DEPT OF CLINICAL ONCOLOGY



Researcher : CHOW KK

List of Research Outputs

Li Y., Chan H.M., Chen L., Chow K.K., Guan X., Liu M. and Lin C., Faculty Outstanding Research Output, Faculty of Medicine, The University of Hong Kong. 2014.
SONG Y., Pan G., Chen L., Ma S.K.Y., Zeng T., Chan T.H., Li L., Lian Q., CHOW K.K., Cai X., Li Y., Li Y., Liu M., LI Y., Zhu Y., Wong N., Yuan Y.F., Pei D. and Guan X., Loss of ATOH8 increases stem cell features of hepatocellular carcinoma cells, Gastroenterology. 2015.


Researcher : Chan HM

List of Research Outputs

Li Y., Chan H.M., Chen L., Chow K.K., Guan X., Liu M. and Lin C., Faculty Outstanding Research Output, Faculty of Medicine, The University of Hong Kong. 2014.


Researcher : Chan OSH

List of Research Outputs

Lee W.M.A., Ngan K.C., Tung S.Y., Cheng A., Kwong D.L.W., Lu T.X., Chan A.T.C., Chan L.L.K., Yiu H., Ng W.T., Wong F., Yuen K.T., Yau S., Cheung F.Y., Chan O.S.H., Choi H. and Chappell R., Preliminary results of trial NPC-0501 evaluating the therapeutic gain by changing from concurrent-adjuvant to induction-concurrent chemoradiotherapy, changing from fluorouracil to capecitabine, and changing from conventional to accelerated radiotherapy fr, Cancer. 2015, 121: 1328-1338.
Sze C.K.H., Chan L.L.K., Ng W.T., Hung A.W.M., Lee M.C.H., Chang A.T.Y., Chan O.S.H., Cheung F.Y., Yeung M.W.R. and Lee W.M.A., Should all nasopharyngeal carcinoma with masticator space involvement be staged as T4?, Oral Oncology. 2014, 50.


Researcher : Chen L

List of Research Outputs

Guan X., Chen L., Ma S.K.Y., Li Y. and Liu M., Molecular mechanisms of development and progression of hepatocellular carcinoma, Science and Technology Prize of Higher Education of China (Natural Science, Second-class). 2014.
Li Y., Chan H.M., Chen L., Chow K.K., Guan X., Liu M. and Lin C., Faculty Outstanding Research Output, Faculty of Medicine, The University of Hong Kong. 2014.
WANG J., Liu M., Chen L., JIANG L., Yuan Y.F. and Guan X., Overexpression of N-terminal kinase like gene promotes tumorigenicity of hepatocellular carcinoma by regulating cell cycle progression and cell motility, Oncotarget. 2015, 6(3): 1618-1630.


Researcher : Cheng CK

List of Research Outputs

Cheng S.C., Wu V.W.C., Kwong D.L.W., Lui C.Y., Cheng C.K., Kot B.C. and Ying M.T., Sonographic appearance of thyroid glands in patients treated with intensity-modulated radiotherapy or conventional radiotherapy for nasopharyngeal carcinoma , Journal of Clinical Ultrasound . 2014 Wiley Periodicals, Inc., 2014.


Researcher : Cheng Y

Project Title:A novel tumor suppressive pathway mediated by BLU gene in nasopharyngeal carcinoma
Investigator(s):Cheng Y, Lung ML
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:11/2012
Completion Date:01/2015


List of Research Outputs

Cheng Y., Ho R.L.K.Y., Chan K.C., Kan R.J.A., Tung E., Lung H.L., Yau W.L., Cheung A.K.L., Ko J.M.Y., Zhang Z.F., Luo D.Z., Feng Z.B., Chen S., Guan X., Kwong D.L.W., Stanbridge E.J. and Lung M.L., Anti-angiogenic pathway associations of the 3p21.3 mapped BLU gene in nasopharyngeal carcinoma, Oncogene. 2014.
Cheng Y., Phoon Y.P., Jin X., Chong S.Y.S., Ip J.C.Y., Wong W.Y. and Lung M.L., Wnt-C59 arrests stemness and suppresses growth of nasopharyngeal carcinoma in mice by inhibiting the Wnt pathway in the tumor microenvironment, Oncotarget. 2015, 6: 14428-39.
Cheung A.K.L., Ip J.C.Y., Chu C.H.A., Cheng Y., Leong M.L., Ko J.M.Y., Shuen W.H., Lung H.L. and Lung M.L., PTPRG suppresses tumor growth and invasion via inhibition of Akt signaling in nasopharyngeal carcinoma, Oncotarget. 2015, 6: 13434-47.
Dai W., Cheung A.K.L., Ko J.M.Y., Cheng Y., ZHENG H., Kwong D.L.W., Ngan R., Ng W.T., Lee A.W.M., Yau C.C. and Lung M.L., Aberrant methylation at chromosome 6p as novel biomarkers for diagnosis and prognosis of nasopharyngeal carcinoma, 106th American Association of Cancer Research. Philadelphia, Pennsylvania, USA. 2015.
Dai W., Cheung A.K.L., Ko J.M.Y., Cheng Y., Zheng H., Ngan R., Ngan W.T., Lee A.W.M., Yau C.C., Lee V.H.F. and Lung M.L., Comparative methylome analysis in solid tumors reveals aberrant methylation at chromosome 6p in nasopharyngeal carcinoma, Cancer Medicine. 2015, n/a-n/a.
Lung M.L., Cheung A.K.L., Ko J.M.Y., Lung H.L., Cheng Y. and Dai W., The interplay of host genetic factors and Epstein-Barr virus in the development of nasopharyngeal carcinoma, Chinese Journal of Cancer. 2014, 33: 556-568.


Researcher : Cheung AKL

Project Title:Investigation of the role of Epstein-Barr Virus in epigenetic regulation in nasopharyngeal carcinoma
Investigator(s):Cheung AKL, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:01/2012


Project Title:Investigation of EBV-associated host cell histone modification and gene expression changes in nasopharyngeal carcinoma by next generation sequencing
Investigator(s):Cheung AKL, Lung ML, Tsao GSW
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:08/2013


Project Title:16th International symposium on EBV and associated diseases; Protein Tyrosine Phosphatase, Receptor Type G regulates Akt Signaling in Nasopharyngeal Carcinoma
Investigator(s):Cheung AKL
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:07/2014
Completion Date:07/2014


Project Title:Functional validation of a novel DUB3 somatic mutation in tumors of nasopharyngeal carcinoma
Investigator(s):Cheung AKL, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:01/2015


List of Research Outputs

Cheng Y., Ho R.L.K.Y., Chan K.C., Kan R.J.A., Tung E., Lung H.L., Yau W.L., Cheung A.K.L., Ko J.M.Y., Zhang Z.F., Luo D.Z., Feng Z.B., Chen S., Guan X., Kwong D.L.W., Stanbridge E.J. and Lung M.L., Anti-angiogenic pathway associations of the 3p21.3 mapped BLU gene in nasopharyngeal carcinoma, Oncogene. 2014.
Cheung A.K.L., Ip J.C.Y., Chu C.H.A., Cheng Y., Leong M.L., Ko J.M.Y., Shuen W.H., Lung H.L. and Lung M.L., PTPRG suppresses tumor growth and invasion via inhibition of Akt signaling in nasopharyngeal carcinoma, Oncotarget. 2015, 6: 13434-47.
Cheung A.K.L. and Lung M.L., Protein Tyrosine Phosphatase, Receptor Type G regulates Akt Signaling in Nasopharyngeal Carcinoma, 16th International Symposium on EBV and Associated Diseases. Brisbane, Australia. 2014.
Cheung A.K.L. and Lung M.L., Protein tyrosine phosphatase, receptor type G regulates tumorigenicity and invasion via AKT signaling in NPC, 7th International NPC Biannual Meeting. Yogyakarta, Indonesia. 2015.
Cheung A.K.L. and Lung M.L., Small Project Funding - “Functional validation of a novel DUB3 somatic mutation in tumors of NPC” HK$80,000, HKU University Research Committee. 2015.
Dai W., Cheung A.K.L., Ko J.M.Y., Cheng Y., ZHENG H., Kwong D.L.W., Ngan R., Ng W.T., Lee A.W.M., Yau C.C. and Lung M.L., Aberrant methylation at chromosome 6p as novel biomarkers for diagnosis and prognosis of nasopharyngeal carcinoma, 106th American Association of Cancer Research. Philadelphia, Pennsylvania, USA. 2015.
Dai W., Cheung A.K.L., Ko J.M.Y., Cheng Y., Zheng H., Ngan R., Ngan W.T., Lee A.W.M., Yau C.C., Lee V.H.F. and Lung M.L., Comparative methylome analysis in solid tumors reveals aberrant methylation at chromosome 6p in nasopharyngeal carcinoma, Cancer Medicine. 2015, n/a-n/a.
Dai W., ZHENG H., Tang S.M., Sham P.C., Ko J.M.Y., Cheung A.K.L. and Lung M.L., Using Next-generation Whole-Exome Sequencing Approaches to Elucidate the Genetic Basis for Nasopharyngeal Carcinoma , Gorden Research Conference Genomic Instability. 2014.
KAN P.Q.R., Shuen W.H., Lung H.L., Cheung A.K.L., Dai W., Kwong D.L.W., Ng W.T., Lee A.W.M., Yau C.C., Ngan R.K., Tung S. and Lung M.L., NF-κB p65 Subunit Is Modulated by Latent Transforming Growth Factor-β Binding Protein 2 (LTBP2) in Nasopharyngeal Carcinoma HONE1 and HK1 Cells, PLOS ONE. 2015, 10: e0127239.
Lung M.L., Cheung A.K.L., Ko J.M.Y., Lung H.L., Cheng Y. and Dai W., The interplay of host genetic factors and Epstein-Barr virus in the development of nasopharyngeal carcinoma, Chinese Journal of Cancer. 2014, 33: 556-568.
ZHENG H., Dai W., Tang S.M., Cheung A.K.L., Ko J.M.Y., Sham P.C. and Lung M.L., Unraveling the genetic basis of nasopharyngeal carcinoma using next-generation sequencing approaches, 106th American Association of Cancer Research. Philadelphia, Pennsylvania, USA. 2015.


Researcher : Cheung FY

List of Research Outputs

Lee W.M.A., Ngan K.C., Tung S.Y., Cheng A., Kwong D.L.W., Lu T.X., Chan A.T.C., Chan L.L.K., Yiu H., Ng W.T., Wong F., Yuen K.T., Yau S., Cheung F.Y., Chan O.S.H., Choi H. and Chappell R., Preliminary results of trial NPC-0501 evaluating the therapeutic gain by changing from concurrent-adjuvant to induction-concurrent chemoradiotherapy, changing from fluorouracil to capecitabine, and changing from conventional to accelerated radiotherapy fr, Cancer. 2015, 121: 1328-1338.
Sze C.K.H., Chan L.L.K., Ng W.T., Hung A.W.M., Lee M.C.H., Chang A.T.Y., Chan O.S.H., Cheung F.Y., Yeung M.W.R. and Lee W.M.A., Should all nasopharyngeal carcinoma with masticator space involvement be staged as T4?, Oral Oncology. 2014, 50.


Researcher : Chow KK

List of Research Outputs

Li Y., Chan H.M., Chen L., Chow K.K., Guan X., Liu M. and Lin C., Faculty Outstanding Research Output, Faculty of Medicine, The University of Hong Kong. 2014.
SONG Y., Pan G., Chen L., Ma S.K.Y., Zeng T., Chan T.H., Li L., Lian Q., CHOW K.K., Cai X., Li Y., Li Y., Liu M., LI Y., Zhu Y., Wong N., Yuan Y.F., Pei D. and Guan X., Loss of ATOH8 increases stem cell features of hepatocellular carcinoma cells, Gastroenterology. 2015.


Researcher : Choy TS

List of Research Outputs

Lam K.O., Cheung G., Sze C.K.H., Lee V.H.F., Tsang J.W.H., Choy T.S., Leung T.W. and Kwong D.L.W., The impact of complete metabolic response in the treatment of metastatic colorectal cancer, In: Annals of Oncology, 39th European Society for Medical Oncologist Congress. 2014.


Researcher : Chu CHA

List of Research Outputs

Cheung A.K.L., Ip J.C.Y., Chu C.H.A., Cheng Y., Leong M.L., Ko J.M.Y., Shuen W.H., Lung H.L. and Lung M.L., PTPRG suppresses tumor growth and invasion via inhibition of Akt signaling in nasopharyngeal carcinoma, Oncotarget. 2015, 6: 13434-47.


Researcher : Chua DTT

Project Title:2000 Annual Meeting of the American Society for Therapeutic Radiology and Oncology Patterns of Failure after Induction Chemotherapy and Radiotherapy for Loco-Regionally Advanced Nasopharyngeal Carcinoma: The Queen Mary Hospital Experience
Investigator(s):Chua DTT
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2000


Project Title:2001 Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology Control of Regional Metastasis after Induction Chemotherapy and Radiotherapy for Nasopharyngeal Carcinoma
Investigator(s):Chua DTT
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:11/2001


Project Title:The Radiological Society of North America 89th Scientific Assembly and Annual Meeting Prognostic Value of Tumor Volume in Early Stage Nasopharyngeal Carcinoma Treated by Radiotherapy
Investigator(s):Chua DTT
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:11/2003


Project Title:46th Annual Meeting of the American Society for Therapeutic Radiology and Oncology Prognostic Impact of Hemoglobin Level on Treatment Outcome in Patients with Nasopharyngeal Carcinoma Treated with Sequential Chemoradiotherapy or Radiotherapy Alone
Investigator(s):Chua DTT
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2004


Project Title:Nasopharyngeal Carcinoma (NPC)
Investigator(s):Chua DTT, Nicholls JM
Department:Clinical Oncology
Source(s) of Funding:Croucher Foundation - Research Grants
Start Date:01/2007




Researcher : Dai W

Project Title:Pilot Study for Deciphering Methylome of Nasopharyngeal Carcinoma (NPC)
Investigator(s):Dai W, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:05/2014
Completion Date:03/2015


Project Title:AACR Annual Meeting; Aberrant Methylation at Chromosome 6p as Novel Biomarkers for Diagnosis and Prognosis of Nasopharyngeal Carcinoma
Investigator(s):Dai W
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:04/2015


List of Research Outputs

Dai W., Cheung A.K.L., Ko J.M.Y., Cheng Y., ZHENG H., Kwong D.L.W., Ngan R., Ng W.T., Lee A.W.M., Yau C.C. and Lung M.L., Aberrant methylation at chromosome 6p as novel biomarkers for diagnosis and prognosis of nasopharyngeal carcinoma, 106th American Association of Cancer Research. Philadelphia, Pennsylvania, USA. 2015.
Dai W., Cheung A.K.L., Ko J.M.Y., Cheng Y., Zheng H., Ngan R., Ngan W.T., Lee A.W.M., Yau C.C., Lee V.H.F. and Lung M.L., Comparative methylome analysis in solid tumors reveals aberrant methylation at chromosome 6p in nasopharyngeal carcinoma, Cancer Medicine. 2015, n/a-n/a.
Dai W., ZHENG H., Tang S.M., Sham P.C., Ko J.M.Y., Cheung A.K.L. and Lung M.L., Using Next-generation Whole-Exome Sequencing Approaches to Elucidate the Genetic Basis for Nasopharyngeal Carcinoma , Gorden Research Conference Genomic Instability. 2014.
KAN P.Q.R., Shuen W.H., Lung H.L., Cheung A.K.L., Dai W., Kwong D.L.W., Ng W.T., Lee A.W.M., Yau C.C., Ngan R.K., Tung S. and Lung M.L., NF-κB p65 Subunit Is Modulated by Latent Transforming Growth Factor-β Binding Protein 2 (LTBP2) in Nasopharyngeal Carcinoma HONE1 and HK1 Cells, PLOS ONE. 2015, 10: e0127239.
Ko J.M.Y., Dai W., Wong E.H.W., Kwong D.L.W., Ng W.T., Lee A., Ngan R.K.C., Yau C.C., Tung S. and Lung M.L., Case-control association studies of DNA damage repair genes associated with genetic susceptibility of nasopharyngeal carcinoma , Gordon Research Conference Genomic Instability. 2014.
Ko J.M.Y., Dai W., Wong H.W.E., Kwong D.L.W., Ng W.T., Lee A.W.M., Ngan R.K., Yau C.C., Tung S. and Lung M.L., Cumulative effects of TERT-CLPTM1L and double-strand breaks repair contribute to higher risk for nasopharyngeal carcinoma, Gordon Research Conferences Genomic Instability Hong Kong. 2014.
Ko J.M.Y., Dai W., Kwong D.L.W., Ng W.T., Lee A.W.M., Ngan R.C., Yau C.C., Tung S. and Lung M.L., The genetic susceptibility and prognostic role of TERT-CLPTM1L and dnes in DNA damage pathways in NPC, 7th International NPC Biannual Meeting. Yogyakarta, Indonesia. 2015.
Lung M.L., Cheung A.K.L., Ko J.M.Y., Lung H.L., Cheng Y. and Dai W., The interplay of host genetic factors and Epstein-Barr virus in the development of nasopharyngeal carcinoma, Chinese Journal of Cancer. 2014, 33: 556-568.
YANG X., Dai W., Kwong D.L.W., Szeto C.Y.Y., Wong H.W.E., Ng W.T., Lee A.W.M., Ngan K.C., Yau C.C., Tung S.Y. and Lung M.L., Epigenetic markers for non-invasive early detection of nasopharyngeal carcinoma by methylation-sensitive high resolution melting, International Journal of Cancer. 2014.
ZHENG H., Dai W., Tang S.M., Cheung A.K.L., Ko J.M.Y., Sham P.C. and Lung M.L., Unraveling the genetic basis of nasopharyngeal carcinoma using next-generation sequencing approaches, 106th American Association of Cancer Research. Philadelphia, Pennsylvania, USA. 2015.


Researcher : Fong HL

List of Research Outputs

Seneviratne C.J., Fong H.L., Wong S.S.W. and Lee V.H.F., Antifungal susceptibility and phenotypic characterization of oral isolates of a black fungus from a nasopharyngeal carcinoma patient under radiotherapy, BMC oral health. 2015, 15.


Researcher : Fu L

List of Research Outputs

Jiang L., Yang Y.D., Fu L., Xu W., Liu D., Liang Q., Zhang X., Xu L., Guan X., Wu B., Sung J.J. and Yu J., CLDN3 inhibits cancer aggressiveness via Wnt-EMT signaling and is a potential prognostic biomarker for hepatocellular carcinoma, Oncotarget. 2014, 5(17): 7663-7676.


Researcher : Guan X

Project Title:49th Annual Meeting of the American Society of Human Genetics The Association of Chromosome 8p Deletion and Tumor Metastasis in Human Hepatocellular Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/1999


Project Title:51st Annual Meeting of the American Society of Human Genetics Loss of Tyrosine Aminotransferase may Contribute to the Development of Hepatocellular Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2001


Project Title:Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2009


Project Title:Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2009


Project Title:The Liver Cancer Genome Project: translating genetic discoveries to clinical benefits
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Theme-based Research Scheme
Start Date:12/2011


Project Title:A novel strategy for prevention and treatment of HIV-1 infection
Investigator(s):Guan X, Zhang M
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:12/2012


Project Title:Analysis of the role of ATOH8 and HCC cancer stem cell and somatic cell reprogramming
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2013


Project Title:Outstanding Researcher Award 2011-12
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Outstanding Researcher Award
Start Date:01/2013


Project Title:Characterization of CHD1L in regulating hepatocellular carcinoma stemness and self-renewal
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2013


Project Title:Cancer
Investigator(s):Guan X, Chan CLW, Tsao GSW
Department:Clinical Oncology
Source(s) of Funding:Seed Funding for Strategic Research Theme
Start Date:11/2013


Project Title:Characterization of the effect of Epstein-Barr Virus encoded BART microRNAs on enhancing tumor-initiating properties and potentially serve as biomarkers in Nasopharyngeal Carcinoma
Investigator(s):Guan X, Kwong DLW
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2014


Project Title:Characterization of the regulatory roles of CHD1L in stemness and differentiation in hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2014


Project Title:Characterization of tumor suppressive function of HBP21 in hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:06/2014


Project Title:Exploring the Mechanism for Cancer Associated Fibroblasts Recruitment and the Potential Therapeutic Value in Esophageal Squamous Cell Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2015


Project Title:Investigation of the role of Maelstrom in cancer stem cell reprogramming
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2015


Project Title:Investigation of effects and molecular mechanisms of FGFR2-positive cancer-associate fibroblasts on tumor microenvironment in esophageal squamous cell carcinoma
Investigator(s):Guan X, Chen Z, Ma SKY
Department:Clinical Oncology
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:04/2015


Project Title:Establishing an intracellular targeting antibody platform for cancer treatment
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:05/2015


List of Research Outputs

Cheng L., Tang X., Liu L., PENG J., Nishiura K., Cheung K.L.A., GUO J., WU X., Tang H., An M., ZHOU J., Cheung K.W., Wang H., Guan X., Wu Z. and Chen Z., Monoclonal antibodies specific to human Δ42PD1: A novel immunoregulator potentially involved in HIV-1 and tumor pathogenesis, mAbs. 2015, 7: 620-629.
Cheng Y., Ho R.L.K.Y., Chan K.C., Kan R.J.A., Tung E., Lung H.L., Yau W.L., Cheung A.K.L., Ko J.M.Y., Zhang Z.F., Luo D.Z., Feng Z.B., Chen S., Guan X., Kwong D.L.W., Stanbridge E.J. and Lung M.L., Anti-angiogenic pathway associations of the 3p21.3 mapped BLU gene in nasopharyngeal carcinoma, Oncogene. 2014.
Cheung A.N.Y., Guan X. and Ngan H.Y.S., Cervical cancer screening by enhanced cytology: application of novel markers, Hong Kong Med J. 2014.
Deng W., ZHOU Y., Tiwari A.F.Y., Su H., Yang J., ZHU D., LAU M.Y., Hau P.M., Yip Y.L., Cheung A., Guan X. and Tsao G.S.W., p21/Cyclin E pathway modulates anticlastogenic function of Bmi-1 in cancer cells., International Journal of Cancer. 2015, 136: 1361-1370.
Guan X., Chen L., Ma S.K.Y., Li Y. and Liu M., Molecular mechanisms of development and progression of hepatocellular carcinoma, Science and Technology Prize of Higher Education of China (Natural Science, Second-class). 2014.
Jiang L., Yang Y.D., Fu L., Xu W., Liu D., Liang Q., Zhang X., Xu L., Guan X., Wu B., Sung J.J. and Yu J., CLDN3 inhibits cancer aggressiveness via Wnt-EMT signaling and is a potential prognostic biomarker for hepatocellular carcinoma, Oncotarget. 2014, 5(17): 7663-7676.
Li B., XU W., Guan X., Law S.Y.K., Tsao G.S.W. and Cheung A., Suppression of esophageal tumor growth and chemoresistance by directly targeting the PI3K/AKT pathway, 2014 World Cancer Congress,December 3-6, Melbourne, Australia.. 2014, Abstract No. 1196.
Li B., Li J., Xu W., Guan X., Qin Y.R., Zhang L., Law S.Y.K., Tsao G.S.W. and Cheung A., Suppression of esophageal tumor growth and chemoresistance by directly targeting the PI3K/AKT pathway, Oncotarget. 2014, 5(22): 11576-11587.
Li J., Deng Z., Wang Z., Wang D., Zhang L., Su Q., Lai Y., Li B., Luo Z., Chen X., Chen Y., Huang X., Ma J., Wang W., Bi J. and Guan X., Zipper-interacting protein kinase promotes epithelial-mesenchymal transition, invasion and metastasis through AKT and NF-kB signaling and is associated with metastasis and poor prognosis in gastric cancer patients, Oncotarget. 2015, 6(10): 8323-8338.
Li Y., Chan H.M., Chen L., Chow K.K., Guan X., Liu M. and Lin C., Faculty Outstanding Research Output, Faculty of Medicine, The University of Hong Kong. 2014.
Liu M. and Guan X., Allele imbalance in the transcriptome of human hepatocellular carcinoma: stress-induced gene plays a role, Science Proceedings. 2014, 1: 1-2.
Liu M., JIANG L. and Guan X., The genetic and epigenetic alterations in human hepatocellular carcinoma: a recent update, Protein & Cell. 2014, 5: 673-691.
SONG Y., Pan G., Chen L., Ma S.K.Y., Zeng T., Chan T.H., Li L., Lian Q., CHOW K.K., Cai X., Li Y., Li Y., Liu M., LI Y., Zhu Y., Wong N., Yuan Y.F., Pei D. and Guan X., Loss of ATOH8 increases stem cell features of hepatocellular carcinoma cells, Gastroenterology. 2015.
Song Y., LI J., Zhu Y., Dai Y., Zeng T., Liu L., Li J., Wang H., Qin Y., Zeng M., Guan X. and Li Y., MicroRNA-9 promotes tumor metastasis via repressing E-cadherin in esophageal squamous cell carcinoma, Oncotarget. 2014, 5(22): 11669-11680.
TANG X., Huang J. and Guan X., ASCL1 is Essential in Maintaining CD133+ Cancer Stem Cells in HCC, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.
Tang Z., Li S., Guan X., Schmitt-Kopplin P., Lin S. and Cai Z., Rapid assessment of the coenzyme Q10 redox state using ultrahigh performance liquid chromatography tandem mass spectrometry, Analyst. 2014, 139: 5600-5604.
Tong M., Fung T.M., Luk T.C.S., Ng K.Y., Lee K.W., Lin C., Yam J.W.P., Chan K.W., Ng F., Zheng B., Yuan Y.F., Xie D., Lo C.M., Man K., Guan X. and Ma S.K.Y., ANXA3/JNK Signaling Promotes Self-Renewal and Tumor Growth, and Its Blockade Provides a Therapeutic Target for Hepatocellular Carcinoma, Stem Cell Reports. 2015.
WANG J., Liu M., Chen L., JIANG L., Yuan Y.F. and Guan X., Overexpression of N-terminal kinase like gene promotes tumorigenicity of hepatocellular carcinoma by regulating cell cycle progression and cell motility, Oncotarget. 2015, 6(3): 1618-1630.
WANG N., Wang Z., Shen J., Peng C., YOU J., PENG F., Guan X. and Chen J., Dietary compound Isoliquiritigenin prevents mammary carcinogenesis by inhibiting breast cancer stem cells through WIF1 demethylation, Oncotarget. 2015, 6(12): 9854-9876.
Wang F.W., Cai M.Y., Mai S.J., Chen J.W., Bai H.Y., Li Y., Liao Y.J., Li C.P., Tian X.P., Kung H.F., Guan X. and Xie D., Ablation of EIF5A2 induces tumor vasculature remodeling and improves tumor response to chemotherapy via regulation of matrix metalloproteinase 2 expression, Oncotarget. 2014, 5(16): 6716-6733.
Wang Y., Su P., Hu B., Zhu W., Li Q., Yuan P., Li J., Guan X., Li F., Jing X., Li R., Zhang Y., Férec C., Cooper D.N., Wang J., Huang D., Chen J.M. and Wang Y., Characterization of 26 deletion CNVs reveals the frequent occurrence of micro-mutations within the breakpoint-flanking regions and frequent repair of double-strand breaks by templated insertions derived from remote genomic regions, Human Genetics. 2015, 134(6): 589-603.
Yeung W.H., Lo C.M., Geng W., Li C., Ng K.T.P., Guan X., Poon R.T.P. and Man K., Alternative activated (M2) macrophages promoted tumor growth and invasiveness in Hepatocellular Carcinoma, 第九屆全國免疫學學 術大會, 2014.
Yeung W.H., Lo C.M., Ling C., Qi X., Geng W., Li C., Ng K.T.P., Forbes S.J., Guan X., Poon R.T.P., Fan S.T. and Man K., Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma, Journal of Hepatology. 2015, 62(3): 607-616.
Zheng F., Liao Y.J., Cai M.Y., Liu T.H., Chen S.P., Wu P.H., Wu L., Bian X.W., Guan X., Zeng Y.X., Yuan Y.F., Kung H.F. and Xie D., Systemic delivery of microRNA-101 potently inhibits hepatocellular carcinoma in vivo by repressing multiple targets, PLoS Genetics. 2015, 11(2): e1004873.


Researcher : Guan X.

Project Title:49th Annual Meeting of the American Society of Human Genetics The Association of Chromosome 8p Deletion and Tumor Metastasis in Human Hepatocellular Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/1999


Project Title:51st Annual Meeting of the American Society of Human Genetics Loss of Tyrosine Aminotransferase may Contribute to the Development of Hepatocellular Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2001


Project Title:Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2009


Project Title:Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2009


Project Title:The Liver Cancer Genome Project: translating genetic discoveries to clinical benefits
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Theme-based Research Scheme
Start Date:12/2011


Project Title:A novel strategy for prevention and treatment of HIV-1 infection
Investigator(s):Guan X, Zhang M
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:12/2012


Project Title:Analysis of the role of ATOH8 and HCC cancer stem cell and somatic cell reprogramming
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2013


Project Title:Outstanding Researcher Award 2011-12
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Outstanding Researcher Award
Start Date:01/2013


Project Title:Characterization of CHD1L in regulating hepatocellular carcinoma stemness and self-renewal
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2013


Project Title:Cancer
Investigator(s):Guan X, Chan CLW, Tsao GSW
Department:Clinical Oncology
Source(s) of Funding:Seed Funding for Strategic Research Theme
Start Date:11/2013


Project Title:Characterization of the effect of Epstein-Barr Virus encoded BART microRNAs on enhancing tumor-initiating properties and potentially serve as biomarkers in Nasopharyngeal Carcinoma
Investigator(s):Guan X, Kwong DLW
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2014


Project Title:Characterization of the regulatory roles of CHD1L in stemness and differentiation in hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2014


Project Title:Characterization of tumor suppressive function of HBP21 in hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:06/2014


Project Title:Exploring the Mechanism for Cancer Associated Fibroblasts Recruitment and the Potential Therapeutic Value in Esophageal Squamous Cell Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2015


Project Title:Investigation of the role of Maelstrom in cancer stem cell reprogramming
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2015


Project Title:Investigation of effects and molecular mechanisms of FGFR2-positive cancer-associate fibroblasts on tumor microenvironment in esophageal squamous cell carcinoma
Investigator(s):Guan X, Chen Z, Ma SKY
Department:Clinical Oncology
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:04/2015


Project Title:Establishing an intracellular targeting antibody platform for cancer treatment
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:05/2015


List of Research Outputs



Researcher : Guan XY

Project Title:49th Annual Meeting of the American Society of Human Genetics The Association of Chromosome 8p Deletion and Tumor Metastasis in Human Hepatocellular Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/1999


Project Title:51st Annual Meeting of the American Society of Human Genetics Loss of Tyrosine Aminotransferase may Contribute to the Development of Hepatocellular Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2001


Project Title:Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2009


Project Title:Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2009


Project Title:The Liver Cancer Genome Project: translating genetic discoveries to clinical benefits
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Theme-based Research Scheme
Start Date:12/2011


Project Title:A novel strategy for prevention and treatment of HIV-1 infection
Investigator(s):Guan X, Zhang M
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:12/2012


Project Title:Analysis of the role of ATOH8 and HCC cancer stem cell and somatic cell reprogramming
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2013


Project Title:Outstanding Researcher Award 2011-12
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Outstanding Researcher Award
Start Date:01/2013


Project Title:Characterization of CHD1L in regulating hepatocellular carcinoma stemness and self-renewal
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2013


Project Title:Cancer
Investigator(s):Guan X, Chan CLW, Tsao GSW
Department:Clinical Oncology
Source(s) of Funding:Seed Funding for Strategic Research Theme
Start Date:11/2013


Project Title:Characterization of the effect of Epstein-Barr Virus encoded BART microRNAs on enhancing tumor-initiating properties and potentially serve as biomarkers in Nasopharyngeal Carcinoma
Investigator(s):Guan X, Kwong DLW
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2014


Project Title:Characterization of the regulatory roles of CHD1L in stemness and differentiation in hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2014


Project Title:Characterization of tumor suppressive function of HBP21 in hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:06/2014


Project Title:Exploring the Mechanism for Cancer Associated Fibroblasts Recruitment and the Potential Therapeutic Value in Esophageal Squamous Cell Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2015


Project Title:Investigation of the role of Maelstrom in cancer stem cell reprogramming
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2015


Project Title:Investigation of effects and molecular mechanisms of FGFR2-positive cancer-associate fibroblasts on tumor microenvironment in esophageal squamous cell carcinoma
Investigator(s):Guan X, Chen Z, Ma SKY
Department:Clinical Oncology
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:04/2015


Project Title:Establishing an intracellular targeting antibody platform for cancer treatment
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:05/2015


List of Research Outputs



Researcher : Ho RLKY

List of Research Outputs

Cheng Y., Ho R.L.K.Y., Chan K.C., Kan R.J.A., Tung E., Lung H.L., Yau W.L., Cheung A.K.L., Ko J.M.Y., Zhang Z.F., Luo D.Z., Feng Z.B., Chen S., Guan X., Kwong D.L.W., Stanbridge E.J. and Lung M.L., Anti-angiogenic pathway associations of the 3p21.3 mapped BLU gene in nasopharyngeal carcinoma, Oncogene. 2014.


Researcher : Ip JCY

List of Research Outputs

Chan K.C., Chan L.S., Ip J.C.Y., Lo C., Yip T.T.C., Ngan R.K.C., Wong R.N.S., Lo K.W., Ng W.T., Lee A.W.M., Tsao G.S.W., Kahn M., Mak N.K. and Lung M.L., Therapeutic targeting of CBP/β-catenin signaling reduces cancer stem-like population and synergistically suppresses growth of EBV-positive nasopharyngeal carcinoma cells with cisplatin, Scientific Reports. 2015, 5: 9979.
Cheng Y., Phoon Y.P., Jin X., Chong S.Y.S., Ip J.C.Y., Wong W.Y. and Lung M.L., Wnt-C59 arrests stemness and suppresses growth of nasopharyngeal carcinoma in mice by inhibiting the Wnt pathway in the tumor microenvironment, Oncotarget. 2015, 6: 14428-39.
Cheung A.K.L., Ip J.C.Y., Chu C.H.A., Cheng Y., Leong M.L., Ko J.M.Y., Shuen W.H., Lung H.L. and Lung M.L., PTPRG suppresses tumor growth and invasion via inhibition of Akt signaling in nasopharyngeal carcinoma, Oncotarget. 2015, 6: 13434-47.
Ip J.C.Y., Ko J.M.Y., Yu Z., Chan K.W., Lam A.K., Law S.Y.K., Tong D.K.H. and Lung M.L., A Versatile Orthotopic Nude Mouse Model for Study of Esophageal Squamous Cell Carcinoma, In: Dominic Fan, BioMed Research International. New York, USA, Hindawi Publishing Corporation, 2015, 2015.
Ip J.C.Y., Ko J.M.Y., Yu Z., Chan K.W., Lam A.K.Y., Law S.Y.K., Tong D.K.H. and Lung M.L., Establishment of an orthotopic oesophageal squamous cell carcinoma animal model visualised by bioluminescence imaging and recapitulating the tumour-stromal microenvironment, 19th Research Postgraduate Symposium HKU, Hong Kong. 2014.


Researcher : JIANG L

List of Research Outputs

Liu M., JIANG L. and Guan X., The genetic and epigenetic alterations in human hepatocellular carcinoma: a recent update, Protein & Cell. 2014, 5: 673-691.
WANG J., Liu M., Chen L., JIANG L., Yuan Y.F. and Guan X., Overexpression of N-terminal kinase like gene promotes tumorigenicity of hepatocellular carcinoma by regulating cell cycle progression and cell motility, Oncotarget. 2015, 6(3): 1618-1630.


Researcher : Jin X

List of Research Outputs

Cheng Y., Phoon Y.P., Jin X., Chong S.Y.S., Ip J.C.Y., Wong W.Y. and Lung M.L., Wnt-C59 arrests stemness and suppresses growth of nasopharyngeal carcinoma in mice by inhibiting the Wnt pathway in the tumor microenvironment, Oncotarget. 2015, 6: 14428-39.


Researcher : KAN PQR

List of Research Outputs

KAN P.Q.R., Shuen W.H. and Lung M.L., Extracellular matrix protein, LTBP2, regulates the nuclear trafficking of canonical NF-kB p65 to mediate tumor suppressive effect in NPC, 21st Hong Kong International Cancer Congress. Hong Kong, China. 2014.
KAN P.Q.R., Shuen W.H., Lung H.L., Cheung A.K.L., Dai W., Kwong D.L.W., Ng W.T., Lee A.W.M., Yau C.C., Ngan R.K., Tung S. and Lung M.L., NF-κB p65 Subunit Is Modulated by Latent Transforming Growth Factor-β Binding Protein 2 (LTBP2) in Nasopharyngeal Carcinoma HONE1 and HK1 Cells, PLOS ONE. 2015, 10: e0127239.
SHUEN W.H., KAN P.Q.R., Yu Z., Lung H.L. and Lung M.L., Novel lentiviral-inducible transgene expression systems and versatile single-plasmid reporters for in vitro and in vivo cancer biology studies, Cancer Gene Therapy. 2015, 22: 207-214.


Researcher : Ko JMY

Project Title:Study of alternative splicing of esophageal squamous cell carcinoma through transcriptome analysis in Hong Kong
Investigator(s):Ko JMY, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:06/2014


Project Title:The clinical relevance of telomere attrition and NPC genetic susceptibility
Investigator(s):Ko JMY, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:02/2015


Project Title:7th BIANNUAL INTERNATIONAL SYMPOSIUM ON NASOPHARYNGEAL CARCINOMA 2015; THE GENETIC SUSCEPTIBILITY AND PROGNOSTIC ROLE OF TERT-CLPTM1L AND GENES IN DNA DAMAGE PATHWAYS IN NPC
Investigator(s):Ko JMY
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2015


List of Research Outputs

Cheng Y., Ho R.L.K.Y., Chan K.C., Kan R.J.A., Tung E., Lung H.L., Yau W.L., Cheung A.K.L., Ko J.M.Y., Zhang Z.F., Luo D.Z., Feng Z.B., Chen S., Guan X., Kwong D.L.W., Stanbridge E.J. and Lung M.L., Anti-angiogenic pathway associations of the 3p21.3 mapped BLU gene in nasopharyngeal carcinoma, Oncogene. 2014.
Cheung A.K.L., Ip J.C.Y., Chu C.H.A., Cheng Y., Leong M.L., Ko J.M.Y., Shuen W.H., Lung H.L. and Lung M.L., PTPRG suppresses tumor growth and invasion via inhibition of Akt signaling in nasopharyngeal carcinoma, Oncotarget. 2015, 6: 13434-47.
Dai W., Cheung A.K.L., Ko J.M.Y., Cheng Y., ZHENG H., Kwong D.L.W., Ngan R., Ng W.T., Lee A.W.M., Yau C.C. and Lung M.L., Aberrant methylation at chromosome 6p as novel biomarkers for diagnosis and prognosis of nasopharyngeal carcinoma, 106th American Association of Cancer Research. Philadelphia, Pennsylvania, USA. 2015.
Dai W., Cheung A.K.L., Ko J.M.Y., Cheng Y., Zheng H., Ngan R., Ngan W.T., Lee A.W.M., Yau C.C., Lee V.H.F. and Lung M.L., Comparative methylome analysis in solid tumors reveals aberrant methylation at chromosome 6p in nasopharyngeal carcinoma, Cancer Medicine. 2015, n/a-n/a.
Dai W., ZHENG H., Tang S.M., Sham P.C., Ko J.M.Y., Cheung A.K.L. and Lung M.L., Using Next-generation Whole-Exome Sequencing Approaches to Elucidate the Genetic Basis for Nasopharyngeal Carcinoma , Gorden Research Conference Genomic Instability. 2014.
Ip J.C.Y., Ko J.M.Y., Yu Z., Chan K.W., Lam A.K., Law S.Y.K., Tong D.K.H. and Lung M.L., A Versatile Orthotopic Nude Mouse Model for Study of Esophageal Squamous Cell Carcinoma, In: Dominic Fan, BioMed Research International. New York, USA, Hindawi Publishing Corporation, 2015, 2015.
Ip J.C.Y., Ko J.M.Y., Yu Z., Chan K.W., Lam A.K.Y., Law S.Y.K., Tong D.K.H. and Lung M.L., Establishment of an orthotopic oesophageal squamous cell carcinoma animal model visualised by bioluminescence imaging and recapitulating the tumour-stromal microenvironment, 19th Research Postgraduate Symposium HKU, Hong Kong. 2014.
Ko J.M.Y., Dai W., Wong E.H.W., Kwong D.L.W., Ng W.T., Lee A., Ngan R.K.C., Yau C.C., Tung S. and Lung M.L., Case-control association studies of DNA damage repair genes associated with genetic susceptibility of nasopharyngeal carcinoma , Gordon Research Conference Genomic Instability. 2014.
Ko J.M.Y., Dai W., Wong H.W.E., Kwong D.L.W., Ng W.T., Lee A.W.M., Ngan R.K., Yau C.C., Tung S. and Lung M.L., Cumulative effects of TERT-CLPTM1L and double-strand breaks repair contribute to higher risk for nasopharyngeal carcinoma, Gordon Research Conferences Genomic Instability Hong Kong. 2014.
Ko J.M.Y., Zhang P., Law S.Y.K., Fan Y., Song Y., Zhao X.K., Wong H.W.E., Tang S., Song X., Lung M.L. and Wang L.D., Identity-by-descent approaches identify regions of importance for genetic susceptibility to hereditary esophageal squamous cell carcinoma, Oncology Reports. 2014, 32(2): 860-870.
Ko J.M.Y., Dai W., Kwong D.L.W., Ng W.T., Lee A.W.M., Ngan R.C., Yau C.C., Tung S. and Lung M.L., The genetic susceptibility and prognostic role of TERT-CLPTM1L and dnes in DNA damage pathways in NPC, 7th International NPC Biannual Meeting. Yogyakarta, Indonesia. 2015.
Lung M.L., Cheung A.K.L., Ko J.M.Y., Lung H.L., Cheng Y. and Dai W., The interplay of host genetic factors and Epstein-Barr virus in the development of nasopharyngeal carcinoma, Chinese Journal of Cancer. 2014, 33: 556-568.
ZHENG H., Dai W., Tang S.M., Cheung A.K.L., Ko J.M.Y., Sham P.C. and Lung M.L., Unraveling the genetic basis of nasopharyngeal carcinoma using next-generation sequencing approaches, 106th American Association of Cancer Research. Philadelphia, Pennsylvania, USA. 2015.


Researcher : Kwong DLW

Project Title:PET/CT scan for early response monitoring and radiation dose escalation in locally advanced nasopharyngeal carcinoma
Investigator(s):Kwong DLW, Khong PL, Lee VHF
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2012


Project Title:5th World Congress-IFHNOS & Annual Meeting - AHNS; Radiotherapy for nasopharyngeal carcinoma: Radiotherapy for Recurrent Tumors
Investigator(s):Kwong DLW
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:07/2014
Completion Date:07/2014


List of Research Outputs

Blanchard P., Lee W.M.A., Marguet S., Leclercq J., Ng W.T., Ma J., Chan A.T.C., Huang P.Y., Benhamou E., Zhu G., Chua D.T., Chen Y., Mai H.Q., Kwong D.L.W., Cheah S.L., Moon J., Tung Y., Chi K.H., Fountzils G., Zhang L., Hui E.P., Lu T.X., Bourhis J. and Pignon J.P., Chemotherapy and radiotherapy in nasopharyngeal carcinoma: an update of the MAC-NPC meta-analysis, The Lancet Oncology. 2015, 16: 645-655.
Chan M.K.H., Kwong D.L.W., Lee V.W.Y., Leung R.W.K., Wong M.Y.P. and Blanck O., Feasibility study of robotic hypofractionated lung radiotherapy by individualized internal target volume and XSight Spine Tracking: A preliminary dosimetric evaluation, Journal of Cancer Research and Therapeutics. 2015, 11: 150.
Cheng S.C., Wu V.W.C., Kwong D.L.W., Lui C.Y., Cheng C.K., Kot B.C. and Ying M.T., Sonographic appearance of thyroid glands in patients treated with intensity-modulated radiotherapy or conventional radiotherapy for nasopharyngeal carcinoma , Journal of Clinical Ultrasound . 2014 Wiley Periodicals, Inc., 2014.
Cheng Y., Ho R.L.K.Y., Chan K.C., Kan R.J.A., Tung E., Lung H.L., Yau W.L., Cheung A.K.L., Ko J.M.Y., Zhang Z.F., Luo D.Z., Feng Z.B., Chen S., Guan X., Kwong D.L.W., Stanbridge E.J. and Lung M.L., Anti-angiogenic pathway associations of the 3p21.3 mapped BLU gene in nasopharyngeal carcinoma, Oncogene. 2014.
Cheuk I.W., Yip S.P., Kwong D.L.W. and Wu V.W.C., Association of XRCC1 and XRCC3 gene haplotypes with the development of radiation-induced fibrosis in patients with nasopharyngeal carcinoma., Molecular and Clinical Oncology. 2014.
Chiang A.K.S., Kwok H., Palser A.L. and Kwong D.L.W., Genomic diversity of Epstein-Barr virus genomes isolated from primary nasopharyngeal carcinoma biopsies, 16th International Symposium on EBV and Associated Diseases. 2014.
Dai W., Cheung A.K.L., Ko J.M.Y., Cheng Y., ZHENG H., Kwong D.L.W., Ngan R., Ng W.T., Lee A.W.M., Yau C.C. and Lung M.L., Aberrant methylation at chromosome 6p as novel biomarkers for diagnosis and prognosis of nasopharyngeal carcinoma, 106th American Association of Cancer Research. Philadelphia, Pennsylvania, USA. 2015.
Huang B., Wong C.Y., Lai V., Kwong D.L.W. and Khong P.L., Prognostic Value of 18 F-FDG PET-CT in Nasopharyngeal Carcinoma: Is Dynamic Scanning Helpful? , BioMed Research International. 2015, 2015: 1-7.
KAN P.Q.R., Shuen W.H., Lung H.L., Cheung A.K.L., Dai W., Kwong D.L.W., Ng W.T., Lee A.W.M., Yau C.C., Ngan R.K., Tung S. and Lung M.L., NF-κB p65 Subunit Is Modulated by Latent Transforming Growth Factor-β Binding Protein 2 (LTBP2) in Nasopharyngeal Carcinoma HONE1 and HK1 Cells, PLOS ONE. 2015, 10: e0127239.
Ko J.M.Y., Dai W., Wong E.H.W., Kwong D.L.W., Ng W.T., Lee A., Ngan R.K.C., Yau C.C., Tung S. and Lung M.L., Case-control association studies of DNA damage repair genes associated with genetic susceptibility of nasopharyngeal carcinoma , Gordon Research Conference Genomic Instability. 2014.
Ko J.M.Y., Dai W., Wong H.W.E., Kwong D.L.W., Ng W.T., Lee A.W.M., Ngan R.K., Yau C.C., Tung S. and Lung M.L., Cumulative effects of TERT-CLPTM1L and double-strand breaks repair contribute to higher risk for nasopharyngeal carcinoma, Gordon Research Conferences Genomic Instability Hong Kong. 2014.
Ko J.M.Y., Dai W., Kwong D.L.W., Ng W.T., Lee A.W.M., Ngan R.C., Yau C.C., Tung S. and Lung M.L., The genetic susceptibility and prognostic role of TERT-CLPTM1L and dnes in DNA damage pathways in NPC, 7th International NPC Biannual Meeting. Yogyakarta, Indonesia. 2015.
Kwok H., Wu C.W., Palser A.L., Kellam P., Sham P.C., Kwong D.L.W. and Chiang A.K.S., Genomic diversity of Epstein-Barr virus genomes isolated from primary nasopharyngeal carcinoma biopsy samples, In: Kwok H, Wu CW, Palser AL, Kellam P, Sham PC, Kwong DL, Chiang AKS, Journal of Virology. 2014, 88(18):10662: DOI:10.1128/JVI.01665-14.
Kwong D.L.W., 1. Chemotherapy for nasopharyngeal carcinoma: does sequence matter? 2. Conformal radiotherapy for nasopharyngeal carcinoma: potentials and caveats. 3. Panelist in Panel Session: Nasopharyngeal carcinoma clinical cases and discussion, Tri-society Head & Neck Oncology Meeting 2014, 14-16 Aug., 2014, Darwin, Australia. 2014.
Kwong D.L.W., 1. Dose escalation in IMRT for locally advanced NPC. 2. Intracranial complications after radiotherapy for NPC. 3. Moderator in Round Table Discussion., Hong Kong Nasopharyngeal Cancer Symposium 2014, 23-24 Aug., 2014. 2014.
Kwong D.L.W., Lee V.H.F., Lam K.O., Wong G.K.W. and Khong P.L., Biological tumor volume (BTV) as a predictor for local control in nasopharyngeal carcinoma (NPC), 2015 American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago, USA, 29 May - 2 June 2015, 2015.
Kwong D.L.W., Lee V.H.F. and Khong P.L., Early response assessment by PET scan in chemoradiotherapy for nasopharyngeal carcinoma, European Society for Medical Oncology. Madrid, Spain, 2014.
Kwong D.L.W., Nasopharyngeal carcinoma and Epstein Barr Virus (EBV) , At Gold Coast University Hospital, Australia. 2014.
Kwong D.L.W., Lee V.H.F. and Khong P.L., Poster presentation: Early response assessment by PET scan in chemoradiotherapy for nasopharyngeal carcinoma, European Society for Medical Oncology, ESMO 2014, Madrid, Spain, 26-30 Sept., 2014.
Kwong D.L.W., Radiotherapy and Chemotherapy for Head and Neck Cancers, 21st Certificate Course in ENT for Nurses, Tung Wah Hospital, Hong Kong., 2015.
Kwong D.L.W., Radiotherapy for recurrent tumors, 5th World Congress of International Federation of Head and Neck Oncologic Societies & Annual Meeting of the American Head and Neck Society, 26-30 July, 2014, New York. Panelist in Panel 9: Nasopharyngeal Carcinoma. 2014.
Kwong D.L.W. and Chan Y.W., Salvage treatment for local recurrence , In: Sue Yom, Joseph Wee, Nasopharyngeal Carcinoma: Management Strategies . Future Medicine Ltd., 2014, 137-149.
Lam K.O., Cheung G., Sze C.K.H., Lee V.H.F., Tsang J.W.H., Choy T.S., Leung T.W. and Kwong D.L.W., The impact of complete metabolic response in the treatment of metastatic colorectal cancer, In: Annals of Oncology, 39th European Society for Medical Oncologist Congress. 2014.
Lee V.H.F., Kwong D.L.W., Lam K.O., Sze C.K.H., Ho P.P.Y., Chan W.L., Leung D.K.C., Wong L.S. and Leung T.W., Comparison of post-treatment plasma EBV DNA with nasopharyngeal biopsy in patients after radical (chemo)radiotherapy for non-metatatic nasopharyngeal cancer., American Society for Radiation Oncology 56th Annual Meeting. San Francisco, USA, American Society for Radiation Oncology, 2014.
Lee W.M.A., Ngan K.C., Tung S.Y., Cheng A., Kwong D.L.W., Lu T.X., Chan A.T.C., Chan L.L.K., Yiu H., Ng W.T., Wong F., Yuen K.T., Yau S., Cheung F.Y., Chan O.S.H., Choi H. and Chappell R., Preliminary results of trial NPC-0501 evaluating the therapeutic gain by changing from concurrent-adjuvant to induction-concurrent chemoradiotherapy, changing from fluorouracil to capecitabine, and changing from conventional to accelerated radiotherapy fr, Cancer. 2015, 121: 1328-1338.
Li J.Y., Pow E.H.N., Zheng L., Ma L., Kwong D.L.W. and Cheung L.K., Effects of calcium phosphate nanocrystals on osseointegration of titainium implant in irradiated bone, BioMed Research International. 2015, 2015: 1-6.
WONG K.W., Kwong D.L.W., Khong P.L., Lee V.H.F., Ng C.Y. and Law W.M., Delineation of Biological Tumor Volume from Positron Emission Tomography Images in Nasopharyngeal Carcinoma, Biomedical Science and Engineering. authors and Scientific Research Publishing Inc., 2014, 7(11): 857-865.
Wong K.W., Kwong D.L.W., Khong P.L., Lee V.H.F., Ng C.Y. and Law M.W.M., Delineation of Biological Tumor Volume from Positron Emission Tomography Images in Nasopharyngeal Carcinoma., Journal of Biomedical Science and Engineering. 2014.
YANG X., Dai W., Kwong D.L.W., Szeto C.Y.Y., Wong H.W.E., Ng W.T., Lee A.W.M., Ngan K.C., Yau C.C., Tung S.Y. and Lung M.L., Epigenetic markers for non-invasive early detection of nasopharyngeal carcinoma by methylation-sensitive high resolution melting, International Journal of Cancer. 2014.
Yuan C., Wu V.W.C., Yip S.P., Kwong D.L.W., Ying M. and Feng Y., Predictors of the Extent of Carotid Atherosclerosis in Patients Treated with Radiotherapy for Nasopharyngeal Carcinoma, PLoS ONE. 2014, 9: e116284.
Yuan C., Wu V.W.C., Yip S.P., Kwong D.L.W. and Ying M., Ultrasound Evaluation of Carotid Atherosclerosis in Post-Radiotherapy Nasopharyngeal Carcinoma Patients, Type 2 Diabetics, and Healthy Controls., Ultraschall Med. 2015.


Researcher : Kwong WKP

List of Research Outputs

Lee E.Y.P., Hui S.K., Chan K.K.L., Tse K.Y., Kwong W.K.P., Chang T.Y., Chan Q. and Khong P.L., Relationship between intravoxel incoherent motion diffusion-weighted MRI and dynamic contrast-enhanced MRI in tissue perfusion of cervical cancers, Journal of Magnetic Resonance Imaging. 2014, n/a-n/a.


Researcher : LI J

List of Research Outputs

Song Y., LI J., Zhu Y., Dai Y., Zeng T., Liu L., Li J., Wang H., Qin Y., Zeng M., Guan X. and Li Y., MicroRNA-9 promotes tumor metastasis via repressing E-cadherin in esophageal squamous cell carcinoma, Oncotarget. 2014, 5(22): 11669-11680.


Researcher : LI Y

List of Research Outputs

Guan X., Chen L., Ma S.K.Y., Li Y. and Liu M., Molecular mechanisms of development and progression of hepatocellular carcinoma, Science and Technology Prize of Higher Education of China (Natural Science, Second-class). 2014.
Li Y., Chan H.M., Chen L., Chow K.K., Guan X., Liu M. and Lin C., Faculty Outstanding Research Output, Faculty of Medicine, The University of Hong Kong. 2014.
SONG Y., Pan G., Chen L., Ma S.K.Y., Zeng T., Chan T.H., Li L., Lian Q., CHOW K.K., Cai X., Li Y., Li Y., Liu M., LI Y., Zhu Y., Wong N., Yuan Y.F., Pei D. and Guan X., Loss of ATOH8 increases stem cell features of hepatocellular carcinoma cells, Gastroenterology. 2015.


Researcher : Lam KO

Project Title:A prospective study on the predictive and prognostic value of baseline biomarker expressions in locally advanced rectal cancer treated with neoadjuvant chemoradiation using capecitabine
Investigator(s):Lam KO, Kwong DLW, Lee VHF
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2012
Completion Date:07/2014


Project Title:HKU Overseas Fellowship Awards 2013-14
Investigator(s):Lam KO
Department:Clinical Oncology
Source(s) of Funding:HKU Overseas Fellowship Awards
Start Date:08/2013
Completion Date:08/2014


Project Title:PD-L1 immunohistochemical expression in esophageal cancers
Investigator(s):Lam KO, Kwong DLW, Lee VHF, Law SYK
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:04/2015


List of Research Outputs

Kwong D.L.W., Lee V.H.F., Lam K.O., Wong G.K.W. and Khong P.L., Biological tumor volume (BTV) as a predictor for local control in nasopharyngeal carcinoma (NPC), 2015 American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago, USA, 29 May - 2 June 2015, 2015.
Lai V., Lee V.H.F., Lam K.O., Sze C.K.H., Chan Q.U.E.E.N.I.E. and Khong P.L., Intravoxel water diffusion heterogeneity MR imaging of nasopharyngeal carcinoma using stretched exponential diffusion model, European Radiology. 2014.
Lam K.O., Anti-EGFR Treatment in mCRC: Which Patient and How in 2016, In: Lancet Oncology, Asian Oncology Summit 2015. 2015.
Lam K.O., Asian Study and Local Experience of Regorafenib in Treating mCRC patients, Hong Kong Society of Clinical Oncology Scientific Symposium . 2015.
Lam K.O., Associate Editor, In: Dr. Chan, Lam, Modern Chemotherapy. 2014.
Lam K.O., Case Discussion in Colon Cancer, Qilu MDT Symposium for Colorectal Cancer. 2014.
Lam K.O., Case Discussion in Rectal Cancer, Qilu MDT Symposium for Colorectal Cancer. 2014.
Lam K.O., Cetuximab with Oxaliplatin-Based Chemotherapy for mCRC: Infusional and Oral Fluoropyrimidine in Clinical Practice, The 3rd Oncology Summit. 2014.
Lam K.O., Challenging Case Workshop in Gastrointestinal Cancers: Metastatic CRC 2nd Line (Kras WT), Asia-Pacific Oncology Conference. 2014.
Lam K.O., Incorporating Multikinase Inhibition Into the Treatment of mCRC. 2014.
Lam K.O., Incorporating Multikinase Inhibitor into the Treatment of mCRC: Focus on Regorafenib: Local Experience and Case Sharing, Macao Oncology Association Scientific Symposium. 2015.
Lam K.O., Management of Colorectal Cancer: Revisiting the Role of Anti-Angiogenesis, The 28th AGM of Society of Hospital Pharmacists of Hong Kong. 2015.
Lam K.O., Medical Treatment for Spinal Metastasis, Hong Kong 2015-The Combined Congress of HKIOF, APSS and APPOS. 2015.
Lam K.O., Neoadjuvant Therapy for Rectal Cancer: Lessons From the Past, Qilu MDT Symposium for Colorectal Cancer. 2014.
Lam K.O., Personalised Medicine in Metastatic Colorectal Cancer – Lessons Learnt and The Road Ahead, The 22nd Annual Scientific Meeting of Hong Kong College of Radiologists. 2014.
Lam K.O., Personalised Medicine in Metastatic Colorectal Cancer, GSK Macau Round Table Discussion. 2014.
Lam K.O., State-of-the-Art Management of Metastatic Colorectal Cancer, The University of Hong Kong and Zhejiang University Co-Joint Cancer Symposium on Gastrointestinal Malignancies. 2015.
Lam K.O., Strategies to Optimize the Continuum of Care in mCRC patients, Annual Scientific Meeting of Hong Kong Association of Community Oncologists. 2014.
Lam K.O., Cheung G., Sze C.K.H., Lee V.H.F., Tsang J.W.H., Choy T.S., Leung T.W. and Kwong D.L.W., The impact of complete metabolic response in the treatment of metastatic colorectal cancer, In: Annals of Oncology, 39th European Society for Medical Oncologist Congress. 2014.
Lam K.O., Treatment Paradigm in Metastatic Colorectal Cancer, Qilu MDT Symposium for Colorectal Cancer. 2014.
Lee A.W.M., Sze C.K.H., Lam K.O. and Chen X., A tale of two cities in China: Hong Kong and Shenzhen, In: Anthony L Zietman, International Journal of Radiation Oncology, Biology and Physics. Elsevier Inc, 2014, 89: 704-708.
Lee V.H.F., Kwong D.L.W., Lam K.O., Sze C.K.H., Ho P.P.Y., Chan W.L., Leung D.K.C., Wong L.S. and Leung T.W., Comparison of post-treatment plasma EBV DNA with nasopharyngeal biopsy in patients after radical (chemo)radiotherapy for non-metatatic nasopharyngeal cancer., American Society for Radiation Oncology 56th Annual Meeting. San Francisco, USA, American Society for Radiation Oncology, 2014.
Sze C.K.H., Lam K.O. and Lee A.W.M., Early Stage Nasopharyngeal Carcinoma, In: Lauren Constable, Nasopharyngeal Carcinoma: management strategies. Future Medince, 2014.


Researcher : Lee AWM

List of Research Outputs

Chan K.C., Ting C.M., Chan P.S., Lo M.C., Lo K.W., Smyth T., Lee A.W.M., Ng W.T., Tsao G.S.W., Wong R.N., Lung M.L. and Mak N.K., Study of a novel Hsp90 inhibitor AT13387 as potential therapeutic agent in EBV-associated nasopharyngeal carcinoma, 16th International Symposium on EBV and Associated Diseases. Brisbane, Australia. 2014.
Chan K.C., Chan L.S., Ip J.C.Y., Lo C., Yip T.T.C., Ngan R.K.C., Wong R.N.S., Lo K.W., Ng W.T., Lee A.W.M., Tsao G.S.W., Kahn M., Mak N.K. and Lung M.L., Therapeutic targeting of CBP/β-catenin signaling reduces cancer stem-like population and synergistically suppresses growth of EBV-positive nasopharyngeal carcinoma cells with cisplatin, Scientific Reports. 2015, 5: 9979.
Dai W., Cheung A.K.L., Ko J.M.Y., Cheng Y., ZHENG H., Kwong D.L.W., Ngan R., Ng W.T., Lee A.W.M., Yau C.C. and Lung M.L., Aberrant methylation at chromosome 6p as novel biomarkers for diagnosis and prognosis of nasopharyngeal carcinoma, 106th American Association of Cancer Research. Philadelphia, Pennsylvania, USA. 2015.
KAN P.Q.R., Shuen W.H., Lung H.L., Cheung A.K.L., Dai W., Kwong D.L.W., Ng W.T., Lee A.W.M., Yau C.C., Ngan R.K., Tung S. and Lung M.L., NF-κB p65 Subunit Is Modulated by Latent Transforming Growth Factor-β Binding Protein 2 (LTBP2) in Nasopharyngeal Carcinoma HONE1 and HK1 Cells, PLOS ONE. 2015, 10: e0127239.
Ko J.M.Y., Dai W., Wong H.W.E., Kwong D.L.W., Ng W.T., Lee A.W.M., Ngan R.K., Yau C.C., Tung S. and Lung M.L., Cumulative effects of TERT-CLPTM1L and double-strand breaks repair contribute to higher risk for nasopharyngeal carcinoma, Gordon Research Conferences Genomic Instability Hong Kong. 2014.
Ko J.M.Y., Dai W., Kwong D.L.W., Ng W.T., Lee A.W.M., Ngan R.C., Yau C.C., Tung S. and Lung M.L., The genetic susceptibility and prognostic role of TERT-CLPTM1L and dnes in DNA damage pathways in NPC, 7th International NPC Biannual Meeting. Yogyakarta, Indonesia. 2015.
Lee A.W.M., Sze C.K.H., Lam K.O. and Chen X., A tale of two cities in China: Hong Kong and Shenzhen, In: Anthony L Zietman, International Journal of Radiation Oncology, Biology and Physics. Elsevier Inc, 2014, 89: 704-708.
Sze C.K.H., Lam K.O. and Lee A.W.M., Early Stage Nasopharyngeal Carcinoma, In: Lauren Constable, Nasopharyngeal Carcinoma: management strategies. Future Medince, 2014.
YANG X., Dai W., Kwong D.L.W., Szeto C.Y.Y., Wong H.W.E., Ng W.T., Lee A.W.M., Ngan K.C., Yau C.C., Tung S.Y. and Lung M.L., Epigenetic markers for non-invasive early detection of nasopharyngeal carcinoma by methylation-sensitive high resolution melting, International Journal of Cancer. 2014.


Researcher : Lee VHF

Project Title:Complementary EBV DNA testing for the poor and sick patents diagnosed to have nasopharyngeal carcinoma
Investigator(s):Lee VHF, Kwong DLW
Department:Clinical Oncology
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:09/2010


Project Title:Complimentary EBV DNA testing for the poor and sick patients diagnosed to have nasopharyngeal carcinoma
Investigator(s):Lee VHF, Kwong DLW
Department:Clinical Oncology
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:02/2012


Project Title:Identification of epithelial stem cells and factors predicting recovery of mucositis after intensity modulated radiation therapy (IMRT) for patients with nasopharyngeal carcinoma (NPC)
Investigator(s):Lee VHF, Guan X, Kwong DLW, Lam KO
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:06/2013


Project Title:Complimentary EBV DNA testing for the poor and sick patients diagnosed to have nasopharyngeal carcinoma
Investigator(s):Lee VHF, Kwong DLW, Lam KO
Department:Clinical Oncology
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2014


Project Title:Granulocyte-colony stimulating factor (G-CSF) support to prevent neutropenia and its complications for patients receiving palliative chemotherapy for their stage IV metastatic cancer
Investigator(s):Lee VHF, Kwong DLW, Lam KO
Department:Clinical Oncology
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2014


Project Title:Development of Cancer Registry of Human Papilloma Virus (HPV)-associated Oral and Oropharyngeal Cancers in Hong Kong and its Correlation with Survival Outcomes
Investigator(s):Lee VHF, Kwong DLW, Lam KO, Sze CKH
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:06/2014


Project Title:ASTRO 56th Annual Meeting; Comparison of Post-treatment Plasma EBV DNA with Nasopharyngeal Biopsy in Patients After Radical (Chemo)Radiotherapy for Non-metastatic Nasopharyngeal Cancer
Investigator(s):Lee VHF
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:09/2014


Project Title:Magnetic resonance imaging (MRI) for monitoring treatment response in patients with inoperable hepatocellular carcinoma treated with transarterial chemoembolization (TACE) and/or radiotherapy
Investigator(s):Lee VHF, Kwong DLW, Wong CS
Department:Clinical Oncology
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2015


List of Research Outputs

Dai W., Cheung A.K.L., Ko J.M.Y., Cheng Y., Zheng H., Ngan R., Ngan W.T., Lee A.W.M., Yau C.C., Lee V.H.F. and Lung M.L., Comparative methylome analysis in solid tumors reveals aberrant methylation at chromosome 6p in nasopharyngeal carcinoma, Cancer Medicine. 2015, n/a-n/a.
GAO X., Lin C., Kwan T.K., Lee V.H.F., Chan S.H., Sihoe D.L.A., Au S.K., Tin P.C., XIAO Z., Yam J.W.P., Wang J.J., Sham P.C. and Wong M.P., Application of whole exome sequencing in metachronous lung cancers evaluation, European Association for Cancer Research, Cambridge. 2015.
Kwong D.L.W., Lee V.H.F., Lam K.O., Wong G.K.W. and Khong P.L., Biological tumor volume (BTV) as a predictor for local control in nasopharyngeal carcinoma (NPC), 2015 American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago, USA, 29 May - 2 June 2015, 2015.
Kwong D.L.W., Lee V.H.F. and Khong P.L., Early response assessment by PET scan in chemoradiotherapy for nasopharyngeal carcinoma, European Society for Medical Oncology. Madrid, Spain, 2014.
Kwong D.L.W., Lee V.H.F. and Khong P.L., Poster presentation: Early response assessment by PET scan in chemoradiotherapy for nasopharyngeal carcinoma, European Society for Medical Oncology, ESMO 2014, Madrid, Spain, 26-30 Sept., 2014.
Lai V., Lee V.H.F., Lam K.O., Sze C.K.H., Chan Q.U.E.E.N.I.E. and Khong P.L., Intravoxel water diffusion heterogeneity MR imaging of nasopharyngeal carcinoma using stretched exponential diffusion model, European Radiology. 2014.
Lam K.O., Cheung G., Sze C.K.H., Lee V.H.F., Tsang J.W.H., Choy T.S., Leung T.W. and Kwong D.L.W., The impact of complete metabolic response in the treatment of metastatic colorectal cancer, In: Annals of Oncology, 39th European Society for Medical Oncologist Congress. 2014.
Lau S.S.N., Taw B.T.B., Lee V.H.F., Hung K.N. and Lui W.M., X-knife stereotactic radiosurgery for cerebral AVM: Queen Mary Hospital experience, The 21st Annual Scientific Meeting of the Hong Kong Neurosurgical Society, Hong Kong, 5-6 December 2014.
Lee E.Y.P., Khong P.L., Lee V.H.F. and Wong M.P., Baseline FDG-PET/CT parameters may assist in predicting overall survival in TKI-treated stage IV lung adenocarcinoma., IASLC Asia Pacific Lung Cancer Conference, Kuala Lumpur, Malaysia. 2014.
Lee E.Y.P., Khong P.L., Lee V.H.F., Qian W., Yu X. and Wong M.P., Metabolic Phenotype of Stage IV Lung Adenocarcinoma: relationship with epidermal growth factor receptor mutation, Clinical Nuclear Medicine. 2015, 40: e190-e195.
Lee E.Y.P., Khong P.L., Lee V.H.F., Qian W., Yu X. and Wong M.P., Metabolic phenotype of metastasis in stage IV lung adenocarcinoma assists in predicting EGFR mutations., 15th AOCR. 2014.
Lee V.H.F., Kwong D.L.W., Lam K.O., Sze C.K.H., Ho P.P.Y., Chan W.L., Leung D.K.C., Wong L.S. and Leung T.W., Comparison of post-treatment plasma EBV DNA with nasopharyngeal biopsy in patients after radical (chemo)radiotherapy for non-metatatic nasopharyngeal cancer., American Society for Radiation Oncology 56th Annual Meeting. San Francisco, USA, American Society for Radiation Oncology, 2014.
Lee V.H.F., Does Head and Neck Mucosal Melanoma Resemble the Cutaneous Type?, Tri-Sociey Head and Neck Oncology Meeting 2014. Darwin, Australia, 2014.
Lee V.H.F., Palliative Chemotherapy and Targeted Therapy for Recurrent/Metastatic NPC - Any Role when used Beyond Progression?, Tri-Society Head and Neck Oncology Meeting 2014. 2014.
Lee V.H.F., Palliative Chemotherapy and Targeted Therapy for Recurrent/Metastatic Nasopharyngeal Cancer, 5th World Congress of IFHNOS and the Annual Meeting of the AHNS. New York, USA, IFHNOS and AHNS, 2014.
Lee V.H.F., Predictors of Relapse in Nasopharyngeal Cancer, In: Jimmy Yu-Wai CHAN, Victor Ho-Fun LEE, Hong Kong Nasopharyngeal Cancer Symposium 2014. Hong Kong, 2014.
Lee V.H.F., Treatment of Unresectable Recurrent Nasopharyngeal Cancer, In: Jimmy Yu-Wai CHAN, Victor Ho-Fun LEE, Hong Kong Nasopharyngeal Cancer Symposium 2014. Hong Kong, 2014.
Mok T.S., Geater S.L., Iannotti N., Thongprasert S., Spira A., Smith D., Lee V.H.F., Lim W.T., Reyderman L. and Wang B., Randomized phase II study of two intercalated combinations of eribulin mesylate and erlotinib in patients with previously treated advanced non-small-cell lung cancer, Annals of Oncology. 2014, 25: 1578-1584.
Seneviratne C.J., Fong H.L., Wong S.S.W. and Lee V.H.F., Antifungal susceptibility and phenotypic characterization of oral isolates of a black fungus from a nasopharyngeal carcinoma patient under radiotherapy, BMC oral health. 2015, 15.
WONG K.W., Kwong D.L.W., Khong P.L., Lee V.H.F., Ng C.Y. and Law W.M., Delineation of Biological Tumor Volume from Positron Emission Tomography Images in Nasopharyngeal Carcinoma, Biomedical Science and Engineering. authors and Scientific Research Publishing Inc., 2014, 7(11): 857-865.
Wang D.D., Ma L., Wong M.P., Lee V.H.F. and Yan H., Contribution of EGFR and ErbB-3 Heterodimerization to the EGFR Mutation-Induced Gefitinib- and Erlotinib-Resistance in Non-Small-Cell Lung Carcinoma Treatments, PLOS ONE. 2015, 10: e0128360.
Wong K.W., Kwong D.L.W., Khong P.L., Lee V.H.F., Ng C.Y. and Law M.W.M., Delineation of Biological Tumor Volume from Positron Emission Tomography Images in Nasopharyngeal Carcinoma., Journal of Biomedical Science and Engineering. 2014.


Researcher : Lee WMA

List of Research Outputs

Blanchard P., Lee W.M.A., Marguet S., Leclercq J., Ng W.T., Ma J., Chan A.T.C., Huang P.Y., Benhamou E., Zhu G., Chua D.T., Chen Y., Mai H.Q., Kwong D.L.W., Cheah S.L., Moon J., Tung Y., Chi K.H., Fountzils G., Zhang L., Hui E.P., Lu T.X., Bourhis J. and Pignon J.P., Chemotherapy and radiotherapy in nasopharyngeal carcinoma: an update of the MAC-NPC meta-analysis, The Lancet Oncology. 2015, 16: 645-655.
Lee W.M.A., Ngan K.C., Tung S.Y., Cheng A., Kwong D.L.W., Lu T.X., Chan A.T.C., Chan L.L.K., Yiu H., Ng W.T., Wong F., Yuen K.T., Yau S., Cheung F.Y., Chan O.S.H., Choi H. and Chappell R., Preliminary results of trial NPC-0501 evaluating the therapeutic gain by changing from concurrent-adjuvant to induction-concurrent chemoradiotherapy, changing from fluorouracil to capecitabine, and changing from conventional to accelerated radiotherapy fr, Cancer. 2015, 121: 1328-1338.


Researcher : Leong ML

List of Research Outputs

Cheung A.K.L., Ip J.C.Y., Chu C.H.A., Cheng Y., Leong M.L., Ko J.M.Y., Shuen W.H., Lung H.L. and Lung M.L., PTPRG suppresses tumor growth and invasion via inhibition of Akt signaling in nasopharyngeal carcinoma, Oncotarget. 2015, 6: 13434-47.


Researcher : Leung TW

List of Research Outputs

Lam K.O., Cheung G., Sze C.K.H., Lee V.H.F., Tsang J.W.H., Choy T.S., Leung T.W. and Kwong D.L.W., The impact of complete metabolic response in the treatment of metastatic colorectal cancer, In: Annals of Oncology, 39th European Society for Medical Oncologist Congress. 2014.
Lee V.H.F., Kwong D.L.W., Lam K.O., Sze C.K.H., Ho P.P.Y., Chan W.L., Leung D.K.C., Wong L.S. and Leung T.W., Comparison of post-treatment plasma EBV DNA with nasopharyngeal biopsy in patients after radical (chemo)radiotherapy for non-metatatic nasopharyngeal cancer., American Society for Radiation Oncology 56th Annual Meeting. San Francisco, USA, American Society for Radiation Oncology, 2014.


Researcher : Li Y

Project Title:Identification of the novel transforming GLI3–MRPL48 fusion gene in non-small-cell lung cancer.
Investigator(s):Li Y, Guan X
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:03/2014
Completion Date:02/2015


List of Research Outputs

Guan X., Chen L., Ma S.K.Y., Li Y. and Liu M., Molecular mechanisms of development and progression of hepatocellular carcinoma, Science and Technology Prize of Higher Education of China (Natural Science, Second-class). 2014.
Li Y., Chan H.M., Chen L., Chow K.K., Guan X., Liu M. and Lin C., Faculty Outstanding Research Output, Faculty of Medicine, The University of Hong Kong. 2014.
SONG Y., Pan G., Chen L., Ma S.K.Y., Zeng T., Chan T.H., Li L., Lian Q., CHOW K.K., Cai X., Li Y., Li Y., Liu M., LI Y., Zhu Y., Wong N., Yuan Y.F., Pei D. and Guan X., Loss of ATOH8 increases stem cell features of hepatocellular carcinoma cells, Gastroenterology. 2015.


Researcher : Liu KY

List of Research Outputs

She W.H., Cheung T.T., Yau T.C.C., Chan A.C.Y., Chok K.S.H., Chu S.K.F., Liu K.Y., Poon R.T.P., Chan S.C., Fan S.T. and Lo C.M., Survival analysis of transarterial radioembolization with yttrium-90 for hepatocellular carcinoma patients with HBV infection, Hepatobiliary Surgery and Nutrition. 2014, 3(4): 185-193.


Researcher : Liu M

Project Title:Investigation of CHD1L downstream targets and their roles in regulating hepatocellular carcinoma differentiation.
Investigator(s):Liu M, Guan X
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:01/2015


List of Research Outputs

Guan X., Chen L., Ma S.K.Y., Li Y. and Liu M., Molecular mechanisms of development and progression of hepatocellular carcinoma, Science and Technology Prize of Higher Education of China (Natural Science, Second-class). 2014.
Li Y., Chan H.M., Chen L., Chow K.K., Guan X., Liu M. and Lin C., Faculty Outstanding Research Output, Faculty of Medicine, The University of Hong Kong. 2014.
Liu M. and Guan X., Allele imbalance in the transcriptome of human hepatocellular carcinoma: stress-induced gene plays a role, Science Proceedings. 2014, 1: 1-2.
Liu M., Awards for Outstanding Research Postgraduate Student, University of Hong Kong. 2014.
Liu M., Dr KP Stephen Chang Gold Medal 2013/2014, University of Hong Kong . 2014.
Liu M., Faculty Outstanding Research Output Award, Faculty of Medicine, University of Hong Kong . 2014.
Liu M., JIANG L. and Guan X., The genetic and epigenetic alterations in human hepatocellular carcinoma: a recent update, Protein & Cell. 2014, 5: 673-691.
Liu M., Young Scientist Award 2014 in Life Science Section, Hong Kong Institute of Science. 2014.
SONG Y., Pan G., Chen L., Ma S.K.Y., Zeng T., Chan T.H., Li L., Lian Q., CHOW K.K., Cai X., Li Y., Li Y., Liu M., LI Y., Zhu Y., Wong N., Yuan Y.F., Pei D. and Guan X., Loss of ATOH8 increases stem cell features of hepatocellular carcinoma cells, Gastroenterology. 2015.
WANG J., Liu M., Chen L., JIANG L., Yuan Y.F. and Guan X., Overexpression of N-terminal kinase like gene promotes tumorigenicity of hepatocellular carcinoma by regulating cell cycle progression and cell motility, Oncotarget. 2015, 6(3): 1618-1630.


Researcher : Lung HL

Project Title:Investigation of the sixth base, 5-hydroxymethylcytosine, in nasopharyngeal carcinoma
Investigator(s):Lung HL
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2013
Completion Date:10/2014


Project Title:The serum amyloid A1 (SAA1) Polymorphisms as Risk Factors in Esophageal Squamous Cell Carcinoma
Investigator(s):Lung HL, Lung ML, Law SYK
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:11/2013


Project Title:Establishment of human nasopharyngeal carcinoma in 3D invasion and angiogenesis organotypic culture to study hypoxia-induced tumor invasion and angiogenesis
Investigator(s):Lung HL
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2014
Completion Date:07/2015


Project Title:The functional role(s) of SAA1 polymorphisms in integrin-focal adhesion kinase-mediated cell adhesion and tumor metastasis
Investigator(s):Lung HL
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2014
Completion Date:07/2015


Project Title:The effects of the IKKbeta-specific inhibitor PS1145 on tumor formation and metastasis in nasopharyngeal carcinoma
Investigator(s):Lung HL, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:02/2015


List of Research Outputs

Cheng Y., Ho R.L.K.Y., Chan K.C., Kan R.J.A., Tung E., Lung H.L., Yau W.L., Cheung A.K.L., Ko J.M.Y., Zhang Z.F., Luo D.Z., Feng Z.B., Chen S., Guan X., Kwong D.L.W., Stanbridge E.J. and Lung M.L., Anti-angiogenic pathway associations of the 3p21.3 mapped BLU gene in nasopharyngeal carcinoma, Oncogene. 2014.
Cheung A.K.L., Ip J.C.Y., Chu C.H.A., Cheng Y., Leong M.L., Ko J.M.Y., Shuen W.H., Lung H.L. and Lung M.L., PTPRG suppresses tumor growth and invasion via inhibition of Akt signaling in nasopharyngeal carcinoma, Oncotarget. 2015, 6: 13434-47.
KAN P.Q.R., Shuen W.H., Lung H.L., Cheung A.K.L., Dai W., Kwong D.L.W., Ng W.T., Lee A.W.M., Yau C.C., Ngan R.K., Tung S. and Lung M.L., NF-κB p65 Subunit Is Modulated by Latent Transforming Growth Factor-β Binding Protein 2 (LTBP2) in Nasopharyngeal Carcinoma HONE1 and HK1 Cells, PLOS ONE. 2015, 10: e0127239.
Lung M.L., Cheung A.K.L., Ko J.M.Y., Lung H.L., Cheng Y. and Dai W., The interplay of host genetic factors and Epstein-Barr virus in the development of nasopharyngeal carcinoma, Chinese Journal of Cancer. 2014, 33: 556-568.
Man O.Y., Lung M.L. and Lung H.L., Regulation of angiogenesis by Serum Amyloid A 1 (SAA1) isoforms via integrin signaling in esophageal squamous cell carcinoma, The 73rd Annual Meeting of the Japanese Cancer Association. Yokohama, Japan. 2014.
SHUEN W.H., KAN P.Q.R., Yu Z., Lung H.L. and Lung M.L., Novel lentiviral-inducible transgene expression systems and versatile single-plasmid reporters for in vitro and in vivo cancer biology studies, Cancer Gene Therapy. 2015, 22: 207-214.


Researcher : Lung ML

Project Title:Candidate tumor suppressor gene, DUSP6, involvement in esophageal and nasopharyngeal carcinomas
Investigator(s):Lung ML
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2009


Project Title:Centre for Nasopharyngeal Carcinoma Research
Investigator(s):Lung ML, Chen H, Chiang AKS, Chua DTT, Khong PL, Kwong DLW, Guan X, Tsao GSW, Wu EX
Department:Clinical Oncology
Source(s) of Funding:Areas of Excellence Scheme
Start Date:01/2010


Project Title:Role of DNAJB6 epithelial-mesenchymal transition in esophageal squamous cell carcinoma tumorigenesis and metastasis
Investigator(s):Lung ML
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2011
Completion Date:09/2014


Project Title:Elucidating the genetic basis for early-age onset nasopharyngeal carcinoma in Hong Kong
Investigator(s):Lung ML, Sham PC, Yang W, Cherny SS, Chiang AKS
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:11/2013


Project Title:Elucidating the functional role of a metastasis-associated extracellular matrix gene, ECM1, in esophageal cancer
Investigator(s):Lung ML
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:11/2013


Project Title:Advances in Nasopharyngeal Carcinoma Studies
Investigator(s):Lung ML
Department:Clinical Oncology
Source(s) of Funding:Croucher Advanced Study Institute
Start Date:11/2014


Project Title:Secretory NID2, a basement membrane protein facilitating cell adhesion, migration, and metastasis in human cancers
Investigator(s):Lung ML
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2015


List of Research Outputs

Chan K.C., Ting C.M., Chan P.S., Lo M.C., Lo K.W., Smyth T., Lee A.W.M., Ng W.T., Tsao G.S.W., Wong R.N., Lung M.L. and Mak N.K., Study of a novel Hsp90 inhibitor AT13387 as potential therapeutic agent in EBV-associated nasopharyngeal carcinoma, 16th International Symposium on EBV and Associated Diseases. Brisbane, Australia. 2014.
Chan K.C., Chan L.S., Ip J.C.Y., Lo C., Yip T.T.C., Ngan R.K.C., Wong R.N.S., Lo K.W., Ng W.T., Lee A.W.M., Tsao G.S.W., Kahn M., Mak N.K. and Lung M.L., Therapeutic targeting of CBP/β-catenin signaling reduces cancer stem-like population and synergistically suppresses growth of EBV-positive nasopharyngeal carcinoma cells with cisplatin, Scientific Reports. 2015, 5: 9979.
Chan Y.K., Zhang H.M., Liu P., Tsao G.S.W., Lung M.L., Mak N.K., Wong R.N. and Yue P.Y., Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins, International Journal of Cancer. 2015, n/a-n/a.
Cheng Y., Ho R.L.K.Y., Chan K.C., Kan R.J.A., Tung E., Lung H.L., Yau W.L., Cheung A.K.L., Ko J.M.Y., Zhang Z.F., Luo D.Z., Feng Z.B., Chen S., Guan X., Kwong D.L.W., Stanbridge E.J. and Lung M.L., Anti-angiogenic pathway associations of the 3p21.3 mapped BLU gene in nasopharyngeal carcinoma, Oncogene. 2014.
Cheng Y., Phoon Y.P., Jin X., Chong S.Y.S., Ip J.C.Y., Wong W.Y. and Lung M.L., Wnt-C59 arrests stemness and suppresses growth of nasopharyngeal carcinoma in mice by inhibiting the Wnt pathway in the tumor microenvironment, Oncotarget. 2015, 6: 14428-39.
Cheung A.K.L., Ip J.C.Y., Chu C.H.A., Cheng Y., Leong M.L., Ko J.M.Y., Shuen W.H., Lung H.L. and Lung M.L., PTPRG suppresses tumor growth and invasion via inhibition of Akt signaling in nasopharyngeal carcinoma, Oncotarget. 2015, 6: 13434-47.
Cheung A.K.L. and Lung M.L., Protein Tyrosine Phosphatase, Receptor Type G regulates Akt Signaling in Nasopharyngeal Carcinoma, 16th International Symposium on EBV and Associated Diseases. Brisbane, Australia. 2014.
Cheung A.K.L. and Lung M.L., Protein tyrosine phosphatase, receptor type G regulates tumorigenicity and invasion via AKT signaling in NPC, 7th International NPC Biannual Meeting. Yogyakarta, Indonesia. 2015.
Cheung A.K.L. and Lung M.L., Small Project Funding - “Functional validation of a novel DUB3 somatic mutation in tumors of NPC” HK$80,000, HKU University Research Committee. 2015.
Dai W., Cheung A.K.L., Ko J.M.Y., Cheng Y., ZHENG H., Kwong D.L.W., Ngan R., Ng W.T., Lee A.W.M., Yau C.C. and Lung M.L., Aberrant methylation at chromosome 6p as novel biomarkers for diagnosis and prognosis of nasopharyngeal carcinoma, 106th American Association of Cancer Research. Philadelphia, Pennsylvania, USA. 2015.
Dai W., Cheung A.K.L., Ko J.M.Y., Cheng Y., Zheng H., Ngan R., Ngan W.T., Lee A.W.M., Yau C.C., Lee V.H.F. and Lung M.L., Comparative methylome analysis in solid tumors reveals aberrant methylation at chromosome 6p in nasopharyngeal carcinoma, Cancer Medicine. 2015, n/a-n/a.
Dai W., ZHENG H., Tang S.M., Sham P.C., Ko J.M.Y., Cheung A.K.L. and Lung M.L., Using Next-generation Whole-Exome Sequencing Approaches to Elucidate the Genetic Basis for Nasopharyngeal Carcinoma , Gorden Research Conference Genomic Instability. 2014.
Ip J.C.Y., Ko J.M.Y., Yu Z., Chan K.W., Lam A.K., Law S.Y.K., Tong D.K.H. and Lung M.L., A Versatile Orthotopic Nude Mouse Model for Study of Esophageal Squamous Cell Carcinoma, In: Dominic Fan, BioMed Research International. New York, USA, Hindawi Publishing Corporation, 2015, 2015.
Ip J.C.Y., Ko J.M.Y., Yu Z., Chan K.W., Lam A.K.Y., Law S.Y.K., Tong D.K.H. and Lung M.L., Establishment of an orthotopic oesophageal squamous cell carcinoma animal model visualised by bioluminescence imaging and recapitulating the tumour-stromal microenvironment, 19th Research Postgraduate Symposium HKU, Hong Kong. 2014.
KAN P.Q.R., Shuen W.H. and Lung M.L., Extracellular matrix protein, LTBP2, regulates the nuclear trafficking of canonical NF-kB p65 to mediate tumor suppressive effect in NPC, 21st Hong Kong International Cancer Congress. Hong Kong, China. 2014.
KAN P.Q.R., Shuen W.H., Lung H.L., Cheung A.K.L., Dai W., Kwong D.L.W., Ng W.T., Lee A.W.M., Yau C.C., Ngan R.K., Tung S. and Lung M.L., NF-κB p65 Subunit Is Modulated by Latent Transforming Growth Factor-β Binding Protein 2 (LTBP2) in Nasopharyngeal Carcinoma HONE1 and HK1 Cells, PLOS ONE. 2015, 10: e0127239.
Ko J.M.Y., Dai W., Wong E.H.W., Kwong D.L.W., Ng W.T., Lee A., Ngan R.K.C., Yau C.C., Tung S. and Lung M.L., Case-control association studies of DNA damage repair genes associated with genetic susceptibility of nasopharyngeal carcinoma , Gordon Research Conference Genomic Instability. 2014.
Ko J.M.Y., Dai W., Wong H.W.E., Kwong D.L.W., Ng W.T., Lee A.W.M., Ngan R.K., Yau C.C., Tung S. and Lung M.L., Cumulative effects of TERT-CLPTM1L and double-strand breaks repair contribute to higher risk for nasopharyngeal carcinoma, Gordon Research Conferences Genomic Instability Hong Kong. 2014.
Ko J.M.Y., Zhang P., Law S.Y.K., Fan Y., Song Y., Zhao X.K., Wong H.W.E., Tang S., Song X., Lung M.L. and Wang L.D., Identity-by-descent approaches identify regions of importance for genetic susceptibility to hereditary esophageal squamous cell carcinoma, Oncology Reports. 2014, 32(2): 860-870.
Ko J.M.Y., Dai W., Kwong D.L.W., Ng W.T., Lee A.W.M., Ngan R.C., Yau C.C., Tung S. and Lung M.L., The genetic susceptibility and prognostic role of TERT-CLPTM1L and dnes in DNA damage pathways in NPC, 7th International NPC Biannual Meeting. Yogyakarta, Indonesia. 2015.
Lung M.L., (Co-I), Research Grant 2015-2017 - “The clinical relevance of telomere attrition and NPC genetic susceptibility” HK$997,845, Health Medical Research Fund. 2015.
Lung M.L., (Co-I), Research Grant 2015-2017 - “The effects of IKKbeta-specific inhibitor PS1145 on tumor formation and metastasis in NPC” HK$1,000,000, Health Medical Research Fund. 2015.
Lung M.L., Advanced Studies Institute, Croucher Foundation. 2015.
Lung M.L., Elucidating the molecular basis for genetic susceptibility to nasopharyngeal carcinoma, Frontiers in Cancer Biology and Drug Discovery, March 12-13, 2015, Hong Kong. 2015.
Lung M.L., Establishment of Tissue Bank for NPC research in Hong Kong, Hong Kong NPC Symposium 2014, Hong Kong. 2014.
Lung M.L., Gordon Research Conference, NPC Research Conference, $19,125 USD (2016, alternative years), 2015.
Lung M.L., Molecular genetic susceptibility to NPC, 7th Chinese National NPC Conference. Hangzhou,Zhijiang, PRC. 2015.
Lung M.L., NPC diagnostics: host and viral markers, 7th International NPC Symposium. Yogyakarta, Indonesia. 2015.
Lung M.L., OncoSeek 2015-2017, HK$860,000, Hong Kong Science Park Incubator program. 2015.
Lung M.L., OncoSeek April 2015-Mar 2016, HK$300,000, Technology Start-up Support Scheme for Universities. 2015.
Lung M.L., OncoSeek Dec 2014-Mar 2015, HK$650,000, Technology Start-up Support Scheme for Universities. 2014.
Lung M.L., Cheung A.K.L., Ko J.M.Y., Lung H.L., Cheng Y. and Dai W., The interplay of host genetic factors and Epstein-Barr virus in the development of nasopharyngeal carcinoma, Chinese Journal of Cancer. 2014, 33: 556-568.
Lung M.L., Using next-generation sequencing approaches to elucidate the molecular basis for genetic susceptibility to nasopharyngeal carcinoma, Advances in EBV and NPC Research, CUHK. 2014.
MAI Z., Lo C.M.M., Xu J., Chan K.P., Wong C.M., Lung M.L. and Lam T.H., Milk consumption and nasopharyngeal carcinoma (NPC): An ecological study in Hong Kong (abstract and poster presentation), 19th Research Postgraduate Symposium, 10-11 December 2014, Hong Kong. Hong Kong, LKS Faculty of Medicine, HKU, 2014.
Man O.Y., Lung M.L. and Lung H.L., Regulation of angiogenesis by Serum Amyloid A 1 (SAA1) isoforms via integrin signaling in esophageal squamous cell carcinoma, The 73rd Annual Meeting of the Japanese Cancer Association. Yokohama, Japan. 2014.
NG H.Y. and Lung M.L., DESC1, a novel tumor suppressor, sensitize cells to apoptosis under serum deprivation and 5-Flurouracil treatment in esophageal squamous cell carcinoma, 21st Hong Kong International Cancer Congress. Hong Kong, China. 2014.
NG H.Y. and Lung M.L., DESC1, a novel tumor suppressor, sensitizes cells to apoptosis in esophageal squamous cell carcinoma, The 73rd Annual Meeting of the Japanese Cancer Association. Yokohama, Japa. 2014.
SHUEN W.H., KAN P.Q.R., Yu Z., Lung H.L. and Lung M.L., Novel lentiviral-inducible transgene expression systems and versatile single-plasmid reporters for in vitro and in vivo cancer biology studies, Cancer Gene Therapy. 2015, 22: 207-214.
Tsao G.S.W., Tsang C.M., Yip Y.L., Lung M.L. and Lo K.W., Biology of EBV infection in nasopharyngeal epithelial cells, 16th International Symposium on EBV and Associated Diseases. Brisbane, Australia. 2014.
YANG X., Dai W., Kwong D.L.W., Szeto C.Y.Y., Wong H.W.E., Ng W.T., Lee A.W.M., Ngan K.C., Yau C.C., Tung S.Y. and Lung M.L., Epigenetic markers for non-invasive early detection of nasopharyngeal carcinoma by methylation-sensitive high resolution melting, International Journal of Cancer. 2014.
Yu Z. and Lung M.L., Small Project Funding - “Functional and mechanistic analysis of PHF11 in ESCC epigenetics” HK$42,256, HKU University Research Committee. 2015.
ZHENG H., Dai W., Tang S.M., Cheung A.K.L., Ko J.M.Y., Sham P.C. and Lung M.L., Unraveling the genetic basis of nasopharyngeal carcinoma using next-generation sequencing approaches, 106th American Association of Cancer Research. Philadelphia, Pennsylvania, USA. 2015.
ZHENG H. and Lung M.L., Whole exome sequencing of nasopharyngeal carcinoma, 19th Research Postgraduate Symposium HKU, Hong Kong. 2014.
Zhang G., Zong J., VERHOEVEN R.J.A., TONG S., Ji M., Cheng W., Lung M.L., Tsao G.S.W., Pan J. and Chen H., Characterization of extracellular secreted Epstein-Barr virus BART microRNAs as serological markers for nasopharyngeal carcinoma diagnosis and treatment, 16th International Symposium On Epstein-barr Virus And Associated Diseases, July 16-19, 2014, Brisbane, Australia. 2014.
Zhang G., Zong J., Lin S.H.A.O.J.U.N., VERHOEVEN R.J.A., TONG S., Chen Y., Ji M., Cheng W., Tsao G.S.W. and Lung M.L., Circulating Epstein-Barr virus microRNAs miR-BART7 and miR-BART13 as biomarkers for nasopharyngeal carcinoma diagnosis and treatment, International Journal of Cancer. 2014, n/a-n/a.


Researcher : Ma SKY

Project Title:Centre for MicroRNA Study - Basic Research and Clinical Potentials in Cancer
Investigator(s):Ma SKY, Wong AST
Department:Pathology
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2012


Project Title:Characterization and clinical evaluation of the metastasis-suppressing function of TP53INP1 in hepatocellular carcinoma
Investigator(s):Ma SKY
Department:Pathology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2012


Project Title:Hepatitis B virus promotes hepatocarcinogenesis through induction of CD133+ cancer stem cells/tumor-initiating cells
Investigator(s):Ma SKY, Guan X
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2013


Project Title:Significance of Annexin A3 in CD133+ Cancer-Initiating Cells-Driven Hepatocellular Carcinoma
Investigator(s):Ma SKY, Chan KW
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2013


Project Title:Outstanding Young Researcher Award 2012-13
Investigator(s):Ma SKY
Department:Anatomy
Source(s) of Funding:Outstanding Young Researcher Award
Start Date:01/2014


Project Title:A multidisciplinary study on hepatic cancer stem cells
Investigator(s):Ma SKY
Department:Anatomy
Source(s) of Funding:Croucher Innovation Awards
Start Date:04/2014


Project Title:The use of anti-annexin A3 monoclonal antibody for the treatment of liver cancer
Investigator(s):Ma SKY
Department:Anatomy
Source(s) of Funding:Seed Funding Programme for Applied Research
Start Date:05/2014
Completion Date:04/2015


Project Title:miR-1246 and Wnt/β-catenin interaction in the control of CD133+ liver cancer stem cells driven hepatocellular carcinoma
Investigator(s):Ma SKY
Department:Anatomy
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2014


Project Title:Regulatory role of microRNA-1246 and Wnt/?catenin pathway interaction in CD133+ liver cancer stem cells-driven hepatocellular carcinoma
Investigator(s):Ma SKY
Department:Anatomy
Source(s) of Funding:Early Career Scheme (ECS)
Start Date:01/2015


Project Title:PRMT6 in the control of glucose metabolic reprogramming in CD133+ liver cancer stem cells
Investigator(s):Ma SKY
Department:Anatomy
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2015


Project Title:A Multidisciplinary Study on CD133 Liver Cancer Stem Cells: Molecular Mechanisms, Clinical Relevance and Therapeutic Implications
Investigator(s):Ma SKY, Guan X, Lo CM, Man K
Department:Anatomy
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2015


List of Research Outputs

Guan X., Chen L., Ma S.K.Y., Li Y. and Liu M., Molecular mechanisms of development and progression of hepatocellular carcinoma, Science and Technology Prize of Higher Education of China (Natural Science, Second-class). 2014.


Researcher : Man OY

List of Research Outputs

Man O.Y., Lung M.L. and Lung H.L., Regulation of angiogenesis by Serum Amyloid A 1 (SAA1) isoforms via integrin signaling in esophageal squamous cell carcinoma, The 73rd Annual Meeting of the Japanese Cancer Association. Yokohama, Japan. 2014.


Researcher : NG HY

List of Research Outputs

NG H.Y. and Lung M.L., DESC1, a novel tumor suppressor, sensitize cells to apoptosis under serum deprivation and 5-Flurouracil treatment in esophageal squamous cell carcinoma, 21st Hong Kong International Cancer Congress. Hong Kong, China. 2014.
NG H.Y. and Lung M.L., DESC1, a novel tumor suppressor, sensitizes cells to apoptosis in esophageal squamous cell carcinoma, The 73rd Annual Meeting of the Japanese Cancer Association. Yokohama, Japa. 2014.


Researcher : Ng CY

List of Research Outputs

WONG K.W., Kwong D.L.W., Khong P.L., Lee V.H.F., Ng C.Y. and Law W.M., Delineation of Biological Tumor Volume from Positron Emission Tomography Images in Nasopharyngeal Carcinoma, Biomedical Science and Engineering. authors and Scientific Research Publishing Inc., 2014, 7(11): 857-865.
Wong K.W., Kwong D.L.W., Khong P.L., Lee V.H.F., Ng C.Y. and Law M.W.M., Delineation of Biological Tumor Volume from Positron Emission Tomography Images in Nasopharyngeal Carcinoma., Journal of Biomedical Science and Engineering. 2014.


Researcher : Ng WT

List of Research Outputs

Blanchard P., Lee W.M.A., Marguet S., Leclercq J., Ng W.T., Ma J., Chan A.T.C., Huang P.Y., Benhamou E., Zhu G., Chua D.T., Chen Y., Mai H.Q., Kwong D.L.W., Cheah S.L., Moon J., Tung Y., Chi K.H., Fountzils G., Zhang L., Hui E.P., Lu T.X., Bourhis J. and Pignon J.P., Chemotherapy and radiotherapy in nasopharyngeal carcinoma: an update of the MAC-NPC meta-analysis, The Lancet Oncology. 2015, 16: 645-655.
Lee W.M.A., Ngan K.C., Tung S.Y., Cheng A., Kwong D.L.W., Lu T.X., Chan A.T.C., Chan L.L.K., Yiu H., Ng W.T., Wong F., Yuen K.T., Yau S., Cheung F.Y., Chan O.S.H., Choi H. and Chappell R., Preliminary results of trial NPC-0501 evaluating the therapeutic gain by changing from concurrent-adjuvant to induction-concurrent chemoradiotherapy, changing from fluorouracil to capecitabine, and changing from conventional to accelerated radiotherapy fr, Cancer. 2015, 121: 1328-1338.
Sze C.K.H., Chan L.L.K., Ng W.T., Hung A.W.M., Lee M.C.H., Chang A.T.Y., Chan O.S.H., Cheung F.Y., Yeung M.W.R. and Lee W.M.A., Should all nasopharyngeal carcinoma with masticator space involvement be staged as T4?, Oral Oncology. 2014, 50.
YANG X., Dai W., Kwong D.L.W., Szeto C.Y.Y., Wong H.W.E., Ng W.T., Lee A.W.M., Ngan K.C., Yau C.C., Tung S.Y. and Lung M.L., Epigenetic markers for non-invasive early detection of nasopharyngeal carcinoma by methylation-sensitive high resolution melting, International Journal of Cancer. 2014.


Researcher : Ngan KC

List of Research Outputs

Lee W.M.A., Ngan K.C., Tung S.Y., Cheng A., Kwong D.L.W., Lu T.X., Chan A.T.C., Chan L.L.K., Yiu H., Ng W.T., Wong F., Yuen K.T., Yau S., Cheung F.Y., Chan O.S.H., Choi H. and Chappell R., Preliminary results of trial NPC-0501 evaluating the therapeutic gain by changing from concurrent-adjuvant to induction-concurrent chemoradiotherapy, changing from fluorouracil to capecitabine, and changing from conventional to accelerated radiotherapy fr, Cancer. 2015, 121: 1328-1338.
YANG X., Dai W., Kwong D.L.W., Szeto C.Y.Y., Wong H.W.E., Ng W.T., Lee A.W.M., Ngan K.C., Yau C.C., Tung S.Y. and Lung M.L., Epigenetic markers for non-invasive early detection of nasopharyngeal carcinoma by methylation-sensitive high resolution melting, International Journal of Cancer. 2014.


Researcher : Phoon YP

List of Research Outputs

Cheng Y., Phoon Y.P., Jin X., Chong S.Y.S., Ip J.C.Y., Wong W.Y. and Lung M.L., Wnt-C59 arrests stemness and suppresses growth of nasopharyngeal carcinoma in mice by inhibiting the Wnt pathway in the tumor microenvironment, Oncotarget. 2015, 6: 14428-39.


Researcher : SHUEN WH

List of Research Outputs

Cheung A.K.L., Ip J.C.Y., Chu C.H.A., Cheng Y., Leong M.L., Ko J.M.Y., Shuen W.H., Lung H.L. and Lung M.L., PTPRG suppresses tumor growth and invasion via inhibition of Akt signaling in nasopharyngeal carcinoma, Oncotarget. 2015, 6: 13434-47.
KAN P.Q.R., Shuen W.H. and Lung M.L., Extracellular matrix protein, LTBP2, regulates the nuclear trafficking of canonical NF-kB p65 to mediate tumor suppressive effect in NPC, 21st Hong Kong International Cancer Congress. Hong Kong, China. 2014.
KAN P.Q.R., Shuen W.H., Lung H.L., Cheung A.K.L., Dai W., Kwong D.L.W., Ng W.T., Lee A.W.M., Yau C.C., Ngan R.K., Tung S. and Lung M.L., NF-κB p65 Subunit Is Modulated by Latent Transforming Growth Factor-β Binding Protein 2 (LTBP2) in Nasopharyngeal Carcinoma HONE1 and HK1 Cells, PLOS ONE. 2015, 10: e0127239.
SHUEN W.H., KAN P.Q.R., Yu Z., Lung H.L. and Lung M.L., Novel lentiviral-inducible transgene expression systems and versatile single-plasmid reporters for in vitro and in vivo cancer biology studies, Cancer Gene Therapy. 2015, 22: 207-214.


Researcher : SONG Y

List of Research Outputs

SONG Y., Pan G., Chen L., Ma S.K.Y., Zeng T., Chan T.H., Li L., Lian Q., CHOW K.K., Cai X., Li Y., Li Y., Liu M., LI Y., Zhu Y., Wong N., Yuan Y.F., Pei D. and Guan X., Loss of ATOH8 increases stem cell features of hepatocellular carcinoma cells, Gastroenterology. 2015.


Researcher : Shuen WH

List of Research Outputs

Cheung A.K.L., Ip J.C.Y., Chu C.H.A., Cheng Y., Leong M.L., Ko J.M.Y., Shuen W.H., Lung H.L. and Lung M.L., PTPRG suppresses tumor growth and invasion via inhibition of Akt signaling in nasopharyngeal carcinoma, Oncotarget. 2015, 6: 13434-47.
KAN P.Q.R., Shuen W.H. and Lung M.L., Extracellular matrix protein, LTBP2, regulates the nuclear trafficking of canonical NF-kB p65 to mediate tumor suppressive effect in NPC, 21st Hong Kong International Cancer Congress. Hong Kong, China. 2014.
KAN P.Q.R., Shuen W.H., Lung H.L., Cheung A.K.L., Dai W., Kwong D.L.W., Ng W.T., Lee A.W.M., Yau C.C., Ngan R.K., Tung S. and Lung M.L., NF-κB p65 Subunit Is Modulated by Latent Transforming Growth Factor-β Binding Protein 2 (LTBP2) in Nasopharyngeal Carcinoma HONE1 and HK1 Cells, PLOS ONE. 2015, 10: e0127239.
SHUEN W.H., KAN P.Q.R., Yu Z., Lung H.L. and Lung M.L., Novel lentiviral-inducible transgene expression systems and versatile single-plasmid reporters for in vitro and in vivo cancer biology studies, Cancer Gene Therapy. 2015, 22: 207-214.


Researcher : Soong SI

List of Research Outputs

Lam W.W.T., Yeo W., Suen J., Ho W.M., Tsang J.W.H., Soong S.I., Yau T.K., Wong K.Y., Sze W.K., Ng A.W., Kwong A., Suen T.K.D., Fong D.Y.T., Ho S. and Fielding R., Goal adjustment influence on psychological well-being following advanced breast cancer diagnosis, Psycho-Oncology. 2015, Epub on 2015-6-18.


Researcher : Sze CKH

Project Title:Feasibility and prognostic impact of DNA repair gene profiling by PCR array in locally advanced nasopharyngeal carcinoma treated with radiotherapy alone or in conjunction with chemoradiotherapy.
Investigator(s):Sze CKH, Kwong DLW, Lung ML, Lung HL, Lee WMA, Lee VHF, Lam KO
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:11/2013


Project Title:The 16th International Symposium on EBV and Associated Diseases ; Advances in the Clinical Management of Nasopharyngeal Cancer
Investigator(s):Sze CKH
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:07/2014
Completion Date:07/2014


List of Research Outputs

Lai V., Lee V.H.F., Lam K.O., Sze C.K.H., Chan Q.U.E.E.N.I.E. and Khong P.L., Intravoxel water diffusion heterogeneity MR imaging of nasopharyngeal carcinoma using stretched exponential diffusion model, European Radiology. 2014.
Lam K.O., Cheung G., Sze C.K.H., Lee V.H.F., Tsang J.W.H., Choy T.S., Leung T.W. and Kwong D.L.W., The impact of complete metabolic response in the treatment of metastatic colorectal cancer, In: Annals of Oncology, 39th European Society for Medical Oncologist Congress. 2014.
Lee A.W.M., Sze C.K.H., Lam K.O. and Chen X., A tale of two cities in China: Hong Kong and Shenzhen, In: Anthony L Zietman, International Journal of Radiation Oncology, Biology and Physics. Elsevier Inc, 2014, 89: 704-708.
Lee V.H.F., Kwong D.L.W., Lam K.O., Sze C.K.H., Ho P.P.Y., Chan W.L., Leung D.K.C., Wong L.S. and Leung T.W., Comparison of post-treatment plasma EBV DNA with nasopharyngeal biopsy in patients after radical (chemo)radiotherapy for non-metatatic nasopharyngeal cancer., American Society for Radiation Oncology 56th Annual Meeting. San Francisco, USA, American Society for Radiation Oncology, 2014.
Sze C.K.H. and Lee A.W.M., Advances in the Clinical Management of Nasopharyngeal Cancer, 16th International Symposium on EBV and associated diseases. 2014.
Sze C.K.H., Lam K.O. and Lee A.W.M., Early Stage Nasopharyngeal Carcinoma, In: Lauren Constable, Nasopharyngeal Carcinoma: management strategies. Future Medince, 2014.
Sze C.K.H., Geriatric Oncology: An Emerging Health Issue and Unmet Need. , Multi-specialty Medical Mega Conference Fifth Round.. 2015.
Sze C.K.H., Chan L.L.K., Ng W.T., Hung A.W.M., Lee M.C.H., Chang A.T.Y., Chan O.S.H., Cheung F.Y., Yeung M.W.R. and Lee W.M.A., Should all nasopharyngeal carcinoma with masticator space involvement be staged as T4?, Oral Oncology. 2014, 50.
Sze C.K.H., Stereotatic radiotherapy for spinal tumours , Combined Hong Kong International Orthopaedic Forum. . 2015.
Sze C.K.H., Targeting the mTOR Pathway for Endocrine Responsive Breast Cancer , The 28th Annual Convention of Philippine Society of Medical Oncology. 2014.


Researcher : Szeto CYY

List of Research Outputs

YANG X., Dai W., Kwong D.L.W., Szeto C.Y.Y., Wong H.W.E., Ng W.T., Lee A.W.M., Ngan K.C., Yau C.C., Tung S.Y. and Lung M.L., Epigenetic markers for non-invasive early detection of nasopharyngeal carcinoma by methylation-sensitive high resolution melting, International Journal of Cancer. 2014.


Researcher : Tsang JWH

Project Title:Breast Cancer Awareness, Spectrum of Breast Cancer with Particular Reference to Triple Negative Breast Cancer in the Hong Kong Chinese Population
Investigator(s):Tsang JWH, Chua DTT, Kwong A, Khoo US, Lam WWT
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:10/2008


Project Title:Training Oncology Interns in Patient-centred Communication
Investigator(s):Tsang JWH, Lam WWT, Fielding R
Department:Clinical Oncology
Source(s) of Funding:Hong Kong Cancer Fund - General Award
Start Date:04/2011


Project Title:General Awareness and Attitudes towards Cancer Clinical Trials among Cancer Patients in Hong Kong.
Investigator(s):Tsang JWH, Yung ST, Lam WWT
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:04/2011


Project Title:Study of the OncotypeDx 21-gene assay and its impact on the treatment decision making process among Hong Kong Chinese breast cancer patients
Investigator(s):Tsang JWH, Khoo US
Department:Clinical Oncology
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:08/2012


Project Title:Personalized Medicine for Elderly Breast Cancer Patients (CRF)
Investigator(s):Tsang JWH
Department:Clinical Oncology
Source(s) of Funding:Seed Funding for Incubating Group-based Collaborative Research Projects
Start Date:01/2015


List of Research Outputs

Khongkow P., Karunarathna U., Khongkow M., Gong C., Gomes A.R., Yague E., Monteiro L.J., Kongsema M., Zona S., Man P.S., Tsang J.W.H., Coombes R.C., Wu K.J., Khoo U.S., Medema R.H., Freire R. and Lam E.W., FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance, Oncogene. 2014, 33(32): 4144-55.
Khongkow P., Gomes A.R., Gong C., Man P.S., Tsang J.W.H., Zhao F., Monteiro L.J., Coombes R.C., Medema R.H., Khoo U.S. and Lam E.W., Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast cancer paclitaxel resistance, Oncogene. 2015.
Kwan S.K.J., Tsang J.W.H., Chan F.H.W. and Yau S.Z.M., Humanism in Aging: Intergenerational and Experiential Learning in the Community ($100,000), Development Fund for Medical Humanities, LKS Faculty of Medicine (HKU). 2015.
Lam K.O., Cheung G., Sze C.K.H., Lee V.H.F., Tsang J.W.H., Choy T.S., Leung T.W. and Kwong D.L.W., The impact of complete metabolic response in the treatment of metastatic colorectal cancer, In: Annals of Oncology, 39th European Society for Medical Oncologist Congress. 2014.
Lam W.W.T., Yeo W., Suen J., Ho W.M., Tsang J.W.H., Soong S.I., Yau T.K., Wong K.Y., Sze W.K., Ng A.W., Kwong A., Suen T.K.D., Fong D.Y.T., Ho S. and Fielding R., Goal adjustment influence on psychological well-being following advanced breast cancer diagnosis, Psycho-Oncology. 2015, Epub on 2015-6-18.
Lam W.W.T., Ng J., Tsang J.W.H., Yau T.K., Soong I., Yeo W., Suen J., Ho W.M., Wong K.Y., Kwong A., Suen T.K.D., Sze W.K. and Ng A., Trajectory patterns of supportive care needs among Chinese women with advanced breast cancer, IPOS 15th World Congress. 2014.
Wong G.T.C., Jenkins C.R., Tsang J.W.H., Chen J.Y., Chan L.C. and Tanner J.A., Finalist for Best Free Communication , Asia Pacific Medical Education Conference. 2015.
Wong G.T.C., Jenkins C.R., Tsang J.W.H., Chen J.Y., Chan L.C. and Tanner J.A., Use of film to build student empathy and enable reflective thought in a new Medical Humanities programme embedded within the undergraduate MBBS curriculum., 12th Asia Pacific Medical Education Conference, Singapore (awarded Finalist prize in the Free Communication Session) (2015). 2015.
Wong G.T.C., Jenkins C.R., Tsang J.W.H., Chen J.Y., Chan L.C. and Tanner J.A., Use of film to build student empathy and enable reflective thought, Asia Pacific Medical Education Conference. 2015.
Wong O.L., Tsang J.W.H., Cowling B.J. and Leung G.M., Optimizing resource allocation for breast cancer prevention and care among Hong Kong Chinese women: A generalized cost-effectiveness analysis (abstract), Health Research Symposium 2014, 15 November 2014, Hong Kong. Hong Kong, Food and Health Bureau, HKSAR, 2014, 72.


Researcher : Tung E

List of Research Outputs

Cheng Y., Ho R.L.K.Y., Chan K.C., Kan R.J.A., Tung E., Lung H.L., Yau W.L., Cheung A.K.L., Ko J.M.Y., Zhang Z.F., Luo D.Z., Feng Z.B., Chen S., Guan X., Kwong D.L.W., Stanbridge E.J. and Lung M.L., Anti-angiogenic pathway associations of the 3p21.3 mapped BLU gene in nasopharyngeal carcinoma, Oncogene. 2014.


Researcher : WANG J

List of Research Outputs

WANG J., Liu M., Chen L., JIANG L., Yuan Y.F. and Guan X., Overexpression of N-terminal kinase like gene promotes tumorigenicity of hepatocellular carcinoma by regulating cell cycle progression and cell motility, Oncotarget. 2015, 6(3): 1618-1630.


Researcher : WONG KW

List of Research Outputs

WONG K.W., Kwong D.L.W., Khong P.L., Lee V.H.F., Ng C.Y. and Law W.M., Delineation of Biological Tumor Volume from Positron Emission Tomography Images in Nasopharyngeal Carcinoma, Biomedical Science and Engineering. authors and Scientific Research Publishing Inc., 2014, 7(11): 857-865.
Wong K.W., Kwong D.L.W., Khong P.L., Lee V.H.F., Ng C.Y. and Law M.W.M., Delineation of Biological Tumor Volume from Positron Emission Tomography Images in Nasopharyngeal Carcinoma., Journal of Biomedical Science and Engineering. 2014.


Researcher : Wong HWE

List of Research Outputs

Ko J.M.Y., Dai W., Wong H.W.E., Kwong D.L.W., Ng W.T., Lee A.W.M., Ngan R.K., Yau C.C., Tung S. and Lung M.L., Cumulative effects of TERT-CLPTM1L and double-strand breaks repair contribute to higher risk for nasopharyngeal carcinoma, Gordon Research Conferences Genomic Instability Hong Kong. 2014.
Ko J.M.Y., Zhang P., Law S.Y.K., Fan Y., Song Y., Zhao X.K., Wong H.W.E., Tang S., Song X., Lung M.L. and Wang L.D., Identity-by-descent approaches identify regions of importance for genetic susceptibility to hereditary esophageal squamous cell carcinoma, Oncology Reports. 2014, 32(2): 860-870.
YANG X., Dai W., Kwong D.L.W., Szeto C.Y.Y., Wong H.W.E., Ng W.T., Lee A.W.M., Ngan K.C., Yau C.C., Tung S.Y. and Lung M.L., Epigenetic markers for non-invasive early detection of nasopharyngeal carcinoma by methylation-sensitive high resolution melting, International Journal of Cancer. 2014.


Researcher : Wong KW

List of Research Outputs

WONG K.W., Kwong D.L.W., Khong P.L., Lee V.H.F., Ng C.Y. and Law W.M., Delineation of Biological Tumor Volume from Positron Emission Tomography Images in Nasopharyngeal Carcinoma, Biomedical Science and Engineering. authors and Scientific Research Publishing Inc., 2014, 7(11): 857-865.
Wong K.W., Kwong D.L.W., Khong P.L., Lee V.H.F., Ng C.Y. and Law M.W.M., Delineation of Biological Tumor Volume from Positron Emission Tomography Images in Nasopharyngeal Carcinoma., Journal of Biomedical Science and Engineering. 2014.


Researcher : Wong WY

List of Research Outputs

Cheng Y., Phoon Y.P., Jin X., Chong S.Y.S., Ip J.C.Y., Wong W.Y. and Lung M.L., Wnt-C59 arrests stemness and suppresses growth of nasopharyngeal carcinoma in mice by inhibiting the Wnt pathway in the tumor microenvironment, Oncotarget. 2015, 6: 14428-39.


Researcher : Wu VWC

List of Research Outputs

Cheng S.C., Wu V.W.C., Kwong D.L.W., Lui C.Y., Cheng C.K., Kot B.C. and Ying M.T., Sonographic appearance of thyroid glands in patients treated with intensity-modulated radiotherapy or conventional radiotherapy for nasopharyngeal carcinoma , Journal of Clinical Ultrasound . 2014 Wiley Periodicals, Inc., 2014.
Cheuk I.W., Yip S.P., Kwong D.L.W. and Wu V.W.C., Association of XRCC1 and XRCC3 gene haplotypes with the development of radiation-induced fibrosis in patients with nasopharyngeal carcinoma., Molecular and Clinical Oncology. 2014.
Yuan C., Wu V.W.C., Yip S.P., Kwong D.L.W., Ying M. and Feng Y., Predictors of the Extent of Carotid Atherosclerosis in Patients Treated with Radiotherapy for Nasopharyngeal Carcinoma, PLoS ONE. 2014, 9: e116284.
Yuan C., Wu V.W.C., Yip S.P., Kwong D.L.W. and Ying M., Ultrasound Evaluation of Carotid Atherosclerosis in Post-Radiotherapy Nasopharyngeal Carcinoma Patients, Type 2 Diabetics, and Healthy Controls., Ultraschall Med. 2015.


Researcher : YANG X

List of Research Outputs

YANG X., Dai W., Kwong D.L.W., Szeto C.Y.Y., Wong H.W.E., Ng W.T., Lee A.W.M., Ngan K.C., Yau C.C., Tung S.Y. and Lung M.L., Epigenetic markers for non-invasive early detection of nasopharyngeal carcinoma by methylation-sensitive high resolution melting, International Journal of Cancer. 2014.


Researcher : Yau CC

List of Research Outputs

YANG X., Dai W., Kwong D.L.W., Szeto C.Y.Y., Wong H.W.E., Ng W.T., Lee A.W.M., Ngan K.C., Yau C.C., Tung S.Y. and Lung M.L., Epigenetic markers for non-invasive early detection of nasopharyngeal carcinoma by methylation-sensitive high resolution melting, International Journal of Cancer. 2014.


Researcher : Yau TK

List of Research Outputs

Lam W.W.T., Yeo W., Suen J., Ho W.M., Tsang J.W.H., Soong S.I., Yau T.K., Wong K.Y., Sze W.K., Ng A.W., Kwong A., Suen T.K.D., Fong D.Y.T., Ho S. and Fielding R., Goal adjustment influence on psychological well-being following advanced breast cancer diagnosis, Psycho-Oncology. 2015, Epub on 2015-6-18.


Researcher : Yeung MWR

List of Research Outputs

Sze C.K.H., Chan L.L.K., Ng W.T., Hung A.W.M., Lee M.C.H., Chang A.T.Y., Chan O.S.H., Cheung F.Y., Yeung M.W.R. and Lee W.M.A., Should all nasopharyngeal carcinoma with masticator space involvement be staged as T4?, Oral Oncology. 2014, 50.


Researcher : Yu Z

Project Title:Functional and mechanistic analysis of PHF11 in esophageal squamous cell carcinoma epigenetics
Investigator(s):Yu Z, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:03/2015


List of Research Outputs

Ip J.C.Y., Ko J.M.Y., Yu Z., Chan K.W., Lam A.K., Law S.Y.K., Tong D.K.H. and Lung M.L., A Versatile Orthotopic Nude Mouse Model for Study of Esophageal Squamous Cell Carcinoma, In: Dominic Fan, BioMed Research International. New York, USA, Hindawi Publishing Corporation, 2015, 2015.
Ip J.C.Y., Ko J.M.Y., Yu Z., Chan K.W., Lam A.K.Y., Law S.Y.K., Tong D.K.H. and Lung M.L., Establishment of an orthotopic oesophageal squamous cell carcinoma animal model visualised by bioluminescence imaging and recapitulating the tumour-stromal microenvironment, 19th Research Postgraduate Symposium HKU, Hong Kong. 2014.
SHUEN W.H., KAN P.Q.R., Yu Z., Lung H.L. and Lung M.L., Novel lentiviral-inducible transgene expression systems and versatile single-plasmid reporters for in vitro and in vivo cancer biology studies, Cancer Gene Therapy. 2015, 22: 207-214.
Yu Z. and Lung M.L., Small Project Funding - “Functional and mechanistic analysis of PHF11 in ESCC epigenetics” HK$42,256, HKU University Research Committee. 2015.


Researcher : Yuen KT

List of Research Outputs

Lee W.M.A., Ngan K.C., Tung S.Y., Cheng A., Kwong D.L.W., Lu T.X., Chan A.T.C., Chan L.L.K., Yiu H., Ng W.T., Wong F., Yuen K.T., Yau S., Cheung F.Y., Chan O.S.H., Choi H. and Chappell R., Preliminary results of trial NPC-0501 evaluating the therapeutic gain by changing from concurrent-adjuvant to induction-concurrent chemoradiotherapy, changing from fluorouracil to capecitabine, and changing from conventional to accelerated radiotherapy fr, Cancer. 2015, 121: 1328-1338.


Researcher : ZHENG H

List of Research Outputs

Dai W., Cheung A.K.L., Ko J.M.Y., Cheng Y., ZHENG H., Kwong D.L.W., Ngan R., Ng W.T., Lee A.W.M., Yau C.C. and Lung M.L., Aberrant methylation at chromosome 6p as novel biomarkers for diagnosis and prognosis of nasopharyngeal carcinoma, 106th American Association of Cancer Research. Philadelphia, Pennsylvania, USA. 2015.
Dai W., Cheung A.K.L., Ko J.M.Y., Cheng Y., Zheng H., Ngan R., Ngan W.T., Lee A.W.M., Yau C.C., Lee V.H.F. and Lung M.L., Comparative methylome analysis in solid tumors reveals aberrant methylation at chromosome 6p in nasopharyngeal carcinoma, Cancer Medicine. 2015, n/a-n/a.
Dai W., ZHENG H., Tang S.M., Sham P.C., Ko J.M.Y., Cheung A.K.L. and Lung M.L., Using Next-generation Whole-Exome Sequencing Approaches to Elucidate the Genetic Basis for Nasopharyngeal Carcinoma , Gorden Research Conference Genomic Instability. 2014.
ZHENG H., Dai W., Tang S.M., Cheung A.K.L., Ko J.M.Y., Sham P.C. and Lung M.L., Unraveling the genetic basis of nasopharyngeal carcinoma using next-generation sequencing approaches, 106th American Association of Cancer Research. Philadelphia, Pennsylvania, USA. 2015.
ZHENG H. and Lung M.L., Whole exome sequencing of nasopharyngeal carcinoma, 19th Research Postgraduate Symposium HKU, Hong Kong. 2014.


Researcher : Zhang L

List of Research Outputs

Li B., Li J., Xu W., Guan X., Qin Y.R., Zhang L., Law S.Y.K., Tsao G.S.W. and Cheung A., Suppression of esophageal tumor growth and chemoresistance by directly targeting the PI3K/AKT pathway, Oncotarget. 2014, 5(22): 11576-11587.


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