SCHOOL OF BIOMEDICAL SCIENCES
| Researcher : Au YK |
| Project Title: | Cartilage Biology & Pathology; Understanding the molecular impact of SOX9Y440X in campomelic dysplasia |
| Investigator(s): | Au YK |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2015 |
| Completion Date: | 03/2015 |
| List of Research Outputs |
| Au Y.K., Wynn S., Szeto Y.Y., Geng Y.H., Tan T.Y., Cheung K.M.C. and Cheah K.S.E., Understanding the Molecular Impact of Sox9 Y440X in Campomelic Dysplasia., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015. |
| Cheah K.S.E., Au Y.K., Wynn S., Tan T.Y. and YIP K.H.R., Sox9 restrains chondrocyte to osteoblast lineage progression-implications for the pathogenesis of Campomelic Dysplasia., International Society for Stem Cell Research, ISSCR 2015 Annual Meeting. Stockholm, Sweden. 24-27 June 2015.. 2015. |
| Szeto Y.Y., Au Y.K., Wu M.H., Dung W.F. and Cheah K.S.E., The role of Zic3 and BAF complex in notochord cell lineage progression, Gordon Research Conference: Genome Architecture in Cell Fate & Disease Hong Kong, Jun 7-12, 2015.. 2015. |
| YIP K.H.R., Au Y.K., Yang W., Chan D. and Cheah K.S.E., Investigating impact of Sox9 dysfunction in hypertrophic chondrocytes-to-osteoblasts transition., Gordon Research Conference: Cartilage Biology and Pathology TX, USA Mar 22-27, 2015.. 2015. |
| Researcher : Bevan SJ |
| List of Research Outputs |
| Bevan S.J., Chan C.W.L. and Tanner J.A., Creative and collaborative assessment strategies sustain deep student learning: Evidence from a large introductory biochemical class., International Conference: Assessment for Learning in Higher Education 2015, Hong Kong. 2015. |
| Bevan S.J., Chan C.W.L. and Tanner J.A., Sustaining deep learning in first year biomedical sciences courses – a quantitative comparative study provides evidence for the benefits of diverse assessment and active student engagement., 12th Asia Pacific Medical Education Conference, Singapore (2015). 2015. |
| Researcher : CHAUDHARY V |
| List of Research Outputs |
| CHAUDHARY V., Best Poster Presentation Award: Suppression of innate interferon production and signaling by NSs protein of severe fever-with-thrombocytopenia syndrome virus, The 15th International Symposium of the Society of Chinese Bioscientists in America. 2015. |
| CHAUDHARY V., Suppression of innate interferon production and signaling by NSs protein of severe fever-with-thrombocytopenia syndrome virus, The 15th International Symposium of the Society of Chinese Bioscientists in America. 2015. |
| Researcher : CHEN X |
| List of Research Outputs |
| CHEN X., XU W., Li N.F. and Chen J., Basic defect in cystic fibrosis, In: Burkhard Tümmler, Mutation-specific therapies in cystic fibrosis - Current status and prospects. Bremen, UNI-MED Science, 2014, 1st edition: 21-23. |
| CHEN X. and Chen J., Deletions of the Y512 and F508 residues in the cystic fibrosis transmembrane conductance regulator may cause similar structural defects affecting protein processing, The 10th International Symposium on Healthy Aging, Hong Kong. 2015. |
| Researcher : CHENG Y |
| List of Research Outputs |
| CHENG Y., Tang H.M.V., GAO W., Deng J., Chan C.P. and Jin D., bTrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H, The 15th International Symposium of the Society of Chinese Bioscientists in America. 2015. |
| Researcher : Chan CCY |
| Project Title: | Role of Sedlin in the control of endocytosis |
| Investigator(s): | Chan CCY, Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2013 |
| Completion Date: | 03/2015 |
| List of Research Outputs |
| Kudelko M.A., Chan C.C.Y., YAO Q., Cheah K.S.E., Tanner J.A. and Chan D., Hypertrophic Chondrocytes Survive ER Stress by Maintaining Glycolysis and Mitochondrial Membrane Poloarity., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015. |
| Researcher : Chan CP |
| Project Title: | Roles of liver-enriched transcription factor CREB-H in liver fibrosis |
| Investigator(s): | Chan CP, Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2014 |
| Project Title: | Innate Immune Memory; INFLUENZA A VIRUS NS1 PROTEIN TARGETS DOUBLE STRANDED RNA-BINDING PROTEIN PACT TO SUPPRESS INNATE ANTIVIRAL RESPONSE |
| Investigator(s): | Chan CP |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2015 |
| Completion Date: | 03/2015 |
| List of Research Outputs |
| CHENG Y., Tang H.M.V., GAO W., Deng J., Chan C.P. and Jin D., bTrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H, The 15th International Symposium of the Society of Chinese Bioscientists in America. 2015. |
| Chan C.P., YUEN C.K., FUNG S.Y., KEW C., Zheng B., Yuen K.Y. and Jin D., Influenza A virus NS1 protein targets double-stranded RNA binding protein PACT to suppress innate antiviral response, Innate Immune Memory: A Wellcome Trust Scientific Conference. 2015. |
| Jin D., Tang H.M.V., GAO W., Chan C.P. and Yuen K.S., Retroviral oncoprotein Tax-induced activation of LKB1-SIK and SIRT1 signaling in the regulation of HTLV-1 transcription, The 15th International Symposium of the Society of Chinese Bioscientists in America. 2015. |
| Researcher : Chan D |
| Project Title: | Genome-wide identification and functional studies of genetic risk factors for low back pain and intervertebral disc degeneration |
| Investigator(s): | Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | AOSpine International - General Award |
| Start Date: | 08/2007 |
| Project Title: | Research Output Prize (Li Ka Shing Faculty of Medicine) |
| Investigator(s): | Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | Research Output Prize (in Faculty) |
| Start Date: | 12/2010 |
| Project Title: | Interplay between ER stress and hypoxic stress in the regulation of chondrocyte differentiation |
| Investigator(s): | Chan D, Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2012 |
| Project Title: | 9th Pan Pacific Connective Tissue Societies Symposium - The extracellular Matrix niche |
| Investigator(s): | Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | Croucher Foundation - Conference / Seminars |
| Start Date: | 11/2013 |
| Project Title: | Integrative Approaches to Understanding Disorders of the Skeleton |
| Investigator(s): | Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | Croucher Advanced Study Institute |
| Start Date: | 12/2013 |
| Project Title: | Progenitor cells in the formation and repair of articular cartilage |
| Investigator(s): | Chan D, Cheah KSE, Chan BP |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Genetic and cellular basis of protective/regenerative mechanisms in skeletal tissues |
| Investigator(s): | Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | Croucher Senior Research Fellowships in Natural Sciences, Technology and Medicine |
| Start Date: | 08/2014 |
| Project Title: | Mechanisms of energy management in hypertrophic chondrocyte adaptation to ER Stress |
| Investigator(s): | Chan D, Chan BP, Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| List of Research Outputs |
| Chan W.C.W., SHAH A.N., Cheng C.C.W., Cheah K.S.E. and Chan D., Differentiation and migration of endplate chondrocytes contribute to the inner annulus fibrosus in normal and degenerative intervertebral disc., Cartilage Biology & Pathology Gordon Research Conference. Galveston, TX, USA, March 22-27, 2015.. 2015. |
| Cheah K.S.E., Wang C., Tan Z., Tsang K.Y., Ron D., Itoh N. and Chan D., The PERK pathway attenuates ER stress in hypertrophic chondrocytes via SOX9 and FGF21., Cartilage Biology & Pathology Gordon Research Conference. Galveston, TX, USA, March 22-27, 2015.. 2015. |
| Kudelko M.A., Chan C.C.Y., YAO Q., Cheah K.S.E., Tanner J.A. and Chan D., Hypertrophic Chondrocytes Survive ER Stress by Maintaining Glycolysis and Mitochondrial Membrane Poloarity., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015. |
| LAM Y., FENG C., Chan W.C.W., Cheah K.S.E., Chan B.P. and Chan D., Understanding the contribution of Lgr5+ interzone progenitor cells in articular cartilage regeneration., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015. |
| Li Y., Samartzis D., Campbell D., Cherny S.S., Cheung K.M.C., Luk K.D.K., Karppinen J., Song Y., Cheah K.S.E., Sham P.C. and Chan D., A novel pathway associated with lumbar disc degeneration: a genome-wide association study., 42nd International Society for the Study of the Lumbar Spine. San Francisco. June 8-12, 2015.. 2015. |
| Li Y., Kao P., Yip M.S., Sze K.L., Fosang A., McCulloch D., Cheung K.M.C., Samartzis D., Luk K.D.K., Karppinen J., Song Y., Cheah K.S.E., Sham P.C. and Chan D., Association and functional analysis of ADAMTS5 in lumbar disc degeneration, 42nd International Society for the Study of the Lumbar Spine. San Francisco. June 8-12, 2015.. 2015. |
| SHAH A.N., Chan W.C.W. and Chan D., The Role of Hypertrophic Chondrocyte and Cellular Stress in Intervertebral Disc Integrity and Degeneration., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.. 2015. |
| Tam V., Sharma R., Kudelko M.A., Cheah K.S.E., Lam Y.W. and Chan D., Intervertebral disc cell biosynthesis in the degenerate and non-degenerate intervertebral disc., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.. 2015. |
| WEN S., Tan Z., Hui C.C., Chan D. and Cheah K.S.E., Functional roles for Irx3 and Irx5 in the hypertrophic chondrocyte to osteoblast lineage programme, Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.. 2015. |
| Wang X., Cheung M.C.H., Tam P.L.P., Briscoe J. and Chan D., Molecular and Cellular Consequences of Indian Hedgehog Mutations Causing Brachydactylies, Cartilage Biology & Pathology. Gordon Research Conference. Galveston, TX. USA. March 22-27, 2015.. 2015. |
| XIONG C., Li Y., Muhammad, F.R., ., Sandell L., Chan W.C.W., Tam V., ZHANG Y., Song Y. and Cheah K.S.E., Sham P.C., Chan D., Understanding the genetic contribution to endogenous self-protective potentials of intervertebral disc., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.. 2015. |
| YAO Q., Chan W.C.W., Ng V.C.W., Tan Z., Tsang K.Y., Cheah K.S.E. and Chan D., Hypertrophic chondrocytes under ER stress utilizes the hypoxia stress pathway for survival., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.. 2015. |
| YIP K.H.R., Au Y.K., Yang W., Chan D. and Cheah K.S.E., Investigating impact of Sox9 dysfunction in hypertrophic chondrocytes-to-osteoblasts transition., Gordon Research Conference: Cartilage Biology and Pathology TX, USA Mar 22-27, 2015.. 2015. |
| ZHANG Y., Chan W.C.W., Sakai D. and Chan D., Roles of Progenitors cells for Intervertebral Disc Regeneration in “Healer” mice., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.. 2015. |
| Researcher : Chan LK |
| Project Title: | Perception by LKS Faculty of Medicine graduates on their university education |
| Investigator(s): | Chan LK, Ip MSM, Patil NG, Prosser MT |
| Department: | Institute of Med & Health Sci Education |
| Source(s) of Funding: | Teaching Development Grants |
| Start Date: | 06/2008 |
| Project Title: | Identifying the English language and communicative demands of bedside learning on students in the clinical years |
| Investigator(s): | Chan LK, Tse LK, Storey AM |
| Department: | Institute of Med & Health Sci Education |
| Source(s) of Funding: | Medical Faculty Research Grant Fund |
| Start Date: | 06/2008 |
| Project Title: | Assessing competency of dental graduates from problem-based learning and traditional curriculums: Graduates’ and Employers’ Perceptions |
| Investigator(s): | Chan LK, Yiu CKY, Botelho MG, Bridges SM, Corbet EF, Dyson JE, McGrath CPJ, Wong RWK, Prosser MT |
| Department: | Institute of Med & Health Sci Education |
| Source(s) of Funding: | Teaching Development Grants |
| Start Date: | 12/2008 |
| Project Title: | Designing technology-rich environments for case-based instruction: a model for life-long learning |
| Investigator(s): | Chan LK, Lu J |
| Department: | Institute of Med & Health Sci Education |
| Source(s) of Funding: | International Opportunities Fund |
| Start Date: | 03/2010 |
| Project Title: | Development of a fit-for-purpose Chinese-language course for the medical students |
| Investigator(s): | Chan LK, Soo YC, Tse SK |
| Department: | Institute of Med & Health Sci Education |
| Source(s) of Funding: | Faculty Development Fund of Faculty of Medicine |
| Start Date: | 06/2011 |
| Project Title: | The use of mobile devices in problem-based learning |
| Investigator(s): | Chan LK, Bridges SM, Doherty I, Jin J, Ng ML |
| Department: | Institute of Med & Health Sci Education |
| Source(s) of Funding: | Teaching Development Grants |
| Start Date: | 07/2013 |
| List of Research Outputs |
| Bridges S.M., Corbet E.F. and Chan L.K., Designing problem-based curricula: The role of concept mapping in scaffolding learning for the health sciences, Knowledge Management & E-Learning . 2015, 7(1): 119-133. |
| Chan L.K., Yang J. and Irby D., Application of the One-Minute Preceptor Technique by Novice Teachers in the Gross Anatomy Laboratory, Anatomical Sciences Education. 2015. |
| Chan L.K., Yang J. and Irby D.M., Application of the one-minute preceptor technique by novice teachers in the gross anatomy laboratory, Anatomical Sciences Education. 2015, n/a-n/a. |
| Chan L.K., Chen J.Y. and Chung W.S.E., In: Chan LK, Chen JY, Chung EWS , Dissecting the Meaning of Life – An Anthology of Essays on Body Donation . 大體大得——遺體捐贈 感思文集, Hong Kong, Wheatear, 2015. |
| Chan L.K. and Uhlmann M., Elements of successful adult learning, In: Chan LK, Pawlina W , Teaching Anatomy – A Practical Guide. Cham, Springer, 2015, 3-10. |
| Chan L.K., Giving a lecture, In: Chan LK, Pawlina W , Teaching Anatomy – A Practical Guide. Cham, Springer, 2015, 61-72. |
| Chan L.K., Promoting reflection in the laboratory, In: Chan LK, Pawlina W , Teaching Anatomy – A Practical Guide. Cham, Springer, 2015, 203-212. |
| Chan L.K. and Pawlina W., In: Chan LK, Pawlina W , Teaching Anatomy – A Practical Guide. Cham, Springer, 2015. |
| Chan L.K., The Hand of the Teacher , 老師的手, In: Chan LK, JY Chen, EWS Chung , Dissecting the Meaning of Life – An Anthology of Essays on Body Donation . 大體大得——遺體捐贈 感思文集, Hong Kong, Wheatear, 2015. |
| Chan L.K., The use of low-tech models to enhance the learning of anatomy, In: Chan LK, Pawlina W , Teaching Anatomy – A Practical Guide. Cham, Springer, 2015, 259-266. |
| Researcher : Chan WCW |
| Project Title: | Understanding the Differentiation of Inner Annulus Fibrosus Cells: An in vitro Approach |
| Investigator(s): | Chan WCW, Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Chan W.C.W., SHAH A.N., Cheng C.C.W., Cheah K.S.E. and Chan D., Differentiation and migration of endplate chondrocytes contribute to the inner annulus fibrosus in normal and degenerative intervertebral disc., Cartilage Biology & Pathology Gordon Research Conference. Galveston, TX, USA, March 22-27, 2015.. 2015. |
| LAM Y., FENG C., Chan W.C.W., Cheah K.S.E., Chan B.P. and Chan D., Understanding the contribution of Lgr5+ interzone progenitor cells in articular cartilage regeneration., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015. |
| SHAH A.N., Chan W.C.W. and Chan D., The Role of Hypertrophic Chondrocyte and Cellular Stress in Intervertebral Disc Integrity and Degeneration., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.. 2015. |
| XIONG C., Li Y., Muhammad, F.R., ., Sandell L., Chan W.C.W., Tam V., ZHANG Y., Song Y. and Cheah K.S.E., Sham P.C., Chan D., Understanding the genetic contribution to endogenous self-protective potentials of intervertebral disc., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.. 2015. |
| YAO Q., Chan W.C.W., Ng V.C.W., Tan Z., Tsang K.Y., Cheah K.S.E. and Chan D., Hypertrophic chondrocytes under ER stress utilizes the hypoxia stress pathway for survival., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.. 2015. |
| ZHANG Y., Chan W.C.W., Sakai D. and Chan D., Roles of Progenitors cells for Intervertebral Disc Regeneration in “Healer” mice., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.. 2015. |
| Researcher : Chan YS |
| Project Title: | 30th Annual Conference of Society for Neuroscience Expression of N-Methyl-D-Aspartate Receptor Subunits and Induction of c-fos in Otolith Neurons in the Vestibular Nuclei of Postnatal Rats |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2000 |
| Project Title: | 31st Annual Meeting of Society for Neuroscience Expression of Neurotrophin Receptors in Vestibular Nuclei During the Postnatal Development of the Rat |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2001 |
| Project Title: | XXIV Annual Conference of Indian Academy of Neurosciences Development Refinement of Spatial Recognition Circuits |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 12/2006 |
| Project Title: | Role of the thalamus in integrating spatial information and guiding navigation |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2009 |
| Project Title: | Outstanding Research Student Supervisor Award 2009-10 |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | Outstanding Research Student Supervisor Award |
| Start Date: | 12/2010 |
| Project Title: | Vestibular nuclear signals regulate the postnatal development of a thalamic network for spatial navigation |
| Investigator(s): | Chan YS, Shum DKY |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2011 |
| Project Title: | Long-term depression of inhibitory responses is critical to the maturation of the vestibular circuitry |
| Investigator(s): | Chan YS, Shum DKY |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2012 |
| Project Title: | Serotonin-induced bidirectional modulation of activity-dependent synaptic plasticity tunes vestibular functions |
| Investigator(s): | Chan YS, Shum DKY |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2013 |
| Project Title: | Neuroscience 2014; Glutamergic transmission in the vestibular nucleus is critical to the formation of spatial topography and acquisition of spatial navigation in rats |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2014 |
| Completion Date: | 11/2014 |
| Project Title: | Orexin-induced modulation of activity-dependent synaptic plasticity is critical for the maturation of vestibular circuitry and functions |
| Investigator(s): | Chan YS, Shum DKY, Lai CH |
| Department: | Physiology |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2015 |
| List of Research Outputs |
| Chan Y.S., European Journal of Neuroscience (Associate Editor), Wiley (USA), 2015. |
| Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilization of Chondroitinase ABC-I and -II on Chitosan Microbeads Improve Neurite Growth in CSPG-Enriched Astrocyte Culture, 10th International Symposium on Healthy Aging: A Decade of Positive Aging. 2015. |
| Tai W.Y.E., Shea G.K.H., Leung H.Y., Tsui Y.P., Chan Y.S. and Shum D.K.Y., INSTRUCTIVE ROLE OF DRG NEURONS IN DERIVATION OF SCHWANN CELLS FROM BONE MARROW STROMAL CELLS, Tenth International Symposium on Healthy Aging “A Decade of Positive Aging”. 2015. |
| Tam K.W., Chan Y.S. and Shum D.K.Y., Stability and Kinetics of Chondroitinase ABC in Macromolecular Crowded Environment, 10th International Symposium on Healthy Aging: A Decade of Positive Aging. 2015. |
| Tsui Y.P., Shum D.K.Y. and Chan Y.S., Towards remyelination: derivation of oligodendrocyte precursors and Schwann cells from neural progenitors harbored by adult bone marrow stromal cells, Cold Spring harbor Asia Conference: Novel Insights into Glia Function & Dysfunction. 2015. |
| Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Nerve Conduit Constructed by Aligned Chitosan Nanofibers for Directing Axonal Growth in Nerve Regeneration, 10th International Symposium on Healthy Aging: A Decad of Positive Aging. 2015. |
| Researcher : Chang RCC |
| Project Title: | Significance of molecular signaling for protein translation control in neurodegeneration of amyotrophic lateral sclerosis |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Liu Po Shan/Dr Vincent Liu Endowment Fund for Motor Neuron diseases - General Award |
| Start Date: | 03/2008 |
| Project Title: | Investigating tau degradation: the underlying mechanisms for the pathogenesis of Alzheimer’s disease |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2014 |
| Completion Date: | 04/2015 |
| Project Title: | Society for Neuroscience 2014; Investigating the effects of anesthetic dexmedetomidine on tau phosphorylation |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2014 |
| Completion Date: | 11/2014 |
| Project Title: | Elucidating pathological mechanisms of visual impairment in the pathogenesis of Alzheimer’s disease: from basic science to innovative approach of disease monitoring (CRF) |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding for Incubating Group-based Collaborative Research Projects |
| Start Date: | 01/2015 |
| Project Title: | Elucidating the molecular defects associated with PTEN mutations in Autism Spectrum Disorders |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 04/2015 |
| Project Title: | Advancement for developing drug against Lewy Body Dementia by establishing a pre-clinical experimental model |
| Investigator(s): | Chang RCC, Ho YS, Ng TW, Chu MT |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 04/2015 |
| Project Title: | Investigating molecular mechanisms underlying escitalopram as neuroprotectant & antidepressant in AD mice |
| Investigator(s): | Chang RCC, Ho YS, Ng TW, Hung CHL |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2015 |
| Project Title: | Investigating oxyresveratrol as potential neuroprotective drug in experimental models of Parkinson’s disease |
| Investigator(s): | Chang RCC, Ng KM, Wang M, Ho YS |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2015 |
| Project Title: | Investigation of drugs targeting mitochondrial dynamics and reactive oxygen species for Parkinson’s disease treatment using in vitro and in vivo imaging models |
| Investigator(s): | Chang RCC, Hung CHL |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Chang R.C.C., Editorial Board Member, Journal of Alzheimer's Disease, Dementia & Parkinsonism. 2015. |
| Researcher : Cheah KSE |
| Project Title: | Defining the role of the transcription factor Sox9 in skeletal development by tissue-specific gene inactivation |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | UK/Hong Kong Joint Research Scheme |
| Start Date: | 02/1998 |
| Project Title: | 4th Pan-Pacific Connective Tissues Societies Symposium Abnormal Regulation of Cartilage and Bone Growth in Transgenic Mice Expressing a Collagen X SMCD Mution |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/1999 |
| Project Title: | Human Genome Meeting 2001 Genomic Analysis of the Mutant Locus in the Novel Transgenic Mouse Mutant, Yellow Submarine (ysb) |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2001 |
| Project Title: | 67th Cold Spring Harbor Symposium on Quantitative Biology - The Cardiovascular System An Essential Role for Type IIA Procollagen in Heart Development |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2002 |
| Project Title: | 1st Annual Meeting of the American Society for Matrix Biology Type IIA Procollagen is Essential for Proper Heart Development |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2002 |
| Project Title: | The Gordon Research Conference on Cartilage Biology and Pathology Chondrocytes Survive ER Stress Caused by Unfolded Proteins and Differentiation is Re-programmed |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2005 |
| Project Title: | 11th Human Genome Meeting Procollagen IIA Facilitates BMP Signaling in Heart Development |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2006 |
| Project Title: | Cold Spring Harbor Laboratory Meeting on Mouse Molecular Genetics Insight into the Molecular Pathogenesis of Campomelic Dysplasia Received By A Conditional SOX9 Mutant Mouse Model |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2006 |
| Project Title: | Role of Sox2 in the stemness of dermal precursors |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2010 |
| Project Title: | Genetic analyses of sensory fate determination in inner ear development |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2010 |
| Completion Date: | 08/2014 |
| Project Title: | Hong Kong Society for Developmental Biology Symposium - from Embryology to Disease Mechanisms |
| Investigator(s): | Cheah KSE, Lui VCH |
| Department: | Biochemistry |
| Source(s) of Funding: | Croucher Foundation - Conference / Seminars |
| Start Date: | 11/2012 |
| Project Title: | Functional analyses of how genomic variation affects personal risk for degenerative skeletal disorders |
| Investigator(s): | Cheah KSE, Chan BP, Chan D, Cheung KMC, Jin D, Lian Q, Luk KDK, Sham PC, Zhang MQ, Cherny SS, Huang J, Ng RK, Samartzis D, Song Y, Wang JJ |
| Department: | Biochemistry |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 01/2013 |
| Project Title: | Genetic analyses of the roles of Sox2 and Sox18 in hair follicle development |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Project Title: | Stem cells: Niches, Regeneration & Repair |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | Croucher Advanced Study Institute |
| Start Date: | 03/2013 |
| Project Title: | Development and Reproduction |
| Investigator(s): | Cheah KSE, Ng EHY, Wu EX |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 06/2013 |
| Project Title: | Identifying critical transitions and gene regulatory networks controlling phases of chondrocyte differentiation in the growth plate |
| Investigator(s): | Cheah KSE, Wang JJ, Chan D, Ng RK |
| Department: | Biochemistry |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2014 |
| Project Title: | Mechanistic insights into the genesis and physiological role of hypertrophic chondrocyte-derived osteoblasts |
| Investigator(s): | Cheah KSE, Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Craniofacial Morphogenesis & Tissue Regeneration; Transcriptional control of sensory progenitor specification in the inner ear |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2014 |
| Project Title: | Mechanisms controlling determination of sensory versus non-sensory fate in inner ear development |
| Investigator(s): | Cheah KSE, Wong YME, Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2014 |
| Project Title: | Global Spine Congress 2015; The changing RNAome of the developing nucleus pulposus of the intervertebral disc - implications for Intervertebral Disc Disease |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2015 |
| List of Research Outputs |
| Au Y.K., Wynn S., Szeto Y.Y., Geng Y.H., Tan T.Y., Cheung K.M.C. and Cheah K.S.E., Understanding the Molecular Impact of Sox9 Y440X in Campomelic Dysplasia., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015. |
| Chan W.C.W., SHAH A.N., Cheng C.C.W., Cheah K.S.E. and Chan D., Differentiation and migration of endplate chondrocytes contribute to the inner annulus fibrosus in normal and degenerative intervertebral disc., Cartilage Biology & Pathology Gordon Research Conference. Galveston, TX, USA, March 22-27, 2015.. 2015. |
| Cheah K.S.E., Au Y.K., Wynn S., Tan T.Y. and YIP K.H.R., Sox9 restrains chondrocyte to osteoblast lineage progression-implications for the pathogenesis of Campomelic Dysplasia., International Society for Stem Cell Research, ISSCR 2015 Annual Meeting. Stockholm, Sweden. 24-27 June 2015.. 2015. |
| Cheah K.S.E., Wang C., Tan Z., Tsang K.Y., Ron D., Itoh N. and Chan D., The PERK pathway attenuates ER stress in hypertrophic chondrocytes via SOX9 and FGF21., Cartilage Biology & Pathology Gordon Research Conference. Galveston, TX, USA, March 22-27, 2015.. 2015. |
| Kudelko M.A., Chan C.C.Y., YAO Q., Cheah K.S.E., Tanner J.A. and Chan D., Hypertrophic Chondrocytes Survive ER Stress by Maintaining Glycolysis and Mitochondrial Membrane Poloarity., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015. |
| LAM Y., FENG C., Chan W.C.W., Cheah K.S.E., Chan B.P. and Chan D., Understanding the contribution of Lgr5+ interzone progenitor cells in articular cartilage regeneration., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015. |
| Li Y., Samartzis D., Campbell D., Cherny S.S., Cheung K.M.C., Luk K.D.K., Karppinen J., Song Y., Cheah K.S.E., Sham P.C. and Chan D., A novel pathway associated with lumbar disc degeneration: a genome-wide association study., 42nd International Society for the Study of the Lumbar Spine. San Francisco. June 8-12, 2015.. 2015. |
| Li Y., Kao P., Yip M.S., Sze K.L., Fosang A., McCulloch D., Cheung K.M.C., Samartzis D., Luk K.D.K., Karppinen J., Song Y., Cheah K.S.E., Sham P.C. and Chan D., Association and functional analysis of ADAMTS5 in lumbar disc degeneration, 42nd International Society for the Study of the Lumbar Spine. San Francisco. June 8-12, 2015.. 2015. |
| Szeto Y.Y., Au Y.K., Wu M.H., Dung W.F. and Cheah K.S.E., The role of Zic3 and BAF complex in notochord cell lineage progression, Gordon Research Conference: Genome Architecture in Cell Fate & Disease Hong Kong, Jun 7-12, 2015.. 2015. |
| Tam V., Sharma R., Kudelko M.A., Cheah K.S.E., Lam Y.W. and Chan D., Intervertebral disc cell biosynthesis in the degenerate and non-degenerate intervertebral disc., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.. 2015. |
| WEN S., Tan Z., Hui C.C., Chan D. and Cheah K.S.E., Functional roles for Irx3 and Irx5 in the hypertrophic chondrocyte to osteoblast lineage programme, Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.. 2015. |
| XIONG C., Li Y., Muhammad, F.R., ., Sandell L., Chan W.C.W., Tam V., ZHANG Y., Song Y. and Cheah K.S.E., Sham P.C., Chan D., Understanding the genetic contribution to endogenous self-protective potentials of intervertebral disc., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.. 2015. |
| YAO Q., Chan W.C.W., Ng V.C.W., Tan Z., Tsang K.Y., Cheah K.S.E. and Chan D., Hypertrophic chondrocytes under ER stress utilizes the hypoxia stress pathway for survival., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.. 2015. |
| YIP K.H.R., Au Y.K., Yang W., Chan D. and Cheah K.S.E., Investigating impact of Sox9 dysfunction in hypertrophic chondrocytes-to-osteoblasts transition., Gordon Research Conference: Cartilage Biology and Pathology TX, USA Mar 22-27, 2015.. 2015. |
| YIP K.H.R., Tan T.Y., Cheung M.C.H. and Cheah K.S.E., Long-range regulation of Sox9 in development and disease., Gordon Research Conference: Genomic Architecture in Cell Fate & Disease Hong Kong Jun 7-12, 2015.. 2015. |
| Researcher : Chen J |
| Project Title: | Effects of Influenza A (H1N1) Virus Infection on Ion Transport of Pig Tracheal Epithelia |
| Investigator(s): | Chen J, Chen H, Li GR |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2013 |
| Project Title: | CFTR Activation by Regional Phosphorylation on the R Domain |
| Investigator(s): | Chen J |
| Department: | Physiology |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 09/2013 |
| Project Title: | Investigating the molecular mechanisms how ΔF508 mutation delays phosphorylation-dependent CFTR activation |
| Investigator(s): | Chen J |
| Department: | Physiology |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2014 |
| Project Title: | Molecular mechanisms of bicarbonate transport and impaired pH sensitivity in ΔF508-CFTR |
| Investigator(s): | Chen J |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2015 |
| Project Title: | The 5th International Ion Channel Conference (IICC-5): Structure, Function Regulation & Therapeutics; Deletions of the Y512 and F508 residues in the cystic fibrosis transmembrane conductance regulator may cause similar structural defects affecting protein processing |
| Investigator(s): | Chen J |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Chen J., The regulatory domain-mediated regional activation of the cystic fibrosis transmembrane conductance regulator, The 9th Asian Biophysics Association (ABA) Symposium, Shangyu City, China. 2015. |
| Researcher : Chen P |
| Project Title: | 2015 International Workshop on Statistical Genetic Methods for Human Complex Traits; A Bayesian framework for characterizing and prioritizing GWAS risk loci of psychiatric disorders using tissue-specific eQTLs and co-expression networks |
| Investigator(s): | Chen P |
| Department: | Psychiatry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2015 |
| List of Research Outputs |
| Chen P., The Lindon Eaves Award for Best Student Poster Presented on a Wednesday, In: Benjamin Neale, Dave Evans, and John Hewitt, The 2015 International Workshop on Statistical Genetic Methods for Human Complex Traits. 2015. |
| Researcher : Cheng CCW |
| List of Research Outputs |
| Chan W.C.W., SHAH A.N., Cheng C.C.W., Cheah K.S.E. and Chan D., Differentiation and migration of endplate chondrocytes contribute to the inner annulus fibrosus in normal and degenerative intervertebral disc., Cartilage Biology & Pathology Gordon Research Conference. Galveston, TX, USA, March 22-27, 2015.. 2015. |
| Researcher : Cheung A |
| Project Title: | Id1-induced IGF2 promotes esophageal cancer progression through instigation of stromal fibroblasts and bone marrow-derived vascular progenitor cells |
| Investigator(s): | Cheung A, Chan KW, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2012 |
| Project Title: | MicroRNA-377 inhibits growth and metastasis of esophageal cancer stem-like cells by directly repressing CD133 – mechanisms and implications for cancer stem cell-targeted therapy |
| Investigator(s): | Cheung A, Chan KW, Law SYK, Tsao GSW, Li B |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2013 |
| Project Title: | FBXO31 regulates stress-induced cell apoptosis by mediating K48-linked ubiquitination and degradation of phosphorylated MKK6 |
| Investigator(s): | Cheung A |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 04/2014 |
| Completion Date: | 03/2015 |
| Project Title: | 23rd Biennial Congress of the European Association for Cancer Research ; Role of Id1-IGF2-VEGF-VEGFR relay in esophageal tumorigenesis |
| Investigator(s): | Cheung A |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2014 |
| Completion Date: | 07/2014 |
| Project Title: | Roles and mechanisms of E2F1 and IGF2 in regulating chemosensitivity of esophageal cancer |
| Investigator(s): | Cheung A, Li B |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2014 |
| Project Title: | Identification of miR-29c/FBXO31 as a key regulatory mechanism in esophageal cancer chemoresistance-functional validation and implication for therapy |
| Investigator(s): | Cheung A, Li B |
| Department: | Anatomy |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2015 |
| Project Title: | Role of miR-338-5p as a novel modulator of chemoresistance in esophageal cancer |
| Investigator(s): | Cheung A, Chan KW, Law SYK, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| List of Research Outputs |
| HAN L., Li B., Tsao G.S.W. and Cheung A., Roles of miR-338-5p in downregulating Id1 and inhibiting chemoresistance, Non-Coding RNAS 2015, International Conference "The long and the short of non- Coding RNAs", Chania, Greece, June 14-19, 2015. |
| Researcher : Cheung MCH |
| Project Title: | In vivo Functional Analysis of Posttranslational Modifications of Sox9 in Neural Crest Development |
| Investigator(s): | Cheung MCH, Zhou G |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2010 |
| Project Title: | Investigating the roles of SOX9 in human neural stem cells |
| Investigator(s): | Cheung MCH |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | 2014 International SOX Research Conference; Sox9 and the molecular network regulating neural crest cell motility |
| Investigator(s): | Cheung MCH |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2014 |
| Completion Date: | 09/2014 |
| Project Title: | In vivo functional characterization of a Rho GTPase-activating protein, DLC1, in neural crest development |
| Investigator(s): | Cheung MCH |
| Department: | Anatomy |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 10/2014 |
| Project Title: | Single-cell transcriptomics in Sertoli cells and neural crest cells |
| Investigator(s): | Cheung MCH |
| Department: | Anatomy |
| Source(s) of Funding: | SFC / RGC Joint Research Scheme |
| Start Date: | 01/2015 |
| Project Title: | Elucidating the contribution of cross-regulatory interactions between SOX9 and SOX10 to melanoma progression |
| Investigator(s): | Cheung MCH, Lung HL |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2015 |
| List of Research Outputs |
| LI T., ZHENG F., Cheung M.C.H., Wang F.S. and Fu C., Fission yeast mitochondria are distributed by dynamic microtubules in a motor-independent manner, Scientific Reports. Nature Publishing Group, 2015, 5: 1-10. |
| Wang X., Cheung M.C.H., Tam P.L.P., Briscoe J. and Chan D., Molecular and Cellular Consequences of Indian Hedgehog Mutations Causing Brachydactylies, Cartilage Biology & Pathology. Gordon Research Conference. Galveston, TX. USA. March 22-27, 2015.. 2015. |
| YIP K.H.R., Tan T.Y., Cheung M.C.H. and Cheah K.S.E., Long-range regulation of Sox9 in development and disease., Gordon Research Conference: Genomic Architecture in Cell Fate & Disease Hong Kong Jun 7-12, 2015.. 2015. |
| Researcher : Cheung YW |
| List of Research Outputs |
| DIRKZWAGER R.M., Cheung Y.W., Richards J.S. and Tanner J.A., . New technologies for old diseases: the potential of DNA aptamers in point-of-care malaria diagnosis., . Hong Kong Inter-University Postgraduate Symposium on Life Science 2015, Hong Kong. 2015. |
| Researcher : Ching YP |
| Project Title: | Roles of p21-activated protein kinase (Pak) 1 in the pathogenesis of liver cancer |
| Investigator(s): | Ching YP, Ng IOL, Jin D, Yau TO |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2006 |
| Project Title: | Hepatitis B virus promotes hepatocarcinogenesis by activation of Pak1 |
| Investigator(s): | Ching YP, Jin D |
| Department: | Anatomy |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2010 |
| Completion Date: | 08/2014 |
| Project Title: | HBx oncoprotein induces chromosome instability in hepatocarcinogenesis via dysregulation of centrosome duplication regulatory protein, TAX1BP2 |
| Investigator(s): | Ching YP, Jin D |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2013 |
| Project Title: | The role of centrosomal kinase Nek2 in the pathogenesis of liver cancer |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2013 |
| Completion Date: | 04/2015 |
| Project Title: | Functional characterization of the roles of NIMA-related kinase, Nek2 in liver cancer development and metastasis |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Functional characterization of the roles of NIMA-related kinase, Nek2 in liver cancer development and metastasis |
| Investigator(s): | Ching YP, Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | The therapeutic potential of Polo-like protein kinase 4 in liver cancer |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2015 |
| Project Title: | WIN 2015 Symposium, Novel Targets, Innovative agents, advanced technologies: A Winnning Strategy; The centrosomal protein, TAX1 binding protein 2 (TAX1BP2) regulates the chemo-sensitivity of liver cancer cells |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Ching Y.P. and Lai W.L., The centrosomal protein, TAX1 binding protein 2 (TAX1BP2) regulates the chemo-sensitivity of liver cancer cells, WIN 2015 Symposium. 2015, Abstract code: P6.04. |
| Kung C.Y. and Ching Y.P., The role of Salt-inducible kinase 2 in hepatocellular carcinoma, In: EMBL, EMBO Symposia - Frontiers in Stem Cells and Cancer. Heidelberg, Germany, 2015. |
| Tang H.C., Li S.K. and Ching Y.P., HBx deregulates centrosome integrity and induces genomic instability in Hepatocellular Carcinoma, In: Keystone Symposia , Keystone Conference - Viruses and Human Cancer. Montana, USA, 2015. |
| Researcher : Chung SK |
| Project Title: | Stem Cell Strategy for Nervous System Disorders |
| Investigator(s): | Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 09/2012 |
| Project Title: | Molecular Basis for Diabetes-induced Painless and Painful Neuropathy, and Inability to Structurally and Functionally Recovery after Peripheral Nerve Injury |
| Investigator(s): | Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2012 |
| Project Title: | To Determine the Role of Exchange Protein Directly Activated by cAMP, Epac 1 and Epac2, in the Blood-retinal Barrier and Neuroinflammation in Retina |
| Investigator(s): | Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Aldose Reductase(AR) effect dopaminergic neuronal autophagy through microglia after acute inflammation in Parkinson’s disease |
| Investigator(s): | Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Hung K.L., Yeung P.K.K., Lai K.W., Lo A.C.Y., Chan C.K., Wu E.X., Chung S.M. and Chung S.K., Selective astrocytic endothelin-1 overexpression contributes to dementia associated with ischemic stroke by exaggerating astrocyte-derived amyloid secretion, In: Victor KL Hung1, Patrick KK Yeung1,2, Angela KW Lai1, Maggie CY Ho1, Amy CY Lo1,8, Kevin C Chan3,9, Ed XK Wu3, Stephen SM Chung4,10, Chi W Cheung5,6 and Sookja K Chung1,2,6,7, Journal of Cerebral Blood Flow & Metabolism. 2015. |
| LIU J., Yeung P.K.K., Cheng L., Lo A.C.Y., Chung S.M. and Chung S.K., Epac2-deficiency leads to more severe retinal swelling, glial reactivity and oxidative stress in transient middle cerebral artery occlusion induced ischemic retinopathy, In: LIU Jin, YEUNG Patrick Ka Kit, CHENG Lu, LO Amy Cheuk Yin,CHUNG Stephen Sum Man & CHUNG Sookja Kim, Science China Life Sciences. 2015. |
| Researcher : Chung WSE |
| List of Research Outputs |
| Chan L.K., Chen J.Y. and Chung W.S.E., In: Chan LK, Chen JY, Chung EWS , Dissecting the Meaning of Life – An Anthology of Essays on Body Donation . 大體大得——遺體捐贈 感思文集, Hong Kong, Wheatear, 2015. |
| Researcher : DIRKZWAGER RM |
| List of Research Outputs |
| DIRKZWAGER R.M., Cheung Y.W., Richards J.S. and Tanner J.A., . New technologies for old diseases: the potential of DNA aptamers in point-of-care malaria diagnosis., . Hong Kong Inter-University Postgraduate Symposium on Life Science 2015, Hong Kong. 2015. |
| DIRKZWAGER R.M., Richard J.S. and Tanner J.A., A novel aptamer-based colorimetric test for malaria., 4th International Conference on Bio-Sensing Technology, Lisbon, Portugal (2015). 2015. |
| DIRKZWAGER R.M., Cheung Y.W., Richards J.S. and Tanner J.A., Diagnosing malaria using DNA aptamers against P. falciparum LDH., Point of Care Diagnostics World Congress, San Diego, USA (2014). 2014. |
| TANG S.L.M., Godonoga M., DIRKZWAGER R.M., KINGHORN A.B. and Heddle J.G., Aptamer-functionalized DNA origami: an emerging tool for malaria diagnosis., Hong Kong Inter-University Postgraduate Symposium on Life Science 2015, Hong Kong. 2015. |
| TANG S.L.M., Godonoga M., DIRKZWAGER R.M., KINGHORN A.B., Heddle J.G. and Tanner J.A., Best poster presentation prize, HKU 19th Research Postgraduate Symposium, Hong Kong 2014. 2014. |
| Researcher : Deng J |
| List of Research Outputs |
| CHENG Y., Tang H.M.V., GAO W., Deng J., Chan C.P. and Jin D., bTrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H, The 15th International Symposium of the Society of Chinese Bioscientists in America. 2015. |
| Deng J., Best Poster Presentation Award: Activation of hepatitis B virus transcription by PRMT5 protein arginine methyltransferases, The 15th International Symposium of the Society of Chinese Bioscientists in America. 2015. |
| Researcher : Dung WF |
| List of Research Outputs |
| Szeto Y.Y., Au Y.K., Wu M.H., Dung W.F. and Cheah K.S.E., The role of Zic3 and BAF complex in notochord cell lineage progression, Gordon Research Conference: Genome Architecture in Cell Fate & Disease Hong Kong, Jun 7-12, 2015.. 2015. |
| Researcher : FRASER LA |
| List of Research Outputs |
| FRASER L.A., TANG Y.H., KINGHORN A.B., Shum H.C. and Tanner J.A., Enriching catalytic DNA., Hong Kong Inter-University Postgraduate Symposium on Life Science 2015, Hong Kong. 2015. |
| Researcher : FUNG SY |
| List of Research Outputs |
| Chan C.P., YUEN C.K., FUNG S.Y., KEW C., Zheng B., Yuen K.Y. and Jin D., Influenza A virus NS1 protein targets double-stranded RNA binding protein PACT to suppress innate antiviral response, Innate Immune Memory: A Wellcome Trust Scientific Conference. 2015. |
| Chan C.P., Lui P.Y., FUNG S.Y. and Kok K.H., PACT targeting is a novel viral strategy of innate immune evasion, The 9th Chinese Society for Immunology Symposium. 2014. |
| Researcher : Fu C |
| Project Title: | Systematic investigation of the roles of mitotic kinesins in spindle dynamics |
| Investigator(s): | Fu C |
| Department: | Biochemistry |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2013 |
| Project Title: | Roles of a novel spindle pole body protein psr1p in bipolar spindle assembly and kinetochore clustering |
| Investigator(s): | Fu C |
| Department: | Biochemistry |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 12/2013 |
| Project Title: | The role of kinesin-8 in anaphase B spindle elongation |
| Investigator(s): | Fu C |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2014 |
| Completion Date: | 05/2015 |
| Project Title: | The 2014 American Society for Cell Biology (ASCB)/International Federation for Cell Biology (IFCB) Meeting; Csi1p recruits alp7p/TACC to the spindle pole bodies for bipolar spindle formation |
| Investigator(s): | Fu C |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 12/2014 |
| Completion Date: | 12/2014 |
| Project Title: | The role of Cdk1 mediated phosphorylation of the CENP-A chaperone Scm3p in mitosis |
| Investigator(s): | Fu C |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2015 |
| List of Research Outputs |
| LI T., ZHENG F., Cheung M.C.H., Wang F.S. and Fu C., Fission yeast mitochondria are distributed by dynamic microtubules in a motor-independent manner, Scientific Reports. Nature Publishing Group, 2015, 5: 1-10. |
| Researcher : GAO W |
| List of Research Outputs |
| CHENG Y., Tang H.M.V., GAO W., Deng J., Chan C.P. and Jin D., bTrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H, The 15th International Symposium of the Society of Chinese Bioscientists in America. 2015. |
| GAO W., Best Poster Presentation Award: Ubiquitination and degradation of CRTC1 transcriptional coactivator triggered by salt-inducible kinase 1-dependent phosphorylation, The 15th International Symposium of the Society of Chinese Bioscientists in America. 2015. |
| Jin D., Tang H.M.V., GAO W., Chan C.P. and Yuen K.S., Retroviral oncoprotein Tax-induced activation of LKB1-SIK and SIRT1 signaling in the regulation of HTLV-1 transcription, The 15th International Symposium of the Society of Chinese Bioscientists in America. 2015. |
| Researcher : HAN L |
| List of Research Outputs |
| HAN L., Li B., Tsao G.S.W. and Cheung A., Roles of miR-338-5p in downregulating Id1 and inhibiting chemoresistance, Non-Coding RNAS 2015, International Conference "The long and the short of non- Coding RNAs", Chania, Greece, June 14-19, 2015. |
| Researcher : Hao Q |
| Project Title: | Engineering CD38 for Calcium Signaling |
| Investigator(s): | Hao Q |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2011 |
| Completion Date: | 09/2014 |
| Project Title: | Structure and Function of the TRPM2 channel |
| Investigator(s): | Hao Q, Kotaka M, Lee HC |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2012 |
| Project Title: | Structural Biology of Human PECAM-1 (CD31) in Cell Adhesion and Leukocyte Transmigration |
| Investigator(s): | Hao Q, Zhang H |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2012 |
| Project Title: | Investigation of pathogenesis mechanism of two infectious fungi Penicillium marneffei and Aspergillus fumigatus |
| Investigator(s): | Hao Q |
| Department: | Physiology |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2014 |
| Project Title: | Asia Oceania Forum for Synchrotron Radiation Research; Novel Structure and function of human sirtuins |
| Investigator(s): | Hao Q |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2014 |
| Completion Date: | 09/2014 |
| Project Title: | Novel Structure and Function of Human Sirtuins |
| Investigator(s): | Hao Q, Huang J, Li X |
| Department: | Physiology |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 03/2015 |
| Project Title: | Structure and Function of Human SIRT4 |
| Investigator(s): | Hao Q |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2015 |
| List of Research Outputs |
| Hao Q., Novel Structure and Function of Human Sirtuins, Asia Biophysics Association (ABA2015) meeting. 2015. |
| Researcher : Huang J |
| Project Title: | RNA-DNA hybrid oligonucleotide mediated site-specific repair and gene therapy |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Matching Fund for Hi-Tech Research and Development Program of China (863 Projects) |
| Start Date: | 01/2003 |
| Project Title: | Development of a Pan-organism Riboregulator Device |
| Investigator(s): | Huang J, Jin Y |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Support Programme (Tier 3) |
| Start Date: | 11/2009 |
| Project Title: | Development of a Pan-organism Riboregulator Device |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 12/2009 |
| Project Title: | Role of kinesin-1 in NMDAR trafficking and cerebral ischemia |
| Investigator(s): | Huang J, Lin R |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2012 |
| Project Title: | Guiding the immune response: a novel approach for HIV-1 vaccine development |
| Investigator(s): | Huang J, Zhang M |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Project Title: | Outstanding Research Student Supervisor Award 2011-12 |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Outstanding Research Student Supervisor Award |
| Start Date: | 01/2013 |
| Project Title: | Protein Trafficking: Mechanism and Diseases |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 04/2013 |
| Project Title: | Non-canonical role of Kif5b in clathrin uncoating and the endocytic regulation of muscarinic acetylcholine receptors |
| Investigator(s): | Huang J, Ni Y |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2013 |
| Project Title: | A Generic Mechanism for Pattern Formation: From Theoretical Physics To Synthetic Biology |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | France/Hong Kong Joint Research Scheme - Travel Grants |
| Start Date: | 01/2014 |
| Project Title: | Regulation of epithelial cell proliferation by mechanical force |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | 18th European Bioenergetics Conference; Molecular Motor Protein Kinesin-1 Controls The Localization Of Mitochondria And Myofibrils Components |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2014 |
| Completion Date: | 07/2014 |
| Project Title: | In vivo delivery and expression of shRNA targeting SKI and SI9 by Salmonella to tumours |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | SFC / RGC Joint Research Scheme |
| Start Date: | 01/2015 |
| Project Title: | Pattern formation by bacteria: from theoretical physics to synthetic biology |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | ANR / RGC Joint Research Scheme |
| Start Date: | 01/2015 |
| Project Title: | A feasibility study on the inhibition of Staphylococcus aureus infection using AdsA specific antibodies |
| Investigator(s): | Huang J, Chen Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| Project Title: | Biochemical and biophysical characterization of Kif5b cargo binding domain |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2015 |
| Project Title: | Development of antibodies against Staphylococcus aureus infection |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Cui J., Li X.L., Duan Z.Q., XUE W., Wong Z., Lu S., Lin R.Z., Liu M.F., Zhu G.X., Huang J. and Long D., Analysis of Kif5b Expression during Mouse Kidney Development, PLOS ONE. 2015, 10: e0126002. |
| Huang J., Zheng B. and Yuen K.Y., Live recombinant Salmonella oral vaccine against avian influenza viruses, Hong Kong Medical Journal. 2015, V21(3): 14-16. |
| Zhang B., HUA Y., Yu B., Lau C.Y., Cai J., Zheng S.Y., Yam W.C., Kao R.Y.T., Sze K.H., Zheng B., Yuen K.Y. and Huang J., Recombinant ESAT-6-Like Proteins Provoke Protective Immune Responses against Invasive Staphylococcus aureus Disease in a Murine Model, Infection and Immunity. 2015, 83: 339-345. |
| Researcher : Huen MSY |
| Project Title: | Molecular and functional characterisation of USP34, a ubiquitin specific peptidase involved in the DNA Damage Response |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2011 |
| Completion Date: | 08/2014 |
| Project Title: | Role of ATM Signaling in PALB2-dependent Homologous Recombination DNA Repair |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 10/2012 |
| Project Title: | Molecular and Functional Characterisation of DYRK1A in DNA Damage Signaling and Repair |
| Investigator(s): | Huen MSY, Sy MH |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2013 |
| Project Title: | Study of the PALB2-Plk1 module in Cell Cycle Checkpoint Control and Maintenance of Genome Stability |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2014 |
| Project Title: | Study Role of PCNA-binding protein TRAIP in Replicative Stress Responses and Tumor Suppression |
| Investigator(s): | Huen MSY, Feng W |
| Department: | Anatomy |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2014 |
| Project Title: | Examining Negative Regulatory Mechanisms of DNA Damage Signal Transduction & Their Impact on Maintenance of Genome Stability |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Keystone Symposia: Genomic Instability and DNA Repair; A PCNA clamp unloader at stressed replication forks |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2015 |
| Completion Date: | 03/2015 |
| Project Title: | Role of UBE2U in DNA Damage Signaling and Repair |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Chen H., Xu J., Zhou Y., Gao Y., Wang G., Xia J., Huen M.S.Y., Siok W.T., Jiang Y., Tan L.H. and Sun Y., Association study of stuttering candidate genes GNPTAB, GNPTG and NAGPA with dyslexia in Chinese population, BMC Genetics. 2015, 16: 7. |
| Wang G., Zhou Y., Gao Y., Chen H., Xia J., Xu J., Huen M.S.Y., Siok W.T., Jiang Y., Tan L. and Sun Y., Association of specific language impairment candidate genes CMIP and ATP2C2 with developmental dyslexia in Chinese population, Journal of Neurolinguistics. 2015, 33: 163-171. |
| Researcher : Hui CC |
| List of Research Outputs |
| WEN S., Tan Z., Hui C.C., Chan D. and Cheah K.S.E., Functional roles for Irx3 and Irx5 in the hypertrophic chondrocyte to osteoblast lineage programme, Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.. 2015. |
| Researcher : JIANG Q |
| List of Research Outputs |
| JIANG Q., SHI W., DE NOGUEIRA BOTELHO F.P., Ma C.W., Lai C.H., Shum D.K.Y. and Chan Y.S., Developmental modulation of long-term plasticity at vestibular GABAergic synapses, Journal of Neurochemistry , 130 Suppl 1: 65. 2014. |
| Researcher : Jia LJ |
| Project Title: | To evaluate the functional significance of transcriptome changes upon Epstein-Barr virus infection in starvation-resistant growth of nasopharyngeal epithelial cells. |
| Investigator(s): | Jia LJ, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2014 |
| Project Title: | AACR Annual Meeting 2015; Establishment and characterization of immortalized nasopharyngeal epithelial cells with stable infection of Epstein-Barr virus |
| Investigator(s): | Jia LJ |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2015 |
| Completion Date: | 04/2015 |
| List of Research Outputs |
| Jia L.J., Tsang C.M., Yip Y.L., Law W.T., Zhang J. and Tsao G.S.W., Establishment and characterization of immortalized nasopharyngeal epithelial cells with stable infection of Epstein-Barr virus, AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. 2015. |
| Researcher : Jin D |
| Project Title: | Mitotic checkpoint and genomic stability in ovarian cancer |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | National Institutes of Health, US Department of Health and Human Services - General Award |
| Start Date: | 09/2002 |
| Project Title: | Roles for p21-activated protein kinase 3 in HTLV-I pathogenesis |
| Investigator(s): | Jin D, Ching YP |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2006 |
| Project Title: | Outstanding Researcher Award 2007-2008 |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Outstanding Researcher Award |
| Start Date: | 10/2008 |
| Project Title: | 4th Intracellular Proteolysis Meeting on Ubiquitin-proteasome System, Dynamics and Targeting REV7-mediated polyubiquitination and degradation of human REV1 |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2009 |
| Project Title: | Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy |
| Investigator(s): | Jin D, Kok KH, Lei T |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Support Programme (Tier 3) |
| Start Date: | 01/2010 |
| Project Title: | Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 01/2010 |
| Project Title: | Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 01/2010 |
| Project Title: | Mapping of peptide sequence in swine-origin H1N1 influenza virus hemagglutinin associated with the induction of anti-ganglioside antibodies implicated in Guillain-Barre syndrome: a pilot study |
| Investigator(s): | Jin D, Zheng B |
| Department: | Biochemistry |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2011 |
| Project Title: | Molecular mechanisms of innate antiviral response |
| Investigator(s): | Jin D, Kok KH, Lau ASY, Sham MH, Yuen KY, Zheng B |
| Department: | Biochemistry |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 06/2012 |
| Project Title: | Roles of LKB1 tumor suppressor in human T-cell leukemia virus type I transcription and leukemogenesis |
| Investigator(s): | Jin D, Tang HMV |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2012 |
| Project Title: | Molecular dissection of NSs virulence factor in severe fever with thrombocytopenia syndrome virus (SFTSV), a novel bunyavirus identified in China |
| Investigator(s): | Jin D, Kok KH |
| Department: | Biochemistry |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2013 |
| Project Title: | Roles of Epstein-Barr virus-encoded miR-BART microRNAs in viral persistence and transformation of epithelial cells |
| Investigator(s): | Jin D, Huang J, Tang HMV |
| Department: | Biochemistry |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2013 |
| Project Title: | Roles of CRTC coactivators in hepatitis B virus X protein-mediated activation of CREB-dependent transcription |
| Investigator(s): | Jin D, Zheng B, Zhou J, Tang HMV |
| Department: | Biochemistry |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2013 |
| Project Title: | Anti-hepatitis B virus activity of Resveratrol and mechanism of action |
| Investigator(s): | Jin D, Zhou J |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2013 |
| Completion Date: | 04/2015 |
| Project Title: | Molecular Mechanisms of Innate Immunity |
| Investigator(s): | Jin D, Lu L, Lau ASY, Tu W |
| Department: | Biochemistry |
| Source(s) of Funding: | Croucher Foundation - Conference / Seminars |
| Start Date: | 06/2013 |
| Project Title: | Roles of SIRT1 deacetylase in human T-cell leukemia virus type I transcription and leukemogenesis |
| Investigator(s): | Jin D, Ching YP, Tu W |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Regulatory roles of SIRT1 deacetylase in hepatitis B virus transcription |
| Investigator(s): | Jin D, Zhou J, Tang HMV |
| Department: | Biochemistry |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2014 |
| Project Title: | Mechanism of inflammasome activation by SARS coronavirus 3a protein |
| Investigator(s): | Jin D, Zheng B, Tang HMV |
| Department: | Biochemistry |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2014 |
| Project Title: | Immunostimulatory RNA in live attenuated measles vaccine |
| Investigator(s): | Jin D, Kok KH |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 06/2014 |
| Completion Date: | 05/2015 |
| Project Title: | Characterization of a novel cGAMP-hydrolyzing phosphodiesterase encoded by Middle East respiratory syndrome coronavirus |
| Investigator(s): | Jin D, Tse H |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | 16th International Symposium on EBV and Assocaited Diseases; Roles of Epstein-Barr virus-encoded BART microRNAs in viral persistence and nasopharyngeal carcinogenesis |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2014 |
| Completion Date: | 07/2014 |
| Project Title: | Outstanding Research Student Supervisor Award 2013-14 |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Outstanding Research Student Supervisor Award |
| Start Date: | 12/2014 |
| Project Title: | Identification and characterization of human cyclic dinucleotide phosphodiesterases that hydrolyze cGAMP second messenger |
| Investigator(s): | Jin D, Tse H |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Novel regulatory mechanisms in RIG-I-dependent innate antiviral response |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Croucher Senior Research Fellowships in Natural Sciences, Technology and Medicine |
| Start Date: | 01/2015 |
| Project Title: | Characterization of a novel β-TrCP-dependent pathway for ubiquitination and degradation of liver-enriched transcription factor CREB-H |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2015 |
| List of Research Outputs |
| CHENG Y., Tang H.M.V., GAO W., Deng J., Chan C.P. and Jin D., bTrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H, The 15th International Symposium of the Society of Chinese Bioscientists in America. 2015. |
| Chan C.P., YUEN C.K., FUNG S.Y., KEW C., Zheng B., Yuen K.Y. and Jin D., Influenza A virus NS1 protein targets double-stranded RNA binding protein PACT to suppress innate antiviral response, Innate Immune Memory: A Wellcome Trust Scientific Conference. 2015. |
| Jin D., Outstanding Research Student Supervisor Award, The University of Hong Kong. 2015. |
| Jin D., Tang H.M.V., GAO W., Chan C.P. and Yuen K.S., Retroviral oncoprotein Tax-induced activation of LKB1-SIK and SIRT1 signaling in the regulation of HTLV-1 transcription, The 15th International Symposium of the Society of Chinese Bioscientists in America. 2015. |
| Researcher : KHONG ML |
| List of Research Outputs |
| KHONG M.L., Li L., Lu B., Watt R.M. and Tanner J.A., Towards demystifying the implications of polyphosphate-protein binding., Hong Kong Inter-University Postgraduate Symposium on Life Science 2015, Hong Kong. 2015. |
| Researcher : KINGHORN AB |
| List of Research Outputs |
| FRASER L.A., TANG Y.H., KINGHORN A.B., Shum H.C. and Tanner J.A., Enriching catalytic DNA., Hong Kong Inter-University Postgraduate Symposium on Life Science 2015, Hong Kong. 2015. |
| KINGHORN A.B. and Tanner J.A., Aptamer library resampling., 2014 East-West Alliance Global Symposia, Hong Kong. 2014. |
| KINGHORN A.B. and Tanner J.A., Best oral presentation prize, Hong Kong Inter-University Postgraduate Symposium on Life Science 2015. 2015. |
| KINGHORN A.B. and Tanner J.A., DNA display and methods thereof. PCT International Application, Patent PCT/CN2015/073350. 2015. |
| KINGHORN A.B. and Tanner J.A., Resampling of aptamer libraries to isolate the highest affinity binders, Hong Kong Inter-University Postgraduate Symposium on Life Science 2015, Hong Kong. 2015. |
| TANG S.L.M., Godonoga M., DIRKZWAGER R.M., KINGHORN A.B. and Heddle J.G., Aptamer-functionalized DNA origami: an emerging tool for malaria diagnosis., Hong Kong Inter-University Postgraduate Symposium on Life Science 2015, Hong Kong. 2015. |
| TANG S.L.M., Godonoga M., DIRKZWAGER R.M., KINGHORN A.B., Heddle J.G. and Tanner J.A., Best poster presentation prize, HKU 19th Research Postgraduate Symposium, Hong Kong 2014. 2014. |
| Researcher : Keung WWY |
| Project Title: | Driving maturation of human embryonic stem cell-derived cardiomyocytes through metabolic conditioning in 2D and 3D environment |
| Investigator(s): | Keung WWY |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 09/2014 |
| Project Title: | International Society for Stem Cell Research 2015 Annual Meeting; Engineering a high-biofidelity, mechanically and electrophysiologically functional 3D human ventricular pump from pluripotent stem cells: A human cell-based bioartificial heart prototype |
| Investigator(s): | Keung WWY |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Poon N.Y.E., Keung W.W.Y. and Yan B., Proteomic Analysis of Human Pluripotent Stem Cell–Derived, Fetal, and Adult Ventricular Cardiomyocytes Reveals Pathways Crucial for Cardiac Metabolism and MaturationCLINICAL PERSPECTIVE, Circulation: Cardiovascular Genetics. 2015, 8: 427-436. |
| Researcher : Kudelko MA |
| Project Title: | Computational Mass Spectrometry-Based Proteomics; Chondrocyte Cells at the banks of the River Styx |
| Investigator(s): | Kudelko MA |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2014 |
| Completion Date: | 07/2014 |
| List of Research Outputs |
| Kudelko M.A., Chan C.C.Y., YAO Q., Cheah K.S.E., Tanner J.A. and Chan D., Hypertrophic Chondrocytes Survive ER Stress by Maintaining Glycolysis and Mitochondrial Membrane Poloarity., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015. |
| Tam V., Sharma R., Kudelko M.A., Cheah K.S.E., Lam Y.W. and Chan D., Intervertebral disc cell biosynthesis in the degenerate and non-degenerate intervertebral disc., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.. 2015. |
| Researcher : Kwok LF |
| List of Research Outputs |
| Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilization of Chondroitinase ABC-I and -II on Chitosan Microbeads Improve Neurite Growth in CSPG-Enriched Astrocyte Culture, 10th International Symposium on Healthy Aging: A Decade of Positive Aging. 2015. |
| Researcher : LAM CF |
| List of Research Outputs |
| LAM C.F. and Ng R.K., The role of CYBB in maintenance of MLL-rearranged leukemia, 20th Congress of European Hematology Association (EHA) June 11-14, 2015, Vienna, Austria. 2015. |
| Researcher : LAM Y |
| List of Research Outputs |
| LAM Y., FENG C., Chan W.C.W., Cheah K.S.E., Chan B.P. and Chan D., Understanding the contribution of Lgr5+ interzone progenitor cells in articular cartilage regeneration., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015. |
| Researcher : LI T |
| List of Research Outputs |
| LI T., ZHENG F., Cheung M.C.H., Wang F.S. and Fu C., Fission yeast mitochondria are distributed by dynamic microtubules in a motor-independent manner, Scientific Reports. Nature Publishing Group, 2015, 5: 1-10. |
| Researcher : LIANG S |
| List of Research Outputs |
| LIANG S. and Tanner J.A., Development of an aptasensor for monitoring luteinizing hormone pulsatility – a tool to improve the management of anovulatory subfertility., Hong Kong Inter-University Postgraduate Symposium on Life Science 2015, Hong Kong. 2015. |
| Researcher : Lai KO |
| Project Title: | Investigating arginine methylation of synaptic proteins and its potential function in dendritic spine development |
| Investigator(s): | Lai KO |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 07/2014 |
| Project Title: | Scientific Conferences for the Chinese Association for Physiological Sciences; Cdk5-mediated phosphorylation is required for the development and plasticity of dendritic spines |
| Investigator(s): | Lai KO |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2014 |
| Completion Date: | 10/2014 |
| Project Title: | Investigating the functional role of a novel synaptic protein TBC1D24 in activity-dependent spine morphogenesis. |
| Investigator(s): | Lai KO |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2014 |
| List of Research Outputs |
| Lai K.O., Liang Z., Fei E., Huang H. and Ip N.Y., Cyclin-dependent Kinase 5 (Cdk5)-dependent Phosphorylation of p70 Ribosomal S6 Kinase 1 (S6K) Is Required for Dendritic Spine Morphogenesis., Journal of Biological Chemistry. The American Society for Biochemistry and Molecular Biology,, 2015, 290: 14637-14646. |
| Researcher : Lai WL |
| Project Title: | An investigation on the role of Tax1 binding protein 2 in the DNA damage response in hepatocellular carcinoma |
| Investigator(s): | Lai WL, Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2013 |
| Completion Date: | 11/2014 |
| List of Research Outputs |
| Ching Y.P. and Lai W.L., The centrosomal protein, TAX1 binding protein 2 (TAX1BP2) regulates the chemo-sensitivity of liver cancer cells, WIN 2015 Symposium. 2015, Abstract code: P6.04. |
| Researcher : Lam YM |
| List of Research Outputs |
| Lam Y.M. and Ng R.K., Epigenetic function of Bmi-1 in the regulation of hematopoietic stem cell self-renewal, International Society For Stem Cell Research (ISSCR) 13th Annual Meeting June 24-27, 2015, Stockholm, Sweden. 2015. |
| Researcher : Lau CYW |
| Project Title: | Structural Role of the BRCA1-PALB2-BRCA2 Complex in DNA Repair |
| Investigator(s): | Lau CYW, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 02/2015 |
| List of Research Outputs |
| Lau C.Y.W., Single-particle electron microscopy analysis of macromolecular assemblies. 2015. |
| Researcher : Li B |
| Project Title: | Suppressive effects of Id1-targeting microRNAs in metastasis of esophageal cancer |
| Investigator(s): | Li B, Cheung A |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2013 |
| Completion Date: | 11/2014 |
| List of Research Outputs |
| HAN L., Li B., Tsao G.S.W. and Cheung A., Roles of miR-338-5p in downregulating Id1 and inhibiting chemoresistance, Non-Coding RNAS 2015, International Conference "The long and the short of non- Coding RNAs", Chania, Greece, June 14-19, 2015. |
| Researcher : Li L |
| List of Research Outputs |
| KHONG M.L., Li L., Lu B., Watt R.M. and Tanner J.A., Towards demystifying the implications of polyphosphate-protein binding., Hong Kong Inter-University Postgraduate Symposium on Life Science 2015, Hong Kong. 2015. |
| Researcher : Li SK |
| Project Title: | Transcriptome Analysis of Tumor Suppressor Gene TAX1BP2 by Next-Generation Sequencing |
| Investigator(s): | Li SK, Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2014 |
| List of Research Outputs |
| Tang H.C., Li S.K. and Ching Y.P., HBx deregulates centrosome integrity and induces genomic instability in Hepatocellular Carcinoma, In: Keystone Symposia , Keystone Conference - Viruses and Human Cancer. Montana, USA, 2015. |
| Researcher : Lui WT |
| List of Research Outputs |
| WONG P.Y., Chan K.H., Lui W.T. and Wong N.S., The 3’-untranslated region of CHOP mRNA encodes information that determines the expression level of the CHOP gene, 2015. |
| Researcher : Ng RK |
| Project Title: | The functional role of epigenetic memory in the differentiation plasticity of induced pluripotent stem cells |
| Investigator(s): | Ng RK |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Project Title: | Function of PRMT1 in the establishment of leukemia stem cell |
| Investigator(s): | Ng RK |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2013 |
| Project Title: | The role of PRMT1 in activation of leukemia stem cell program in MLL-rearranged leukemia |
| Investigator(s): | Ng RK, Yiu SM, Chan LC |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Function of polycomb protein Bmi-1 in hematopoietic Wnt signaling pathway |
| Investigator(s): | Ng RK |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | International Society for Stem Cell Research ISSCR 2015 Annual Meeting; Epigenetic function of Bmi-1 in the regulation of hematopoietic stem cell self-renewal |
| Investigator(s): | Ng RK |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2015 |
| Project Title: | Dysregulation of DNA methylation in MLL-rearranged leukemia |
| Investigator(s): | Ng RK |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2015 |
| List of Research Outputs |
| LAM C.F. and Ng R.K., The role of CYBB in maintenance of MLL-rearranged leukemia, 20th Congress of European Hematology Association (EHA) June 11-14, 2015, Vienna, Austria. 2015. |
| Lam Y.M. and Ng R.K., Epigenetic function of Bmi-1 in the regulation of hematopoietic stem cell self-renewal, International Society For Stem Cell Research (ISSCR) 13th Annual Meeting June 24-27, 2015, Stockholm, Sweden. 2015. |
| Popp C. and Ng R.K., Histone variant H3.3 and epigenetic memory in iPS cells, The Croucher Foundation Advanced Study Institute (ASI) on Stem Cells: Biology and Applications January 5- 7, 2015, Hong Kong. 2015. |
| Popp C. and Ng R.K., Role of histone variants H3.3 and H2A.Z in epigenetic memory of iPS cells, EMBO conference: Chromatin and Epigenetics May 6-10, 2015, Heidelberg, Germany. 2015. |
| Researcher : Ng VCW |
| List of Research Outputs |
| YAO Q., Chan W.C.W., Ng V.C.W., Tan Z., Tsang K.Y., Cheah K.S.E. and Chan D., Hypertrophic chondrocytes under ER stress utilizes the hypoxia stress pathway for survival., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.. 2015. |
| Researcher : Poon NYE |
| Project Title: | The effect of miR-200c on the electrophysiological maturation of human embryonic stem cell derived cardiomyocytes |
| Investigator(s): | Poon NYE, Boheler KR, Li RA |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2014 |
| List of Research Outputs |
| Poon N.Y.E., Consensus Comparative Analysis of Human Embryonic Stem Cell-Derived Cardiomyocytes, PLOS ONE. 2015, 10: e0125442. |
| Poon N.Y.E., Keung W.W.Y. and Yan B., Proteomic Analysis of Human Pluripotent Stem Cell–Derived, Fetal, and Adult Ventricular Cardiomyocytes Reveals Pathways Crucial for Cardiac Metabolism and MaturationCLINICAL PERSPECTIVE, Circulation: Cardiovascular Genetics. 2015, 8: 427-436. |
| Researcher : Popp C |
| Project Title: | The role of H2A.Z in epigenetic memory in induced pluripotent stem cells |
| Investigator(s): | Popp C, Ng RK |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2015 |
| Project Title: | Chromatin and Epigenetics 2015; Role of histone variants H3.3 and H2A.Z in epigenetic memory in induced pluripotent stem cells |
| Investigator(s): | Popp C |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2015 |
| List of Research Outputs |
| Popp C. and Ng R.K., Histone variant H3.3 and epigenetic memory in iPS cells, The Croucher Foundation Advanced Study Institute (ASI) on Stem Cells: Biology and Applications January 5- 7, 2015, Hong Kong. 2015. |
| Popp C. and Ng R.K., Role of histone variants H3.3 and H2A.Z in epigenetic memory of iPS cells, EMBO conference: Chromatin and Epigenetics May 6-10, 2015, Heidelberg, Germany. 2015. |
| Researcher : Qian C |
| Project Title: | Structural and Mechanistic Analysis of Human SMARCAL1 |
| Investigator(s): | Qian C, Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2011 |
| Project Title: | Structural and Mechanistic Characterization of XPA-associated Complexes in Nucleotide Excision Repair Pathway |
| Investigator(s): | Qian C |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2012 |
| Project Title: | Structure-Based Mechanistic Insights into Timeless-Involved Replication Fork Protection |
| Investigator(s): | Qian C |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2013 |
| Project Title: | Structural analysis of Human SLX1-SLX4 Complex in DNA Repair |
| Investigator(s): | Qian C |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Structural and Mechanistic Studies of Human SLX4 Complex in Interstrand Crosslink Repair |
| Investigator(s): | Qian C |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2014 |
| List of Research Outputs |
| Qian C., New Mechanistic Insights into DNMT1 Mediated Maintenance DNA Methylation, Gordon Research Conference on Genome Architecture in Cell Fate & Disease. 2015. |
| Researcher : SHAH AN |
| List of Research Outputs |
| Chan W.C.W., SHAH A.N., Cheng C.C.W., Cheah K.S.E. and Chan D., Differentiation and migration of endplate chondrocytes contribute to the inner annulus fibrosus in normal and degenerative intervertebral disc., Cartilage Biology & Pathology Gordon Research Conference. Galveston, TX, USA, March 22-27, 2015.. 2015. |
| SHAH A.N., Chan W.C.W. and Chan D., The Role of Hypertrophic Chondrocyte and Cellular Stress in Intervertebral Disc Integrity and Degeneration., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.. 2015. |
| Researcher : Shum DKY |
| Project Title: | 30th Annual Conference of Society for Neuroscience Effects of Chondroitin Sulfate Supplements on Regeneration of Bridged Sciatic Nerves |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2000 |
| Project Title: | 31st Annual Meeting of Society for Neuroscience Expression of Chondroitin 6-sulfotransferase mRNA and the Sulfation Product in Post-crush Sciatic Nerves of Adult Rats |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2001 |
| Project Title: | Expression of heparanase in the injured spinal cord |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Project Title: | 33rd Annual Conference of the Society for Neuroscience Spatiotemporal Expression of Chondroitin 6-Sulfotransferase (C6ST) In Regeneration of Crush-injured Sciatic Nerves of Adult Rats C6ST Expression in Sciatic Nerve Explant Culture of Adult Rats |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2003 |
| Project Title: | Expression of chondroitin sulfotransferases in the injured spinal cord |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Project Title: | Proteoglycans in Signaling Heparan Sulfate/Syndecan-1 Modulates the Balance between Proteinase and Anti-Proteinase in Bronchiectasis |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2005 |
| Project Title: | Heparan sulfate oligosaccharide preparations - novel therapeutics in chronic inflammation |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 10/2007 |
| Project Title: | Use of a rat model of chronic obstructive pulmonary disease to address neutrophil elastase/anti-elastase imbalance in the airways |
| Investigator(s): | Shum DKY, Ip MSM, Chan CH |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 12/2008 |
| Project Title: | A Novel Nerve Conduit that Combines Schwann Cell-seeded Chitosan Nanofibres with Chondroitinase ABC-loaded Chitosan Microbeads for Post-traumatic Nerve Regeneration |
| Investigator(s): | Shum DKY, Chan YS, Tam KW |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Support Programme (Tier 3) |
| Start Date: | 07/2011 |
| Project Title: | A Novel Nerve Conduit that Combines Schwann Cell-seeded Chitosan Nanofibres with Chondroitinase ABC-loaded Chitosan Microbeads for Post-traumatic Nerve Regeneration |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 07/2011 |
| Project Title: | Proheparanase and AMPA receptor trafficking in synaptic plasticity |
| Investigator(s): | Shum DKY, Chan YS |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2011 |
| Project Title: | From bone marrow stromal cells to Schwann cells – in vitro route to specification and utility in re-myelination therapy |
| Investigator(s): | Shum DKY, Chan YS |
| Department: | Biochemistry |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2012 |
| Project Title: | Tuning sulfation of chondroitins at perineuronal nets regulate plasticity of central vestibular synapse |
| Investigator(s): | Shum DKY, Chan YS |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Project Title: | Neuroscience 2014; Oligodendrocyte and Schwann Cell Biology - Juxtacrine signalling via Notch and ErbB receptors in the switch to fate commitment of bone marrow-derived Schwann cells. |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2014 |
| Completion Date: | 11/2014 |
| List of Research Outputs |
| Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilization of Chondroitinase ABC-I and -II on Chitosan Microbeads Improve Neurite Growth in CSPG-Enriched Astrocyte Culture, 10th International Symposium on Healthy Aging: A Decade of Positive Aging. 2015. |
| Tai W.Y.E., Shea G.K.H., Leung H.Y., Tsui Y.P., Chan Y.S. and Shum D.K.Y., INSTRUCTIVE ROLE OF DRG NEURONS IN DERIVATION OF SCHWANN CELLS FROM BONE MARROW STROMAL CELLS, Tenth International Symposium on Healthy Aging “A Decade of Positive Aging”. 2015. |
| Tam K.W., Chan Y.S. and Shum D.K.Y., Stability and Kinetics of Chondroitinase ABC in Macromolecular Crowded Environment, 10th International Symposium on Healthy Aging: A Decade of Positive Aging. 2015. |
| Tsui Y.P., Shum D.K.Y. and Chan Y.S., Towards remyelination: derivation of oligodendrocyte precursors and Schwann cells from neural progenitors harbored by adult bone marrow stromal cells, Cold Spring harbor Asia Conference: Novel Insights into Glia Function & Dysfunction. 2015. |
| Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Nerve Conduit Constructed by Aligned Chitosan Nanofibers for Directing Axonal Growth in Nerve Regeneration, 10th International Symposium on Healthy Aging: A Decad of Positive Aging. 2015. |
| Researcher : Song Y |
| Project Title: | A Randomized Controlled Trial of the Therapeutic Effects of Tai Chi and Mahjong on Older Persons With Cognitive Impairment |
| Investigator(s): | Song Y |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2008 |
| Project Title: | Identification of a genetic variant for heart defects (CHD) on chromosome 15 in mice |
| Investigator(s): | Song Y, Cheah KSE, Sham PC |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2012 |
| Project Title: | Investigation on Pax6 regulation of neuronal apoptosis in Alzheimer’s disease |
| Investigator(s): | Song Y |
| Department: | Biochemistry |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2013 |
| Project Title: | Study of Population Specific Linkage Disequilibrium (LD) Patterns of Human Major Histocompatibility Complex (MHC) Region for Cancers, Infectious and Autoimmunity Diseases in Southern Chinese |
| Investigator(s): | Song Y, Sham PC, Fan Y |
| Department: | Biochemistry |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2014 |
| Project Title: | The role of hnrnpa1 in human congenital heart defects |
| Investigator(s): | Song Y, Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2014 |
| Project Title: | Repurposing the approved drugs for prevention and treatment of Alzheimer’s disease in transgenic mouse models |
| Investigator(s): | Song Y, Chu LW |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 06/2014 |
| Project Title: | Modeling host susceptibility to influenza H7N9 virus in inbred mice: a pilot study |
| Investigator(s): | Song Y, Yeung ML, Kok KH |
| Department: | Biochemistry |
| Source(s) of Funding: | Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential |
| Start Date: | 10/2014 |
| Project Title: | Targeted sequencing to identify of genes on candidate loci causing Adolescent Idiopathic Scoliosis (AIS) |
| Investigator(s): | Song Y, Luk KDK, Chan D, Sham PC, Cheung KMC |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2015 |
| List of Research Outputs |
| Li Y., Samartzis D., Campbell D., Cherny S.S., Cheung K.M.C., Luk K.D.K., Karppinen J., Song Y., Cheah K.S.E., Sham P.C. and Chan D., A novel pathway associated with lumbar disc degeneration: a genome-wide association study., 42nd International Society for the Study of the Lumbar Spine. San Francisco. June 8-12, 2015.. 2015. |
| Li Y., Kao P., Yip M.S., Sze K.L., Fosang A., McCulloch D., Cheung K.M.C., Samartzis D., Luk K.D.K., Karppinen J., Song Y., Cheah K.S.E., Sham P.C. and Chan D., Association and functional analysis of ADAMTS5 in lumbar disc degeneration, 42nd International Society for the Study of the Lumbar Spine. San Francisco. June 8-12, 2015.. 2015. |
| XIONG C., Li Y., Muhammad, F.R., ., Sandell L., Chan W.C.W., Tam V., ZHANG Y., Song Y. and Cheah K.S.E., Sham P.C., Chan D., Understanding the genetic contribution to endogenous self-protective potentials of intervertebral disc., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.. 2015. |
| Researcher : Szeto YY |
| Project Title: | Transcriptional regulation of Aqp3 by Sox9 and Sox9Y440X in the mouse inner ear |
| Investigator(s): | Szeto YY, Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2012 |
| List of Research Outputs |
| Au Y.K., Wynn S., Szeto Y.Y., Geng Y.H., Tan T.Y., Cheung K.M.C. and Cheah K.S.E., Understanding the Molecular Impact of Sox9 Y440X in Campomelic Dysplasia., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015. |
| Szeto Y.Y., Au Y.K., Wu M.H., Dung W.F. and Cheah K.S.E., The role of Zic3 and BAF complex in notochord cell lineage progression, Gordon Research Conference: Genome Architecture in Cell Fate & Disease Hong Kong, Jun 7-12, 2015.. 2015. |
| Researcher : TANG SLM |
| List of Research Outputs |
| TANG S.L.M., Godonoga M., DIRKZWAGER R.M., KINGHORN A.B. and Heddle J.G., Aptamer-functionalized DNA origami: an emerging tool for malaria diagnosis., Hong Kong Inter-University Postgraduate Symposium on Life Science 2015, Hong Kong. 2015. |
| TANG S.L.M., Godonoga M., DIRKZWAGER R.M., KINGHORN A.B., Heddle J.G. and Tanner J.A., Best poster presentation prize, HKU 19th Research Postgraduate Symposium, Hong Kong 2014. 2014. |
| Researcher : Tam KW |
| List of Research Outputs |
| Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilization of Chondroitinase ABC-I and -II on Chitosan Microbeads Improve Neurite Growth in CSPG-Enriched Astrocyte Culture, 10th International Symposium on Healthy Aging: A Decade of Positive Aging. 2015. |
| Tam K.W., Chan Y.S. and Shum D.K.Y., Stability and Kinetics of Chondroitinase ABC in Macromolecular Crowded Environment, 10th International Symposium on Healthy Aging: A Decade of Positive Aging. 2015. |
| Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Nerve Conduit Constructed by Aligned Chitosan Nanofibers for Directing Axonal Growth in Nerve Regeneration, 10th International Symposium on Healthy Aging: A Decad of Positive Aging. 2015. |
| Researcher : Tam PLP |
| List of Research Outputs |
| Wang X., Cheung M.C.H., Tam P.L.P., Briscoe J. and Chan D., Molecular and Cellular Consequences of Indian Hedgehog Mutations Causing Brachydactylies, Cartilage Biology & Pathology. Gordon Research Conference. Galveston, TX. USA. March 22-27, 2015.. 2015. |
| Researcher : Tam V |
| Project Title: | Computational Mass Spectrometry-Based Proteomics, 6th MaxQuant Summer School; Using proteomics to identify changes from health to degeneration in the intervertebral disc. |
| Investigator(s): | Tam V |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2014 |
| Completion Date: | 07/2014 |
| Project Title: | Understanding the role of clusterin in intervertebral disc degeneration |
| Investigator(s): | Tam V, Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Tam V., Sharma R., Kudelko M.A., Cheah K.S.E., Lam Y.W. and Chan D., Intervertebral disc cell biosynthesis in the degenerate and non-degenerate intervertebral disc., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.. 2015. |
| XIONG C., Li Y., Muhammad, F.R., ., Sandell L., Chan W.C.W., Tam V., ZHANG Y., Song Y. and Cheah K.S.E., Sham P.C., Chan D., Understanding the genetic contribution to endogenous self-protective potentials of intervertebral disc., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.. 2015. |
| Researcher : Tan TY |
| List of Research Outputs |
| Au Y.K., Wynn S., Szeto Y.Y., Geng Y.H., Tan T.Y., Cheung K.M.C. and Cheah K.S.E., Understanding the Molecular Impact of Sox9 Y440X in Campomelic Dysplasia., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015. |
| Cheah K.S.E., Au Y.K., Wynn S., Tan T.Y. and YIP K.H.R., Sox9 restrains chondrocyte to osteoblast lineage progression-implications for the pathogenesis of Campomelic Dysplasia., International Society for Stem Cell Research, ISSCR 2015 Annual Meeting. Stockholm, Sweden. 24-27 June 2015.. 2015. |
| YIP K.H.R., Tan T.Y., Cheung M.C.H. and Cheah K.S.E., Long-range regulation of Sox9 in development and disease., Gordon Research Conference: Genomic Architecture in Cell Fate & Disease Hong Kong Jun 7-12, 2015.. 2015. |
| Researcher : Tan Z |
| List of Research Outputs |
| Cheah K.S.E., Wang C., Tan Z., Tsang K.Y., Ron D., Itoh N. and Chan D., The PERK pathway attenuates ER stress in hypertrophic chondrocytes via SOX9 and FGF21., Cartilage Biology & Pathology Gordon Research Conference. Galveston, TX, USA, March 22-27, 2015.. 2015. |
| WEN S., Tan Z., Hui C.C., Chan D. and Cheah K.S.E., Functional roles for Irx3 and Irx5 in the hypertrophic chondrocyte to osteoblast lineage programme, Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.. 2015. |
| YAO Q., Chan W.C.W., Ng V.C.W., Tan Z., Tsang K.Y., Cheah K.S.E. and Chan D., Hypertrophic chondrocytes under ER stress utilizes the hypoxia stress pathway for survival., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.. 2015. |
| Researcher : Tan-Un KC |
| Project Title: | King's/HKU Fellowship Awards 2010-11 |
| Investigator(s): | Tan-Un KC |
| Department: | School of Biological Sciences |
| Source(s) of Funding: | King's/HKU Fellowship Awards |
| Start Date: | 06/2010 |
| Project Title: | Zearalenone-induced toxicity in cells |
| Investigator(s): | Tan-Un KC |
| Department: | School of Biological Sciences |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2011 |
| Project Title: | Characterization of the novel distal regulatory elements of the Neuroglobin gene |
| Investigator(s): | Tan-Un KC |
| Department: | School of Biological Sciences |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 02/2012 |
| Project Title: | CHARACTERISATION OF NOVEL DISTAL REGULATORY ELEMENTS OF THE NEUROGLOBIN GENE |
| Investigator(s): | Tan-Un KC |
| Department: | School of Biological Sciences |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2013 |
| List of Research Outputs |
| Chau P.H., Ngai H.H.Y., Leung A.Y.M., Li S.F. and Tan-Un K.C., Preference of food saltiness and willingness to consume low-sodium content food in a Chinese population, Poster presented at the Tenth International Symposium on Healthy Aging. Hong Kong, China, 7-8 March 2015. |
| Researcher : Tang HMV |
| List of Research Outputs |
| CHENG Y., Tang H.M.V., GAO W., Deng J., Chan C.P. and Jin D., bTrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H, The 15th International Symposium of the Society of Chinese Bioscientists in America. 2015. |
| Jin D., Tang H.M.V., GAO W., Chan C.P. and Yuen K.S., Retroviral oncoprotein Tax-induced activation of LKB1-SIK and SIRT1 signaling in the regulation of HTLV-1 transcription, The 15th International Symposium of the Society of Chinese Bioscientists in America. 2015. |
| Researcher : Tanner JA |
| Project Title: | Comparative Characterization of the Two Polyphosphate Kinases of M. tuberculosis |
| Investigator(s): | Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 02/2005 |
| Project Title: | Defining the Roles of the Fundamental Macromolecule Inorganic Polyphosphate in Osteoblasts |
| Investigator(s): | Tanner JA, Watt RM |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Project Title: | Investigating the Potential of 3-D Printing as a Transformative Technology for Point of Care Diagnostics |
| Investigator(s): | Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 05/2013 |
| Completion Date: | 10/2014 |
| Project Title: | 3-D Printed Aptamer-Enabled Diagnostic Dominoes for Malaria |
| Investigator(s): | Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Aptamer-mediated detection of luteinizing hormone pulsatility – a transformational approach towards managing infertility |
| Investigator(s): | Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Aptamer-mediated Point-of-Care Diagnostics (CRF) |
| Investigator(s): | Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding for Incubating Group-based Collaborative Research Projects |
| Start Date: | 01/2015 |
| Project Title: | DNA origami interfaced with aptamer-mediated molecular recognition for integrated modular diagnostics |
| Investigator(s): | Tanner JA, Watt RM |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Aptamers 2015 and Oligomer 2015 at Oxford University; Aptamer 2015: DNA aptamers for point-of-care malaria diagnosis - from crystal structure to clinical application using Aptamer Tethered Enzyme Capture (APTEC)/Oligo 2015: Highly selective DNA oligonucleotide aptamers against aggrecanase ADAMTS5 for degenerative disc disease therapy |
| Investigator(s): | Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2015 |
| Project Title: | Tetrapod Palindromic Capture Aptamers for Diagnostic Devices |
| Investigator(s): | Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Bevan S.J., Chan C.W.L. and Tanner J.A., Creative and collaborative assessment strategies sustain deep student learning: Evidence from a large introductory biochemical class., International Conference: Assessment for Learning in Higher Education 2015, Hong Kong. 2015. |
| Bevan S.J., Chan C.W.L. and Tanner J.A., Sustaining deep learning in first year biomedical sciences courses – a quantitative comparative study provides evidence for the benefits of diverse assessment and active student engagement., 12th Asia Pacific Medical Education Conference, Singapore (2015). 2015. |
| DIRKZWAGER R.M., Cheung Y.W., Richards J.S. and Tanner J.A., . New technologies for old diseases: the potential of DNA aptamers in point-of-care malaria diagnosis., . Hong Kong Inter-University Postgraduate Symposium on Life Science 2015, Hong Kong. 2015. |
| DIRKZWAGER R.M., Richard J.S. and Tanner J.A., A novel aptamer-based colorimetric test for malaria., 4th International Conference on Bio-Sensing Technology, Lisbon, Portugal (2015). 2015. |
| FRASER L.A., TANG Y.H., KINGHORN A.B., Shum H.C. and Tanner J.A., Enriching catalytic DNA., Hong Kong Inter-University Postgraduate Symposium on Life Science 2015, Hong Kong. 2015. |
| KHONG M.L., Li L., Lu B., Watt R.M. and Tanner J.A., Towards demystifying the implications of polyphosphate-protein binding., Hong Kong Inter-University Postgraduate Symposium on Life Science 2015, Hong Kong. 2015. |
| KINGHORN A.B. and Tanner J.A., Best oral presentation prize, Hong Kong Inter-University Postgraduate Symposium on Life Science 2015. 2015. |
| KINGHORN A.B. and Tanner J.A., DNA display and methods thereof. PCT International Application, Patent PCT/CN2015/073350. 2015. |
| KINGHORN A.B. and Tanner J.A., Resampling of aptamer libraries to isolate the highest affinity binders, Hong Kong Inter-University Postgraduate Symposium on Life Science 2015, Hong Kong. 2015. |
| Kudelko M.A., Chan C.C.Y., YAO Q., Cheah K.S.E., Tanner J.A. and Chan D., Hypertrophic Chondrocytes Survive ER Stress by Maintaining Glycolysis and Mitochondrial Membrane Poloarity., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015. |
| LIANG S. and Tanner J.A., Development of an aptasensor for monitoring luteinizing hormone pulsatility – a tool to improve the management of anovulatory subfertility., Hong Kong Inter-University Postgraduate Symposium on Life Science 2015, Hong Kong. 2015. |
| Tanner J.A., Bringing together DNA aptamer-mediated molecular recognition, nanotechnology and 3D printing for new approaches in medical diagnostics., Hong Kong Polytechnic University, Hong Kong. 2015. |
| Tanner J.A., Chair of Conference Session: Innovative Assessment Approaches., International Conference: Assessment for Learning in Higher Education 2015, Hong Kong (2015). 2015. |
| Tanner J.A., DNA aptamers for point-of-care malaria diagnosis – from crystal structure to clinical application using aptamer tethered enzyme capture (APTEC), Aptamers 2015 2nd Oxford Symposium on Aptamers, Oxford University, United Kingdom. 2015. |
| Wong G.T.C., Jenkins C.R., Tsang J.W.H., Chen J.Y., Chan L.C. and Tanner J.A., Use of film to build student empathy and enable reflective thought in a new Medical Humanities programme embedded within the undergraduate MBBS curriculum., 12th Asia Pacific Medical Education Conference, Singapore (awarded Finalist prize in the Free Communication Session) (2015). 2015. |
| YU Y. and Tanner J.A., Highly selective DNA oligonucleotide aptamers against aggrecanase ADAMTS5 for degenerative disc disease therapy., Oligo 2015 Oxford: Antisense and Therapeutic Nucleic Acids, Oxford University, United Kingdom (2015). 2015. |
| Researcher : Tsang CM |
| Project Title: | The biological significance of TGF-β1 in sensitizing the nasopharyngeal epithelial cells to EBV infection |
| Investigator(s): | Tsang CM, Yip YL, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2013 |
| Project Title: | The protective role of Epstein-Barr virus infection towards starvation-induced apoptosis |
| Investigator(s): | Tsang CM, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2014 |
| List of Research Outputs |
| Jia L.J., Tsang C.M., Yip Y.L., Law W.T., Zhang J. and Tsao G.S.W., Establishment and characterization of immortalized nasopharyngeal epithelial cells with stable infection of Epstein-Barr virus, AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. 2015. |
| Tsao G.S.W., Tsang C.M., To K.F. and Lo K.W., The role of Epstein-Barr virus in epithelial malignancies, The Journal of Pathology. 2015, 235: 323-333. |
| Tsao G.S.W. and Tsang C.M., The role of Epstein-Barr virus infection in the pathogenesis of nasopharyngeal carcinoma, Virologica Sinica. 2015, 30: 107-121. |
| Researcher : Tsang KY |
| List of Research Outputs |
| Cheah K.S.E., Wang C., Tan Z., Tsang K.Y., Ron D., Itoh N. and Chan D., The PERK pathway attenuates ER stress in hypertrophic chondrocytes via SOX9 and FGF21., Cartilage Biology & Pathology Gordon Research Conference. Galveston, TX, USA, March 22-27, 2015.. 2015. |
| YAO Q., Chan W.C.W., Ng V.C.W., Tan Z., Tsang K.Y., Cheah K.S.E. and Chan D., Hypertrophic chondrocytes under ER stress utilizes the hypoxia stress pathway for survival., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.. 2015. |
| Researcher : Tsao GSW |
| Project Title: | Cancer |
| Investigator(s): | Tsao GSW, Poon RTP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 11/2008 |
| Project Title: | The role of TGF-beta in EBV infection and pathogenesis of nasopharyngeal carcinoma |
| Investigator(s): | Tsao GSW, Lan HY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2009 |
| Project Title: | The role of cyclin D1 in the persistence of Epstein-Barr virus (EBV) infection in premalignant nasopharyngeal epithelial cells. |
| Investigator(s): | Tsao GSW, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2011 |
| Completion Date: | 09/2014 |
| Project Title: | The role of ATM signaling in the lytic replication of Epstein-Barr virus in infected nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW, Chiang AKS, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Project Title: | Functional interaction of EBV-encoded BZLF1 with the DNA damage repair proteins |
| Investigator(s): | Tsao GSW, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2013 |
| Completion Date: | 04/2015 |
| Project Title: | Systematic Development of Molecular Targets for Nasopharyngeal Carcinoma |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 01/2014 |
| Project Title: | Dynamics of EBV episome maintenance in infected nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW, Chen H, Deng W |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Advances in Live Cell and Intravital Imaging in Biomedicine |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Croucher Foundation - Conference / Seminars |
| Start Date: | 03/2014 |
| Project Title: | Live cell imaging of invasion by EBV-infected nasopharyngeal epithelial cells. |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2014 |
| Project Title: | Regulation of invadopodia formation by the EBV-encoded LMP1 in nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Annual meeting 2015 of American Association for Cancer Research; The role of NF-kB activation in the immortalization of nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2015 |
| Completion Date: | 04/2015 |
| Project Title: | Delineating the signal pathways of LMP1 in the activation of mTOR signaling in nasopharyngeal carcinoma cells |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2015 |
| Project Title: | Establishment of a shared live cell imaging platform for super-resolution microscopy |
| Investigator(s): | Tsao GSW, Bruzzone R, Chang RCC, Cheung MCH, Ching YP, Fu C, Huen MSY, Jin D, Yang D, Yu C, Yuen KWY |
| Department: | Anatomy |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Major Equipment Project |
| Start Date: | 06/2015 |
| List of Research Outputs |
| HAN L., Li B., Tsao G.S.W. and Cheung A., Roles of miR-338-5p in downregulating Id1 and inhibiting chemoresistance, Non-Coding RNAS 2015, International Conference "The long and the short of non- Coding RNAs", Chania, Greece, June 14-19, 2015. |
| Jia L.J., Tsang C.M., Yip Y.L., Law W.T., Zhang J. and Tsao G.S.W., Establishment and characterization of immortalized nasopharyngeal epithelial cells with stable infection of Epstein-Barr virus, AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. 2015. |
| Lin W.T., Yip Y.L. and Tsao G.S.W., Cancer-Associated Fibroblasts Support Tumour Growth in Nasopharyngeal Carcinoma, Cell Symposia - Cancer, Inflammation, and Immunity. 2015. |
| Tsao G.S.W., Tsang C.M., To K.F. and Lo K.W., The role of Epstein-Barr virus in epithelial malignancies, The Journal of Pathology. 2015, 235: 323-333. |
| Tsao G.S.W. and Tsang C.M., The role of Epstein-Barr virus infection in the pathogenesis of nasopharyngeal carcinoma, Virologica Sinica. 2015, 30: 107-121. |
| Wang H.B., Zhang H., Zhang J.P., Li Y.L., Zhao B., Feng G.K., Du Y., Xiong D., Zhong Q., Liu W.L., Du H., Li M.Z., Huang W.L., Tsao G.S.W., Hutt-Fletcher L., Zeng Y.X., Kieff E. and Zeng M.S., Neuropilin 1 is an entry factor that promotes EBV infection of nasopharyngeal epithelial cells, Nature Communications. 2015, 6: 6240. |
| Yap L.F., Velapsasamy S.T., Lee H.M., Thavaraj S., Rajadurai P., Wei W.H., Vrzalikova K.C., Ibrahim M.H., Khoo A.S., Tsao G.S.W., Paterson I.C., Taylor G.S.W., Dawson C.W. and Murray P.G., Down-regulation of LPA receptor 5 contributes to aberrant LPA signalling in EBV-associated nasopharyngeal carcinoma, The Journal of Pathology. 2015, 235: 456-465. |
| Researcher : Tsui YP |
| Project Title: | Axonal regulation of peripheral nervous system glia identity |
| Investigator(s): | Tsui YP, Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Tai W.Y.E., Shea G.K.H., Leung H.Y., Tsui Y.P., Chan Y.S. and Shum D.K.Y., INSTRUCTIVE ROLE OF DRG NEURONS IN DERIVATION OF SCHWANN CELLS FROM BONE MARROW STROMAL CELLS, Tenth International Symposium on Healthy Aging “A Decade of Positive Aging”. 2015. |
| Tsui Y.P., Shum D.K.Y. and Chan Y.S., Towards remyelination: derivation of oligodendrocyte precursors and Schwann cells from neural progenitors harbored by adult bone marrow stromal cells, Cold Spring harbor Asia Conference: Novel Insights into Glia Function & Dysfunction. 2015. |
| Researcher : WEN S |
| List of Research Outputs |
| WEN S., Tan Z., Hui C.C. and Cheah K.S.E., Functional roles for Irx3 and Irx5 in osteoblast differentiation, Cold Spring Harbour Asia meeting in Suzhou(China), 3-7 Nov, 2014. |
| WEN S., Tan Z., Hui C.C., Chan D. and Cheah K.S.E., Functional roles for Irx3 and Irx5 in the hypertrophic chondrocyte to osteoblast lineage programme, Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.. 2015. |
| Researcher : WONG PY |
| List of Research Outputs |
| WONG P.Y., Chan K.H., Lui W.T. and Wong N.S., The 3’-untranslated region of CHOP mRNA encodes information that determines the expression level of the CHOP gene, 2015. |
| Researcher : Wang C |
| List of Research Outputs |
| Cheah K.S.E., Wang C., Tan Z., Tsang K.Y., Ron D., Itoh N. and Chan D., The PERK pathway attenuates ER stress in hypertrophic chondrocytes via SOX9 and FGF21., Cartilage Biology & Pathology Gordon Research Conference. Galveston, TX, USA, March 22-27, 2015.. 2015. |
| Researcher : Wang X |
| List of Research Outputs |
| Wang X., Cheung M.C.H., Tam P.L.P., Briscoe J. and Chan D., Molecular and Cellular Consequences of Indian Hedgehog Mutations Causing Brachydactylies, Cartilage Biology & Pathology. Gordon Research Conference. Galveston, TX. USA. March 22-27, 2015.. 2015. |
| Researcher : Wong NS |
| Project Title: | Kappa-opioid receptor mediated cellular stress response: the role of Inositol 1,4,5-trisphosphate and diacylglycerol |
| Investigator(s): | Wong NS, Yao KM |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2002 |
| Project Title: | Hydrogen peroxide signaling - the role of thioredoxin reductase |
| Investigator(s): | Wong NS |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2013 |
| Project Title: | The relatioship between glycolysis and gluconeogenesis in cancer cells |
| Investigator(s): | Wong NS |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2014 |
| List of Research Outputs |
| WONG P.Y., Chan K.H., Lui W.T. and Wong N.S., The 3’-untranslated region of CHOP mRNA encodes information that determines the expression level of the CHOP gene, 2015. |
| Wong N.S., Designing Formative Assessment For Medium Class-size Teaching In An Undergraduate Biochemistry Program, International Conference Assessment For Learning In Higher Education 2015. |
| Researcher : Wu MH |
| List of Research Outputs |
| Szeto Y.Y., Au Y.K., Wu M.H., Dung W.F. and Cheah K.S.E., The role of Zic3 and BAF complex in notochord cell lineage progression, Gordon Research Conference: Genome Architecture in Cell Fate & Disease Hong Kong, Jun 7-12, 2015.. 2015. |
| Researcher : XIONG C |
| List of Research Outputs |
| XIONG C., Li Y., Muhammad, F.R., ., Sandell L., Chan W.C.W., Tam V., ZHANG Y., Song Y. and Cheah K.S.E., Sham P.C., Chan D., Understanding the genetic contribution to endogenous self-protective potentials of intervertebral disc., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.. 2015. |
| Researcher : XU W |
| List of Research Outputs |
| CHEN X., XU W., Li N.F. and Chen J., Basic defect in cystic fibrosis, In: Burkhard Tümmler, Mutation-specific therapies in cystic fibrosis - Current status and prospects. Bremen, UNI-MED Science, 2014, 1st edition: 21-23. |
| Li N.F., XU W. and Chen J., Pseudomonas aeruginosa altered the transepithelial conductance of pig tracheal epithelia, The 30th Joint Annual Conference of Biomedical Science/The Chinese Physiological Society, Taiwan. 2015. |
| Li N.F., XU W. and Chen J., Pseudomonas aeruginosa infection casued a time-dependent increase in transepithelial conductance of pig tracheal epithelia, The 10th International Symposium on Healthy Aging, Hong Kong. 2015. |
| XU W., Li N.F. and Chen J., Sodium ion in the apical solution is associated with the volume-regulated ion transport in pig tracheal epithelia, The 30th Joint Annual Conference of Biomedical Science, Taiwan. 2015. |
| XU W., Li N.F. and Chen J., Sodium ion in the apical solution is essential for a fluid-induced reduction in amiloride-sensitive transepithelial currents, The 10th International Symposium on Healthy Aging. 2015. |
| Xu W., Li N.F. and Chen J., Apical incubation of Krebs solution may alter Na+ transport in pig tracheal epithelia, The 19th Research Postgraduate Symposium. 2014. |
| ZHU S., XU W., Li N.F. and Chen J., Effects of transepithelial bicarbonate transport in bacterial killing on the surface of cultured pig tracheal epithelia, The 10th International Symposium on Healthy Aging, Hong Kong. 2015. |
| Researcher : XUE W |
| List of Research Outputs |
| Cui J., Li X.L., Duan Z.Q., XUE W., Wong Z., Lu S., Lin R.Z., Liu M.F., Zhu G.X., Huang J. and Long D., Analysis of Kif5b Expression during Mouse Kidney Development, PLOS ONE. 2015, 10: e0126002. |
| Researcher : YIP KHR |
| List of Research Outputs |
| Cheah K.S.E., Au Y.K., Wynn S., Tan T.Y. and YIP K.H.R., Sox9 restrains chondrocyte to osteoblast lineage progression-implications for the pathogenesis of Campomelic Dysplasia., International Society for Stem Cell Research, ISSCR 2015 Annual Meeting. Stockholm, Sweden. 24-27 June 2015.. 2015. |
| YIP K.H.R., Au Y.K., Yang W., Chan D. and Cheah K.S.E., Investigating impact of Sox9 dysfunction in hypertrophic chondrocytes-to-osteoblasts transition., Gordon Research Conference: Cartilage Biology and Pathology TX, USA Mar 22-27, 2015.. 2015. |
| YIP K.H.R., Tan T.Y., Cheung M.C.H. and Cheah K.S.E., Long-range regulation of Sox9 in development and disease., Gordon Research Conference: Genomic Architecture in Cell Fate & Disease Hong Kong Jun 7-12, 2015.. 2015. |
| YIP K.H.R., Au Y.K., Yang W., Cheung M.C.H., Chan D. and Cheah K.S.E., Towards Understanding Genetic and Molecular Etiology of Campomelic Dysplasia., 19th Research Postgraduate Symposium Hong Kong Dec 10-11, 2014.. 2014. |
| Researcher : YU Y |
| List of Research Outputs |
| YU Y. and Tanner J.A., Highly selective DNA oligonucleotide aptamers against aggrecanase ADAMTS5 for degenerative disc disease therapy., Oligo 2015 Oxford: Antisense and Therapeutic Nucleic Acids, Oxford University, United Kingdom (2015). 2015. |
| Researcher : Yan B |
| List of Research Outputs |
| Poon N.Y.E., Keung W.W.Y. and Yan B., Proteomic Analysis of Human Pluripotent Stem Cell–Derived, Fetal, and Adult Ventricular Cardiomyocytes Reveals Pathways Crucial for Cardiac Metabolism and MaturationCLINICAL PERSPECTIVE, Circulation: Cardiovascular Genetics. 2015, 8: 427-436. |
| Researcher : Yang J |
| Project Title: | Investigation of physiology and possible neuroprotective effect of the retinal microglia under normal and glaucoma conditions |
| Investigator(s): | Yang J, So KF, Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2008 |
| List of Research Outputs |
| Chan L.K., Yang J. and Irby D., Application of the One-Minute Preceptor Technique by Novice Teachers in the Gross Anatomy Laboratory, Anatomical Sciences Education. 2015. |
| Chan L.K., Yang J. and Irby D.M., Application of the one-minute preceptor technique by novice teachers in the gross anatomy laboratory, Anatomical Sciences Education. 2015, n/a-n/a. |
| Researcher : Yeung PKK |
| Project Title: | The Effectiveness of Vasopressin V1 receptor antagonist , SR49059, and V2 Receptor Anatongist, OPC-31260, on Cerebral Edema Formation in Endothelin-1-Overexpressed Mice |
| Investigator(s): | Yeung PKK, Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2008 |
| List of Research Outputs |
| Hung K.L., Yeung P.K.K., Lai K.W., Lo A.C.Y., Chan C.K., Wu E.X., Chung S.M. and Chung S.K., Selective astrocytic endothelin-1 overexpression contributes to dementia associated with ischemic stroke by exaggerating astrocyte-derived amyloid secretion, In: Victor KL Hung1, Patrick KK Yeung1,2, Angela KW Lai1, Maggie CY Ho1, Amy CY Lo1,8, Kevin C Chan3,9, Ed XK Wu3, Stephen SM Chung4,10, Chi W Cheung5,6 and Sookja K Chung1,2,6,7, Journal of Cerebral Blood Flow & Metabolism. 2015. |
| LIU J., Yeung P.K.K., Cheng L., Lo A.C.Y., Chung S.M. and Chung S.K., Epac2-deficiency leads to more severe retinal swelling, glial reactivity and oxidative stress in transient middle cerebral artery occlusion induced ischemic retinopathy, In: LIU Jin, YEUNG Patrick Ka Kit, CHENG Lu, LO Amy Cheuk Yin,CHUNG Stephen Sum Man & CHUNG Sookja Kim, Science China Life Sciences. 2015. |
| Researcher : Yip MS |
| List of Research Outputs |
| Li Y., Kao P., Yip M.S., Sze K.L., Fosang A., McCulloch D., Cheung K.M.C., Samartzis D., Luk K.D.K., Karppinen J., Song Y., Cheah K.S.E., Sham P.C. and Chan D., Association and functional analysis of ADAMTS5 in lumbar disc degeneration, 42nd International Society for the Study of the Lumbar Spine. San Francisco. June 8-12, 2015.. 2015. |
| Researcher : Yip YL |
| Project Title: | Establishment and characterization of representative nasopharyngeal carcinoma cell lines |
| Investigator(s): | Yip YL, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2014 |
| List of Research Outputs |
| Jia L.J., Tsang C.M., Yip Y.L., Law W.T., Zhang J. and Tsao G.S.W., Establishment and characterization of immortalized nasopharyngeal epithelial cells with stable infection of Epstein-Barr virus, AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. 2015. |
| Lin W.T., Yip Y.L. and Tsao G.S.W., Cancer-Associated Fibroblasts Support Tumour Growth in Nasopharyngeal Carcinoma, Cell Symposia - Cancer, Inflammation, and Immunity. 2015. |
| Researcher : Yu C |
| Project Title: | Down-regulation of integrin-beta3 by clathrin-mediated endocytosis |
| Investigator(s): | Yu C |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 11/2014 |
| Project Title: | 2014 The American Society for Cell Biology Annual Meeting; Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force |
| Investigator(s): | Yu C |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 12/2014 |
| Completion Date: | 12/2014 |
| List of Research Outputs |
| Wu J., Liu Y., Guo Y., Feng S., Zou B., Mao H., Yu C., Tian D., Huang W. and Huo F., Centimeter-Scale Subwavelength Photolithography Using Metal-Coated Elastomeric Photomasks with Modulated Light Intensity at the Oblique Sidewalls, Langmuir. 2015, 31: 5005-5013. |
| Yu C., Microenvironment modulates adhesion transformation, PI3K signaling, and invadosome formation, Seminar in Department of Biology and Chemistry and Centre for Biosystems, Neuroscience, and Nanotechnology (CBNN), City University of Hong Kong . 2015. |
| Yu C., Spatial-temporal regulation of integrin activation, PI3K signaling, and podosome formation, Seminar, Division of Life Science, Hong Kong University of Science and Technology . 2015. |
| Researcher : Yuen KS |
| List of Research Outputs |
| Jin D., Tang H.M.V., GAO W., Chan C.P. and Yuen K.S., Retroviral oncoprotein Tax-induced activation of LKB1-SIK and SIRT1 signaling in the regulation of HTLV-1 transcription, The 15th International Symposium of the Society of Chinese Bioscientists in America. 2015. |
| Researcher : ZHANG Y |
| List of Research Outputs |
| XIONG C., Li Y., Muhammad, F.R., ., Sandell L., Chan W.C.W., Tam V., ZHANG Y., Song Y. and Cheah K.S.E., Sham P.C., Chan D., Understanding the genetic contribution to endogenous self-protective potentials of intervertebral disc., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.. 2015. |
| ZHANG Y., Song Y., Samartzis D., Bow C., Cheah K.S.E., Cheung M.C.H., Sham P.C., Chan D. and Leung K.K.H., Genetic risks for chronic periodontitis: preliminary data of a genome-wide association study., International Association for Dental Research Pan European Region Congress. Dubrovnik, Croatia. September 10-13, 2014.. 2014. |
| ZHANG Y., Chan W.C.W., Sakai D. and Chan D., Roles of Progenitors cells for Intervertebral Disc Regeneration in “Healer” mice., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.. 2015. |
| Researcher : ZHENG F |
| List of Research Outputs |
| LI T., ZHENG F., Cheung M.C.H., Wang F.S. and Fu C., Fission yeast mitochondria are distributed by dynamic microtubules in a motor-independent manner, Scientific Reports. Nature Publishing Group, 2015, 5: 1-10. |
| Researcher : ZHU S |
| List of Research Outputs |
| ZHU S., XU W., Li N.F. and Chen J., Effects of transepithelial bicarbonate transport in bacterial killing on the surface of cultured pig tracheal epithelia, The 10th International Symposium on Healthy Aging, Hong Kong. 2015. |
| Researcher : Zhou Z |
| Project Title: | Understanding the regulation of MT1-MMP activity in tumorigenesis |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Matching Fund for NSFC Young Researcher Award |
| Start Date: | 05/2006 |
| Project Title: | Screening anti-ageing substances in small chemical library using premature ageing animals |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 09/2007 |
| Project Title: | Ageing and longevity: biology and challenge |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Croucher Advanced Study Institute |
| Start Date: | 02/2009 |
| Project Title: | Stem Cells and the Key signaling Pathways in Bone Aging and Regeneration |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Matching Fund for National Key Basic Research Development Scheme (973 Projects) |
| Start Date: | 03/2011 |
| Project Title: | Stem Cell Strategy for Nervous System Disorders |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 09/2012 |
| Project Title: | MT1-MMP regulates neural stem cells self-renewal and differentiation via Notch signaling |
| Investigator(s): | Zhou Z, Osorio Da Silva LA |
| Department: | Biochemistry |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2013 |
| Project Title: | MT1-MMP-mediated ADAM15 shedding in angiogenesis |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2013 |
| Project Title: | Novel SIRT1 activator |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 06/2013 |
| Project Title: | Chromatin remodeling in laminopathy-based progeria |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 07/2013 |
| Project Title: | Interplay between ADAM15 and MT1-MMP in FGF2-induced angiogenesis |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2013 |
| Project Title: | Regulation of Gli Signaling and Basal Cell Carcinoma by UHRF1 |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 02/2014 |
| Project Title: | Regulation of heterochromatin remodeling in DNA repair and aging |
| Investigator(s): | Zhou Z, Hao Q, Chu IK |
| Department: | Biochemistry |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 02/2014 |
| Project Title: | Outstanding Researcher Award 2013-14 |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Outstanding Researcher Award |
| Start Date: | 12/2014 |
| List of Research Outputs |
| CUI H., LIU X., McCORMICK M., WASCKO B., ZHAO W., HE X., YUAN Y., FANG B., SUN X., KENNEDY B., SUH Y., Zhou Z., KAEBERLEIN M. and FENG W., PMT1 deficiency enhances basal UPR activity and extends replicative lifespan of Saccharomyces cerevisiae, AGE. 2015, 37. |
| Ghosh S. and Zhou Z., SIRTain regulators of premature senescence and accelerated aging., In: ZIHE RAO, Protein Cell. SPRINGER/Higher Education Press, 2015, 6: 322-333. |
| ZHAO W., ZHENG H., NIU Y., YUAN Y., FANG B., LIU Y., CAI L., Zhou Z. and LIU X., CIA2 deficiency results in impaired oxidative stress response and enhanced intracellular basal UPR activity in Saccharomyces cerevisiae, FEMS Microbiology Letters. 2015, 362: fnv013-fnv013. |
| Zhou Z., Associate Editor, Mutation Research. 2015. |
| Zhou Z., University Outstanding Research Award 2013/14, The University of Hong Kong. 2015. |