CENTRE FOR GENOMIC SCIENCES
| Researcher : Bao Y |
| List of Research Outputs |
| Gui H., Bao Y., Tang S.M., So M.T., Ngo D.N., Tran A.Q., Bui D.H., Pham D.H., Nguyen T.L., Tong A.H.Y., Lok S., Sham P.C., Tam P.K.H., Cherny S.S. and Garcia-Barcelo M.M., Targeted next-generation sequencing on Hirschsprung disease: a pilot study exploits DNA pooling, Annals of Human Genetics. 2014, 78(5): 381-387. |
| Researcher : Geng X |
| Project Title: | HKU Overseas Fellowship Awards 2013-14 |
| Investigator(s): | Geng X |
| Department: | School of Humanities |
| Source(s) of Funding: | HKU Overseas Fellowship Awards |
| Start Date: | 06/2013 |
| Completion Date: | 08/2014 |
| Project Title: | Novel Fast MRI Acquisition Technique and Its Application in Brain Functional Mapping and Connectivity Analyses |
| Investigator(s): | Geng X, Tan L |
| Department: | School of Humanities |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2013 |
| List of Research Outputs |
| Geng X., Hu Y., Gu H., Salmeron B.J., Stein E. and Yang Y., Cortical thickness in cocaine users: relationship to resting functional connectivity and cocaine use, 21st Annul Meeting of the Organization for Human Brain Mapping. 2015. |
| Researcher : Gui H |
| Project Title: | Identification for epilepsy-schizophrenia genetic sharing through multiple data mining approaches |
| Investigator(s): | Gui H, Cherny SS, Li M, Sham PC |
| Department: | Centre for Genomic Sciences |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2015 |
| List of Research Outputs |
| Gui H., Jiang C., Cherny S.S., Sham P.C., Xu L., Liu B., Jin Y.L., Zhu T., Zhang W., Thomas G.N., Cheng K.K. and Lam T.H., Influence of Alzheimer's disease genes on cognitive decline: the Guangzhou Biobank Cohort Study, Neurobiology of Aging. 2014, 35: 2422.e3–2422.e8. |
| Gui H., Tang S.M., Tam P.K.H. and Garcia-Barcelo M.M., Integrative genomic profile for a patient with Hirschsprung disease, The 2nd IRDiRC (International Rare Diseases Research Consortium) Conference, Shenzhen, China, 7-9 November, 2014. |
| Researcher : Lin C |
| List of Research Outputs |
| GAO X., Lin C., Kwan T.K., Lee V.H.F., Chan S.H., Sihoe D.L.A., Au S.K., Tin P.C., XIAO Z., Yam J.W.P., Wang J.J., Sham P.C. and Wong M.P., Application of whole exome sequencing in metachronous lung cancers evaluation, European Association for Cancer Research, Cambridge. 2015. |
| Li Y., Chan H.M., Chen L., Chow K.K., Guan X., Liu M. and Lin C., Faculty Outstanding Research Output, Faculty of Medicine, The University of Hong Kong. 2014. |
| Tong M., Fung T.M., Luk T.C.S., Ng K.Y., Lee K.W., Lin C., Yam J.W.P., Chan K.W., Ng F., Zheng B., Yuan Y.F., Xie D., Lo C.M., Man K., Guan X. and Ma S.K.Y., ANXA3/JNK Signaling Promotes Self-Renewal and Tumor Growth, and Its Blockade Provides a Therapeutic Target for Hepatocellular Carcinoma, Stem Cell Reports. 2015. |
| Researcher : Lok S |
| Project Title: | Generation of ferret (Mustela putorius furo) genomic resources for respiratory infectious disease research: Transcriptomics and comprehensive characterization of cDNAs in a model of influenza infection |
| Investigator(s): | Lok S, Tong AHY, Lee MY |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 04/2011 |
| List of Research Outputs |
| Gui H., Bao Y., Tang S.M., So M.T., Ngo D.N., Tran A.Q., Bui D.H., Pham D.H., Nguyen T.L., Tong A.H.Y., Lok S., Sham P.C., Tam P.K.H., Cherny S.S. and Garcia-Barcelo M.M., Targeted next-generation sequencing on Hirschsprung disease: a pilot study exploits DNA pooling, Annals of Human Genetics. 2014, 78(5): 381-387. |
| Researcher : Mak SHT |
| Project Title: | THE 2015 INTERNATIONAL WORKSHOP ON STATISTICAL GENETIC METHODS FOR HUMAN COMPLEX TRAITS; An improved polygenic score for prediction in genome-wide association studies |
| Investigator(s): | Mak SHT |
| Department: | Centre for Genomic Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2015 |
| List of Research Outputs |
| Mak S.H.T., Best N.G. and Rushton L., Robust Bayesian sensitivity analysis for case-control studies with uncertain exposure misclassification probabilities, International Journal of Biostatistics. 2015. |
| Researcher : Sham PC |
| Project Title: | Replication study of susceptibility genes for colorectal cancer |
| Investigator(s): | Sham PC, Ho JWC, Cheng KK |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2007 |
| Project Title: | Partner State Key Laboratory of Brain and Cognitive Sciences |
| Investigator(s): | Sham PC, So KF, Tan L |
| Department: | Centre for Genomic Sciences |
| Source(s) of Funding: | Matching Fund for State Key Laboratory (SKL) |
| Start Date: | 10/2008 |
| Project Title: | Visiting Research Professors Scheme 2009-10 |
| Investigator(s): | Sham PC |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Visiting Research Professors Scheme |
| Start Date: | 09/2009 |
| Project Title: | To determine the functional variants of candidate genes identified by Genome-wide Association Study of Osteoporosis |
| Investigator(s): | Sham PC, Gao RY, Xiao S, Kung AWC |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 07/2010 |
| Project Title: | Method and Software for Personal Risk Profiling of Complex Diseases |
| Investigator(s): | Sham PC, Cherny SS, Garcia-Barcelo MM, Kung AWC, Li M, Yang W |
| Department: | Psychiatry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2012 |
| Project Title: | Bioinformatics tools for identifying disease loci from exome sequencing data |
| Investigator(s): | Sham PC, Cherny SS, Garcia-Barcelo MM, Li M, Yang W |
| Department: | Psychiatry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Project Title: | Genomics |
| Investigator(s): | Sham PC, Chin FYL, Leung FCC |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 06/2013 |
| Project Title: | Cross Cultural Differences in Biased Cognition |
| Investigator(s): | Sham PC, Chen EYH, Toulopoulou T |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | ESRC/RGC Joint Research Scheme |
| Start Date: | 09/2013 |
| Project Title: | Statistical methods for characterizing the genetic component of polygenic diseases |
| Investigator(s): | Sham PC, Cherny SS |
| Department: | Psychiatry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Mutational spectrum for dilated cardiomyopathy in Hong Kong |
| Investigator(s): | Sham PC, Tse HF, Cherny SS, Garcia-Barcelo MM, Tang SM, Li M |
| Department: | Centre for Genomic Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2014 |
| Project Title: | Schizophrenia-related de novo and compound heterozygous mutations |
| Investigator(s): | Sham PC, Chen EYH, Chang WC, Chan KW, Lee HME, Cherny SS, Li M |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2015 |
| List of Research Outputs |
| Campbell D.D., PORSCH R.M., Cherny S.S., Capra V., Merello E., De Marco P., Sham P.C. and Garcia-Barcelo M.M., Cost effective assay choice for rare disease study designs, Orphanet Journal of Rare Diseases. 2015, 10. |
| Cherny S.S., WONG K.L., Sham P.C., Baum L.W. and Kwan P., Exome sequencing of mesial temporal lobe epilepsy with hippocampal sclerosis in parent-offspring trios, 2014 Annual Meeting of the American Society of Human Genetics. 2014. |
| Cheung J.P.Y., Samartzis D., Kao P., Shigematsu P., Cheah K.S.E., Song Y., Sham P.C., Chan D. and Cheung K.M.C., Developmental lumbar spinal stenosis in Southern Chinese: findings from a genome-wide association study., Combined Academic Conference of the 18th Biennial Congress of the Asia Pacific Orthopaedic Association and the 36th Annual Meeting of the Royal College of Orthopaedic Surgeons of Thailand. Pattaya, Thailand. October 23-25, 2014.. 2014. |
| GAO X., Lin C., Kwan T.K., Lee V.H.F., Chan S.H., Sihoe D.L.A., Au S.K., Tin P.C., XIAO Z., Yam J.W.P., Wang J.J., Sham P.C. and Wong M.P., Application of whole exome sequencing in metachronous lung cancers evaluation, European Association for Cancer Research, Cambridge. 2015. |
| Gui H., Jiang C., Cherny S.S., Sham P.C., Xu L., Liu B., Jin Y.L., Zhu T., Zhang W., Thomas G.N., Cheng K.K. and Lam T.H., Influence of Alzheimer's disease genes on cognitive decline: the Guangzhou Biobank Cohort Study, Neurobiology of Aging. 2014, 35: 2422.e3–2422.e8. |
| HUANG Y., Yang J., Ying D., Zhang Y., Shotelersuk V., Hirankarn N., Sham P.C., Lau Y.L. and Yang W., HLAreporter: a tool for HLA typing from next generation sequencing data, Genome Medicine. 2015, 7(1): 25. |
| Kwan S.H., Hsu Y.H., Cheung C.L., Dupuis J., Saint-Pierre A., Eriksson J., Handelman S.K., Aragaki A., Karasik D., Pramstaller P.P., Kooperberg C., Lacroix A.Z., Larson M.G., Lau K.S., Lorentzon M., Pichler I., Sham P.C., Taliun D., Vandenput L. and Kiel D.P., Meta-analysis Of Genome-wide Association Studies Identifies Two Loci Associated With Circulating Osteoprotegerin Levels., Hum Mol Genet. 2014. |
| Kwok H., Wu C.W., Palser A.L., Kellam P., Sham P.C., Kwong D.L.W. and Chiang A.K.S., Genomic diversity of Epstein-Barr virus genomes isolated from primary nasopharyngeal carcinoma biopsy samples, In: Kwok H, Wu CW, Palser AL, Kellam P, Sham PC, Kwong DL, Chiang AKS, Journal of Virology. 2014, 88(18):10662: DOI:10.1128/JVI.01665-14. |
| LI J., Deng S.J., WANG P., Yang W., Ho S.L., Sham P.C., Wang J.J. and Li M., wKGGSeq: A Comprehensive Strategy-Based and Disease-Targeted Online Framework to Facilitate Exome Sequencing Studies of Inherited Disorders, Human Mutation. 2015, 36: 496-503. |
| Lam L.C.W., WONG S.M., Wang M.J., Chan W.C., Chen E.Y.H., Ng M.K., Hung S.F., Cheung E.F.C., Sham P.C. and Chiu H.F.K., Prevalence, psychosocial correlates and service utilization of depressive and anxiety disorders in Hong Kong: the Hong Kong Mental Morbidity Survey (HKMMS), Social Psychiatry and Psychiatric Epidemiology. 2015. |
| Li M.J., Liu Z., Wang P., Wong M.P., Yeager M., Sham P.C., Chanock S.J., Xia Z. and Wang J.J., A Comprehensive Database for GWAS ¬identified Human Genetic Variants: An Update of GWASdb, The 2015 American College of Medical Genetics and Genomics (ACMG) Annual Clinical Genetics Meeting, Salt Lake City, US, 24-28 Mar 2015.. 2015. |
| Li M.L., Yan B., Sham P.C. and Wang J.J., Exploring the function of genetic variants in the non-coding genomic regions: approaches for identifying human regulatory variants affecting gene expression, Briefings in Bioinformatics. UK, Oxford Journal, 2015, 16: 393-412. |
| Li M.L., Wang L.Y., Sham P.C., Zhang M.Q., Liu S.J. and Wang J.J., Exploring the genome-wide roles of transcription factors and their complexes in chromosome interaction, The 64th American Society of Human Genetics Annual Meeting, San Diego, US, October 18–22, 2014.. 2014. |
| Li Y., Samartzis D., Campbell D., Cherny S.S., Cheung K.M.C., Luk K.D.K., Karppinen J., Song Y., Cheah K.S.E., Sham P.C. and Chan D., A novel pathway associated with lumbar disc degeneration: a genome-wide association study., 42nd International Society for the Study of the Lumbar Spine. San Francisco. June 8-12, 2015.. 2015. |
| Li Y., Kao P., Yip M.S., Sze K.L., Fosang A., McCulloch D., Cheung K.M.C., Samartzis D., Luk K.D.K., Karppinen J., Song Y., Cheah K.S.E., Sham P.C. and Chan D., Association and functional analysis of ADAMTS5 in lumbar disc degeneration, 42nd International Society for the Study of the Lumbar Spine. San Francisco. June 8-12, 2015.. 2015. |
| Nelson M.R., Tipney H., Painter J.L., Shen J., Nicoletti P., Shen Y., Floratos A., Sham P.C., LI J., Wang J.J., Cardon L.R., Whittaker J.C. and Sanseau P., The support of human genetic evidence for approved drug indications, Nature Genetics. 2015. |
| XIONG C., Li Y., Muhammad, F.R., ., Sandell L., Chan W.C.W., Tam V., ZHANG Y., Song Y. and Cheah K.S.E., Sham P.C., Chan D., Understanding the genetic contribution to endogenous self-protective potentials of intervertebral disc., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.. 2015. |
| Ying D., Sham P.C., Smith D.K., ZHANG L., Lau Y.L. and Yang W., HaploShare: identification of extended haplotypes shared by cases and evaluation against controls, Genome Biology. 2015, 16: 92. |
| ZHANG Y., Song Y., Samartzis D., Bow C., Cheah K.S.E., Cheung M.C.H., Sham P.C., Chan D. and Leung K.K.H., Genetic risks for chronic periodontitis: preliminary data of a genome-wide association study., International Association for Dental Research Pan European Region Congress. Dubrovnik, Croatia. September 10-13, 2014.. 2014. |
| ZHANG Y., Yang J., ZHANG J., Sun L., Hirankarn N., Pan H.F., Lau W.C.S., Chan T.M., Lee T.L., Leung A.M., Mok C.C., ZHANG L., WANG Y., Shen J.J., Wong S.N., Lee K.W., Ho M.H.K., Lee P.P.W., Chung B.H.Y., Chong C.Y., Wong R.W.S., Mok T.M.Y., Wong W.H.S., Tong K.L., Tse N.K.C., LI X.P., Avihingsanon Y., Rianthavorn P., SDeekajorndej T., Shotelersuk V., Suphapeetiporn K., Shotelersuk V., Ying S.K.Y., Fung S.K.S., Lai W.M., Wong C.M., Ng I.O.L., Sham P.C., Garcia-Barcelo M.M., Cherny S.S., Cui Y., Sham P.C., Yang S., Ye D.Q., Zhang X.J., Lau Y.L. and Yang W., Genome-wide search followed by replication reveals genetic interaction of CD80 and ALOX5AP associated with systemic lupus erythematosus in Asian populations, Annuals of Rheumatic Diseases. 2015. |
| Zhang Y., Wang Y., Yang J., ZHANG J., Sun L., Hirankarn N., Pan C.F., Lau W.C.S., Chan T.M., Lee T.L., Leung A.M.H., Mok C.C., ZHANG L., SHEN J., Wong S.N., Lee K.W., Ho M.H.K., Lee P.P.W., Chung B.H.Y., Chong C.Y., Wong R.W.S., Mok T.M.Y., Wong W.H.S., Tong K.L., Tse N.K., Li X.P., Avihingsanon Y., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Shotelersuk V., Ying S.K., Fung S.K., Lai W.M., Wong C.M., Ng I.O.L., Garcia-Barcelo M.M., Cherny S.S., Tam P.K.H., Sham P.C., Yang S., Ye D.Q., Cui Y., Zhang X.J., Yang W. and Lau Y.L., Meta-analysis of two Chinese populations identifies an autoimmune disease risk allele in 22q11.21 as associated with systemic lupus erythematosus, Arthritis Research & Therapy. 2015, 17: 67. |
| Researcher : Tong AHY |
| List of Research Outputs |
| Gui H., Bao Y., Tang S.M., So M.T., Ngo D.N., Tran A.Q., Bui D.H., Pham D.H., Nguyen T.L., Tong A.H.Y., Lok S., Sham P.C., Tam P.K.H., Cherny S.S. and Garcia-Barcelo M.M., Targeted next-generation sequencing on Hirschsprung disease: a pilot study exploits DNA pooling, Annals of Human Genetics. 2014, 78(5): 381-387. |
| Researcher : Wang JJ |
| Project Title: | Understanding the co-evolutionary relationship between transcription factors and their DNA binding sites for bHLH family in eukaryotes |
| Investigator(s): | Wang JJ, Yao KM |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2011 |
| Completion Date: | 08/2014 |
| Project Title: | Outstanding Young Researcher Award 2011-12 |
| Investigator(s): | Wang JJ |
| Department: | Biochemistry |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 01/2013 |
| Project Title: | A computational framework to infer regulatory modules from integrative analysis of ChIP-seq and transcriptome data |
| Investigator(s): | Wang JJ |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2013 |
| Project Title: | Design of versatile super promoters for highly efficient mammalian gene expression |
| Investigator(s): | Wang JJ, Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 06/2013 |
| Completion Date: | 05/2015 |
| Project Title: | ISMB/ECCB 2013; Genetic variants in the next generation: detection, reprioritizing and function annotation |
| Investigator(s): | Wang JJ |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2013 |
| Project Title: | A computational algorithm to identify regulators for regulatory genetic variants in cancer genomics |
| Investigator(s): | Wang JJ |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2014 |
| Project Title: | A novel computational framework to identify transcription factor-DNA interaction for cancer genomics |
| Investigator(s): | Wang JJ, Yao KM, Wong MP |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 08/2014 |
| Project Title: | 248th ACS National Meeting & Exposition; Decoding genetic and epigenetic networks for vitamin C mediated cell reprogramming |
| Investigator(s): | Wang JJ |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2014 |
| Completion Date: | 08/2014 |
| Project Title: | Understanding the effects of DNA methylation on gene expression - a computational approach |
| Investigator(s): | Wang JJ, Wong MP, Chim JCS |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2015 |
| List of Research Outputs |
| Gan J., Wang C., Jin Y., Guo Y., XU F., Zhu Q., Ding L., Shang H., Wang J.J., Wei F., Cai Q. and Robertson E.S., Proteomic profiling identifies the SIM-associated complex of KSHV-encoded LANA, PROTEOMICS. 2015, 15: 2023-2037. |
| Guan D., Boheler K.R., Wang J.J. and Yan B., PTHGRN: unraveling post-translational hierarchical gene regulatory networks using PPI, ChIP-seq and gene expression data, Nucleic Acids Research. UK, Oxford Journal, 2014, 12: W131-136. |
| Hu J., Zhao Z., Yalamanchili H.K., Wang J.J., Ye K. and Fan X., Bayesian detection of embryonic gene expression onset in C. elegans, The Annals of Applied Statistics. 2015, 9: 950-968. |
| LI J. and Wang J.J., Current trend of annotating single nucleotide variation in humans – A case study on SNVrap, Methods. 2015, 79-80: 32-40. |
| LI J., Deng S.J., WANG P., Yang W., Ho S.L., Sham P.C., Wang J.J. and Li M., wKGGSeq: A Comprehensive Strategy-Based and Disease-Targeted Online Framework to Facilitate Exome Sequencing Studies of Inherited Disorders, Human Mutation. 2015, 36: 496-503. |
| Li M.J., Wu J., Chen Y., Li W., Jiang P., Zhu Y., Wang J.J., Liu J. and Liu X.S., Exploring functional variation affecting miRNA and ceRNA regulation in human, The Program in Quantitative Genomics 2014, Integrative Approaches to Understand Allelic Function, Boston, US, November 20-21, 2014.. 2014. |
| Li M.L., Yan B., Sham P.C. and Wang J.J., Exploring the function of genetic variants in the non-coding genomic regions: approaches for identifying human regulatory variants affecting gene expression, Briefings in Bioinformatics. UK, Oxford Journal, 2015, 16: 393-412. |
| Li M.L., Wang L.Y., Sham P.C., Zhang M.Q., Liu S.J. and Wang J.J., Exploring the genome-wide roles of transcription factors and their complexes in chromosome interaction, The 64th American Society of Human Genetics Annual Meeting, San Diego, US, October 18–22, 2014.. 2014. |
| Nelson M.R., Tipney H., Painter J.L., Shen J., Nicoletti P., Shen Y., Floratos A., Sham P.C., LI J., Wang J.J., Cardon L.R., Whittaker J.C. and Sanseau P., The support of human genetic evidence for approved drug indications, Nature Genetics. 2015. |
| QIN Y., YALAMANCHILI H.K., Qin J., Yan B. and Wang J.J., The Current Status and Challenges in Computational Analysis of Genomic Big Data, Big Data Research. 2015, 2: 12-18. |
| WANG P., Qin J., QIN Y., ZHU Y., WANG Y., LI J., Zhang M.Q. and Wang J.J., ChIP-Array 2: integrating multiple omics data to construct gene regulatory networks, Nucleic Acids Research. 2015, 43(W1): W264-9. |
| Wang P., Li M.J., Liu X. and Wang J.J., MapIn: an Interactive Mapping tool for biological descriptors, International Conference on Systems Biology 2014, Qingdao, China, 24-27 October, 2014.. 2014. |
| Wang Z., Zhu B., Zhang M., Parikh H., Wong M.P., Xu J. and Wang J.J., Imputation and subset based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33., In: Z. Wang, B. Zhu, M. Zhang, M. P. Wong, J. Wang, J, Xu and 205 editors, Hum Mol Genet . 2014, 23(24): 6616-33. |