infection in animal model |
| Investigator(s): | Zheng B, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 11/2007 |
| Project Title: | Cross-protective efficacy of immunization with different forms of M2 vaccines and their combinations with HA vaccines against highly pathogenic H5N1 influenza A viruses in mice |
| Investigator(s): | Zheng B, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 10/2009 |
| Project Title: | Co-administration of antiviral and anti-inflammatory agents against avian influenza virus H5N1 infection in animal model |
| Investigator(s): | Zheng B, Yuen KY, Jin D |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2010 |
| Completion Date: | 08/2014 |
| Project Title: | A feasibility study on anti-H5N1 influenza viral infection using aptamers targeting viral nucleoprotein |
| Investigator(s): | Zheng B, Zhou J |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 11/2011 |
| Completion Date: | 09/2014 |
| Project Title: | Development of Antiviral Agents based on Small RNA Containing Unique Motif |
| Investigator(s): | Zheng B, Zhou J |
| Department: | Microbiology |
| Source(s) of Funding: | Matching Grant for Joint Research |
| Start Date: | 05/2012 |
| Project Title: | Development of Antiviral Agents based on Small RNA Containing Unique Motif (UIM/215) |
| Investigator(s): | Zheng B, Zhou J |
| Department: | Microbiology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 05/2012 |
| Project Title: | Development of Antiviral Agents based on Small RNA Containing Unique Motif (UIM/215) |
| Investigator(s): | Zheng B, Zhou J |
| Department: | Microbiology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 05/2012 |
| Project Title: | Development of Antiviral Peptides against Infections of Influenza Virus and Other Respiratory Viruses |
| Investigator(s): | Zheng B, Zhou J |
| Department: | Microbiology |
| Source(s) of Funding: | Matching Grant for Joint Research |
| Start Date: | 03/2013 |
| Project Title: | Options for the control of influenza VIII; Cross-protective efficacy of vaccination with different forms of M2 vaccines and their combination with HA vaccines against H5N1 influenza in mice |
| Investigator(s): | Zheng B |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2013 |
| Completion Date: | 09/2013 |
| Project Title: | Development of Antiviral Peptides against Infections of Influenza Virus and Other Respiratory Viruses |
| Investigator(s): | Zheng B, Zhou J |
| Department: | Microbiology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 11/2013 |
| Project Title: | Development of Antiviral Peptides against Infections of Influenza Virus and Other Respiratory Viruses |
| Investigator(s): | Zheng B, Zhou J |
| Department: | Microbiology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 11/2013 |
| List of Research Outputs |
| Researcher : Zhou J |
| Project Title: | A feasibility study on the inhibition of respiratory syncytial virus infection using siRNAs with a unique motif |
| Investigator(s): | Zhou J, Zheng B |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2010 |
| Project Title: | A feasibility study on the inhibition of respiratory syncytial virus infection using siRNAs with a unique motif |
| Investigator(s): | Zhou J, Zheng B |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2011 |
| Project Title: | Characterization of KLF15 as a crucial transactivator for hepatitis B virus gene expression and viral replication in vitro and in vivo |
| Investigator(s): | Zhou J, Yuen KY, Zheng B |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2012 |
| Completion Date: | 12/2013 |
| Project Title: | Exploring the role of CD55 in the pathogenesis of influenza virus A infection |
| Investigator(s): | Zhou J, Zheng B |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 01/2013 |
| List of Research Outputs |
| Bao S., Zhou X.Y., Zhang L.C., Zhou J., To K.K.W., Wang B., Wang L., Zhang X. and Song Y., Prioritizing genes affecting host resistance to influenza by network approaches, BMC Genomics . 2013, 14(1): 816. |
| Bao S., Zhou X., Zhang L., Zhou J., To K.K.W., Wang B., Wang L., Zhang X. and Song Y., Prioritizing genes responsible for host resistance to influenza using network approaches.BMC genomics, BMC genomics. 2013. |
| Chu H., Zhou J., Wong H.Y.B., Li C., Cheng Z., Lin X., Poon K.M., Sun T., Lau C.Y., Chan J.F.W., To K.K.W., Chan K.H., Lu L., Zheng B. and Yuen K.Y., Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response. , Virology. 2014, 454-455: 197-205. |
| Tang V.H.M., GAO W., CHENG Y., Zhou J. and Jin D., CRTC coactivators are required for hepatitis B virus transcription , The 14th Society of Chinese Bioscientists in America International Symposium, Xi’an, Shaanxi, China July 18-22, 2013. |
| Tang V.H.M., GAO W., CHENG Y., Kok K.H., Zhou J. and Jin D., CRTC coactivators are required for hepatitis B virus transcription, The 14th SCBA International Symposium. 2013. |
| To K.K.W., Zhou J., Song Y., Hung I.F.N., Ip W.C.T., Cheng Z., Chan S.F., Kao R.Y.T., Wu A.K.L., Chau S.S., Luk W.K., Ip M.S.M., Chan K.H. and Yuen K.Y., Surfactant protein B gene polymorphism is associated with severe influenza., Chest. 2014, 145(6): 1237-1243. |
| ZHANG N., LIN Y., Chen M., LEUNG H.C., Chan C.S., Poon K.M., Zhou J., Cheung C.Y., Lu L. and Zheng B., Pandemic A/H1N1 2009 Influenza Virus-like Particles Elicited Higher and Broader Immune Responses than the Commercial Panenza Vaccine., J Pharm Pharmaco. 2014, 2(2014): 50-58. |
| ZHOU J., Cheung K.L.A., Liu H., TAN Z., TANG X., KANG Y., Du Y., Wang H., Liu L. and Chen Z., Potentiating Functional Antigen-specific CD8+ T Cell Immunity by a Novel PD1 Isoform-based Fusion DNA Vaccine, Molecular Therapy. 2013, 21: 1445-1455. |
| Zhou J., Chu H., Li C., Wong H.Y.B., Cheng Z., Poon K.M., Sun T., Lau C.Y., Wong K.K., Chan J.Y.K., Chan J.F.W., To K.K.W., Chan K.H., Zheng B. and Yuen K.Y., Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis., J Infect Dis. 2014, 209(9): 1331-42. |
| Researcher : Zhu H |
| Project Title: | Evolution and Risk assessment studies for 2009 pandemic-like reassortant swine influenza viruses from China |
| Investigator(s): | Zhu H, Guan Y, Smith DK |
| Department: | School of Public Health |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2012 |
| Project Title: | Options for the Control of Influenza VIII; The emergence of the 2013 H7N9 and related viruses in China (as the presenter) |
| Investigator(s): | Zhu H |
| Department: | School of Public Health |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2013 |
| Completion Date: | 09/2013 |
| Project Title: | Transmissibility and pathogenicity studies of the recent H7N9 human and avian isolates in a ferret model |
| Investigator(s): | Zhu H, Guan Y |
| Department: | School of Public Health |
| Source(s) of Funding: | Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential |
| Start Date: | 06/2014 |
| List of Research Outputs |
| Zhang J., Li C., To K.K.W., Zhu H., Lee C.Y., Li C., Chan J.F.W., Hung I.F.N. and Yuen K.Y., Toll-like receptor 7 agonist imiquimod in combination with influenza vaccine expedites and augments humoral immune responses against influenza A(H1N1)pdm09 virus infection in BALB/c mice., Clinical and vaccine immunology. 2014, 21(4): 570-579. |