Dept of Physiology

DEPT OF PHYSIOLOGY

Researcher : Ballard HJ

Project Title:	Involvement of connexin hemichannels in ATP release from skeletal muscle
Investigator(s):	Ballard HJ
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013
Completion Date:	04/2015

Project Title:	ATP release from vascular endothelium and erythrocytes during skeletal muscle contraction
Investigator(s):	Ballard HJ
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

Project Title:	1st Annual International Conference on Advanced Research: Physiology (ARP 2014); Involvement of the Cystic Fibrosis Transmembrane Conductance Regulator and Pannexins in ATP Release from Contracting Skeletal Muscles
Investigator(s):	Ballard HJ
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2014
Completion Date:	07/2014

Project Title:	Involvement of Pannexin 1 in CFTR-regulated ATP release from skeletal muscle
Investigator(s):	Ballard HJ
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2015

List of Research Outputs

Le G.Y., Essackjee H.C. and Ballard H.J., Intracellular adenosine formation and release by freshly-isolated vascular endothelial cells from rat skeletal muscle: effects of hypoxia and/or acidosis, Biochemical and Biophysical Research Communications. 2014, 450: 93-98.

Researcher : Bourreau JP

Project Title:	Role of cyclooxygenase in the ventricular effects of adrenomedullin: does prostacyclin contribute towards the cardiodepression in the late hypodynamic phase of septic shock?
Investigator(s):	Bourreau JP
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	Endothelim-dependent hyperpolarization and relaxation of vascular smooth muscle: influence of the mode of excitation-coupling of vasoconstrictors
Investigator(s):	Bourreau JP
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2005

Project Title:	Switch in G-protein coupling. Role of intracellular cAMP
Investigator(s):	Bourreau JP
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2006

Researcher : Bu L

Project Title:	Investigation of the relationship between ISL1+ and WT1+ heart progenitor cells in humans
Investigator(s):	Bu L, Li RA
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

Project Title:	Study of cardiomyopathy through genome editing in human pluripotent stem cells
Investigator(s):	Bu L, Li RA
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013
Completion Date:	12/2014

Researcher : CHEN G

List of Research Outputs

CHEN G., LI S., Karakikes I., Ren L., Chow M.Z.Y., Chopra A., Keung W.W.Y., Yan B., Chan C.W.Y., Costa K.D., Kong M.C.W., Hajjar R.J., Chen C.S. and Li R.A., Phospholamban as a Crucial Determinant of the Inotropic Response of Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes and Engineered 3D Tissue Constructs, Circulation: Arrhythmia and Electrophysiology. 2014.

Researcher : CHEN W

List of Research Outputs

CHEN W., Ma C.W., DE NOGUEIRA BOTELHO F.P., HU H., LAM T.F., Lai C.H., Shum D.K.Y. and Chan Y.S., Early postnatal perturbation of inhibitory transmission in the vestibular nucleus governs the expression of spatial map and spatial navigation behaviors, Abstracts of 10th Int’l Symp. on Healthy Aging: 55. 2015.

CHEN W., Ma C.W., DE NOGUEIRA BOTELHO F.P., NG K.P., HU H., Bai Z.T., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of inhibitory transmission in the vestibular nucleus during an early postnatal stage impacts on the thalamic spatial map and spatial cognitive behaviors., Proc. 16^th Conference of Neuropsychopharamcology Wenzhou. September 25-28, 2014]. 2014.

JIANG Q., Ma C.W., CHEN W., Shum D.K.Y. and Chan Y.S., Effects of fluoxetine on the restoration of plasticity in young adult vestibular nucleus, Abstracts of 10th Int’l Symp. on Healthy Aging: 80. 2015.

Researcher : Cai S

List of Research Outputs

Cai S., Chan Y.S. and Shum D.K.Y., Derivation of stable Schwann cells from human bone marrow stromal cells. Journal of Neurochemistry, 130 Suppl 1 26, [ 11^th Biennial Meeting of Asia-Pacific Society for Neurochemistry Kaohsiung, Taiwan. August 23-26, 2014]. 2014.

Cai S., Chan Y.S. and Shum D.K.Y., Directed differentiation of human induced pluripotent stem cell to sensory neurons by combined small molecule inhibitors, Soc. Neuroscience Abstract (USA) 397.12/B15. 2014.

Cai S., Chan Y.S. and Shum D.K.Y., Small molecule approach to direct differentiation of human induced pluripotent stem cells to sensory neurons, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 79. 2015.

Researcher : Chan YS

Project Title:	30th Annual Conference of Society for Neuroscience Expression of N-Methyl-D-Aspartate Receptor Subunits and Induction of c-fos in Otolith Neurons in the Vestibular Nuclei of Postnatal Rats
Investigator(s):	Chan YS
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2000

Project Title:	31st Annual Meeting of Society for Neuroscience Expression of Neurotrophin Receptors in Vestibular Nuclei During the Postnatal Development of the Rat
Investigator(s):	Chan YS
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2001

Project Title:	XXIV Annual Conference of Indian Academy of Neurosciences Development Refinement of Spatial Recognition Circuits
Investigator(s):	Chan YS
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	12/2006

Project Title:	Role of the thalamus in integrating spatial information and guiding navigation
Investigator(s):	Chan YS
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2009

Project Title:	Outstanding Research Student Supervisor Award 2009-10
Investigator(s):	Chan YS
Department:	Physiology
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	12/2010

Project Title:	Vestibular nuclear signals regulate the postnatal development of a thalamic network for spatial navigation
Investigator(s):	Chan YS, Shum DKY
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2011

Project Title:	Long-term depression of inhibitory responses is critical to the maturation of the vestibular circuitry
Investigator(s):	Chan YS, Shum DKY
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2012

Project Title:	Serotonin-induced bidirectional modulation of activity-dependent synaptic plasticity tunes vestibular functions
Investigator(s):	Chan YS, Shum DKY
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2013

Project Title:	Neuroscience 2014; Glutamergic transmission in the vestibular nucleus is critical to the formation of spatial topography and acquisition of spatial navigation in rats
Investigator(s):	Chan YS
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2014
Completion Date:	11/2014

Project Title:	Orexin-induced modulation of activity-dependent synaptic plasticity is critical for the maturation of vestibular circuitry and functions
Investigator(s):	Chan YS, Shum DKY, Lai CH
Department:	Physiology
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2015

List of Research Outputs

CHEN W., Ma C.W., DE NOGUEIRA BOTELHO F.P., HU H., LAM T.F., Lai C.H., Shum D.K.Y. and Chan Y.S., Early postnatal perturbation of inhibitory transmission in the vestibular nucleus governs the expression of spatial map and spatial navigation behaviors, Abstracts of 10th Int’l Symp. on Healthy Aging: 55. 2015.

CHEN W., Ma C.W., DE NOGUEIRA BOTELHO F.P., NG K.P., HU H., Bai Z.T., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of inhibitory transmission in the vestibular nucleus during an early postnatal stage impacts on the thalamic spatial map and spatial cognitive behaviors., Proc. 16^th Conference of Neuropsychopharamcology Wenzhou. September 25-28, 2014]. 2014.

Cai S., Chan Y.S. and Shum D.K.Y., Derivation of stable Schwann cells from human bone marrow stromal cells. Journal of Neurochemistry, 130 Suppl 1 26, [ 11^th Biennial Meeting of Asia-Pacific Society for Neurochemistry Kaohsiung, Taiwan. August 23-26, 2014]. 2014.

Cai S., Chan Y.S. and Shum D.K.Y., Directed differentiation of human induced pluripotent stem cell to sensory neurons by combined small molecule inhibitors, Soc. Neuroscience Abstract (USA) 397.12/B15. 2014.

Cai S., Chan Y.S. and Shum D.K.Y., Small molecule approach to direct differentiation of human induced pluripotent stem cells to sensory neurons, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 79. 2015.

Chan Y.S., Challenges to medical education in the millennium: From Integration to Humanities, [10^th Congress of Medical Science Education Higher Education Association of China. Changchun, Jilin. August 7-10, 2014]. 2014.

Chan Y.S., Developmental plasticity of vestibular circuits regulates the behavioral outcome of spatial coding. Proc. IBRO-TIFR Neuroscience Symposium, p. 5., [1^st IBRO-APRC Global Advocacy Workshop . Mumbai, India. February 3-4, 2015]. 2015.

Chan Y.S., Developmental plasticity of vestibular circuits regulates the behavioral outcome of spatial coding, [IBRO-APRC Global Advocacy Workshop. Mumbai, India. Feb. 3-4, 2015]. 2015.

Chan Y.S., Ma C.W., Ng K.P., Han L. and Shum D.K.Y., Glutamatergic transmission in the vestibular nucleus is critical to the formation of spatial topography and acquisition of spatial navigation in rats behaviour, Society Neuroscience Abstract (USA), 157.01/EE3. 2014.

Chan Y.S., Ma C.W., Ng K.P., Han L. and Shum D.K.Y., Glutamatergic transmission in the vestibular nucleus is critical to the formation of spatial topography and acquisition of spatial navigation in rats, Soc. Neuroscience Abstract (USA) 157.01/EE3 [Washington DC. Nov. 15-19, 2014]. 2014.

Chan Y.S., Plasticity of the neural network for spatial recognition, [International Conference on Advanced Research: Physiology. Singapore. July 21-22, 2014]. 2014.

Chan Y.S., The developmental origin of directional map in the brain, Proc. of the Joint 2015 Forum of Biotechnology, Medicine and Molecular Evolution and the 12^th Frontier Symposium of Biomedical Sciences, p.51. [Taipei, Taiwan. May 29-30, 2015]. 2015.

Chan Y.S., The developmental origin of directional map in the brain, [Joint 2015 Forum of Biotechnology, Medicine and Molecular Evolution and the 12^th Frontier Symposium of Biomedical Sciences. Taipei, Taiwan. May 29-30, 2015]. 2015.

Chen C.W., Ma C.W., DE NOGUEIRA BOTELHO F.P., HU H., Lam T.F., Lai C.H., Shum D.K.Y. and Chan Y.S., Early postnatal perturbation of inhibitory transmission the vestibular nucleus governs the expression of spatial map and spatial navigation behaviors, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 55. [HK. March 7-8, 2015]. 2015.

Chow G.W., Cham W.C., Chan Y.S. and Shum D.K.Y., Role of proheparanase in regulating synaptic plasticity in rat hippocampus, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 77. 2015.

Han L., Yanagawa Y. and Chan Y.S., Functional identification of GABAergic medial vestibular neurons in VGAT-Venus transgenic mice, Soc. Neuroscience Abstract (USA) 157.02/EE4. 2014.

Han L., Yanagawa Y. and Chan Y.S., Intrinsic membrane properties of neurons in medial vestibular nucleus of VGAT-Venus transgenic mice, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 75. 2015.

Han L., Lai S.K., Lai C.H. and Chan Y.S., Serotoninergic control of synaptic transmission in rat medial vestibular nucleus, Journal of Neurochemistry , 130 Suppl 1 : 28. [11^th Biennial Meeting of Asia-Pacific Society for Neurochemistry Kaohsiung, Taiwan. August 23-26, 2014]. 2014.

JIANG Q., SHI W., DE NOGUEIRA BOTELHO F.P., Ma C.W., Lai C.H., Shum D.K.Y. and Chan Y.S., Developmental modulation of long-term plasticity at vestibular GABAergic synapses, Journal of Neurochemistry , 130 Suppl 1: 65. 2014.

JIANG Q., Ma C.W., CHEN W., Shum D.K.Y. and Chan Y.S., Effects of fluoxetine on the restoration of plasticity in young adult vestibular nucleus, Abstracts of 10th Int’l Symp. on Healthy Aging: 80. 2015.

JIANG Q., Ma C.W., Chen C.W., Shum D.K.Y. and Chan Y.S., Effects of fluoxetine on the restoration of plasticity in young adult vestibular nucleus, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 80. 2015.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Regulatory role of perineuronal nets and semaphorin3A in the developmental maturation of the central vestibular circuitry, Abstracts of 9^th FENS Forum of Neuroscience, 2454. 2014.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., The involvement of perineuronal semaphorin 3A and chondroitin sulfates in regulating maturation of the central vestibular circuitry, Abstracts of 10th Int’l Symp. on Healthy Aging: 79. 2015.

Kwan P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., The involvement of perineuronal semaphoring 3A and chondroitin sulfates in regulating maturation of the central vestibular circuitry, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 79. 2015.

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilization of chondroitinase ABC-I and –II on chitosan microbeads improve neurite growth in CSPG-enriched astrocyte culture, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 64. 2015.

LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Chan Y.S., Cheung K.H. and Fung M.L., Lycium barbarum polysaccharides antagonized rat hippocampal-dependent spatial memory deficits induced by chronic intermittent hypoxia. The 8^th Pong Ding Yuen International Symposium on Traditional Chinese medicine cum The 2^nd International Chinese Symposium on Free Radical Research , The 6^th Symposium for Three Districts of Cross-straits on Free Radical Research, HK 11/2014.

LAM K.S.F., Ma C.W., DE NOGUEIRA BOTELHO F.P., Lai C.H., SHI W., Shum D.K.Y. and Chan Y.S., NKCC1 and KCC2 cotransporters are required in postnatal maturation of the vestibular system, Abstracts of 10th Int’l Symp. on Healthy Aging: 75. 2015.

LAM K.S.F., Ma C.W., DE NOGUEIRA BOTELHO F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., Neonatal perturbation of KCC2 and NKCC1 co-transporters in the developing vestibular nucleus impairs vestibular functions, Soc. Neuroscience Abstract (USA), 157.03/EE5. 2014.

LAU W.Y., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Characterization of Heparanase 1 and Heparanase 2 at Hippocampus, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

LAU W.Y., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Role of heparanase 1 and heparanase 2 in modulating synaptic activities, Abstracts of 10th Int’l Symp. on Healthy Aging: 77. 2015.

Lai C.H., Shiu S.Y. and Chan Y.S., Strengthening biomedical science education among non-medical students through a common core course, Asian Medical Education Association 2015 Conference [Newcastle, Australia. March 30 - April 1, 2015]. 2015.

Lam K.S., Ma C.W., DE NOGUEIRA BOTELHO F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., NKCC1 and KCC2 cotransporters are required in postnatal maturation of the vestibular system, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 75. 2015.

Lam W.Y., Cham W.C., Chan Y.S. and Shum D.K.Y., Role of heparanase 1 and heparanase 2 in modulating synaptic activities, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 77. 2015.

Lau W.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Expression of heparanase 1 and heparanase 2 at the hippocampus, Abstracts of 9^th FENS Forum of Neuroscience 777. [Milan, Italy. July 5-9, 2014]. 2014.

Ma C.W., Han L., Cham W.C., Chan Y.S. and Shum D.K.Y., Neuronal proheparanase regulates synaptic function of the central vestibular system., Abstracts of 9^th FENS Forum of Neuroscience 1603. 2014.

Shum D.K.Y., TAI W.Y.E., Shea G.H.K., Tsui Y.P., LEUNG H.Y. and Chan Y.S., Juxtacrine signalling via Notch and ErbB receptors in the switch to fate commitment of bone marrow-derived Schwann cells, Soc. Neuroscience Abstract (USA) 589.10/A21. 2014.

TAI W.Y.E., Shea G.K.H., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Guidance of DRG neurons in fate determination of bone marrow derived Schwann cells, 9th FENS Forum of Neuroscience. 2014.

TAI W.Y.E., Shea G.K., Leung K.H., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Instructive role of DRG neurons in derivation of Schwann cells from bone marrow stromal cells, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 57. 2015.

TUNG W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Nere guidance channel constructed by Schwann cell seeded aligned chitosan nanofiber, Journal of Neurochemistry, 130 Suppl 1: 49. 2014.

Tam K.W., Chan Y.S. and Shum D.K.Y., Stability and kinetics of chondroitinase ABC in macromolecular crowded environment, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 64. 2015.

Tsui Y.P., Shum D.K.Y. and Chan Y.S., Cell therapy for myelin disorder: derivation of two myelin-forming cell types from adult bone marrow stromal cells , Tenth International Symposium on Healthy Aging “A Decade of Positive Aging”. 2015.

Tsui Y.P., TAI W.Y.E., Shum D.K.Y. and Chan Y.S., Cell therapy for remyelination: Divergent routs for derivation of alternative glial cell fates from adult bone marrow stromal cells, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging : 56. 2015.

Tsui Y.P., Shum D.K.Y. and Chan Y.S., Divergent routes for derivation of alternative glial cell fate from adult bone marrow stromal cells for remyelination therapy, Gordon Research Conference - Molecular & Cellular Neurobiology. 2014.

Tsui Y.P., Shum D.K.Y. and Chan Y.S., Sun Chieh Yeh Young Investigator Award (Oral Category), Tenth International Symposium on Healthy Aging: A Decade of Positive Aging, Hong Kong, China. 2015.

Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Nerve conduit constructed by aligned chitosan nanofibers for directing axonal growth in nerve regeneration, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 64. 2015.

Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Nerve guidance channel constructed by Schwann cell seeded aligned chitosan nanofiber, Journal of Neurochemistry 130 Suppl 1: 49. 2014.

Wang H.T., Han Y.F., Chan Y.S. and He J., Stimulus-specific adaptation at the synapse level in vitro, PLoS One, 9: e114537. 2014.

Wong M.K., Li M., Chan Y.S. and Shum D.K.Y., Dynamics of chondroitin sulfotransferase expression for cranial motor neuron migration in rat hindbrain development, Abstracts of 9^th FENS Forum of Neuroscience, 2470. 2014.

Researcher : Chen J

Project Title:	Effects of Influenza A (H1N1) Virus Infection on Ion Transport of Pig Tracheal Epithelia
Investigator(s):	Chen J, Chen H, Li GR
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2013

Project Title:	CFTR Activation by Regional Phosphorylation on the R Domain
Investigator(s):	Chen J
Department:	Physiology
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	09/2013

Project Title:	Investigating the molecular mechanisms how ΔF508 mutation delays phosphorylation-dependent CFTR activation
Investigator(s):	Chen J
Department:	Physiology
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2014

Project Title:	Molecular mechanisms of bicarbonate transport and impaired pH sensitivity in ΔF508-CFTR
Investigator(s):	Chen J
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2015

Project Title:	The 5th International Ion Channel Conference (IICC-5): Structure, Function Regulation & Therapeutics; Deletions of the Y512 and F508 residues in the cystic fibrosis transmembrane conductance regulator may cause similar structural defects affecting protein processing
Investigator(s):	Chen J
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2015

List of Research Outputs

CHEN X., XU W., Li N.F. and Chen J., Basic defect in cystic fibrosis, In: Burkhard Tümmler, Mutation-specific therapies in cystic fibrosis - Current status and prospects. Bremen, UNI-MED Science, 2014, 1st edition: 21-23.

CHEN X. and Chen J., Deletions of the Y512 and F508 residues in the cystic fibrosis transmembrane conductance regulator may cause similar structural defects affecting protein processing, The 10th International Symposium on Healthy Aging, Hong Kong. 2015.

Chen J., A cocktail drug therapy for patients with cystic fibrosis?, J.Cyst.Fibros.. 2014, 13(5).

Li N.F., XU W. and Chen J., Pseudomonas aeruginosa altered the transepithelial conductance of pig tracheal epithelia, The 30th Joint Annual Conference of Biomedical Science/The Chinese Physiological Society, Taiwan. 2015.

Li N.F., XU W. and Chen J., Pseudomonas aeruginosa infection casued a time-dependent increase in transepithelial conductance of pig tracheal epithelia, The 10th International Symposium on Healthy Aging, Hong Kong. 2015.

XU W., Li N.F. and Chen J., Sodium ion in the apical solution is associated with the volume-regulated ion transport in pig tracheal epithelia, The 30th Joint Annual Conference of Biomedical Science, Taiwan. 2015.

XU W., Li N.F. and Chen J., Sodium ion in the apical solution is essential for a fluid-induced reduction in amiloride-sensitive transepithelial currents, The 10th International Symposium on Healthy Aging. 2015.

Xu W., Li N.F. and Chen J., Apical incubation of Krebs solution may alter Na+ transport in pig tracheal epithelia, The 19th Research Postgraduate Symposium. 2014.

ZHU S., XU W., Li N.F. and Chen J., Effects of transepithelial bicarbonate transport in bacterial killing on the surface of cultured pig tracheal epithelia, The 10th International Symposium on Healthy Aging, Hong Kong. 2015.

Researcher : Chen K

List of Research Outputs

Chen K., Liu H., Yang L., Jin M.W. and Li G.R., SKF-96365 strongly inhibits voltage-gated sodium current in rat ventricular myocytes, Pflügers Archiv - European Journal of Physiology. 2014.

Researcher : Cheung KH

Project Title:	Molecular Mechanism of Capacitative Calcium Entry Deficits in Presenilin Mutations and Its Role in Alzheimers Disease Pathogenesis
Investigator(s):	Cheung KH, Chan YS, Lee HC
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2011
Completion Date:	08/2014

Project Title:	Nuclear membrane electrophysiology of Ryanodine Receptor Channel
Investigator(s):	Cheung KH
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013
Completion Date:	04/2015

Project Title:	Nuclear Membrane Electrophysiology of Ryanodine Receptor And Its Regulation by cADPR
Investigator(s):	Cheung KH, Chen J
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2013

Project Title:	Role of intracellular calcium release channels in Asthma pathogenesis
Investigator(s):	Cheung KH, Leung GPH
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

Project Title:	Electrophysiological Characterization of the Two-Pore Channel 2
Investigator(s):	Cheung KH
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2014

Project Title:	Role of TMEM16A in the formation of epididymal microenvironment
Investigator(s):	Cheung KH
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2015

List of Research Outputs

CHEUNG C., Cheung K.H. and Leung G.P.H., Mechanisms of action of Xinmailong, a Chinese Medicine derived from Periplaneta Americana, in treating heart failure, 17th World Congress of Basic and Clinical Pharmacology 2014, Cape Town, South Africa from 13-18 July 2014.

Cheung K.H., Mechanism of Impaired Calcium Entry in Alzheimer’s Disease - Implications for Disease Pathogenesis, Diagnosis and Therapeutic Strategy, The 4th China Conference on Dementia and Cognitive Impairment. 2015.

LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Chan Y.S., Cheung K.H. and Fung M.L., Lycium barbarum polysaccharides antagonized rat hippocampal-dependent spatial memory deficits induced by chronic intermittent hypoxia. The 8^th Pong Ding Yuen International Symposium on Traditional Chinese medicine cum The 2^nd International Chinese Symposium on Free Radical Research , The 6^th Symposium for Three Districts of Cross-straits on Free Radical Research, HK 11/2014.

Lee S.K., Tong C.K., Cheng W.H. and Cheung K.H., Characterization of Two-Pore Channel 2 by Nuclear Membrane Electrophysiology, Gordon Research Conference in Calcium Signaling. 2015.

Lu Y., Dong S., Hao B., Li C., Zhu K., Guo W., Wang Q., Cheung K.H., Wong W.M. and Wu W., Vacuolin-1 potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A, Autophagy. 2014, 10: 1895-1905.

Researcher : Chow MZY

List of Research Outputs

CHEN G., LI S., Karakikes I., Ren L., Chow M.Z.Y., Chopra A., Keung W.W.Y., Yan B., Chan C.W.Y., Costa K.D., Kong M.C.W., Hajjar R.J., Chen C.S. and Li R.A., Phospholamban as a Crucial Determinant of the Inotropic Response of Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes and Engineered 3D Tissue Constructs, Circulation: Arrhythmia and Electrophysiology. 2014.

Weng J.Z., Kong M.C.W., Ren L., Karakikes I., Geng L., HE J., Chow M.Z.Y., Mok C.F., Keung W.W.Y., Chow C.H., Leung A.Y.H., Hajjar R.J., Li R.A. and Chan C.W.Y., A simple, cost-effective but highly efficient system for deriving ventricular cardiomyocytes from human pluripotent stem cells. PMID: 24564569 , Stem Cells & Development. 2014, 23(14): 1704-16.

Researcher : DE NOGUEIRA BOTELHO FP

List of Research Outputs

CHEN W., Ma C.W., DE NOGUEIRA BOTELHO F.P., HU H., LAM T.F., Lai C.H., Shum D.K.Y. and Chan Y.S., Early postnatal perturbation of inhibitory transmission in the vestibular nucleus governs the expression of spatial map and spatial navigation behaviors, Abstracts of 10th Int’l Symp. on Healthy Aging: 55. 2015.

CHEN W., Ma C.W., DE NOGUEIRA BOTELHO F.P., NG K.P., HU H., Bai Z.T., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of inhibitory transmission in the vestibular nucleus during an early postnatal stage impacts on the thalamic spatial map and spatial cognitive behaviors., Proc. 16^th Conference of Neuropsychopharamcology Wenzhou. September 25-28, 2014]. 2014.

Chen C.W., Ma C.W., DE NOGUEIRA BOTELHO F.P., HU H., Lam T.F., Lai C.H., Shum D.K.Y. and Chan Y.S., Early postnatal perturbation of inhibitory transmission the vestibular nucleus governs the expression of spatial map and spatial navigation behaviors, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 55. [HK. March 7-8, 2015]. 2015.

JIANG Q., SHI W., DE NOGUEIRA BOTELHO F.P., Ma C.W., Lai C.H., Shum D.K.Y. and Chan Y.S., Developmental modulation of long-term plasticity at vestibular GABAergic synapses, Journal of Neurochemistry , 130 Suppl 1: 65. 2014.

LAM K.S.F., Ma C.W., DE NOGUEIRA BOTELHO F.P., Lai C.H., SHI W., Shum D.K.Y. and Chan Y.S., NKCC1 and KCC2 cotransporters are required in postnatal maturation of the vestibular system, Abstracts of 10th Int’l Symp. on Healthy Aging: 75. 2015.

LAM K.S.F., Ma C.W., DE NOGUEIRA BOTELHO F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., Neonatal perturbation of KCC2 and NKCC1 co-transporters in the developing vestibular nucleus impairs vestibular functions, Soc. Neuroscience Abstract (USA), 157.03/EE5. 2014.

Lam K.S., Ma C.W., DE NOGUEIRA BOTELHO F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., NKCC1 and KCC2 cotransporters are required in postnatal maturation of the vestibular system, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 75. 2015.

Researcher : Fung ML

Project Title:	Neuroprotective effect of Lycium barbarum polysaccharides against hippocampal apoptosis induced by chronic intermittent hypoxia in rats
Investigator(s):	Fung ML
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2013

Project Title:	Protective effect of Lycium barbarum polysaccharides on spatial memory deficits induced by intermittent hypoxia in rats
Investigator(s):	Fung ML
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

Project Title:	19th International meeting of ISAC The International Society for Arterial Chemoreception; Nitric oxide deficit is part of the maladaptive paracrine-autocrine response of the carotid body to intermittent hypoxia in sleep apnea
Investigator(s):	Fung ML
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2014
Completion Date:	07/2014

Project Title:	Pathophysiological role of nitric oxide deficit in the carotid body function in intermittent hypoxia
Investigator(s):	Fung ML
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2015

List of Research Outputs

Fung M.L., Effects of antioxidant and Chinese medicine against pathophysiological consequences of sleep apnea. The 8^th Pong Ding Yuen International Symposium on Traditional Chinese medicine cum The 2^nd International Chinese Symposium on Free Radical Research, The 6^th Symposium for Three Districts of Cross-straits on Free Radical Research, HK 11/. 2014.

Fung M.L., Expressions of angiotensin and cytokine receptors in the paracrine signaling of the carotid body in hypoxia and sleep apnea, Respiratory Physiology & Neurobiology . 2015, 209: 6-12.

Fung M.L., Nitric oxide deficit is part of the maladaptive paracrine-autocrine response of the carotid body to intermittent hypoxia in sleep apnea, The 19^th International Society for Arterial Chemoreception Meeting, Leeds, UK, L30, 7/2014.

Fung M.L., Pathogenic roles of the carotid body inflammation in sleep apnea, Mediators of Inflammation: Inflammation in Sleep Debt and Sleep Disorders, Edited by Leila Kheirandish-Gozal, David Gozal, Jean Louis Pepin. Hindawi, New York 354279. 2014.

Fung M.L., The role of local renin-angiotensin system in arterial chemoreceptors in sleep-breathing disorders, Frontiers in Integrative Physiology: Carotid body: a new target for rescuing neural control of cardiorespiratory balance in disease, Edited by Rodrigo Iturriaga, Rodrigo Del Rio, Harold D Schultz. Switzerland fphys 00336. 2014, 5:336.

Guo R., Liong E.C., So K.F., Fung M.L. and Tipoe G.L., Beneficial mechanisms of aerobic exercise on hepatic lipid metabolism in non-alcoholic fatty liver disease, Hepatobiliary Pancreatic Diseases International. 2015, 14: 139-144.

LAM C.S., Liu Y.Y., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia induces depressive-like behavior in rats. The 18^th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, Journal of the Hong Kong College of Cardiology CP8. 2014, 22(2): 55.

LAM C.S., LIU Y.Y., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia provokes depressive-like responses in rats, 19^th Research Postgraduate Symposium, HKU, P4.01,. 2014.

LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Chan Y.S., Cheung K.H. and Fung M.L., Lycium barbarum polysaccharides antagonized rat hippocampal-dependent spatial memory deficits induced by chronic intermittent hypoxia. The 8^th Pong Ding Yuen International Symposium on Traditional Chinese medicine cum The 2^nd International Chinese Symposium on Free Radical Research , The 6^th Symposium for Three Districts of Cross-straits on Free Radical Research, HK 11/2014.

LAM C.S., LI J.J., Tipoe G.L. and Fung M.L., Mechanistic roles of monoamine oxidase-A in the induction of depressive-like behavior by chronic intermittent hypoxia in rats, The Tenth International Symposium on Healthy Aging – A Decade of Positive Aging, OP7 3/2015.

LI J.J., LAM C.S., Tipoe G.L. and Fung M.L., Intermittent hypoxia increases the expression of monoamine oxidase-A in SH-SY5Y cells, The Tenth International Symposium on Healthy Aging – A Decade of Positive Aging, P40 3/2015.

Lam C.S., Tipoe G.L., So K.F. and Fung M.L., Neuroprotective Mechanism of Lycium barbarum Polysaccharides against Hippocampal-Dependent Spatial Memory Deficits in a Rat Model of Obstructive Sleep Apnea, PLOS ONE. 2015, 10: e0117990.

Liu Y., Tipoe G.L. and Fung M.L., Melatonin Attenuates Intermittent Hypoxia-Induced Lipid Peroxidation and Local Inflammation in Rat Adrenal Medulla, International Journal of Molecular Sciences. 2014, 15 (10): 18437-18452.

Pan J., Guo R., Liong E.C., Tipoe G.L. and Fung M.L., Apocynin attenuates the oxidative stress and inflammation induced by palmitate and intermittent hypoxia in HepG2 cells. The 8^th Pong Ding Yuen International Symposium on Traditional Chinese medicine cum The 2^nd International Chinese Symposium on Free Radical Research , The 6^th Symposium for Three Districts of Cross-straits on Free Radical Research, HK 11/2014.

Pan J., Guo R., Liong E.C., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia aggravates oxidative stress, inflammation and apoptosis in non-alcoholic fatty liver disease, 19^th Research Postgraduate Symposium, HKU P7.01. 2014.

Pan J., Guo R., Liong E.C., Tipoe G.L. and Fung M.L., Intermittent hypoxia aggravates early pathogenesis of non-alcoholic fatty liver disease in rats. The 18^thAnnual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, Journal of the Hong Kong College of Cardiology CP6. 2014, 22(2): 54.

Pan J., Guo R., Liong E.C., Tipoe G.L. and Fung M.L., Intermittent hypoxia-induced oxidative stress aggravates inflammation induced by palmitate via Toll-like receptor 4 in a cell model of non-alcoholic fatty liver disease, The 1^st European Fatty Liver Conference, Masstricht (the Netherlands) 3/2015.

Pan J., Guo R., Tipoe G.L. and Fung M.L., NADPH oxidase induced by intermittent hypoxia exacerbates oxidative stress, inflammation and apoptosis in a cell model of non-alcoholic fatty liver disease, The Liver Meeting 2014 American Association for the Study of Liver Diseases, Boston, USA. 2014.

Xiao J., Liong E.C., Huang H., Tse W.O., Lau K.S., Pan J., Nanji A.A., Fung M.L., Xing F. and Tipoe G.L., Cycloxygenase-1 serves a vital hepato-protective function in chemically induced acute liver injury, Toxicological Sciences. 2015, 143(2): 430-440.

Xiao J., Xing F., Huo J., Fung M.L., Liong E.C., Ching Y.P., Xu A., Chang R.C.C., So K.F. and Tipoe G.L., Lycium barbarum polysaccharides therapeutically improve hepatic functions in non-alcoholic steatohepatitis rats and cellular steatosis model, Scientific Reports. 2014, 4: 5587.

Yeung H.M., Hung M.W., Lau C.F. and Fung M.L., Cardioprotective effects of melatonin against myocardial injuries induced by chronic intermittent hypoxia in rats, Journal of Pineal Research. 2014, 58(1): 12-25.

Researcher : Geng L

List of Research Outputs

Weng J.Z., Kong M.C.W., Ren L., Karakikes I., Geng L., HE J., Chow M.Z.Y., Mok C.F., Keung W.W.Y., Chow C.H., Leung A.Y.H., Hajjar R.J., Li R.A. and Chan C.W.Y., A simple, cost-effective but highly efficient system for deriving ventricular cardiomyocytes from human pluripotent stem cells. PMID: 24564569 , Stem Cells & Development. 2014, 23(14): 1704-16.

Researcher : Graeff RM

List of Research Outputs

Swarbrick J.M., Graeff R.M., Zhang H., Thomas M.P., Hao Q. and Potter B.V.L., Cyclic Adenosine 5′-Diphosphate Ribose Analogs without a “Southern” Ribose Inhibit ADP-ribosyl Cyclase–Hydrolase CD38, Journal of Medicinal Chemistry. 2014, 57: 8517-8529.

Researcher : HU H

List of Research Outputs

CHEN W., Ma C.W., DE NOGUEIRA BOTELHO F.P., HU H., LAM T.F., Lai C.H., Shum D.K.Y. and Chan Y.S., Early postnatal perturbation of inhibitory transmission in the vestibular nucleus governs the expression of spatial map and spatial navigation behaviors, Abstracts of 10th Int’l Symp. on Healthy Aging: 55. 2015.

CHEN W., Ma C.W., DE NOGUEIRA BOTELHO F.P., NG K.P., HU H., Bai Z.T., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of inhibitory transmission in the vestibular nucleus during an early postnatal stage impacts on the thalamic spatial map and spatial cognitive behaviors., Proc. 16^th Conference of Neuropsychopharamcology Wenzhou. September 25-28, 2014]. 2014.

Chen C.W., Ma C.W., DE NOGUEIRA BOTELHO F.P., HU H., Lam T.F., Lai C.H., Shum D.K.Y. and Chan Y.S., Early postnatal perturbation of inhibitory transmission the vestibular nucleus governs the expression of spatial map and spatial navigation behaviors, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 55. [HK. March 7-8, 2015]. 2015.

Researcher : Han L

Project Title:	the 44th annual meeting of society for neuroscience, U.S.A; Functional identification of GABAergic medial vestibular neurons in VGAT-Venus transgenic mice
Investigator(s):	Han L
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2014
Completion Date:	11/2014

Project Title:	Postsynaptic plasticity: Differential roles of inhibitory and excitatory vestibular nuclear neurons
Investigator(s):	Han L, Chan YS
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2015

List of Research Outputs

Chan Y.S., Ma C.W., Ng K.P., Han L. and Shum D.K.Y., Glutamatergic transmission in the vestibular nucleus is critical to the formation of spatial topography and acquisition of spatial navigation in rats behaviour, Society Neuroscience Abstract (USA), 157.01/EE3. 2014.

Chan Y.S., Ma C.W., Ng K.P., Han L. and Shum D.K.Y., Glutamatergic transmission in the vestibular nucleus is critical to the formation of spatial topography and acquisition of spatial navigation in rats, Soc. Neuroscience Abstract (USA) 157.01/EE3 [Washington DC. Nov. 15-19, 2014]. 2014.

Han L., Yanagawa Y. and Chan Y.S., Functional identification of GABAergic medial vestibular neurons in VGAT-Venus transgenic mice, Soc. Neuroscience Abstract (USA) 157.02/EE4. 2014.

Han L., Yanagawa Y. and Chan Y.S., Intrinsic membrane properties of neurons in medial vestibular nucleus of VGAT-Venus transgenic mice, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 75. 2015.

Han L., Lai S.K., Lai C.H. and Chan Y.S., Serotoninergic control of synaptic transmission in rat medial vestibular nucleus, Journal of Neurochemistry , 130 Suppl 1 : 28. [11^th Biennial Meeting of Asia-Pacific Society for Neurochemistry Kaohsiung, Taiwan. August 23-26, 2014]. 2014.

Ma C.W., Han L., Cham W.C., Chan Y.S. and Shum D.K.Y., Neuronal proheparanase regulates synaptic function of the central vestibular system., Abstracts of 9^th FENS Forum of Neuroscience 1603. 2014.

Researcher : Hao Q

Project Title:	Engineering CD38 for Calcium Signaling
Investigator(s):	Hao Q
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2011
Completion Date:	09/2014

Project Title:	Structure and Function of the TRPM2 channel
Investigator(s):	Hao Q, Kotaka M, Lee HC
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012

Project Title:	Structural Biology of Human PECAM-1 (CD31) in Cell Adhesion and Leukocyte Transmigration
Investigator(s):	Hao Q, Zhang H
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2012

Project Title:	Investigation of pathogenesis mechanism of two infectious fungi Penicillium marneffei and Aspergillus fumigatus
Investigator(s):	Hao Q
Department:	Physiology
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2014

Project Title:	Asia Oceania Forum for Synchrotron Radiation Research; Novel Structure and function of human sirtuins
Investigator(s):	Hao Q
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2014
Completion Date:	09/2014

Project Title:	Novel Structure and Function of Human Sirtuins
Investigator(s):	Hao Q, Huang J, Li X
Department:	Physiology
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	03/2015

Project Title:	Structure and Function of Human SIRT4
Investigator(s):	Hao Q
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2015

List of Research Outputs

BAO X., Wang Y., LI X., LI X., LIU Z., YANG T., Wong C.F., Zhang J., Hao Q. and Li X., Identification of ‘erasers’ for lysine crotonylated histone marks using a chemical proteomics approach, eLife. 2014, 3.

Hao Q., Novel Structure and Function of Human Sirtuins, 8th Asia Oceania Forum for Synchrotron Radiation Research (AOFSRR 2014). 2014.

Hao Q., Powder to become crystal clear, IUCrJ. 2015, 2: 307-308.

Swarbrick J.M., Graeff R.M., Zhang H., Thomas M.P., Hao Q. and Potter B.V.L., Cyclic Adenosine 5′-Diphosphate Ribose Analogs without a “Southern” Ribose Inhibit ADP-ribosyl Cyclase–Hydrolase CD38, Journal of Medicinal Chemistry. 2014, 57: 8517-8529.

Teng Y.B., Jing H., . Aramsangtienchai P., He B., Khan S., Hu J., Lin H. and Hao Q., Efficient Demyristoylase Activity of SIRT2 Revealed by Kinetic and Structural Studies, Scientific Reports. 2015, 5: 8529.

ZHANG W., Zhang T., Zhang H. and Hao Q., Crystallographic phasing with NMR models: an envelope approach, Acta Crystallographica Section D Biological Crystallography. 2014, 70: 1977-1982.

Researcher : JIANG Q

List of Research Outputs

JIANG Q., Ma C.W., CHEN W., Shum D.K.Y. and Chan Y.S., Effects of fluoxetine on the restoration of plasticity in young adult vestibular nucleus, Abstracts of 10th Int’l Symp. on Healthy Aging: 80. 2015.

JIANG Q., Ma C.W., Chen C.W., Shum D.K.Y. and Chan Y.S., Effects of fluoxetine on the restoration of plasticity in young adult vestibular nucleus, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 80. 2015.

Researcher : Keung WWY

Project Title:	Driving maturation of human embryonic stem cell-derived cardiomyocytes through metabolic conditioning in 2D and 3D environment
Investigator(s):	Keung WWY
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	09/2014

Project Title:	International Society for Stem Cell Research 2015 Annual Meeting; Engineering a high-biofidelity, mechanically and electrophysiologically functional 3D human ventricular pump from pluripotent stem cells: A human cell-based bioartificial heart prototype
Investigator(s):	Keung WWY
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2015

List of Research Outputs

CHEN G., LI S., Karakikes I., Ren L., Chow M.Z.Y., Chopra A., Keung W.W.Y., Yan B., Chan C.W.Y., Costa K.D., Kong M.C.W., Hajjar R.J., Chen C.S. and Li R.A., Phospholamban as a Crucial Determinant of the Inotropic Response of Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes and Engineered 3D Tissue Constructs, Circulation: Arrhythmia and Electrophysiology. 2014.

Fillmore N., Keung W.W.Y., Kelly S.E., Proctor S.P., Lopaschuk G.D. and Ussher J.R., Accumulation of ceramide in slow-twitch muscle contributes to the development of insulin resistance in the obese JCR:LA-cp rat, Experimental Physiology. 2015, 100: 730-741.

Lam V.H., Zhang L., Huqi A., Fukushima A., Tanner B.A., Onay-Basikci A., Keung W.W.Y., Kantor P.F., Jaswal J.S. and Rebeyka I.M., Activating PPAR Prevents Post-Ischemic Contractile Dysfunction in Hypertrophied Neonatal Hearts, Circulation Research. 2015, 117: 41-51.

Ussher J.R., Fillmore N., Keung W.W.Y., Mori J., Beker D.L., Wagg C.S., Jaswal J.S. and Lopaschuk G.D., Trimetazidine Therapy Prevents Obesity-Induced Cardiomyopathy in Mice, Canadian Journal of Cardiology. 2014, 30: 940-944.

Weng J.Z., Kong M.C.W., Ren L., Karakikes I., Geng L., HE J., Chow M.Z.Y., Mok C.F., Keung W.W.Y., Chow C.H., Leung A.Y.H., Hajjar R.J., Li R.A. and Chan C.W.Y., A simple, cost-effective but highly efficient system for deriving ventricular cardiomyocytes from human pluripotent stem cells. PMID: 24564569 , Stem Cells & Development. 2014, 23(14): 1704-16.

Researcher : Kong MCW

List of Research Outputs

CHEN G., LI S., Karakikes I., Ren L., Chow M.Z.Y., Chopra A., Keung W.W.Y., Yan B., Chan C.W.Y., Costa K.D., Kong M.C.W., Hajjar R.J., Chen C.S. and Li R.A., Phospholamban as a Crucial Determinant of the Inotropic Response of Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes and Engineered 3D Tissue Constructs, Circulation: Arrhythmia and Electrophysiology. 2014.

Karakikes I., Stillitano F., Nonnenmacher M., Tzimas C., Sanoudou D., Termglinchan V., Kong M.C.W., Rushing S., Hansen J., Ceholski D., Kolokathis F., Kremastinos D., Katoulis A., Ren L., Cohen N., Gho J.M.I.H., Tsiapras D., Vink A., Wu J.C., Asselbergs F.W., Li R.A., Hulot J.S., Kranias E.G. and Hajjar R.J., Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy, Nature Communications. 2015, 6: 6955.

Researcher : Kotaka M

List of Research Outputs

Waye M.M.Y., Baum L., Boyde T.R.C., Chan K.K.K., Cherny S.S., Choy F., Garcia-Barcelo M.M., Gong Z., Kagawa H., Kotaka M., Lee C.Y., Lee S.M.Y., Li H.Y., Meng H., Ng R.K., Ng T.B., Pollard J., Qi R., Shen D.W., Tam S.S.W., Tsang F.S.Y., Wasylyk B., Xue H. and Siu C.O., Genetics and Epigenetics of Bipolar Disorder, Journal of Biochemistry and Molecular Biology in the Post Genomic Era. 2014, 2 (2).

Researcher : LAM CS

List of Research Outputs

LAM C.S., Liu Y.Y., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia induces depressive-like behavior in rats. The 18^th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, Journal of the Hong Kong College of Cardiology CP8. 2014, 22(2): 55.

LAM C.S., LIU Y.Y., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia provokes depressive-like responses in rats, 19^th Research Postgraduate Symposium, HKU, P4.01,. 2014.

LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Chan Y.S., Cheung K.H. and Fung M.L., Lycium barbarum polysaccharides antagonized rat hippocampal-dependent spatial memory deficits induced by chronic intermittent hypoxia. The 8^th Pong Ding Yuen International Symposium on Traditional Chinese medicine cum The 2^nd International Chinese Symposium on Free Radical Research , The 6^th Symposium for Three Districts of Cross-straits on Free Radical Research, HK 11/2014.

LAM C.S., LI J.J., Tipoe G.L. and Fung M.L., Mechanistic roles of monoamine oxidase-A in the induction of depressive-like behavior by chronic intermittent hypoxia in rats, The Tenth International Symposium on Healthy Aging – A Decade of Positive Aging, OP7 3/2015.

LI J.J., LAM C.S., Tipoe G.L. and Fung M.L., Intermittent hypoxia increases the expression of monoamine oxidase-A in SH-SY5Y cells, The Tenth International Symposium on Healthy Aging – A Decade of Positive Aging, P40 3/2015.

Lam C.S., Tipoe G.L., So K.F. and Fung M.L., Neuroprotective Mechanism of Lycium barbarum Polysaccharides against Hippocampal-Dependent Spatial Memory Deficits in a Rat Model of Obstructive Sleep Apnea, PLOS ONE. 2015, 10: e0117990.

Researcher : LAM KSF

List of Research Outputs

LAM K.S.F., Ma C.W., DE NOGUEIRA BOTELHO F.P., Lai C.H., SHI W., Shum D.K.Y. and Chan Y.S., NKCC1 and KCC2 cotransporters are required in postnatal maturation of the vestibular system, Abstracts of 10th Int’l Symp. on Healthy Aging: 75. 2015.

LAM K.S.F., Ma C.W., DE NOGUEIRA BOTELHO F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., Neonatal perturbation of KCC2 and NKCC1 co-transporters in the developing vestibular nucleus impairs vestibular functions, Soc. Neuroscience Abstract (USA), 157.03/EE5. 2014.

Researcher : LAM TF

List of Research Outputs

CHEN W., Ma C.W., DE NOGUEIRA BOTELHO F.P., HU H., LAM T.F., Lai C.H., Shum D.K.Y. and Chan Y.S., Early postnatal perturbation of inhibitory transmission in the vestibular nucleus governs the expression of spatial map and spatial navigation behaviors, Abstracts of 10th Int’l Symp. on Healthy Aging: 55. 2015.

Researcher : LI S

List of Research Outputs

CHEN G., LI S., Karakikes I., Ren L., Chow M.Z.Y., Chopra A., Keung W.W.Y., Yan B., Chan C.W.Y., Costa K.D., Kong M.C.W., Hajjar R.J., Chen C.S. and Li R.A., Phospholamban as a Crucial Determinant of the Inotropic Response of Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes and Engineered 3D Tissue Constructs, Circulation: Arrhythmia and Electrophysiology. 2014.

Researcher : Lai CH

List of Research Outputs

CHEN W., Ma C.W., DE NOGUEIRA BOTELHO F.P., HU H., LAM T.F., Lai C.H., Shum D.K.Y. and Chan Y.S., Early postnatal perturbation of inhibitory transmission in the vestibular nucleus governs the expression of spatial map and spatial navigation behaviors, Abstracts of 10th Int’l Symp. on Healthy Aging: 55. 2015.

CHEN W., Ma C.W., DE NOGUEIRA BOTELHO F.P., NG K.P., HU H., Bai Z.T., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of inhibitory transmission in the vestibular nucleus during an early postnatal stage impacts on the thalamic spatial map and spatial cognitive behaviors., Proc. 16^th Conference of Neuropsychopharamcology Wenzhou. September 25-28, 2014]. 2014.

Chen C.W., Ma C.W., DE NOGUEIRA BOTELHO F.P., HU H., Lam T.F., Lai C.H., Shum D.K.Y. and Chan Y.S., Early postnatal perturbation of inhibitory transmission the vestibular nucleus governs the expression of spatial map and spatial navigation behaviors, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 55. [HK. March 7-8, 2015]. 2015.

Han L., Lai S.K., Lai C.H. and Chan Y.S., Serotoninergic control of synaptic transmission in rat medial vestibular nucleus, Journal of Neurochemistry , 130 Suppl 1 : 28. [11^th Biennial Meeting of Asia-Pacific Society for Neurochemistry Kaohsiung, Taiwan. August 23-26, 2014]. 2014.

JIANG Q., SHI W., DE NOGUEIRA BOTELHO F.P., Ma C.W., Lai C.H., Shum D.K.Y. and Chan Y.S., Developmental modulation of long-term plasticity at vestibular GABAergic synapses, Journal of Neurochemistry , 130 Suppl 1: 65. 2014.

LAM K.S.F., Ma C.W., DE NOGUEIRA BOTELHO F.P., Lai C.H., SHI W., Shum D.K.Y. and Chan Y.S., NKCC1 and KCC2 cotransporters are required in postnatal maturation of the vestibular system, Abstracts of 10th Int’l Symp. on Healthy Aging: 75. 2015.

LAM K.S.F., Ma C.W., DE NOGUEIRA BOTELHO F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., Neonatal perturbation of KCC2 and NKCC1 co-transporters in the developing vestibular nucleus impairs vestibular functions, Soc. Neuroscience Abstract (USA), 157.03/EE5. 2014.

Lai C.H., Shiu S.Y. and Chan Y.S., Strengthening biomedical science education among non-medical students through a common core course, Asian Medical Education Association 2015 Conference [Newcastle, Australia. March 30 - April 1, 2015]. 2015.

Lam K.S., Ma C.W., DE NOGUEIRA BOTELHO F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., NKCC1 and KCC2 cotransporters are required in postnatal maturation of the vestibular system, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 75. 2015.

Researcher : Lai KO

Project Title:	Investigating arginine methylation of synaptic proteins and its potential function in dendritic spine development
Investigator(s):	Lai KO
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	07/2014

Project Title:	Scientific Conferences for the Chinese Association for Physiological Sciences; Cdk5-mediated phosphorylation is required for the development and plasticity of dendritic spines
Investigator(s):	Lai KO
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2014
Completion Date:	10/2014

Project Title:	Investigating the functional role of a novel synaptic protein TBC1D24 in activity-dependent spine morphogenesis.
Investigator(s):	Lai KO
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2014

List of Research Outputs

Lai K.O., Fei E., Liang Z., Huang H. and Ip N.Y., Phosphorylation of p70 ribosomal S6 Kinase (S6K1) by Cdk5 is required for dendritic spine maturation, Gordon Research Conference (Molecular & Cellular Neurobiology) 2014.

Researcher : Lai SK

List of Research Outputs

Han L., Lai S.K., Lai C.H. and Chan Y.S., Serotoninergic control of synaptic transmission in rat medial vestibular nucleus, Journal of Neurochemistry , 130 Suppl 1 : 28. [11^th Biennial Meeting of Asia-Pacific Society for Neurochemistry Kaohsiung, Taiwan. August 23-26, 2014]. 2014.

Researcher : Lai SWC

Project Title:	The role of sleep on fear learning and experience-dependent dendritic spine plasticity
Investigator(s):	Lai SWC
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	07/2014

Project Title:	中国生理学会第24届全国生理学学术大会; Opposing dendritic spine plasticity of fear learning and unlearning in neocortex
Investigator(s):	Lai SWC
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2014
Completion Date:	10/2014

List of Research Outputs

Lai S.W.C., Fear conditioning and extinction induce opposing dendritic spine plasticity in neocortex, The 12th Meeting of the Asian-Pacific Society for Neurochemistry. 2014, 130: 4-25.

Lai S.W.C., Intravital imaging of dendritic spine plasticity, IntraVital. 2015, 1-6.

Researcher : Lam CS

List of Research Outputs

LAM C.S., LIU Y.Y., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia provokes depressive-like responses in rats, 19^th Research Postgraduate Symposium, HKU, P4.01,. 2014.

Researcher : Lee HC

Project Title:	Regulation of the Calcium Messenger Cyclic ADP-ribose.
Investigator(s):	Lee HC
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2011

Researcher : Leung CFP

Project Title:	Regulation of CD38 in abscisic acid-activated human monocytes.
Investigator(s):	Leung CFP, Lee HC
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	09/2009

Researcher : Li NF

List of Research Outputs

CHEN X., XU W., Li N.F. and Chen J., Basic defect in cystic fibrosis, In: Burkhard Tümmler, Mutation-specific therapies in cystic fibrosis - Current status and prospects. Bremen, UNI-MED Science, 2014, 1st edition: 21-23.

Li N.F., XU W. and Chen J., Pseudomonas aeruginosa altered the transepithelial conductance of pig tracheal epithelia, The 30th Joint Annual Conference of Biomedical Science/The Chinese Physiological Society, Taiwan. 2015.

Li N.F., XU W. and Chen J., Pseudomonas aeruginosa infection casued a time-dependent increase in transepithelial conductance of pig tracheal epithelia, The 10th International Symposium on Healthy Aging, Hong Kong. 2015.

XU W., Li N.F. and Chen J., Sodium ion in the apical solution is associated with the volume-regulated ion transport in pig tracheal epithelia, The 30th Joint Annual Conference of Biomedical Science, Taiwan. 2015.

XU W., Li N.F. and Chen J., Sodium ion in the apical solution is essential for a fluid-induced reduction in amiloride-sensitive transepithelial currents, The 10th International Symposium on Healthy Aging. 2015.

Xu W., Li N.F. and Chen J., Apical incubation of Krebs solution may alter Na+ transport in pig tracheal epithelia, The 19th Research Postgraduate Symposium. 2014.

ZHU S., XU W., Li N.F. and Chen J., Effects of transepithelial bicarbonate transport in bacterial killing on the surface of cultured pig tracheal epithelia, The 10th International Symposium on Healthy Aging, Hong Kong. 2015.

Researcher : Li RA

Project Title:	Cell-based Heart Regeneration
Investigator(s):	Li RA, Boheler KR, Chan BP, Chan CWY, Chan GCF, Chien KR, Lee HC, Yue J, Ng RK, Ngan AHW
Department:	Medicine
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	09/2011

Project Title:	Human WT1 epicardial progenitor cells
Investigator(s):	Li RA
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	Stem Cell and Regenerative Medicine
Investigator(s):	Li RA, Chan GCF, Tse HF
Department:	Physiology
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	06/2013

Project Title:	Engineering Calcium Homeostasis of hESC-derived cardiomyocytes
Investigator(s):	Li RA
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2013

Project Title:	Ontogenic combinatorial conditioning of 3D human pluripotent stem cell ventricular models for facilitated maturation
Investigator(s):	Li RA
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2014

Project Title:	International Society for Stem Cell Research 2015 Annual meeting; IMMUNOSUPPRESSIVE EFFECTS OF HUMAN PLURIPOTENT STEM CELL – DERIVED VENTRICULAR CARDIOMYOCYTES TOWARD HUMAN DENDRITIC CELLS
Investigator(s):	Li RA
Department:	LKS Medical Faculty
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2015

List of Research Outputs

Karakikes I., Stillitano F., Nonnenmacher M., Tzimas C., Sanoudou D., Termglinchan V., Kong M.C.W., Rushing S., Hansen J., Ceholski D., Kolokathis F., Kremastinos D., Katoulis A., Ren L., Cohen N., Gho J.M.I.H., Tsiapras D., Vink A., Wu J.C., Asselbergs F.W., Li R.A., Hulot J.S., Kranias E.G. and Hajjar R.J., Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy, Nature Communications. 2015, 6: 6955.

Researcher : Liu H

List of Research Outputs

Chen K., Liu H., Yang L., Jin M.W. and Li G.R., SKF-96365 strongly inhibits voltage-gated sodium current in rat ventricular myocytes, Pflügers Archiv - European Journal of Physiology. 2014.

Yang L., Liu H., Sun H. and Li G.R., Intravenous Anesthetic Propofol Inhibits Multiple Human Cardiac Potassium Channels, Anesthesiology. 2014, 122(3): 571-84.

Researcher : Lung MAKY

Project Title:	Endothelins in nasal mucosa: role in nasal congestion and decongestion
Investigator(s):	Lung MAKY
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

List of Research Outputs

Botelho M.G., Lam O.L.T., Watt R.M., Yip V.S.P., Shum D.K.Y. and Lung M.A.K.Y., Peer generated MCQs to assess and support for learning in a Problem Based Learning Programme, International Conference: Assessment for Learning in Higher Education 2015. .

Researcher : Lung MKY

Project Title:	Endothelins in nasal mucosa: role in nasal congestion and decongestion
Investigator(s):	Lung MAKY
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

List of Research Outputs

Researcher : Ma CW

Project Title:	Excitation-inhibition balance in central vestibular circuitry is critical to spatial recognition
Investigator(s):	Ma CW, Chan YS
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2014

Project Title:	The 9th FENS Forum of Neuroscience; Neuronal proheparanase regulates synaptic function of the central vestibular system
Investigator(s):	Ma CW
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2014
Completion Date:	07/2014

List of Research Outputs

CHEN W., Ma C.W., DE NOGUEIRA BOTELHO F.P., HU H., LAM T.F., Lai C.H., Shum D.K.Y. and Chan Y.S., Early postnatal perturbation of inhibitory transmission in the vestibular nucleus governs the expression of spatial map and spatial navigation behaviors, Abstracts of 10th Int’l Symp. on Healthy Aging: 55. 2015.

CHEN W., Ma C.W., DE NOGUEIRA BOTELHO F.P., NG K.P., HU H., Bai Z.T., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of inhibitory transmission in the vestibular nucleus during an early postnatal stage impacts on the thalamic spatial map and spatial cognitive behaviors., Proc. 16^th Conference of Neuropsychopharamcology Wenzhou. September 25-28, 2014]. 2014.

Chan Y.S., Ma C.W., Ng K.P., Han L. and Shum D.K.Y., Glutamatergic transmission in the vestibular nucleus is critical to the formation of spatial topography and acquisition of spatial navigation in rats behaviour, Society Neuroscience Abstract (USA), 157.01/EE3. 2014.

Chan Y.S., Ma C.W., Ng K.P., Han L. and Shum D.K.Y., Glutamatergic transmission in the vestibular nucleus is critical to the formation of spatial topography and acquisition of spatial navigation in rats, Soc. Neuroscience Abstract (USA) 157.01/EE3 [Washington DC. Nov. 15-19, 2014]. 2014.

Chen C.W., Ma C.W., DE NOGUEIRA BOTELHO F.P., HU H., Lam T.F., Lai C.H., Shum D.K.Y. and Chan Y.S., Early postnatal perturbation of inhibitory transmission the vestibular nucleus governs the expression of spatial map and spatial navigation behaviors, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 55. [HK. March 7-8, 2015]. 2015.

JIANG Q., SHI W., DE NOGUEIRA BOTELHO F.P., Ma C.W., Lai C.H., Shum D.K.Y. and Chan Y.S., Developmental modulation of long-term plasticity at vestibular GABAergic synapses, Journal of Neurochemistry , 130 Suppl 1: 65. 2014.

JIANG Q., Ma C.W., CHEN W., Shum D.K.Y. and Chan Y.S., Effects of fluoxetine on the restoration of plasticity in young adult vestibular nucleus, Abstracts of 10th Int’l Symp. on Healthy Aging: 80. 2015.

JIANG Q., Ma C.W., Chen C.W., Shum D.K.Y. and Chan Y.S., Effects of fluoxetine on the restoration of plasticity in young adult vestibular nucleus, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 80. 2015.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Regulatory role of perineuronal nets and semaphorin3A in the developmental maturation of the central vestibular circuitry, Abstracts of 9^th FENS Forum of Neuroscience, 2454. 2014.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., The involvement of perineuronal semaphorin 3A and chondroitin sulfates in regulating maturation of the central vestibular circuitry, Abstracts of 10th Int’l Symp. on Healthy Aging: 79. 2015.

Kwan P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., The involvement of perineuronal semaphoring 3A and chondroitin sulfates in regulating maturation of the central vestibular circuitry, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 79. 2015.

LAM K.S.F., Ma C.W., DE NOGUEIRA BOTELHO F.P., Lai C.H., SHI W., Shum D.K.Y. and Chan Y.S., NKCC1 and KCC2 cotransporters are required in postnatal maturation of the vestibular system, Abstracts of 10th Int’l Symp. on Healthy Aging: 75. 2015.

LAM K.S.F., Ma C.W., DE NOGUEIRA BOTELHO F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., Neonatal perturbation of KCC2 and NKCC1 co-transporters in the developing vestibular nucleus impairs vestibular functions, Soc. Neuroscience Abstract (USA), 157.03/EE5. 2014.

LAU W.Y., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Characterization of Heparanase 1 and Heparanase 2 at Hippocampus, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

LAU W.Y., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Role of heparanase 1 and heparanase 2 in modulating synaptic activities, Abstracts of 10th Int’l Symp. on Healthy Aging: 77. 2015.

Lam K.S., Ma C.W., DE NOGUEIRA BOTELHO F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., NKCC1 and KCC2 cotransporters are required in postnatal maturation of the vestibular system, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 75. 2015.

Lau W.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Expression of heparanase 1 and heparanase 2 at the hippocampus, Abstracts of 9^th FENS Forum of Neuroscience 777. [Milan, Italy. July 5-9, 2014]. 2014.

Ma C.W., Han L., Cham W.C., Chan Y.S. and Shum D.K.Y., Neuronal proheparanase regulates synaptic function of the central vestibular system., Abstracts of 9^th FENS Forum of Neuroscience 1603. 2014.

Researcher : Mok CF

List of Research Outputs

Weng J.Z., Kong M.C.W., Ren L., Karakikes I., Geng L., HE J., Chow M.Z.Y., Mok C.F., Keung W.W.Y., Chow C.H., Leung A.Y.H., Hajjar R.J., Li R.A. and Chan C.W.Y., A simple, cost-effective but highly efficient system for deriving ventricular cardiomyocytes from human pluripotent stem cells. PMID: 24564569 , Stem Cells & Development. 2014, 23(14): 1704-16.

Researcher : NG KP

List of Research Outputs

CHEN W., Ma C.W., DE NOGUEIRA BOTELHO F.P., NG K.P., HU H., Bai Z.T., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of inhibitory transmission in the vestibular nucleus during an early postnatal stage impacts on the thalamic spatial map and spatial cognitive behaviors., Proc. 16^th Conference of Neuropsychopharamcology Wenzhou. September 25-28, 2014]. 2014.

Chan Y.S., Ma C.W., Ng K.P., Han L. and Shum D.K.Y., Glutamatergic transmission in the vestibular nucleus is critical to the formation of spatial topography and acquisition of spatial navigation in rats behaviour, Society Neuroscience Abstract (USA), 157.01/EE3. 2014.

Chan Y.S., Ma C.W., Ng K.P., Han L. and Shum D.K.Y., Glutamatergic transmission in the vestibular nucleus is critical to the formation of spatial topography and acquisition of spatial navigation in rats, Soc. Neuroscience Abstract (USA) 157.01/EE3 [Washington DC. Nov. 15-19, 2014]. 2014.

Researcher : Ng KP

List of Research Outputs

Chan Y.S., Ma C.W., Ng K.P., Han L. and Shum D.K.Y., Glutamatergic transmission in the vestibular nucleus is critical to the formation of spatial topography and acquisition of spatial navigation in rats, Soc. Neuroscience Abstract (USA) 157.01/EE3 [Washington DC. Nov. 15-19, 2014]. 2014.

Researcher : Poon NYE

Project Title:	The effect of miR-200c on the electrophysiological maturation of human embryonic stem cell derived cardiomyocytes
Investigator(s):	Poon NYE, Boheler KR, Li RA
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2014

List of Research Outputs

Poon N.Y.E., Physical developmental cues for the maturation of human pluripotent stem cell-derived cardiomyocytes, Stem Cell Research & Therapy. 2014, 5: 117.

Researcher : Ren L

List of Research Outputs

CHEN G., LI S., Karakikes I., Ren L., Chow M.Z.Y., Chopra A., Keung W.W.Y., Yan B., Chan C.W.Y., Costa K.D., Kong M.C.W., Hajjar R.J., Chen C.S. and Li R.A., Phospholamban as a Crucial Determinant of the Inotropic Response of Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes and Engineered 3D Tissue Constructs, Circulation: Arrhythmia and Electrophysiology. 2014.

Karakikes I., Stillitano F., Nonnenmacher M., Tzimas C., Sanoudou D., Termglinchan V., Kong M.C.W., Rushing S., Hansen J., Ceholski D., Kolokathis F., Kremastinos D., Katoulis A., Ren L., Cohen N., Gho J.M.I.H., Tsiapras D., Vink A., Wu J.C., Asselbergs F.W., Li R.A., Hulot J.S., Kranias E.G. and Hajjar R.J., Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy, Nature Communications. 2015, 6: 6955.

Weng J.Z., Kong M.C.W., Ren L., Karakikes I., Geng L., HE J., Chow M.Z.Y., Mok C.F., Keung W.W.Y., Chow C.H., Leung A.Y.H., Hajjar R.J., Li R.A. and Chan C.W.Y., A simple, cost-effective but highly efficient system for deriving ventricular cardiomyocytes from human pluripotent stem cells. PMID: 24564569 , Stem Cells & Development. 2014, 23(14): 1704-16.

Researcher : SHI W

List of Research Outputs

JIANG Q., SHI W., DE NOGUEIRA BOTELHO F.P., Ma C.W., Lai C.H., Shum D.K.Y. and Chan Y.S., Developmental modulation of long-term plasticity at vestibular GABAergic synapses, Journal of Neurochemistry , 130 Suppl 1: 65. 2014.

LAM K.S.F., Ma C.W., DE NOGUEIRA BOTELHO F.P., Lai C.H., SHI W., Shum D.K.Y. and Chan Y.S., NKCC1 and KCC2 cotransporters are required in postnatal maturation of the vestibular system, Abstracts of 10th Int’l Symp. on Healthy Aging: 75. 2015.

Researcher : Shiu SYW

Project Title:	Interactions between androgen receptor (AR) and nuclear factor kappa B (NF-κB) signaling in prostate carcinogenesis
Investigator(s):	Shiu SYW
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013
Completion Date:	06/2015

Project Title:	Investigating potential signaling interactions between melatonin MT1 receptor and ‎melatonin-related GPR50 receptor, and profiling melatonin-induced genome-wide ‎transcriptional changes in prostate cancer ‎
Investigator(s):	Shiu SYW
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2014

Project Title:	Exploring melatonin receptor signaling in human retinal pigment epithelial cells
Investigator(s):	Shiu SYW
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	04/2015

Researcher : TAI WYE

List of Research Outputs

Shum D.K.Y., TAI W.Y.E., Shea G.H.K., Tsui Y.P., LEUNG H.Y. and Chan Y.S., Juxtacrine signalling via Notch and ErbB receptors in the switch to fate commitment of bone marrow-derived Schwann cells, Soc. Neuroscience Abstract (USA) 589.10/A21. 2014.

TAI W.Y.E., Shea G.K.H., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Guidance of DRG neurons in fate determination of bone marrow derived Schwann cells, 9th FENS Forum of Neuroscience. 2014.

TAI W.Y.E., Shea G.K., Leung K.H., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Instructive role of DRG neurons in derivation of Schwann cells from bone marrow stromal cells, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 57. 2015.

Tsui Y.P., TAI W.Y.E., Shum D.K.Y. and Chan Y.S., Cell therapy for remyelination: Divergent routs for derivation of alternative glial cell fates from adult bone marrow stromal cells, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging : 56. 2015.

Researcher : Tam KW

List of Research Outputs

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilization of chondroitinase ABC-I and –II on chitosan microbeads improve neurite growth in CSPG-enriched astrocyte culture, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 64. 2015.

TUNG W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Nere guidance channel constructed by Schwann cell seeded aligned chitosan nanofiber, Journal of Neurochemistry, 130 Suppl 1: 49. 2014.

Tam K.W., Chan Y.S. and Shum D.K.Y., Stability and kinetics of chondroitinase ABC in macromolecular crowded environment, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 64. 2015.

Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Nerve conduit constructed by aligned chitosan nanofibers for directing axonal growth in nerve regeneration, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 64. 2015.

Researcher : Tang F

List of Research Outputs

Wong P.F., Cheung M.P.L., O W.S. and Tang F., Intermedin inhibits norepinephrine - induced contraction of rat seminal vesicle, Asia Pacific Journal of Reproduction. 2014, 3(3): 176-179.

Researcher : Tsui YP

Project Title:	Axonal regulation of peripheral nervous system glia identity
Investigator(s):	Tsui YP, Chan YS
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2015

List of Research Outputs

Shum D.K.Y., TAI W.Y.E., Shea G.H.K., Tsui Y.P., LEUNG H.Y. and Chan Y.S., Juxtacrine signalling via Notch and ErbB receptors in the switch to fate commitment of bone marrow-derived Schwann cells, Soc. Neuroscience Abstract (USA) 589.10/A21. 2014.

TAI W.Y.E., Shea G.K.H., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Guidance of DRG neurons in fate determination of bone marrow derived Schwann cells, 9th FENS Forum of Neuroscience. 2014.

TAI W.Y.E., Shea G.K., Leung K.H., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Instructive role of DRG neurons in derivation of Schwann cells from bone marrow stromal cells, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 57. 2015.

Tsui Y.P., Shum D.K.Y. and Chan Y.S., Cell therapy for myelin disorder: derivation of two myelin-forming cell types from adult bone marrow stromal cells , Tenth International Symposium on Healthy Aging “A Decade of Positive Aging”. 2015.

Tsui Y.P., TAI W.Y.E., Shum D.K.Y. and Chan Y.S., Cell therapy for remyelination: Divergent routs for derivation of alternative glial cell fates from adult bone marrow stromal cells, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging : 56. 2015.

Tsui Y.P., Shum D.K.Y. and Chan Y.S., Divergent routes for derivation of alternative glial cell fate from adult bone marrow stromal cells for remyelination therapy, Gordon Research Conference - Molecular & Cellular Neurobiology. 2014.

Tsui Y.P., Shum D.K.Y. and Chan Y.S., Sun Chieh Yeh Young Investigator Award (Oral Category), Tenth International Symposium on Healthy Aging: A Decade of Positive Aging, Hong Kong, China. 2015.

Researcher : Wang Y

Project Title:	Structural basis of sirt6 catalytic mechanism investigation and the inhibitors design
Investigator(s):	Wang Y, Hao Q
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2015

Project Title:	Biology of Sirtuins, Keystone Symposia; Structural basis of human Sirtuins' novel function in epigenetics
Investigator(s):	Wang Y
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2015
Completion Date:	03/2015

List of Research Outputs

BAO X., Wang Y., LI X., LI X., LIU Z., YANG T., Wong C.F., Zhang J., Hao Q. and Li X., Identification of ‘erasers’ for lysine crotonylated histone marks using a chemical proteomics approach, eLife. 2014, 3.

Researcher : Wei W

Project Title:	The 4th Annual Cambridge Stem Cell International Symposium: 'Stem Cells in Medicine'; CD38 modulates the neural differentiation of mouse embryonic stem cells through NADPH oxidase-ROS related pathway
Investigator(s):	Wei W
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2014
Completion Date:	07/2014

Researcher : Weng JZ

List of Research Outputs

Weng J.Z., Kong M.C.W., Ren L., Karakikes I., Geng L., HE J., Chow M.Z.Y., Mok C.F., Keung W.W.Y., Chow C.H., Leung A.Y.H., Hajjar R.J., Li R.A. and Chan C.W.Y., A simple, cost-effective but highly efficient system for deriving ventricular cardiomyocytes from human pluripotent stem cells. PMID: 24564569 , Stem Cells & Development. 2014, 23(14): 1704-16.

Researcher : Wong PF

List of Research Outputs

Wong P.F., Cheung M.P.L., O W.S. and Tang F., Intermedin inhibits norepinephrine - induced contraction of rat seminal vesicle, Asia Pacific Journal of Reproduction. 2014, 3(3): 176-179.

Researcher : Wong TM

Project Title:	First Asia-Pacific Opioid Symposium Cardioprotective Effects of K-Opioids
Investigator(s):	Wong TM
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2000

Project Title:	XVIII World Congress International Society for Heart Research in Conjunction with 52nd Annual Scientific Meeting of the Cardiac Society of Australia & New Zealand Delayed Cardioprotection of Kappa Opioid Receptor Stimulation in Normal and Diabetic Rats - Roles of Heat Shock Protein 70 and Intracellular Ca2+
Investigator(s):	Wong TM
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2004

Project Title:	CSANZ 2006 Annual Scientific Meeting Heat Shock Protein 70, Calcium Regulation and Cardiac Survival
Investigator(s):	Wong TM
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2006

Researcher : Yan B

List of Research Outputs

CHEN G., LI S., Karakikes I., Ren L., Chow M.Z.Y., Chopra A., Keung W.W.Y., Yan B., Chan C.W.Y., Costa K.D., Kong M.C.W., Hajjar R.J., Chen C.S. and Li R.A., Phospholamban as a Crucial Determinant of the Inotropic Response of Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes and Engineered 3D Tissue Constructs, Circulation: Arrhythmia and Electrophysiology. 2014.

Guan D., Boheler K.R., Wang J.J. and Yan B., PTHGRN: unraveling post-translational hierarchical gene regulatory networks using PPI, ChIP-seq and gene expression data, Nucleic Acids Research. UK, Oxford Journal, 2014, 12: W131-136.

Ho V.W., Wong M.K., An X., Guan D., Shao J., Ng H.C., Ren X., He K., Liao J., Ang Y., Chen L., Huang X., Yan B., Xia Y., Chan L.L., Chow K.L., Yan H. and Zhao Z., Systems-level quantification of division timing reveals a common genetic architecture controlling asynchrony and fate asymmetry, Mol Syst Biol. 2015, 11(6): 814.

Li M.L., Yan B., Sham P.C. and Wang J.J., Exploring the function of genetic variants in the non-coding genomic regions: approaches for identifying human regulatory variants affecting gene expression, Briefings in Bioinformatics. UK, Oxford Journal, 2015, 16: 393-412.

Malik N., Wang X., Shah S., Efthymiou A.G., Yan B., Heman-Ackah S., Zhan M. and Rao M., Comparison of the gene expression profiles of human fetal cortical astrocytes with pluripotent stem cell derived neural stem cells identifies human astrocyte markers and signaling pathways and transcription factors active in human astrocytes, PLoS One. 2014, 9(5): e96139.

QIN Y., YALAMANCHILI H.K., Qin J., Yan B. and Wang J.J., The Current Status and Challenges in Computational Analysis of Genomic Big Data, Big Data Research. 2015, 2: 12-18.

Yan B., Editorial Board Of Journal Of Biotechnology Science Research, 2014.

Zhao P., Liu P., Shao J., Li C., Wang B., Guo X., Yan B., Xia Y. and Peng M., Analysis of different strategies adapted by two cassava cultivars in response to drought stress: ensuring survival or continuing growth, J Exp Bot. 2015, 66(5): 1477-88.

Researcher : Yang L

List of Research Outputs

Chen K., Liu H., Yang L., Jin M.W. and Li G.R., SKF-96365 strongly inhibits voltage-gated sodium current in rat ventricular myocytes, Pflügers Archiv - European Journal of Physiology. 2014.

Yang L., Liu H., Sun H. and Li G.R., Intravenous Anesthetic Propofol Inhibits Multiple Human Cardiac Potassium Channels, Anesthesiology. 2014, 122(3): 571-84.

Researcher : Yeung HM

List of Research Outputs

Yeung H.M., Hung M.W., Lau C.F. and Fung M.L., Cardioprotective effects of melatonin against myocardial injuries induced by chronic intermittent hypoxia in rats, Journal of Pineal Research. 2014, 58(1): 12-25.

Researcher : Yue J

Project Title:	The role of NAADP/two-pore channel 2/Ca2+ signaling in regulating neural differentiation of mouse embryonic stem cells
Investigator(s):	Yue J, Wu W
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2011

Project Title:	The Calcium Signaling Pathway Mediated by NAADP.
Investigator(s):	Yue J, Lee HC, Cheung KH
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2012
Completion Date:	10/2014

Project Title:	Role of TRPM2/ADPR/Ca2+ signaling in self-renewal and neurogenesis of mouse neural stem cells
Investigator(s):	Yue J
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2013
Completion Date:	11/2014

Project Title:	2013 ASBMB Annual Meeting; The NAADP/ TPC2/Ca2+ Signaling Antagonizes Autophagosome Maturation
Investigator(s):	Yue J
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2013

Project Title:	Dissecting the Mechanism and Function of TPC2 Signaling in Autophagy Maturation in Mammalian Cells
Investigator(s):	Yue J, Wu W
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2013

Project Title:	Dissecting NAADP signaling network by combining approaches of proteomics and synthetic organic chemistry
Investigator(s):	Yue J
Department:	Physiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2014
Completion Date:	10/2014

Project Title:	Applying a Novel cADPR Photoaffinity Labelling Analogue to Dissect the Cyclic ADP-Ribose (cADPR)-Ca2+ Signaling in Mammalian Cells
Investigator(s):	Yue J, Cheung KH
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2014

Researcher : ZHANG W

List of Research Outputs

ZHANG W., Zhang T., Zhang H. and Hao Q., Crystallographic phasing with NMR models: an envelope approach, Acta Crystallographica Section D Biological Crystallography. 2014, 70: 1977-1982.

Researcher : Zhang H

List of Research Outputs

Swarbrick J.M., Graeff R.M., Zhang H., Thomas M.P., Hao Q. and Potter B.V.L., Cyclic Adenosine 5′-Diphosphate Ribose Analogs without a “Southern” Ribose Inhibit ADP-ribosyl Cyclase–Hydrolase CD38, Journal of Medicinal Chemistry. 2014, 57: 8517-8529.

ZHANG W., Zhang T., Zhang H. and Hao Q., Crystallographic phasing with NMR models: an envelope approach, Acta Crystallographica Section D Biological Crystallography. 2014, 70: 1977-1982.

Researcher : Zhao Y

Project Title:	Characteristics and potential regulatory mechanisms of a cytosolic CD38
Investigator(s):	Zhao Y, Lee HC
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2011

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