DEPT OF PATHOLOGY
| Researcher : Au LKS |
| List of Research Outputs |
| Tsang F.H., Au L.K.S., Fan N.Y., Lee M.F., Wong C.C.L., Ng I.O.L. and Wong C.M., HOTTIP, an oncogenic long non-coding RNA, is frequently up-regulated in hepatocellular carcinoma and is negatively regulated by tumor suppressive microRNA miR-125b, Liver International. 2015, 35: 1597. |
| Wong C.C.L., Tse P.W., Huang Y., Zhu Y., CHIU K.C., LAI K.H., Au L.K.S., Kai A.K.L., Lee M.F., WEI L., Tsang F.H., Lo C.L.R., Shi J., Zheng Y., Wong C.M. and Ng I.O.L., Lysyl Oxidase-like 2 Is Critical To Tumor Microenvironment And Metastatic Niche Formation In Hepatocellular Carcinoma, In: Snorry Thorgeirsen, Hepatology. 2014. |
| Wong C.C.L., Au L.K.S., Tse P.W., Xu M., LAI K.H., CHIU K.C., WEI L., Fan N.Y., Tsang F.H., Lo C.L.R., Wong C.M. and Ng I.O.L., Switching of pyruvate kinase isoform L to M2 promotes metabolic reprogramming in hepatocarcinogenesis, PLos One. 2014. |
| Wong C.M., WEI L., Au L.K.S., Fan N.Y., Zhou Y., Tsang F.H., Lee M.F., He X., Shi J., Wong C.C.L. and Ng I.O.L., miR-200b/200c/429 subfamily negatively regulates Rho/ROCK signaling pathway and suppresses HCC metastasis, Oncotarget . 2015, 6: 13658. |
| Researcher : Au YLE |
| List of Research Outputs |
| Au Y.L.E., Wong R.W.S., Mok T.M.Y., Chung H.Y., Chan Y.T.E. and Lau W.C.S., Disease activity assessment in ankylosing spondylitis in a Chinese cohort: BASDAI or ASDAS?, Clinical Rheumatology . 2014, 33: 1127-1134. |
| Researcher : Au Yeung KHR |
| Project Title: | Identification of tumor suppressor receptor-type protein tyrosine phosphatases (R-PTPases) in nasal-type NK/T-cell lymphoma, and evaluation of their role as novel prognostic indicators and drug targets |
| Investigator(s): | Au Yeung KHR, Srivastava G |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Au Yeung K.H.R., Best Presentation Award for the presentation of 'Receptor-type tyrosine-protein phosphatase kappa promoter hypermethylation correlates with unfavorable prognosis in nasal NK/T-cell lymphoma patients treated with SMILE regimen', The 60th Autumn Annual Meeting of the Japanese Society of Pathology. Japan, 2014. |
| Au Yeung K.H.R., Molecular pathogenesis and targeting of nasal-type NK/T cell lymphoma, Tohoku Medical Society. 東北医学会, 2014. |
| Au Yeung K.H.R., Chen W.Y.W., Guo T., Wong K.Y., Shimizu N., Tsuchiyama J., Loong F., Kwong Y.L. and Srivastava G., Receptor-type tyrosine-protein phosphatase kappa promoter hypermethylation correlates with unfavorable prognosis in nasal NK/T-cell lymphoma patients treated with SMILE regimen, The 60th Autumn Annual Meeting of the Japanese Society of Pathology. 第60回日本病理学会秋期特別総会, Japan, 2014. |
| Chen W.Y.W., Guo T., Shen L., Wong K.Y., Tao Q., Choi W.L., Au Yeung K.H.R., Chan Y.P., Wong M.L.Y., Tang J.C.O., Liu W.P., Li G.D., Shimizu N., Loong F., Tse E.W.C., Kwong Y.L. and Srivastava G., Receptor-type tyrosine-protein phosphatase k directly targets STAT3 activation for tumor suppression in nasal NK/T-cell lymphoma, Blood. United States of America, The American Society of Hematology, 2015, 125(10): 1589-600. |
| Liu A.P.Y., Chang K.O., Au Yeung K.H.R., Chan A. and Chan G.C.F., Succinate Dehydrogenase Subunit B (sdhb) Gene Mutations In Paediatric Metastatic Paraganglioma: A Report Of Two Cases, Hong Kong College of Paediatricians Annual Scientific Meeting 2014. |
| Tsang J.S., Chok K.S.H., Au Yeung K.H.R. and Lo C.M., Combined sarcomatoid hepatocellular and cholangiocarcinoma: a case report and literature review, Hepatoma Research. Asia-Pacific Association of Medical Research, 2015, 1: 41. |
| Researcher : Beh SL |
| Project Title: | The attitudes of doctors toward rape victims |
| Investigator(s): | Beh SL |
| Department: | Pathology |
| Source(s) of Funding: | Other Funding Scheme |
| Start Date: | 06/1993 |
| List of Research Outputs |
| Beh S.L., Comparison Between The Coroner's System And The Medical Examiners System Of Death Investigation, 23rd Congress Of The International Academy Of Legal Medicine. 2015. |
| Beh S.L. and Byard R.W., Diphtheria And Lethal Upper Airway Obstruction, Forensic Science, Medicine, and Pathology. 2015, 11: 133-135. |
| Beh S.L., Disaster Response In Hong Kong, World Forensic Festival 2014. 2014. |
| Chan S.Y.T., Hwang Y.Y.G., Singh G.H.H., Cheung C.W.S., Ting A.C.W., Beh S.L., Kwong Y.L. and Tse E.W.C., Increasing incidence of venous thromboembolism due to cancer-associated thrombosis in Hong Kong Chinese, Thrombosis Research. 2014. |
| Hamilton S. and Beh S.L., Forensic Science In Hong Kong, In: Douglas H. Ubelaker, The Global Practice Of Forensic Science. Wiley Blackwell, 2015. |
| Researcher : CHENG YLB |
| List of Research Outputs |
| LO J., Ching H.H., Lau Y.T., CHENG Y.L.B., MA K.F., Lee K.W. and Ng I.O.L., Nuclear Factor Kappa B–mediated Cd47 Up-regulation Promotes Sorafenib Resistance And Its Blockade Synergizes The Effect Of Sorafenib In Hepatocellular Carcinoma In Mice, Hepatology. 2015. |
| Researcher : CHIU KC |
| List of Research Outputs |
| Wong C.C.L., Tse P.W., Huang Y., Zhu Y., CHIU K.C., LAI K.H., Au L.K.S., Kai A.K.L., Lee M.F., WEI L., Tsang F.H., Lo C.L.R., Shi J., Zheng Y., Wong C.M. and Ng I.O.L., Lysyl Oxidase-like 2 Is Critical To Tumor Microenvironment And Metastatic Niche Formation In Hepatocellular Carcinoma, In: Snorry Thorgeirsen, Hepatology. 2014. |
| Wong C.C.L., Au L.K.S., Tse P.W., Xu M., LAI K.H., CHIU K.C., WEI L., Fan N.Y., Tsang F.H., Lo C.L.R., Wong C.M. and Ng I.O.L., Switching of pyruvate kinase isoform L to M2 promotes metabolic reprogramming in hepatocarcinogenesis, PLos One. 2014. |
| Researcher : Chan GSW |
| List of Research Outputs |
| Wong H., Hwang Y.Y., Leung R.Y.Y., Chan G.S.W., Khong P.L. and Kwong Y.L., Unilateral hearing loss due to lymphocytosis and a contralateral putamen lesion, Annals of Hematology. 2015, 94: 703-704. |
| Researcher : Chan KK |
| Project Title: | Autophagy in the chemoresistance of ovarian tumor-initiating cell |
| Investigator(s): | Chan KK, Cheung ANY |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2013 |
| Project Title: | iASPP and autophagy - novel molecular targets for ovarian clear cell carcinoma |
| Investigator(s): | Chan KK, Cheung ANY, Wong GW, Chan KKL |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2014 |
| List of Research Outputs |
| Chan K.K., Murray J.A.M.E.S. .T., Yuen H.F. and Cheung A.N.Y., Effect Of Autophagy On Stemness In Ovarian Clear Cell Carcinoma, Frontiers In Cancer Biology And Drug Development. 2015. |
| Cheung A.N.Y., Wong G.W., Chan K.K., Yang M.S., Tsang C.H., Ji S.L., Lo C.K., Szeto E., Wong E.S.Y. and Ngan H.Y.S., Integrated human papillomavirus analysis as an adjunct for triage of atypical cervical cytology, In: ANY Cheung, OG Wong, KKY Chan, MS Yang, CH Tsang, SL Ji, CK Lo, E Szeto, E Wong, HYS Ngan, Hong Kong Med J. 2014. |
| Kwok A.L., Wong G.W., Wong E.S.Y., Tsun O.K.L., Chan K.K. and Cheung A.N.Y., Caution over use of ES2 as a model of ovarian clear cell carcinoma., J Clin Pathol . 2014, 67: 921-2. |
| Mak C.Y., Wong G.W., Siu K.Y., Wong E.S.Y., Ngan W.Y., Wong R.W., Chan K.K., Ngan H.Y.S. and Cheung A.N.Y., FBI-1 Is Overexpressed in Gestational Trophoblastic Disease and Promotes Tumor Growth and Cell Aggressiveness of Choriocarcinoma via PI3K/Akt Signaling., Am J Pathol. 2015, 185(7): 2038-48. |
| Researcher : Chan KW |
| Project Title: | Identification, Characterization and Therapeutic Targeting of Tumourigenic Liver Cancer Stem Cells |
| Investigator(s): | Chan KW, Guan X |
| Department: | Pathology |
| Source(s) of Funding: | Michael and Betty Kadoorie Cancer Genetics Research Programme (MBKCGRP) II |
| Start Date: | 01/2008 |
| Project Title: | Functional characterization and evaluation of the metastasis promoting effect of neuropilin-2 (NRP2) in esophageal squamous cell carcinoma |
| Investigator(s): | Chan KW, Ma SKY, Law SYK |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2013 |
| Project Title: | A new tumor suppressor gene KIF7 inhibits tumor progression by suppressing Wnt/beta-catenin signaling in prostate cancer |
| Investigator(s): | Chan KW, Liu J |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2015 |
| List of Research Outputs |
| Cheung A., XU W., Li B., Tsao G.S.W. and Chan K.W., Role of Id1-IGF2-VEGF-VEGFR relay in esophageal tumorigenesis, 23rd Biennial Congress of the European Association for Cancer Research, July 5-8, 2014 Munich, Germany.. 2014, 50 suppl. 5: S35 No. 161. |
| Cheung A., HAN L., Li B., Tsao G.S.W., Law S.Y.K., Chan K.W. and Lam A.K.Y., Role of miR-338-5p as a novel modulator of chemoresistannce in esophageal cancer, EACR AACR SIC Conference, June 20-23, Florence Italy. 2015. |
| Huang Y., Zhang S.D., McCrudden C., Chan K.W., Lin Y. and Kwok H.F., The prognostic significance of PD-L1 in bladder cancer, Oncology Reports. 2015, 33(6): 3075-84. |
| Ip J.C.Y., Ko J.M.Y., Yu Z., Chan K.W., Lam A.K., Law S.Y.K., Tong D.K.H. and Lung M.L., A Versatile Orthotopic Nude Mouse Model for Study of Esophageal Squamous Cell Carcinoma, In: Dominic Fan, BioMed Research International. New York, USA, Hindawi Publishing Corporation, 2015, 2015. |
| Ip J.C.Y., Ko J.M.Y., Yu Z., Chan K.W., Lam A.K.Y., Law S.Y.K., Tong D.K.H. and Lung M.L., Establishment of an orthotopic oesophageal squamous cell carcinoma animal model visualised by bioluminescence imaging and recapitulating the tumour-stromal microenvironment, 19th Research Postgraduate Symposium HKU, Hong Kong. 2014. |
| Kang Y.L., Saleem M.A., Chan K.W., Yung B.Y. and Law H.K., Trehalose alleviates human podocyte injury via the induction of autophagy in an mTOR independent manner, The XII Asian Congress of Pediatric Nephrology, 4-6 December 2014, New Delhi, India. 2014. |
| Kang Y.L., Saleem M.A., Chan K.W., Yung B.Y. and Law H.K., Trehalose, an mTOR Independent Autophagy Inducer, Alleviates Human Podocyte Injury after Puromycin Aminonucleoside Treatment, PLoS ONE. 2014, 9: e113520. |
| Li B., HAN L., Chan K.W., Law S., Lam A.K.Y., Tsao G.S.W. and Cheung A., Suppressive effects of Id1-targeting microRNAs in metastasis of esophageal cancer, 21st Hong Kong International Cancer Congress, November 21, 2014, Hong Kong.. 2014, No. A17. |
| Tong M., Fung T.M., Luk T.C.S., Ng K.Y., Lee K.W., Lin C., Yam J.W.P., Chan K.W., Ng F., Zheng B., Yuan Y.F., Xie D., Lo C.M., Man K., Guan X. and Ma S.K.Y., ANXA3/JNK Signaling Promotes Self-Renewal and Tumor Growth, and Its Blockade Provides a Therapeutic Target for Hepatocellular Carcinoma, Stem Cell Reports. 2015. |
| XU W., Li B., Tsao G.S.W., Chan K.W. and Cheung A., IGI-induced IGF2 promotes esophageal cancer progression through instigation of stromal fibroblasts and bone marrow-drived vancular progenitor cells, 21st Hong Kong International Cancer Congress, November 21, 2014 Hong Kong. 2014, No. A11. |
| XU W., Li B., Lam A.K.Y., Tsao G.S.W., Law S.Y.K., Chan K.W., Yuan Q. and Cheung A., Targeting VEGFR-1 and VEGFR2-expressing non-tumor cells is essential for esophageal cancer therapy, Oncotarget. 2014, 6(3): 1790-1805. |
| Yung S.S.Y., Ng C.Y., Ho S.K., Cheung K.F., Chan K.W., Zhang Q., Chau K.M. and Chan D.T.M., Anti-dsDNA antibody induces soluble fibronectin secretion by proximal renal tubular epithelial cells and downstream increase of TGF-β1 and collagen synthesis, Journal of Autoimmunity. 2015, 58: 111-122. |
| Researcher : Chan LC |
| Project Title: | To develop a pilot humanities program in the first year undergraduate medical curriculum 2007-2008. |
| Investigator(s): | Chan LC |
| Department: | Pathology |
| Source(s) of Funding: | Leung Kau Kui Research and Teaching Endowment Fund - Teaching Grants |
| Start Date: | 08/2007 |
| List of Research Outputs |
| Chan L.C., 3rd Asia Pacific Joint Conference on Problem-Based Learning. Phuket, Thailand. 4-7 December 2014. 2014. |
| Chan L.C., Bringing Medical Humanities to the Health Sciences Curriculum – why, what and how, Royal College of Medicine Perak, University of Kuala Lumpur, Malaysia. 2 April 2015. 2015. |
| Chan L.C. and Chen J.Y., Establishing a core medical humanities program in an undergraduate medical curriculum, Universitas 21 Health Sciences Group. 2014. |
| Chan L.C., Joint Universiti Kebangsaan Malaysia (UKM) – University of Hong Kong (HKU) Public Lecture: Meeting of Minds. Universiti Kebangsaan Malaysia, Malaysia. 17 March 2015. 2015. |
| Chan L.C., Speaker, The International Convention on Challenges in Medical Education. Mahatma Gandhi Missions Medical College, Aurangabad, India. 9-11 January 2015. 2015. |
| Chan L.C., Symposium “Religion and Professionalism”. 3rd Conference of the South East Asian Regional Association of Medical Education and 2nd Conference of the Forum of Sri-Lankan Medical Educationists. Colombo, Sri Lanka. 12-15 November 2014. 2014. |
| Lam Y.M., Chan L.C. and Ng R.K., BMI-1 negatively regulates JAK-STAT signaling in leukemia, EMBO workshop: Stem cells and Epigenetics in Cancer October 16-18, 2014, Hong Kong. 2014. |
| Wong G.T.C., Jenkins C.R., Tsang J.W.H., Chen J.Y., Chan L.C. and Tanner J.A., Finalist for Best Free Communication , Asia Pacific Medical Education Conference. 2015. |
| Wong G.T.C., Jenkins C.R., Tsang J.W.H., Chen J.Y., Chan L.C. and Tanner J.A., Use of film to build student empathy and enable reflective thought in a new Medical Humanities programme embedded within the undergraduate MBBS curriculum., 12th Asia Pacific Medical Education Conference, Singapore (awarded Finalist prize in the Free Communication Session) (2015). 2015. |
| Wong G.T.C., Jenkins C.R., Tsang J.W.H., Chen J.Y., Chan L.C. and Tanner J.A., Use of film to build student empathy and enable reflective thought, Asia Pacific Medical Education Conference. 2015. |
| Wong P.Y., Chan L.C., Chen J.Y. and Ho R.T.H., Finalist Best Poster Presentation, Asia Pacific Medical Education Conference. 2015. |
| Researcher : Chan LK |
| List of Research Outputs |
| Ma W., Sze M.F., Chan L.K., Lee M.F., Lee K.W., Wong C.C.L. and Ng I.O.L., RhoE/ROCK signaling modulates chemoresistance in HCC through IL6/JAK2/STAT3 pathways, New Horizons in Cancer Research Conference: Harnessing Breakthroughs – Targeting Cures. 2014. |
| Ma W., Sze M.F., Chan L.K., Lee M.F., Lee K.W., Wong C.C.L. and Ng I.O.L., Scholar-in-Training Award, New Horizons in Cancer Research Conference: Harnessing Breakthroughs – Targeting Cures (American Association for Cancer Research). 2014. |
| Researcher : Chan TL |
| Project Title: | Molecular characterisation of the serrated neoplasia pathway and its role in the development of colorectal cancer with mismatch repair deficiency |
| Investigator(s): | Chan TL, Leung SY, Yuen ST |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2005 |
| Project Title: | Outstanding Young Researcher Award 2007-2008 |
| Investigator(s): | Chan TL |
| Department: | Pathology |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 10/2008 |
| Project Title: | The role of DNA methylation in chromosomal instability in early onset Colorectal Cancer |
| Investigator(s): | Chan TL |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2012 |
| Researcher : Chan WY |
| Project Title: | The biological and genetic determinants of seasonal influenza A virus replication in the lower respiratory tract |
| Investigator(s): | Chan WY, Chan MCW, Yen H, Nicholls JM, Peiris JSM |
| Department: | Pathology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 02/2011 |
| Completion Date: | 09/2014 |
| Project Title: | Neutrophil mediated host-responses during influenza A virus infection, an in vitro study |
| Investigator(s): | Chan WY, Chan MCW, Shum DKY, Nicholls JM, Peiris JSM |
| Department: | Pathology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 03/2012 |
| Project Title: | The application of swine and human respiratory organ explant cultures to investigate inter-species transmission of avian influenza viruses to swine and humans |
| Investigator(s): | Chan WY, Chan MCW, Nicholls JM, Peiris JSM |
| Department: | School of Public Health |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2013 |
| Project Title: | Influenza B virus induced host innate immune response in human primary alveolar epithelial cells |
| Investigator(s): | Chan WY |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2013 |
| Completion Date: | 06/2015 |
| Project Title: | Human lung local immunity to influenza virus - role of lung antibody and resident memory T cells |
| Investigator(s): | Chan WY, Tu W, Nicholls JM, Peiris JSM |
| Department: | School of Public Health |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Completion Date: | 04/2015 |
| Project Title: | Influenza B viruses: Virus tropism in human and swine respiratory organ explant cultures and sero-epidemiology in swine |
| Investigator(s): | Chan WY, Chan MCW, Nicholls JM, Peiris JSM |
| Department: | School of Public Health |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2014 |
| Project Title: | Is the loss of glycosylation in haemagglutinin protein a strategy for influenza virus to adapt in pigs? |
| Investigator(s): | Chan WY |
| Department: | School of Public Health |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Completion Date: | 04/2015 |
| Researcher : Chan YF |
| List of Research Outputs |
| Lui W.C., Chan Y.F. and Ng R.K., PRMT1 activates leukemic stem cell program in MLL-rearranged leukemia, 56th ASH Annual Meeting and Exposition December 6-9, 2014, San Francisco, United States. 2014. |
| Researcher : Chan YK |
| Project Title: | Validating and examining SNPs identified from genome-wide scanning for disease susceptibility to HBV-related liver cancer in Chinese population |
| Investigator(s): | Chan YK, Ng IOL, Wong CM |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2010 |
| List of Research Outputs |
| Cai Q., Zhang B., Sung H., Low S.K., Kweon S.S., Lu W., Shi J., Long J., Wen W., Choi J.Y., Noh D.Y., Shen C.Y., Matsuo K., Teo S.H., Kim M.K., Khoo U.S., Iwasaki M., Hartman M., Takahashi A., Ashikawa K., Matsuda K., Shin M.H., Park M.H., Zheng Y., Xiang Y.B., Ji B.T., Park S.K., Wu P.E., Hsiung C.N., Ito H., Kasuga Y., Kang P., Mariapun S., Ahn S.H., Kang H.S., Chan Y.K., Man P.S., Iwata H., Tsugane S., Miao H., Liao J., Nakamura Y., Kubo M., Consortium D.G., Delahanty R.J., Zhang Y., Li B., Li C., Gao Y.T., Shu X.O., Kang D. and Zheng W., Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1, Nat Genet. 2014, 46(8): 886-90. |
| Liu S., Chan Y.K., Leung C.Y., Yip M.W., Lau S.K., Liao X.Y., Jiang L.L., Luk M.H.M., Lo S.S., Cheung A.N.Y., Lin Z.Q. and Ngan H.Y.S., Human papillomavirus status in southern Chinese women, Hong Kong Med J. 2014, 2014;20(Suppl 6):S35-8. |
| Researcher : Chan YP |
| List of Research Outputs |
| Chen W.Y.W., Guo T., Shen L., Wong K.Y., Tao Q., Choi W.L., Au Yeung K.H.R., Chan Y.P., Wong M.L.Y., Tang J.C.O., Liu W.P., Li G.D., Shimizu N., Loong F., Tse E.W.C., Kwong Y.L. and Srivastava G., Receptor-type tyrosine-protein phosphatase k directly targets STAT3 activation for tumor suppression in nasal NK/T-cell lymphoma, Blood. United States of America, The American Society of Hematology, 2015, 125(10): 1589-600. |
| Researcher : Chan YTE |
| List of Research Outputs |
| Au Y.L.E., Wong R.W.S., Mok T.M.Y., Chung H.Y., Chan Y.T.E. and Lau W.C.S., Disease activity assessment in ankylosing spondylitis in a Chinese cohort: BASDAI or ASDAS?, Clinical Rheumatology . 2014, 33: 1127-1134. |
| Chan Y.T.E., Ho H.K., Lai C.K.W., Lau W.C.S., Lau Y.L., Lee T.H., Leung T.F., Wong G.W.K. and Wu Y.Y., Allergy in Hong Kong: an unmet need in service provision and training, Hong Kong Medical Journal. 2015. |
| Researcher : Chen SPL |
| List of Research Outputs |
| Lam C.W., Law C.Y., Leung K.F., Lai C.K., Chen S.P.L., Chan B., Chan K.Y., Yuen L.Y.P., Mak C.M. and Chan A.Y.W., NMR-based urinalysis for rapid diagnosis of β-ureidopropionase deficiency in a patient with Dravet syndrome, Clinica Chimica Acta. 2015, 440: 201-204. |
| Researcher : Chen WYW |
| Project Title: | Doris Zimmern HKU-Cambridge Hughes Hall Fellowships 2010-11 |
| Investigator(s): | Chen WYW |
| Department: | Pathology |
| Source(s) of Funding: | Doris Zimmern HKU-Cambridge Hughes Hall Fellowships |
| Start Date: | 09/2010 |
| List of Research Outputs |
| Au Yeung K.H.R., Chen W.Y.W., Guo T., Wong K.Y., Shimizu N., Tsuchiyama J., Loong F., Kwong Y.L. and Srivastava G., Receptor-type tyrosine-protein phosphatase kappa promoter hypermethylation correlates with unfavorable prognosis in nasal NK/T-cell lymphoma patients treated with SMILE regimen, The 60th Autumn Annual Meeting of the Japanese Society of Pathology. 第60回日本病理学会秋期特別総会, Japan, 2014. |
| Chen W.Y.W., Guo T., Shen L., Wong K.Y., Tao Q., Choi W.L., Au Yeung K.H.R., Chan Y.P., Wong M.L.Y., Tang J.C.O., Liu W.P., Li G.D., Shimizu N., Loong F., Tse E.W.C., Kwong Y.L. and Srivastava G., Receptor-type tyrosine-protein phosphatase k directly targets STAT3 activation for tumor suppression in nasal NK/T-cell lymphoma, Blood. United States of America, The American Society of Hematology, 2015, 125(10): 1589-600. |
| Researcher : Cheng L |
| List of Research Outputs |
| LIU J., Yeung P.K.K., Cheng L., Lo A.C.Y., Chung S.M. and Chung S.K., Epac2-deficiency leads to more severe retinal swelling, glial reactivity and oxidative stress in transient middle cerebral artery occlusion induced ischemic retinopathy, In: LIU Jin, YEUNG Patrick Ka Kit, CHENG Lu, LO Amy Cheuk Yin,CHUNG Stephen Sum Man & CHUNG Sookja Kim, Science China Life Sciences. 2015. |
| Researcher : Cheung ANY |
| Project Title: | Selecting most suitable students for production of best medical doctors-which criteria should we use? |
| Investigator(s): | Cheung ANY, Patil NG, Ip MSM, Chan LC |
| Department: | Pathology |
| Source(s) of Funding: | Leung Kau Kui Research and Teaching Endowment Fund - Teaching Grants |
| Start Date: | 02/2005 |
| Project Title: | Folate and folate receptor alpha in ovarian cancers |
| Investigator(s): | Cheung ANY, Siu KY |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2007 |
| Project Title: | Akt and p21-activated kinase signaling pathways in gestational trophoblastic disease |
| Investigator(s): | Cheung ANY, Ngan HYS, Siu KY |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2007 |
| Project Title: | Centre for Research into Circulating Fetal Nucleic Acids |
| Investigator(s): | Cheung ANY |
| Department: | Pathology |
| Source(s) of Funding: | Areas of Excellence Scheme |
| Start Date: | 01/2008 |
| Project Title: | FBI-1 in ovarian carcinogenesis and progression |
| Investigator(s): | Cheung ANY, Siu KY, Ngan HYS |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2009 |
| Project Title: | HPV detection as an adjunct for triage of atypical cervical cytology in screening for cervical cancer |
| Investigator(s): | Cheung ANY |
| Department: | Pathology |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 11/2009 |
| Project Title: | Tumour Microenvironment - New concepts and molecular mechanisms |
| Investigator(s): | Cheung ANY, Ng IOL, Khoo US, Lung ML, Ngan HYS |
| Department: | Pathology |
| Source(s) of Funding: | Croucher Advanced Study Institute |
| Start Date: | 01/2012 |
| Project Title: | HPV detection as an adjunct for triage of atypical cervical cytology in screening for cervical cancer |
| Investigator(s): | Cheung ANY, Ngan HYS |
| Department: | Pathology |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 02/2012 |
| Project Title: | Outstanding Research Student Supervisor Award 2011-12 |
| Investigator(s): | Cheung ANY |
| Department: | Pathology |
| Source(s) of Funding: | Outstanding Research Student Supervisor Award |
| Start Date: | 01/2013 |
| Project Title: | Apoptosis stimulating proteins of p53 and gestational trophoblastic disease |
| Investigator(s): | Cheung ANY, Ngan HYS, Wong GW |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2013 |
| Project Title: | 3rd Biennial Meeting of Asian Society of Gynecologic Oncology; Pathology of endometrial cancer and its precursor |
| Investigator(s): | Cheung ANY |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 12/2013 |
| Project Title: | Placental biology of Down Syndrome in relation to increased gene dosage |
| Investigator(s): | Cheung ANY, Wong GW, Ngan HYS |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2014 |
| Project Title: | p53 related proteins and gestational trophoblastic disease |
| Investigator(s): | Cheung ANY, Wong GW, Ngan HYS |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2014 |
| Project Title: | AMPK and metabolism in choriocarcinoma |
| Investigator(s): | Cheung ANY, Chan KK |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | NANOG and chemoresistance of ovarian cancer-initiating cells |
| Investigator(s): | Cheung ANY |
| Department: | Pathology |
| Source(s) of Funding: | Croucher Senior Medical Research Fellowships |
| Start Date: | 01/2015 |
| Project Title: | Nanog in ovarian cancer metabolism |
| Investigator(s): | Cheung ANY, Chan KK, Wong GW |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Chan K.K., Murray J.A.M.E.S. .T., Yuen H.F. and Cheung A.N.Y., Effect Of Autophagy On Stemness In Ovarian Clear Cell Carcinoma, Frontiers In Cancer Biology And Drug Development. 2015. |
| Cheung A.N.Y., Guan X. and Ngan H.Y.S., Cervical cancer screening by enhanced cytology: application of novel markers, Hong Kong Med J. 2014. |
| Cheung A.N.Y., Departmental seminar on “The power of eternal youth – stem cell transcription factor Nanog” September 2014. 2014. |
| Cheung A.N.Y., Wong G.W., Chan K.K., Yang M.S., Tsang C.H., Ji S.L., Lo C.K., Szeto E., Wong E.S.Y. and Ngan H.Y.S., Integrated human papillomavirus analysis as an adjunct for triage of atypical cervical cytology, In: ANY Cheung, OG Wong, KKY Chan, MS Yang, CH Tsang, SL Ji, CK Lo, E Szeto, E Wong, HYS Ngan, Hong Kong Med J. 2014. |
| Cheung A.N.Y., Invited plenary speaker on “WHO Classification 2014: Ovarian epithelial tumours” in National Pathology Meeting, Chonqing, China 14-16 Nov 2014. 2014. |
| Cheung A.N.Y., Invited speaker in 2014 International Congress of Pathology & Laboratory Medicine (ICPaLM) and 48th Malaysian-Singapore Congress of Medicine, Kuala Lumpur, Malaysia, 26-28 August 2014, on: 1. Molecular Cytogenetics of Trophoblastic Diseases 2. Endometrial Pathology: An update in Symposium on Gynaecology and Perinatal Pathology and 3. Molecular Cytogenetic in Ovarian Neoplasm in Symposium on Molecular Pathology.. 2014. |
| Cheung A.N.Y., Invited speaker on "Smooth Mucle tumour of Undermined Malignant Potential" in 11th National Obstetrics and Gynaecology Conference, Xiamen, 13th-15th March 2015, 2015. |
| Cheung A.N.Y., Invited speaker on stem cell transcription factor NANOG in gynaecological cancers National University Cancer Research Institute (SNU CRI) Annual Symposium on ‘Innovative Approaches to Explore Novel Druggable Targets’ 1-4th April 2015, Hwasun, Korea.. 2015. |
| Cheung A.N.Y., Invited speaker on “Evolution of pathology tests in cervical cancer screening” in 2015 Conference of Chinese Society for Colposcopy and Cervical Pathology 22th ‐24th May 2015. Beijing. 2015. |
| Cheung A.N.Y., Invited speaker on “Updates on classification of ovarian cancers - Pathology and Genetics”, 5th South China Ovarian Cancer Summit and Focused Meeting on Ovarian Cancer organized by Gynaecology Oncology Subcommittee, Chinese Medical Association, Shenzhen, 29-30th Nov 2014. 2014. |
| Chin W.Y., Johnston J.M., Lam C.L.K. and Cheung A.N.Y., A pilot study to identify quality criteria for community -based medical education in Hong Kong, Asian Journal of Education and e-Learning. 2014. |
| Ho J., DU Y., Wong G.W., Siu K.Y., Chan K.K.L. and Cheung A.N.Y., Downregulation of the Gli Transcription Factors Regulator Kif7 Facilitates Cell Survival and Migration of Choriocarcinoma Cells, PLoS ONE. 2014, 9: e108248. |
| Ip P.C.P., Cheung A.N.Y., Lim D. and Oliva E., Immunoexpression of p16 in uterine leiomyomas with infarct type necrosis, Annual Meeting of The United States and Canadian Academy of Pathology. Nature Publishing, 2015, 28: 291A. |
| JIANG Y., Siu K.Y., Cheung A.N.Y., Ngan H.Y.S. and Chan K.K.L., Pyruvate dehydrogenase kinase 1 (PDHK1) regulates ovarian cancer cell migration, invasion, and chemoresistance and contributes to poor prognosis in patients, EACR-AACR-SIC Special Conference; 20-23 June 2015; Florence, Italy. Abstract no. 152. 2015. |
| Kwok A.L., Wong G.W., Wong E.S.Y., Tsun O.K.L., Chan K.K. and Cheung A.N.Y., Caution over use of ES2 as a model of ovarian clear cell carcinoma., J Clin Pathol . 2014, 67: 921-2. |
| LEUNG T.W., Liu S., Leung C.Y., Chu M.M., Cheung A.N.Y. and Ngan H.Y.S., HPV 16 E2 binding sites 1 and 2 become more methylated than E2 binding site 4 during cervical carcinogenesis., J Med Virol.. 2015, 2015 Jun;87(6):1022-33.. |
| Leung T.W., Liu S., Leung C.Y., Chu M.Y.M., Cheung A.N.Y. and Ngan H.Y.S., HPV 16 E2 binding sites 1 and 2 become more methylated than E2 binding site 4 during cervical carcinogenesis, Journal of Medical Virology. 2015, 87: 1022-1033. |
| Liu S., Chan Y.K., Leung C.Y., Yip M.W., Lau S.K., Liao X.Y., Jiang L.L., Luk M.H.M., Lo S.S., Cheung A.N.Y., Lin Z.Q. and Ngan H.Y.S., Human papillomavirus status in southern Chinese women, Hong Kong Med J. 2014, 2014;20(Suppl 6):S35-8. |
| Mak C.Y., Wong G.W., Siu K.Y., Wong E.S.Y., Ngan W.Y., Wong R.W., Chan K.K., Ngan H.Y.S. and Cheung A.N.Y., FBI-1 Is Overexpressed in Gestational Trophoblastic Disease and Promotes Tumor Growth and Cell Aggressiveness of Choriocarcinoma via PI3K/Akt Signaling., Am J Pathol. 2015, 185(7): 2038-48. |
| Siu K.Y., JIANG Y., Cheung A.N.Y., Ngan H.Y.S. and Chan K.K.L., Overexpression of Hexokinase 2 (HK2) in ovarian cancer contributes to cell migration, invasion and cancer stem-like cells regulation and correlates with poor patient survival., EACR-AACR-SIC Special Conference; 20-23 June 2015; Florence, Italy. Abstract no. 144. 2015. |
| So K.H., Kodithuwakku S.P., Li R.H.W., Chiu C.N., Cheung A.N.Y., Yeung W.S.B. and Lee C.K.F., Embryonic derived hCG down-regulates olfactomedin-1 thrgouh microRNA-212 in tubal ectopic pregnancy. P10, The 31st Annual Scientific Meeting of HKSEMR. 9 Nov 2014, Hong Kong.. 2014. |
| Wong K.W., Ip P.C.P., Tsun O.K.L., Wong E.S.Y., Cheung A.N.Y. and Wong G.W., Potential Targets in miRNA 143 in Cervical cancers, 21st Hong Kong International Cancer Congress. 2014. |
| Zhao F., Siu K.Y., Jiang L.L., Tam K.F., Ngan H.Y.S., Le X.F., Wong G.W., Wong E.S.Y., Gomes A.R., Bella L., Khongkow P., Lam E.W. and Cheung A.N.Y., Overexpression of Forkhead Box Protein M1 (FOXM1) in Ovarian Cancer Correlates with Poor Patient Survival and Contributes to Paclitaxel Resistance, PLoS ONE. 2014, 9: e113478. |
| Researcher : Cheung CH |
| List of Research Outputs |
| Lee K.W., Cheung C.H., Lu P., LAU Y.T., Ma S.K.Y., TANG K.H., Tong M., LO J. and Ng I.O.L., Blockade of CD47 mediated CTSS-PAR2 signaling provides a therapeutic target for hepatocellular carcinoma, Hepatology. 2014, 60: 179-191. |
| Researcher : Cheung YN |
| Project Title: | AACR 101st Annual Meeting eIF4E in human breast cancer and its role in regulating translation of splice variants of breast cancer genes |
| Investigator(s): | Cheung YN |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2010 |
| Researcher : Ching DCK |
| List of Research Outputs |
| Law C.Y., Lam C.W., Ching D.C.K., Yau K.C., Ho T.W., Lai C.K. and Mak C.M., NMR-based urinalysis for beta-ketothiolase deficiency, Clinica Chimica Acta. 2015, 438: 222-225. |
| Researcher : Ching HH |
| List of Research Outputs |
| LO J., Ching H.H., Lau Y.T., CHENG Y.L.B., MA K.F., Lee K.W. and Ng I.O.L., Nuclear Factor Kappa B–mediated Cd47 Up-regulation Promotes Sorafenib Resistance And Its Blockade Synergizes The Effect Of Sorafenib In Hepatocellular Carcinoma In Mice, Hepatology. 2015. |
| Researcher : Ching YP |
| Project Title: | Roles of p21-activated protein kinase (Pak) 1 in the pathogenesis of liver cancer |
| Investigator(s): | Ching YP, Ng IOL, Jin D, Yau TO |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2006 |
| Project Title: | Hepatitis B virus promotes hepatocarcinogenesis by activation of Pak1 |
| Investigator(s): | Ching YP, Jin D |
| Department: | Anatomy |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2010 |
| Completion Date: | 08/2014 |
| Project Title: | HBx oncoprotein induces chromosome instability in hepatocarcinogenesis via dysregulation of centrosome duplication regulatory protein, TAX1BP2 |
| Investigator(s): | Ching YP, Jin D |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2013 |
| Project Title: | The role of centrosomal kinase Nek2 in the pathogenesis of liver cancer |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2013 |
| Completion Date: | 04/2015 |
| Project Title: | Functional characterization of the roles of NIMA-related kinase, Nek2 in liver cancer development and metastasis |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Functional characterization of the roles of NIMA-related kinase, Nek2 in liver cancer development and metastasis |
| Investigator(s): | Ching YP, Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | The therapeutic potential of Polo-like protein kinase 4 in liver cancer |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2015 |
| Project Title: | WIN 2015 Symposium, Novel Targets, Innovative agents, advanced technologies: A Winnning Strategy; The centrosomal protein, TAX1 binding protein 2 (TAX1BP2) regulates the chemo-sensitivity of liver cancer cells |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2015 |
| Researcher : Chiu YT |
| Project Title: | Analysis of hepatitis B virus genomic integration and characterization of its role in hepatocarcinogenesis |
| Investigator(s): | Chiu YT, Ng IOL, Ho DWH |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 10/2013 |
| Project Title: | The significance of X-linked MID1 interacting protein 1 (MID1IP1) in hepatocarcinogenesis |
| Investigator(s): | Chiu YT, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2014 |
| Researcher : Choi WL |
| Project Title: | Correlation of the AML1-ETO isoform transcript levels with the prognosis of patients with acute myeloid leukemia (AML) with t(8;21) |
| Investigator(s): | Choi WL, Chan LC, So JCC, Ha SY, Leung AYH |
| Department: | Pathology |
| Source(s) of Funding: | Queen Mary Hospital Charitable Trust - Training and Research Assistance Scheme |
| Start Date: | 04/2011 |
| List of Research Outputs |
| Chen W.Y.W., Guo T., Shen L., Wong K.Y., Tao Q., Choi W.L., Au Yeung K.H.R., Chan Y.P., Wong M.L.Y., Tang J.C.O., Liu W.P., Li G.D., Shimizu N., Loong F., Tse E.W.C., Kwong Y.L. and Srivastava G., Receptor-type tyrosine-protein phosphatase k directly targets STAT3 activation for tumor suppression in nasal NK/T-cell lymphoma, Blood. United States of America, The American Society of Hematology, 2015, 125(10): 1589-600. |
| Singh G.H.H., Man C.H., Ip H.W., Choi W.L., Chow H.C.H., Kwong Y.L. and Leung A.Y.H., Azacitidine as post-remission consolidation for sorafenib-induced remission of Fms-Like Tyrosine Kinase-3 internal tandem duplication positive acute myeloid leukemia, Haematologica. 2015. |
| Researcher : Chu KY |
| List of Research Outputs |
| Ng I.O.L., Sze M.F. and Chu K.Y., Role of hepatitis B virus X protein in liver cancer, Hong Kong Med J. 2015, 21 Suppl 4: 27-30. |
| Researcher : Chung LP |
| List of Research Outputs |
| So J.C.C., Chan A., Chung L.P., Siu L., Wong W.S. and Wong K.F., A comparison of high resolution melting, allele-specific priming and Sanger sequencing for the detection of BRAFV600E mutation in hairy cell leukaemia from different haematological specimens, Pathology. 2014, 46: 533-537. |
| Researcher : DU Y |
| List of Research Outputs |
| Ho J., DU Y., Wong G.W., Siu K.Y., Chan K.K.L. and Cheung A.N.Y., Downregulation of the Gli Transcription Factors Regulator Kif7 Facilitates Cell Survival and Migration of Choriocarcinoma Cells, PLoS ONE. 2014, 9: e108248. |
| Researcher : Deng J |
| List of Research Outputs |
| Zhang X., Shen J., Man K., Chu E.S., Yau T.O., Sung J.C., Go M.Y., Deng J., Lu L., Wong V.W., Sung J.J., Farrell G. and Yu J., CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis, Journal of Hepatology. 2014, Epub on 2014-07-15. |
| Researcher : Fan NY |
| List of Research Outputs |
| Tsang F.H., Au L.K.S., Fan N.Y., Lee M.F., Wong C.C.L., Ng I.O.L. and Wong C.M., HOTTIP, an oncogenic long non-coding RNA, is frequently up-regulated in hepatocellular carcinoma and is negatively regulated by tumor suppressive microRNA miR-125b, Liver International. 2015, 35: 1597. |
| Wong C.C.L., Au L.K.S., Tse P.W., Xu M., LAI K.H., CHIU K.C., WEI L., Fan N.Y., Tsang F.H., Lo C.L.R., Wong C.M. and Ng I.O.L., Switching of pyruvate kinase isoform L to M2 promotes metabolic reprogramming in hepatocarcinogenesis, PLos One. 2014. |
| Wong C.M., WEI L., Au L.K.S., Fan N.Y., Zhou Y., Tsang F.H., Lee M.F., He X., Shi J., Wong C.C.L. and Ng I.O.L., miR-200b/200c/429 subfamily negatively regulates Rho/ROCK signaling pathway and suppresses HCC metastasis, Oncotarget . 2015, 6: 13658. |
| Researcher : GAO X |
| List of Research Outputs |
| GAO X., Lin C., Kwan T.K., Lee V.H.F., Chan S.H., Sihoe D.L.A., Au S.K., Tin P.C., XIAO Z., Yam J.W.P., Wang J.J., Sham P.C. and Wong M.P., Application of whole exome sequencing in metachronous lung cancers evaluation, European Association for Cancer Research, Cambridge. 2015. |
| Researcher : Gong C |
| List of Research Outputs |
| Gong C., Fujino K., Monteiro L.J., Gomes A.R., Drost R., Davidson-Smith H., Takeda S., Khoo U.S., Jonkers J., Sproul D. and Lam E.W., FOXA1 repression is associated with loss of BRCA1 and increased promoter methylation and chromatin silencing in breast cancer, Oncogene. 2014. |
| Khongkow P., Karunarathna U., Khongkow M., Gong C., Gomes A.R., Yague E., Monteiro L.J., Kongsema M., Zona S., Man P.S., Tsang J.W.H., Coombes R.C., Wu K.J., Khoo U.S., Medema R.H., Freire R. and Lam E.W., FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance, Oncogene. 2014, 33(32): 4144-55. |
| Khongkow P., Gomes A.R., Gong C., Man P.S., Tsang J.W.H., Zhao F., Monteiro L.J., Coombes R.C., Medema R.H., Khoo U.S. and Lam E.W., Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast cancer paclitaxel resistance, Oncogene. 2015. |
| Researcher : Ho DWH |
| Project Title: | Integrative investigation of somatic copy number and gene expression alterations in human hepatocellular carcinoma |
| Investigator(s): | Ho DWH, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2014 |
| Completion Date: | 06/2015 |
| List of Research Outputs |
| Bai X., Ho D.W.H., Fung K., Tang L., He M., Young D., Ho F. and Kwok T., Effectiveness of a Life Story Work program on Older Adults with Intellectual Disabilities, Clinical Interventions in Aging. 2014. |
| Ho D.W.H., Mak V., Kwok T., Au A. and Ho F., Development of a Web-Based Training Program for Dementia Caregivers in Hong Kong, Clinical Gerontologist. 2015, 38: 211-223. |
| Ho D.W.H. and Ng I.O.L., uGPA: unified Gene Pathway Analyzer package for high-throughput genome-wide screening data provides mechanistic overview on human diseases, Clinica Chimica Acta. 2015, 441: 105-108. |
| Ma W., Ho D.W.H. and Ng I.O.L., Overexpression of APOBEC3B enhances invasiveness of hepatocellular carcinoma, AACR annual meeting 2015. |
| Researcher : Ho RSL |
| List of Research Outputs |
| Leung W.K., Tong D.K.H., Leung S.Y., Chan S.Y., Tong S.M., Ho R.S.L., Chu K.M. and Law S.Y.K., Treatment of gastric metaplasia or dysplasia by endoscopic radiofrequency ablation: A pilot study, Hepato-Gastroenterology. 2015, 62: 52-55. |
| Researcher : Huang F |
| Project Title: | Generation of dendritic cells from liver cancer cell-derived iPSc for novel tumor vaccine development - Part I: Reprogramming of liver cancer cells to pluripotency using non-viral plasmid vectors |
| Investigator(s): | Huang F |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 10/2014 |
| List of Research Outputs |
| Huang F., Associate Editor (since Jan 2015), In: Catherine Sautes-Fridman , Frontiers in Immunology. Switzerland, [Lausanne : Frontiers Research Foundation], 2015. |
| Huang F., Autoimmuno-Anti-Tumor Immunity (AATI) - Understanding the Immune Responses against "self" and "Altered-Self", In: Wolf Hervé Fridman, Frontiers in Immunology. Switzerland, [Lausanne : Frontiers Research Foundation], 2014, 5: 1-2. |
| Huang F., Science Editor (since July 2014), Asian Council of Science Editors. Asian Council of Science Editors, 2014. |
| Huang F., Section Editor (since Feb 2015), SM Vaccines and Vaccination Journal. Dover, USA, 2015. |
| Zhao H.Z., Davies T.J., Ning J., Chang Y., Sachamitr P., Sattler S., Fairchild P.J. and Huang F., A Highly Optimized Protocol for Reprogramming Cancer Cells to Pluripotency Using Nonviral Plasmid Vectors, In: Professor Sir Ian Wilmut, OBE FRS FRSE Dr. Jane Taylor, Cellular Reprogramming. USA, Mary Ann Liebert, Inc., 2015, 17: 7-18. |
| Researcher : Ip HW |
| List of Research Outputs |
| Ip H.W., So J.C.C., Leung R.Y.Y., Chan J.Y., Sin P. and Lam C.C.K., Acquired factor VIII inhibitor and positive lupus anticoagulant testing on silica clotting time, International Journal of Laboratory Hematology. 2015, 37: 139-141. |
| Ip H.W. and So J.C.C., Deep molecular response in chronic myelogenous leukemia: ensuring accuracy and consistency, Leukemia. 2015. |
| Singh G.H.H., Man C.H., Ip H.W., Choi W.L., Chow H.C.H., Kwong Y.L. and Leung A.Y.H., Azacitidine as post-remission consolidation for sorafenib-induced remission of Fms-Like Tyrosine Kinase-3 internal tandem duplication positive acute myeloid leukemia, Haematologica. 2015. |
| Singh G.H.H., Ip H.W., Pang A.W.K., Sum C.Y., Leung A.Y.H. and Kwong Y.L., FLT3 internal tandem duplication in acute promyelocytic leukemia: central nervous system relapse, Annals of Hematology. 2014. |
| Researcher : Ip PCP |
| Project Title: | Annual Meeting: United States and Canadian Academy of Pathology; Immunoexpression of p16 in uterine leiomyomas with infarct type necrosis |
| Investigator(s): | Ip PCP |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2015 |
| Completion Date: | 03/2015 |
| Project Title: | CELLULAR FUNCTIONS AND CLINICAL APPLICATION OF MICRO-RNA IN OVARIAN CARCINOMAS |
| Investigator(s): | Ip PCP, Cheung ANY, Wong GW, Ngan HYS, Tse KY |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2015 |
| List of Research Outputs |
| Ip P.C.P., 2014 WHO Classification of Tumours of Female Reproductive Organs: Summary of Changes Relevant to our Daily Practice, 21st Hong Kong International Cancer Congress. 2014. |
| Ip P.C.P., Cheung A.N.Y., Lim D. and Oliva E., Immunoexpression of p16 in uterine leiomyomas with infarct type necrosis, Annual Meeting of The United States and Canadian Academy of Pathology. Nature Publishing, 2015, 28: 291A. |
| Lai C.L., Wong D.K.H., Ip P.C.P., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lee B.P., Cullaro G., Wu C.H., Cheng C.T.K., Yuen J.C.H., Ngai W.S. and Yuen R.M.F., Profound Reduction of HBV Covalently Closed Circular DNA with Long-term Nucleoside/tide Analogue Therapy, Hepatology. 2014, 60, No. 4 (Suppl): 183A. |
| Tsang C.L., Chan J.F.W., Ip P.C.P., Ngan A.H.Y., Chen J.H.K., Lau S.K.P. and Woo P.C.Y., Subcutaneous Phaeohyphomycotic Nodule Due to Phialemoniopsis hongkongensis sp. nov., In: Alexander J. McAdam, MD, Journal of Clinical Microbiology. American Society for Microbiology (ASM), 2014, 52: 3280-3289. |
| Wong K.W., Ip P.C.P., Tsun O.K.L., Wong E.S.Y., Cheung A.N.Y. and Wong G.W., Potential Targets in miRNA 143 in Cervical cancers, 21st Hong Kong International Cancer Congress. 2014. |
| Researcher : Ip PPC |
| Project Title: | Annual Meeting: United States and Canadian Academy of Pathology; Immunoexpression of p16 in uterine leiomyomas with infarct type necrosis |
| Investigator(s): | Ip PCP |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2015 |
| Completion Date: | 03/2015 |
| Project Title: | CELLULAR FUNCTIONS AND CLINICAL APPLICATION OF MICRO-RNA IN OVARIAN CARCINOMAS |
| Investigator(s): | Ip PCP, Cheung ANY, Wong GW, Ngan HYS, Tse KY |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2015 |
| List of Research Outputs |
| Researcher : Kai AKL |
| Project Title: | The roles of chemokine C-C motif ligand 28 (CCL28) in hepatocarcinogenesis |
| Investigator(s): | Kai AKL, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2014 |
| Project Title: | American association of cancer research annual meeting 2014; Hypoxia-inducible HIF1α-miR-210 signaling axis enhances chemoresistance in human hepatocellular carcinoma |
| Investigator(s): | Kai AKL |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2014 |
| List of Research Outputs |
| Leung O.N., Wong C.C.L., Fan D.N., Kai A.K.L., Tung E.K., Xu M., Ng I.O.L. and Lo C.L.R., PIM1 regulates glycolysis and promotes tumor progression in hepatocellular carcinoma., Oncotarget. 2015. |
| Lo C.L.R., Leung O.N., Wong C.C.L., Kai A.K.L. and Ng I.O.L., Pim1 Is Upregulated By Hypoxia In Hepatocellular Carcinoma And Promotes Tumor Progression , International Liver Cancer Association Annual Conference 2014. |
| Wong C.C.L., Tse P.W., Huang Y., Zhu Y., CHIU K.C., LAI K.H., Au L.K.S., Kai A.K.L., Lee M.F., WEI L., Tsang F.H., Lo C.L.R., Shi J., Zheng Y., Wong C.M. and Ng I.O.L., Lysyl Oxidase-like 2 Is Critical To Tumor Microenvironment And Metastatic Niche Formation In Hepatocellular Carcinoma, In: Snorry Thorgeirsen, Hepatology. 2014. |
| Researcher : Kan NCA |
| List of Research Outputs |
| Chong Y.K., Ma L.C., Lo K.L., Lee C.K., Mak C.M., Kan N.C.A. and Lam C.W., Dystroglycanopathy with two novel POMT1 mutations in a Chinese boy with developmental delay and muscular dystrophy, In: Chong YK, Ma LC, Lo KL, Lee CK, Mak CM, Kan AN, Lam CW, European Journal of Paediatric Neurology. 2014, 18: 532-535. |
| Researcher : Khoo US |
| Project Title: | Association of the pro-inflammatory and anti-inflammatory cytokine gene polymorphism to breast cancer susceptibility |
| Investigator(s): | Khoo US, Cheung ANY, Chan YK |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Project Title: | Infectious Diseases and Global Health: Genetic approach to the identification of host susceptibility factors and pathogen virulence determinants. Genetics of coronaviruses-associated acute respiratory disease |
| Investigator(s): | Khoo US |
| Department: | Pathology |
| Source(s) of Funding: | CGDN NCE Large Scale Collaborative Research Grant |
| Start Date: | 02/2005 |
| Project Title: | HER2 FISH test to assess eligibility for transtuzumab (herceptin) in breast cancer patients applying for assistance from Samaritan Fund for treatment |
| Investigator(s): | Khoo US, Au GKH, Leung TW, Luk MY, Yau TK |
| Department: | Pathology |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 07/2010 |
| Project Title: | Role of eIF4E in tamoxifen resistance in breast cancer |
| Investigator(s): | Khoo US |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2013 |
| Project Title: | HER2 Dual ISH test to assess eligibility for Trastuzumab (Herceptin) in breast cancer patients receiving treatment from public hospitals |
| Investigator(s): | Khoo US, Leung TW, Luk MY, Yeung MWR |
| Department: | Pathology |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 11/2013 |
| Project Title: | Development of Antibody Specific to Splice Variant of NCOR2 for the Management of Breast Cancer |
| Investigator(s): | Khoo US, Lee KW, Tsang JWH, Man PS |
| Department: | Pathology |
| Source(s) of Funding: | Innovation and Technology Support Programme (Tier 3) |
| Start Date: | 12/2013 |
| Completion Date: | 05/2015 |
| Project Title: | Development of Antibody Specific to Splice Variant of NCOR2 for the Management of Breast Cancer |
| Investigator(s): | Khoo US, Lee KW, Tsang JWH, Man PS |
| Department: | Pathology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 01/2014 |
| Completion Date: | 05/2015 |
| Project Title: | Development of Antibody Specific to Splice Variant of NCOR2 for the Management of Breast Cancer |
| Investigator(s): | Khoo US, Lee KW, Tsang JWH, Man PS |
| Department: | Pathology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 01/2014 |
| Completion Date: | 05/2015 |
| Project Title: | Development of a method for ex vivo expansion of in vivo captured circulating tumor cells from breast cancer patients for molecular profiling. |
| Investigator(s): | Khoo US, Tsang JWH, Tang MKP |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 06/2014 |
| Project Title: | 30th International Congress of the International Academy of Pathology (IAP 2014); Innovative use of technologies to enhance the teaching of Pathology. |
| Investigator(s): | Khoo US |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2014 |
| Completion Date: | 10/2014 |
| Project Title: | The regulatory effect of a novel splice variant, BQ323636.1, on ERα transcriptional activity facilitates the development of tamoxifen resistance in breast cancer |
| Investigator(s): | Khoo US, Tang MKP |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2015 |
| List of Research Outputs |
| Cai Q., Zhang B., Sung H., Low S.K., Kweon S.S., Lu W., Shi J., Long J., Wen W., Choi J.Y., Noh D.Y., Shen C.Y., Matsuo K., Teo S.H., Kim M.K., Khoo U.S., Iwasaki M., Hartman M., Takahashi A., Ashikawa K., Matsuda K., Shin M.H., Park M.H., Zheng Y., Xiang Y.B., Ji B.T., Park S.K., Wu P.E., Hsiung C.N., Ito H., Kasuga Y., Kang P., Mariapun S., Ahn S.H., Kang H.S., Chan Y.K., Man P.S., Iwata H., Tsugane S., Miao H., Liao J., Nakamura Y., Kubo M., Consortium D.G., Delahanty R.J., Zhang Y., Li B., Li C., Gao Y.T., Shu X.O., Kang D. and Zheng W., Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1, Nat Genet. 2014, 46(8): 886-90. |
| Gong C., Fujino K., Monteiro L.J., Gomes A.R., Drost R., Davidson-Smith H., Takeda S., Khoo U.S., Jonkers J., Sproul D. and Lam E.W., FOXA1 repression is associated with loss of BRCA1 and increased promoter methylation and chromatin silencing in breast cancer, Oncogene. 2014. |
| Khongkow P., Karunarathna U., Khongkow M., Gong C., Gomes A.R., Yague E., Monteiro L.J., Kongsema M., Zona S., Man P.S., Tsang J.W.H., Coombes R.C., Wu K.J., Khoo U.S., Medema R.H., Freire R. and Lam E.W., FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance, Oncogene. 2014, 33(32): 4144-55. |
| Khongkow P., Gomes A.R., Gong C., Man P.S., Tsang J.W.H., Zhao F., Monteiro L.J., Coombes R.C., Medema R.H., Khoo U.S. and Lam E.W., Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast cancer paclitaxel resistance, Oncogene. 2015. |
| Khoo U.S., Innovative Use of Technologies in Teaching of Pathology., Hong Kong Pathology Forum 2015. 2015. |
| Khoo U.S., Innovative Use of Technologies in Teaching of Pathology, Hong Kong Pathology Forum 2015. |
| Khoo U.S., Innovative Use of Technologies to Enhance the Teaching of Pathology., Symposium: Teaching and Examinations in Pathology, International Academy of Pathology, Bangkok. 2014. |
| Khoo U.S., Pathology Education: Innovative use of Technologies to Enhance the Teaching of Pathology., 30th International Congress of the International Academy of Pathology, Bangkok, Thailand. 2014. |
| Khoo U.S. and Knutzen K.B., Pilot Study of a Virtual 3D Laboratory for Simulated Training on Laboratory Safety Measures, Showcase presentation at HERDSA 2014 Conference in Hong Kong. 2014. |
| Researcher : Ko FCF |
| Project Title: | Unravel the RhoGAP independent pathway of Deleted in Liver Cancer 1 tumor suppressor |
| Investigator(s): | Ko FCF, Yam JWP |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2012 |
| Project Title: | The study of DLC1 regulates oxidative stress for tumor suppression |
| Investigator(s): | Ko FCF, Yam JWP |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2014 |
| List of Research Outputs |
| Mao X., WONG Y.S.S., Ko F.C.F. and Yam J.W.P., Upregulation of S100P by caveolin-1 drives tumorigenesis and metastasis in hepatocellular carcinoma under hypoxic stress, 2015 American Association for Cancer Research Annual Meeting. 2015. |
| TEY S.K., TSE Y.T., Ko F.C.F. and Yam J.W.P., Overexpression of nuclear met activates NF-KB signaling to promote tumorigenesis and metastasis in hepatocellullar carcinoma, 2015 American Association for Cancer Research Annual Meeting. 2015. |
| Researcher : Ko KH |
| List of Research Outputs |
| Lin X., Tian J., Rui K., Ma K., Ko K.H., Wang S. and Lu L., The role of T helper 17 cell subsets in Sjogren's syndrome: similarities and differences between mouse model and humans, Annals of the Rheumatic Diseases. 2014, 73: e43-e43. |
| Researcher : Kwan TK |
| List of Research Outputs |
| GAO X., Lin C., Kwan T.K., Lee V.H.F., Chan S.H., Sihoe D.L.A., Au S.K., Tin P.C., XIAO Z., Yam J.W.P., Wang J.J., Sham P.C. and Wong M.P., Application of whole exome sequencing in metachronous lung cancers evaluation, European Association for Cancer Research, Cambridge. 2015. |
| Wong M.P., Liu J., XIAO Z., Tin P.C., Wang S. and Kwan T.K., Calcium/calmodulin-dependent protein kinase II alpha (CaMK2A) regulates the tumor initiating cell phenotype through SOX2 expression and modulates treatment response to anti-cancer drugs in lung adenocarcinoma. , Annual Scientific Meeting of the American Association for Cancer Research, Philadelphia. 2015. |
| Researcher : Kwong HY |
| List of Research Outputs |
| Chan M.C.W., Kwong H.Y. and Nicholls J.M., Susceptibility of the Upper Respiratory Tract to Influenza Virus Infection Following Desialyation (Abstract & poster presentation), Health Research Symposium 2014, 15 November 2014, Hong Kong. 2014, P132-Ab0100. |
| Researcher : LAI KH |
| List of Research Outputs |
| Wong C.C.L., Tse P.W., Huang Y., Zhu Y., CHIU K.C., LAI K.H., Au L.K.S., Kai A.K.L., Lee M.F., WEI L., Tsang F.H., Lo C.L.R., Shi J., Zheng Y., Wong C.M. and Ng I.O.L., Lysyl Oxidase-like 2 Is Critical To Tumor Microenvironment And Metastatic Niche Formation In Hepatocellular Carcinoma, In: Snorry Thorgeirsen, Hepatology. 2014. |
| Wong C.C.L., Au L.K.S., Tse P.W., Xu M., LAI K.H., CHIU K.C., WEI L., Fan N.Y., Tsang F.H., Lo C.L.R., Wong C.M. and Ng I.O.L., Switching of pyruvate kinase isoform L to M2 promotes metabolic reprogramming in hepatocarcinogenesis, PLos One. 2014. |
| Researcher : LAU YT |
| List of Research Outputs |
| LO J., Ching H.H., Lau Y.T., CHENG Y.L.B., MA K.F., Lee K.W. and Ng I.O.L., Nuclear Factor Kappa B–mediated Cd47 Up-regulation Promotes Sorafenib Resistance And Its Blockade Synergizes The Effect Of Sorafenib In Hepatocellular Carcinoma In Mice, Hepatology. 2015. |
| Lee K.W., Cheung C.H., Lu P., LAU Y.T., Ma S.K.Y., TANG K.H., Tong M., LO J. and Ng I.O.L., Blockade of CD47 mediated CTSS-PAR2 signaling provides a therapeutic target for hepatocellular carcinoma, Hepatology. 2014, 60: 179-191. |
| Liu J., Lau Y.T., Chen J., Yong J., Tang K.D., Lo J., Ng I.O.L., Lee K.W. and Ling M.T., Polysaccharopeptide enhanced the anti-cancer effect of gamma-tocotrienol through activation of AMPK, BMC Complement Altern Med. 2014, 14: 303. |
| Researcher : LEE D |
| List of Research Outputs |
| LEE D., Sun S., ZHANG X., Zhang P., KIANG M.Y. and Leung G.K.K., MicroRNA-210 and endoplasmic reticulum chaperones in the regulation of chemoresistance in glioblastoma, Journal of Cancer. 2015, 6: 227-232. |
| Researcher : LO J |
| List of Research Outputs |
| LO J., Ching H.H., Lau Y.T., CHENG Y.L.B., MA K.F., Lee K.W. and Ng I.O.L., Nuclear Factor Kappa B–mediated Cd47 Up-regulation Promotes Sorafenib Resistance And Its Blockade Synergizes The Effect Of Sorafenib In Hepatocellular Carcinoma In Mice, Hepatology. 2015. |
| Lee K.W., Cheung C.H., Lu P., LAU Y.T., Ma S.K.Y., TANG K.H., Tong M., LO J. and Ng I.O.L., Blockade of CD47 mediated CTSS-PAR2 signaling provides a therapeutic target for hepatocellular carcinoma, Hepatology. 2014, 60: 179-191. |
| Liu J., Lau Y.T., Chen J., Yong J., Tang K.D., Lo J., Ng I.O.L., Lee K.W. and Ling M.T., Polysaccharopeptide enhanced the anti-cancer effect of gamma-tocotrienol through activation of AMPK, BMC Complement Altern Med. 2014, 14: 303. |
| Researcher : Lai JCC |
| Project Title: | Comparison of native influenza virus and virus-like-particles in their receptor-binding properties |
| Investigator(s): | Lai JCC, Nicholls JM |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2014 |
| Researcher : Lam AKY |
| List of Research Outputs |
| XU W., Li B., Lam A.K.Y., Tsao G.S.W., Law S.Y.K., Chan K.W., Yuan Q. and Cheung A., Targeting VEGFR-1 and VEGFR2-expressing non-tumor cells is essential for esophageal cancer therapy, Oncotarget. 2014, 6(3): 1790-1805. |
| Researcher : Lam CCK |
| List of Research Outputs |
| Ip H.W., So J.C.C., Leung R.Y.Y., Chan J.Y., Sin P. and Lam C.C.K., Acquired factor VIII inhibitor and positive lupus anticoagulant testing on silica clotting time, International Journal of Laboratory Hematology. 2015, 37: 139-141. |
| Researcher : Lam CW |
| Project Title: | Whole genome scan of genetic susceptibility for hepatitis B carries |
| Investigator(s): | Lam CW |
| Department: | Pathology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 04/2006 |
| Completion Date: | 08/2014 |
| Project Title: | The first prospective second generation newborn screening in Hong Kong |
| Investigator(s): | Lam CW, Chan AYW, Mak CM |
| Department: | Pathology |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 10/2012 |
| Project Title: | Food |
| Investigator(s): | Lam CW, Wang M |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 09/2013 |
| Project Title: | Undiagnosed diseases program for ending diagnostic odyssey |
| Investigator(s): | Lam CW |
| Department: | Pathology |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 11/2014 |
| List of Research Outputs |
| Cheung C.Y., Tam S., Lam C.W., Lie A.K.W. and Kwong Y.L., Allogeneic haematopoietic stem cell transplantation for erythropoietic protoporphyria: A cautionary note, Blood Cells, Molecules, and Diseases. 2015, 54: 266-267. |
| Chong Y.K., Ma L.C., Lo K.L., Lee C.K., Mak C.M., Kan N.C.A. and Lam C.W., Dystroglycanopathy with two novel POMT1 mutations in a Chinese boy with developmental delay and muscular dystrophy, In: Chong YK, Ma LC, Lo KL, Lee CK, Mak CM, Kan AN, Lam CW, European Journal of Paediatric Neurology. 2014, 18: 532-535. |
| Harris I.S., Treloar A.E., Inoue S., Sasaki M., Gorrini C., Lee K.C., Yung K.Y., Brenner D., Knobbe-Thomsen C.B., Cox M.A., Elia A., Berger T., Cescon D.W., Adeoye A., Brüstle A., Molyneux S.D., Mason J.M., Li W.Y., Yamamoto K., Wakeham A., Berman H.K., Khokha R., Done S.J., Kavanagh T.J., Lam C.W. and Mak T.W., Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression, Cancer Cell. 2015, 27: 211-222. |
| Lam C.W. and Law C.Y., Advanced Laboratory Medicine using Clinical Metabonomics for Biomarker Discovery of Malignant Pleural Effusions (MPE), In: Ching-wan Lam, Chun-yiu Law, Pathology Update 2015 conference (Melbourne), Royal College of Pathologists in Australasia, in February 2015. |
| Lam C.W., NMR method for detecting urine metabolomics, In: Prof Lam Ching Wan, The First Asian Symposium on AADC Deficiency (2014/12/21) 臺大醫院基因醫學部. 2014. |
| Lam C.W., Law C.Y., Leung K.F., Lai C.K., Chen S.P.L., Chan B., Chan K.Y., Yuen L.Y.P., Mak C.M. and Chan A.Y.W., NMR-based urinalysis for rapid diagnosis of β-ureidopropionase deficiency in a patient with Dravet syndrome, Clinica Chimica Acta. 2015, 440: 201-204. |
| Lam C.W. and Law C.Y., Pleural Effusion Lipoproteins Measured by NMR Spectroscopy for Diagnosis of Exudative Pleural Effusions: A Novel Tool for Pore-Size Estimation, In: Lam CW, Law CY, Journal of Proteome Research. 2014, 13: 4104-4112. |
| Lam C.W., Law C.Y., Sze K.H. and To K.K.W., Quantitative metabolomics of urine for rapid etiological diagnosis of urinary tract infection: Evaluation of a microbial-mammalian co-metabolite as a diagnostic biomarker., Clinica chimica acta. 2014, 438C: 24-28. |
| Lam C.W. and Law C.Y., Untargeted Mass Spectrometry-Based Metabolomic Profiling of Pleural Effusions: Fatty Acids as Novel Cancer Biomarkers for Malignant Pleural Effusions, In: Lam CW, Law CY, Journal of Proteome Research. 2014, 13: 4040-4046. |
| Lam C.W. and Law C.Y., Winner of Roche Scientific Display, Chemical Pathology (Co-author) in Pathology Update 2015 (Melbourne)., The Royal College of Pathologists in Australasia (RCPA). . 2015. |
| Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Lau C.Y., Chow W.N., Ngan A.H., To K.K.W., Chan J.F.W., Hung I.F.N., Yam W.C., Yuen K.Y. and Woo P.C.Y., Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics: exploration of potential biomarkers, Emerging Microbes & Infections. 2015, 4: e6. |
| Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Lau C.Y., Chow W.N., Ngan A.H., To K.K.W., Chan J.F.W., Hung I.F.N., Yam W.C., Yuen K.Y. and Woo P.C.Y., Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics: exploration of potential biomarkers, Emerging Microbes and Infections. 2015, 4: e6. |
| Lau S.K.P., Sridhar S., Ho C.C., Chow W.N., Lee K.C., Lam C.W., Yuen K.Y. and Woo P.C.Y., Laboratory diagnosis of melioidosis: Past, present and future, Experimental Biology and Medicine. 2015, 240: 742-751. |
| Law C.Y. and Lam C.W., Board of Education and Assessment Poster Prize (runner up) in Pathology Update 2015 (Melbourne)., The Royal College of Pathologists of Australasia (RCPA).. 2015. |
| Law C.Y. and Lam C.W., NMR-based Urinalysis for Rapid Diagnosis of Inborn Errors of Metabolism, In: Chun-yiu Law, Ching-wan Lam, Pathology Update 2015 conference (Melbourne), Royal College of Pathologists in Australasia, in February 2015. |
| Law C.Y., Lam C.W., Ching D.C.K., Yau K.C., Ho T.W., Lai C.K. and Mak C.M., NMR-based urinalysis for beta-ketothiolase deficiency, Clinica Chimica Acta. 2015, 438: 222-225. |
| Law C.Y. and Lam C.W., New Lights in Light’s Criteria, In: Chun-yiu Law, Ching-wan Lam , Pathology Update 2015 conference (Melbourne), Royal College of Pathologists in Australasia, in February 2015. |
| Lee K.C., Tam W.T., Lo K.C., Tsang K.L., Lau C.Y., To K.K.W., Chan J.F.W., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Metabolomics Analysis Reveals Specific Novel Tetrapeptide and Potential Anti-Inflammatory Metabolites in Pathogenic Aspergillus species, International Journal of Molecular Sciences. 2015, 16: 13850-13867. |
| To K.K.W., Lee K.C., Wong S.S.Y., Lo K.C., Lui Y.M., Akhee S.J., Wu L., Ke Y., Law C.Y., Sze K.H., Lau S.K.P., Woo P.C.Y., Lam C.W. and Yuen K.Y., Lipid mediators of inflammation as novel plasma biomarkers to identify patients with bacteremia, Journal of Infection. 2015, 70: 433-444. |
| Woo P.C.Y., Lam C.W., Tam W.T., Lee K.C., Yung K.Y., Leung K.F., Sze K.H., Lau S.K.P. and Yuen K.Y., The biosynthetic pathway for a thousand-year-old natural food colorant and citrinin in Penicillium marneffei, Scientific Reports. 2014, 4: 6728. |
| Researcher : Lau YT |
| Project Title: | American Association for Cancer Research Annual Meeting; Cancer-associated fibroblast-derived HGF regulates cancer stem cell-like properties in hepatocellular carcinoma through c-Met/FRA1/HEY1 signaling pathway |
| Investigator(s): | Lau YT |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2015 |
| List of Research Outputs |
| LO J., Ching H.H., Lau Y.T., CHENG Y.L.B., MA K.F., Lee K.W. and Ng I.O.L., Nuclear Factor Kappa B–mediated Cd47 Up-regulation Promotes Sorafenib Resistance And Its Blockade Synergizes The Effect Of Sorafenib In Hepatocellular Carcinoma In Mice, Hepatology. 2015. |
| Lee K.W., Cheung C.H., Lu P., LAU Y.T., Ma S.K.Y., TANG K.H., Tong M., LO J. and Ng I.O.L., Blockade of CD47 mediated CTSS-PAR2 signaling provides a therapeutic target for hepatocellular carcinoma, Hepatology. 2014, 60: 179-191. |
| Liu J., Lau Y.T., Chen J., Yong J., Tang K.D., Lo J., Ng I.O.L., Lee K.W. and Ling M.T., Polysaccharopeptide enhanced the anti-cancer effect of gamma-tocotrienol through activation of AMPK, BMC Complement Altern Med. 2014, 14: 303. |
| Researcher : Law CY |
| Project Title: | Pathology Update 2015; NMR-based Urinalysis for Rapid Diagnosis of Inborn Errors of Metabolism |
| Investigator(s): | Law CY |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 02/2015 |
| Completion Date: | 03/2015 |
| List of Research Outputs |
| Lam C.W. and Law C.Y., Advanced Laboratory Medicine using Clinical Metabonomics for Biomarker Discovery of Malignant Pleural Effusions (MPE), In: Ching-wan Lam, Chun-yiu Law, Pathology Update 2015 conference (Melbourne), Royal College of Pathologists in Australasia, in February 2015. |
| Lam C.W., Law C.Y., Leung K.F., Lai C.K., Chen S.P.L., Chan B., Chan K.Y., Yuen L.Y.P., Mak C.M. and Chan A.Y.W., NMR-based urinalysis for rapid diagnosis of β-ureidopropionase deficiency in a patient with Dravet syndrome, Clinica Chimica Acta. 2015, 440: 201-204. |
| Lam C.W. and Law C.Y., Pleural Effusion Lipoproteins Measured by NMR Spectroscopy for Diagnosis of Exudative Pleural Effusions: A Novel Tool for Pore-Size Estimation, In: Lam CW, Law CY, Journal of Proteome Research. 2014, 13: 4104-4112. |
| Lam C.W., Law C.Y., Sze K.H. and To K.K.W., Quantitative metabolomics of urine for rapid etiological diagnosis of urinary tract infection: Evaluation of a microbial-mammalian co-metabolite as a diagnostic biomarker., Clinica chimica acta. 2014, 438C: 24-28. |
| Lam C.W. and Law C.Y., Untargeted Mass Spectrometry-Based Metabolomic Profiling of Pleural Effusions: Fatty Acids as Novel Cancer Biomarkers for Malignant Pleural Effusions, In: Lam CW, Law CY, Journal of Proteome Research. 2014, 13: 4040-4046. |
| Lam C.W. and Law C.Y., Winner of Roche Scientific Display, Chemical Pathology (Co-author) in Pathology Update 2015 (Melbourne)., The Royal College of Pathologists in Australasia (RCPA). . 2015. |
| Law C.Y. and Lam C.W., Board of Education and Assessment Poster Prize (runner up) in Pathology Update 2015 (Melbourne)., The Royal College of Pathologists of Australasia (RCPA).. 2015. |
| Law C.Y. and Lam C.W., NMR-based Urinalysis for Rapid Diagnosis of Inborn Errors of Metabolism, In: Chun-yiu Law, Ching-wan Lam, Pathology Update 2015 conference (Melbourne), Royal College of Pathologists in Australasia, in February 2015. |
| Law C.Y., Lam C.W., Ching D.C.K., Yau K.C., Ho T.W., Lai C.K. and Mak C.M., NMR-based urinalysis for beta-ketothiolase deficiency, Clinica Chimica Acta. 2015, 438: 222-225. |
| Law C.Y. and Lam C.W., New Lights in Light’s Criteria, In: Chun-yiu Law, Ching-wan Lam , Pathology Update 2015 conference (Melbourne), Royal College of Pathologists in Australasia, in February 2015. |
| Lee H.H.C., Law C.Y., Chen M.L., Lam Y.H., Chan A.Y. and Mak T.W., 2,4-Dinitrophenol: A threat to Chinese body-conscious groups, In: Lee HC, Law CY, Chen ML, Lam YH, Chan AY, Mak TW, J Chin Med Assoc. 2014. |
| To K.K.W., Lee K.C., Wong S.S.Y., Lo K.C., Lui Y.M., Akhee S.J., Wu L., Ke Y., Law C.Y., Sze K.H., Lau S.K.P., Woo P.C.Y., Lam C.W. and Yuen K.Y., Lipid mediators of inflammation as novel plasma biomarkers to identify patients with bacteremia, Journal of Infection. 2015, 70: 433-444. |
| Researcher : Lee HHC |
| List of Research Outputs |
| Lee H.H.C., Law C.Y., Chen M.L., Lam Y.H., Chan A.Y. and Mak T.W., 2,4-Dinitrophenol: A threat to Chinese body-conscious groups, In: Lee HC, Law CY, Chen ML, Lam YH, Chan AY, Mak TW, J Chin Med Assoc. 2014. |
| Researcher : Lee KC |
| List of Research Outputs |
| Harris I.S., Treloar A.E., Inoue S., Sasaki M., Gorrini C., Lee K.C., Yung K.Y., Brenner D., Knobbe-Thomsen C.B., Cox M.A., Elia A., Berger T., Cescon D.W., Adeoye A., Brüstle A., Molyneux S.D., Mason J.M., Li W.Y., Yamamoto K., Wakeham A., Berman H.K., Khokha R., Done S.J., Kavanagh T.J., Lam C.W. and Mak T.W., Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression, Cancer Cell. 2015, 27: 211-222. |
| Woo P.C.Y., Lam C.W., Tam W.T., Lee K.C., Yung K.Y., Leung K.F., Sze K.H., Lau S.K.P. and Yuen K.Y., The biosynthetic pathway for a thousand-year-old natural food colorant and citrinin in Penicillium marneffei, Scientific Reports. 2014, 4: 6728. |
| Researcher : Lee KW |
| Project Title: | Therapeutic targeting of liver cancer by use of monoclonal antibodies against CD47 |
| Investigator(s): | Lee KW, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 11/2012 |
| Project Title: | The role of cathepsin S (CTSS) and efficacy of CTSS targeted therapy in CD47+ tumor initiating cells-driven hepatocellular carcinoma |
| Investigator(s): | Lee KW, Ng IOL, Ma SKY |
| Department: | Pathology |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2013 |
| Project Title: | The role of Hepatitis B virus in regulation of liver cancer stem cells properties |
| Investigator(s): | Lee KW |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2013 |
| Completion Date: | 10/2014 |
| Project Title: | Hepatitis B virus promotes hepatocarcinogenesi through regulation of stemness factors |
| Investigator(s): | Lee KW, Sze MF |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 10/2013 |
| Project Title: | Clinical relevance and characterization of CD47 in hepatocellular carcinoma |
| Investigator(s): | Lee KW |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2013 |
| Project Title: | The role of cancer-associated fibroblasts (CAFs) in hepatocellular carcinoma |
| Investigator(s): | Lee KW |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | The clinical relevance and role of cancer-associated fibroblast-derived HGF in the regulation of liver tumor-initiating cells |
| Investigator(s): | Lee KW |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2014 |
| Project Title: | The roles of Nuclear factor (erythroid-derived 2)-like 2 in hepatocellular carcinoma |
| Investigator(s): | Lee KW |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2015 |
| List of Research Outputs |
| LO J., Ching H.H., Lau Y.T., CHENG Y.L.B., MA K.F., Lee K.W. and Ng I.O.L., Nuclear Factor Kappa B–mediated Cd47 Up-regulation Promotes Sorafenib Resistance And Its Blockade Synergizes The Effect Of Sorafenib In Hepatocellular Carcinoma In Mice, Hepatology. 2015. |
| Lee K.W., Austin Journal of Clinical Pathology, 2015. |
| Lee K.W., Cheung C.H., Lu P., LAU Y.T., Ma S.K.Y., TANG K.H., Tong M., LO J. and Ng I.O.L., Blockade of CD47 mediated CTSS-PAR2 signaling provides a therapeutic target for hepatocellular carcinoma, Hepatology. 2014, 60: 179-191. |
| Lee K.W., International Journal of Cancer and Clinical Research. 2015. |
| Lee K.W., Journal of Genetics and Genome Research. 2015. |
| Lee K.W., Targeting CD47 as a novel therapeutic strategy against hepatocellular carcinoma, National Institute of Cancer Research, TaiWan. 2014. |
| Lee K.W., The identification of liver cancer stem cells for treatment of hepatocellular carcinoma, Taipei Medical University, Taiwan. 2014. |
| Liu J., Lau Y.T., Chen J., Yong J., Tang K.D., Lo J., Ng I.O.L., Lee K.W. and Ling M.T., Polysaccharopeptide enhanced the anti-cancer effect of gamma-tocotrienol through activation of AMPK, BMC Complement Altern Med. 2014, 14: 303. |
| MA K.F., Ng I.O.L. and Lee K.W., Roles of Stearoyl-CoA desaturase-1 in hepatocellular carcinima, Journal of Liver: Disease and Transplantation. 2015. |
| Ma W., Sze M.F., Chan L.K., Lee M.F., Lee K.W., Wong C.C.L. and Ng I.O.L., RhoE/ROCK signaling modulates chemoresistance in HCC through IL6/JAK2/STAT3 pathways, New Horizons in Cancer Research Conference: Harnessing Breakthroughs – Targeting Cures. 2014. |
| Ma W., Sze M.F., Chan L.K., Lee M.F., Lee K.W., Wong C.C.L. and Ng I.O.L., Scholar-in-Training Award, New Horizons in Cancer Research Conference: Harnessing Breakthroughs – Targeting Cures (American Association for Cancer Research). 2014. |
| Tang K.D., Holzapfel N.M., Liu J., Lee K.W., Ma S.K.Y., Jovanovix L., An J., Russell P.J., Hutmacher D.W. and Ling M.T., Tie-2 regulates the stemness and metastatic properties of prostate cancer cells. , Oncotarget. 2015. |
| Tong M., Fung T.M., Luk T.C.S., Ng K.Y., Lee K.W., Lin C., Yam J.W.P., Chan K.W., Ng F., Zheng B., Yuan Y.F., Xie D., Lo C.M., Man K., Guan X. and Ma S.K.Y., ANXA3/JNK Signaling Promotes Self-Renewal and Tumor Growth, and Its Blockade Provides a Therapeutic Target for Hepatocellular Carcinoma, Stem Cell Reports. 2015. |
| Researcher : Lee MF |
| List of Research Outputs |
| Ma W., Sze M.F., Chan L.K., Lee M.F., Lee K.W., Wong C.C.L. and Ng I.O.L., RhoE/ROCK signaling modulates chemoresistance in HCC through IL6/JAK2/STAT3 pathways, New Horizons in Cancer Research Conference: Harnessing Breakthroughs – Targeting Cures. 2014. |
| Ma W., Sze M.F., Chan L.K., Lee M.F., Lee K.W., Wong C.C.L. and Ng I.O.L., Scholar-in-Training Award, New Horizons in Cancer Research Conference: Harnessing Breakthroughs – Targeting Cures (American Association for Cancer Research). 2014. |
| Tsang F.H., Au L.K.S., Fan N.Y., Lee M.F., Wong C.C.L., Ng I.O.L. and Wong C.M., HOTTIP, an oncogenic long non-coding RNA, is frequently up-regulated in hepatocellular carcinoma and is negatively regulated by tumor suppressive microRNA miR-125b, Liver International. 2015, 35: 1597. |
| Wong C.C.L., Tse P.W., Huang Y., Zhu Y., CHIU K.C., LAI K.H., Au L.K.S., Kai A.K.L., Lee M.F., WEI L., Tsang F.H., Lo C.L.R., Shi J., Zheng Y., Wong C.M. and Ng I.O.L., Lysyl Oxidase-like 2 Is Critical To Tumor Microenvironment And Metastatic Niche Formation In Hepatocellular Carcinoma, In: Snorry Thorgeirsen, Hepatology. 2014. |
| Wong C.M., WEI L., Au L.K.S., Fan N.Y., Zhou Y., Tsang F.H., Lee M.F., He X., Shi J., Wong C.C.L. and Ng I.O.L., miR-200b/200c/429 subfamily negatively regulates Rho/ROCK signaling pathway and suppresses HCC metastasis, Oncotarget . 2015, 6: 13658. |
| Researcher : Leung KF |
| List of Research Outputs |
| Lam C.W., Law C.Y., Leung K.F., Lai C.K., Chen S.P.L., Chan B., Chan K.Y., Yuen L.Y.P., Mak C.M. and Chan A.Y.W., NMR-based urinalysis for rapid diagnosis of β-ureidopropionase deficiency in a patient with Dravet syndrome, Clinica Chimica Acta. 2015, 440: 201-204. |
| Woo P.C.Y., Lam C.W., Tam W.T., Lee K.C., Yung K.Y., Leung K.F., Sze K.H., Lau S.K.P. and Yuen K.Y., The biosynthetic pathway for a thousand-year-old natural food colorant and citrinin in Penicillium marneffei, Scientific Reports. 2014, 4: 6728. |
| Researcher : Leung ON |
| Project Title: | Epigenetic modulation of Sox9 in HCC |
| Investigator(s): | Leung ON, Lo CLR |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Leung O.N., Wong C.C.L., Fan D.N., Kai A.K.L., Tung E.K., Xu M., Ng I.O.L. and Lo C.L.R., PIM1 regulates glycolysis and promotes tumor progression in hepatocellular carcinoma., Oncotarget. 2015. |
| Lo C.L.R., Leung O.N., Wong C.C.L., Kai A.K.L. and Ng I.O.L., Pim1 Is Upregulated By Hypoxia In Hepatocellular Carcinoma And Promotes Tumor Progression , International Liver Cancer Association Annual Conference 2014. |
| Researcher : Leung RYY |
| List of Research Outputs |
| Ip H.W., So J.C.C., Leung R.Y.Y., Chan J.Y., Sin P. and Lam C.C.K., Acquired factor VIII inhibitor and positive lupus anticoagulant testing on silica clotting time, International Journal of Laboratory Hematology. 2015, 37: 139-141. |
| Wong H., Hwang Y.Y., Leung R.Y.Y., Chan G.S.W., Khong P.L. and Kwong Y.L., Unilateral hearing loss due to lymphocytosis and a contralateral putamen lesion, Annals of Hematology. 2015, 94: 703-704. |
| Researcher : Leung SY |
| Project Title: | Identification of BRAF mutation in various stages of colorectal carcinogenesis and its relationship with KRAS mutation |
| Investigator(s): | Leung SY, Yuen ST |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2002 |
| Project Title: | Detail study of relationship of BRAF and KRAS mutation with microstatellite instability in colorectal cancer |
| Investigator(s): | Leung SY, Yuen ST |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Project Title: | Genomic screening for potential tumour suppressors silenced by promoter hypermethylation in gastric adenocarcinomas using cDNA microarray |
| Investigator(s): | Leung SY, Yuen ST, Chu KM, Fung TWK, Lin MC |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2005 |
| Project Title: | Outstanding Researcher Award 2006-2007 |
| Investigator(s): | Leung SY |
| Department: | Pathology |
| Source(s) of Funding: | Outstanding Researcher Award |
| Start Date: | 11/2007 |
| Project Title: | Research Output Prize (Faculty of Medicine) |
| Investigator(s): | Leung SY |
| Department: | Pathology |
| Source(s) of Funding: | Research Output Prize (in Faculty) |
| Start Date: | 11/2007 |
| Project Title: | Research Output Prize |
| Investigator(s): | Leung SY, Chan TL |
| Department: | Pathology |
| Source(s) of Funding: | Research Output Prize (in Faculty) |
| Start Date: | 12/2009 |
| List of Research Outputs |
| Hiyoshi Y., Schetter A.J., Okayama H., Inamura K., Anami K., Nguyen G.H., Horikawa I., Hawkes J.E., Bowman E.D., Leung S.Y. and Harris C.C., Increased MicroRNA-34b and -34c Predominantly Expressed in Stromal Tissues Is Associated with Poor Prognosis in Human Colon Cancer, PLOS ONE. 2015, 10: e0124899. |
| Leung S.Y., Integrative genomic profiling of gastric cancer, EMBO Workshop: Stem cells and epigenetics in cancer, Hong Kong, 16-18 October 2014. 2014. |
| Leung S.Y., Outstanding Women Professionals Award 2014, Hong Kong Women Professional & Entrepreneurs Association. 2014. |
| Leung S.Y., Whole-Genome Sequencing and Integrative Genomic Analysis of Gastric Cancer, Joint Conference of the 9th International Conference on Genomics (ICG-9) and the 3rd Shenzhen International Biotechnology Innovation Forum & Expo (SIBIFE-3), Shenzhen, China . 2014. |
| Leung S.Y., Whole-genome sequencing and comprehensive molecular profiling of gastric cancer, 2014 East-West Alliance Global Symposia: Li Ka Shing Faculty of Medicine Frontiers Series – MOOCs in Postmodern Asia & Big Data and Precision Medicine, Hong Kong. 2014. |
| Leung S.Y., Whole-genome sequencing and comprehensive molecular profiling of gastric cancer, EMBO|EMBL: Frontiers in Stem Cells & Cancer, EMBL Heidelberg, Germany, 29-31 March 2015. 2015. |
| Leung S.Y., Whole-genome sequencing and integrative genomic analysis of gastric cancer, Invited by Department of Genetics and Genomic Sciences and Institute for Genomics & Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, U.S.A.. 2014. |
| Leung S.Y., Whole-genome sequencing and integrative genomic analysis of gastric cancer, Invited by University Health Network, Toronto, Canada. 2014. |
| Leung S.Y., Whole-genome sequencing and integrative genomic analysis of gastric cancer, WuXiAppTec (Shanghai), China. 2014. |
| Leung W.K., Tong D.K.H., Leung S.Y., Chan S.Y., Tong S.M., Ho R.S.L., Chu K.M. and Law S.Y.K., Treatment of gastric metaplasia or dysplasia by endoscopic radiofrequency ablation: A pilot study, Hepato-Gastroenterology. 2015, 62: 52-55. |
| Researcher : Lin X |
| Project Title: | The role of Th17 cells in the development of experimental Sjogren's syndrome |
| Investigator(s): | Lin X, Lu L |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2014 |
| Completion Date: | 12/2014 |
| Project Title: | IMMUNOLOGY 2015™ AAI Annual Meeting; A Critical Role of Th17 Cells in the Development of Murine Sjogeren’s Syndrome |
| Investigator(s): | Lin X |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2015 |
| List of Research Outputs |
| Lin X., Tian J., Rui K., Ma K., Ko K.H., Wang S. and Lu L., The role of T helper 17 cell subsets in Sjogren's syndrome: similarities and differences between mouse model and humans, Annals of the Rheumatic Diseases. 2014, 73: e43-e43. |
| Researcher : Liu J |
| Project Title: | Identification and characterization of tumor-initiating cells in non-small cell lung carcinoma |
| Investigator(s): | Liu J, Wong MP |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 02/2013 |
| Completion Date: | 07/2014 |
| List of Research Outputs |
| Wong M.P., Liu J., XIAO Z., Tin P.C., Wang S. and Kwan T.K., Calcium/calmodulin-dependent protein kinase II alpha (CaMK2A) regulates the tumor initiating cell phenotype through SOX2 expression and modulates treatment response to anti-cancer drugs in lung adenocarcinoma. , Annual Scientific Meeting of the American Association for Cancer Research, Philadelphia. 2015. |
| Researcher : Lo CK |
| List of Research Outputs |
| Cheung A.N.Y., Wong G.W., Chan K.K., Yang M.S., Tsang C.H., Ji S.L., Lo C.K., Szeto E., Wong E.S.Y. and Ngan H.Y.S., Integrated human papillomavirus analysis as an adjunct for triage of atypical cervical cytology, In: ANY Cheung, OG Wong, KKY Chan, MS Yang, CH Tsang, SL Ji, CK Lo, E Szeto, E Wong, HYS Ngan, Hong Kong Med J. 2014. |
| Researcher : Lo CLR |
| Project Title: | Study of testis-specific protein Y-encoded (TSPY) in hepatocellular carcinoma |
| Investigator(s): | Lo CLR, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2012 |
| Project Title: | Identification of downstream targets of PIM1 in hepatocellular carcinoma |
| Investigator(s): | Lo CLR, Wong CCL |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2013 |
| Completion Date: | 06/2015 |
| Project Title: | Study of the downstream molecular mechanism of Sox9 in hepatocellular carcinoma |
| Investigator(s): | Lo CLR, Lee KW |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | International LIver Cancer Association Annual Conference 2014; Pim1 Is Upregulated By Hypoxia In Hepatocellular Carcinoma And Promotes Tumor Progression |
| Investigator(s): | Lo CLR |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2014 |
| Completion Date: | 09/2014 |
| Project Title: | Study of the role of Stanniocalcin 1 in hepatocellular carcinoma |
| Investigator(s): | Lo CLR, Wong CCL |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Kido T., Lo C.L.R., Li Y., Lee J., Tabatabai Z.L., Ng I.O.L. and Lau Y.F., The potential contributions of a Y-located protooncogene and its X homologue in sexual dimorphisms in hepatocellular carcinoma, Hum Pathol. 2014, 45(9): 1847-58. |
| Leung O.N., Wong C.C.L., Fan D.N., Kai A.K.L., Tung E.K., Xu M., Ng I.O.L. and Lo C.L.R., PIM1 regulates glycolysis and promotes tumor progression in hepatocellular carcinoma., Oncotarget. 2015. |
| Li L.F., Tse Y.H., Tsang C.P., Lo C.L.R., Lui W.M. and Leung G.K.K., IgG4-related hypertrophic pachymeningitis at the falx cerebrii with brain parenchymal invasion: a case report, World Neurosurgery. 2015, 84(2): 591. e7-591. |
| Lo C.L.R., Leung O.N., Wong C.C.L., Kai A.K.L. and Ng I.O.L., Pim1 Is Upregulated By Hypoxia In Hepatocellular Carcinoma And Promotes Tumor Progression , International Liver Cancer Association Annual Conference 2014. |
| Lo C.L.R., SKLLR Symposium 2014, Clinicopathological Conference. 2014. |
| She W.H., Chok K.S.H., Lo C.L.R., Chan S.C. and Lo C.M., Rare cause of jaundice in a post liver transplant patient, Transplant Infectious Disease. 2015, 17: 579-582. |
| Wong C.C.L., Tse P.W., Huang Y., Zhu Y., CHIU K.C., LAI K.H., Au L.K.S., Kai A.K.L., Lee M.F., WEI L., Tsang F.H., Lo C.L.R., Shi J., Zheng Y., Wong C.M. and Ng I.O.L., Lysyl Oxidase-like 2 Is Critical To Tumor Microenvironment And Metastatic Niche Formation In Hepatocellular Carcinoma, In: Snorry Thorgeirsen, Hepatology. 2014. |
| Wong C.C.L., Au L.K.S., Tse P.W., Xu M., LAI K.H., CHIU K.C., WEI L., Fan N.Y., Tsang F.H., Lo C.L.R., Wong C.M. and Ng I.O.L., Switching of pyruvate kinase isoform L to M2 promotes metabolic reprogramming in hepatocarcinogenesis, PLos One. 2014. |
| Researcher : Lo J |
| List of Research Outputs |
| LO J., Ching H.H., Lau Y.T., CHENG Y.L.B., MA K.F., Lee K.W. and Ng I.O.L., Nuclear Factor Kappa B–mediated Cd47 Up-regulation Promotes Sorafenib Resistance And Its Blockade Synergizes The Effect Of Sorafenib In Hepatocellular Carcinoma In Mice, Hepatology. 2015. |
| Lee K.W., Cheung C.H., Lu P., LAU Y.T., Ma S.K.Y., TANG K.H., Tong M., LO J. and Ng I.O.L., Blockade of CD47 mediated CTSS-PAR2 signaling provides a therapeutic target for hepatocellular carcinoma, Hepatology. 2014, 60: 179-191. |
| Liu J., Lau Y.T., Chen J., Yong J., Tang K.D., Lo J., Ng I.O.L., Lee K.W. and Ling M.T., Polysaccharopeptide enhanced the anti-cancer effect of gamma-tocotrienol through activation of AMPK, BMC Complement Altern Med. 2014, 14: 303. |
| Researcher : Loong F |
| List of Research Outputs |
| Au Yeung K.H.R., Chen W.Y.W., Guo T., Wong K.Y., Shimizu N., Tsuchiyama J., Loong F., Kwong Y.L. and Srivastava G., Receptor-type tyrosine-protein phosphatase kappa promoter hypermethylation correlates with unfavorable prognosis in nasal NK/T-cell lymphoma patients treated with SMILE regimen, The 60th Autumn Annual Meeting of the Japanese Society of Pathology. 第60回日本病理学会秋期特別総会, Japan, 2014. |
| Chen W.Y.W., Guo T., Shen L., Wong K.Y., Tao Q., Choi W.L., Au Yeung K.H.R., Chan Y.P., Wong M.L.Y., Tang J.C.O., Liu W.P., Li G.D., Shimizu N., Loong F., Tse E.W.C., Kwong Y.L. and Srivastava G., Receptor-type tyrosine-protein phosphatase k directly targets STAT3 activation for tumor suppression in nasal NK/T-cell lymphoma, Blood. United States of America, The American Society of Hematology, 2015, 125(10): 1589-600. |
| YIM L.H.R., Wong K.Y., Kwong Y.L., Loong F., Leung C.Y., Chu R., Lam W.W., Hui P.K., Lai R. and Chim J.C.S., Methylation of miR-155-3p in mantle cell and other non-Hodgkin's lymphoma, Oncotarget. 2014, in press. |
| Researcher : Lu L |
| Project Title: | Plasma cell development and its regulation in autoimmunity |
| Investigator(s): | Lu L |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2007 |
| Project Title: | Roles of leptin in regulating T cell function and autoimmune pathogenesis |
| Investigator(s): | Lu L |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Project Title: | Leptin regulates plasma cell generation and survival in autoimmune arthritis |
| Investigator(s): | Lu L |
| Department: | Pathology |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2014 |
| Project Title: | B-1 cell response and its regulation during influenza virus infection |
| Investigator(s): | Lu L, Ko KH |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 01/2014 |
| Project Title: | Outstanding Researcher Award 2012-13 |
| Investigator(s): | Lu L |
| Department: | Pathology |
| Source(s) of Funding: | Outstanding Researcher Award |
| Start Date: | 01/2014 |
| Project Title: | The role of B1 cells in the pathogenesis of autoimmune arthritis |
| Investigator(s): | Lu L |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2014 |
| Project Title: | 3rd International Conference on Immune Tolerance 2014; Regulatory B cells suppress autoimmune arthritis via inhibiting Th17 response |
| Investigator(s): | Lu L |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2014 |
| Completion Date: | 09/2014 |
| Project Title: | The Role of B cells in the pathogenesis of experimental Sjögren’s syndrome |
| Investigator(s): | Lu L |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2015 |
| Project Title: | Role of B cells in the pulmonary anti-viral immune response |
| Investigator(s): | Lu L, Ma K |
| Department: | Pathology |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - Major Research Project |
| Start Date: | 01/2015 |
| Project Title: | The role of B1 cells in the development of autoimmune arthritis |
| Investigator(s): | Lu L |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| List of Research Outputs |
| Chen J., Tian J., Tang X., Rui K., Ma J., Mao C., Liu Y., Lu L., Xu H. and Wang S., MiR-346 regulates CD4+CXCR5 + T cells in the pathogenesis of Graves' disease, Endocrine. 2015. |
| Gao J., Wu Y., Su Z., Amoah Barnie P., Jiao Z., Bie Q., Lu L., Wang S. and Xu H., Infiltration of Alternatively Activated Macrophages in Cancer Tissue Is Associated with MDSC and Th2 Polarization in Patients with Esophageal Cancer, PLoS ONE. 2014, 9: e104453. |
| Lin X., Tian J., Rui K., Ma K., Ko K.H., Wang S. and Lu L., The role of T helper 17 cell subsets in Sjogren's syndrome: similarities and differences between mouse model and humans, Annals of the Rheumatic Diseases. 2014, 73: e43-e43. |
| Liu Y., Tang X., Tian J., Zhu C., Peng H., Rui K., Wang Y., Mao C., Ma J. and Lu L., Th17/Treg Cells Imbalance and GITRL Profile in Patients with Hashimoto’s Thyroiditis, International Journal of Molecular Sciences. 2014, 15: 21674-21686. |
| Ma K., Li J., Fang Y. and Lu L., Roles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus, Int J Mol Sci. 2015, 16: 13084-13105. |
| Peng H., Liu Y., Tian J., Ma J., Tang X., Yang J., Rui K., Zhang Y., Mao C. and Lu L., Decreased expression of microRNA-125a-3p upregulates interleukin-23 receptor in patients with Hashimoto’s thyroiditis, Immunologic Research. 2015, 62: 129-136. |
| Tian J., Zhang Y., Yang X., Rui K., Tang X., Ma J., Chen J., Xu H., Lu L. and Wang S., Ficus carica Polysaccharides Promote the Maturation and Function of Dendritic Cells, International Journal of Molecular Sciences. 2014, 15: 12469-12479. |
| WU H., Lo Y., Luk D., Lau W.C.S., Lu L. and Mok T.M.Y., Alternatively activated dendritic cells derived from systemic lupus erythematosus patients have tolerogenic phenotype and function, Clinical Immunology. 2015, 156: 43-57. |
| Wang D., Feng X., Lu L., Konkel J.E., Zhang H., Chen Z., Li X., Gao X., Lu L. and Shi S., A CD8 T Cell/Indoleamine 2,3-Dioxygenase Axis Is Required for Mesenchymal Stem Cell Suppression of Human Systemic Lupus Erythematosus, Arthritis & Rheumatology. 2014, 66: 2234-2245. |
| Wang W., Jiao Z., Duan T., Liu M., Zhu B., Zhang Y., Xu Q., Wang R., Xiong Y., Xu H. and Lu L., Functional characterization of myeloid-derived suppressor cell subpopulations during the development of experimental arthritis, European Journal of Immunology. 2015, 45: 464-473. |
| Yuan J., Tang X., Yin K., Tian J., Rui K., Ma J., Mao C., Chen J., Lu L. and Xu H., GITRL as a genetic adjuvant enhances enterovirus 71 VP1 DNA vaccine immunogenicity, Immunologic Research. 2015, 62: 81-88. |
| Zhang X., Shen J., Man K., Chu E.S., Yau T.O., Sung J.C., Go M.Y., Deng J., Lu L., Wong V.W., Sung J.J., Farrell G. and Yu J., CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis, Journal of Hepatology. 2014, Epub on 2014-07-15. |
| Researcher : Lu P |
| List of Research Outputs |
| Lee K.W., Cheung C.H., Lu P., LAU Y.T., Ma S.K.Y., TANG K.H., Tong M., LO J. and Ng I.O.L., Blockade of CD47 mediated CTSS-PAR2 signaling provides a therapeutic target for hepatocellular carcinoma, Hepatology. 2014, 60: 179-191. |
| Researcher : Lui WC |
| List of Research Outputs |
| Lui W.C., Chan Y.F. and Ng R.K., PRMT1 activates leukemic stem cell program in MLL-rearranged leukemia, 56th ASH Annual Meeting and Exposition December 6-9, 2014, San Francisco, United States. 2014. |
| Researcher : MA KF |
| List of Research Outputs |
| LO J., Ching H.H., Lau Y.T., CHENG Y.L.B., MA K.F., Lee K.W. and Ng I.O.L., Nuclear Factor Kappa B–mediated Cd47 Up-regulation Promotes Sorafenib Resistance And Its Blockade Synergizes The Effect Of Sorafenib In Hepatocellular Carcinoma In Mice, Hepatology. 2015. |
| MA K.F., Ng I.O.L. and Lee K.W., Roles of Stearoyl-CoA desaturase-1 in hepatocellular carcinima, Journal of Liver: Disease and Transplantation. 2015. |
| Researcher : Ma ESK |
| List of Research Outputs |
| LUO Y., Sit A.K., Sihoe D.L.A., Suen W.S., Au T.W.K., Tang X., Ma E.S.K., Chan W.K., Wistuba I.I., Minna J.D., Tsao G.S.W. and Lam C.L.D., Aberrant large tumor suppressor 2 (LATS2) gene expression correlates with EGFR mutation and survival in lung adenocarcinomas, Lung Cancer. Elsevier, 2014, 85 (2): 282 - 292. |
| So J.C.C., Chan A.Y., Chan J.C. and Ma E.S.K., Alpha thalassemia trait masquerading as hemoglobin H disease due to co-existing primary myelofibrosis, Annals of Hematology. 2015, 94: 875-877. |
| Researcher : Ma K |
| List of Research Outputs |
| Lin X., Tian J., Rui K., Ma K., Ko K.H., Wang S. and Lu L., The role of T helper 17 cell subsets in Sjogren's syndrome: similarities and differences between mouse model and humans, Annals of the Rheumatic Diseases. 2014, 73: e43-e43. |
| Ma K., Li J., Fang Y. and Lu L., Roles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus, Int J Mol Sci. 2015, 16: 13084-13105. |
| Researcher : Ma SKY |
| Project Title: | Centre for MicroRNA Study - Basic Research and Clinical Potentials in Cancer |
| Investigator(s): | Ma SKY, Wong AST |
| Department: | Pathology |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 06/2012 |
| Project Title: | Characterization and clinical evaluation of the metastasis-suppressing function of TP53INP1 in hepatocellular carcinoma |
| Investigator(s): | Ma SKY |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2012 |
| Project Title: | Hepatitis B virus promotes hepatocarcinogenesis through induction of CD133+ cancer stem cells/tumor-initiating cells |
| Investigator(s): | Ma SKY, Guan X |
| Department: | Clinical Oncology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 01/2013 |
| Project Title: | Significance of Annexin A3 in CD133+ Cancer-Initiating Cells-Driven Hepatocellular Carcinoma |
| Investigator(s): | Ma SKY, Chan KW |
| Department: | Clinical Oncology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2013 |
| Project Title: | Outstanding Young Researcher Award 2012-13 |
| Investigator(s): | Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 01/2014 |
| Project Title: | A multidisciplinary study on hepatic cancer stem cells |
| Investigator(s): | Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Croucher Innovation Awards |
| Start Date: | 04/2014 |
| Project Title: | The use of anti-annexin A3 monoclonal antibody for the treatment of liver cancer |
| Investigator(s): | Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 05/2014 |
| Completion Date: | 04/2015 |
| Project Title: | miR-1246 and Wnt/β-catenin interaction in the control of CD133+ liver cancer stem cells driven hepatocellular carcinoma |
| Investigator(s): | Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Regulatory role of microRNA-1246 and Wnt/?catenin pathway interaction in CD133+ liver cancer stem cells-driven hepatocellular carcinoma |
| Investigator(s): | Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 01/2015 |
| Project Title: | PRMT6 in the control of glucose metabolic reprogramming in CD133+ liver cancer stem cells |
| Investigator(s): | Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2015 |
| Project Title: | A Multidisciplinary Study on CD133 Liver Cancer Stem Cells: Molecular Mechanisms, Clinical Relevance and Therapeutic Implications |
| Investigator(s): | Ma SKY, Guan X, Lo CM, Man K |
| Department: | Anatomy |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 06/2015 |
| Researcher : Ma W |
| Project Title: | AACR Annual Meeting 2015; Overexpression of APOBEC3B enhances invasiveness of hepatocellular carcinoma |
| Investigator(s): | Ma W |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2015 |
| Completion Date: | 04/2015 |
| List of Research Outputs |
| Ma W., Ho D.W.H. and Ng I.O.L., Overexpression of APOBEC3B enhances invasiveness of hepatocellular carcinoma, AACR annual meeting 2015. |
| Ma W., Sze M.F., Chan L.K., Lee M.F., Lee K.W., Wong C.C.L. and Ng I.O.L., RhoE/ROCK signaling modulates chemoresistance in HCC through IL6/JAK2/STAT3 pathways, New Horizons in Cancer Research Conference: Harnessing Breakthroughs – Targeting Cures. 2014. |
| Ma W., Sze M.F., Chan L.K., Lee M.F., Lee K.W., Wong C.C.L. and Ng I.O.L., Scholar-in-Training Award, New Horizons in Cancer Research Conference: Harnessing Breakthroughs – Targeting Cures (American Association for Cancer Research). 2014. |
| Researcher : Mak CM |
| List of Research Outputs |
| Chong Y.K., Ma L.C., Lo K.L., Lee C.K., Mak C.M., Kan N.C.A. and Lam C.W., Dystroglycanopathy with two novel POMT1 mutations in a Chinese boy with developmental delay and muscular dystrophy, In: Chong YK, Ma LC, Lo KL, Lee CK, Mak CM, Kan AN, Lam CW, European Journal of Paediatric Neurology. 2014, 18: 532-535. |
| Lam C.W., Law C.Y., Leung K.F., Lai C.K., Chen S.P.L., Chan B., Chan K.Y., Yuen L.Y.P., Mak C.M. and Chan A.Y.W., NMR-based urinalysis for rapid diagnosis of β-ureidopropionase deficiency in a patient with Dravet syndrome, Clinica Chimica Acta. 2015, 440: 201-204. |
| Law C.Y., Lam C.W., Ching D.C.K., Yau K.C., Ho T.W., Lai C.K. and Mak C.M., NMR-based urinalysis for beta-ketothiolase deficiency, Clinica Chimica Acta. 2015, 438: 222-225. |
| Researcher : Mak CY |
| List of Research Outputs |
| Mak C.Y., Wong G.W., Siu K.Y., Wong E.S.Y., Ngan W.Y., Wong R.W., Chan K.K., Ngan H.Y.S. and Cheung A.N.Y., FBI-1 Is Overexpressed in Gestational Trophoblastic Disease and Promotes Tumor Growth and Cell Aggressiveness of Choriocarcinoma via PI3K/Akt Signaling., Am J Pathol. 2015, 185(7): 2038-48. |
| Researcher : Mak TW |
| List of Research Outputs |
| Harris I.S., Treloar A.E., Inoue S., Sasaki M., Gorrini C., Lee K.C., Yung K.Y., Brenner D., Knobbe-Thomsen C.B., Cox M.A., Elia A., Berger T., Cescon D.W., Adeoye A., Brüstle A., Molyneux S.D., Mason J.M., Li W.Y., Yamamoto K., Wakeham A., Berman H.K., Khokha R., Done S.J., Kavanagh T.J., Lam C.W. and Mak T.W., Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression, Cancer Cell. 2015, 27: 211-222. |
| Researcher : Man PS |
| List of Research Outputs |
| Cai Q., Zhang B., Sung H., Low S.K., Kweon S.S., Lu W., Shi J., Long J., Wen W., Choi J.Y., Noh D.Y., Shen C.Y., Matsuo K., Teo S.H., Kim M.K., Khoo U.S., Iwasaki M., Hartman M., Takahashi A., Ashikawa K., Matsuda K., Shin M.H., Park M.H., Zheng Y., Xiang Y.B., Ji B.T., Park S.K., Wu P.E., Hsiung C.N., Ito H., Kasuga Y., Kang P., Mariapun S., Ahn S.H., Kang H.S., Chan Y.K., Man P.S., Iwata H., Tsugane S., Miao H., Liao J., Nakamura Y., Kubo M., Consortium D.G., Delahanty R.J., Zhang Y., Li B., Li C., Gao Y.T., Shu X.O., Kang D. and Zheng W., Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1, Nat Genet. 2014, 46(8): 886-90. |
| Khongkow P., Karunarathna U., Khongkow M., Gong C., Gomes A.R., Yague E., Monteiro L.J., Kongsema M., Zona S., Man P.S., Tsang J.W.H., Coombes R.C., Wu K.J., Khoo U.S., Medema R.H., Freire R. and Lam E.W., FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance, Oncogene. 2014, 33(32): 4144-55. |
| Khongkow P., Gomes A.R., Gong C., Man P.S., Tsang J.W.H., Zhao F., Monteiro L.J., Coombes R.C., Medema R.H., Khoo U.S. and Lam E.W., Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast cancer paclitaxel resistance, Oncogene. 2015. |
| Researcher : Mao X |
| Project Title: | American Association for Cancer Research Annual Meeting 2015; Upregulation of S100P by caveolin-1 drives tumorigenesis and metastasis in hepatocellular carcinoma under hypoxic stress |
| Investigator(s): | Mao X |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2015 |
| Completion Date: | 04/2015 |
| Project Title: | The role of mitochondria-targeted Heme Oxygenase-1 in liver cancer development and progression |
| Investigator(s): | Mao X, Yam JWP |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Mao X., WONG Y.S.S., Ko F.C.F. and Yam J.W.P., Upregulation of S100P by caveolin-1 drives tumorigenesis and metastasis in hepatocellular carcinoma under hypoxic stress, 2015 American Association for Cancer Research Annual Meeting. 2015. |
| Researcher : Nanji AA |
| Project Title: | 10th Congress of the International Society for Biomedical Research on Alcoholism Mechanisms of Apoptosis in Alcoholic Liver Disease |
| Investigator(s): | Nanji AA |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2000 |
| Researcher : Ng IOL |
| Project Title: | Characterization of the roles of hepatitis B virus X protein in liver cancer |
| Investigator(s): | Ng IOL, Chan DW |
| Department: | Pathology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 09/2006 |
| Project Title: | Outstanding Research Student Supervisor Award 2007-2008 |
| Investigator(s): | Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Outstanding Research Student Supervisor Award |
| Start Date: | 10/2008 |
| Project Title: | The Use of Anti-DKK1 (anti-Dickkopf-1) Monoclonal Antibody for Treatment of Liver Cancer |
| Investigator(s): | Ng IOL, Tung KK |
| Department: | Pathology |
| Source(s) of Funding: | Innovation and Technology Support Programme (Tier 3) |
| Start Date: | 09/2011 |
| Project Title: | Significance of RhoE dysregulation in liver cancer and metastasis |
| Investigator(s): | Ng IOL, Chan LK, Wong CM |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2011 |
| Project Title: | Dissecting the gender disparity of hepatocellular carcinoma: Roles of HBV X protein and androgen receptor |
| Investigator(s): | Ng IOL, Chiu YT |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2013 |
| Project Title: | Role of hypoxia-inducible miR-210 in liver cancer |
| Investigator(s): | Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2013 |
| Project Title: | Cancer Biology |
| Investigator(s): | Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Croucher Summer Courses |
| Start Date: | 08/2013 |
| Project Title: | The role of Lgr5 in liver cancer |
| Investigator(s): | Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Liver cancer research - From bench to translational applications |
| Investigator(s): | Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Croucher Senior Medical Research Fellowships |
| Start Date: | 01/2014 |
| Project Title: | Delineation of the role of RSK2 and their natural mutants in liver cancer |
| Investigator(s): | Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | International Liver Cancer Association Annual Meeting 2014; Dishevelled 3 (Dvl3) Is Overexpressed In Hepatocellular Carcinoma And Promotes Cancer Stemness |
| Investigator(s): | Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2014 |
| Completion Date: | 09/2014 |
| Project Title: | Delineation of the role of RPS6KA3, which encodes p90 ribosomal S6 kinase 2 (RPS6KA3), and their natural mutants in liver cancer |
| Investigator(s): | Ng IOL, Chan LK, Chiu YT, Ho DWH |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2014 |
| Project Title: | The role of SUMO-specific protease SENP1 in liver cancer |
| Investigator(s): | Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2015 |
| Project Title: | Characterization of functions of RhoE/ROCK pathway in regulating chemoresistance of liver cancer |
| Investigator(s): | Ng IOL, Ma W |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Cheung P.F.Y., Yip C.W., Wong C.L., Fong D.Y.T., Ng W.C.L., Wan M.Y.A., Wong C.K., Cheung T.T., Ng I.O.L., Poon R.T.P., Fan S.T. and Cheung S.T., Granulin-epithelin precursor renders hepatocellular carcinoma cells resistant to natural killer cytotoxicity, Cancer Immunology Research. 2014, 2(12): 1209-1219. |
| Ho D.W.H. and Ng I.O.L., uGPA: unified Gene Pathway Analyzer package for high-throughput genome-wide screening data provides mechanistic overview on human diseases, Clinica Chimica Acta. 2015, 441: 105-108. |
| Kido T., Lo C.L.R., Li Y., Lee J., Tabatabai Z.L., Ng I.O.L. and Lau Y.F., The potential contributions of a Y-located protooncogene and its X homologue in sexual dimorphisms in hepatocellular carcinoma, Hum Pathol. 2014, 45(9): 1847-58. |
| LO J., Ching H.H., Lau Y.T., CHENG Y.L.B., MA K.F., Lee K.W. and Ng I.O.L., Nuclear Factor Kappa B–mediated Cd47 Up-regulation Promotes Sorafenib Resistance And Its Blockade Synergizes The Effect Of Sorafenib In Hepatocellular Carcinoma In Mice, Hepatology. 2015. |
| Lee K.W., Cheung C.H., Lu P., LAU Y.T., Ma S.K.Y., TANG K.H., Tong M., LO J. and Ng I.O.L., Blockade of CD47 mediated CTSS-PAR2 signaling provides a therapeutic target for hepatocellular carcinoma, Hepatology. 2014, 60: 179-191. |
| Leung O.N., Wong C.C.L., Fan D.N., Kai A.K.L., Tung E.K., Xu M., Ng I.O.L. and Lo C.L.R., PIM1 regulates glycolysis and promotes tumor progression in hepatocellular carcinoma., Oncotarget. 2015. |
| Liu J., Lau Y.T., Chen J., Yong J., Tang K.D., Lo J., Ng I.O.L., Lee K.W. and Ling M.T., Polysaccharopeptide enhanced the anti-cancer effect of gamma-tocotrienol through activation of AMPK, BMC Complement Altern Med. 2014, 14: 303. |
| Lo C.L.R., Leung O.N., Wong C.C.L., Kai A.K.L. and Ng I.O.L., Pim1 Is Upregulated By Hypoxia In Hepatocellular Carcinoma And Promotes Tumor Progression , International Liver Cancer Association Annual Conference 2014. |
| MA K.F., Ng I.O.L. and Lee K.W., Roles of Stearoyl-CoA desaturase-1 in hepatocellular carcinima, Journal of Liver: Disease and Transplantation. 2015. |
| Ma W., Ho D.W.H. and Ng I.O.L., Overexpression of APOBEC3B enhances invasiveness of hepatocellular carcinoma, AACR annual meeting 2015. |
| Ma W., Sze M.F., Chan L.K., Lee M.F., Lee K.W., Wong C.C.L. and Ng I.O.L., RhoE/ROCK signaling modulates chemoresistance in HCC through IL6/JAK2/STAT3 pathways, New Horizons in Cancer Research Conference: Harnessing Breakthroughs – Targeting Cures. 2014. |
| Ma W., Sze M.F., Chan L.K., Lee M.F., Lee K.W., Wong C.C.L. and Ng I.O.L., Scholar-in-Training Award, New Horizons in Cancer Research Conference: Harnessing Breakthroughs – Targeting Cures (American Association for Cancer Research). 2014. |
| Ng I.O.L., Asian Journal of Surgery. 2014. |
| Ng I.O.L., Dishevelled 3 (Dvl3) Is Overexpressed In Hepatocellular Carcinoma And Promotes Cancer Stemness, Oral Communication, International Liver Cancer Association Annual meeting, Kyoto. 2014. |
| Ng I.O.L., Genes and Cancer, 2014. |
| Ng I.O.L., Journal of Gastroenterology and Hepatology. 2014. |
| Ng I.O.L., Journal of Hepatocellular Carcinoma (Editorial Board). 2014. |
| Ng I.O.L., Liver Cancer. 2014. |
| Ng I.O.L., Pre-clinical drug testing platform in HCC - A step closer to personalized cancer therapy, Laennec Society Meeting, Paris. 2015. |
| Ng I.O.L., Sze M.F. and Chu K.Y., Role of hepatitis B virus X protein in liver cancer, Hong Kong Med J. 2015, 21 Suppl 4: 27-30. |
| Ng I.O.L., The World Academy Of Science Prize In Medical Sciences 2014, The World Academy Of Science (TWAS). 2014. |
| Tang H.M.V., Gao W., Chan C.P., Cheng Y., Chaudhary V., Deng J., Yuen K.S., Wong C.M., Ng I.O.L., Kok K.H., Zhou J. and Jin D., Requirement of CRTC1 coactivator for hepatitis B virus transcription, Nucleic Acids Res. 2014, 42(20): 12455-68. |
| Tsang F.H., Au L.K.S., Fan N.Y., Lee M.F., Wong C.C.L., Ng I.O.L. and Wong C.M., HOTTIP, an oncogenic long non-coding RNA, is frequently up-regulated in hepatocellular carcinoma and is negatively regulated by tumor suppressive microRNA miR-125b, Liver International. 2015, 35: 1597. |
| Wong C.C.L., Tse P.W., Huang Y., Zhu Y., CHIU K.C., LAI K.H., Au L.K.S., Kai A.K.L., Lee M.F., WEI L., Tsang F.H., Lo C.L.R., Shi J., Zheng Y., Wong C.M. and Ng I.O.L., Lysyl Oxidase-like 2 Is Critical To Tumor Microenvironment And Metastatic Niche Formation In Hepatocellular Carcinoma, In: Snorry Thorgeirsen, Hepatology. 2014. |
| Wong C.C.L. and Ng I.O.L., Pyruvate Kinase M2 Promoted Aerobic Glycolysis And Growth Of Hepatocellular Carcinoma, Keystone Symposia Conference - Integrating Metabolism And Tumor Biology. 2015. |
| Wong C.C.L., Au L.K.S., Tse P.W., Xu M., LAI K.H., CHIU K.C., WEI L., Fan N.Y., Tsang F.H., Lo C.L.R., Wong C.M. and Ng I.O.L., Switching of pyruvate kinase isoform L to M2 promotes metabolic reprogramming in hepatocarcinogenesis, PLos One. 2014. |
| Wong C.L., Cheung P.F.Y., Yip C.W., Chan K.F., Ng I.O.L., Fan S.T. and Cheung S.T., Antibody against granulin-epithelin precursor sensitizes hepatocellular carcinoma to chemotherapeutic agents, Molecular Cancer Therapeutics. 2014, 13(12): 3001-3012. |
| Wong C.M., WEI L., Au L.K.S., Fan N.Y., Zhou Y., Tsang F.H., Lee M.F., He X., Shi J., Wong C.C.L. and Ng I.O.L., miR-200b/200c/429 subfamily negatively regulates Rho/ROCK signaling pathway and suppresses HCC metastasis, Oncotarget . 2015, 6: 13658. |
| ZHANG Y., Yang J., ZHANG J., Sun L., Hirankarn N., Pan H.F., Lau W.C.S., Chan T.M., Lee T.L., Leung A.M., Mok C.C., ZHANG L., WANG Y., Shen J.J., Wong S.N., Lee K.W., Ho M.H.K., Lee P.P.W., Chung B.H.Y., Chong C.Y., Wong R.W.S., Mok T.M.Y., Wong W.H.S., Tong K.L., Tse N.K.C., LI X.P., Avihingsanon Y., Rianthavorn P., SDeekajorndej T., Shotelersuk V., Suphapeetiporn K., Shotelersuk V., Ying S.K.Y., Fung S.K.S., Lai W.M., Wong C.M., Ng I.O.L., Sham P.C., Garcia-Barcelo M.M., Cherny S.S., Cui Y., Sham P.C., Yang S., Ye D.Q., Zhang X.J., Lau Y.L. and Yang W., Genome-wide search followed by replication reveals genetic interaction of CD80 and ALOX5AP associated with systemic lupus erythematosus in Asian populations, Annuals of Rheumatic Diseases. 2015. |
| Zhang Y., ZHANG J., Yang J., WANG Y., ZHANG L., Zuo X., Sun L., Pan H.F., Hirankarn N., WANG T., CHEN R., Ying D., Shen J.J., Lee T.L., Lau W.C.S., Chan D.T.M., Leung A.M.H., Mok C.C., Wong S.N., Lee K.W., Ho M.H.K., Lee P.P.W., Chung B.H.Y., Chong C.Y., Wong R.W.S., Mok T.M.Y., Wong W.H.S., Tong K.L., Tse N.K.C., Li X.P., Avihingsanon Y., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Shotelersuk V., Ying S.K.Y., Fung S.K.S., Lai W.M., Wong C.M., Ng I.O.L., Garcia-Barcelo M.M., Cherny S.S., Tam P.K.H., Sham P.C., Yang S., Ye D.Q., Cui Y., Zhang X.J., Lau Y.L. and Yang W., Meta-analysis of GWAS on two Chinese populations followed by replication identifies novel genetic variants on the X chromosome associated with systemic lupus erythematosus, Human Molecular Genetics. 2015, 24(1): 274-284. |
| Zhang Y., Wang Y., Yang J., ZHANG J., Sun L., Hirankarn N., Pan C.F., Lau W.C.S., Chan T.M., Lee T.L., Leung A.M.H., Mok C.C., ZHANG L., SHEN J., Wong S.N., Lee K.W., Ho M.H.K., Lee P.P.W., Chung B.H.Y., Chong C.Y., Wong R.W.S., Mok T.M.Y., Wong W.H.S., Tong K.L., Tse N.K., Li X.P., Avihingsanon Y., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Shotelersuk V., Ying S.K., Fung S.K., Lai W.M., Wong C.M., Ng I.O.L., Garcia-Barcelo M.M., Cherny S.S., Tam P.K.H., Sham P.C., Yang S., Ye D.Q., Cui Y., Zhang X.J., Yang W. and Lau Y.L., Meta-analysis of two Chinese populations identifies an autoimmune disease risk allele in 22q11.21 as associated with systemic lupus erythematosus, Arthritis Research & Therapy. 2015, 17: 67. |
| Researcher : Ng RK |
| Project Title: | The functional role of epigenetic memory in the differentiation plasticity of induced pluripotent stem cells |
| Investigator(s): | Ng RK |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Project Title: | Function of PRMT1 in the establishment of leukemia stem cell |
| Investigator(s): | Ng RK |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2013 |
| Project Title: | The role of PRMT1 in activation of leukemia stem cell program in MLL-rearranged leukemia |
| Investigator(s): | Ng RK, Yiu SM, Chan LC |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Function of polycomb protein Bmi-1 in hematopoietic Wnt signaling pathway |
| Investigator(s): | Ng RK |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | International Society for Stem Cell Research ISSCR 2015 Annual Meeting; Epigenetic function of Bmi-1 in the regulation of hematopoietic stem cell self-renewal |
| Investigator(s): | Ng RK |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2015 |
| Project Title: | Dysregulation of DNA methylation in MLL-rearranged leukemia |
| Investigator(s): | Ng RK |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Waye M.M.Y., Baum L., Boyde T.R.C., Chan K.K.K., Cherny S.S., Choy F., Garcia-Barcelo M.M., Gong Z., Kagawa H., Kotaka M., Lee C.Y., Lee S.M.Y., Li H.Y., Meng H., Ng R.K., Ng T.B., Pollard J., Qi R., Shen D.W., Tam S.S.W., Tsang F.S.Y., Wasylyk B., Xue H. and Siu C.O., Genetics and Epigenetics of Bipolar Disorder, Journal of Biochemistry and Molecular Biology in the Post Genomic Era. 2014, 2 (2). |
| Researcher : Ngan HYS |
| Project Title: | High dose cis-platinum and cyclophosphamide vs taxol in ovarian cancer |
| Investigator(s): | Ngan HYS, Wong RLC |
| Department: | Obstetrics & Gynaecology |
| Source(s) of Funding: | Other Funding Scheme |
| Start Date: | 07/1994 |
| Project Title: | Functional characterization and clinical significance of DNp73-C35 in ovarian cancer |
| Investigator(s): | Ngan HYS, Chan KKL, Cheung ANY, Leung THY |
| Department: | Obstetrics & Gynaecology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2011 |
| Completion Date: | 09/2014 |
| Project Title: | Clinical significance and application of HPV-related microRNAs in cervical pre-maglinant lesions and cancer |
| Investigator(s): | Ngan HYS, Liu S, Ng EKO, Cheung ANY, Chan KKL, Kwong A |
| Department: | Obstetrics & Gynaecology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 01/2013 |
| Project Title: | Roles of CD55(+) population and HPV viral proteins on tumor progression in cervical cancer cells |
| Investigator(s): | Ngan HYS, Leung THY, Cheung ANY, Chan KKL |
| Department: | Obstetrics & Gynaecology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2013 |
| Completion Date: | 08/2014 |
| Project Title: | Roles of HPV-E6 protein and CD55(+) population in regulating radio-resistance in cervical cancer cells |
| Investigator(s): | Ngan HYS, Chan KKL, Leung THY, Cheung ANY |
| Department: | Obstetrics & Gynaecology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2013 |
| Project Title: | Functional characterization of subpopulation cells expressing transferrin receptor (CD71) and the roles of HPV viral protein in cervical cancer |
| Investigator(s): | Ngan HYS, Leung THY, Chan KKL |
| Department: | Obstetrics & Gynaecology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Functional characterization of CD71(+) population and the roles of HPV-E6 protein in cervical cancer |
| Investigator(s): | Ngan HYS, Chan KKL, Cheung ANY, Leung THY, Siu KY |
| Department: | Obstetrics & Gynaecology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2014 |
| Project Title: | Elucidating the potential role of CD109 as a cancer stem-like cell marker in cervical cancer |
| Investigator(s): | Ngan HYS, Leung THY, Chan KKL |
| Department: | Obstetrics & Gynaecology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2015 |
| List of Research Outputs |
| Mak C.Y., Wong G.W., Siu K.Y., Wong E.S.Y., Ngan W.Y., Wong R.W., Chan K.K., Ngan H.Y.S. and Cheung A.N.Y., FBI-1 Is Overexpressed in Gestational Trophoblastic Disease and Promotes Tumor Growth and Cell Aggressiveness of Choriocarcinoma via PI3K/Akt Signaling., Am J Pathol. 2015, 185(7): 2038-48. |
| Researcher : Ngan WY |
| List of Research Outputs |
| Mak C.Y., Wong G.W., Siu K.Y., Wong E.S.Y., Ngan W.Y., Wong R.W., Chan K.K., Ngan H.Y.S. and Cheung A.N.Y., FBI-1 Is Overexpressed in Gestational Trophoblastic Disease and Promotes Tumor Growth and Cell Aggressiveness of Choriocarcinoma via PI3K/Akt Signaling., Am J Pathol. 2015, 185(7): 2038-48. |
| Researcher : Nicholls JM |
| Project Title: | Susceptibility of the upper respiratory tract to influenza virus infection following desialyation |
| Investigator(s): | Nicholls JM, Chan MCW, Kwong DLW |
| Department: | Pathology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2009 |
| Project Title: | Molecular determinants of H9N2 virus haemagglutinin and neuraminidase affecting virus tropism for the human and swine respiratory tract |
| Investigator(s): | Nicholls JM, Chan WY, Mok KP |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 11/2013 |
| Project Title: | Sialoglyco 2014; Glycomic Characterization of Respiratory Tract Tissues of Ferrets Shows Expression of Different Sialylatyed Glycans to Humans: Implications for the Use of Ferrets in Influenza Virus Infection Studies. |
| Investigator(s): | Nicholls JM |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2014 |
| List of Research Outputs |
| Chan M.C.W., Kwong H.Y. and Nicholls J.M., Susceptibility of the Upper Respiratory Tract to Influenza Virus Infection Following Desialyation (Abstract & poster presentation), Health Research Symposium 2014, 15 November 2014, Hong Kong. 2014, P132-Ab0100. |
| Chan W.Y., Fish E. and Nicholls J.M., Prevention and Treatment of Swine Origin Influenza Virus (S-OIV) through the Use of Interferon: An in vivo and ex vivo Study (Abstract & poster presentation), Health Research Symposium 2014, 15 November 2014, Hong Kong. 2014, P115-Ab0101. |
| Chan W.Y., Hemida M.G., Kayali G., Chu K.W., Poon L.L.M., Alnaeem A., Ali M.A., Tao K.P., Ng I.H.Y., Chan M.C.W., Guan Y., Nicholls J.M. and Peiris J.S.M., Tropism and replication of Middle East respiratory syndrome coronavirus from dromedary camels in the human respiratory tract: an in-vitro and ex-vivo study, Lancet Respiratory Medicine. 2014, 2(10): 813-22. |
| Jia N., Barclay W.S., Roberts K., Yen H., Chan W.Y., Lam A.K., Air G., Peiris J.S.M., Dell A., Nicholls J.M. and Haslam S.M., Glycomic characterization of respiratory tract tissues of ferrets: implications for its use in influenza virus infection studies, Journal of Biological Chemistry. 2014, 289(41): 28489-504. |
| Leung C.Y.H., Nicholls J.M., Ho C.K., Sia S.F., Mok K.P., Doak S.A., Cheung P.P.H., Hui P.Y., Chan W.Y., Guan Y., Akira S. and Peiris J.S.M., Highly pathogenic avian influenza A H5N1 and pandemic H1N1 virus infections have different phenotypes in Toll-like Receptor (TLR) 3 knock-out mice, Journal of General Virology. 2014, 95(Pt 9): 1870-9. |
| Nicholls J.M., Tsai P.N., Chan W.Y., Hui P.Y., Chan M.C.W., Peiris J.S.M., Chan K.H., Yuen K.Y. and To K.K.W., Fatal H7N9 pneumonia complicated by viral infection of a prosthetic cardiac valve – An autopsy study, Journal of Clinical Virology. 2014, 61(3): 466-9. |
| Nicholls J.M., Pathology Education: SY17-1 TEACHING AND EVALUATION OF BASIC PATHOLOGICAL SCIENCES IN A GENERATION OF PROBLEM BASED LEARNING., In: Nicholls J, Pathology. 2014. |
| Yen H., Liang C.H., Wu C.Y., Forrest H.L., Ferguson A., Choy K.T., Jones J., Wong D.D.Y., Cheung P.P.H., Li O.T.W., Yuen K.M., Chan W.Y., Poon L.L.M., Chan M.C.W., Nicholls J.M., Krauss S., Wong C.H., Webster R.G., Webby R. and Peiris J.S.M., Hemagglutinin–neuraminidase Balance Confers Respiratory-Droplet Transmissibility of the Pandemic H1N1 Influenza Virus in Ferrets (Abstract & poster presentation), Health Research Symposium 2014, 15 November 2014, Hong Kong. 2014, P66-Ab0011. |
| Yen H., ZHOU J., Choy K.T., Sia S.F., TENG O., Ng I.H.Y., Fang J., Hu Y., Wang W., Cowling B.J., Nicholls J.M., Guan Y. and Peiris J.S.M., The R292K mutation that confers resistance to neuraminidase inhibitors leads to competitive fitness loss of A/Shanghai/1/2013(H7N9) influenza virus in ferrets, Journal of Infectious Diseases. 2014, 210 (12): 1900-8. |
| Researcher : Shek TWH |
| List of Research Outputs |
| Chiu W.Y.J., Serra S., Kamel-Reid S., Zhang T., McNamara M.G., Bedard P.L., Hedley D., Moore M., Dhani N.C., Shek T.W.H., Kwong Y.L., Yau T.C.C., Doherty M. and Knox J.J., Next generation sequencing: profiling gallbladder cancer, Gastrointestinal Cancers Symposium 2015. |
| Tsang Y.P., Lang H.H.B. and Shek T.W.H., Assessing the short- and long-term outcomes after resection of benign insulinoma, ANZ Journal of Surgery. 2014, Epub on 2014-10-23. |
| Researcher : Siu KY |
| Project Title: | Effects of folate and folate receptor on ovarian and endometrial cancer: an in vitro study |
| Investigator(s): | Siu KY, Cheung ANY |
| Department: | Pathology |
| Source(s) of Funding: | American Institute for Cancer Research (AICR) - General Award |
| Start Date: | 07/2006 |
| Project Title: | p21-activated kinase 4: a prognostic and therapeutic target for ovarian carcinoma? |
| Investigator(s): | Siu KY, Cheung ANY, Ngan HYS |
| Department: | Pathology |
| Source(s) of Funding: | The Hong Kong Anti-Cancer Society (HKACS) - General Award |
| Start Date: | 10/2007 |
| List of Research Outputs |
| Mak C.Y., Wong G.W., Siu K.Y., Wong E.S.Y., Ngan W.Y., Wong R.W., Chan K.K., Ngan H.Y.S. and Cheung A.N.Y., FBI-1 Is Overexpressed in Gestational Trophoblastic Disease and Promotes Tumor Growth and Cell Aggressiveness of Choriocarcinoma via PI3K/Akt Signaling., Am J Pathol. 2015, 185(7): 2038-48. |
| Researcher : So JCC |
| Project Title: | Establishment of a Molecular Strategy for Direct Genotypic Characterisation of Moderate and Severe Haemophilia A in Hong Kong |
| Investigator(s): | So JCC |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2012 |
| Completion Date: | 05/2015 |
| Project Title: | Determination of the eaxct copy number variation in alpha globin genes and investigation of its effect on the phenotype of beta thalassaemia intermedia |
| Investigator(s): | So JCC |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2014 |
| List of Research Outputs |
| Chan C.Y.J., Trendell-Smith N.J., So J.C.C. and Kwong Y.L., Subtle skin involvement in nodal γδ peripheral T-cell lymphoma, The Journal of Dermatology. 2015, 42: 328-330. |
| Chua G.T., Chow K.C., So J.C.C. and Cheuk K.L.D., Aleukaemic leukaemia presenting with pathological fracture, Case Reports. 2014, 2014: bcr2014204690-bcr2014204690. |
| Ip H.W., So J.C.C., Leung R.Y.Y., Chan J.Y., Sin P. and Lam C.C.K., Acquired factor VIII inhibitor and positive lupus anticoagulant testing on silica clotting time, International Journal of Laboratory Hematology. 2015, 37: 139-141. |
| Ip H.W. and So J.C.C., Deep molecular response in chronic myelogenous leukemia: ensuring accuracy and consistency, Leukemia. 2015. |
| Liu A.P.Y., Chan G.C.F., Chung B.H.Y. and So J.C.C., Infant onset pancytopenia: A Case Report of Fanconi Anaemia managed with Matched-Sibling Cord Blood Transplantation (poster presentation), 50th Anniversary Scientific Meeting, Dept of Paed & Adol Med, HKU, 29-30 November 2014. |
| Ng H.Y., Wan T.S.K., So J.C.C. and Chim J.C.S., Epigenetic inactivation of DAPK1, p14ARF, mir-34a and -34b/c in acute promyelocytic leukaemia, Journal of Clinical Pathology. 2014, 67: 626-631. |
| So J.C.C., Chan A., Chung L.P., Siu L., Wong W.S. and Wong K.F., A comparison of high resolution melting, allele-specific priming and Sanger sequencing for the detection of BRAFV600E mutation in hairy cell leukaemia from different haematological specimens, Pathology. 2014, 46: 533-537. |
| So J.C.C., Chan A.Y., Chan J.C. and Ma E.S.K., Alpha thalassemia trait masquerading as hemoglobin H disease due to co-existing primary myelofibrosis, Annals of Hematology. 2015, 94: 875-877. |
| So J.C.C., Chiang A.K.S., Kan S.Y.A., Lee V.C.Y. and Ng E.H.Y., Beta thalassaemia intermedia due to silent alpha globin gene quadruplication in an infant, Pathology. 2014, 46: 570-572. |
| So J.C.C., Chan K.H., Pang A.W.K., Chan J.K.F. and Kwong Y.L., Diganosis of brainstem involvement in NK/T cell lymphoma, Annals of Hematology. 2014, 93: 1433. |
| So J.C.C., Faculty Teaching Medal, The University of Hong Kong. 2015. |
| So J.C.C., Liu A.K., Tsang M.H., Ngai D.Y., Leung K.S. and Chan A.Y., Genetic basis of persistent red blood cell microcytosis in the Chinese unexplained by phenotypical testing, Journal of Clinical Pathology. 2015, 68: 69-72. |
| So J.C.C., Liu A.K., Tsang M.H., Ngai D.Y., Leung K.S. and Chan A.Y., Occult alpha globin gene mutations are the commonest causes of red cell microcytosis unexplained by phenotypic testing, Annual Scientific Meetings of the HAA (Haematology Society of Australia and New Zealand, the Australian & New Zealand Society of Blood Transfusion and the Australasian Society of Thrombosis and Haemostasis), Australia. 2014. |
| So J.C.C., Where have all the thalassaemias gone?, Annual general meeting of the Hong Kong Society for the Study of Thalassaemia. 29 June 2015. 2015. |
| So J.C.C., Where have all the thalassaemias gone?, Department of Chemical Pathology, CUHK, 20 March 2015. 2015. |
| Researcher : Srivastava G |
| Project Title: | Molecular features and functional consequences of a novel recurrent t(14;20)(q32;q13.12)/IGHS?PRKCBP1 translocation in gastric and other B-cell non-Hodgkins lymphomas |
| Investigator(s): | Srivastava G |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2011 |
| Project Title: | Effect of t(11;14)(p13;q32) translocation on the expression of PDHX, the telomeric gene on chromosome 11p13, in GCB-derived lymphomas |
| Investigator(s): | Srivastava G |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2012 |
| Project Title: | Epigenetic silencing of the lymphocyte homing receptor CD44 in reactive germinal center B cells (GCB) and its activation in GCB-derived lymphomas by aberrant promoter hypomethylation |
| Investigator(s): | Srivastava G, Choi WL |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2012 |
| Project Title: | The roles of FOXP1 and its N-terminally truncated isoforms in the pathogenesis of diffuse large B-cell lymphoma |
| Investigator(s): | Srivastava G, Choi WL |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2012 |
| List of Research Outputs |
| Au Yeung K.H.R., Chen W.Y.W., Guo T., Wong K.Y., Shimizu N., Tsuchiyama J., Loong F., Kwong Y.L. and Srivastava G., Receptor-type tyrosine-protein phosphatase kappa promoter hypermethylation correlates with unfavorable prognosis in nasal NK/T-cell lymphoma patients treated with SMILE regimen, The 60th Autumn Annual Meeting of the Japanese Society of Pathology. 第60回日本病理学会秋期特別総会, Japan, 2014. |
| Chen W.Y.W., Guo T., Shen L., Wong K.Y., Tao Q., Choi W.L., Au Yeung K.H.R., Chan Y.P., Wong M.L.Y., Tang J.C.O., Liu W.P., Li G.D., Shimizu N., Loong F., Tse E.W.C., Kwong Y.L. and Srivastava G., Receptor-type tyrosine-protein phosphatase k directly targets STAT3 activation for tumor suppression in nasal NK/T-cell lymphoma, Blood. United States of America, The American Society of Hematology, 2015, 125(10): 1589-600. |
| Researcher : Sze MF |
| Project Title: | The characterizations of Ubiquitin-Conjugating Enzyme E2O (UBE2O) in mitotic checkpoint control via-interaction with MAD1 in hepatocellular carcinoma |
| Investigator(s): | Sze MF, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2014 |
| List of Research Outputs |
| Ma W., Sze M.F., Chan L.K., Lee M.F., Lee K.W., Wong C.C.L. and Ng I.O.L., RhoE/ROCK signaling modulates chemoresistance in HCC through IL6/JAK2/STAT3 pathways, New Horizons in Cancer Research Conference: Harnessing Breakthroughs – Targeting Cures. 2014. |
| Ma W., Sze M.F., Chan L.K., Lee M.F., Lee K.W., Wong C.C.L. and Ng I.O.L., Scholar-in-Training Award, New Horizons in Cancer Research Conference: Harnessing Breakthroughs – Targeting Cures (American Association for Cancer Research). 2014. |
| Ng I.O.L., Sze M.F. and Chu K.Y., Role of hepatitis B virus X protein in liver cancer, Hong Kong Med J. 2015, 21 Suppl 4: 27-30. |
| Researcher : Szeto E |
| List of Research Outputs |
| Cheung A.N.Y., Wong G.W., Chan K.K., Yang M.S., Tsang C.H., Ji S.L., Lo C.K., Szeto E., Wong E.S.Y. and Ngan H.Y.S., Integrated human papillomavirus analysis as an adjunct for triage of atypical cervical cytology, In: ANY Cheung, OG Wong, KKY Chan, MS Yang, CH Tsang, SL Ji, CK Lo, E Szeto, E Wong, HYS Ngan, Hong Kong Med J. 2014. |
| Researcher : TANG KH |
| List of Research Outputs |
| Lee K.W., Cheung C.H., Lu P., LAU Y.T., Ma S.K.Y., TANG K.H., Tong M., LO J. and Ng I.O.L., Blockade of CD47 mediated CTSS-PAR2 signaling provides a therapeutic target for hepatocellular carcinoma, Hepatology. 2014, 60: 179-191. |
| Researcher : TEY SK |
| List of Research Outputs |
| TEY S.K., TSE Y.T. and Yam J.W.P., Nuclear Met is overexpressed and promotes tumorigenesis and metastasis in hepatocellular carcinoma, 21st Hong Kong International Cancer Congress and 5th Annual Meeting Centre for Cancer Research. 2014. |
| TEY S.K., TSE Y.T., Ko F.C.F. and Yam J.W.P., Overexpression of nuclear met activates NF-KB signaling to promote tumorigenesis and metastasis in hepatocellullar carcinoma, 2015 American Association for Cancer Research Annual Meeting. 2015. |
| Researcher : TSE YT |
| List of Research Outputs |
| TEY S.K., TSE Y.T. and Yam J.W.P., Nuclear Met is overexpressed and promotes tumorigenesis and metastasis in hepatocellular carcinoma, 21st Hong Kong International Cancer Congress and 5th Annual Meeting Centre for Cancer Research. 2014. |
| TEY S.K., TSE Y.T., Ko F.C.F. and Yam J.W.P., Overexpression of nuclear met activates NF-KB signaling to promote tumorigenesis and metastasis in hepatocellullar carcinoma, 2015 American Association for Cancer Research Annual Meeting. 2015. |
| Researcher : Tam S |
| List of Research Outputs |
| Chan Y.H., Lau K.K., Yiu K.H., Li L.S.W., Tam S., Lam T.H., Lau C.P., Siu D.C.W., Cheung B.M.Y. and Tse H.F., Vascular protective effects of statin-related increase in serum 25-hydroxyvitamin D among high-risk cardiac patients, Journal of Cardiovascular Medicine. 2015, 16: 51-58. |
| Chan Y.H., Lau G.K.K., Yiu K.H., Li L.S.W., Tam S., Lam T.H., Lau C.P., Siu D.C.W., Cheung B.M.Y. and Tse H.F., Vascular protective effects of statin-related increase in serum 25-hydroxyvitamin D among high-risk cardiac patients, Journal of Cardiovascular Medicine (Hagerstown). 2015. |
| Cheung C.Y., Tam S., Lam C.W., Lie A.K.W. and Kwong Y.L., Allogeneic haematopoietic stem cell transplantation for erythropoietic protoporphyria: A cautionary note, Blood Cells, Molecules, and Diseases. 2015, 54: 266-267. |
| Chim J.C.S., Sim P.Y.J., Tam S., Tse E.W.C., Lie A.K.W. and Kwong Y.L., LDH is an adverse prognostic factor independent of ISS in transplant-eligible myeloma patients receiving bortezomib-based induction regimens, European Journal of Haematology. 2014, n/a-n/a. |
| Li R.H.W., Lam K.S.L., Tam S., Lee V.C.Y., Yeung T.W.Y., Cheung P.T., Yeung W.S.B., Ho P.C. and Ng E.H.Y., Screening for dysglycaemia by oral glucose tolerance test should be recommended in all women with polycystic ovary syndrome., Human Reproduction. 2015, 30(9): 2178-2183. |
| Woo Y.C., Cheung B.M.Y., Yeung C.Y., Lee C.H.P., Hui Y.L.E., Fong H.Y., Tso A.W.K., Tam S. and Lam K.S.L., Cardiometabolic risk profile of participants with prediabetes diagnosed by HbA1c criteria in an urban Hong Kong Chinese population over 40 years of age , Diabetic Medicine. 2015, n/a-n/a. |
| Researcher : Tang JCO |
| List of Research Outputs |
| Chen W.Y.W., Guo T., Shen L., Wong K.Y., Tao Q., Choi W.L., Au Yeung K.H.R., Chan Y.P., Wong M.L.Y., Tang J.C.O., Liu W.P., Li G.D., Shimizu N., Loong F., Tse E.W.C., Kwong Y.L. and Srivastava G., Receptor-type tyrosine-protein phosphatase k directly targets STAT3 activation for tumor suppression in nasal NK/T-cell lymphoma, Blood. United States of America, The American Society of Hematology, 2015, 125(10): 1589-600. |
| Researcher : Tin PC |
| List of Research Outputs |
| GAO X., Lin C., Kwan T.K., Lee V.H.F., Chan S.H., Sihoe D.L.A., Au S.K., Tin P.C., XIAO Z., Yam J.W.P., Wang J.J., Sham P.C. and Wong M.P., Application of whole exome sequencing in metachronous lung cancers evaluation, European Association for Cancer Research, Cambridge. 2015. |
| Wong M.P., Liu J., XIAO Z., Tin P.C., Wang S. and Kwan T.K., Calcium/calmodulin-dependent protein kinase II alpha (CaMK2A) regulates the tumor initiating cell phenotype through SOX2 expression and modulates treatment response to anti-cancer drugs in lung adenocarcinoma. , Annual Scientific Meeting of the American Association for Cancer Research, Philadelphia. 2015. |
| Researcher : Tsang FH |
| Project Title: | Functional characterization of Chromobox protein homolog 1 (CBX1) and delineation of its regulation by micro-RNA in hepatocellular carcinoma |
| Investigator(s): | Tsang FH, Wong CM |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2015 |
| Project Title: | Long Noncoding RNAs: From Evolution to Function ; Oncogenic long noncoding RNA HOTTIP is negatively regulated by tumor suppressive microRNA-125b in hepatocellular carcinoma |
| Investigator(s): | Tsang FH |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2015 |
| Completion Date: | 03/2015 |
| List of Research Outputs |
| Tsang F.H., Au L.K.S., Fan N.Y., Lee M.F., Wong C.C.L., Ng I.O.L. and Wong C.M., HOTTIP, an oncogenic long non-coding RNA, is frequently up-regulated in hepatocellular carcinoma and is negatively regulated by tumor suppressive microRNA miR-125b, Liver International. 2015, 35: 1597. |
| Wong C.C.L., Tse P.W., Huang Y., Zhu Y., CHIU K.C., LAI K.H., Au L.K.S., Kai A.K.L., Lee M.F., WEI L., Tsang F.H., Lo C.L.R., Shi J., Zheng Y., Wong C.M. and Ng I.O.L., Lysyl Oxidase-like 2 Is Critical To Tumor Microenvironment And Metastatic Niche Formation In Hepatocellular Carcinoma, In: Snorry Thorgeirsen, Hepatology. 2014. |
| Wong C.C.L., Au L.K.S., Tse P.W., Xu M., LAI K.H., CHIU K.C., WEI L., Fan N.Y., Tsang F.H., Lo C.L.R., Wong C.M. and Ng I.O.L., Switching of pyruvate kinase isoform L to M2 promotes metabolic reprogramming in hepatocarcinogenesis, PLos One. 2014. |
| Wong C.M., WEI L., Au L.K.S., Fan N.Y., Zhou Y., Tsang F.H., Lee M.F., He X., Shi J., Wong C.C.L. and Ng I.O.L., miR-200b/200c/429 subfamily negatively regulates Rho/ROCK signaling pathway and suppresses HCC metastasis, Oncotarget . 2015, 6: 13658. |
| Researcher : Tse PW |
| List of Research Outputs |
| Wong C.C.L., Tse P.W., Huang Y., Zhu Y., CHIU K.C., LAI K.H., Au L.K.S., Kai A.K.L., Lee M.F., WEI L., Tsang F.H., Lo C.L.R., Shi J., Zheng Y., Wong C.M. and Ng I.O.L., Lysyl Oxidase-like 2 Is Critical To Tumor Microenvironment And Metastatic Niche Formation In Hepatocellular Carcinoma, In: Snorry Thorgeirsen, Hepatology. 2014. |
| Wong C.C.L., Au L.K.S., Tse P.W., Xu M., LAI K.H., CHIU K.C., WEI L., Fan N.Y., Tsang F.H., Lo C.L.R., Wong C.M. and Ng I.O.L., Switching of pyruvate kinase isoform L to M2 promotes metabolic reprogramming in hepatocarcinogenesis, PLos One. 2014. |
| Researcher : Tsun OKL |
| List of Research Outputs |
| Kwok A.L., Wong G.W., Wong E.S.Y., Tsun O.K.L., Chan K.K. and Cheung A.N.Y., Caution over use of ES2 as a model of ovarian clear cell carcinoma., J Clin Pathol . 2014, 67: 921-2. |
| Wong K.W., Ip P.C.P., Tsun O.K.L., Wong E.S.Y., Cheung A.N.Y. and Wong G.W., Potential Targets in miRNA 143 in Cervical cancers, 21st Hong Kong International Cancer Congress. 2014. |
| Researcher : WEI L |
| List of Research Outputs |
| Wong C.C.L., Tse P.W., Huang Y., Zhu Y., CHIU K.C., LAI K.H., Au L.K.S., Kai A.K.L., Lee M.F., WEI L., Tsang F.H., Lo C.L.R., Shi J., Zheng Y., Wong C.M. and Ng I.O.L., Lysyl Oxidase-like 2 Is Critical To Tumor Microenvironment And Metastatic Niche Formation In Hepatocellular Carcinoma, In: Snorry Thorgeirsen, Hepatology. 2014. |
| Wong C.C.L., Au L.K.S., Tse P.W., Xu M., LAI K.H., CHIU K.C., WEI L., Fan N.Y., Tsang F.H., Lo C.L.R., Wong C.M. and Ng I.O.L., Switching of pyruvate kinase isoform L to M2 promotes metabolic reprogramming in hepatocarcinogenesis, PLos One. 2014. |
| Wong C.M., WEI L., Au L.K.S., Fan N.Y., Zhou Y., Tsang F.H., Lee M.F., He X., Shi J., Wong C.C.L. and Ng I.O.L., miR-200b/200c/429 subfamily negatively regulates Rho/ROCK signaling pathway and suppresses HCC metastasis, Oncotarget . 2015, 6: 13658. |
| Researcher : WONG YSS |
| List of Research Outputs |
| Mao X., WONG Y.S.S., Ko F.C.F. and Yam J.W.P., Upregulation of S100P by caveolin-1 drives tumorigenesis and metastasis in hepatocellular carcinoma under hypoxic stress, 2015 American Association for Cancer Research Annual Meeting. 2015. |
| Researcher : Wan TSK |
| List of Research Outputs |
| Lam C.L.D., Luo S.Y., Deng W., Kwan S.H., Rodriguez-Canales J., Cheung A., Cheng G.H.W., Lin C.H., Wistuba I.I., Sham P.C., Wan T.S.K. and Tsao G.S.W., Oncogenic mutation profiling in new lung cancer and mesothelioma cell lines, OncoTargets and Therapy. 2015, 8: 195-209. |
| Ng H.Y., Wan T.S.K., So J.C.C. and Chim J.C.S., Epigenetic inactivation of DAPK1, p14ARF, mir-34a and -34b/c in acute promyelocytic leukaemia, Journal of Clinical Pathology. 2014, 67: 626-631. |
| Researcher : Wong CCL |
| Project Title: | The roles and regulations of pyruvate kinase 2 (PKM2) in hepatocellular carcinoma development |
| Investigator(s): | Wong CCL |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 09/2013 |
| Project Title: | Hepatitis B virus infection promotes hepatocellular carcinoma through HIF-lα/LOXL2 pathway |
| Investigator(s): | Wong CCL, Ng IOL, Sze MF |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 12/2013 |
| Project Title: | Role of lysyl oxidase-like 2 (LOXL2) in the progression and metastasis of liver cancer |
| Investigator(s): | Wong CCL, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2013 |
| Project Title: | Clinical relevance and roles of hypoxia-induced NDUFA4L2 in hepatocellular carcinoma progression |
| Investigator(s): | Wong CCL, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Clinical relevance and roles of hypoxia-induced NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 (NDUFA4L2) in hepatocellar carcinoma progression |
| Investigator(s): | Wong CCL, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Keystone Symposia Conference: Integrating Metabolism and Tumor Biology ; Pyruvate kinase M2 promoted aerobic glycolysis and growth of hepatocellular carcinoma |
| Investigator(s): | Wong CCL |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 01/2015 |
| Completion Date: | 01/2015 |
| Project Title: | The molecular mechanims of hypoxia-induced myeloid-derived suppressor cell (MDSC) recruitment in liver cancer |
| Investigator(s): | Wong CCL, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Leung O.N., Wong C.C.L., Fan D.N., Kai A.K.L., Tung E.K., Xu M., Ng I.O.L. and Lo C.L.R., PIM1 regulates glycolysis and promotes tumor progression in hepatocellular carcinoma., Oncotarget. 2015. |
| Lo C.L.R., Leung O.N., Wong C.C.L., Kai A.K.L. and Ng I.O.L., Pim1 Is Upregulated By Hypoxia In Hepatocellular Carcinoma And Promotes Tumor Progression , International Liver Cancer Association Annual Conference 2014. |
| Ma W., Sze M.F., Chan L.K., Lee M.F., Lee K.W., Wong C.C.L. and Ng I.O.L., RhoE/ROCK signaling modulates chemoresistance in HCC through IL6/JAK2/STAT3 pathways, New Horizons in Cancer Research Conference: Harnessing Breakthroughs – Targeting Cures. 2014. |
| Ma W., Sze M.F., Chan L.K., Lee M.F., Lee K.W., Wong C.C.L. and Ng I.O.L., Scholar-in-Training Award, New Horizons in Cancer Research Conference: Harnessing Breakthroughs – Targeting Cures (American Association for Cancer Research). 2014. |
| Tsang F.H., Au L.K.S., Fan N.Y., Lee M.F., Wong C.C.L., Ng I.O.L. and Wong C.M., HOTTIP, an oncogenic long non-coding RNA, is frequently up-regulated in hepatocellular carcinoma and is negatively regulated by tumor suppressive microRNA miR-125b, Liver International. 2015, 35: 1597. |
| Wong C.C.L., Tse P.W., Huang Y., Zhu Y., CHIU K.C., LAI K.H., Au L.K.S., Kai A.K.L., Lee M.F., WEI L., Tsang F.H., Lo C.L.R., Shi J., Zheng Y., Wong C.M. and Ng I.O.L., Lysyl Oxidase-like 2 Is Critical To Tumor Microenvironment And Metastatic Niche Formation In Hepatocellular Carcinoma, In: Snorry Thorgeirsen, Hepatology. 2014. |
| Wong C.C.L., Lysyl oxidase-like 2 (LOXL2) is critical to hepatocellular carcinoma metastasis, 兩地三方會議/ The University of Hong Kong, Eastern Hepatobiliary Hospital, Shanghai Cancer Institute. 2014. |
| Wong C.C.L. and Ng I.O.L., Pyruvate Kinase M2 Promoted Aerobic Glycolysis And Growth Of Hepatocellular Carcinoma, Keystone Symposia Conference - Integrating Metabolism And Tumor Biology. 2015. |
| Wong C.C.L., Remodeling Of The Tumor Stroma Contributes To Hepatocellular Carcinoma Progression. , State Key Laboratory For Liver Research Symposium: From Bench Research To Patient Care. . 2014. |
| Wong C.C.L., Au L.K.S., Tse P.W., Xu M., LAI K.H., CHIU K.C., WEI L., Fan N.Y., Tsang F.H., Lo C.L.R., Wong C.M. and Ng I.O.L., Switching of pyruvate kinase isoform L to M2 promotes metabolic reprogramming in hepatocarcinogenesis, PLos One. 2014. |
| Wong C.C.L., The Versatile Roles Of Hypoxia In Cancer Development., Departmental Seminar. Department Of Clinical Oncology, The University Of Hong Kong. 2014. |
| Wong C.M., WEI L., Au L.K.S., Fan N.Y., Zhou Y., Tsang F.H., Lee M.F., He X., Shi J., Wong C.C.L. and Ng I.O.L., miR-200b/200c/429 subfamily negatively regulates Rho/ROCK signaling pathway and suppresses HCC metastasis, Oncotarget . 2015, 6: 13658. |
| Researcher : Wong CL |
| Project Title: | The roles and regulations of pyruvate kinase 2 (PKM2) in hepatocellular carcinoma development |
| Investigator(s): | Wong CCL |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 09/2013 |
| Project Title: | Hepatitis B virus infection promotes hepatocellular carcinoma through HIF-lα/LOXL2 pathway |
| Investigator(s): | Wong CCL, Ng IOL, Sze MF |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 12/2013 |
| Project Title: | Role of lysyl oxidase-like 2 (LOXL2) in the progression and metastasis of liver cancer |
| Investigator(s): | Wong CCL, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2013 |
| Project Title: | Clinical relevance and roles of hypoxia-induced NDUFA4L2 in hepatocellular carcinoma progression |
| Investigator(s): | Wong CCL, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Clinical relevance and roles of hypoxia-induced NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 (NDUFA4L2) in hepatocellar carcinoma progression |
| Investigator(s): | Wong CCL, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Keystone Symposia Conference: Integrating Metabolism and Tumor Biology ; Pyruvate kinase M2 promoted aerobic glycolysis and growth of hepatocellular carcinoma |
| Investigator(s): | Wong CCL |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 01/2015 |
| Completion Date: | 01/2015 |
| Project Title: | The molecular mechanims of hypoxia-induced myeloid-derived suppressor cell (MDSC) recruitment in liver cancer |
| Investigator(s): | Wong CCL, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Researcher : Wong CM |
| Project Title: | Deregulation of SETDB1 and its functional roles in liver cancer |
| Investigator(s): | Wong CM |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Project Title: | Deregulation of HOTTIP long non-coding RNA in liver cancer |
| Investigator(s): | Wong CM, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2013 |
| Completion Date: | 06/2015 |
| Project Title: | Functional and pathological characterizations of chromatin remodeling protein HELLS in liver cancer |
| Investigator(s): | Wong CM, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | American Association for Cancer Research Annual meeting 2015; HOTTIP, an oncogenic long non-coding RNA, is frequently up-regulated in hepatocellular carcinoma and is negatively regulated by tumor suppressive microRNA miR-125b |
| Investigator(s): | Wong CM |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2015 |
| Completion Date: | 04/2015 |
| Project Title: | Expression and pathological roles of linc-CHD1L-1, a novel long non-coding RNA in liver cancer |
| Investigator(s): | Wong CM, Tsang FH |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Li L., Leung C. .W., DU Y., Wong C.M. and Pong P.W.T., Capping-Ligands-Induced Synthesis of Nonspherical Magnetite Nanoparticles for Hyperthermia and their Biocompatibility Study, IEEE International Magnetics Conference, Beijing, China, May, 2015, Paper No. EV-14. 2015. |
| Li L., Woo H. .K., Sun Y., Mak K. .Y., Leung C. .W., DU Y., Lai P.T., Wong C.M., Shi J. and Pong P.W.T., Influence of oxygen plasma treatment on nanogroove-prepatterned polydimethysiloxane (PDMS) in modulating cellular behavior, 2nd International Congress on Materials and Renewable Energy & Nanomaterials Symposia, Hong Kong, August, 2014, Paper No. MRE-298(a). 2014. |
| Tang H.M.V., Gao W., Chan C.P., Cheng Y., Chaudhary V., Deng J., Yuen K.S., Wong C.M., Ng I.O.L., Kok K.H., Zhou J. and Jin D., Requirement of CRTC1 coactivator for hepatitis B virus transcription, Nucleic Acids Res. 2014, 42(20): 12455-68. |
| Tsang F.H., Au L.K.S., Fan N.Y., Lee M.F., Wong C.C.L., Ng I.O.L. and Wong C.M., HOTTIP, an oncogenic long non-coding RNA, is frequently up-regulated in hepatocellular carcinoma and is negatively regulated by tumor suppressive microRNA miR-125b, Liver International. 2015, 35: 1597. |
| Wong C.C.L., Tse P.W., Huang Y., Zhu Y., CHIU K.C., LAI K.H., Au L.K.S., Kai A.K.L., Lee M.F., WEI L., Tsang F.H., Lo C.L.R., Shi J., Zheng Y., Wong C.M. and Ng I.O.L., Lysyl Oxidase-like 2 Is Critical To Tumor Microenvironment And Metastatic Niche Formation In Hepatocellular Carcinoma, In: Snorry Thorgeirsen, Hepatology. 2014. |
| Wong C.C.L., Au L.K.S., Tse P.W., Xu M., LAI K.H., CHIU K.C., WEI L., Fan N.Y., Tsang F.H., Lo C.L.R., Wong C.M. and Ng I.O.L., Switching of pyruvate kinase isoform L to M2 promotes metabolic reprogramming in hepatocarcinogenesis, PLos One. 2014. |
| Wong C.M., WEI L., Au L.K.S., Fan N.Y., Zhou Y., Tsang F.H., Lee M.F., He X., Shi J., Wong C.C.L. and Ng I.O.L., miR-200b/200c/429 subfamily negatively regulates Rho/ROCK signaling pathway and suppresses HCC metastasis, Oncotarget . 2015, 6: 13658. |
| ZHANG Y., Yang J., ZHANG J., Sun L., Hirankarn N., Pan H.F., Lau W.C.S., Chan T.M., Lee T.L., Leung A.M., Mok C.C., ZHANG L., WANG Y., Shen J.J., Wong S.N., Lee K.W., Ho M.H.K., Lee P.P.W., Chung B.H.Y., Chong C.Y., Wong R.W.S., Mok T.M.Y., Wong W.H.S., Tong K.L., Tse N.K.C., LI X.P., Avihingsanon Y., Rianthavorn P., SDeekajorndej T., Shotelersuk V., Suphapeetiporn K., Shotelersuk V., Ying S.K.Y., Fung S.K.S., Lai W.M., Wong C.M., Ng I.O.L., Sham P.C., Garcia-Barcelo M.M., Cherny S.S., Cui Y., Sham P.C., Yang S., Ye D.Q., Zhang X.J., Lau Y.L. and Yang W., Genome-wide search followed by replication reveals genetic interaction of CD80 and ALOX5AP associated with systemic lupus erythematosus in Asian populations, Annuals of Rheumatic Diseases. 2015. |
| Zhang Y., ZHANG J., Yang J., WANG Y., ZHANG L., Zuo X., Sun L., Pan H.F., Hirankarn N., WANG T., CHEN R., Ying D., Shen J.J., Lee T.L., Lau W.C.S., Chan D.T.M., Leung A.M.H., Mok C.C., Wong S.N., Lee K.W., Ho M.H.K., Lee P.P.W., Chung B.H.Y., Chong C.Y., Wong R.W.S., Mok T.M.Y., Wong W.H.S., Tong K.L., Tse N.K.C., Li X.P., Avihingsanon Y., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Shotelersuk V., Ying S.K.Y., Fung S.K.S., Lai W.M., Wong C.M., Ng I.O.L., Garcia-Barcelo M.M., Cherny S.S., Tam P.K.H., Sham P.C., Yang S., Ye D.Q., Cui Y., Zhang X.J., Lau Y.L. and Yang W., Meta-analysis of GWAS on two Chinese populations followed by replication identifies novel genetic variants on the X chromosome associated with systemic lupus erythematosus, Human Molecular Genetics. 2015, 24(1): 274-284. |
| Zhang Y., Wang Y., Yang J., ZHANG J., Sun L., Hirankarn N., Pan C.F., Lau W.C.S., Chan T.M., Lee T.L., Leung A.M.H., Mok C.C., ZHANG L., SHEN J., Wong S.N., Lee K.W., Ho M.H.K., Lee P.P.W., Chung B.H.Y., Chong C.Y., Wong R.W.S., Mok T.M.Y., Wong W.H.S., Tong K.L., Tse N.K., Li X.P., Avihingsanon Y., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Shotelersuk V., Ying S.K., Fung S.K., Lai W.M., Wong C.M., Ng I.O.L., Garcia-Barcelo M.M., Cherny S.S., Tam P.K.H., Sham P.C., Yang S., Ye D.Q., Cui Y., Zhang X.J., Yang W. and Lau Y.L., Meta-analysis of two Chinese populations identifies an autoimmune disease risk allele in 22q11.21 as associated with systemic lupus erythematosus, Arthritis Research & Therapy. 2015, 17: 67. |
| Researcher : Wong ESY |
| List of Research Outputs |
| Cheung A.N.Y., Wong G.W., Chan K.K., Yang M.S., Tsang C.H., Ji S.L., Lo C.K., Szeto E., Wong E.S.Y. and Ngan H.Y.S., Integrated human papillomavirus analysis as an adjunct for triage of atypical cervical cytology, In: ANY Cheung, OG Wong, KKY Chan, MS Yang, CH Tsang, SL Ji, CK Lo, E Szeto, E Wong, HYS Ngan, Hong Kong Med J. 2014. |
| Kwok A.L., Wong G.W., Wong E.S.Y., Tsun O.K.L., Chan K.K. and Cheung A.N.Y., Caution over use of ES2 as a model of ovarian clear cell carcinoma., J Clin Pathol . 2014, 67: 921-2. |
| Mak C.Y., Wong G.W., Siu K.Y., Wong E.S.Y., Ngan W.Y., Wong R.W., Chan K.K., Ngan H.Y.S. and Cheung A.N.Y., FBI-1 Is Overexpressed in Gestational Trophoblastic Disease and Promotes Tumor Growth and Cell Aggressiveness of Choriocarcinoma via PI3K/Akt Signaling., Am J Pathol. 2015, 185(7): 2038-48. |
| Wong K.W., Ip P.C.P., Tsun O.K.L., Wong E.S.Y., Cheung A.N.Y. and Wong G.W., Potential Targets in miRNA 143 in Cervical cancers, 21st Hong Kong International Cancer Congress. 2014. |
| Zhao F., Siu K.Y., Jiang L.L., Tam K.F., Ngan H.Y.S., Le X.F., Wong G.W., Wong E.S.Y., Gomes A.R., Bella L., Khongkow P., Lam E.W. and Cheung A.N.Y., Overexpression of Forkhead Box Protein M1 (FOXM1) in Ovarian Cancer Correlates with Poor Patient Survival and Contributes to Paclitaxel Resistance, PLoS ONE. 2014, 9: e113478. |
| Researcher : Wong GW |
| Project Title: | Cellular functions and potential clinical application of miR-143 in cervical cancer |
| Investigator(s): | Wong GW, Cheung ANY, Ngan HYS |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 01/2014 |
| Project Title: | Identification of HNF-1β direct targets in ovarian clear cell carcinoma |
| Investigator(s): | Wong GW, Cheung ANY |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 04/2015 |
| List of Research Outputs |
| Cheung A.N.Y., Wong G.W., Chan K.K., Yang M.S., Tsang C.H., Ji S.L., Lo C.K., Szeto E., Wong E.S.Y. and Ngan H.Y.S., Integrated human papillomavirus analysis as an adjunct for triage of atypical cervical cytology, In: ANY Cheung, OG Wong, KKY Chan, MS Yang, CH Tsang, SL Ji, CK Lo, E Szeto, E Wong, HYS Ngan, Hong Kong Med J. 2014. |
| Ho J., DU Y., Wong G.W., Siu K.Y., Chan K.K.L. and Cheung A.N.Y., Downregulation of the Gli Transcription Factors Regulator Kif7 Facilitates Cell Survival and Migration of Choriocarcinoma Cells, PLoS ONE. 2014, 9: e108248. |
| Kwok A.L., Wong G.W., Wong E.S.Y., Tsun O.K.L., Chan K.K. and Cheung A.N.Y., Caution over use of ES2 as a model of ovarian clear cell carcinoma., J Clin Pathol . 2014, 67: 921-2. |
| Mak C.Y., Wong G.W., Siu K.Y., Wong E.S.Y., Ngan W.Y., Wong R.W., Chan K.K., Ngan H.Y.S. and Cheung A.N.Y., FBI-1 Is Overexpressed in Gestational Trophoblastic Disease and Promotes Tumor Growth and Cell Aggressiveness of Choriocarcinoma via PI3K/Akt Signaling., Am J Pathol. 2015, 185(7): 2038-48. |
| Wong K.W., Ip P.C.P., Tsun O.K.L., Wong E.S.Y., Cheung A.N.Y. and Wong G.W., Potential Targets in miRNA 143 in Cervical cancers, 21st Hong Kong International Cancer Congress. 2014. |
| Zhao F., Siu K.Y., Jiang L.L., Tam K.F., Ngan H.Y.S., Le X.F., Wong G.W., Wong E.S.Y., Gomes A.R., Bella L., Khongkow P., Lam E.W. and Cheung A.N.Y., Overexpression of Forkhead Box Protein M1 (FOXM1) in Ovarian Cancer Correlates with Poor Patient Survival and Contributes to Paclitaxel Resistance, PLoS ONE. 2014, 9: e113478. |
| Researcher : Wong KF |
| List of Research Outputs |
| So J.C.C., Chan A., Chung L.P., Siu L., Wong W.S. and Wong K.F., A comparison of high resolution melting, allele-specific priming and Sanger sequencing for the detection of BRAFV600E mutation in hairy cell leukaemia from different haematological specimens, Pathology. 2014, 46: 533-537. |
| Researcher : Wong KW |
| List of Research Outputs |
| Wong K.W., Ip P.C.P., Tsun O.K.L., Wong E.S.Y., Cheung A.N.Y. and Wong G.W., Potential Targets in miRNA 143 in Cervical cancers, 21st Hong Kong International Cancer Congress. 2014. |
| Researcher : Wong KY |
| List of Research Outputs |
| Au Yeung K.H.R., Chen W.Y.W., Guo T., Wong K.Y., Shimizu N., Tsuchiyama J., Loong F., Kwong Y.L. and Srivastava G., Receptor-type tyrosine-protein phosphatase kappa promoter hypermethylation correlates with unfavorable prognosis in nasal NK/T-cell lymphoma patients treated with SMILE regimen, The 60th Autumn Annual Meeting of the Japanese Society of Pathology. 第60回日本病理学会秋期特別総会, Japan, 2014. |
| Chen W.Y.W., Guo T., Shen L., Wong K.Y., Tao Q., Choi W.L., Au Yeung K.H.R., Chan Y.P., Wong M.L.Y., Tang J.C.O., Liu W.P., Li G.D., Shimizu N., Loong F., Tse E.W.C., Kwong Y.L. and Srivastava G., Receptor-type tyrosine-protein phosphatase k directly targets STAT3 activation for tumor suppression in nasal NK/T-cell lymphoma, Blood. United States of America, The American Society of Hematology, 2015, 125(10): 1589-600. |
| Researcher : Wong M.P. |
| Project Title: | Mutational Analysis of Epidermal Growth Factor Receptor in Non-Small Cell Lung Cancer |
| Investigator(s): | Wong MP, Chua DTT |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2005 |
| Project Title: | p38 MAPK in human lung cancers and its involvement in treatment resistance to tyrosine kinase inhibitors |
| Investigator(s): | Wong MP, Leung LH |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 02/2011 |
| Project Title: | Investigation of tumor-propagating cells and stemness/differentiation axis pathways in non-small cell lung cancers |
| Investigator(s): | Wong MP, Sham MH, Wang JJ |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2011 |
| Project Title: | The role of non-canonical Wnt signaling in cancer cell survival and drug resistance in lung cancer |
| Investigator(s): | Wong MP |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2013 |
| Project Title: | The role of Ca2+/calmodulin-dependent protein kinase II (CaMKII) in tumour initiating cells (TIC) regulation in non-small cell lung cancer |
| Investigator(s): | Wong MP, Liu J |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2014 |
| Project Title: | Identification of cancer metastasis and drug resistance pathways through comparison of primary and metastatic lung adenocarcinomas by next generation sequencing analysis |
| Investigator(s): | Wong MP, Lee VHF, Sihoe DLA, Wang JJ, Sham PC |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2014 |
| Project Title: | The role and mechanisms of tumor initiating cells regulation by nuclear factor of activated T-cells (NFAT) pathway in non-small cell lung cancer |
| Investigator(s): | Wong MP, Wang JJ |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2014 |
| Project Title: | Cancer Genomics; Application of whole exome sequencing in metachronous lung cancer evaluation |
| Investigator(s): | Wong MP |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2015 |
| Project Title: | Regulation of SOX2 expression by NFATc2 in lung cancer |
| Investigator(s): | Wong MP |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Researcher : Wong MLY |
| List of Research Outputs |
| Chen W.Y.W., Guo T., Shen L., Wong K.Y., Tao Q., Choi W.L., Au Yeung K.H.R., Chan Y.P., Wong M.L.Y., Tang J.C.O., Liu W.P., Li G.D., Shimizu N., Loong F., Tse E.W.C., Kwong Y.L. and Srivastava G., Receptor-type tyrosine-protein phosphatase k directly targets STAT3 activation for tumor suppression in nasal NK/T-cell lymphoma, Blood. United States of America, The American Society of Hematology, 2015, 125(10): 1589-600. |
| Researcher : Wong MP |
| Project Title: | Mutational Analysis of Epidermal Growth Factor Receptor in Non-Small Cell Lung Cancer |
| Investigator(s): | Wong MP, Chua DTT |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2005 |
| Project Title: | p38 MAPK in human lung cancers and its involvement in treatment resistance to tyrosine kinase inhibitors |
| Investigator(s): | Wong MP, Leung LH |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 02/2011 |
| Project Title: | Investigation of tumor-propagating cells and stemness/differentiation axis pathways in non-small cell lung cancers |
| Investigator(s): | Wong MP, Sham MH, Wang JJ |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2011 |
| Project Title: | The role of non-canonical Wnt signaling in cancer cell survival and drug resistance in lung cancer |
| Investigator(s): | Wong MP |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2013 |
| Project Title: | The role of Ca2+/calmodulin-dependent protein kinase II (CaMKII) in tumour initiating cells (TIC) regulation in non-small cell lung cancer |
| Investigator(s): | Wong MP, Liu J |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2014 |
| Project Title: | Identification of cancer metastasis and drug resistance pathways through comparison of primary and metastatic lung adenocarcinomas by next generation sequencing analysis |
| Investigator(s): | Wong MP, Lee VHF, Sihoe DLA, Wang JJ, Sham PC |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2014 |
| Project Title: | The role and mechanisms of tumor initiating cells regulation by nuclear factor of activated T-cells (NFAT) pathway in non-small cell lung cancer |
| Investigator(s): | Wong MP, Wang JJ |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2014 |
| Project Title: | Cancer Genomics; Application of whole exome sequencing in metachronous lung cancer evaluation |
| Investigator(s): | Wong MP |
| Department: | Pathology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2015 |
| Project Title: | Regulation of SOX2 expression by NFATc2 in lung cancer |
| Investigator(s): | Wong MP |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2015 |
| List of Research Outputs |
| GAO X., Lin C., Kwan T.K., Lee V.H.F., Chan S.H., Sihoe D.L.A., Au S.K., Tin P.C., XIAO Z., Yam J.W.P., Wang J.J., Sham P.C. and Wong M.P., Application of whole exome sequencing in metachronous lung cancers evaluation, European Association for Cancer Research, Cambridge. 2015. |
| Hosgood H.D., Song M., Hsiung C.A., Yin Z., Shu X.O., Wang Z., Chatterjee N., Zheng W., Caporaso N., Burdette L., Yeager M., Berndt S.I., Landi M.T., Chen C., Chang G., Hsiao C., Tsai Y., Chien L., Chen K., Huang M., Su W., Chen Y., Chen C., Yang T., Wang C., Hung J., Lin C., Perng R., Chen C., Chen K., Li Y., Yu C., Chen Y., Chen Y., Tsai F., Kim C., Seow W.J., Bassig B.A., Wu W., Guan P., He Q., Gao Y., Cai Q., Chow W., Xiang Y., Lin D., Wu C., Wu Y., Shin M., Hong Y., Matsuo K., Chen K., Wong M.P., Lu D., Jin L., Wang J., Seow A., Wu T., Shen H., Fraumeni J.F., Yang P., Chang I., Zhou B., Chanock S.J., Rothman N. and Lan Q., Interactions between household air pollution and GWAS-identified lung cancer susceptibility markers in the Female Lung Cancer Consortium in Asia (FLCCA), Human Genetics. 2015, 134: 333-341. |
| Lee E.Y.P., Khong P.L., Lee V.H.F. and Wong M.P., Baseline FDG-PET/CT parameters may assist in predicting overall survival in TKI-treated stage IV lung adenocarcinoma., IASLC Asia Pacific Lung Cancer Conference, Kuala Lumpur, Malaysia. 2014. |
| Lee E.Y.P., Khong P.L., Lee V.H.F., Qian W., Yu X. and Wong M.P., Metabolic Phenotype of Stage IV Lung Adenocarcinoma: relationship with epidermal growth factor receptor mutation, Clinical Nuclear Medicine. 2015, 40: e190-e195. |
| Lee E.Y.P., Khong P.L., Lee V.H.F., Qian W., Yu X. and Wong M.P., Metabolic phenotype of metastasis in stage IV lung adenocarcinoma assists in predicting EGFR mutations., 15th AOCR. 2014. |
| Li M.J., Liu Z., Wang P., Wong M.P., Yeager M., Sham P.C., Chanock S.J., Xia Z. and Wang J.J., A Comprehensive Database for GWAS ¬identified Human Genetic Variants: An Update of GWASdb, The 2015 American College of Medical Genetics and Genomics (ACMG) Annual Clinical Genetics Meeting, Salt Lake City, US, 24-28 Mar 2015.. 2015. |
| Machiela M.J., Zhou W., Sampson J.N., Dean M.C., Jacobs K.B., Black A., Brinton L.A., Chang I., Chen C., Chen C., Chen K., Cook L.S., Crous Bou M., De Vivo I., Doherty J., Friedenreich C.M., Gaudet M.M., Haiman C.A., Hankinson S.E., Hartge P., Henderson B.E., Hong Y., Hosgood H.D., Hsiung C.A., HU W., Hunter D.J., Jessop L., Kim H.N., Kim Y.H., Kim Y.T., Klein R., Kraft P., Lan Q., Lin D., Liu J., Le Marchand L., Liang X., Lissowska J., Lu L., Magliocco A.M., Matsuo K., Olson S.H., Orlow I., Park J.Y., Pooler L., Prescott J., Rastogi R., Risch H.A., Schumacher F., Seow A., Setiawan V.W., Shen H., Sheng X., Shin M., Shu X., VanDen Berg D., Wang J., Wentzensen N., Wong M.P., Wu C., Wu T., Wu Y., Xia L., Yang H.P., Yang P., Zheng W., Zhou B., Abnet C.C., Albanes D., Aldrich M.C., Amos C., Amundadottir L.T., Berndt S.I., Blot W.J., Bock C.H., Bracci P.M., Burdett L., Buring J.E., Butler M.A., Carreón T., Chatterjee N., Chung C.C., Cook M.B., Cullen M., Davis F.G., Ding T., Duell E.J., Epstein C.G., Fan J., Figueroa J.D., Fraumeni J.F., Freedman N.D., Fuchs C.S., Gao Y., Gapstur S.M., Patiño-Garcia A., Garcia-Closas M., Gaziano J.M., Giles G.G., Gillanders E.M., Giovannucci E.L., Goldin L., Goldstein A.M., Greene M.H., Hallmans G., Harris C.C., Henriksson R., Holly E.A., Hoover R.N., Hu N., Hutchinson A., Jenab M., Johansen C., Khaw K., Koh W., Kolonel L.N., Kooperberg C., Krogh V., Kurtz R.C., LaCroix A., Landgren A., Landi M.T., Li D., Liao L.M., Malats N., McGlynn K.A., McNeill L.H., McWilliams R.R., Melin B.S., Mirabello L., Peplonska B., Peters U., Petersen G.M., Prokunina-Olsson L., Purdue M., Qiao Y., Rabe K.G., Rajaraman P., Real F.X., Riboli E., Rodríguez-Santiago B., Rothman N., Ruder A.M., Savage S.A., Schwartz A.G., Schwartz K.L., Sesso H.D., Severi G., Silverman D.T., Spitz M.R., Stevens V.L., Stolzenberg-Solomon R., Stram D., Tang Z., Taylor P.R., Teras L.R., Tobias G.S., Viswanathan K., Wacholder S., Wang Z., Weinstein S.J., Wheeler W., White E., Wiencke J.K., Wolpin B.M., Wu X., Wunder J.S., Yu K., Zanetti K.A., Zeleniuch-Jacquotte A., Ziegler R.G., de Andrade M., Barnes K.C., Beaty T.H., Bierut L.J., Desch K.C., Doheny K.F., Feenstra B., Ginsburg D., Heit J.A., Kang C.A., Laurie C.A., Li J.Z., Lowe W.L., Marazita M.L., Melbye M., Mirel D.B., Murray J.C., Nelson S.C., Pasquale L.R., Rice K., Wiggs J.L., Wise A., Tucker M., Pérez-Jurado L.A., Laurie C.C., Caporaso N.E., Yeager M. and Chanock S.J., Characterization of Large Structural Genetic Mosaicism in Human Autosomes, The American Journal of Human Genetics. 2015, 96: 487-497. |
| Wang D.D., Ma L., Wong M.P., Lee V.H.F. and Yan H., Contribution of EGFR and ErbB-3 Heterodimerization to the EGFR Mutation-Induced Gefitinib- and Erlotinib-Resistance in Non-Small-Cell Lung Carcinoma Treatments, PLOS ONE. 2015, 10: e0128360. |
| Wang Z., Zhu B., Zhang M., Parikh H., Wong M.P., Xu J. and Wang J.J., Imputation and subset based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33., In: Z. Wang, B. Zhu, M. Zhang, M. P. Wong, J. Wang, J, Xu and 205 editors, Hum Mol Genet . 2014, 23(24): 6616-33. |
| Wong M.P., Liu J., XIAO Z., Tin P.C., Wang S. and Kwan T.K., Calcium/calmodulin-dependent protein kinase II alpha (CaMK2A) regulates the tumor initiating cell phenotype through SOX2 expression and modulates treatment response to anti-cancer drugs in lung adenocarcinoma. , Annual Scientific Meeting of the American Association for Cancer Research, Philadelphia. 2015. |
| YALAMANCHILI H.K., LI Z., WANG P., Wong M.P., Yao J.J. and Wang J.J., SpliceNet: recovering splicing isoform-specific differential gene networks from RNA-Seq data of normal and diseased samples, Nucleic Acids Research. 2014, 42 (15): e121. |
| Researcher : XIAO Z |
| List of Research Outputs |
| GAO X., Lin C., Kwan T.K., Lee V.H.F., Chan S.H., Sihoe D.L.A., Au S.K., Tin P.C., XIAO Z., Yam J.W.P., Wang J.J., Sham P.C. and Wong M.P., Application of whole exome sequencing in metachronous lung cancers evaluation, European Association for Cancer Research, Cambridge. 2015. |
| Wong M.P., Liu J., XIAO Z., Tin P.C., Wang S. and Kwan T.K., Calcium/calmodulin-dependent protein kinase II alpha (CaMK2A) regulates the tumor initiating cell phenotype through SOX2 expression and modulates treatment response to anti-cancer drugs in lung adenocarcinoma. , Annual Scientific Meeting of the American Association for Cancer Research, Philadelphia. 2015. |
| Researcher : Xu M |
| List of Research Outputs |
| Leung O.N., Wong C.C.L., Fan D.N., Kai A.K.L., Tung E.K., Xu M., Ng I.O.L. and Lo C.L.R., PIM1 regulates glycolysis and promotes tumor progression in hepatocellular carcinoma., Oncotarget. 2015. |
| Wong C.C.L., Au L.K.S., Tse P.W., Xu M., LAI K.H., CHIU K.C., WEI L., Fan N.Y., Tsang F.H., Lo C.L.R., Wong C.M. and Ng I.O.L., Switching of pyruvate kinase isoform L to M2 promotes metabolic reprogramming in hepatocarcinogenesis, PLos One. 2014. |
| Researcher : Yam JWP |
| Project Title: | Outstanding Young Researcher Award 2008-2009 |
| Investigator(s): | Yam JWP |
| Department: | Pathology |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 12/2009 |
| Project Title: | Study of COOH-terminal truncated HBx protein-activated oncogenic caveolin-1 in hepatocellular carcinoma |
| Investigator(s): | Yam JWP, Guan X |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2013 |
| Project Title: | Role of caveolim-1 in hepatitis B virus-induced hepatocarcinogenesis |
| Investigator(s): | Yam JWP, Guan X |
| Department: | Pathology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 11/2013 |
| Project Title: | Clinical relevance and functions of nuclear Met in hepatocellular carcinoma metastasis |
| Investigator(s): | Yam JWP, Wong AST |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2013 |
| Project Title: | Development of combined therapeutic approach of Cav1 silencing with TACE for the treatment of liver malignancy |
| Investigator(s): | Yam JWP |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 06/2014 |
| Completion Date: | 05/2015 |
| Project Title: | The functional role of phospho-DLC1S549-mediatd galectin-1 in liver cancer |
| Investigator(s): | Yam JWP, Ching YP |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Functional role and clinical significance of galectin-1 in liver cancer |
| Investigator(s): | Yam JWP, Ching YP |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Molecular interaction of Cav1 and S100P in liver cancer metastasis |
| Investigator(s): | Yam JWP |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2015 |
| List of Research Outputs |
| CAI C., Shi L., Liu V.W.S., TANG W.M., LIU J., Leung T.H.Y., Chan K.K.L., Yam J.W.P., Yao K.M., Ngan H.Y.S. and Chan D.W., Elevated TAK1 augments tumor growth and metastatic capacities of ovarian cancer cells through activation of NF-κB signaling , 2014. |
| CAI C., SHI L., Liu V.W.S., TANG W.M., LIU J., Leung T.H.Y., Chan K.K.L., Yam J.W.P., Yao K.M., Ngan H.Y.S. and Chan D.W., Elevated TAK1 augments tumor growth and metastatic capacities of ovarian cancer cells through activation of NF-κB signaling, Oncotarget. USA, Impact Journals, LLC., 2014, 5: 7549-62. |
| GAO X., Lin C., Kwan T.K., Lee V.H.F., Chan S.H., Sihoe D.L.A., Au S.K., Tin P.C., XIAO Z., Yam J.W.P., Wang J.J., Sham P.C. and Wong M.P., Application of whole exome sequencing in metachronous lung cancers evaluation, European Association for Cancer Research, Cambridge. 2015. |
| Mao X., WONG Y.S.S., Ko F.C.F. and Yam J.W.P., Upregulation of S100P by caveolin-1 drives tumorigenesis and metastasis in hepatocellular carcinoma under hypoxic stress, 2015 American Association for Cancer Research Annual Meeting. 2015. |
| TEY S.K., TSE Y.T. and Yam J.W.P., Nuclear Met is overexpressed and promotes tumorigenesis and metastasis in hepatocellular carcinoma, 21st Hong Kong International Cancer Congress and 5th Annual Meeting Centre for Cancer Research. 2014. |
| TEY S.K., TSE Y.T., Ko F.C.F. and Yam J.W.P., Overexpression of nuclear met activates NF-KB signaling to promote tumorigenesis and metastasis in hepatocellullar carcinoma, 2015 American Association for Cancer Research Annual Meeting. 2015. |
| Tong M., Fung T.M., Luk T.C.S., Ng K.Y., Lee K.W., Lin C., Yam J.W.P., Chan K.W., Ng F., Zheng B., Yuan Y.F., Xie D., Lo C.M., Man K., Guan X. and Ma S.K.Y., ANXA3/JNK Signaling Promotes Self-Renewal and Tumor Growth, and Its Blockade Provides a Therapeutic Target for Hepatocellular Carcinoma, Stem Cell Reports. 2015. |
| Yam J.W.P., Advances in Hepatology . 2014. |
| Yam J.W.P., Journal of Liver: Disease & Transplantation . 2014. |
| Yam J.W.P., PLoS ONE, Public Libraray of Science. 2014. |
| Yam J.W.P., The current understanding of DLC1 tumor suppressor in liver cancer, Department of Chemical Pathology, The Chinese University of Hong Kong. 2015. |
| Researcher : Yan HHN |
| Project Title: | Regulation of stromal miR125b on normal colonic epithelial cell renewal and tumorigenesis |
| Investigator(s): | Yan HHN, Leung SY |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2014 |
| Researcher : Yau TO |
| Project Title: | The role of Frizzled-7, receptor of the WNT/β-catenin signalling pathway, in hepatocellular carcinoma: Implications in tumorigenesis and metastasis |
| Investigator(s): | Yau TO, Ng IOL |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2006 |
| Researcher : Yuen LYP |
| List of Research Outputs |
| Lam C.W., Law C.Y., Leung K.F., Lai C.K., Chen S.P.L., Chan B., Chan K.Y., Yuen L.Y.P., Mak C.M. and Chan A.Y.W., NMR-based urinalysis for rapid diagnosis of β-ureidopropionase deficiency in a patient with Dravet syndrome, Clinica Chimica Acta. 2015, 440: 201-204. |
| Researcher : Yung KY |
| List of Research Outputs |
| Harris I.S., Treloar A.E., Inoue S., Sasaki M., Gorrini C., Lee K.C., Yung K.Y., Brenner D., Knobbe-Thomsen C.B., Cox M.A., Elia A., Berger T., Cescon D.W., Adeoye A., Brüstle A., Molyneux S.D., Mason J.M., Li W.Y., Yamamoto K., Wakeham A., Berman H.K., Khokha R., Done S.J., Kavanagh T.J., Lam C.W. and Mak T.W., Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression, Cancer Cell. 2015, 27: 211-222. |
| Woo P.C.Y., Lam C.W., Tam W.T., Lee K.C., Yung K.Y., Leung K.F., Sze K.H., Lau S.K.P. and Yuen K.Y., The biosynthetic pathway for a thousand-year-old natural food colorant and citrinin in Penicillium marneffei, Scientific Reports. 2014, 4: 6728. |
| Researcher : Zhao F |
| Project Title: | Role of hyperpolarization-activated cyclic nucleotide-gated channel 2 (HCN2) in breast cancer tumorigenesis |
| Investigator(s): | Zhao F, Khoo US |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2015 |
| List of Research Outputs |
| Khongkow P., Gomes A.R., Gong C., Man P.S., Tsang J.W.H., Zhao F., Monteiro L.J., Coombes R.C., Medema R.H., Khoo U.S. and Lam E.W., Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast cancer paclitaxel resistance, Oncogene. 2015. |
| Zhao F., Siu K.Y., Jiang L.L., Tam K.F., Ngan H.Y.S., Le X.F., Wong G.W., Wong E.S.Y., Gomes A.R., Bella L., Khongkow P., Lam E.W. and Cheung A.N.Y., Overexpression of Forkhead Box Protein M1 (FOXM1) in Ovarian Cancer Correlates with Poor Patient Survival and Contributes to Paclitaxel Resistance, PLoS ONE. 2014, 9: e113478. |