DEPT OF MICROBIOLOGY



Researcher : Akhee SJ

List of Research Outputs

To K.K.W., Lee K.C., Wong S.S.Y., Lo K.C., Lui Y.M., Akhee S.J., Wu L., Ke Y., Law C.Y., Sze K.H., Lau S.K.P., Woo P.C.Y., Lam C.W. and Yuen K.Y., Lipid mediators of inflammation as novel plasma biomarkers to identify patients with bacteremia, Journal of Infection. 2015, 70: 433-444.
To K.K.W., Zhang J., Chan S.F., LI C., Cai J., Lau C.Y., Li C., Akhee S.J., Wu W.L., Li L., Tsang K.L., Chan K.H., Chen H. and Yuen K.Y., Recombinant influenza A virus hemagglutinin HA2 subunit protects mice against influenza A(H7N9) virus infection, Archives of Virology. 2015, 160: 777-786.


Researcher : An M

List of Research Outputs

Cheng L., Tang X., Liu L., PENG J., Nishiura K., Cheung K.L.A., GUO J., WU X., Tang H., An M., ZHOU J., Cheung K.W., Wang H., Guan X., Wu Z. and Chen Z., Monoclonal antibodies specific to human Δ42PD1: A novel immunoregulator potentially involved in HIV-1 and tumor pathogenesis, mAbs. 2015, 7: 620-629.


Researcher : BAI R

List of Research Outputs

Lau S.K.P., Woo P.C.Y., Yip C.Y., Li K.S.M., Fan Y.Y., BAI R., Huang Y., Chan K.H. and Yuen K.Y., Chickens host diverse picornaviruses originated from potential interspecies transmission with recombination, Journal of General Virology. 2014, 95: 1929-1944.
Woo P.C.Y., Lau S.K.P., Teng L.L., Tsang K.L., Joseph M., Wong Y.M., TANG Y., Sivakumar S., BAI R., Wernery R., Wernery U. and Yuen K.Y., Metagenomic analysis of viromes of dromedary camel fecal samples reveals large number and high diversity of circoviruses and picobirnaviruses, Virology. 2014, 471-473: 117-125.


Researcher : CHENG Z

List of Research Outputs

CHENG Z., Zhou J., To K.K.W., Chu H., Li C., Song Y., Zheng B. and Yuen K.Y., Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza., Journal of Infectious Diseases. 2015.


Researcher : CHEUNG NN

List of Research Outputs

CHEUNG N.N., Dai J., LAI K.K., YANG F. and Kao R.Y.T., Best Student Poster Award "Identification of a broad-spectrum inhibitor of common RNA respiratory viruses by high-throughput screening", The 28th International Conference on Antiviral Research (ICAR). 2015.


Researcher : CHOI KY

List of Research Outputs

To K.K.W., Tse H., Chan W.M., CHOI K.Y., Zhang J., Sridhar S., Wong S.C.Y., Chan J.F.W., Chan S.F., Woo P.C.Y., Lau S.K.P., Lo J.Y., Chan K.H., Cheng V.C.C. and Yuen K.Y., A novel psittacine adenovirus identified during an outbreak of avian chlamydiosis and human psittacosis: zoonosis associated with virus-bacterium coinfection in birds, PLoS Neglected Tropical Diseases. 2014, 8: e3318.


Researcher : Cai J

List of Research Outputs

Lau S.K.P., Woo P.C.Y., Li K.S.M., Tsang K.L., Fan Y.Y., Luk K.H., Cai J., Chan K.H., Zheng B., Wang M. and Yuen K.Y., Discovery of a novel coronavirus, China Rattus coronavirus HKU24, from Norway rats supports murine origin of Betacoronavirus 1 with implications on the ancestor of Betacoronavirus lineage A, Journal of Virology. 2015, 89: 3076-3092.
To K.K.W., Zhang J., Chan S.F., LI C., Cai J., Lau C.Y., Li C., Akhee S.J., Wu W.L., Li L., Tsang K.L., Chan K.H., Chen H. and Yuen K.Y., Recombinant influenza A virus hemagglutinin HA2 subunit protects mice against influenza A(H7N9) virus infection, Archives of Virology. 2015, 160: 777-786.
Zhang B., HUA Y., Yu B., Lau C.Y., Cai J., Zheng S.Y., Yam W.C., Kao R.Y.T., Sze K.H., Zheng B., Yuen K.Y. and Huang J., Recombinant ESAT-6-Like Proteins Provoke Protective Immune Responses against Invasive Staphylococcus aureus Disease in a Murine Model, Infection and Immunity. 2015, 83: 339-345.


Researcher : Chan CS

List of Research Outputs

LEUNG H.C., Chan C.S., Poon K.M., ZHAO H., Cheung C.Y., Ng F., Huang J. and Zheng B., An H5N1-based matrix protein 2 ectodomain tetrameric peptide vaccine provides cross-protection against lethal infection with H7N9 influenza virus, Emerging Microbes & Infections. 2015, 4: e22.


Researcher : Chan JFW

Project Title:Epidemiology, seroprevalence, and clinical manifestations of immunodeficiency due to autoantibody against interferon gamma in Hong Kong
Investigator(s):Chan JFW, Hung IFN
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Mini Grant
Start Date:01/2014


Project Title:Incidence and clinical significance of Atopobium vaginae bacteremia in Hong Kong.
Investigator(s):Chan JFW, Teng LL
Department:Microbiology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2014


List of Research Outputs

Chan G.C.W., Yap Y.H.D., Kwan L.P., Chan J.F.W., Iu L.P.L., Wong Y.H.I. and Tang S.C.W., Progressive outer retinal necrosis in a renal transplant recipient: a rare treatment success, Transplant Infectious Disease. 2015, 17: 396-399.
Chan J.F.W. and Yuen K.Y., A new ASPECT for complicated urinary tract infections, The Lancet. 2015, 385: 1920-1922.
Chan J.F.W., ASV Medical Virology Club Travel Award, American Society for Virology. 2015.
Chan J.F.W., Approaching the febrile neurosurgical patient, Postgraduate Diploma in Infectious Diseases, HKU. 2015.
Chan J.F.W., Chan K.H., Boudreaux D.M., Swanson M.D., Markovitz D.M. and Yuen K.Y., BanLec, a banana lectin, is a potent inhibitor of Middle East respiratory syndrome coronavirus in in vitro assays, IDWeek 2014, Infectious Diseases Society of America, Philadelphia, PA, USA. 2014.
Chan J.F.W., Body Defense Mechanisms, Post-registration Certificate Course for Nursing, Hospital Authority, Hong Kong. 2014.
Chan J.F.W., Central nervous system infection, Certificate in Infection Control Course, HKU. 2014.
Chan J.F.W., Lau S.K.P., Wong S.C.Y., To K.K.W., Cheng V.C.C. and Yuen K.Y., Comparative analysis of patients with chronic pulmonary aspergillosis and invasive pulmonary aspergillosis: a ten-year retrospective study, 25th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2015), European Society of Clinical Microbiology and Infectious Diseases, Copenhagen, Denmark. 2015.
Chan J.F.W., To K.K.W., Chen H. and Yuen K.Y., Cross-species transmission and emergence of novel viruses from birds, Curr Opin Virol.. 2015, 10: 63-69.
Chan J.F.W., Current therapy for urinary tract infection, Postgraduate Diploma in Diagnosis and Therapeutics in Internal Medicine, HKU. 2015.
Chan J.F.W., Laboratory Diagnosis of Invasive Fungal Infection in Transplant Recipients: Theory & Practice, Workshop on infections in transplant recipients: prevention, control and management, Centre for Health Protection / Hospital Authority, Hong Kong. 2015.
Chan J.F.W., Laboratory Diagnostics for Invasive Fungal Infection: Are They Useful for Clinicians?, Basic Physician Training, Hong Kong West Cluster, The Hong Kong College of Physicians, Hong Kong. 2015.
Chan J.F.W., Lau S.K.P., To K.K.W., Cheng V.C.C., Woo P.C.Y. and Yuen K.Y., Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease, Clinical Microbiology Reviews. 2015, 28: 465-522.
Chan J.F.W., Opportunistic Infection & Management of the Immunocompromised & Pancytopenic Patients, Post-registration Certificate Course for Nursing, Hospital Authority, Hong Kong. 2014.
Chan J.F.W., Preventing antibiotic allergy: a critical role of the nursing staff, Certificate in Infection Control Course, HKU. 2014.
Chan J.F.W., Respiratory viral outbreak: Future ahead, The 19th Congress of Asian Pacific Society of Respirology, Asian Pacific Society of Respirology, Bali, Indonesia. 2014.
Chan J.F.W., SARS outbreak: What have we learned?, The 19th Congress of Asian Pacific Society of Respirology, Asian Pacific Society of Respirology, Bali, Indonesia. 2014.
Chan J.F.W., The Changing Face of Coronaviruses: Coronaviruses - Options for Treatment, Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) 2014, American Society for Microbiology. 2014.
Chan J.F.W., Update on Middle East respiratory syndrome coronavirus (MERS-CoV), Postgraduate Diploma in Infectious Diseases, HKU. 2014.
Chan J.F.W., Viral pneumonia: diagnosis and management, The 19th Congress of Asian Pacific Society of Respirology, Asian Pacific Society of Respirology, Bali, Indonesia. 2014.
Chan J.F.W., When Should You Suspect Brucellosis?, Postgraduate Diploma in Infectious Diseases, HKU. 2014.
Chan W.S., Chan T.M., Lai T.W., Chan J.F.W., Lai R.W.M., Lai C.K.C. and Tang S.F., Complementary use of MALDI-TOF MS and real-time PCR-melt curve analysis for rapid identification of methicillin-resistant staphylococci and VRE, Journal of Antimicrobial Chemotherapy. 2015, 70: 441-447.
Chen Y., Chan K.H., Kang Y., Chen H., Luk K.H., Poon R.W.S., Chan J.F.W., Yuen K.Y., Xia N., Lau S.K.P. and Woo P.C.Y., A sensitive and specific antigen detection assay for Middle East respiratory syndrome coronavirus, Emerging Microbes and Infections. 2015, 4: e26.
Cheng V.C.C., Chen J.H.K., Poon R.W.S., Lee W.M., So S.Y.C., Wong S.C.Y., Chau P.H., Yip C.Y., Wong S.S.Y., Chan J.F.W., Hung I.F.N., Ho P.L. and Yuen K.Y., Control of hospital endemicity of multiple-drug-resistant Acinetobacter baumannii ST457 with directly observed hand hygiene, European Journal of Clinical Microbiology & Infectious Diseases. 2015, 34: 713-718.
Cheng V.C.C., Chen J.H.K., Tai J.W.M., Wong S.C.Y., Poon W.S.R., Hung I.F.N., Chan J.F.W., Ho P.L., Lo C.M. and Yuen K.Y., Decolonization of gastrointestinal carriage of vancomycin-resistant Enterococcus faecium: case series and review of literature, BMC Infectious Diseases. 2014, 14: 514.
Cheng V.C.C., Tai J.W., Lee W.M., Chan W.M., Wong S.C.Y., Chen J.H.K., Poon W.S.R., To K.K.W., Chan J.F.W., Ho P.L., Chan K.H. and Yuen K.Y., Infection Control Preparedness for Human Infection With Influenza A H7N9 in Hong Kong, Infection Control & Hospital Epidemiology. 2015, 36: 87-92.
Ho P.L., Sin W.C., Chan J.F.W., Cheng V.C.C. and Chan K.H., Severe influenza A H7N9 pneumonia with rapid virological response to intravenous zanamivir, European Respiratory Journal. 2014, 44: 535-537.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Best Abstract in Clinical Medicine (Oral) - "Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial", 20th Medical Research Conference 2015, Department of Medicine, The University of Hong Kong . 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial, 20th Medical Research Conference, The University of Hong Kong, 17 Jan 2015. (Oral presentation - Best abstract in Clinical Medicine) . 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial, Clinical Infectious Diseases . 2014, 59(9): 1246-55.
Lam J.Y., Wu A.K., Leung W.S., Cheung I., TSANG C.C., Chen J.H.K., Chan J.F.W., Tse C.W., Lee R.A., Lau S.K.P. and Woo P.C.Y., Gordonia species as emerging causes of continuous ambulatory peritoneal dialysis-related peritonitis identified by 16S rRNA and secA1 genes sequencing and MALDI-TOF MS, Journal of Clinical Microbiology. 2015, 53: 671-676.
Lau G.K.K., Chan L.K., Li O.Y., Yuen T.K., Wong Y.K., Chan K.H., Chan J.F.W., Chang S.K.R., Cheung R.T.F., Doherty I., Ho S.L., Hon F.K.S., Kwan S.K.J., Lee R., Leung G.K.K., Mak W., Mak H.K.F., Shih K.C. and Tsang C.O.A., Establishing an eLearning Platform in Clinical Neurosciences, East-West Alliance Global Symposia 2014.
Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Lau C.Y., Chow W.N., Ngan A.H., To K.K.W., Chan J.F.W., Hung I.F.N., Yam W.C., Yuen K.Y. and Woo P.C.Y., Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics: exploration of potential biomarkers, Emerging Microbes & Infections. 2015, 4: e6.
Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Lau C.Y., Chow W.N., Ngan A.H., To K.K.W., Chan J.F.W., Hung I.F.N., Yam W.C., Yuen K.Y. and Woo P.C.Y., Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics: exploration of potential biomarkers, Emerging Microbes and Infections. 2015, 4: e6.
Lee K.C., Tam W.T., Lo K.C., Tsang K.L., Lau C.Y., To K.K.W., Chan J.F.W., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Metabolomics Analysis Reveals Specific Novel Tetrapeptide and Potential Anti-Inflammatory Metabolites in Pathogenic Aspergillus species, International Journal of Molecular Sciences. 2015, 16: 13850-13867.
Li C., Li C., Zhang J., To K.K.W., Lee C.Y., Zhu H., Wu W.L., Chan J.F.W., Chen H., Hung I.F.N., Li L. and Yuen K.Y., Avian Influenza A H7N9 Virus Induces Severe Pneumonia in Mice without Prior Adaptation and Responds to a Combination of Zanamivir and COX-2 Inhibitor , PLoS One. 2014, 9(9): e107966.
Sridhar S., To K.K.W., Chan J.F.W., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., A systematic approach to novel virus discovery in emerging infectious disease outbreaks, Journal of Molecular Diagnostics. 2015, 17: 230-241.
Sridhar S., Chan J.F.W. and Yuen K.Y., Fatal anti-aquaporin-4 seropositive neuromyelitis optica spectrum disorder in tuberculosis, BMC Infectious Diseases. 2014, 14: 470.
TSANG C.C., Chan J.F.W., Trendell-Smith N.J., Ngan A.H., Ling I.W., Lau S.K.P. and Woo P.C.Y., Subcutaneous phaeohyphomycosis in a patient with IgG4-related sclerosing disease caused by a novel ascomycete, Hongkongmyces pedis gen. et sp. nov.: first report of human infection associated with the family Lindgomycetaceae, Medical Mycology. 2014, 52: 736-747.
To K.K.W., Tse H., Chan W.M., CHOI K.Y., Zhang J., Sridhar S., Wong S.C.Y., Chan J.F.W., Chan S.F., Woo P.C.Y., Lau S.K.P., Lo J.Y., Chan K.H., Cheng V.C.C. and Yuen K.Y., A novel psittacine adenovirus identified during an outbreak of avian chlamydiosis and human psittacosis: zoonosis associated with virus-bacterium coinfection in birds, PLoS Neglected Tropical Diseases. 2014, 8: e3318.
To K.K.W., Chan J.F.W., Tsang K.L., Cheng V.C.C. and Yuen K.Y., Ebola virus disease: a highly fatal infectious disease reemerging in West Africa, Microbes and Infection. 2015, 17: 84-97.
Tsang C.L., Chan J.F.W., Ip P.C.P., Ngan A.H.Y., Chen J.H.K., Lau S.K.P. and Woo P.C.Y., Subcutaneous Phaeohyphomycotic Nodule Due to Phialemoniopsis hongkongensis sp. nov., In: Alexander J. McAdam, MD, Journal of Clinical Microbiology. American Society for Microbiology (ASM), 2014, 52: 3280-3289.
Wang Y.F., Xu H.F., Han Z.G., Zeng L., Liang C.Y., Chen X.J., Chen Y.J., Cai J.P., Hao W., Chan J.F.W., Wang M., Fu N. and Che X.Y., Serological surveillance for Penicillium marneffei infection in HIV-infected patients during 2004–2011 in Guangzhou, China, Clinical Microbiology and Infection. 2015, 21: 484-489.
Woo P.C.Y., Wu A.K., TSANG C.C., Leung K.W., Ngan A.H., Curreem S.O.T., Lam K.W., Chen J.H.K., Chan J.F.W. and Lau S.K.P., Streptobacillus hongkongensis sp. nov., isolated from patients with quinsy and septic arthritis in Hong Kong and emended descriptions of the genus Streptobacillus and the species Streptobacillus moniliformis, International Journal of Systematic and Evolutionary Microbiology. 2014, 64: 3034-3039.


Researcher : Chan KCW

List of Research Outputs

To W.C.S., Chen J.H.K., Wong K.H., Chan K.C.W., Ng H.M. and Yam W.C., Molecular epidemiology and phylogenetic analysis of minor HIV-1 subtypes in Hong Kong: Emergence and spread of CRF07_BC and subtype C, 25th European Congress of Clinical Microbiology and Infectious Diseases. 2015.


Researcher : Chan KH

List of Research Outputs

Chan J.F.W., Chan K.H., Boudreaux D.M., Swanson M.D., Markovitz D.M. and Yuen K.Y., BanLec, a banana lectin, is a potent inhibitor of Middle East respiratory syndrome coronavirus in in vitro assays, IDWeek 2014, Infectious Diseases Society of America, Philadelphia, PA, USA. 2014.
Chan T.C.I., Hung I.F.N., Chan K.H., Li P.Y., Li T.W., Luk J.K.H., Chu L.W. and Chan H.W.F., A Randomized Controlled Trial to Compare Immunogenicity Between Intramuscular and Intradermal Trivalent Influenza Vaccination in Nursing Home Older Adults, 20th Medical Research Conference, The University of Hong Kong, 17 Jan 2015.. 2015.
Chan T.C.I., Hung I.F.N., Chan K.H., Li P.Y., Li T.W., Luk J.K.H., Chu L.W. and Chan H.W.F., Local Adverse Effect of Intradermal and Administration of Influenza Vaccination is an Indicator of Satisfactory Immunogenicity, 20th Medical Research Conference 2015, The University of Hong Kong, 17 Jan 2015. . 2015.
Chen Y., Chan K.H., Kang Y., Chen H., Luk K.H., Poon R.W.S., Chan J.F.W., Yuen K.Y., Xia N., Lau S.K.P. and Woo P.C.Y., A sensitive and specific antigen detection assay for Middle East respiratory syndrome coronavirus, Emerging Microbes and Infections. 2015, 4: e26.
Cheng V.C.C., Tai J.W., Lee W.M., Chan W.M., Wong S.C.Y., Chen J.H.K., Poon W.S.R., To K.K.W., Chan J.F.W., Ho P.L., Chan K.H. and Yuen K.Y., Infection Control Preparedness for Human Infection With Influenza A H7N9 in Hong Kong, Infection Control & Hospital Epidemiology. 2015, 36: 87-92.
Chiang A.K.S., NING J. and Chan K.H., Emergence of highly functional antigen-specific T cells towards Epstein-Barr virus corresponds to viral control and enhanced cytotoxicity in children with infectous mononucleosis and primary asymptomatic infection, 16th International Symposium on EBV and Associated Diseases. 2014.
Chiu S.S.S., Ho P.L., Peiris J.S.M., Chan K.H. and Chan L.Y., Population-based hospitalization incidence of respiratory viruses in community-acquired pneumonia in children younger than 5 years of age, Influenza and Other Respiratory Viruses. 2014, 8(6): 626-7.
Cowling B.J., Perera R.A.P.M., Fang J., Chan K.H., Lim Wai S.K.W., So H.C., Chu K.W., Wong Y.T., Shiu E.Y.C., Ng S., Ip D.K.M., Peiris J.S.M. and Leung G.M., Incidence of influenza virus infections in children in Hong Kong in a 3-year randomized placebo-controlled vaccine study, 2009-2012, Clinical Infectious Diseases . 2014, 59(4): 517-24.
Cowling B.J., Perera R.A.P.M., Fang J., Chan K.H., Wong Y.T., Ng S., Ip D.K.M., Peiris J.S.M. and Leung G.M., Incidence of influenza virus infections in children in Hong Kong in a three year randomized placebo-controlled vaccine study (abstract & poster presentation), Influenza 2014: One Influenza, One World, One Health, 9-11 September 2014, Oxford, UK. UK, LibPubMedia Ltd, 2014.
Cowling B.J., Chan K.H., Feng S., Chan L.Y., Lo J.Y.C., Peiris J.S.M. and Chiu S.S.S., The effectiveness of influenza vaccination in preventing hospitalizations in children in Hong Kong, 2009–2013, Vaccine. Elsevier, 2014, 32: 5278-5284.
Ho P.L., Sin W.C., Chan J.F.W., Cheng V.C.C. and Chan K.H., Severe influenza A H7N9 pneumonia with rapid virological response to intravenous zanamivir, European Respiratory Journal. 2014, 44: 535-537.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Best Abstract in Clinical Medicine (Oral) - "Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial", 20th Medical Research Conference 2015, Department of Medicine, The University of Hong Kong . 2015.
Hung I.F.N., Chan K.H., Liang R.H.S., Lai T.S.T. and Yuen K.Y., Harvesting Convalescent Plasma for Hyperimmune Intravenous Globulin Production: A Multicentre Randomized Double-Blind Controlled Trial for Treatment of Patients with Serious S-OIV H1N1 Infection, Health Research Symposium 2014, Hong Kong, 15 Nov 2014. (Poster presentation). 2014.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial, 20th Medical Research Conference, The University of Hong Kong, 17 Jan 2015. (Oral presentation - Best abstract in Clinical Medicine) . 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial, Clinical Infectious Diseases . 2014, 59(9): 1246-55.
Lau S.K.P., Woo P.C.Y., Yip C.Y., Li K.S.M., Fan Y.Y., BAI R., Huang Y., Chan K.H. and Yuen K.Y., Chickens host diverse picornaviruses originated from potential interspecies transmission with recombination, Journal of General Virology. 2014, 95: 1929-1944.
Lau S.K.P., Woo P.C.Y., Li K.S.M., Tsang K.L., Fan Y.Y., Luk K.H., Cai J., Chan K.H., Zheng B., Wang M. and Yuen K.Y., Discovery of a novel coronavirus, China Rattus coronavirus HKU24, from Norway rats supports murine origin of Betacoronavirus 1 with implications on the ancestor of Betacoronavirus lineage A, Journal of Virology. 2015, 89: 3076-3092.
Nicholls J.M., Tsai P.N., Chan W.Y., Hui P.Y., Chan M.C.W., Peiris J.S.M., Chan K.H., Yuen K.Y. and To K.K.W., Fatal H7N9 pneumonia complicated by viral infection of a prosthetic cardiac valve – An autopsy study, Journal of Clinical Virology. 2014, 61(3): 466-9.
To K.K.W., Tse H., Chan W.M., CHOI K.Y., Zhang J., Sridhar S., Wong S.C.Y., Chan J.F.W., Chan S.F., Woo P.C.Y., Lau S.K.P., Lo J.Y., Chan K.H., Cheng V.C.C. and Yuen K.Y., A novel psittacine adenovirus identified during an outbreak of avian chlamydiosis and human psittacosis: zoonosis associated with virus-bacterium coinfection in birds, PLoS Neglected Tropical Diseases. 2014, 8: e3318.
To K.K.W., Zhang J., Chan S.F., LI C., Cai J., Lau C.Y., Li C., Akhee S.J., Wu W.L., Li L., Tsang K.L., Chan K.H., Chen H. and Yuen K.Y., Recombinant influenza A virus hemagglutinin HA2 subunit protects mice against influenza A(H7N9) virus infection, Archives of Virology. 2015, 160: 777-786.
WANG X., Wong C.M., Yang L., Chan K.H., Soares Magalhaes R.J..., Clements A.C...A..., Tong S.L. and Hu W.B., Developing an epidemic forecasting model for influenza A in Brisbane, Australia based on climate and Hong Kong influenza A surveillance data, Clinical Infectious Diseases. 2014, 59(10): 1508-9.
WONG A.M.G., NING J., Chan K.H. and Chiang A.K.S., Longitudinal study of viral loads and polyfunctional T cell responses towards Epstein-Barr virus in paediatric liver transplant recipients who developed post-transpleant lymphoproliferative disorder, 16th International Symposium on EBV and Associated Diseases. 2014.
Wong K.S.C., Tsang G.C.H., Chan K.H., Li O.T.W., Peiris J.S.M. and Poon L.L.M., A novel molecular test for influenza B virus detection and lineage differentiation, Journal of Medical Virology. 2014, 86(12): 2171-6.
Woo P.C.Y., Lau S.K.P., Martelli P., Hui S.W., Lau C.Y., Fan Y.Y., Groff J.M., Tam W.T., Chan K.H. and Yuen K.Y., Fatal systemic necrotizing infections associated with a novel paramyxovirus, anaconda paramyxovirus, in green anaconda juveniles, Journal of Clinical Microbiology. 2014, 52: 3614-3623.
Yang L., Chan K.H., Suen L.K.P., Chan K.P., WANG X., CAO P., He D., Peiris J.S.M. and Wong C.M., Age-specific epidemic waves of influenza and respiratory syncytial virus in a subtropical city, Scientific Reports. 2015, 5: 10390.
Yang L., Chan K.H., Suen L.K.P., Chan K.P., WANG X., CAO P., He D., Peiris J.S.M. and Wong C.M., Impact of the 2009 H1N1 Pandemic on Age-Specific Epidemic Curves of Other Respiratory Viruses: A Comparison of Pre-Pandemic, Pandemic and Post-Pandemic Periods in a Subtropical City, PLoS One. 2015, 10(4): e0125447.
Yip C.Y., Lo K.L., Que T.L., Lee R.A., Chan K.H., Yuen K.Y., Woo P.C.Y. and Lau S.K.P., Epidemiology of human parechovirus, Aichi virus and salivirus in fecal samples from hospitalized children with gastroenteritis in Hong Kong, Virology Journal. 2014, 11: 182.


Researcher : Chan MCW

Project Title:Effect of vitamin B2 in the treatment of human influenza H5N1 virus infection: studies in vitro and in vivo
Investigator(s):Chan MCW, Peiris JSM, Chan WY
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:02/2009
Completion Date:08/2014


Project Title:Experimental models to study the impact of cigarette smoking on the tropism of the highly pathogenic avian influenza H5N1 virus in human respiratory tract
Investigator(s):Chan MCW, Chan WY, Nicholls JM, Mak JCW
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:02/2011


Project Title:Role of indirubin-3’-oxime as an antiviral and immunomodulatory agent in the treatment of severe human influenza virus infection
Investigator(s):Chan MCW
Department:School of Public Health
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:03/2012


Project Title:Therapeutic Effect of Human Umbilical Cord Mesenchymal Stem Cells on Acute Lung Injury Caused by Severe Influenza H5N1 Virus Infection
Investigator(s):Chan MCW, Peiris JSM, Guan Y, Chan GCF, Chan WY
Department:School of Public Health
Source(s) of Funding:Matching Grant for Joint Research
Start Date:05/2012


Project Title:A mouse model to study the beneficial effect of human mesenchymal stem cells on acute lung injury induced by influenza H5N1 virus infection
Investigator(s):Chan MCW
Department:School of Public Health
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2013
Completion Date:02/2015


Project Title:Role of distal airway stem cells in lung regeneration following highly pathogenic influenza H5N1 induced acute lung injury
Investigator(s):Chan MCW, Wong MP, Nicholls JM
Department:School of Public Health
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2014


Project Title:Tropism of the novel human betacoronavirus lineage C virus in human ex vivo and in vitro cultures, as an assessment of its potential transmissibility and pathogenesis in humans
Investigator(s):Chan MCW, Chan WY, Nicholls JM, Peiris JSM
Department:School of Public Health
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:03/2014


Project Title:Host-directed antiviral strategy for influenza virus infection – optimization of statins use and the intimate linkage between sterol metabolism and interferon mediated antiviral response
Investigator(s):Chan MCW
Department:School of Public Health
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2014


Project Title:Tissue tropism and mammalian adaptations of avian H9N2 influenza A virus in human respiratory tract
Investigator(s):Chan MCW
Department:School of Public Health
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2015




Researcher : Chan SF

List of Research Outputs

To K.K.W., Tse H., Chan W.M., CHOI K.Y., Zhang J., Sridhar S., Wong S.C.Y., Chan J.F.W., Chan S.F., Woo P.C.Y., Lau S.K.P., Lo J.Y., Chan K.H., Cheng V.C.C. and Yuen K.Y., A novel psittacine adenovirus identified during an outbreak of avian chlamydiosis and human psittacosis: zoonosis associated with virus-bacterium coinfection in birds, PLoS Neglected Tropical Diseases. 2014, 8: e3318.
To K.K.W., Zhang J., Chan S.F., LI C., Cai J., Lau C.Y., Li C., Akhee S.J., Wu W.L., Li L., Tsang K.L., Chan K.H., Chen H. and Yuen K.Y., Recombinant influenza A virus hemagglutinin HA2 subunit protects mice against influenza A(H7N9) virus infection, Archives of Virology. 2015, 160: 777-786.


Researcher : Chan WM

List of Research Outputs

To K.K.W., Tse H., Chan W.M., CHOI K.Y., Zhang J., Sridhar S., Wong S.C.Y., Chan J.F.W., Chan S.F., Woo P.C.Y., Lau S.K.P., Lo J.Y., Chan K.H., Cheng V.C.C. and Yuen K.Y., A novel psittacine adenovirus identified during an outbreak of avian chlamydiosis and human psittacosis: zoonosis associated with virus-bacterium coinfection in birds, PLoS Neglected Tropical Diseases. 2014, 8: e3318.


Researcher : Chen H

Project Title:Modification of cells for isolation and characterization of SARS CoV from animal sources
Investigator(s):Chen H
Department:Microbiology
Source(s) of Funding:Seed Funding for New Staff
Start Date:07/2004


Project Title:Biological function/relevance for the 29 nucleotides insertion in the genome of animal SARS like CoV
Investigator(s):Chen H, Guan Y
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:11/2004


Project Title:Antiviral drug resistance in H5N1 virus
Investigator(s):Chen H, Guan Y
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:01/2007


Project Title:The role of RAP55 and P-bodies in the regulation of influenza virus replication
Investigator(s):Chen H
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2014


Project Title:16th International Symposium on EBV and Associated Diseases ; Characterization of extracellular secreted Epstein-Barr virus BART microRNAs as serological markers for nasopharyngeal carcinoma diagnosis and treatment
Investigator(s):Chen H
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:07/2014


Project Title:Adaptive strategies of the H7N9 virus PB2 polymerase for replication in humans
Investigator(s):Chen H
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2015


List of Research Outputs

Chan J.F.W., To K.K.W., Chen H. and Yuen K.Y., Cross-species transmission and emergence of novel viruses from birds, Curr Opin Virol.. 2015, 10: 63-69.
Chen H., Excellent Research Award, Food and Health Bureau, HKSAR, HMRF,Food and Health Bureau, HKSAR. 2014.
Chen H., Auto-regulatory loop between EBV LMP1 mediated NF-B signaling and BART miRNA expression to facilitate nasopharyngeal carcinoma to evade immune surveillance., 中國免疫學會第九屆全國免疫學學術大會, Jinan, 19 to 22 Oct, 2014. 2014.
Chen H., Characterization of extracellular secreted Epstein-Barr virus BART microRNAs as serological markers for nasopharyngeal carcinoma diagnosis and treatment., 16th International Symposium on EBV and Associated Diseases, Brisbane, Australia, 16 - 19 July, 2014.. 2014.
Chen H. and Guan Y., H5N1 virus resistant to antiviral drug, Hong Kong Medical Journal . 2015, 21(Suppl 4): S12-3.
Chen Y., Chan K.H., Kang Y., Chen H., Luk K.H., Poon R.W.S., Chan J.F.W., Yuen K.Y., Xia N., Lau S.K.P. and Woo P.C.Y., A sensitive and specific antigen detection assay for Middle East respiratory syndrome coronavirus, Emerging Microbes and Infections. 2015, 4: e26.
Gao H.N., Yao H.P., Liang W.F., Wu X.X., Wu H.B., Wu N.P., Yang S.G., Zhang Q., Su K.K., Guo J., Zheng S.F., Zhu Y.X., Chen H., Yuen K.Y. and Li L.J., Viral genome and antiviral drug sensitivity analysis of two patients from a family cluster caused by the influenza A(H7N9) virus in Zhejiang, China, 2013, Int J Infect Dis.. 2014, 29(2014): 254-258.
Li C., Li C., Zhang J., To K.K.W., Lee C.Y., Zhu H., Wu W.L., Chan J.F.W., Chen H., Hung I.F.N., Li L. and Yuen K.Y., Avian Influenza A H7N9 Virus Induces Severe Pneumonia in Mice without Prior Adaptation and Responds to a Combination of Zanamivir and COX-2 Inhibitor , PLoS One. 2014, 9(9): e107966.
Song W., Wang P., Mok B.W.Y., Lau S.Y., HUANG X., Wu W.L., ZHENG M., WEN X., Yang S., Chen Y., Li L., Yuen K.Y. and Chen H., The K526R substitution in viral protein ​PB2 enhances the effects of E627K on influenza virus replication, Nature Communications. 2014.
To K.K.W., Zhang J., Chan S.F., LI C., Cai J., Lau C.Y., Li C., Akhee S.J., Wu W.L., Li L., Tsang K.L., Chan K.H., Chen H. and Yuen K.Y., Recombinant influenza A virus hemagglutinin HA2 subunit protects mice against influenza A(H7N9) virus infection, Archives of Virology. 2015, 160: 777-786.
To K.K.W., Song W., Lau S.Y., Que T.L., Lung D.C., Hung I.F.N., Chen H. and Yuen K.Y., Unique reassortant of influenza A(H7N9) virus associated with severe disease emerging in Hong Kong, Journal of Infection. 2014, 69(1): 60-68.
XIANG Z., Liu Y., Zheng J., Liu M., LU A., GAO Y., Hu H., Lam K.T., Chan G.C.F., Yang Y., Chen H., Tsao G.S.W., Bonneville M M., Lau Y.L. and Tu W., Targeted Activation of Human Vγ9Vδ2-T Cells Controls Epstein-Barr Virus-Induced B Cell Lymphoproliferative Disease, Cancer Cell. 2014.
Yuen K.S., Chan C.P., Wong N.H.M., HO C.H., HO T.H., Lei T., Deng W., Tsao G.S.W., Chen H., Kok K.H. and Jin D., CRISPR/Cas9-mediated genome editing of Epstein-Barr virus in human cells, Journal of General Virology. 2015, 96: 626-636.
Zhang G., Zong J., VERHOEVEN R.J.A., TONG S., Ji M., Cheng W., Lung M.L., Tsao G.S.W., Pan J. and Chen H., Characterization of extracellular secreted Epstein-Barr virus BART microRNAs as serological markers for nasopharyngeal carcinoma diagnosis and treatment, 16th International Symposium On Epstein-barr Virus And Associated Diseases, July 16-19, 2014, Brisbane, Australia. 2014.


Researcher : Chen JHK

Project Title:Molecular epidemiology study of HIV-1 among the men who have sex with men (MSM) population in Hong Kong
Investigator(s):Chen JHK, Yam WC
Department:Microbiology
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:04/2009


List of Research Outputs

Chen J.H.K., She K.K.K., Wong O.Y., Teng L.L., Yam W.C., Lau S.K.P., Woo P.C.Y., Cheng V.C.C. and Yuen K.Y., Use of MALDI Biotyper plus ClinProTools mass spectra analysis for correct identification of Streptococcus pneumoniae and Streptococcus mitis / oralis , Journal of Clinical Pathology. 2015, jclinpath-2014-202818.
Cheng V.C.C., Chen J.H.K., Poon R.W.S., Lee W.M., So S.Y.C., Wong S.C.Y., Chau P.H., Yip C.Y., Wong S.S.Y., Chan J.F.W., Hung I.F.N., Ho P.L. and Yuen K.Y., Control of hospital endemicity of multiple-drug-resistant Acinetobacter baumannii ST457 with directly observed hand hygiene, European Journal of Clinical Microbiology & Infectious Diseases. 2015, 34: 713-718.
Cheng V.C.C., Chen J.H.K., Tai J.W.M., Wong S.C.Y., Poon W.S.R., Hung I.F.N., Chan J.F.W., Ho P.L., Lo C.M. and Yuen K.Y., Decolonization of gastrointestinal carriage of vancomycin-resistant Enterococcus faecium: case series and review of literature, BMC Infectious Diseases. 2014, 14: 514.
Lam J.Y., Wu A.K., Leung W.S., Cheung I., TSANG C.C., Chen J.H.K., Chan J.F.W., Tse C.W., Lee R.A., Lau S.K.P. and Woo P.C.Y., Gordonia species as emerging causes of continuous ambulatory peritoneal dialysis-related peritonitis identified by 16S rRNA and secA1 genes sequencing and MALDI-TOF MS, Journal of Clinical Microbiology. 2015, 53: 671-676.
Lau S.K.P., Wu A.K.L., Teng L.L., Tse H., Curreem S.O.T., Tsui S.K.W., Huang Y., Chen J.H.K., Lee R.A., Yuen K.Y. and Woo P.C.Y., Evidence for Elizabethkingia anophelis transmission from mother to infant, Hong Kong., Emerging Infectious Diseases. 2015, 21: 232-241.
Luo Y., Siu G.K.H., Yeung A.S.F., Chen J.H.K., Ho P.L., Leung K.W., Tsang L.Y., Cheng V.C.C., Guo L., Yang J., Ye L. and Yam W.C., Performance of the VITEK MS matrix-assisted laser desorption ionization-time of flight mass spectrometry system for rapid bacterial identification in two diagnostic centres in China, Journal of Medical Microbiology. 2015, 64: 18-24.
Teng L.L., Huang Y., Tse H., Chen J.H.K., TANG Y., Lau S.K.P. and Woo P.C.Y., Phylogenomic and MALDI-TOF MS analysis of Streptococcus sinensis HKU4T reveals a distinct phylogenetic clade in the genus Streptococcus, Genome Biology and Evolution. 2014, 6: 2930-2943.
To W.C.S., Chen J.H.K., Wong K.H., Chan K.C.W., Ng H.M. and Yam W.C., Molecular epidemiology and phylogenetic analysis of minor HIV-1 subtypes in Hong Kong: Emergence and spread of CRF07_BC and subtype C, 25th European Congress of Clinical Microbiology and Infectious Diseases. 2015.
Tsang C.L., Chan J.F.W., Ip P.C.P., Ngan A.H.Y., Chen J.H.K., Lau S.K.P. and Woo P.C.Y., Subcutaneous Phaeohyphomycotic Nodule Due to Phialemoniopsis hongkongensis sp. nov., In: Alexander J. McAdam, MD, Journal of Clinical Microbiology. American Society for Microbiology (ASM), 2014, 52: 3280-3289.
Woo P.C.Y., Wu A.K., TSANG C.C., Leung K.W., Ngan A.H., Curreem S.O.T., Lam K.W., Chen J.H.K., Chan J.F.W. and Lau S.K.P., Streptobacillus hongkongensis sp. nov., isolated from patients with quinsy and septic arthritis in Hong Kong and emended descriptions of the genus Streptobacillus and the species Streptobacillus moniliformis, International Journal of Systematic and Evolutionary Microbiology. 2014, 64: 3034-3039.


Researcher : Chen M

Project Title:Immunogenicity and Cross-Protective Effect of Novel human T cell Epitopes in H5N1 influenza virus nucleoprotein
Investigator(s):Chen M, Zheng B
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:10/2010




Researcher : Chen Z

Project Title:A novel model for the study of lung pathogenesis of SARS
Investigator(s):Chen Z
Department:LKS Medical Faculty
Source(s) of Funding:National Institutes of Health, US Department of Health and Human Services - General Award
Start Date:08/2007


Project Title:Understanding the Ongoing HIV Epidemic in Yunnan China
Investigator(s):Chen Z
Department:LKS Medical Faculty
Source(s) of Funding:China AIDS Initiative - General Award
Start Date:05/2008


Project Title:Preventing HIV-1 infection using a novel vaccine immunogen
Investigator(s):Chen Z
Department:LKS Medical Faculty
Source(s) of Funding:Global Health Grants
Start Date:10/2008


Project Title:Establishment of a rapid, high-throughput, cost-effective HIV-1 drug resistance testing system
Investigator(s):Chen Z
Department:Microbiology
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:05/2011


Project Title:A Novel Vaccine for Mesothelioma Immunotherapy and Prevention;
Investigator(s):Chen Z
Department:Microbiology
Source(s) of Funding:Pneumoconiosis Compensation Fund Board - General Award
Start Date:07/2011


Project Title:A promising mucosal prime and intramuscular boost AIDS vaccine regimen
Investigator(s):Chen Z
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2011
Completion Date:08/2014


Project Title:AIDS Vaccine 2011 A Novel Vaccine Design for Inducing Robust HIV-1 Specific Immunity
Investigator(s):Chen Z
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:09/2011


Project Title:Blocking HIV infection by gene-encoding neutralizing antibodies
Investigator(s):Chen Z, Liu L
Department:Microbiology
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2012


Project Title:AIDS Vaccine 2012; Mucosal Prime with a Replicating Vaccinia-based Vaccine Promotes Mucosal Immunity against SIV.
Investigator(s):Chen Z
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:09/2012


Project Title:Mechanism of a soluble PD-1-based vaccine in amplifying antiviral CD8+ T-cell immunity
Investigator(s):Chen Z, Liu L
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2013


Project Title:Novel Secretory Immunoadhesins for HIV Prevention
Investigator(s):Chen Z, Cheung KLA
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:03/2013


Project Title:To Establish a Novel and Rapid Phenotypic HIV-1 Drug Resistance Testing System
Investigator(s):Chen Z, Liu L, Cheung KW, Du DY
Department:Microbiology
Source(s) of Funding:Guangdong-Hong Kong Technology Cooperation Funding Scheme
Start Date:07/2013


Project Title:Further optimization of live viral vector for HIV vaccine research
Investigator(s):Chen Z, Wang H
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:11/2013


Project Title:To Establish a Novel and Rapid Phenotypic HIV-1 Drug Resistance Testing System
Investigator(s):Chen Z, Liu L, Cheung KW, Du DY
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:12/2013


Project Title:Mechanism of potentiating HIV antigen-specific CD8+ T cells
Investigator(s):Chen Z, Liu L, Yam WC, Cheung KLA, Cheung KW
Department:Microbiology
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2014


Project Title:A New Therapeutic Vaccine for HIV/AIDS
Investigator(s):Chen Z, Cheung KW
Department:Microbiology
Source(s) of Funding:Innovation and Technology Support Programme (Tier 3)
Start Date:12/2014


Project Title:Role of a newly identified PD-1 isoform in modulating immune responses
Investigator(s):Chen Z, Cheung KLA
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2015


Project Title:A New Therapeutic Vaccine for HIV/AIDS
Investigator(s):Chen Z, Cheung KW
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2015


Project Title:A novel PDI DNA-based vaccination strategy to mimic Gag-specific responses found in HIV Elite controllers
Investigator(s):Chen Z
Department:Microbiology
Source(s) of Funding:ANR / RGC Joint Research Scheme
Start Date:04/2015


Project Title:Role of Δ42PD1 in HIV Infection
Investigator(s):Chen Z, Cheung KLA
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2015


List of Research Outputs

Chen Z., Chen, Zhiwei, Zhou, Jingying : Soluble PD-1 Variants, Fusion Constructs, and Uses Thereof. US patent no. 9,029,315 issued on 12 May 2015., 2015.
Cheng L., Tang X., Liu L., PENG J., Nishiura K., Cheung K.L.A., GUO J., WU X., Tang H., An M., ZHOU J., Cheung K.W., Wang H., Guan X., Wu Z. and Chen Z., Monoclonal antibodies specific to human Δ42PD1: A novel immunoregulator potentially involved in HIV-1 and tumor pathogenesis, mAbs. 2015, 7: 620-629.
GUO J., Zuo T., Cheng L., WU X., TANG J., Sun C.J., Feng L., Chen L., Zhang L.Q. and Chen Z., Simian Immunodeficiency Virus Infection Evades Vaccine-Elicited Antibody Responses to V2 Region, JAIDS Journal of Acquired Immune Deficiency Syndromes. 2015, 68: 502-510.
LIANG J., Liu L., Chen M.A.N.D.Y., Li M.A.N.-.P.O., Li C.H.U.N.-.H.O., Chan C.H.U.N.-.C.H.U.N.G., TANG X., PENG J., Cheung K.W., Yam W.C. and Chen Z., Community-based HIV-1 Early Diagnosis and Risk Behavior Analysis of Men Having Sex with Men in Hong Kong, PLOS one. 2015, Apr 27;10: 4.
Liu L., Liang J., Cheung M., Lee M. and Chen Z., Community-based HIV-1 Early Diagnosis and Risk Behavior Analysis of Men Having Sex with Men in Hong Kong. , 20th International AIDS Conference . 2014.
Liu L., Chen J. and Chen Z., Patent No: 61/917,175.Title: Use of Isoflavones for the Treatment of Retroviral Infection, US patent. 2015.
Tan Z., ZHOU J., Cheung K.L.A., Yu Z., Cheung K.W., Liang J., Wang H., LEE B.K., Man K., Liu L., Yuen K.Y. and Chen Z., Vaccine-Elicited CD8+ T Cells Cure Mesothelioma by Overcoming Tumor-Induced Immunosuppressive Environment, Cancer Research. 2014, 74: 6010-6021.
WU H., ZHANG X., Zhang H.J., Zhang Q., Chen Z., Huang J., Lee S.S. and Zheng B., In Vitro Selection of HIV-1 CRF08_BC Variants Resistant to Reverse Transcriptase Inhibitors , AIDS Research and Human Retroviruses. 2015, 31: 260-270.
ZHANG X., WU H., Zhang Q., Lau T.C.K., Chu H., Chen Z., Jin D. and Zheng B., A novel mutation, D404N, in the connection subdomain of reverse transcriptase of HIV-1 CRF08_BC subtype confers cross-resistance to NNRTIs, Journal of Antimicrobial Chemotherapy. 2015.
Zhang Y.I.N.F.E.N.G., Li S.I.A.-.K.A.M., Yang Y.I., Liu M.I.N.G.H.U.A., Lee N.E.I.S.O.N., Tang X.I.A.N., Wang H., Liu L., Chen Z., Zhang C., Wang J. and Tsui K.Y., Whole genome methylation array reveals the down-regulation of IGFBP6 and SATB2 by HIV-1, Scientific Reports. 2015, 5: 10806.


Researcher : Cheng VCC

List of Research Outputs

CHUI S.L.C., Man K.C.K., Cheng C.L., LAU C.Y., Cheng V.C.C., Wong D.S.H., Yan-Kao Y.H. and Wong I.C.K., An investigation of the association between retinal detachment and oral fluoroquinolones: a self-controlled case series study. , International Society of Pharmacovigilance XIII meeting, Pisa, October 1-4 International Society for Pharmacoepidemiology (ISPE) 8th Asian Conference on Pharmacoepidemiology; The University of Hong Kong, 25-27 October. 2014.
Chan J.F.W., Lau S.K.P., Wong S.C.Y., To K.K.W., Cheng V.C.C. and Yuen K.Y., Comparative analysis of patients with chronic pulmonary aspergillosis and invasive pulmonary aspergillosis: a ten-year retrospective study, 25th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2015), European Society of Clinical Microbiology and Infectious Diseases, Copenhagen, Denmark. 2015.
Chan J.F.W., Lau S.K.P., To K.K.W., Cheng V.C.C., Woo P.C.Y. and Yuen K.Y., Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease, Clinical Microbiology Reviews. 2015, 28: 465-522.
Chen J.H.K., She K.K.K., Wong O.Y., Teng L.L., Yam W.C., Lau S.K.P., Woo P.C.Y., Cheng V.C.C. and Yuen K.Y., Use of MALDI Biotyper plus ClinProTools mass spectra analysis for correct identification of Streptococcus pneumoniae and Streptococcus mitis / oralis , Journal of Clinical Pathology. 2015, jclinpath-2014-202818.
Cheng V.C.C., Chen J.H.K., Poon R.W.S., Lee W.M., So S.Y.C., Wong S.C.Y., Chau P.H., Yip C.Y., Wong S.S.Y., Chan J.F.W., Hung I.F.N., Ho P.L. and Yuen K.Y., Control of hospital endemicity of multiple-drug-resistant Acinetobacter baumannii ST457 with directly observed hand hygiene, European Journal of Clinical Microbiology & Infectious Diseases. 2015, 34: 713-718.
Cheng V.C.C., Chen J.H.K., Tai J.W.M., Wong S.C.Y., Poon W.S.R., Hung I.F.N., Chan J.F.W., Ho P.L., Lo C.M. and Yuen K.Y., Decolonization of gastrointestinal carriage of vancomycin-resistant Enterococcus faecium: case series and review of literature, BMC Infectious Diseases. 2014, 14: 514.
Cheng V.C.C., Tai J.W., Lee W.M., Chan W.M., Wong S.C.Y., Chen J.H.K., Poon W.S.R., To K.K.W., Chan J.F.W., Ho P.L., Chan K.H. and Yuen K.Y., Infection Control Preparedness for Human Infection With Influenza A H7N9 in Hong Kong, Infection Control & Hospital Epidemiology. 2015, 36: 87-92.
Ho P.L., LEUNG M.H., Chow K.H., Tse C.W., Cheng V.C.C., Tse H., Mak S.K. and Lo W.K., Carriage niches and molecular epidemiology of Staphylococcus lugdunensis and methicillin-resistant S. lugdunensis among patients undergoing long-term renal replacement therapy, Diagnostic Microbiology and Infectious Disease. 2015, 81: 141-144.
Ho P.L., Chu Y.P., Lo W.U., Chow K.H., LAW Y.T., Tse C.W., Ng T.K., Cheng V.C.C. and Que T.L., High prevalence of Escherichia coli sequence type 131 among antimicrobial-resistant E. coli isolates from geriatric patients, Journal of Medical Microbiology. 2015, 64: 243-247.
Ho P.L., LEUNG M.H., Tse H., Chow K.H., Cheng V.C.C. and Que T.L., Novel Selective Medium for Isolation of Staphylococcus lugdunensis from Wound Specimens, Journal of Clinical Microbiology. 2014, 52: 2633-2636.
Ho P.L., Sin W.C., Chan J.F.W., Cheng V.C.C. and Chan K.H., Severe influenza A H7N9 pneumonia with rapid virological response to intravenous zanamivir, European Respiratory Journal. 2014, 44: 535-537.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Best Abstract in Clinical Medicine (Oral) - "Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial", 20th Medical Research Conference 2015, Department of Medicine, The University of Hong Kong . 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial, 20th Medical Research Conference, The University of Hong Kong, 17 Jan 2015. (Oral presentation - Best abstract in Clinical Medicine) . 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial, Clinical Infectious Diseases . 2014, 59(9): 1246-55.
Luo Y., Siu G.K.H., Yeung A.S.F., Chen J.H.K., Ho P.L., Leung K.W., Tsang L.Y., Cheng V.C.C., Guo L., Yang J., Ye L. and Yam W.C., Performance of the VITEK MS matrix-assisted laser desorption ionization-time of flight mass spectrometry system for rapid bacterial identification in two diagnostic centres in China, Journal of Medical Microbiology. 2015, 64: 18-24.
To K.K.W., Tse H., Chan W.M., CHOI K.Y., Zhang J., Sridhar S., Wong S.C.Y., Chan J.F.W., Chan S.F., Woo P.C.Y., Lau S.K.P., Lo J.Y., Chan K.H., Cheng V.C.C. and Yuen K.Y., A novel psittacine adenovirus identified during an outbreak of avian chlamydiosis and human psittacosis: zoonosis associated with virus-bacterium coinfection in birds, PLoS Neglected Tropical Diseases. 2014, 8: e3318.
To K.K.W., Chan J.F.W., Tsang K.L., Cheng V.C.C. and Yuen K.Y., Ebola virus disease: a highly fatal infectious disease reemerging in West Africa, Microbes and Infection. 2015, 17: 84-97.


Researcher : Cheung CY

Project Title:Biomarkers & Diagnostics World Congress; Diagnosis and assessment of severity in respiratory infectious diseases using host gene expression profiles
Investigator(s):Cheung CY
Department:School of Public Health
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:05/2013


List of Research Outputs

LEUNG H.C., Chan C.S., Poon K.M., ZHAO H., Cheung C.Y., Ng F., Huang J. and Zheng B., An H5N1-based matrix protein 2 ectodomain tetrameric peptide vaccine provides cross-protection against lethal infection with H7N9 influenza virus, Emerging Microbes & Infections. 2015, 4: e22.


Researcher : Cheung KLA

Project Title:Human cytomegalovirus and human immunodeficiency virus type 1 co-infection of CD34+ Myeloid Progenitor Cells
Investigator(s):Cheung KLA, Chen Z
Department:LKS Medical Faculty
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2013


Project Title:Transfer of HIV-1 from HIV-1 latently infected CD34+ hematopoietic progenitors to CD4+ T cells
Investigator(s):Cheung KLA, Chen Z
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:02/2014


Project Title:Downstream signaling pathways involved in Δ42PD1 cytokine induction
Investigator(s):Cheung KLA, Chen Z
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:06/2015


List of Research Outputs

Cheng L., Tang X., Liu L., PENG J., Nishiura K., Cheung K.L.A., GUO J., WU X., Tang H., An M., ZHOU J., Cheung K.W., Wang H., Guan X., Wu Z. and Chen Z., Monoclonal antibodies specific to human Δ42PD1: A novel immunoregulator potentially involved in HIV-1 and tumor pathogenesis, mAbs. 2015, 7: 620-629.
Tan Z., ZHOU J., Cheung K.L.A., Yu Z., Cheung K.W., Liang J., Wang H., LEE B.K., Man K., Liu L., Yuen K.Y. and Chen Z., Vaccine-Elicited CD8+ T Cells Cure Mesothelioma by Overcoming Tumor-Induced Immunosuppressive Environment, Cancer Research. 2014, 74: 6010-6021.


Researcher : Cheung KW

Project Title:Type of cell death and related mechanisms for gut homing CD4 T cells during human immunodeficiency virus-1 (HIV-1) infection
Investigator(s):Cheung KW, Chen Z
Department:LKS Medical Faculty
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:03/2013


Project Title:Role of microvesicles released by HIV-1 infected gut homing CD4 T cells in AIDS pathogenesis
Investigator(s):Cheung KW, Chen Z
Department:LKS Medical Faculty
Source(s) of Funding:Small Project Funding
Start Date:05/2014


List of Research Outputs

Cheng L., Tang X., Liu L., PENG J., Nishiura K., Cheung K.L.A., GUO J., WU X., Tang H., An M., ZHOU J., Cheung K.W., Wang H., Guan X., Wu Z. and Chen Z., Monoclonal antibodies specific to human Δ42PD1: A novel immunoregulator potentially involved in HIV-1 and tumor pathogenesis, mAbs. 2015, 7: 620-629.
LIANG J., Liu L., Chen M.A.N.D.Y., Li M.A.N.-.P.O., Li C.H.U.N.-.H.O., Chan C.H.U.N.-.C.H.U.N.G., TANG X., PENG J., Cheung K.W., Yam W.C. and Chen Z., Community-based HIV-1 Early Diagnosis and Risk Behavior Analysis of Men Having Sex with Men in Hong Kong, PLOS one. 2015, Apr 27;10: 4.
Tan Z., ZHOU J., Cheung K.L.A., Yu Z., Cheung K.W., Liang J., Wang H., LEE B.K., Man K., Liu L., Yuen K.Y. and Chen Z., Vaccine-Elicited CD8+ T Cells Cure Mesothelioma by Overcoming Tumor-Induced Immunosuppressive Environment, Cancer Research. 2014, 74: 6010-6021.


Researcher : Chow KH

List of Research Outputs

Ho P.L., LEUNG M.H., Chow K.H., Tse C.W., Cheng V.C.C., Tse H., Mak S.K. and Lo W.K., Carriage niches and molecular epidemiology of Staphylococcus lugdunensis and methicillin-resistant S. lugdunensis among patients undergoing long-term renal replacement therapy, Diagnostic Microbiology and Infectious Disease. 2015, 81: 141-144.
Ho P.L., Lo W.U., Lai E.L.Y., LAW Y.T., LEUNG M.H., WANG Y. and Chow K.H., Clonal diversity of CTX-M-producing, multidrug-resistant Escherichia coli from rodents, Journal of Medical Microbiology. 2015, 64: 185-190.
Ho P.L., Chu Y.P., Lo W.U., Chow K.H., LAW Y.T., Tse C.W., Ng T.K., Cheng V.C.C. and Que T.L., High prevalence of Escherichia coli sequence type 131 among antimicrobial-resistant E. coli isolates from geriatric patients, Journal of Medical Microbiology. 2015, 64: 243-247.
Ho P.L., Chiu S.S.S., LAW Y.T., Chan L.Y., Lai E.L.Y. and Chow K.H., Increase in the nasopharyngeal carriage of non-vaccine serogroup 15 Streptococcus pneumoniae after introduction of children pneumococcal conjugate vaccination in Hong Kong, Diagnostic Microbiology and Infectious Disease. 2015, 81: 145-148.
Ho P.L., LEUNG M.H., Tse H., Chow K.H., Cheng V.C.C. and Que T.L., Novel Selective Medium for Isolation of Staphylococcus lugdunensis from Wound Specimens, Journal of Clinical Microbiology. 2014, 52: 2633-2636.
Ho P.L., Liu C., Lo W.U., Lai E.L.Y., Lau T.C., Law O.K. and Chow K.H., Prevalence and characterization of hybrid blaCTX-M among Escherichia coli isolates from livestock and other animals, Diagnostic Microbiology and Infectious Disease. 2015, 82: 148-153.
Ho P.L., Leung L.M., Chow K.H., Lai E.L.Y., Lo W.U. and Ng T.K., Prevalence of aminoglycoside modifying enzyme and 16S ribosomal RNA methylase genes among aminoglycoside-resistant Escherichia coli isolates, Journal of Microbiology, Immunology and Infection. 2014.
WANG Y..., Lo W.U., Lai E.L.Y., Chow K.H. and Ho P.L., Complete sequence of a multidrug-resistant IncL/M plasmid pIMP-HB623 co-carrying blaIMP-34 and fosC2 in an Enterobacter cloacae associated with medical travel to China., Antimicrob Agents Chemother. the United States, 2015, pii: AAC.00375-15.
Wu Y., Tu W., Lam K.T., Chow K.H., Ho P.L., Guan Y., Peiris J.S.M. and Lau Y.L., Lethal coinfection of influenza virus and Streptococcus pneumoniae lowers antibody response to influenza virus in lung and reduces numbers of germinal center B cells, T follicular helper cells, and plasma cells in mediastinal lymph Node., Journal of Virology. 2015, 89(4): 2013-23.


Researcher : Chow WN

List of Research Outputs

Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Lau C.Y., Chow W.N., Ngan A.H., To K.K.W., Chan J.F.W., Hung I.F.N., Yam W.C., Yuen K.Y. and Woo P.C.Y., Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics: exploration of potential biomarkers, Emerging Microbes & Infections. 2015, 4: e6.
Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Lau C.Y., Chow W.N., Ngan A.H., To K.K.W., Chan J.F.W., Hung I.F.N., Yam W.C., Yuen K.Y. and Woo P.C.Y., Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics: exploration of potential biomarkers, Emerging Microbes and Infections. 2015, 4: e6.
Lau S.K.P., Sridhar S., Ho C.C., Chow W.N., Lee K.C., Lam C.W., Yuen K.Y. and Woo P.C.Y., Laboratory diagnosis of melioidosis: Past, present and future, Experimental Biology and Medicine. 2015, 240: 742-751.
Yang E., Chow W.N., Wang G., Woo P.C.Y., Lau S.K.P., Yuen K.Y., Lin X. and Cai J.J., Signature gene expression reveals novel clues to the molecular mechanisms of dimorphic transition in Penicillium marneffei, PLoS Genetics. 2014, 10: e1004662.


Researcher : Chu H

Project Title:Investigating the outcome of MERS-CoV infection in human peripheral blood mononuclear cells.
Investigator(s):Chu H, Yuen KY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:12/2014


List of Research Outputs

CHENG Z., Zhou J., To K.K.W., Chu H., Li C., Song Y., Zheng B. and Yuen K.Y., Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza., Journal of Infectious Diseases. 2015.
ZHANG X., WU H., Zhang Q., Lau T.C.K., Chu H., Chen Z., Jin D. and Zheng B., A novel mutation, D404N, in the connection subdomain of reverse transcriptase of HIV-1 CRF08_BC subtype confers cross-resistance to NNRTIs, Journal of Antimicrobial Chemotherapy. 2015.


Researcher : Curreem SOT

List of Research Outputs

Lau S.K.P., Chan S.Y., Curreem S.O.T., Hui S.W., Lau C.Y., Lee P., Ho C.C., Martelli P. and Woo P.C.Y., Burkholderia pseudomallei in soil samples from an oceanarium in Hong Kong detected using a sensitive PCR assay, Emerging Microbes and Infections. 2014, 3: e69.
Lau S.K.P., Teng L.L., Huang Y., Curreem S.O.T., Tsui S.K. and Woo P.C.Y., Draft Genome Sequence of Catabacter hongkongensis type strain HKU16T isolated from a patient with bacteremia and intestinal obstruction, Genome Announcements. 2015, 3: e00531-15.
Lau S.K.P., Wu A.K.L., Teng L.L., Tse H., Curreem S.O.T., Tsui S.K.W., Huang Y., Chen J.H.K., Lee R.A., Yuen K.Y. and Woo P.C.Y., Evidence for Elizabethkingia anophelis transmission from mother to infant, Hong Kong., Emerging Infectious Diseases. 2015, 21: 232-241.
Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Lau C.Y., Chow W.N., Ngan A.H., To K.K.W., Chan J.F.W., Hung I.F.N., Yam W.C., Yuen K.Y. and Woo P.C.Y., Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics: exploration of potential biomarkers, Emerging Microbes & Infections. 2015, 4: e6.
Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Lau C.Y., Chow W.N., Ngan A.H., To K.K.W., Chan J.F.W., Hung I.F.N., Yam W.C., Yuen K.Y. and Woo P.C.Y., Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics: exploration of potential biomarkers, Emerging Microbes and Infections. 2015, 4: e6.
Woo P.C.Y., Wu A.K., TSANG C.C., Leung K.W., Ngan A.H., Curreem S.O.T., Lam K.W., Chen J.H.K., Chan J.F.W. and Lau S.K.P., Streptobacillus hongkongensis sp. nov., isolated from patients with quinsy and septic arthritis in Hong Kong and emended descriptions of the genus Streptobacillus and the species Streptobacillus moniliformis, International Journal of Systematic and Evolutionary Microbiology. 2014, 64: 3034-3039.


Researcher : Dai J

List of Research Outputs

CHEUNG N.N., Dai J., LAI K.K., YANG F. and Kao R.Y.T., Best Student Poster Award "Identification of a broad-spectrum inhibitor of common RNA respiratory viruses by high-throughput screening", The 28th International Conference on Antiviral Research (ICAR). 2015.


Researcher : Fan YY

List of Research Outputs

Lau S.K.P., Woo P.C.Y., Yip C.Y., Li K.S.M., Fan Y.Y., BAI R., Huang Y., Chan K.H. and Yuen K.Y., Chickens host diverse picornaviruses originated from potential interspecies transmission with recombination, Journal of General Virology. 2014, 95: 1929-1944.
Lau S.K.P., Woo P.C.Y., Li K.S.M., Tsang K.L., Fan Y.Y., Luk K.H., Cai J., Chan K.H., Zheng B., Wang M. and Yuen K.Y., Discovery of a novel coronavirus, China Rattus coronavirus HKU24, from Norway rats supports murine origin of Betacoronavirus 1 with implications on the ancestor of Betacoronavirus lineage A, Journal of Virology. 2015, 89: 3076-3092.
Woo P.C.Y., Lau S.K.P., Martelli P., Hui S.W., Lau C.Y., Fan Y.Y., Groff J.M., Tam W.T., Chan K.H. and Yuen K.Y., Fatal systemic necrotizing infections associated with a novel paramyxovirus, anaconda paramyxovirus, in green anaconda juveniles, Journal of Clinical Microbiology. 2014, 52: 3614-3623.


Researcher : GAO P

List of Research Outputs

ZHAO Q., Ding Y., Deng Z.S., Lee O.Y., GAO P., Chen P., Rose R.J., Zhao H., ZHANG Z.F., Tao X., Heck A.J.R., Kao R.Y.T. and Yang D., Natural products triptolide, celastrol, and withaferin A inhibit the chaperone activity of peroxiredoxin I, Chem. Sci.. 2015, 6: 4124-4130.


Researcher : GUO J

List of Research Outputs

Cheng L., Tang X., Liu L., PENG J., Nishiura K., Cheung K.L.A., GUO J., WU X., Tang H., An M., ZHOU J., Cheung K.W., Wang H., Guan X., Wu Z. and Chen Z., Monoclonal antibodies specific to human Δ42PD1: A novel immunoregulator potentially involved in HIV-1 and tumor pathogenesis, mAbs. 2015, 7: 620-629.
GUO J., Zuo T., Cheng L., WU X., TANG J., Sun C.J., Feng L., Chen L., Zhang L.Q. and Chen Z., Simian Immunodeficiency Virus Infection Evades Vaccine-Elicited Antibody Responses to V2 Region, JAIDS Journal of Acquired Immune Deficiency Syndromes. 2015, 68: 502-510.


Researcher : Guan Y

Project Title:Vaccines for the control of H5N1 and other avian influenza viruses
Investigator(s):Guan Y
Department:Microbiology
Source(s) of Funding:The University of Hong Kong Foundation Seed Grant
Start Date:04/2002


Project Title:Searching for the precursor of SARS-Cov in Southern China
Investigator(s):Guan Y
Department:Microbiology
Source(s) of Funding:VCO SARS Research Fund
Start Date:07/2003


Project Title:Partner State Key Laboratory of Emerging Infectious Diseases
Investigator(s):Guan Y
Department:Microbiology
Source(s) of Funding:Matching Fund for State Key Laboratory (SKL)
Start Date:02/2009


Project Title:Infectivity and Transmissibility Study of Avian H9N2 Influenza Viruses in Pigs
Investigator(s):Guan Y, Zhu H, Wang J
Department:School of Public Health
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:10/2012


Project Title:Research Output Prize (Li Ka Shing Faculty of Medicine)
Investigator(s):Guan Y
Department:School of Public Health
Source(s) of Funding:Research Output Prize (in Faculty)
Start Date:01/2013


Project Title:Active influenza surveillance in poultry and humans focused on Guangdong and Zhejiang Provinces
Investigator(s):Guan Y, Zhu H
Department:School of Public Health
Source(s) of Funding:Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential
Start Date:06/2014


Project Title:Outstanding Researcher Award 2013-14
Investigator(s):Guan Y
Department:School of Public Health
Source(s) of Funding:Outstanding Researcher Award
Start Date:12/2014




Researcher : HO CH

List of Research Outputs

Yuen K.S., Chan C.P., Wong N.H.M., HO C.H., HO T.H., Lei T., Deng W., Tsao G.S.W., Chen H., Kok K.H. and Jin D., CRISPR/Cas9-mediated genome editing of Epstein-Barr virus in human cells, Journal of General Virology. 2015, 96: 626-636.


Researcher : HUANG X

List of Research Outputs

Song W., Wang P., Mok B.W.Y., Lau S.Y., HUANG X., Wu W.L., ZHENG M., WEN X., Yang S., Chen Y., Li L., Yuen K.Y. and Chen H., The K526R substitution in viral protein ​PB2 enhances the effects of E627K on influenza virus replication, Nature Communications. 2014.


Researcher : Ho PL

Project Title:A phenotypic and genotypic analysis of vancomycin tolerance in Streptococcus pnemoniae
Investigator(s):Ho PL, Yuen KY, Que TL
Department:Microbiology
Source(s) of Funding:Low Budget High Impact Programme
Start Date:11/2000


Project Title:Molecular epidemiology of fluoroquinolone-resistant streptococcus pneumoniae in Hong kong and Canada
Investigator(s):Ho PL
Department:Microbiology
Source(s) of Funding:Low Budget High Impact Programme
Start Date:11/2001


Project Title:Risk factors for SARS in health care workers following incubation of SARS patients
Investigator(s):Ho PL, Hung CT
Department:Microbiology
Source(s) of Funding:VCO SARS Research Fund
Start Date:07/2003


Project Title:Fluoroquinolone susceptibility clinical breakpoints and fluoroquinolone-resistant determining mutations among clinical strains of streptococcus pneumoniae
Investigator(s):Ho PL, Wong SSY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:11/2003


Project Title:Evaluation of molecular tests for the rapid detection of rifampicin and isoniazid resistance in Mycobacterium tuberculosis and their impact on patient management
Investigator(s):Ho PL, Yam WC, Leung CC, Yew WW, Mok YW, Chan KS, Tam CM
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:04/2006


Project Title:Syndromic Surveillance and Modeling for Infectious Diseases
Investigator(s):Ho PL, Wu JTK
Department:Microbiology
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2013


Project Title:Molecular epidemiology of transferrable multidrug-resistant pump oqxAB in Escherichia coli from human and animal sources
Investigator(s):Ho PL, Lo WU
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:06/2015


List of Research Outputs

Cheng V.C.C., Chen J.H.K., Poon R.W.S., Lee W.M., So S.Y.C., Wong S.C.Y., Chau P.H., Yip C.Y., Wong S.S.Y., Chan J.F.W., Hung I.F.N., Ho P.L. and Yuen K.Y., Control of hospital endemicity of multiple-drug-resistant Acinetobacter baumannii ST457 with directly observed hand hygiene, European Journal of Clinical Microbiology & Infectious Diseases. 2015, 34: 713-718.
Cheng V.C.C., Chen J.H.K., Tai J.W.M., Wong S.C.Y., Poon W.S.R., Hung I.F.N., Chan J.F.W., Ho P.L., Lo C.M. and Yuen K.Y., Decolonization of gastrointestinal carriage of vancomycin-resistant Enterococcus faecium: case series and review of literature, BMC Infectious Diseases. 2014, 14: 514.
Cheng V.C.C., Tai J.W., Lee W.M., Chan W.M., Wong S.C.Y., Chen J.H.K., Poon W.S.R., To K.K.W., Chan J.F.W., Ho P.L., Chan K.H. and Yuen K.Y., Infection Control Preparedness for Human Infection With Influenza A H7N9 in Hong Kong, Infection Control & Hospital Epidemiology. 2015, 36: 87-92.
Chiu S.S.S., Ho P.L., Peiris J.S.M., Chan K.H. and Chan L.Y., Population-based hospitalization incidence of respiratory viruses in community-acquired pneumonia in children younger than 5 years of age, Influenza and Other Respiratory Viruses. 2014, 8(6): 626-7.
Chiu S.S.S., Ho P.L., Khong P.L., Ooi C.G.C., So L.Y., Wong W.H.S. and Chan L.Y., Population-based incidence of community-acquired pneumonia hospitalization in Hong Kong children younger than 5 years before universal conjugate pneumococcal immunization. , Journal of Microbiology, Immunology and Infection. 2014.
Ho P.L., LEUNG M.H., Chow K.H., Tse C.W., Cheng V.C.C., Tse H., Mak S.K. and Lo W.K., Carriage niches and molecular epidemiology of Staphylococcus lugdunensis and methicillin-resistant S. lugdunensis among patients undergoing long-term renal replacement therapy, Diagnostic Microbiology and Infectious Disease. 2015, 81: 141-144.
Ho P.L., Lo W.U., Lai E.L.Y., LAW Y.T., LEUNG M.H., WANG Y. and Chow K.H., Clonal diversity of CTX-M-producing, multidrug-resistant Escherichia coli from rodents, Journal of Medical Microbiology. 2015, 64: 185-190.
Ho P.L., Chu Y.P., Lo W.U., Chow K.H., LAW Y.T., Tse C.W., Ng T.K., Cheng V.C.C. and Que T.L., High prevalence of Escherichia coli sequence type 131 among antimicrobial-resistant E. coli isolates from geriatric patients, Journal of Medical Microbiology. 2015, 64: 243-247.
Ho P.L., Chiu S.S.S., LAW Y.T., Chan L.Y., Lai E.L.Y. and Chow K.H., Increase in the nasopharyngeal carriage of non-vaccine serogroup 15 Streptococcus pneumoniae after introduction of children pneumococcal conjugate vaccination in Hong Kong, Diagnostic Microbiology and Infectious Disease. 2015, 81: 145-148.
Ho P.L., Yam W.C., Leung C.C., Yew W.W., Mok T.Y., Chan K.S. and Tam C.M., Molecular tests for rapid detection of rifampicin and isoniazid resistance in Mycobacterium tuberculosis., Hong Kong Med J. 2015.
Ho P.L., LEUNG M.H., Tse H., Chow K.H., Cheng V.C.C. and Que T.L., Novel Selective Medium for Isolation of Staphylococcus lugdunensis from Wound Specimens, Journal of Clinical Microbiology. 2014, 52: 2633-2636.
Ho P.L., Liu C., Lo W.U., Lai E.L.Y., Lau T.C., Law O.K. and Chow K.H., Prevalence and characterization of hybrid blaCTX-M among Escherichia coli isolates from livestock and other animals, Diagnostic Microbiology and Infectious Disease. 2015, 82: 148-153.
Ho P.L., Leung L.M., Chow K.H., Lai E.L.Y., Lo W.U. and Ng T.K., Prevalence of aminoglycoside modifying enzyme and 16S ribosomal RNA methylase genes among aminoglycoside-resistant Escherichia coli isolates, Journal of Microbiology, Immunology and Infection. 2014.
Ho P.L., Sin W.C., Chan J.F.W., Cheng V.C.C. and Chan K.H., Severe influenza A H7N9 pneumonia with rapid virological response to intravenous zanamivir, European Respiratory Journal. 2014, 44: 535-537.
Hui W.S., Ho S.P., Wong A.T., Ho P.L. and Mak J.C.W., Cellular signaling pathways of matrix metalloproteinase gene expression by Pseudomonas aeruginosa-infected human bronchial epithelial cells, Hong Kong Med J. 2014, 20: 14-17.
Leung C.C., Yam W.C., Ho P.L., Yew W.W., Chan C.K., Law W.S., Lee S.N., Chang K.C., Tai L.B. and Tam C.M., T-Spot. TB outperforms tuberculin skin test in predicting development of active tuberculosis among household contacts , Respirology. 2015, 20: 496-503.
Luo Y., Siu G.K.H., Yeung A.S.F., Chen J.H.K., Ho P.L., Leung K.W., Tsang L.Y., Cheng V.C.C., Guo L., Yang J., Ye L. and Yam W.C., Performance of the VITEK MS matrix-assisted laser desorption ionization-time of flight mass spectrometry system for rapid bacterial identification in two diagnostic centres in China, Journal of Medical Microbiology. 2015, 64: 18-24.
WANG Y..., Lo W.U., Lai E.L.Y., Chow K.H. and Ho P.L., Complete sequence of a multidrug-resistant IncL/M plasmid pIMP-HB623 co-carrying blaIMP-34 and fosC2 in an Enterobacter cloacae associated with medical travel to China., Antimicrob Agents Chemother. the United States, 2015, pii: AAC.00375-15.
Wu J.T.K., Lee C.K., Ho P.L., Hung I.F.N., Lin C.K., Lau Y.L., Leung G.M., Cowling B.J. and Peiris J.S.M., A Detailed Longitudinal Study of Infection Attack Rates Among Healthy Adults in Hong Kong During the Epidemic of the Human Swine Influenza A/H1N1 Virus in 2009, Health Research Symposium 2014, Hong Kong, 15 Nov 2014. (Poster presentation). 2014.
Wu Y., Tu W., Lam K.T., Chow K.H., Ho P.L., Guan Y., Peiris J.S.M. and Lau Y.L., Lethal coinfection of influenza virus and Streptococcus pneumoniae lowers antibody response to influenza virus in lung and reduces numbers of germinal center B cells, T follicular helper cells, and plasma cells in mediastinal lymph Node., Journal of Virology. 2015, 89(4): 2013-23.


Researcher : Im SWK

Project Title:Investigation of community exposure to a novel coronavirus associated with SARS and herd immunity developed among healthy blood donors
Investigator(s):Im SWK, Yam WC
Department:Microbiology
Source(s) of Funding:VCO SARS Research Fund
Start Date:07/2003




Researcher : Kao RYT

Project Title:Mode of action of a lead anti-influenza compound identified by chemical genetics
Investigator(s):Kao RYT
Department:Microbiology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2006


Project Title:Cloning and characterization of Streptococcus pneumoniae methionine aminopeptidase: a potential target for antimicrobial therapies
Investigator(s):Kao RYT
Department:Microbiology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2007


Project Title:Direct binding of influenza A nuceloprotein (NP) to a novel NP nuclear export inhibitor
Investigator(s):Kao RYT, Sze KH
Department:Microbiology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2014


Project Title:The 28th International Conference on Antiviral Research; An induced-fit binding model for nucleozin-mediated influenza A nucleoprotein (NP) aggregation
Investigator(s):Kao RYT
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:05/2015


List of Research Outputs

CHEUNG N.N., Dai J., LAI K.K., YANG F. and Kao R.Y.T., Best Student Poster Award "Identification of a broad-spectrum inhibitor of common RNA respiratory viruses by high-throughput screening", The 28th International Conference on Antiviral Research (ICAR). 2015.
CHOI C.K., HO D.N., Hui K.F., Kao R.Y.T. and Chiang A.K.S., Identification of novel small organic compounds for induction of Epstein-Barr virus (EBV) lytic cycle in EBV-positive epithelial malignancies, 16th International Symposium on EBV and Associated Diseases. 2014.
LAI T.P., WANG R., Zhang H., Kao R.Y.T. and Sun H., Characterization of Metallodrugs Binding to NDM-1 Offers New Insight into Ways of Overcoming Antibiotic Resistance, The 5th Asian Conference on Coordination Chemistry (ACCC-5), Hong Kong, July 12-16, 2014.
SUN Y., Tsui Y.K., Kao R.Y.T., Chan D., Cheung K.M.C. and Leung V.Y.L., Screening Small Molecule Inhibitors Against Proteoglycan Degradation To Control Tissue Degeneration, 9th International Conference on Proteoglycans and 10th Pan-Pacific Connective Tissue Societies Symposium(ICP&PPCTSS 2015). 2015.
Siu G.K.H., Yam W.C., Zhang Y. and Kao R.Y.T., An Upstream Truncation of the furA-katG Operon Confers High-Level Isoniazid Resistance in a Mycobacterium tuberculosis Clinical Isolate with No Known Resistance-Associated Mutations, Antimicrobial Agents and Chemotherapy. 2014, 58: 6093-6100.
ZHAO Q., Ding Y., Deng Z.S., Lee O.Y., GAO P., Chen P., Rose R.J., Zhao H., ZHANG Z.F., Tao X., Heck A.J.R., Kao R.Y.T. and Yang D., Natural products triptolide, celastrol, and withaferin A inhibit the chaperone activity of peroxiredoxin I, Chem. Sci.. 2015, 6: 4124-4130.
Zhang B., HUA Y., Yu B., Lau C.Y., Cai J., Zheng S.Y., Yam W.C., Kao R.Y.T., Sze K.H., Zheng B., Yuen K.Y. and Huang J., Recombinant ESAT-6-Like Proteins Provoke Protective Immune Responses against Invasive Staphylococcus aureus Disease in a Murine Model, Infection and Immunity. 2015, 83: 339-345.


Researcher : Ke Y

List of Research Outputs

To K.K.W., Lee K.C., Wong S.S.Y., Lo K.C., Lui Y.M., Akhee S.J., Wu L., Ke Y., Law C.Y., Sze K.H., Lau S.K.P., Woo P.C.Y., Lam C.W. and Yuen K.Y., Lipid mediators of inflammation as novel plasma biomarkers to identify patients with bacteremia, Journal of Infection. 2015, 70: 433-444.


Researcher : Kok KH

Project Title:Identification of a novel splice isoform of TRBP and characterization of its role in microRNA biogenesis
Investigator(s):Kok KH, Wong CM
Department:Biochemistry
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2012


Project Title:Mechanistic study of the roles of PACT in MDA5-mediated innate antiviral immunity
Investigator(s):Kok KH, Chan CP
Department:Biochemistry
Source(s) of Funding:National Natural Science Foundation of China (NSFC) - General Program
Start Date:01/2013


Project Title:Role of PACT in host antiviral defence against influenza A virus
Investigator(s):Kok KH
Department:Biochemistry
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2013


Project Title:Roles of PACT in the induction of type I interferon by measles virus defective interring RNA
Investigator(s):Kok KH
Department:Biochemistry
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2013


Project Title:Characterization of an alternatively spliced tumor suppressor FAT1 in hepatocellular carcinoma
Investigator(s):Kok KH
Department:Biochemistry
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2014


Project Title:The 16th International Symposium on EBV and Associated Diseases; Modulation of innate antiviral response by a single Epstein-Barr virus-encoded microRNA
Investigator(s):Kok KH
Department:Biochemistry
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:07/2014
Completion Date:07/2014


Project Title:Suppression of PACT-dependent antiviral response by measles virus V protein
Investigator(s):Kok KH
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:03/2015


List of Research Outputs

Chan C.P., Lui P.Y., FUNG S.Y. and Kok K.H., PACT targeting is a novel viral strategy of innate immune evasion, The 9th Chinese Society for Immunology Symposium. 2014.
KEW C., Siu K.L., Chan C.P. and Kok K.H., Viral suppression of type I interferon production through PACT targeting, The Yin & Yang of the Interferon System. International Cytokine and Interferon Society Satellite Symposium. 2014.
Tang H.M.V., Gao W., Chan C.P., Cheng Y., Chaudhary V., Deng J., Yuen K.S., Wong C.M., Ng I.O.L., Kok K.H., Zhou J. and Jin D., Requirement of CRTC1 coactivator for hepatitis B virus transcription, Nucleic Acids Res. 2014, 42(20): 12455-68.
Wong L.W.M., YUEN C.K. and Kok K.H., Innate recognition of Sendai virus defective-interfering RNA, 12th International Conference on Innate Immunity. 2015.
Yuen K.S., Chan C.P., Wong N.H.M., HO C.H., HO T.H., Lei T., Deng W., Tsao G.S.W., Chen H., Kok K.H. and Jin D., CRISPR/Cas9-mediated genome editing of Epstein-Barr virus in human cells, Journal of General Virology. 2015, 96: 626-636.
Yuen K.S., Lei T., Kok K.H. and Jin D., Role of Epstein-Barr virus-encoded BART microRNAs in viral infection and transformation of nasopharyngeal epithelial cells, The Croucher Foundation Advanced Study Institute on “Advances in Nasopharyngeal Carcinoma Studies”.. 2014.


Researcher : LAI KK

List of Research Outputs

CHEUNG N.N., Dai J., LAI K.K., YANG F. and Kao R.Y.T., Best Student Poster Award "Identification of a broad-spectrum inhibitor of common RNA respiratory viruses by high-throughput screening", The 28th International Conference on Antiviral Research (ICAR). 2015.


Researcher : LAW YT

List of Research Outputs

Ho P.L., Lo W.U., Lai E.L.Y., LAW Y.T., LEUNG M.H., WANG Y. and Chow K.H., Clonal diversity of CTX-M-producing, multidrug-resistant Escherichia coli from rodents, Journal of Medical Microbiology. 2015, 64: 185-190.
Ho P.L., Chu Y.P., Lo W.U., Chow K.H., LAW Y.T., Tse C.W., Ng T.K., Cheng V.C.C. and Que T.L., High prevalence of Escherichia coli sequence type 131 among antimicrobial-resistant E. coli isolates from geriatric patients, Journal of Medical Microbiology. 2015, 64: 243-247.
Ho P.L., Chiu S.S.S., LAW Y.T., Chan L.Y., Lai E.L.Y. and Chow K.H., Increase in the nasopharyngeal carriage of non-vaccine serogroup 15 Streptococcus pneumoniae after introduction of children pneumococcal conjugate vaccination in Hong Kong, Diagnostic Microbiology and Infectious Disease. 2015, 81: 145-148.


Researcher : LEE BK

List of Research Outputs

Tan Z., ZHOU J., Cheung K.L.A., Yu Z., Cheung K.W., Liang J., Wang H., LEE B.K., Man K., Liu L., Yuen K.Y. and Chen Z., Vaccine-Elicited CD8+ T Cells Cure Mesothelioma by Overcoming Tumor-Induced Immunosuppressive Environment, Cancer Research. 2014, 74: 6010-6021.


Researcher : LEUNG HC

List of Research Outputs

LEUNG H.C., Chan C.S., Poon K.M., ZHAO H., Cheung C.Y., Ng F., Huang J. and Zheng B., An H5N1-based matrix protein 2 ectodomain tetrameric peptide vaccine provides cross-protection against lethal infection with H7N9 influenza virus, Emerging Microbes & Infections. 2015, 4: e22.


Researcher : LEUNG MH

List of Research Outputs

Ho P.L., LEUNG M.H., Chow K.H., Tse C.W., Cheng V.C.C., Tse H., Mak S.K. and Lo W.K., Carriage niches and molecular epidemiology of Staphylococcus lugdunensis and methicillin-resistant S. lugdunensis among patients undergoing long-term renal replacement therapy, Diagnostic Microbiology and Infectious Disease. 2015, 81: 141-144.
Ho P.L., Lo W.U., Lai E.L.Y., LAW Y.T., LEUNG M.H., WANG Y. and Chow K.H., Clonal diversity of CTX-M-producing, multidrug-resistant Escherichia coli from rodents, Journal of Medical Microbiology. 2015, 64: 185-190.
Ho P.L., LEUNG M.H., Tse H., Chow K.H., Cheng V.C.C. and Que T.L., Novel Selective Medium for Isolation of Staphylococcus lugdunensis from Wound Specimens, Journal of Clinical Microbiology. 2014, 52: 2633-2636.


Researcher : LI C

List of Research Outputs

CHENG Z., Zhou J., To K.K.W., Chu H., Li C., Song Y., Zheng B. and Yuen K.Y., Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza., Journal of Infectious Diseases. 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Best Abstract in Clinical Medicine (Oral) - "Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial", 20th Medical Research Conference 2015, Department of Medicine, The University of Hong Kong . 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial, 20th Medical Research Conference, The University of Hong Kong, 17 Jan 2015. (Oral presentation - Best abstract in Clinical Medicine) . 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial, Clinical Infectious Diseases . 2014, 59(9): 1246-55.
Li C., Li C., Zhang J., To K.K.W., Lee C.Y., Zhu H., Wu W.L., Chan J.F.W., Chen H., Hung I.F.N., Li L. and Yuen K.Y., Avian Influenza A H7N9 Virus Induces Severe Pneumonia in Mice without Prior Adaptation and Responds to a Combination of Zanamivir and COX-2 Inhibitor , PLoS One. 2014, 9(9): e107966.
To K.K.W., Zhang J., Chan S.F., LI C., Cai J., Lau C.Y., Li C., Akhee S.J., Wu W.L., Li L., Tsang K.L., Chan K.H., Chen H. and Yuen K.Y., Recombinant influenza A virus hemagglutinin HA2 subunit protects mice against influenza A(H7N9) virus infection, Archives of Virology. 2015, 160: 777-786.


Researcher : LIANG J

List of Research Outputs

LIANG J., Liu L., Chen M.A.N.D.Y., Li M.A.N.-.P.O., Li C.H.U.N.-.H.O., Chan C.H.U.N.-.C.H.U.N.G., TANG X., PENG J., Cheung K.W., Yam W.C. and Chen Z., Community-based HIV-1 Early Diagnosis and Risk Behavior Analysis of Men Having Sex with Men in Hong Kong, PLOS one. 2015, Apr 27;10: 4.
Tan Z., ZHOU J., Cheung K.L.A., Yu Z., Cheung K.W., Liang J., Wang H., LEE B.K., Man K., Liu L., Yuen K.Y. and Chen Z., Vaccine-Elicited CD8+ T Cells Cure Mesothelioma by Overcoming Tumor-Induced Immunosuppressive Environment, Cancer Research. 2014, 74: 6010-6021.


Researcher : Lai ELY

List of Research Outputs

Ho P.L., Lo W.U., Lai E.L.Y., LAW Y.T., LEUNG M.H., WANG Y. and Chow K.H., Clonal diversity of CTX-M-producing, multidrug-resistant Escherichia coli from rodents, Journal of Medical Microbiology. 2015, 64: 185-190.
Ho P.L., Chiu S.S.S., LAW Y.T., Chan L.Y., Lai E.L.Y. and Chow K.H., Increase in the nasopharyngeal carriage of non-vaccine serogroup 15 Streptococcus pneumoniae after introduction of children pneumococcal conjugate vaccination in Hong Kong, Diagnostic Microbiology and Infectious Disease. 2015, 81: 145-148.
Ho P.L., Liu C., Lo W.U., Lai E.L.Y., Lau T.C., Law O.K. and Chow K.H., Prevalence and characterization of hybrid blaCTX-M among Escherichia coli isolates from livestock and other animals, Diagnostic Microbiology and Infectious Disease. 2015, 82: 148-153.
Ho P.L., Leung L.M., Chow K.H., Lai E.L.Y., Lo W.U. and Ng T.K., Prevalence of aminoglycoside modifying enzyme and 16S ribosomal RNA methylase genes among aminoglycoside-resistant Escherichia coli isolates, Journal of Microbiology, Immunology and Infection. 2014.
WANG Y..., Lo W.U., Lai E.L.Y., Chow K.H. and Ho P.L., Complete sequence of a multidrug-resistant IncL/M plasmid pIMP-HB623 co-carrying blaIMP-34 and fosC2 in an Enterobacter cloacae associated with medical travel to China., Antimicrob Agents Chemother. the United States, 2015, pii: AAC.00375-15.


Researcher : Lau CY

List of Research Outputs

Lau S.K.P., Chan S.Y., Curreem S.O.T., Hui S.W., Lau C.Y., Lee P., Ho C.C., Martelli P. and Woo P.C.Y., Burkholderia pseudomallei in soil samples from an oceanarium in Hong Kong detected using a sensitive PCR assay, Emerging Microbes and Infections. 2014, 3: e69.
Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Lau C.Y., Chow W.N., Ngan A.H., To K.K.W., Chan J.F.W., Hung I.F.N., Yam W.C., Yuen K.Y. and Woo P.C.Y., Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics: exploration of potential biomarkers, Emerging Microbes & Infections. 2015, 4: e6.
Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Lau C.Y., Chow W.N., Ngan A.H., To K.K.W., Chan J.F.W., Hung I.F.N., Yam W.C., Yuen K.Y. and Woo P.C.Y., Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics: exploration of potential biomarkers, Emerging Microbes and Infections. 2015, 4: e6.
Lee K.C., Tam W.T., Lo K.C., Tsang K.L., Lau C.Y., To K.K.W., Chan J.F.W., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Metabolomics Analysis Reveals Specific Novel Tetrapeptide and Potential Anti-Inflammatory Metabolites in Pathogenic Aspergillus species, International Journal of Molecular Sciences. 2015, 16: 13850-13867.
To K.K.W., Zhang J., Chan S.F., LI C., Cai J., Lau C.Y., Li C., Akhee S.J., Wu W.L., Li L., Tsang K.L., Chan K.H., Chen H. and Yuen K.Y., Recombinant influenza A virus hemagglutinin HA2 subunit protects mice against influenza A(H7N9) virus infection, Archives of Virology. 2015, 160: 777-786.
Woo P.C.Y., Lau S.K.P., Martelli P., Hui S.W., Lau C.Y., Fan Y.Y., Groff J.M., Tam W.T., Chan K.H. and Yuen K.Y., Fatal systemic necrotizing infections associated with a novel paramyxovirus, anaconda paramyxovirus, in green anaconda juveniles, Journal of Clinical Microbiology. 2014, 52: 3614-3623.
Ying T., Du L., Ju T.W., Prabakaran P., Lau C.Y., Lu L., Liu Q., Wang L., Feng Y. and Wang Y., Exceptionally Potent Neutralization of Middle East Respiratory Syndrome Coronavirus by Human Monoclonal Antibodies, Journal of Virology. 2014, 88: 7796-7805.
Zhang B., HUA Y., Yu B., Lau C.Y., Cai J., Zheng S.Y., Yam W.C., Kao R.Y.T., Sze K.H., Zheng B., Yuen K.Y. and Huang J., Recombinant ESAT-6-Like Proteins Provoke Protective Immune Responses against Invasive Staphylococcus aureus Disease in a Murine Model, Infection and Immunity. 2015, 83: 339-345.


Researcher : Lau S.K.P.

Project Title:The role of bats in the origin of severe acute respiratory syndrome coronavirus
Investigator(s):Lau SKP, Woo PCY, Yuen KY
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:07/2007


Project Title:Genomic and serological characterization of novel animal paramyxoviruses
Investigator(s):Lau SKP, Woo PCY, Yuen KY
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2011
Completion Date:08/2014


Project Title:Matrix-assisted laser desorption ionization time-of-flight mass spectrometry for identification of bacteria that are difficult to identify in clinical laboratories
Investigator(s):Lau SKP, Woo PCY, Teng LL
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:01/2013
Completion Date:12/2014


Project Title:Molecular diversity and evolution of bat group C betacoronaviruses: implications on the origin of the novel human group C betacoronavirus
Investigator(s):Lau SKP, Woo PCY, Zheng B
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:09/2013


Project Title:Molecular evolution and diversity of human coronavirus 229E associated with respiratory tract infections
Investigator(s):Lau SKP, Woo PCY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:01/2014


Project Title:Matrix-assisted laser desorption ionization time-of-flight mass spectrometry for rapid identification of Penicillium marneffei
Investigator(s):Lau SKP, Woo PCY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:01/2015


Project Title:The 15th International Symposium; Emerging coronaviruses: lesson from OC43, SARS to MERS
Investigator(s):Lau SKP
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2015


List of Research Outputs



Researcher : Lau SKP

Project Title:The role of bats in the origin of severe acute respiratory syndrome coronavirus
Investigator(s):Lau SKP, Woo PCY, Yuen KY
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:07/2007


Project Title:Genomic and serological characterization of novel animal paramyxoviruses
Investigator(s):Lau SKP, Woo PCY, Yuen KY
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2011
Completion Date:08/2014


Project Title:Matrix-assisted laser desorption ionization time-of-flight mass spectrometry for identification of bacteria that are difficult to identify in clinical laboratories
Investigator(s):Lau SKP, Woo PCY, Teng LL
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:01/2013
Completion Date:12/2014


Project Title:Molecular diversity and evolution of bat group C betacoronaviruses: implications on the origin of the novel human group C betacoronavirus
Investigator(s):Lau SKP, Woo PCY, Zheng B
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:09/2013


Project Title:Molecular evolution and diversity of human coronavirus 229E associated with respiratory tract infections
Investigator(s):Lau SKP, Woo PCY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:01/2014


Project Title:Matrix-assisted laser desorption ionization time-of-flight mass spectrometry for rapid identification of Penicillium marneffei
Investigator(s):Lau SKP, Woo PCY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:01/2015


Project Title:The 15th International Symposium; Emerging coronaviruses: lesson from OC43, SARS to MERS
Investigator(s):Lau SKP
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2015


List of Research Outputs

Chan J.F.W., Lau S.K.P., Wong S.C.Y., To K.K.W., Cheng V.C.C. and Yuen K.Y., Comparative analysis of patients with chronic pulmonary aspergillosis and invasive pulmonary aspergillosis: a ten-year retrospective study, 25th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2015), European Society of Clinical Microbiology and Infectious Diseases, Copenhagen, Denmark. 2015.
Chan J.F.W., Lau S.K.P., To K.K.W., Cheng V.C.C., Woo P.C.Y. and Yuen K.Y., Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease, Clinical Microbiology Reviews. 2015, 28: 465-522.
Chen J.H.K., She K.K.K., Wong O.Y., Teng L.L., Yam W.C., Lau S.K.P., Woo P.C.Y., Cheng V.C.C. and Yuen K.Y., Use of MALDI Biotyper plus ClinProTools mass spectra analysis for correct identification of Streptococcus pneumoniae and Streptococcus mitis / oralis , Journal of Clinical Pathology. 2015, jclinpath-2014-202818.
Chen Y., Chan K.H., Kang Y., Chen H., Luk K.H., Poon R.W.S., Chan J.F.W., Yuen K.Y., Xia N., Lau S.K.P. and Woo P.C.Y., A sensitive and specific antigen detection assay for Middle East respiratory syndrome coronavirus, Emerging Microbes and Infections. 2015, 4: e26.
Lam J.Y., Wu A.K., Leung W.S., Cheung I., TSANG C.C., Chen J.H.K., Chan J.F.W., Tse C.W., Lee R.A., Lau S.K.P. and Woo P.C.Y., Gordonia species as emerging causes of continuous ambulatory peritoneal dialysis-related peritonitis identified by 16S rRNA and secA1 genes sequencing and MALDI-TOF MS, Journal of Clinical Microbiology. 2015, 53: 671-676.
Lau S.K.P., Chan S.Y., Curreem S.O.T., Hui S.W., Lau C.Y., Lee P., Ho C.C., Martelli P. and Woo P.C.Y., Burkholderia pseudomallei in soil samples from an oceanarium in Hong Kong detected using a sensitive PCR assay, Emerging Microbes and Infections. 2014, 3: e69.
Lau S.K.P., Woo P.C.Y., Yip C.Y., Li K.S.M., Fan Y.Y., BAI R., Huang Y., Chan K.H. and Yuen K.Y., Chickens host diverse picornaviruses originated from potential interspecies transmission with recombination, Journal of General Virology. 2014, 95: 1929-1944.
Lau S.K.P., Woo P.C.Y., Li K.S.M., Tsang K.L., Fan Y.Y., Luk K.H., Cai J., Chan K.H., Zheng B., Wang M. and Yuen K.Y., Discovery of a novel coronavirus, China Rattus coronavirus HKU24, from Norway rats supports murine origin of Betacoronavirus 1 with implications on the ancestor of Betacoronavirus lineage A, Journal of Virology. 2015, 89: 3076-3092.
Lau S.K.P., Teng L.L., Huang Y., Curreem S.O.T., Tsui S.K. and Woo P.C.Y., Draft Genome Sequence of Catabacter hongkongensis type strain HKU16T isolated from a patient with bacteremia and intestinal obstruction, Genome Announcements. 2015, 3: e00531-15.
Lau S.K.P., Wu A.K.L., Teng L.L., Tse H., Curreem S.O.T., Tsui S.K.W., Huang Y., Chen J.H.K., Lee R.A., Yuen K.Y. and Woo P.C.Y., Evidence for Elizabethkingia anophelis transmission from mother to infant, Hong Kong., Emerging Infectious Diseases. 2015, 21: 232-241.
Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Lau C.Y., Chow W.N., Ngan A.H., To K.K.W., Chan J.F.W., Hung I.F.N., Yam W.C., Yuen K.Y. and Woo P.C.Y., Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics: exploration of potential biomarkers, Emerging Microbes & Infections. 2015, 4: e6.
Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Lau C.Y., Chow W.N., Ngan A.H., To K.K.W., Chan J.F.W., Hung I.F.N., Yam W.C., Yuen K.Y. and Woo P.C.Y., Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics: exploration of potential biomarkers, Emerging Microbes and Infections. 2015, 4: e6.
Lau S.K.P., Sridhar S., Ho C.C., Chow W.N., Lee K.C., Lam C.W., Yuen K.Y. and Woo P.C.Y., Laboratory diagnosis of melioidosis: Past, present and future, Experimental Biology and Medicine. 2015, 240: 742-751.
Lee K.C., Tam W.T., Lo K.C., Tsang K.L., Lau C.Y., To K.K.W., Chan J.F.W., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Metabolomics Analysis Reveals Specific Novel Tetrapeptide and Potential Anti-Inflammatory Metabolites in Pathogenic Aspergillus species, International Journal of Molecular Sciences. 2015, 16: 13850-13867.
Sridhar S., To K.K.W., Chan J.F.W., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., A systematic approach to novel virus discovery in emerging infectious disease outbreaks, Journal of Molecular Diagnostics. 2015, 17: 230-241.
Sridhar S., Luk H.K., Lau S.K.P. and Woo P.C.Y., First report of severe parainfluenza virus 4B and rhinovirus C coinfection in a liver transplant recipient treated with immunoglobulin, Journal of Clinical Virology. 2014, 61: 611-614.
Sridhar S., Lau S.K.P. and Woo P.C.Y., Hepatitis E: a disease of reemerging importance, Journal of Formosan Medical Association. 2015, 114: 681-690.
TSANG C.C., Chan J.F.W., Trendell-Smith N.J., Ngan A.H., Ling I.W., Lau S.K.P. and Woo P.C.Y., Subcutaneous phaeohyphomycosis in a patient with IgG4-related sclerosing disease caused by a novel ascomycete, Hongkongmyces pedis gen. et sp. nov.: first report of human infection associated with the family Lindgomycetaceae, Medical Mycology. 2014, 52: 736-747.
Teng L.L., Huang Y., Tse H., Chen J.H.K., TANG Y., Lau S.K.P. and Woo P.C.Y., Phylogenomic and MALDI-TOF MS analysis of Streptococcus sinensis HKU4T reveals a distinct phylogenetic clade in the genus Streptococcus, Genome Biology and Evolution. 2014, 6: 2930-2943.
To K.K.W., Tse H., Chan W.M., CHOI K.Y., Zhang J., Sridhar S., Wong S.C.Y., Chan J.F.W., Chan S.F., Woo P.C.Y., Lau S.K.P., Lo J.Y., Chan K.H., Cheng V.C.C. and Yuen K.Y., A novel psittacine adenovirus identified during an outbreak of avian chlamydiosis and human psittacosis: zoonosis associated with virus-bacterium coinfection in birds, PLoS Neglected Tropical Diseases. 2014, 8: e3318.
To K.K.W., Lee K.C., Wong S.S.Y., Lo K.C., Lui Y.M., Akhee S.J., Wu L., Ke Y., Law C.Y., Sze K.H., Lau S.K.P., Woo P.C.Y., Lam C.W. and Yuen K.Y., Lipid mediators of inflammation as novel plasma biomarkers to identify patients with bacteremia, Journal of Infection. 2015, 70: 433-444.
Tsang C.L., Chan J.F.W., Ip P.C.P., Ngan A.H.Y., Chen J.H.K., Lau S.K.P. and Woo P.C.Y., Subcutaneous Phaeohyphomycotic Nodule Due to Phialemoniopsis hongkongensis sp. nov., In: Alexander J. McAdam, MD, Journal of Clinical Microbiology. American Society for Microbiology (ASM), 2014, 52: 3280-3289.
Wang Q., Lau S.K.P., Liu F., Zhao Y., Li H.M., Li B.X., Hu Y.L., Woo P.C.Y. and Liu C.H., Molecular epidemiology and clinical characteristics of drug-resistant Mycobacterium tuberculosis in a tuberculosis referral hospital in China, PLoS One. 2014, 9: e110209.
Woo P.C.Y., Lau S.K.P., Martelli P., Hui S.W., Lau C.Y., Fan Y.Y., Groff J.M., Tam W.T., Chan K.H. and Yuen K.Y., Fatal systemic necrotizing infections associated with a novel paramyxovirus, anaconda paramyxovirus, in green anaconda juveniles, Journal of Clinical Microbiology. 2014, 52: 3614-3623.
Woo P.C.Y., Lau S.K.P., Teng L.L., Tsang K.L., Joseph M., Wong Y.M., TANG Y., Sivakumar S., BAI R., Wernery R., Wernery U. and Yuen K.Y., Metagenomic analysis of viromes of dromedary camel fecal samples reveals large number and high diversity of circoviruses and picobirnaviruses, Virology. 2014, 471-473: 117-125.
Woo P.C.Y., Wu A.K., TSANG C.C., Leung K.W., Ngan A.H., Curreem S.O.T., Lam K.W., Chen J.H.K., Chan J.F.W. and Lau S.K.P., Streptobacillus hongkongensis sp. nov., isolated from patients with quinsy and septic arthritis in Hong Kong and emended descriptions of the genus Streptobacillus and the species Streptobacillus moniliformis, International Journal of Systematic and Evolutionary Microbiology. 2014, 64: 3034-3039.
Woo P.C.Y., Lam C.W., Tam W.T., Lee K.C., Yung K.Y., Leung K.F., Sze K.H., Lau S.K.P. and Yuen K.Y., The biosynthetic pathway for a thousand-year-old natural food colorant and citrinin in Penicillium marneffei, Scientific Reports. 2014, 4: 6728.
Xiong L., Teng L.L., Watt R.M., Liu C., Lau S.K.P. and Woo P.C.Y., Molecular characterization of arginine deiminase pathway in Laribacter hongkongensis and unique regulation of arginine catabolism and anabolism by multiple environmental stresses, Environmental Microbiology. 2015.
Xiong L., Teng L.L., Lau S.K.P. and Woo P.C.Y., Molecular characterization of the arginine deiminase pathways in Laribacter hongkongensis: unique genetic organisation and regulation by transcriptional regulator ArgR and multiple environmental stresses, Microbial Stress Response Molecular Systems and Community Responses (Gordon Research Conferences), 2014 (South Hadley, MA, USA). 2014.
Yang E., Chow W.N., Wang G., Woo P.C.Y., Lau S.K.P., Yuen K.Y., Lin X. and Cai J.J., Signature gene expression reveals novel clues to the molecular mechanisms of dimorphic transition in Penicillium marneffei, PLoS Genetics. 2014, 10: e1004662.
Yip C.Y., Lo K.L., Que T.L., Lee R.A., Chan K.H., Yuen K.Y., Woo P.C.Y. and Lau S.K.P., Epidemiology of human parechovirus, Aichi virus and salivirus in fecal samples from hospitalized children with gastroenteritis in Hong Kong, Virology Journal. 2014, 11: 182.


Researcher : Lau SY

List of Research Outputs

Song W., Wang P., Mok B.W.Y., Lau S.Y., HUANG X., Wu W.L., ZHENG M., WEN X., Yang S., Chen Y., Li L., Yuen K.Y. and Chen H., The K526R substitution in viral protein ​PB2 enhances the effects of E627K on influenza virus replication, Nature Communications. 2014.
To K.K.W., Song W., Lau S.Y., Que T.L., Lung D.C., Hung I.F.N., Chen H. and Yuen K.Y., Unique reassortant of influenza A(H7N9) virus associated with severe disease emerging in Hong Kong, Journal of Infection. 2014, 69(1): 60-68.


Researcher : Lee CY

List of Research Outputs

Li C., Li C., Zhang J., To K.K.W., Lee C.Y., Zhu H., Wu W.L., Chan J.F.W., Chen H., Hung I.F.N., Li L. and Yuen K.Y., Avian Influenza A H7N9 Virus Induces Severe Pneumonia in Mice without Prior Adaptation and Responds to a Combination of Zanamivir and COX-2 Inhibitor , PLoS One. 2014, 9(9): e107966.


Researcher : Lee KC

List of Research Outputs

Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Lau C.Y., Chow W.N., Ngan A.H., To K.K.W., Chan J.F.W., Hung I.F.N., Yam W.C., Yuen K.Y. and Woo P.C.Y., Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics: exploration of potential biomarkers, Emerging Microbes & Infections. 2015, 4: e6.
Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Lau C.Y., Chow W.N., Ngan A.H., To K.K.W., Chan J.F.W., Hung I.F.N., Yam W.C., Yuen K.Y. and Woo P.C.Y., Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics: exploration of potential biomarkers, Emerging Microbes and Infections. 2015, 4: e6.
Lau S.K.P., Sridhar S., Ho C.C., Chow W.N., Lee K.C., Lam C.W., Yuen K.Y. and Woo P.C.Y., Laboratory diagnosis of melioidosis: Past, present and future, Experimental Biology and Medicine. 2015, 240: 742-751.
Lee K.C., Tam W.T., Lo K.C., Tsang K.L., Lau C.Y., To K.K.W., Chan J.F.W., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Metabolomics Analysis Reveals Specific Novel Tetrapeptide and Potential Anti-Inflammatory Metabolites in Pathogenic Aspergillus species, International Journal of Molecular Sciences. 2015, 16: 13850-13867.
To K.K.W., Lee K.C., Wong S.S.Y., Lo K.C., Lui Y.M., Akhee S.J., Wu L., Ke Y., Law C.Y., Sze K.H., Lau S.K.P., Woo P.C.Y., Lam C.W. and Yuen K.Y., Lipid mediators of inflammation as novel plasma biomarkers to identify patients with bacteremia, Journal of Infection. 2015, 70: 433-444.


Researcher : Lee MY

Project Title:Direct identification and quantification of host and viral microRNAs after influenza infection using the next generation ultra-high throughput DNA sequencer
Investigator(s):Lee MY, Lok S, Cheung CY
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:05/2009


Project Title:Determining the ligand and function of TLR10: a novel innate immune sensor in viral infection
Investigator(s):Lee MY, Jin D, Peiris JSM
Department:School of Public Health
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2014




Researcher : Li C

List of Research Outputs

CHENG Z., Zhou J., To K.K.W., Chu H., Li C., Song Y., Zheng B. and Yuen K.Y., Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza., Journal of Infectious Diseases. 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Best Abstract in Clinical Medicine (Oral) - "Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial", 20th Medical Research Conference 2015, Department of Medicine, The University of Hong Kong . 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial, 20th Medical Research Conference, The University of Hong Kong, 17 Jan 2015. (Oral presentation - Best abstract in Clinical Medicine) . 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial, Clinical Infectious Diseases . 2014, 59(9): 1246-55.
Li C., Li C., Zhang J., To K.K.W., Lee C.Y., Zhu H., Wu W.L., Chan J.F.W., Chen H., Hung I.F.N., Li L. and Yuen K.Y., Avian Influenza A H7N9 Virus Induces Severe Pneumonia in Mice without Prior Adaptation and Responds to a Combination of Zanamivir and COX-2 Inhibitor , PLoS One. 2014, 9(9): e107966.
To K.K.W., Zhang J., Chan S.F., LI C., Cai J., Lau C.Y., Li C., Akhee S.J., Wu W.L., Li L., Tsang K.L., Chan K.H., Chen H. and Yuen K.Y., Recombinant influenza A virus hemagglutinin HA2 subunit protects mice against influenza A(H7N9) virus infection, Archives of Virology. 2015, 160: 777-786.


Researcher : Li C

List of Research Outputs

CHENG Z., Zhou J., To K.K.W., Chu H., Li C., Song Y., Zheng B. and Yuen K.Y., Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza., Journal of Infectious Diseases. 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Best Abstract in Clinical Medicine (Oral) - "Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial", 20th Medical Research Conference 2015, Department of Medicine, The University of Hong Kong . 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial, 20th Medical Research Conference, The University of Hong Kong, 17 Jan 2015. (Oral presentation - Best abstract in Clinical Medicine) . 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial, Clinical Infectious Diseases . 2014, 59(9): 1246-55.
Li C., Li C., Zhang J., To K.K.W., Lee C.Y., Zhu H., Wu W.L., Chan J.F.W., Chen H., Hung I.F.N., Li L. and Yuen K.Y., Avian Influenza A H7N9 Virus Induces Severe Pneumonia in Mice without Prior Adaptation and Responds to a Combination of Zanamivir and COX-2 Inhibitor , PLoS One. 2014, 9(9): e107966.
To K.K.W., Zhang J., Chan S.F., LI C., Cai J., Lau C.Y., Li C., Akhee S.J., Wu W.L., Li L., Tsang K.L., Chan K.H., Chen H. and Yuen K.Y., Recombinant influenza A virus hemagglutinin HA2 subunit protects mice against influenza A(H7N9) virus infection, Archives of Virology. 2015, 160: 777-786.


Researcher : Li C

List of Research Outputs

CHENG Z., Zhou J., To K.K.W., Chu H., Li C., Song Y., Zheng B. and Yuen K.Y., Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza., Journal of Infectious Diseases. 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Best Abstract in Clinical Medicine (Oral) - "Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial", 20th Medical Research Conference 2015, Department of Medicine, The University of Hong Kong . 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial, 20th Medical Research Conference, The University of Hong Kong, 17 Jan 2015. (Oral presentation - Best abstract in Clinical Medicine) . 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial, Clinical Infectious Diseases . 2014, 59(9): 1246-55.
Li C., Li C., Zhang J., To K.K.W., Lee C.Y., Zhu H., Wu W.L., Chan J.F.W., Chen H., Hung I.F.N., Li L. and Yuen K.Y., Avian Influenza A H7N9 Virus Induces Severe Pneumonia in Mice without Prior Adaptation and Responds to a Combination of Zanamivir and COX-2 Inhibitor , PLoS One. 2014, 9(9): e107966.
To K.K.W., Zhang J., Chan S.F., LI C., Cai J., Lau C.Y., Li C., Akhee S.J., Wu W.L., Li L., Tsang K.L., Chan K.H., Chen H. and Yuen K.Y., Recombinant influenza A virus hemagglutinin HA2 subunit protects mice against influenza A(H7N9) virus infection, Archives of Virology. 2015, 160: 777-786.


Researcher : Li KSM

List of Research Outputs

Lau S.K.P., Woo P.C.Y., Yip C.Y., Li K.S.M., Fan Y.Y., BAI R., Huang Y., Chan K.H. and Yuen K.Y., Chickens host diverse picornaviruses originated from potential interspecies transmission with recombination, Journal of General Virology. 2014, 95: 1929-1944.
Lau S.K.P., Woo P.C.Y., Li K.S.M., Tsang K.L., Fan Y.Y., Luk K.H., Cai J., Chan K.H., Zheng B., Wang M. and Yuen K.Y., Discovery of a novel coronavirus, China Rattus coronavirus HKU24, from Norway rats supports murine origin of Betacoronavirus 1 with implications on the ancestor of Betacoronavirus lineage A, Journal of Virology. 2015, 89: 3076-3092.


Researcher : Li PCK

List of Research Outputs

Jiamsakul A., Sirivichayakul S., Ditangco R., Wong K.H., Li P.C.K., Praparattanapan J., Phanuphak P., Segubre-Mercado E., Yam W.C., Sirisanthana T., Singtoroj T. and Law M., Transmitted drug resistance in recently infected HIV-positive Individuals from four urban locations across Asia (2007–2010) – TASER-S, AIDS Research and Therapy. 2015, 12: 3.


Researcher : Li PY

List of Research Outputs

Chan T.C.I., Hung I.F.N., Chan K.H., Li P.Y., Li T.W., Luk J.K.H., Chu L.W. and Chan H.W.F., A Randomized Controlled Trial to Compare Immunogenicity Between Intramuscular and Intradermal Trivalent Influenza Vaccination in Nursing Home Older Adults, 20th Medical Research Conference, The University of Hong Kong, 17 Jan 2015.. 2015.
Chan T.C.I., Hung I.F.N., Chan K.H., Li P.Y., Li T.W., Luk J.K.H., Chu L.W. and Chan H.W.F., Local Adverse Effect of Intradermal and Administration of Influenza Vaccination is an Indicator of Satisfactory Immunogenicity, 20th Medical Research Conference 2015, The University of Hong Kong, 17 Jan 2015. . 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Best Abstract in Clinical Medicine (Oral) - "Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial", 20th Medical Research Conference 2015, Department of Medicine, The University of Hong Kong . 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial, 20th Medical Research Conference, The University of Hong Kong, 17 Jan 2015. (Oral presentation - Best abstract in Clinical Medicine) . 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial, Clinical Infectious Diseases . 2014, 59(9): 1246-55.


Researcher : Li TW

List of Research Outputs

Chan T.C.I., Hung I.F.N., Chan K.H., Li P.Y., Li T.W., Luk J.K.H., Chu L.W. and Chan H.W.F., A Randomized Controlled Trial to Compare Immunogenicity Between Intramuscular and Intradermal Trivalent Influenza Vaccination in Nursing Home Older Adults, 20th Medical Research Conference, The University of Hong Kong, 17 Jan 2015.. 2015.
Chan T.C.I., Hung I.F.N., Chan K.H., Li P.Y., Li T.W., Luk J.K.H., Chu L.W. and Chan H.W.F., Local Adverse Effect of Intradermal and Administration of Influenza Vaccination is an Indicator of Satisfactory Immunogenicity, 20th Medical Research Conference 2015, The University of Hong Kong, 17 Jan 2015. . 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Best Abstract in Clinical Medicine (Oral) - "Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial", 20th Medical Research Conference 2015, Department of Medicine, The University of Hong Kong . 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial, 20th Medical Research Conference, The University of Hong Kong, 17 Jan 2015. (Oral presentation - Best abstract in Clinical Medicine) . 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial, Clinical Infectious Diseases . 2014, 59(9): 1246-55.


Researcher : Liang J

List of Research Outputs

LIANG J., Liu L., Chen M.A.N.D.Y., Li M.A.N.-.P.O., Li C.H.U.N.-.H.O., Chan C.H.U.N.-.C.H.U.N.G., TANG X., PENG J., Cheung K.W., Yam W.C. and Chen Z., Community-based HIV-1 Early Diagnosis and Risk Behavior Analysis of Men Having Sex with Men in Hong Kong, PLOS one. 2015, Apr 27;10: 4.
Tan Z., ZHOU J., Cheung K.L.A., Yu Z., Cheung K.W., Liang J., Wang H., LEE B.K., Man K., Liu L., Yuen K.Y. and Chen Z., Vaccine-Elicited CD8+ T Cells Cure Mesothelioma by Overcoming Tumor-Induced Immunosuppressive Environment, Cancer Research. 2014, 74: 6010-6021.


Researcher : Liu C

List of Research Outputs

Ho P.L., Liu C., Lo W.U., Lai E.L.Y., Lau T.C., Law O.K. and Chow K.H., Prevalence and characterization of hybrid blaCTX-M among Escherichia coli isolates from livestock and other animals, Diagnostic Microbiology and Infectious Disease. 2015, 82: 148-153.


Researcher : Liu L

Project Title:Early HIV-1 diagnosis using in-house real-time PCR amplification on dried blood spots for men who have sex with men in Hong Kong
Investigator(s):Liu L
Department:LKS Medical Faculty
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:09/2009


Project Title:Identification of small molecule HIV-1 inhibitors with distinct new targets
Investigator(s):Liu L
Department:LKS Medical Faculty
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:02/2012


Project Title:The role of HIV-1/SIV Nef in immune activation through regulating the expression of PD-1 and delta-PD-1
Investigator(s):Liu L, Chen Z
Department:LKS Medical Faculty
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:03/2012


Project Title:Molecular mechanisms of Nef mediated regulation of PD-1 expression during HIV/SIV infection
Investigator(s):Liu L, Chen Z
Department:LKS Medical Faculty
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:02/2014


Project Title:A novel small molecule from natural product as a potential agent for purging HIV-1 from the latent reservoir
Investigator(s):Liu L
Department:LKS Medical Faculty
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2014


Project Title:AIDS 2014; Community-based HIV-1 Early Diagnosis and Risk Behavior Analysis of Men Having Sex with Men in Hong Kong
Investigator(s):Liu L
Department:LKS Medical Faculty
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:07/2014
Completion Date:07/2014


Project Title:Defining the role of monocyte-derived dendritic cells in potentiating durable and protective T-cell immunity by a newly identified PD-1 isoform
Investigator(s):Liu L, Chen Z
Department:LKS Medical Faculty
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2015


List of Research Outputs

Cheng L., Tang X., Liu L., PENG J., Nishiura K., Cheung K.L.A., GUO J., WU X., Tang H., An M., ZHOU J., Cheung K.W., Wang H., Guan X., Wu Z. and Chen Z., Monoclonal antibodies specific to human Δ42PD1: A novel immunoregulator potentially involved in HIV-1 and tumor pathogenesis, mAbs. 2015, 7: 620-629.
LIANG J., Liu L., Chen M.A.N.D.Y., Li M.A.N.-.P.O., Li C.H.U.N.-.H.O., Chan C.H.U.N.-.C.H.U.N.G., TANG X., PENG J., Cheung K.W., Yam W.C. and Chen Z., Community-based HIV-1 Early Diagnosis and Risk Behavior Analysis of Men Having Sex with Men in Hong Kong, PLOS one. 2015, Apr 27;10: 4.
Liu L., Chen J. and Chen Z., Patent No: 61/917,175.Title: Use of Isoflavones for the Treatment of Retroviral Infection, US patent. 2015.
Tan Z., ZHOU J., Cheung K.L.A., Yu Z., Cheung K.W., Liang J., Wang H., LEE B.K., Man K., Liu L., Yuen K.Y. and Chen Z., Vaccine-Elicited CD8+ T Cells Cure Mesothelioma by Overcoming Tumor-Induced Immunosuppressive Environment, Cancer Research. 2014, 74: 6010-6021.
Zhang Y.I.N.F.E.N.G., Li S.I.A.-.K.A.M., Yang Y.I., Liu M.I.N.G.H.U.A., Lee N.E.I.S.O.N., Tang X.I.A.N., Wang H., Liu L., Chen Z., Zhang C., Wang J. and Tsui K.Y., Whole genome methylation array reveals the down-regulation of IGFBP6 and SATB2 by HIV-1, Scientific Reports. 2015, 5: 10806.


Researcher : Lo KC

List of Research Outputs

Lee K.C., Tam W.T., Lo K.C., Tsang K.L., Lau C.Y., To K.K.W., Chan J.F.W., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Metabolomics Analysis Reveals Specific Novel Tetrapeptide and Potential Anti-Inflammatory Metabolites in Pathogenic Aspergillus species, International Journal of Molecular Sciences. 2015, 16: 13850-13867.
To K.K.W., Lee K.C., Wong S.S.Y., Lo K.C., Lui Y.M., Akhee S.J., Wu L., Ke Y., Law C.Y., Sze K.H., Lau S.K.P., Woo P.C.Y., Lam C.W. and Yuen K.Y., Lipid mediators of inflammation as novel plasma biomarkers to identify patients with bacteremia, Journal of Infection. 2015, 70: 433-444.


Researcher : Lo WU

Project Title:54th Interscience Conference on Antimicrobial Agents and Chemotherapy; International Dissemination of an IncX3 Plasmid Carrying blaNDM among Enterobacteriaceae/Emergence of a New Sequence Type Vancomycin-Resistant Enterococcus faecium in Hong Kong
Investigator(s):Lo WU
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:09/2014
Completion Date:09/2014


Project Title:Prevalence and Molecular Characterisation of Novel Chimeric β-lactamases in Escherichia coli from Human and Animals
Investigator(s):Lo WU, Ho PL
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:01/2015


List of Research Outputs

Ho P.L., Lo W.U., Lai E.L.Y., LAW Y.T., LEUNG M.H., WANG Y. and Chow K.H., Clonal diversity of CTX-M-producing, multidrug-resistant Escherichia coli from rodents, Journal of Medical Microbiology. 2015, 64: 185-190.
Ho P.L., Chu Y.P., Lo W.U., Chow K.H., LAW Y.T., Tse C.W., Ng T.K., Cheng V.C.C. and Que T.L., High prevalence of Escherichia coli sequence type 131 among antimicrobial-resistant E. coli isolates from geriatric patients, Journal of Medical Microbiology. 2015, 64: 243-247.
Ho P.L., Liu C., Lo W.U., Lai E.L.Y., Lau T.C., Law O.K. and Chow K.H., Prevalence and characterization of hybrid blaCTX-M among Escherichia coli isolates from livestock and other animals, Diagnostic Microbiology and Infectious Disease. 2015, 82: 148-153.
Ho P.L., Leung L.M., Chow K.H., Lai E.L.Y., Lo W.U. and Ng T.K., Prevalence of aminoglycoside modifying enzyme and 16S ribosomal RNA methylase genes among aminoglycoside-resistant Escherichia coli isolates, Journal of Microbiology, Immunology and Infection. 2014.
WANG Y..., Lo W.U., Lai E.L.Y., Chow K.H. and Ho P.L., Complete sequence of a multidrug-resistant IncL/M plasmid pIMP-HB623 co-carrying blaIMP-34 and fosC2 in an Enterobacter cloacae associated with medical travel to China., Antimicrob Agents Chemother. the United States, 2015, pii: AAC.00375-15.


Researcher : Lui YM

List of Research Outputs

To K.K.W., Lee K.C., Wong S.S.Y., Lo K.C., Lui Y.M., Akhee S.J., Wu L., Ke Y., Law C.Y., Sze K.H., Lau S.K.P., Woo P.C.Y., Lam C.W. and Yuen K.Y., Lipid mediators of inflammation as novel plasma biomarkers to identify patients with bacteremia, Journal of Infection. 2015, 70: 433-444.


Researcher : Luk KH

List of Research Outputs

Chen Y., Chan K.H., Kang Y., Chen H., Luk K.H., Poon R.W.S., Chan J.F.W., Yuen K.Y., Xia N., Lau S.K.P. and Woo P.C.Y., A sensitive and specific antigen detection assay for Middle East respiratory syndrome coronavirus, Emerging Microbes and Infections. 2015, 4: e26.
Lau S.K.P., Woo P.C.Y., Li K.S.M., Tsang K.L., Fan Y.Y., Luk K.H., Cai J., Chan K.H., Zheng B., Wang M. and Yuen K.Y., Discovery of a novel coronavirus, China Rattus coronavirus HKU24, from Norway rats supports murine origin of Betacoronavirus 1 with implications on the ancestor of Betacoronavirus lineage A, Journal of Virology. 2015, 89: 3076-3092.


Researcher : Mok BWY

Project Title:The role of influenza virus NS1 in miR-146a-mediated regulation of the innate immune response
Investigator(s):Mok BWY, Chen H
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:06/2014


Project Title:Human RNA viruses ; Nuclear Dicer mediates IFN-β production in response to RNA virus infection
Investigator(s):Mok BWY
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2014
Completion Date:10/2014


List of Research Outputs

Mok B.W.Y., Nuclear Dicer mediates IFN-b production in response to RNA virus infection , EMBO Workshop on Human RNA viruses jointly sponsored by the ICGEB. 2014.
Song W., Wang P., Mok B.W.Y., Lau S.Y., HUANG X., Wu W.L., ZHENG M., WEN X., Yang S., Chen Y., Li L., Yuen K.Y. and Chen H., The K526R substitution in viral protein ​PB2 enhances the effects of E627K on influenza virus replication, Nature Communications. 2014.


Researcher : Ng F

List of Research Outputs

LEUNG H.C., Chan C.S., Poon K.M., ZHAO H., Cheung C.Y., Ng F., Huang J. and Zheng B., An H5N1-based matrix protein 2 ectodomain tetrameric peptide vaccine provides cross-protection against lethal infection with H7N9 influenza virus, Emerging Microbes & Infections. 2015, 4: e22.
Tong M., Fung T.M., Luk T.C.S., Ng K.Y., Lee K.W., Lin C., Yam J.W.P., Chan K.W., Ng F., Zheng B., Yuan Y.F., Xie D., Lo C.M., Man K., Guan X. and Ma S.K.Y., ANXA3/JNK Signaling Promotes Self-Renewal and Tumor Growth, and Its Blockade Provides a Therapeutic Target for Hepatocellular Carcinoma, Stem Cell Reports. 2015.


Researcher : Ng HM

List of Research Outputs

To W.C.S., Chen J.H.K., Wong K.H., Chan K.C.W., Ng H.M. and Yam W.C., Molecular epidemiology and phylogenetic analysis of minor HIV-1 subtypes in Hong Kong: Emergence and spread of CRF07_BC and subtype C, 25th European Congress of Clinical Microbiology and Infectious Diseases. 2015.


Researcher : Ng IHY

List of Research Outputs

Cheung P.P.H., Rogozin I.B., Choy K.T., Ng I.H.Y., Peiris J.S.M. and Yen H., Comparative mutational analyses of influenza A viruses, RNA. 2015, 21(1): 36-47.


Researcher : Ng SP

Project Title:Collection of background information on the alternative faecal indicators in the environmental waters of Hong Kong and their correlation with Escherichia coli
Investigator(s):Ng SP, Yam WC
Department:Microbiology
Source(s) of Funding:Environment Protection Department - General Award
Start Date:06/2001




Researcher : Nishiura K

List of Research Outputs

Cheng L., Tang X., Liu L., PENG J., Nishiura K., Cheung K.L.A., GUO J., WU X., Tang H., An M., ZHOU J., Cheung K.W., Wang H., Guan X., Wu Z. and Chen Z., Monoclonal antibodies specific to human Δ42PD1: A novel immunoregulator potentially involved in HIV-1 and tumor pathogenesis, mAbs. 2015, 7: 620-629.


Researcher : PENG J

List of Research Outputs

Cheng L., Tang X., Liu L., PENG J., Nishiura K., Cheung K.L.A., GUO J., WU X., Tang H., An M., ZHOU J., Cheung K.W., Wang H., Guan X., Wu Z. and Chen Z., Monoclonal antibodies specific to human Δ42PD1: A novel immunoregulator potentially involved in HIV-1 and tumor pathogenesis, mAbs. 2015, 7: 620-629.
LIANG J., Liu L., Chen M.A.N.D.Y., Li M.A.N.-.P.O., Li C.H.U.N.-.H.O., Chan C.H.U.N.-.C.H.U.N.G., TANG X., PENG J., Cheung K.W., Yam W.C. and Chen Z., Community-based HIV-1 Early Diagnosis and Risk Behavior Analysis of Men Having Sex with Men in Hong Kong, PLOS one. 2015, Apr 27;10: 4.


Researcher : Peiris JSM

Project Title:IV International Symposium on Respiratory Viral Infections The Influenza Disease Burden in Hong Kong: the Rates of Hospitalisation in Children
Investigator(s):Peiris JSM
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:11/2001


Project Title:Influenza pandemic preparedness in Asia (Research collaboration with national Institute of Allergy and Infectious Diseases (NIAID), St. Jude Children's Research Hospital, Inc. (SJCRH) and The University of Hong Kong)
Investigator(s):Peiris JSM, Guan Y
Department:Microbiology
Source(s) of Funding:National Institutes of Health, US Department of Health and Human Services - General Award
Start Date:04/2003


Project Title:Virus-cell interaction and the pathogenesis of SARS
Investigator(s):Peiris JSM
Department:Microbiology
Source(s) of Funding:VCO SARS Research Fund
Start Date:07/2003


Project Title:Viral determinants underlying the increased secretion of pro-inflammatory cytokines in H5N1 infected human macrophages: a mechanism for the unusual severity of human H5N1 disease?
Investigator(s):Peiris JSM, Guan Y, Lau ASY, Poon LLM
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2003


Project Title:The macrophage in the pathogenesis of Severe Acute Respiratory Syndrome Coronavirus infection
Investigator(s):Peiris JSM
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:12/2005


Project Title:The pathogenesis of avian influenza A H5N1 in humans: macrophage and epithelial cell-virus interactions in vitro and ex-vivo
Investigator(s):Peiris JSM
Department:Microbiology
Source(s) of Funding:The Wellcome Trust - General Award
Start Date:01/2007


Project Title:Communicable Diseases Surveillance and Response (CSR) - Standardization and shipment of PCR diagnostic kit for Avian Influenza detection to Member countries (viz: Bangladesh, Indonesia, Myanmar, Sri Lanka and Thailand)
Investigator(s):Peiris JSM
Department:Microbiology
Source(s) of Funding:Collaborating Project Fund
Start Date:06/2007


Project Title:Control of Pandemic and Inter-pandemic Influenza
Investigator(s):Peiris JSM, Guan Y, Yuen KY, Chen H, Leung GM, Lau YL
Department:Microbiology
Source(s) of Funding:Areas of Excellence Scheme
Start Date:01/2008


Project Title:Host responses that correlate with respiratory droplet transmission of swine-origin influenza viruses in ferrets
Investigator(s):Peiris JSM, Yen H, Nicholls JM
Department:School of Public Health
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:10/2013


Project Title:Risk assessing human transmission potential of H7N9 viruses using ex vivo cultures of the human respiratory tract
Investigator(s):Peiris JSM, Nicholls JM, Chan MCW, Chan WY, Lai JCC, Mok KP
Department:School of Public Health
Source(s) of Funding:Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential
Start Date:05/2014


Project Title:Surveillance of influenza A including subtype H7N9 in outpatients with influenza-like illness and hospitalized patients with severe acute respiratory illness (SARI) presenting at The First Affiliated Hospital of Guangzhou Medical University
Investigator(s):Peiris JSM, Mok KP, Cowling BJ
Department:School of Public Health
Source(s) of Funding:Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential
Start Date:05/2014


Project Title:Viral, Host and Environmental Determinants of Influenza Virus Transmission and Pathogenesis
Investigator(s):Peiris JSM, Cowling BJ, Guan Y, Li Y, Nicholls JM, Poon LLM, Tu W, Yen H, Zhu H, Chan MCW, Lam TY, Jin D, Lee MY, Sanyal S, Mok KP, Sham PC
Department:School of Public Health
Source(s) of Funding:Theme-based Research Scheme
Start Date:01/2015


Project Title:Public Health Responses to threats of emerging, epidemic and endemic infectious diseases
Investigator(s):Peiris JSM, Cowling BJ, Wu JTK, Guan Y
Department:School of Public Health
Source(s) of Funding:Commissioned Research on Control of Infectious Diseases (Phase III)
Start Date:01/2015


Project Title:Role of influenza virus surface glycoproteins in virus-induced cell stress and inflammation
Investigator(s):Peiris JSM, Yen H
Department:School of Public Health
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:03/2015




Researcher : Poon KM

List of Research Outputs

LEUNG H.C., Chan C.S., Poon K.M., ZHAO H., Cheung C.Y., Ng F., Huang J. and Zheng B., An H5N1-based matrix protein 2 ectodomain tetrameric peptide vaccine provides cross-protection against lethal infection with H7N9 influenza virus, Emerging Microbes & Infections. 2015, 4: e22.


Researcher : Poon LLM

Project Title:Reverse genetic for a coronavirus responsible for severe acute respiratory syndrome
Investigator(s):Poon LLM, Guan Y
Department:Microbiology
Source(s) of Funding:VCO SARS Research Fund
Start Date:07/2003


Project Title:International Conference on Options for Control of Influenza V Genetic Characterization of a Novel Coronavirus Responsible for Severe Acute Respiratory Syndrome A Coronavirus Responsible for Severe Acute Respiratory Syndrome
Investigator(s):Poon LLM
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2003


Project Title:Centre for Research into Circulating Fetal Nucleic Acids
Investigator(s):Poon LLM
Department:Microbiology
Source(s) of Funding:Areas of Excellence Scheme
Start Date:01/2008


Project Title:Generation of live attenuated influenza viruses of vaccine potential by using codon usage bias
Investigator(s):Poon LLM
Department:School of Public Health
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:02/2013


Project Title:Characterization of fibronectin-mediated influenza A virus infection in human cells.
Investigator(s):Poon LLM, Chan WY
Department:School of Public Health
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2014




Researcher : Poon WSR

List of Research Outputs

Cheng V.C.C., Chen J.H.K., Tai J.W.M., Wong S.C.Y., Poon W.S.R., Hung I.F.N., Chan J.F.W., Ho P.L., Lo C.M. and Yuen K.Y., Decolonization of gastrointestinal carriage of vancomycin-resistant Enterococcus faecium: case series and review of literature, BMC Infectious Diseases. 2014, 14: 514.
Cheng V.C.C., Tai J.W., Lee W.M., Chan W.M., Wong S.C.Y., Chen J.H.K., Poon W.S.R., To K.K.W., Chan J.F.W., Ho P.L., Chan K.H. and Yuen K.Y., Infection Control Preparedness for Human Infection With Influenza A H7N9 in Hong Kong, Infection Control & Hospital Epidemiology. 2015, 36: 87-92.


Researcher : She KKK

List of Research Outputs

Chen J.H.K., She K.K.K., Wong O.Y., Teng L.L., Yam W.C., Lau S.K.P., Woo P.C.Y., Cheng V.C.C. and Yuen K.Y., Use of MALDI Biotyper plus ClinProTools mass spectra analysis for correct identification of Streptococcus pneumoniae and Streptococcus mitis / oralis , Journal of Clinical Pathology. 2015, jclinpath-2014-202818.


Researcher : Siu GKH

List of Research Outputs

Luo Y., Siu G.K.H., Yeung A.S.F., Chen J.H.K., Ho P.L., Leung K.W., Tsang L.Y., Cheng V.C.C., Guo L., Yang J., Ye L. and Yam W.C., Performance of the VITEK MS matrix-assisted laser desorption ionization-time of flight mass spectrometry system for rapid bacterial identification in two diagnostic centres in China, Journal of Medical Microbiology. 2015, 64: 18-24.
Siu G.K.H., Yam W.C., Zhang Y. and Kao R.Y.T., An Upstream Truncation of the furA-katG Operon Confers High-Level Isoniazid Resistance in a Mycobacterium tuberculosis Clinical Isolate with No Known Resistance-Associated Mutations, Antimicrobial Agents and Chemotherapy. 2014, 58: 6093-6100.


Researcher : Smith GJ

Project Title:Research into the ecology, evolution and population genetics of influenza A (H5N1) virus
Investigator(s):Smith GJ
Department:Microbiology
Source(s) of Funding:National Institutes of Health, US Department of Health and Human Services - General Award
Start Date:05/2007


Project Title:Outstanding Young Researcher Award 2008-2009
Investigator(s):Smith GJ
Department:Microbiology
Source(s) of Funding:Outstanding Young Researcher Award
Start Date:12/2009




Researcher : Song W

List of Research Outputs

Song W., Wang P., Mok B.W.Y., Lau S.Y., HUANG X., Wu W.L., ZHENG M., WEN X., Yang S., Chen Y., Li L., Yuen K.Y. and Chen H., The K526R substitution in viral protein ​PB2 enhances the effects of E627K on influenza virus replication, Nature Communications. 2014.
To K.K.W., Song W., Lau S.Y., Que T.L., Lung D.C., Hung I.F.N., Chen H. and Yuen K.Y., Unique reassortant of influenza A(H7N9) virus associated with severe disease emerging in Hong Kong, Journal of Infection. 2014, 69(1): 60-68.


Researcher : Sridhar S

List of Research Outputs

Lau S.K.P., Sridhar S., Ho C.C., Chow W.N., Lee K.C., Lam C.W., Yuen K.Y. and Woo P.C.Y., Laboratory diagnosis of melioidosis: Past, present and future, Experimental Biology and Medicine. 2015, 240: 742-751.
Sridhar S., To K.K.W., Chan J.F.W., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., A systematic approach to novel virus discovery in emerging infectious disease outbreaks, Journal of Molecular Diagnostics. 2015, 17: 230-241.
Sridhar S., Chan J.F.W. and Yuen K.Y., Fatal anti-aquaporin-4 seropositive neuromyelitis optica spectrum disorder in tuberculosis, BMC Infectious Diseases. 2014, 14: 470.
Sridhar S., Luk H.K., Lau S.K.P. and Woo P.C.Y., First report of severe parainfluenza virus 4B and rhinovirus C coinfection in a liver transplant recipient treated with immunoglobulin, Journal of Clinical Virology. 2014, 61: 611-614.
Sridhar S., Lau S.K.P. and Woo P.C.Y., Hepatitis E: a disease of reemerging importance, Journal of Formosan Medical Association. 2015, 114: 681-690.
To K.K.W., Tse H., Chan W.M., CHOI K.Y., Zhang J., Sridhar S., Wong S.C.Y., Chan J.F.W., Chan S.F., Woo P.C.Y., Lau S.K.P., Lo J.Y., Chan K.H., Cheng V.C.C. and Yuen K.Y., A novel psittacine adenovirus identified during an outbreak of avian chlamydiosis and human psittacosis: zoonosis associated with virus-bacterium coinfection in birds, PLoS Neglected Tropical Diseases. 2014, 8: e3318.


Researcher : Sze KH

Project Title:XXIInd International Conference on Magnetic Resonance in Biological Systems (ICMRBS 2006) Backbone Dynamics and Solution Structure of a Thermophilic Acylphosphatase from Pyrococcus Horikoshii by NMR Spectroscopy
Investigator(s):Sze KH
Department:Chemistry
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:08/2006


Project Title:Investigation of the binding of cell wall proteins of Penicillium marneffei and Aspergillus fumigates with proinflammatory lipid signaling molecules: A mechanism of pathogens evasion of host defense?
Investigator(s):Sze KH, Kao RYT, Woo PCY, Yuen KY
Department:Microbiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:11/2012


Project Title:Structure-function study of virulence factor Macrophage Infectivity Potentiator of Coxiella burnetii and Legionella pneumophila
Investigator(s):Sze KH, Yuen KY, Kao RYT
Department:Microbiology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2013


Project Title:Host target identification and characterization for the secreted virulence factors ESAT6/CFP10 of Mycobacterium tuberculosis and structure-based screening of ESAT6/CFP10 's inhibitors for combating multi-drug resistant tuberculosis (MDR-TB)
Investigator(s):Sze KH, Yuen KY, Kao RYT
Department:Microbiology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2014


Project Title:Characterization of Staphylococcus aureus virulence factor EsxA and structure-based screening of EsxA's inhibitors for combating methicillin-resistant Staphylococcus aureus (MRSA)
Investigator(s):Sze KH, Kao RYT
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2014


Project Title:System Biology investigation on virulence factors of methicillin-resistant Staphylococcus aureus (MRSA)
Investigator(s):Sze KH, Yuen KY, Kao RYT
Department:Microbiology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2015


List of Research Outputs

HU X., Tse M.K., CHANG Y.Y., WANG Y., YANG Y., Li H., Sze K.H. and Sun H., The Disruption of Dimer RING Finger: Insight into the Therapeutic Properties of Arsenic(III) Trioxide, The 5th Asian Conference on Coordination Chemistry (ACCC-5), Hong Kong, July 12-16, 2014.
Lam C.W., Law C.Y., Sze K.H. and To K.K.W., Quantitative metabolomics of urine for rapid etiological diagnosis of urinary tract infection: Evaluation of a microbial-mammalian co-metabolite as a diagnostic biomarker., Clinica chimica acta. 2014, 438C: 24-28.
To K.K.W., Lee K.C., Wong S.S.Y., Lo K.C., Lui Y.M., Akhee S.J., Wu L., Ke Y., Law C.Y., Sze K.H., Lau S.K.P., Woo P.C.Y., Lam C.W. and Yuen K.Y., Lipid mediators of inflammation as novel plasma biomarkers to identify patients with bacteremia, Journal of Infection. 2015, 70: 433-444.
Woo P.C.Y., Lam C.W., Tam W.T., Lee K.C., Yung K.Y., Leung K.F., Sze K.H., Lau S.K.P. and Yuen K.Y., The biosynthetic pathway for a thousand-year-old natural food colorant and citrinin in Penicillium marneffei, Scientific Reports. 2014, 4: 6728.
Zhang B., HUA Y., Yu B., Lau C.Y., Cai J., Zheng S.Y., Yam W.C., Kao R.Y.T., Sze K.H., Zheng B., Yuen K.Y. and Huang J., Recombinant ESAT-6-Like Proteins Provoke Protective Immune Responses against Invasive Staphylococcus aureus Disease in a Murine Model, Infection and Immunity. 2015, 83: 339-345.


Researcher : TANG J

List of Research Outputs

GUO J., Zuo T., Cheng L., WU X., TANG J., Sun C.J., Feng L., Chen L., Zhang L.Q. and Chen Z., Simian Immunodeficiency Virus Infection Evades Vaccine-Elicited Antibody Responses to V2 Region, JAIDS Journal of Acquired Immune Deficiency Syndromes. 2015, 68: 502-510.


Researcher : TANG X

List of Research Outputs

LIANG J., Liu L., Chen M.A.N.D.Y., Li M.A.N.-.P.O., Li C.H.U.N.-.H.O., Chan C.H.U.N.-.C.H.U.N.G., TANG X., PENG J., Cheung K.W., Yam W.C. and Chen Z., Community-based HIV-1 Early Diagnosis and Risk Behavior Analysis of Men Having Sex with Men in Hong Kong, PLOS one. 2015, Apr 27;10: 4.


Researcher : TANG Y

List of Research Outputs

Teng L.L., Huang Y., Tse H., Chen J.H.K., TANG Y., Lau S.K.P. and Woo P.C.Y., Phylogenomic and MALDI-TOF MS analysis of Streptococcus sinensis HKU4T reveals a distinct phylogenetic clade in the genus Streptococcus, Genome Biology and Evolution. 2014, 6: 2930-2943.
Woo P.C.Y., Lau S.K.P., Teng L.L., Tsang K.L., Joseph M., Wong Y.M., TANG Y., Sivakumar S., BAI R., Wernery R., Wernery U. and Yuen K.Y., Metagenomic analysis of viromes of dromedary camel fecal samples reveals large number and high diversity of circoviruses and picobirnaviruses, Virology. 2014, 471-473: 117-125.


Researcher : TONG S

List of Research Outputs

Zhang G., Zong J., VERHOEVEN R.J.A., TONG S., Ji M., Cheng W., Lung M.L., Tsao G.S.W., Pan J. and Chen H., Characterization of extracellular secreted Epstein-Barr virus BART microRNAs as serological markers for nasopharyngeal carcinoma diagnosis and treatment, 16th International Symposium On Epstein-barr Virus And Associated Diseases, July 16-19, 2014, Brisbane, Australia. 2014.
Zhang G., Zong J., Lin S.H.A.O.J.U.N., VERHOEVEN R.J.A., TONG S., Chen Y., Ji M., Cheng W., Tsao G.S.W. and Lung M.L., Circulating Epstein-Barr virus microRNAs miR-BART7 and miR-BART13 as biomarkers for nasopharyngeal carcinoma diagnosis and treatment, International Journal of Cancer. 2014, n/a-n/a.


Researcher : TSANG CC

List of Research Outputs

Lam J.Y., Wu A.K., Leung W.S., Cheung I., TSANG C.C., Chen J.H.K., Chan J.F.W., Tse C.W., Lee R.A., Lau S.K.P. and Woo P.C.Y., Gordonia species as emerging causes of continuous ambulatory peritoneal dialysis-related peritonitis identified by 16S rRNA and secA1 genes sequencing and MALDI-TOF MS, Journal of Clinical Microbiology. 2015, 53: 671-676.
TSANG C.C., Chan J.F.W., Trendell-Smith N.J., Ngan A.H., Ling I.W., Lau S.K.P. and Woo P.C.Y., Subcutaneous phaeohyphomycosis in a patient with IgG4-related sclerosing disease caused by a novel ascomycete, Hongkongmyces pedis gen. et sp. nov.: first report of human infection associated with the family Lindgomycetaceae, Medical Mycology. 2014, 52: 736-747.
Woo P.C.Y., Wu A.K., TSANG C.C., Leung K.W., Ngan A.H., Curreem S.O.T., Lam K.W., Chen J.H.K., Chan J.F.W. and Lau S.K.P., Streptobacillus hongkongensis sp. nov., isolated from patients with quinsy and septic arthritis in Hong Kong and emended descriptions of the genus Streptobacillus and the species Streptobacillus moniliformis, International Journal of Systematic and Evolutionary Microbiology. 2014, 64: 3034-3039.


Researcher : Tam WT

List of Research Outputs

Lee K.C., Tam W.T., Lo K.C., Tsang K.L., Lau C.Y., To K.K.W., Chan J.F.W., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Metabolomics Analysis Reveals Specific Novel Tetrapeptide and Potential Anti-Inflammatory Metabolites in Pathogenic Aspergillus species, International Journal of Molecular Sciences. 2015, 16: 13850-13867.
Woo P.C.Y., Lau S.K.P., Martelli P., Hui S.W., Lau C.Y., Fan Y.Y., Groff J.M., Tam W.T., Chan K.H. and Yuen K.Y., Fatal systemic necrotizing infections associated with a novel paramyxovirus, anaconda paramyxovirus, in green anaconda juveniles, Journal of Clinical Microbiology. 2014, 52: 3614-3623.
Woo P.C.Y., Lam C.W., Tam W.T., Lee K.C., Yung K.Y., Leung K.F., Sze K.H., Lau S.K.P. and Yuen K.Y., The biosynthetic pathway for a thousand-year-old natural food colorant and citrinin in Penicillium marneffei, Scientific Reports. 2014, 4: 6728.


Researcher : Tan Z

List of Research Outputs

Tan Z., ZHOU J., Cheung K.L.A., Yu Z., Cheung K.W., Liang J., Wang H., LEE B.K., Man K., Liu L., Yuen K.Y. and Chen Z., Vaccine-Elicited CD8+ T Cells Cure Mesothelioma by Overcoming Tumor-Induced Immunosuppressive Environment, Cancer Research. 2014, 74: 6010-6021.


Researcher : Tang SF

List of Research Outputs

Chan W.S., Chan T.M., Lai T.W., Chan J.F.W., Lai R.W.M., Lai C.K.C. and Tang S.F., Complementary use of MALDI-TOF MS and real-time PCR-melt curve analysis for rapid identification of methicillin-resistant staphylococci and VRE, Journal of Antimicrobial Chemotherapy. 2015, 70: 441-447.


Researcher : Teng LL

Project Title:Usefulness of full sequence and 5' end 527-bp 16S ribosomal RNA gene sequencing for identification of medically important aerobic Gram-positive cocci
Investigator(s):Teng LL, Woo PCY, Lau SKP, Yuen KY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:09/2006


Project Title:The complete genome sequencing of Tsukamurella tyrosinosolvens, a bacterium associated with ophthalmologic infections
Investigator(s):Teng LL, Woo PCY, Lau SKP
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:06/2013


Project Title:Arginine deiminase pathway is far more important than urease for acid resistance in Laribacter hongkongensis: a possible result of arc gene cassette duplication
Investigator(s):Teng LL, Woo PCY, Lau SKP
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:01/2014


Project Title:The complete genome sequencing and phylogenomic analysis of Streptococcus sinensis, a novel bacterium associated with infective endocarditis
Investigator(s):Teng LL, Woo PCY, Lau SKP
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:10/2014


List of Research Outputs

Chen J.H.K., She K.K.K., Wong O.Y., Teng L.L., Yam W.C., Lau S.K.P., Woo P.C.Y., Cheng V.C.C. and Yuen K.Y., Use of MALDI Biotyper plus ClinProTools mass spectra analysis for correct identification of Streptococcus pneumoniae and Streptococcus mitis / oralis , Journal of Clinical Pathology. 2015, jclinpath-2014-202818.
Lau S.K.P., Teng L.L., Huang Y., Curreem S.O.T., Tsui S.K. and Woo P.C.Y., Draft Genome Sequence of Catabacter hongkongensis type strain HKU16T isolated from a patient with bacteremia and intestinal obstruction, Genome Announcements. 2015, 3: e00531-15.
Lau S.K.P., Wu A.K.L., Teng L.L., Tse H., Curreem S.O.T., Tsui S.K.W., Huang Y., Chen J.H.K., Lee R.A., Yuen K.Y. and Woo P.C.Y., Evidence for Elizabethkingia anophelis transmission from mother to infant, Hong Kong., Emerging Infectious Diseases. 2015, 21: 232-241.
Teng L.L., Huang Y., Tse H., Chen J.H.K., TANG Y., Lau S.K.P. and Woo P.C.Y., Phylogenomic and MALDI-TOF MS analysis of Streptococcus sinensis HKU4T reveals a distinct phylogenetic clade in the genus Streptococcus, Genome Biology and Evolution. 2014, 6: 2930-2943.
Woo P.C.Y., Lau S.K.P., Teng L.L., Tsang K.L., Joseph M., Wong Y.M., TANG Y., Sivakumar S., BAI R., Wernery R., Wernery U. and Yuen K.Y., Metagenomic analysis of viromes of dromedary camel fecal samples reveals large number and high diversity of circoviruses and picobirnaviruses, Virology. 2014, 471-473: 117-125.
Xiong L., Teng L.L., Watt R.M., Liu C., Lau S.K.P. and Woo P.C.Y., Molecular characterization of arginine deiminase pathway in Laribacter hongkongensis and unique regulation of arginine catabolism and anabolism by multiple environmental stresses, Environmental Microbiology. 2015.
Xiong L., Teng L.L., Lau S.K.P. and Woo P.C.Y., Molecular characterization of the arginine deiminase pathways in Laribacter hongkongensis: unique genetic organisation and regulation by transcriptional regulator ArgR and multiple environmental stresses, Microbial Stress Response Molecular Systems and Community Responses (Gordon Research Conferences), 2014 (South Hadley, MA, USA). 2014.


Researcher : To KKW

Project Title:Rapid detection of macrolide resistance amony Mycoplasma pneumoniae in Queen Mary Hospital
Investigator(s):To KKW, Ho PL, Chan KH, Hung IFN, Chiu SSS
Department:Microbiology
Source(s) of Funding:Queen Mary Hospital Charitable Trust - Training and Research Assistance Scheme
Start Date:07/2011


Project Title:Serological study of H7N9, H5N1 and H9N2 influenza among animal handlers
Investigator(s):To KKW, Hung IFN, Yuen KY, Chan JFW
Department:Microbiology
Source(s) of Funding:Centre for Health Protection
Start Date:09/2013


Project Title:Identification of innate immune defect predisposing to severe influenza in a Chinese population
Investigator(s):To KKW, Zhou J, Song Y, Hung IFN, Yuen KY
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:09/2013


Project Title:2014 Keystone Symposia Conference. Pathogenesis of Respiratory Viruses (J5); Surfactant protein B gene polymorphism is associated with severe influenza
Investigator(s):To KKW
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:01/2014


Project Title:ID week; The Use of Liquid Chromatography-Mass Spectrometry (LC-MS) for the Diagnosis of Community-Acquired Pneumonia
Investigator(s):To KKW
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2014
Completion Date:10/2014


List of Research Outputs

CHENG Z., Zhou J., To K.K.W., Chu H., Li C., Song Y., Zheng B. and Yuen K.Y., Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza., Journal of Infectious Diseases. 2015.
Chan J.F.W., Lau S.K.P., Wong S.C.Y., To K.K.W., Cheng V.C.C. and Yuen K.Y., Comparative analysis of patients with chronic pulmonary aspergillosis and invasive pulmonary aspergillosis: a ten-year retrospective study, 25th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2015), European Society of Clinical Microbiology and Infectious Diseases, Copenhagen, Denmark. 2015.
Chan J.F.W., To K.K.W., Chen H. and Yuen K.Y., Cross-species transmission and emergence of novel viruses from birds, Curr Opin Virol.. 2015, 10: 63-69.
Chan J.F.W., Lau S.K.P., To K.K.W., Cheng V.C.C., Woo P.C.Y. and Yuen K.Y., Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease, Clinical Microbiology Reviews. 2015, 28: 465-522.
Cheng V.C.C., Tai J.W., Lee W.M., Chan W.M., Wong S.C.Y., Chen J.H.K., Poon W.S.R., To K.K.W., Chan J.F.W., Ho P.L., Chan K.H. and Yuen K.Y., Infection Control Preparedness for Human Infection With Influenza A H7N9 in Hong Kong, Infection Control & Hospital Epidemiology. 2015, 36: 87-92.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Best Abstract in Clinical Medicine (Oral) - "Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial", 20th Medical Research Conference 2015, Department of Medicine, The University of Hong Kong . 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial, 20th Medical Research Conference, The University of Hong Kong, 17 Jan 2015. (Oral presentation - Best abstract in Clinical Medicine) . 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial, Clinical Infectious Diseases . 2014, 59(9): 1246-55.
Lam C.W., Law C.Y., Sze K.H. and To K.K.W., Quantitative metabolomics of urine for rapid etiological diagnosis of urinary tract infection: Evaluation of a microbial-mammalian co-metabolite as a diagnostic biomarker., Clinica chimica acta. 2014, 438C: 24-28.
Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Lau C.Y., Chow W.N., Ngan A.H., To K.K.W., Chan J.F.W., Hung I.F.N., Yam W.C., Yuen K.Y. and Woo P.C.Y., Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics: exploration of potential biomarkers, Emerging Microbes & Infections. 2015, 4: e6.
Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Lau C.Y., Chow W.N., Ngan A.H., To K.K.W., Chan J.F.W., Hung I.F.N., Yam W.C., Yuen K.Y. and Woo P.C.Y., Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics: exploration of potential biomarkers, Emerging Microbes and Infections. 2015, 4: e6.
Lee K.C., Tam W.T., Lo K.C., Tsang K.L., Lau C.Y., To K.K.W., Chan J.F.W., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Metabolomics Analysis Reveals Specific Novel Tetrapeptide and Potential Anti-Inflammatory Metabolites in Pathogenic Aspergillus species, International Journal of Molecular Sciences. 2015, 16: 13850-13867.
Li C., Li C., Zhang J., To K.K.W., Lee C.Y., Zhu H., Wu W.L., Chan J.F.W., Chen H., Hung I.F.N., Li L. and Yuen K.Y., Avian Influenza A H7N9 Virus Induces Severe Pneumonia in Mice without Prior Adaptation and Responds to a Combination of Zanamivir and COX-2 Inhibitor , PLoS One. 2014, 9(9): e107966.
Ng L.K., To K.K.W., Choi C.L., Yuen L.H., Yim S.M., Chan K.S.K., Lai J.S.M. and Wong Y.H.I., Predisposing Factors, Microbial Characteristics, and Clinical Outcome of Microbial Keratitis in a Tertiary Centre in Hong Kong: A 10-Year Experience, Journal of Ophthalmology. 2015, 2015: 1-9.
Nicholls J.M., Tsai P.N., Chan W.Y., Hui P.Y., Chan M.C.W., Peiris J.S.M., Chan K.H., Yuen K.Y. and To K.K.W., Fatal H7N9 pneumonia complicated by viral infection of a prosthetic cardiac valve – An autopsy study, Journal of Clinical Virology. 2014, 61(3): 466-9.
Sridhar S., To K.K.W., Chan J.F.W., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., A systematic approach to novel virus discovery in emerging infectious disease outbreaks, Journal of Molecular Diagnostics. 2015, 17: 230-241.
To K.K.W., Tse H., Chan W.M., CHOI K.Y., Zhang J., Sridhar S., Wong S.C.Y., Chan J.F.W., Chan S.F., Woo P.C.Y., Lau S.K.P., Lo J.Y., Chan K.H., Cheng V.C.C. and Yuen K.Y., A novel psittacine adenovirus identified during an outbreak of avian chlamydiosis and human psittacosis: zoonosis associated with virus-bacterium coinfection in birds, PLoS Neglected Tropical Diseases. 2014, 8: e3318.
To K.K.W., Chan J.F.W., Tsang K.L., Cheng V.C.C. and Yuen K.Y., Ebola virus disease: a highly fatal infectious disease reemerging in West Africa, Microbes and Infection. 2015, 17: 84-97.
To K.K.W., Immune Dysregulation in Severe Influenza, 2015.
To K.K.W., Lee K.C., Wong S.S.Y., Lo K.C., Lui Y.M., Akhee S.J., Wu L., Ke Y., Law C.Y., Sze K.H., Lau S.K.P., Woo P.C.Y., Lam C.W. and Yuen K.Y., Lipid mediators of inflammation as novel plasma biomarkers to identify patients with bacteremia, Journal of Infection. 2015, 70: 433-444.
To K.K.W., Mycophenolic acid has antiviral activity against different influenza virus subtypes affecting humans, 25th ECCMID, April 25-28, 2015, Copenhagen, Denmark Poster presentation. 2015.
To K.K.W., Zhang J., Chan S.F., LI C., Cai J., Lau C.Y., Li C., Akhee S.J., Wu W.L., Li L., Tsang K.L., Chan K.H., Chen H. and Yuen K.Y., Recombinant influenza A virus hemagglutinin HA2 subunit protects mice against influenza A(H7N9) virus infection, Archives of Virology. 2015, 160: 777-786.
To K.K.W., The Use of Liquid Chromatography-Mass Spectrometry (LC-MS) for the Diagnosis of Community-Acquired Pneumonia, ID week 2014, October 8-12, 2014 at the Pennsylvania Convention Center in Philadelphia, PA. Poster presentation. 2014.
To K.K.W., The potential of lipid mediators of inflammation as biomarkers for infectious diseases, 2015.
To K.K.W., Song W., Lau S.Y., Que T.L., Lung D.C., Hung I.F.N., Chen H. and Yuen K.Y., Unique reassortant of influenza A(H7N9) virus associated with severe disease emerging in Hong Kong, Journal of Infection. 2014, 69(1): 60-68.


Researcher : To WCS

Project Title:25th European Congress of Clinical Microbiology and Infectious Diseases; Molecular epidemiology and phylogenetic analysis of minor HIV-1 subtypes in Hong Kong: Emergence and spread of CRF07_BC and subtype C
Investigator(s):To WCS
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:04/2015
Completion Date:04/2015


List of Research Outputs

To W.C.S., Current molecular assays for HIV-1 antiretroviral therapy monitoring: challenges and possibilities, 8th Sino-American Conference on Infectious Diseases and 9th Annual Meeting of Chinese American Association for Clinical Microbiology. 2014.
To W.C.S., Chen J.H.K., Wong K.H., Chan K.C.W., Ng H.M. and Yam W.C., Molecular epidemiology and phylogenetic analysis of minor HIV-1 subtypes in Hong Kong: Emergence and spread of CRF07_BC and subtype C, 25th European Congress of Clinical Microbiology and Infectious Diseases. 2015.


Researcher : Tsang CL

List of Research Outputs

Tsang C.L., Chan J.F.W., Ip P.C.P., Ngan A.H.Y., Chen J.H.K., Lau S.K.P. and Woo P.C.Y., Subcutaneous Phaeohyphomycotic Nodule Due to Phialemoniopsis hongkongensis sp. nov., In: Alexander J. McAdam, MD, Journal of Clinical Microbiology. American Society for Microbiology (ASM), 2014, 52: 3280-3289.


Researcher : Tsang KL

List of Research Outputs

Lau S.K.P., Woo P.C.Y., Li K.S.M., Tsang K.L., Fan Y.Y., Luk K.H., Cai J., Chan K.H., Zheng B., Wang M. and Yuen K.Y., Discovery of a novel coronavirus, China Rattus coronavirus HKU24, from Norway rats supports murine origin of Betacoronavirus 1 with implications on the ancestor of Betacoronavirus lineage A, Journal of Virology. 2015, 89: 3076-3092.
Lee K.C., Tam W.T., Lo K.C., Tsang K.L., Lau C.Y., To K.K.W., Chan J.F.W., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Metabolomics Analysis Reveals Specific Novel Tetrapeptide and Potential Anti-Inflammatory Metabolites in Pathogenic Aspergillus species, International Journal of Molecular Sciences. 2015, 16: 13850-13867.
To K.K.W., Chan J.F.W., Tsang K.L., Cheng V.C.C. and Yuen K.Y., Ebola virus disease: a highly fatal infectious disease reemerging in West Africa, Microbes and Infection. 2015, 17: 84-97.
To K.K.W., Zhang J., Chan S.F., LI C., Cai J., Lau C.Y., Li C., Akhee S.J., Wu W.L., Li L., Tsang K.L., Chan K.H., Chen H. and Yuen K.Y., Recombinant influenza A virus hemagglutinin HA2 subunit protects mice against influenza A(H7N9) virus infection, Archives of Virology. 2015, 160: 777-786.
Wernery U., Corman V.M., Wong Y.M., Tsang K.L., Muth D., Khazanehdari K., Zirkel F., Ali M., Nagi P., Juhasz J., Wernery R., Joseph S., Syriac G., Elizabeth S.K., Patteril N.A., Woo P.C.Y. and Drosten C., Acute Middle East Respiratory Syndrome Coronavirus infection in livestock dromedaries, Dubai, 2014, Emerging Infectious Diseases. 2015, 21: 1019-1022.
Woo P.C.Y., Lau S.K.P., Teng L.L., Tsang K.L., Joseph M., Wong Y.M., TANG Y., Sivakumar S., BAI R., Wernery R., Wernery U. and Yuen K.Y., Metagenomic analysis of viromes of dromedary camel fecal samples reveals large number and high diversity of circoviruses and picobirnaviruses, Virology. 2014, 471-473: 117-125.


Researcher : Tsang LY

List of Research Outputs

Luo Y., Siu G.K.H., Yeung A.S.F., Chen J.H.K., Ho P.L., Leung K.W., Tsang L.Y., Cheng V.C.C., Guo L., Yang J., Ye L. and Yam W.C., Performance of the VITEK MS matrix-assisted laser desorption ionization-time of flight mass spectrometry system for rapid bacterial identification in two diagnostic centres in China, Journal of Medical Microbiology. 2015, 64: 18-24.


Researcher : Tse H

Project Title:Molecular characterization of antibiotic resistance in Staphylococcus lugdunensis isolates
Investigator(s):Tse H, Ho PL
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2014


Project Title:Molecular characterization of tetracycline resistance in Elizabethkingia anophelis
Investigator(s):Tse H, Lau SKP, Woo PCY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:06/2014


List of Research Outputs

Ho P.L., LEUNG M.H., Chow K.H., Tse C.W., Cheng V.C.C., Tse H., Mak S.K. and Lo W.K., Carriage niches and molecular epidemiology of Staphylococcus lugdunensis and methicillin-resistant S. lugdunensis among patients undergoing long-term renal replacement therapy, Diagnostic Microbiology and Infectious Disease. 2015, 81: 141-144.
Ho P.L., LEUNG M.H., Tse H., Chow K.H., Cheng V.C.C. and Que T.L., Novel Selective Medium for Isolation of Staphylococcus lugdunensis from Wound Specimens, Journal of Clinical Microbiology. 2014, 52: 2633-2636.
Lau S.K.P., Wu A.K.L., Teng L.L., Tse H., Curreem S.O.T., Tsui S.K.W., Huang Y., Chen J.H.K., Lee R.A., Yuen K.Y. and Woo P.C.Y., Evidence for Elizabethkingia anophelis transmission from mother to infant, Hong Kong., Emerging Infectious Diseases. 2015, 21: 232-241.
Teng L.L., Huang Y., Tse H., Chen J.H.K., TANG Y., Lau S.K.P. and Woo P.C.Y., Phylogenomic and MALDI-TOF MS analysis of Streptococcus sinensis HKU4T reveals a distinct phylogenetic clade in the genus Streptococcus, Genome Biology and Evolution. 2014, 6: 2930-2943.
To K.K.W., Tse H., Chan W.M., CHOI K.Y., Zhang J., Sridhar S., Wong S.C.Y., Chan J.F.W., Chan S.F., Woo P.C.Y., Lau S.K.P., Lo J.Y., Chan K.H., Cheng V.C.C. and Yuen K.Y., A novel psittacine adenovirus identified during an outbreak of avian chlamydiosis and human psittacosis: zoonosis associated with virus-bacterium coinfection in birds, PLoS Neglected Tropical Diseases. 2014, 8: e3318.


Researcher : Tse MK

List of Research Outputs

HU X., Tse M.K., CHANG Y.Y., WANG Y., YANG Y., Li H., Sze K.H. and Sun H., The Disruption of Dimer RING Finger: Insight into the Therapeutic Properties of Arsenic(III) Trioxide, The 5th Asian Conference on Coordination Chemistry (ACCC-5), Hong Kong, July 12-16, 2014.


Researcher : VERHOEVEN RJA

List of Research Outputs

Zhang G., Zong J., VERHOEVEN R.J.A., TONG S., Ji M., Cheng W., Lung M.L., Tsao G.S.W., Pan J. and Chen H., Characterization of extracellular secreted Epstein-Barr virus BART microRNAs as serological markers for nasopharyngeal carcinoma diagnosis and treatment, 16th International Symposium On Epstein-barr Virus And Associated Diseases, July 16-19, 2014, Brisbane, Australia. 2014.
Zhang G., Zong J., Lin S.H.A.O.J.U.N., VERHOEVEN R.J.A., TONG S., Chen Y., Ji M., Cheng W., Tsao G.S.W. and Lung M.L., Circulating Epstein-Barr virus microRNAs miR-BART7 and miR-BART13 as biomarkers for nasopharyngeal carcinoma diagnosis and treatment, International Journal of Cancer. 2014, n/a-n/a.


Researcher : WANG Y

List of Research Outputs

Ho P.L., Lo W.U., Lai E.L.Y., LAW Y.T., LEUNG M.H., WANG Y. and Chow K.H., Clonal diversity of CTX-M-producing, multidrug-resistant Escherichia coli from rodents, Journal of Medical Microbiology. 2015, 64: 185-190.


Researcher : WEN X

List of Research Outputs

Song W., Wang P., Mok B.W.Y., Lau S.Y., HUANG X., Wu W.L., ZHENG M., WEN X., Yang S., Chen Y., Li L., Yuen K.Y. and Chen H., The K526R substitution in viral protein ​PB2 enhances the effects of E627K on influenza virus replication, Nature Communications. 2014.


Researcher : WU H

List of Research Outputs

WU H., ZHANG X., Zhang H.J., Zhang Q., Chen Z., Huang J., Lee S.S. and Zheng B., In Vitro Selection of HIV-1 CRF08_BC Variants Resistant to Reverse Transcriptase Inhibitors , AIDS Research and Human Retroviruses. 2015, 31: 260-270.
ZHANG X., WU H., Zhang Q., Lau T.C.K., Chu H., Chen Z., Jin D. and Zheng B., A novel mutation, D404N, in the connection subdomain of reverse transcriptase of HIV-1 CRF08_BC subtype confers cross-resistance to NNRTIs, Journal of Antimicrobial Chemotherapy. 2015.


Researcher : WU X

List of Research Outputs

Cheng L., Tang X., Liu L., PENG J., Nishiura K., Cheung K.L.A., GUO J., WU X., Tang H., An M., ZHOU J., Cheung K.W., Wang H., Guan X., Wu Z. and Chen Z., Monoclonal antibodies specific to human Δ42PD1: A novel immunoregulator potentially involved in HIV-1 and tumor pathogenesis, mAbs. 2015, 7: 620-629.
GUO J., Zuo T., Cheng L., WU X., TANG J., Sun C.J., Feng L., Chen L., Zhang L.Q. and Chen Z., Simian Immunodeficiency Virus Infection Evades Vaccine-Elicited Antibody Responses to V2 Region, JAIDS Journal of Acquired Immune Deficiency Syndromes. 2015, 68: 502-510.


Researcher : Wang H

List of Research Outputs

Tan Z., ZHOU J., Cheung K.L.A., Yu Z., Cheung K.W., Liang J., Wang H., LEE B.K., Man K., Liu L., Yuen K.Y. and Chen Z., Vaccine-Elicited CD8+ T Cells Cure Mesothelioma by Overcoming Tumor-Induced Immunosuppressive Environment, Cancer Research. 2014, 74: 6010-6021.


Researcher : Wang P

List of Research Outputs

Song W., Wang P., Mok B.W.Y., Lau S.Y., HUANG X., Wu W.L., ZHENG M., WEN X., Yang S., Chen Y., Li L., Yuen K.Y. and Chen H., The K526R substitution in viral protein ​PB2 enhances the effects of E627K on influenza virus replication, Nature Communications. 2014.


Researcher : Wong KH

List of Research Outputs

Jiamsakul A., Sirivichayakul S., Ditangco R., Wong K.H., Li P.C.K., Praparattanapan J., Phanuphak P., Segubre-Mercado E., Yam W.C., Sirisanthana T., Singtoroj T. and Law M., Transmitted drug resistance in recently infected HIV-positive Individuals from four urban locations across Asia (2007–2010) – TASER-S, AIDS Research and Therapy. 2015, 12: 3.
To W.C.S., Chen J.H.K., Wong K.H., Chan K.C.W., Ng H.M. and Yam W.C., Molecular epidemiology and phylogenetic analysis of minor HIV-1 subtypes in Hong Kong: Emergence and spread of CRF07_BC and subtype C, 25th European Congress of Clinical Microbiology and Infectious Diseases. 2015.


Researcher : Wong LWM

Project Title:12th International Conference on Innate Immunity; Innate recognition of Sendai virus defective-interfering RNA
Investigator(s):Wong LWM
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2015


List of Research Outputs

Wong L.W.M., YUEN C.K. and Kok K.H., Innate recognition of Sendai virus defective-interfering RNA, 12th International Conference on Innate Immunity. 2015.


Researcher : Wong OY

List of Research Outputs

Chen J.H.K., She K.K.K., Wong O.Y., Teng L.L., Yam W.C., Lau S.K.P., Woo P.C.Y., Cheng V.C.C. and Yuen K.Y., Use of MALDI Biotyper plus ClinProTools mass spectra analysis for correct identification of Streptococcus pneumoniae and Streptococcus mitis / oralis , Journal of Clinical Pathology. 2015, jclinpath-2014-202818.


Researcher : Wong SCY

List of Research Outputs

Chan J.F.W., Lau S.K.P., Wong S.C.Y., To K.K.W., Cheng V.C.C. and Yuen K.Y., Comparative analysis of patients with chronic pulmonary aspergillosis and invasive pulmonary aspergillosis: a ten-year retrospective study, 25th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2015), European Society of Clinical Microbiology and Infectious Diseases, Copenhagen, Denmark. 2015.
Cheng V.C.C., Chen J.H.K., Poon R.W.S., Lee W.M., So S.Y.C., Wong S.C.Y., Chau P.H., Yip C.Y., Wong S.S.Y., Chan J.F.W., Hung I.F.N., Ho P.L. and Yuen K.Y., Control of hospital endemicity of multiple-drug-resistant Acinetobacter baumannii ST457 with directly observed hand hygiene, European Journal of Clinical Microbiology & Infectious Diseases. 2015, 34: 713-718.
Cheng V.C.C., Chen J.H.K., Tai J.W.M., Wong S.C.Y., Poon W.S.R., Hung I.F.N., Chan J.F.W., Ho P.L., Lo C.M. and Yuen K.Y., Decolonization of gastrointestinal carriage of vancomycin-resistant Enterococcus faecium: case series and review of literature, BMC Infectious Diseases. 2014, 14: 514.
Cheng V.C.C., Tai J.W., Lee W.M., Chan W.M., Wong S.C.Y., Chen J.H.K., Poon W.S.R., To K.K.W., Chan J.F.W., Ho P.L., Chan K.H. and Yuen K.Y., Infection Control Preparedness for Human Infection With Influenza A H7N9 in Hong Kong, Infection Control & Hospital Epidemiology. 2015, 36: 87-92.
To K.K.W., Tse H., Chan W.M., CHOI K.Y., Zhang J., Sridhar S., Wong S.C.Y., Chan J.F.W., Chan S.F., Woo P.C.Y., Lau S.K.P., Lo J.Y., Chan K.H., Cheng V.C.C. and Yuen K.Y., A novel psittacine adenovirus identified during an outbreak of avian chlamydiosis and human psittacosis: zoonosis associated with virus-bacterium coinfection in birds, PLoS Neglected Tropical Diseases. 2014, 8: e3318.


Researcher : Wong SSY

Project Title:Molecular characterization of streptococcus bovis bacteraemia
Investigator(s):Wong SSY, Yuen KY, Woo PCY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:11/2003


Project Title:Characterization of bacterial isolates with ambiguous biochemical profiles recovered from patients with clinically significant bacteremia by 16S rRNA gene sequencing, the state-of-the-art molecular technique for bacterial identification
Investigator(s):Wong SSY, Woo PCY, Lau SKP
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:11/2004


Project Title:Discovery and characterization of novel Tsukamurella species: a 14-year retrospective analysis
Investigator(s):Wong SSY, Teng LL, Lau SKP, Woo PCY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:06/2015


List of Research Outputs

Cheng V.C.C., Chen J.H.K., Poon R.W.S., Lee W.M., So S.Y.C., Wong S.C.Y., Chau P.H., Yip C.Y., Wong S.S.Y., Chan J.F.W., Hung I.F.N., Ho P.L. and Yuen K.Y., Control of hospital endemicity of multiple-drug-resistant Acinetobacter baumannii ST457 with directly observed hand hygiene, European Journal of Clinical Microbiology & Infectious Diseases. 2015, 34: 713-718.
To K.K.W., Lee K.C., Wong S.S.Y., Lo K.C., Lui Y.M., Akhee S.J., Wu L., Ke Y., Law C.Y., Sze K.H., Lau S.K.P., Woo P.C.Y., Lam C.W. and Yuen K.Y., Lipid mediators of inflammation as novel plasma biomarkers to identify patients with bacteremia, Journal of Infection. 2015, 70: 433-444.
Wong S.S.Y. and Wong S.C.Y., Ebola virus disease in nonendemic countries, Journal of the Formosan Medical Association. 2015, 114: 384-398.
Wong S.S.Y., Journal of the Formosan Medical Association, Journal of the Formosan Medical Association. Elsevier, 2014.
Wong S.S.Y., Fung K.S., Chau S., Poon R.W., Wong S.C. and Yuen K.Y., Molecular diagnosis in clinical parasitology: When and why?, Experimental Biology and Medicine. 2014, 239: 1443-1460.


Researcher : Wong YM

List of Research Outputs

Wernery U., Corman V.M., Wong Y.M., Tsang K.L., Muth D., Khazanehdari K., Zirkel F., Ali M., Nagi P., Juhasz J., Wernery R., Joseph S., Syriac G., Elizabeth S.K., Patteril N.A., Woo P.C.Y. and Drosten C., Acute Middle East Respiratory Syndrome Coronavirus infection in livestock dromedaries, Dubai, 2014, Emerging Infectious Diseases. 2015, 21: 1019-1022.
Woo P.C.Y., Lau S.K.P., Teng L.L., Tsang K.L., Joseph M., Wong Y.M., TANG Y., Sivakumar S., BAI R., Wernery R., Wernery U. and Yuen K.Y., Metagenomic analysis of viromes of dromedary camel fecal samples reveals large number and high diversity of circoviruses and picobirnaviruses, Virology. 2014, 471-473: 117-125.


Researcher : Woo P.C.Y.

Project Title:Molecular epidemiology of Exophiala infections in Hong Kong
Investigator(s):Woo PCY, Lau SKP, Yuen KY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:01/2013
Completion Date:12/2014


Project Title:Infection and Immunology
Investigator(s):Woo PCY, Yuen KY, Watt RM
Department:Microbiology
Source(s) of Funding:Seed Funding for Strategic Research Theme
Start Date:06/2013


Project Title:Nuclear ribosomal internal transcribed spacer (ITS) region as a DNA barcode for the identification of pathogenic fungi that are difficult to identify in clinical laboratories
Investigator(s):Woo PCY, Lau SKP, Yuen KY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:01/2014
Completion Date:12/2015


Project Title:Molecular epidemiology of superficial infections by non-dermatophytic moulds in Hong Kong
Investigator(s):Woo PCY, Lau SKP, Chan JFW
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:12/2014


List of Research Outputs



Researcher : Woo PCY

Project Title:Molecular epidemiology of Exophiala infections in Hong Kong
Investigator(s):Woo PCY, Lau SKP, Yuen KY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:01/2013
Completion Date:12/2014


Project Title:Infection and Immunology
Investigator(s):Woo PCY, Yuen KY, Watt RM
Department:Microbiology
Source(s) of Funding:Seed Funding for Strategic Research Theme
Start Date:06/2013


Project Title:Nuclear ribosomal internal transcribed spacer (ITS) region as a DNA barcode for the identification of pathogenic fungi that are difficult to identify in clinical laboratories
Investigator(s):Woo PCY, Lau SKP, Yuen KY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:01/2014
Completion Date:12/2015


Project Title:Molecular epidemiology of superficial infections by non-dermatophytic moulds in Hong Kong
Investigator(s):Woo PCY, Lau SKP, Chan JFW
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:12/2014


List of Research Outputs

Chan J.F.W., Lau S.K.P., To K.K.W., Cheng V.C.C., Woo P.C.Y. and Yuen K.Y., Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease, Clinical Microbiology Reviews. 2015, 28: 465-522.
Chen J.H.K., She K.K.K., Wong O.Y., Teng L.L., Yam W.C., Lau S.K.P., Woo P.C.Y., Cheng V.C.C. and Yuen K.Y., Use of MALDI Biotyper plus ClinProTools mass spectra analysis for correct identification of Streptococcus pneumoniae and Streptococcus mitis / oralis , Journal of Clinical Pathology. 2015, jclinpath-2014-202818.
Chen Y., Chan K.H., Kang Y., Chen H., Luk K.H., Poon R.W.S., Chan J.F.W., Yuen K.Y., Xia N., Lau S.K.P. and Woo P.C.Y., A sensitive and specific antigen detection assay for Middle East respiratory syndrome coronavirus, Emerging Microbes and Infections. 2015, 4: e26.
Lam J.Y., Wu A.K., Leung W.S., Cheung I., TSANG C.C., Chen J.H.K., Chan J.F.W., Tse C.W., Lee R.A., Lau S.K.P. and Woo P.C.Y., Gordonia species as emerging causes of continuous ambulatory peritoneal dialysis-related peritonitis identified by 16S rRNA and secA1 genes sequencing and MALDI-TOF MS, Journal of Clinical Microbiology. 2015, 53: 671-676.
Lau S.K.P., Chan S.Y., Curreem S.O.T., Hui S.W., Lau C.Y., Lee P., Ho C.C., Martelli P. and Woo P.C.Y., Burkholderia pseudomallei in soil samples from an oceanarium in Hong Kong detected using a sensitive PCR assay, Emerging Microbes and Infections. 2014, 3: e69.
Lau S.K.P., Woo P.C.Y., Yip C.Y., Li K.S.M., Fan Y.Y., BAI R., Huang Y., Chan K.H. and Yuen K.Y., Chickens host diverse picornaviruses originated from potential interspecies transmission with recombination, Journal of General Virology. 2014, 95: 1929-1944.
Lau S.K.P., Woo P.C.Y., Li K.S.M., Tsang K.L., Fan Y.Y., Luk K.H., Cai J., Chan K.H., Zheng B., Wang M. and Yuen K.Y., Discovery of a novel coronavirus, China Rattus coronavirus HKU24, from Norway rats supports murine origin of Betacoronavirus 1 with implications on the ancestor of Betacoronavirus lineage A, Journal of Virology. 2015, 89: 3076-3092.
Lau S.K.P., Teng L.L., Huang Y., Curreem S.O.T., Tsui S.K. and Woo P.C.Y., Draft Genome Sequence of Catabacter hongkongensis type strain HKU16T isolated from a patient with bacteremia and intestinal obstruction, Genome Announcements. 2015, 3: e00531-15.
Lau S.K.P., Wu A.K.L., Teng L.L., Tse H., Curreem S.O.T., Tsui S.K.W., Huang Y., Chen J.H.K., Lee R.A., Yuen K.Y. and Woo P.C.Y., Evidence for Elizabethkingia anophelis transmission from mother to infant, Hong Kong., Emerging Infectious Diseases. 2015, 21: 232-241.
Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Lau C.Y., Chow W.N., Ngan A.H., To K.K.W., Chan J.F.W., Hung I.F.N., Yam W.C., Yuen K.Y. and Woo P.C.Y., Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics: exploration of potential biomarkers, Emerging Microbes & Infections. 2015, 4: e6.
Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Lau C.Y., Chow W.N., Ngan A.H., To K.K.W., Chan J.F.W., Hung I.F.N., Yam W.C., Yuen K.Y. and Woo P.C.Y., Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics: exploration of potential biomarkers, Emerging Microbes and Infections. 2015, 4: e6.
Lau S.K.P., Sridhar S., Ho C.C., Chow W.N., Lee K.C., Lam C.W., Yuen K.Y. and Woo P.C.Y., Laboratory diagnosis of melioidosis: Past, present and future, Experimental Biology and Medicine. 2015, 240: 742-751.
Lee K.C., Tam W.T., Lo K.C., Tsang K.L., Lau C.Y., To K.K.W., Chan J.F.W., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Metabolomics Analysis Reveals Specific Novel Tetrapeptide and Potential Anti-Inflammatory Metabolites in Pathogenic Aspergillus species, International Journal of Molecular Sciences. 2015, 16: 13850-13867.
Li J., Liu F., Wang Q., Ge P., Woo P.C.Y., Yan J., Zhao Y., Gao G.F., Liu C.H. and Liu C., Genomic and transcriptomic analysis of NDM-1 Klebsiella pneumoniae in spaceflight reveal mechanisms underlying environmental adaptability, Scientific Reports. 2014, 4: 6216.
Nimmanee P., Woo P.C.Y., Kummasook A. and Vanittanakom N., Characterization of sakA gene from pathogenic dimorphic fungus Penicillium marneffei, International Journal of Medical Microbiology. 2015, 305: 62-74.
Nimmanee P., Woo P.C.Y., Vanittanakom P., Youngchim S. and Vanittanakom N., Functional analysis of atfA gene to stress response in pathogenic thermal dimorphic fungus Penicillium marneffei, PLoS One. 2014, 9: e111200.
Sridhar S., To K.K.W., Chan J.F.W., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., A systematic approach to novel virus discovery in emerging infectious disease outbreaks, Journal of Molecular Diagnostics. 2015, 17: 230-241.
Sridhar S., Luk H.K., Lau S.K.P. and Woo P.C.Y., First report of severe parainfluenza virus 4B and rhinovirus C coinfection in a liver transplant recipient treated with immunoglobulin, Journal of Clinical Virology. 2014, 61: 611-614.
Sridhar S., Lau S.K.P. and Woo P.C.Y., Hepatitis E: a disease of reemerging importance, Journal of Formosan Medical Association. 2015, 114: 681-690.
TSANG C.C., Chan J.F.W., Trendell-Smith N.J., Ngan A.H., Ling I.W., Lau S.K.P. and Woo P.C.Y., Subcutaneous phaeohyphomycosis in a patient with IgG4-related sclerosing disease caused by a novel ascomycete, Hongkongmyces pedis gen. et sp. nov.: first report of human infection associated with the family Lindgomycetaceae, Medical Mycology. 2014, 52: 736-747.
Teng L.L., Huang Y., Tse H., Chen J.H.K., TANG Y., Lau S.K.P. and Woo P.C.Y., Phylogenomic and MALDI-TOF MS analysis of Streptococcus sinensis HKU4T reveals a distinct phylogenetic clade in the genus Streptococcus, Genome Biology and Evolution. 2014, 6: 2930-2943.
To K.K.W., Tse H., Chan W.M., CHOI K.Y., Zhang J., Sridhar S., Wong S.C.Y., Chan J.F.W., Chan S.F., Woo P.C.Y., Lau S.K.P., Lo J.Y., Chan K.H., Cheng V.C.C. and Yuen K.Y., A novel psittacine adenovirus identified during an outbreak of avian chlamydiosis and human psittacosis: zoonosis associated with virus-bacterium coinfection in birds, PLoS Neglected Tropical Diseases. 2014, 8: e3318.
To K.K.W., Lee K.C., Wong S.S.Y., Lo K.C., Lui Y.M., Akhee S.J., Wu L., Ke Y., Law C.Y., Sze K.H., Lau S.K.P., Woo P.C.Y., Lam C.W. and Yuen K.Y., Lipid mediators of inflammation as novel plasma biomarkers to identify patients with bacteremia, Journal of Infection. 2015, 70: 433-444.
Tsang C.L., Chan J.F.W., Ip P.C.P., Ngan A.H.Y., Chen J.H.K., Lau S.K.P. and Woo P.C.Y., Subcutaneous Phaeohyphomycotic Nodule Due to Phialemoniopsis hongkongensis sp. nov., In: Alexander J. McAdam, MD, Journal of Clinical Microbiology. American Society for Microbiology (ASM), 2014, 52: 3280-3289.
Wang Q., Qi J., Yuan Y., Xuan Y., Han P., Wan Y., Ji W., Li Y., Wu Y., Wang J., Iwamoto A., Woo P.C.Y., Yuen K.Y., Yan J., Lu G. and Gao G.F., Bat origins of MERS-CoV supported by bat coronavirus HKU4 usage of human receptor CD26, Cell Host & Microbe. 2014, 16: 328-337.
Wang Q., Lau S.K.P., Liu F., Zhao Y., Li H.M., Li B.X., Hu Y.L., Woo P.C.Y. and Liu C.H., Molecular epidemiology and clinical characteristics of drug-resistant Mycobacterium tuberculosis in a tuberculosis referral hospital in China, PLoS One. 2014, 9: e110209.
Wernery U., Corman V.M., Wong Y.M., Tsang K.L., Muth D., Khazanehdari K., Zirkel F., Ali M., Nagi P., Juhasz J., Wernery R., Joseph S., Syriac G., Elizabeth S.K., Patteril N.A., Woo P.C.Y. and Drosten C., Acute Middle East Respiratory Syndrome Coronavirus infection in livestock dromedaries, Dubai, 2014, Emerging Infectious Diseases. 2015, 21: 1019-1022.
Woo P.C.Y., Croucher Senior Medical Research Fellowship, Croucher Foundation. 2015.
Woo P.C.Y., Editorial Board member, Scientific Reports, 2015.
Woo P.C.Y., Lau S.K.P., Martelli P., Hui S.W., Lau C.Y., Fan Y.Y., Groff J.M., Tam W.T., Chan K.H. and Yuen K.Y., Fatal systemic necrotizing infections associated with a novel paramyxovirus, anaconda paramyxovirus, in green anaconda juveniles, Journal of Clinical Microbiology. 2014, 52: 3614-3623.
Woo P.C.Y., Lau S.K.P., Teng L.L., Tsang K.L., Joseph M., Wong Y.M., TANG Y., Sivakumar S., BAI R., Wernery R., Wernery U. and Yuen K.Y., Metagenomic analysis of viromes of dromedary camel fecal samples reveals large number and high diversity of circoviruses and picobirnaviruses, Virology. 2014, 471-473: 117-125.
Woo P.C.Y., Wu A.K., TSANG C.C., Leung K.W., Ngan A.H., Curreem S.O.T., Lam K.W., Chen J.H.K., Chan J.F.W. and Lau S.K.P., Streptobacillus hongkongensis sp. nov., isolated from patients with quinsy and septic arthritis in Hong Kong and emended descriptions of the genus Streptobacillus and the species Streptobacillus moniliformis, International Journal of Systematic and Evolutionary Microbiology. 2014, 64: 3034-3039.
Woo P.C.Y., Lam C.W., Tam W.T., Lee K.C., Yung K.Y., Leung K.F., Sze K.H., Lau S.K.P. and Yuen K.Y., The biosynthetic pathway for a thousand-year-old natural food colorant and citrinin in Penicillium marneffei, Scientific Reports. 2014, 4: 6728.
Woo P.C.Y., What have we learned from Laribacter hongkongensis so far?, University of Electronic Science and Technology of China (Chengdu, China) . 2015.
Xie J., He J.B., Shi J.W., Xiao Q., Li L. and Woo P.C.Y., An adult zebrafish model for Laribacter hongkongensis infection: Koch’s postulates fulfilled, Emerging Microbes and Infections. 2014, 3: e73.
Xiong L., Teng L.L., Watt R.M., Liu C., Lau S.K.P. and Woo P.C.Y., Molecular characterization of arginine deiminase pathway in Laribacter hongkongensis and unique regulation of arginine catabolism and anabolism by multiple environmental stresses, Environmental Microbiology. 2015.
Xiong L., Teng L.L., Lau S.K.P. and Woo P.C.Y., Molecular characterization of the arginine deiminase pathways in Laribacter hongkongensis: unique genetic organisation and regulation by transcriptional regulator ArgR and multiple environmental stresses, Microbial Stress Response Molecular Systems and Community Responses (Gordon Research Conferences), 2014 (South Hadley, MA, USA). 2014.
Yang E., Chow W.N., Wang G., Woo P.C.Y., Lau S.K.P., Yuen K.Y., Lin X. and Cai J.J., Signature gene expression reveals novel clues to the molecular mechanisms of dimorphic transition in Penicillium marneffei, PLoS Genetics. 2014, 10: e1004662.
Yip C.Y., Lo K.L., Que T.L., Lee R.A., Chan K.H., Yuen K.Y., Woo P.C.Y. and Lau S.K.P., Epidemiology of human parechovirus, Aichi virus and salivirus in fecal samples from hospitalized children with gastroenteritis in Hong Kong, Virology Journal. 2014, 11: 182.


Researcher : Wu L

List of Research Outputs

To K.K.W., Lee K.C., Wong S.S.Y., Lo K.C., Lui Y.M., Akhee S.J., Wu L., Ke Y., Law C.Y., Sze K.H., Lau S.K.P., Woo P.C.Y., Lam C.W. and Yuen K.Y., Lipid mediators of inflammation as novel plasma biomarkers to identify patients with bacteremia, Journal of Infection. 2015, 70: 433-444.


Researcher : Wu WL

List of Research Outputs

Li C., Li C., Zhang J., To K.K.W., Lee C.Y., Zhu H., Wu W.L., Chan J.F.W., Chen H., Hung I.F.N., Li L. and Yuen K.Y., Avian Influenza A H7N9 Virus Induces Severe Pneumonia in Mice without Prior Adaptation and Responds to a Combination of Zanamivir and COX-2 Inhibitor , PLoS One. 2014, 9(9): e107966.
Song W., Wang P., Mok B.W.Y., Lau S.Y., HUANG X., Wu W.L., ZHENG M., WEN X., Yang S., Chen Y., Li L., Yuen K.Y. and Chen H., The K526R substitution in viral protein ​PB2 enhances the effects of E627K on influenza virus replication, Nature Communications. 2014.
To K.K.W., Zhang J., Chan S.F., LI C., Cai J., Lau C.Y., Li C., Akhee S.J., Wu W.L., Li L., Tsang K.L., Chan K.H., Chen H. and Yuen K.Y., Recombinant influenza A virus hemagglutinin HA2 subunit protects mice against influenza A(H7N9) virus infection, Archives of Virology. 2015, 160: 777-786.


Researcher : Xiong L

List of Research Outputs

Xiong L., Teng L.L., Watt R.M., Liu C., Lau S.K.P. and Woo P.C.Y., Molecular characterization of arginine deiminase pathway in Laribacter hongkongensis and unique regulation of arginine catabolism and anabolism by multiple environmental stresses, Environmental Microbiology. 2015.
Xiong L., Teng L.L., Lau S.K.P. and Woo P.C.Y., Molecular characterization of the arginine deiminase pathways in Laribacter hongkongensis: unique genetic organisation and regulation by transcriptional regulator ArgR and multiple environmental stresses, Microbial Stress Response Molecular Systems and Community Responses (Gordon Research Conferences), 2014 (South Hadley, MA, USA). 2014.


Researcher : YANG F

List of Research Outputs

CHEUNG N.N., Dai J., LAI K.K., YANG F. and Kao R.Y.T., Best Student Poster Award "Identification of a broad-spectrum inhibitor of common RNA respiratory viruses by high-throughput screening", The 28th International Conference on Antiviral Research (ICAR). 2015.


Researcher : YUEN CK

List of Research Outputs

Chan C.P., YUEN C.K., FUNG S.Y., KEW C., Zheng B., Yuen K.Y. and Jin D., Influenza A virus NS1 protein targets double-stranded RNA binding protein PACT to suppress innate antiviral response, Innate Immune Memory: A Wellcome Trust Scientific Conference. 2015.
Wong L.W.M., YUEN C.K. and Kok K.H., Innate recognition of Sendai virus defective-interfering RNA, 12th International Conference on Innate Immunity. 2015.


Researcher : Yam WC

List of Research Outputs

Chen J.H.K., She K.K.K., Wong O.Y., Teng L.L., Yam W.C., Lau S.K.P., Woo P.C.Y., Cheng V.C.C. and Yuen K.Y., Use of MALDI Biotyper plus ClinProTools mass spectra analysis for correct identification of Streptococcus pneumoniae and Streptococcus mitis / oralis , Journal of Clinical Pathology. 2015, jclinpath-2014-202818.
Ho P.L., Yam W.C., Leung C.C., Yew W.W., Mok T.Y., Chan K.S. and Tam C.M., Molecular tests for rapid detection of rifampicin and isoniazid resistance in Mycobacterium tuberculosis., Hong Kong Med J. 2015.
Jiamsakul A., Sirivichayakul S., Ditangco R., Wong K.H., Li P.C.K., Praparattanapan J., Phanuphak P., Segubre-Mercado E., Yam W.C., Sirisanthana T., Singtoroj T. and Law M., Transmitted drug resistance in recently infected HIV-positive Individuals from four urban locations across Asia (2007–2010) – TASER-S, AIDS Research and Therapy. 2015, 12: 3.
LAN Y., Lam J.T., Siu G.K.H., Yam W.C., Mason A.J. and Lam J.K.W., Cationic amphipathic D-enantiomeric antimicrobial peptides with in vitro and ex vivo activity against drug-resistant Mycobacterium tuberculosis, Tuberculosis. 2014, 94: 678-689.
LIANG J., Liu L., Chen M.A.N.D.Y., Li M.A.N.-.P.O., Li C.H.U.N.-.H.O., Chan C.H.U.N.-.C.H.U.N.G., TANG X., PENG J., Cheung K.W., Yam W.C. and Chen Z., Community-based HIV-1 Early Diagnosis and Risk Behavior Analysis of Men Having Sex with Men in Hong Kong, PLOS one. 2015, Apr 27;10: 4.
Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Lau C.Y., Chow W.N., Ngan A.H., To K.K.W., Chan J.F.W., Hung I.F.N., Yam W.C., Yuen K.Y. and Woo P.C.Y., Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics: exploration of potential biomarkers, Emerging Microbes & Infections. 2015, 4: e6.
Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Lau C.Y., Chow W.N., Ngan A.H., To K.K.W., Chan J.F.W., Hung I.F.N., Yam W.C., Yuen K.Y. and Woo P.C.Y., Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics: exploration of potential biomarkers, Emerging Microbes and Infections. 2015, 4: e6.
Leung C.C., Yam W.C., Ho P.L., Yew W.W., Chan C.K., Law W.S., Lee S.N., Chang K.C., Tai L.B. and Tam C.M., T-Spot. TB outperforms tuberculin skin test in predicting development of active tuberculosis among household contacts , Respirology. 2015, 20: 496-503.
Luo Y., Siu G.K.H., Yeung A.S.F., Chen J.H.K., Ho P.L., Leung K.W., Tsang L.Y., Cheng V.C.C., Guo L., Yang J., Ye L. and Yam W.C., Performance of the VITEK MS matrix-assisted laser desorption ionization-time of flight mass spectrometry system for rapid bacterial identification in two diagnostic centres in China, Journal of Medical Microbiology. 2015, 64: 18-24.
Siu G.K.H., Yam W.C., Zhang Y. and Kao R.Y.T., An Upstream Truncation of the furA-katG Operon Confers High-Level Isoniazid Resistance in a Mycobacterium tuberculosis Clinical Isolate with No Known Resistance-Associated Mutations, Antimicrobial Agents and Chemotherapy. 2014, 58: 6093-6100.
To W.C.S., Chen J.H.K., Wong K.H., Chan K.C.W., Ng H.M. and Yam W.C., Molecular epidemiology and phylogenetic analysis of minor HIV-1 subtypes in Hong Kong: Emergence and spread of CRF07_BC and subtype C, 25th European Congress of Clinical Microbiology and Infectious Diseases. 2015.
Zhang B., HUA Y., Yu B., Lau C.Y., Cai J., Zheng S.Y., Yam W.C., Kao R.Y.T., Sze K.H., Zheng B., Yuen K.Y. and Huang J., Recombinant ESAT-6-Like Proteins Provoke Protective Immune Responses against Invasive Staphylococcus aureus Disease in a Murine Model, Infection and Immunity. 2015, 83: 339-345.


Researcher : Yeung ML

Project Title:Dissecting the roles of tryptophanyl-tRNA synthetase and other host factors contributory to Enterovirus 71 (EV71) replication
Investigator(s):Yeung ML, Yip CY
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2013




Researcher : Yip CY

Project Title:Complete genome sequence analysis of human enterovirus 71 strains from 2004 to 2010 in Hong Kong
Investigator(s):Yip CY, Lau SKP, Woo PCY
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Mini Grants
Start Date:11/2011
Completion Date:08/2014


List of Research Outputs

Cheng V.C.C., Chen J.H.K., Poon R.W.S., Lee W.M., So S.Y.C., Wong S.C.Y., Chau P.H., Yip C.Y., Wong S.S.Y., Chan J.F.W., Hung I.F.N., Ho P.L. and Yuen K.Y., Control of hospital endemicity of multiple-drug-resistant Acinetobacter baumannii ST457 with directly observed hand hygiene, European Journal of Clinical Microbiology & Infectious Diseases. 2015, 34: 713-718.
Lau S.K.P., Woo P.C.Y., Yip C.Y., Li K.S.M., Fan Y.Y., BAI R., Huang Y., Chan K.H. and Yuen K.Y., Chickens host diverse picornaviruses originated from potential interspecies transmission with recombination, Journal of General Virology. 2014, 95: 1929-1944.
Yip C.Y., Lo K.L., Que T.L., Lee R.A., Chan K.H., Yuen K.Y., Woo P.C.Y. and Lau S.K.P., Epidemiology of human parechovirus, Aichi virus and salivirus in fecal samples from hospitalized children with gastroenteritis in Hong Kong, Virology Journal. 2014, 11: 182.


Researcher : Yu Z

List of Research Outputs

Tan Z., ZHOU J., Cheung K.L.A., Yu Z., Cheung K.W., Liang J., Wang H., LEE B.K., Man K., Liu L., Yuen K.Y. and Chen Z., Vaccine-Elicited CD8+ T Cells Cure Mesothelioma by Overcoming Tumor-Induced Immunosuppressive Environment, Cancer Research. 2014, 74: 6010-6021.


Researcher : Yuen K.Y.

Project Title:Establishment of core facilities for the HKU HIV/AIDS research laboratories
Investigator(s):Yuen KY, Zheng B, Woo PCY, Yam WC, Im SWK
Department:Microbiology
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:11/2001


Project Title:Bacteraemia caused by Anaerotruncus colihominis and emended description of the species
Investigator(s):Yuen KY, Lau SKP, Woo PCY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:09/2005


Project Title:Investigation of invasive Lasiodiplodia theobromae infections in humans
Investigator(s):Yuen KY, Tse H, Woo PCY, Lau SKP
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:09/2007


Project Title:Molecular epidemiological investigation of PARV-4-related viruses in HK and southern China
Investigator(s):Yuen KY, Tse H, Lau SKP, Woo PCY
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:10/2008


Project Title:Infection and Immunology
Investigator(s):Yuen KY
Department:Microbiology
Source(s) of Funding:Seed Funding for Strategic Research Theme
Start Date:11/2008


Project Title:Understanding the evolution and interspecies transmission of betacoronaviruses by structural and biophysical approaches
Investigator(s):Yuen KY, Woo PCY, Lau SKP, Chan JFW
Department:Microbiology
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2015


Project Title:Control of viral and multidrug resistant bacterial infections relevant to Hong Kong SAR
Investigator(s):Yuen KY, Jin D, Lau SKP, To KKW, Chan JFW, Sze KH, Tse H, Woo PCY, Hung IFN, Huang J, Ho PL, Kao RYT, Cheng VCC
Department:Microbiology
Source(s) of Funding:Commissioned Research on Control of Infectious Diseases (Phase III)
Start Date:01/2015


List of Research Outputs



Researcher : Yuen KY

Project Title:Establishment of core facilities for the HKU HIV/AIDS research laboratories
Investigator(s):Yuen KY, Zheng B, Woo PCY, Yam WC, Im SWK
Department:Microbiology
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:11/2001


Project Title:Bacteraemia caused by Anaerotruncus colihominis and emended description of the species
Investigator(s):Yuen KY, Lau SKP, Woo PCY
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:09/2005


Project Title:Investigation of invasive Lasiodiplodia theobromae infections in humans
Investigator(s):Yuen KY, Tse H, Woo PCY, Lau SKP
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:09/2007


Project Title:Molecular epidemiological investigation of PARV-4-related viruses in HK and southern China
Investigator(s):Yuen KY, Tse H, Lau SKP, Woo PCY
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:10/2008


Project Title:Infection and Immunology
Investigator(s):Yuen KY
Department:Microbiology
Source(s) of Funding:Seed Funding for Strategic Research Theme
Start Date:11/2008


Project Title:Understanding the evolution and interspecies transmission of betacoronaviruses by structural and biophysical approaches
Investigator(s):Yuen KY, Woo PCY, Lau SKP, Chan JFW
Department:Microbiology
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2015


Project Title:Control of viral and multidrug resistant bacterial infections relevant to Hong Kong SAR
Investigator(s):Yuen KY, Jin D, Lau SKP, To KKW, Chan JFW, Sze KH, Tse H, Woo PCY, Hung IFN, Huang J, Ho PL, Kao RYT, Cheng VCC
Department:Microbiology
Source(s) of Funding:Commissioned Research on Control of Infectious Diseases (Phase III)
Start Date:01/2015


List of Research Outputs

CHENG Z., Zhou J., To K.K.W., Chu H., Li C., Song Y., Zheng B. and Yuen K.Y., Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza., Journal of Infectious Diseases. 2015.
Chan C.P., YUEN C.K., FUNG S.Y., KEW C., Zheng B., Yuen K.Y. and Jin D., Influenza A virus NS1 protein targets double-stranded RNA binding protein PACT to suppress innate antiviral response, Innate Immune Memory: A Wellcome Trust Scientific Conference. 2015.
Chan J.F.W. and Yuen K.Y., A new ASPECT for complicated urinary tract infections, The Lancet. 2015, 385: 1920-1922.
Chan J.F.W., Chan K.H., Boudreaux D.M., Swanson M.D., Markovitz D.M. and Yuen K.Y., BanLec, a banana lectin, is a potent inhibitor of Middle East respiratory syndrome coronavirus in in vitro assays, IDWeek 2014, Infectious Diseases Society of America, Philadelphia, PA, USA. 2014.
Chan J.F.W., Lau S.K.P., Wong S.C.Y., To K.K.W., Cheng V.C.C. and Yuen K.Y., Comparative analysis of patients with chronic pulmonary aspergillosis and invasive pulmonary aspergillosis: a ten-year retrospective study, 25th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2015), European Society of Clinical Microbiology and Infectious Diseases, Copenhagen, Denmark. 2015.
Chan J.F.W., To K.K.W., Chen H. and Yuen K.Y., Cross-species transmission and emergence of novel viruses from birds, Curr Opin Virol.. 2015, 10: 63-69.
Chan J.F.W., Lau S.K.P., To K.K.W., Cheng V.C.C., Woo P.C.Y. and Yuen K.Y., Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease, Clinical Microbiology Reviews. 2015, 28: 465-522.
Chen J.H.K., She K.K.K., Wong O.Y., Teng L.L., Yam W.C., Lau S.K.P., Woo P.C.Y., Cheng V.C.C. and Yuen K.Y., Use of MALDI Biotyper plus ClinProTools mass spectra analysis for correct identification of Streptococcus pneumoniae and Streptococcus mitis / oralis , Journal of Clinical Pathology. 2015, jclinpath-2014-202818.
Chen Y., Chan K.H., Kang Y., Chen H., Luk K.H., Poon R.W.S., Chan J.F.W., Yuen K.Y., Xia N., Lau S.K.P. and Woo P.C.Y., A sensitive and specific antigen detection assay for Middle East respiratory syndrome coronavirus, Emerging Microbes and Infections. 2015, 4: e26.
Cheng V.C.C., Chen J.H.K., Poon R.W.S., Lee W.M., So S.Y.C., Wong S.C.Y., Chau P.H., Yip C.Y., Wong S.S.Y., Chan J.F.W., Hung I.F.N., Ho P.L. and Yuen K.Y., Control of hospital endemicity of multiple-drug-resistant Acinetobacter baumannii ST457 with directly observed hand hygiene, European Journal of Clinical Microbiology & Infectious Diseases. 2015, 34: 713-718.
Cheng V.C.C., Chen J.H.K., Tai J.W.M., Wong S.C.Y., Poon W.S.R., Hung I.F.N., Chan J.F.W., Ho P.L., Lo C.M. and Yuen K.Y., Decolonization of gastrointestinal carriage of vancomycin-resistant Enterococcus faecium: case series and review of literature, BMC Infectious Diseases. 2014, 14: 514.
Cheng V.C.C., Tai J.W., Lee W.M., Chan W.M., Wong S.C.Y., Chen J.H.K., Poon W.S.R., To K.K.W., Chan J.F.W., Ho P.L., Chan K.H. and Yuen K.Y., Infection Control Preparedness for Human Infection With Influenza A H7N9 in Hong Kong, Infection Control & Hospital Epidemiology. 2015, 36: 87-92.
Gao H.N., Yao H.P., Liang W.F., Wu X.X., Wu H.B., Wu N.P., Yang S.G., Zhang Q., Su K.K., Guo J., Zheng S.F., Zhu Y.X., Chen H., Yuen K.Y. and Li L.J., Viral genome and antiviral drug sensitivity analysis of two patients from a family cluster caused by the influenza A(H7N9) virus in Zhejiang, China, 2013, Int J Infect Dis.. 2014, 29(2014): 254-258.
Huang J., Zheng B. and Yuen K.Y., Live recombinant Salmonella oral vaccine against avian influenza viruses, Hong Kong Medical Journal. 2015, V21(3): 14-16.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Best Abstract in Clinical Medicine (Oral) - "Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial", 20th Medical Research Conference 2015, Department of Medicine, The University of Hong Kong . 2015.
Hung I.F.N., Chan K.H., Liang R.H.S., Lai T.S.T. and Yuen K.Y., Harvesting Convalescent Plasma for Hyperimmune Intravenous Globulin Production: A Multicentre Randomized Double-Blind Controlled Trial for Treatment of Patients with Serious S-OIV H1N1 Infection, Health Research Symposium 2014, Hong Kong, 15 Nov 2014. (Poster presentation). 2014.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial, 20th Medical Research Conference, The University of Hong Kong, 17 Jan 2015. (Oral presentation - Best abstract in Clinical Medicine) . 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial, Clinical Infectious Diseases . 2014, 59(9): 1246-55.
Lau S.K.P., Woo P.C.Y., Yip C.Y., Li K.S.M., Fan Y.Y., BAI R., Huang Y., Chan K.H. and Yuen K.Y., Chickens host diverse picornaviruses originated from potential interspecies transmission with recombination, Journal of General Virology. 2014, 95: 1929-1944.
Lau S.K.P., Woo P.C.Y., Li K.S.M., Tsang K.L., Fan Y.Y., Luk K.H., Cai J., Chan K.H., Zheng B., Wang M. and Yuen K.Y., Discovery of a novel coronavirus, China Rattus coronavirus HKU24, from Norway rats supports murine origin of Betacoronavirus 1 with implications on the ancestor of Betacoronavirus lineage A, Journal of Virology. 2015, 89: 3076-3092.
Lau S.K.P., Wu A.K.L., Teng L.L., Tse H., Curreem S.O.T., Tsui S.K.W., Huang Y., Chen J.H.K., Lee R.A., Yuen K.Y. and Woo P.C.Y., Evidence for Elizabethkingia anophelis transmission from mother to infant, Hong Kong., Emerging Infectious Diseases. 2015, 21: 232-241.
Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Lau C.Y., Chow W.N., Ngan A.H., To K.K.W., Chan J.F.W., Hung I.F.N., Yam W.C., Yuen K.Y. and Woo P.C.Y., Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics: exploration of potential biomarkers, Emerging Microbes & Infections. 2015, 4: e6.
Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Lau C.Y., Chow W.N., Ngan A.H., To K.K.W., Chan J.F.W., Hung I.F.N., Yam W.C., Yuen K.Y. and Woo P.C.Y., Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics: exploration of potential biomarkers, Emerging Microbes and Infections. 2015, 4: e6.
Lau S.K.P., Sridhar S., Ho C.C., Chow W.N., Lee K.C., Lam C.W., Yuen K.Y. and Woo P.C.Y., Laboratory diagnosis of melioidosis: Past, present and future, Experimental Biology and Medicine. 2015, 240: 742-751.
Lee K.C., Tam W.T., Lo K.C., Tsang K.L., Lau C.Y., To K.K.W., Chan J.F.W., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Metabolomics Analysis Reveals Specific Novel Tetrapeptide and Potential Anti-Inflammatory Metabolites in Pathogenic Aspergillus species, International Journal of Molecular Sciences. 2015, 16: 13850-13867.
Li C., Li C., Zhang J., To K.K.W., Lee C.Y., Zhu H., Wu W.L., Chan J.F.W., Chen H., Hung I.F.N., Li L. and Yuen K.Y., Avian Influenza A H7N9 Virus Induces Severe Pneumonia in Mice without Prior Adaptation and Responds to a Combination of Zanamivir and COX-2 Inhibitor , PLoS One. 2014, 9(9): e107966.
Nicholls J.M., Tsai P.N., Chan W.Y., Hui P.Y., Chan M.C.W., Peiris J.S.M., Chan K.H., Yuen K.Y. and To K.K.W., Fatal H7N9 pneumonia complicated by viral infection of a prosthetic cardiac valve – An autopsy study, Journal of Clinical Virology. 2014, 61(3): 466-9.
Song W., Wang P., Mok B.W.Y., Lau S.Y., HUANG X., Wu W.L., ZHENG M., WEN X., Yang S., Chen Y., Li L., Yuen K.Y. and Chen H., The K526R substitution in viral protein ​PB2 enhances the effects of E627K on influenza virus replication, Nature Communications. 2014.
Sridhar S., To K.K.W., Chan J.F.W., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., A systematic approach to novel virus discovery in emerging infectious disease outbreaks, Journal of Molecular Diagnostics. 2015, 17: 230-241.
Sridhar S., Chan J.F.W. and Yuen K.Y., Fatal anti-aquaporin-4 seropositive neuromyelitis optica spectrum disorder in tuberculosis, BMC Infectious Diseases. 2014, 14: 470.
Tan Z., ZHOU J., Cheung K.L.A., Yu Z., Cheung K.W., Liang J., Wang H., LEE B.K., Man K., Liu L., Yuen K.Y. and Chen Z., Vaccine-Elicited CD8+ T Cells Cure Mesothelioma by Overcoming Tumor-Induced Immunosuppressive Environment, Cancer Research. 2014, 74: 6010-6021.
To K.K.W., Tse H., Chan W.M., CHOI K.Y., Zhang J., Sridhar S., Wong S.C.Y., Chan J.F.W., Chan S.F., Woo P.C.Y., Lau S.K.P., Lo J.Y., Chan K.H., Cheng V.C.C. and Yuen K.Y., A novel psittacine adenovirus identified during an outbreak of avian chlamydiosis and human psittacosis: zoonosis associated with virus-bacterium coinfection in birds, PLoS Neglected Tropical Diseases. 2014, 8: e3318.
To K.K.W., Chan J.F.W., Tsang K.L., Cheng V.C.C. and Yuen K.Y., Ebola virus disease: a highly fatal infectious disease reemerging in West Africa, Microbes and Infection. 2015, 17: 84-97.
To K.K.W., Lee K.C., Wong S.S.Y., Lo K.C., Lui Y.M., Akhee S.J., Wu L., Ke Y., Law C.Y., Sze K.H., Lau S.K.P., Woo P.C.Y., Lam C.W. and Yuen K.Y., Lipid mediators of inflammation as novel plasma biomarkers to identify patients with bacteremia, Journal of Infection. 2015, 70: 433-444.
To K.K.W., Zhang J., Chan S.F., LI C., Cai J., Lau C.Y., Li C., Akhee S.J., Wu W.L., Li L., Tsang K.L., Chan K.H., Chen H. and Yuen K.Y., Recombinant influenza A virus hemagglutinin HA2 subunit protects mice against influenza A(H7N9) virus infection, Archives of Virology. 2015, 160: 777-786.
To K.K.W., Song W., Lau S.Y., Que T.L., Lung D.C., Hung I.F.N., Chen H. and Yuen K.Y., Unique reassortant of influenza A(H7N9) virus associated with severe disease emerging in Hong Kong, Journal of Infection. 2014, 69(1): 60-68.
Wang Q., Qi J., Yuan Y., Xuan Y., Han P., Wan Y., Ji W., Li Y., Wu Y., Wang J., Iwamoto A., Woo P.C.Y., Yuen K.Y., Yan J., Lu G. and Gao G.F., Bat origins of MERS-CoV supported by bat coronavirus HKU4 usage of human receptor CD26, Cell Host & Microbe. 2014, 16: 328-337.
Wong S.S.Y., Fung K.S., Chau S., Poon R.W., Wong S.C. and Yuen K.Y., Molecular diagnosis in clinical parasitology: When and why?, Experimental Biology and Medicine. 2014, 239: 1443-1460.
Woo P.C.Y., Lau S.K.P., Martelli P., Hui S.W., Lau C.Y., Fan Y.Y., Groff J.M., Tam W.T., Chan K.H. and Yuen K.Y., Fatal systemic necrotizing infections associated with a novel paramyxovirus, anaconda paramyxovirus, in green anaconda juveniles, Journal of Clinical Microbiology. 2014, 52: 3614-3623.
Woo P.C.Y., Lau S.K.P., Teng L.L., Tsang K.L., Joseph M., Wong Y.M., TANG Y., Sivakumar S., BAI R., Wernery R., Wernery U. and Yuen K.Y., Metagenomic analysis of viromes of dromedary camel fecal samples reveals large number and high diversity of circoviruses and picobirnaviruses, Virology. 2014, 471-473: 117-125.
Woo P.C.Y., Lam C.W., Tam W.T., Lee K.C., Yung K.Y., Leung K.F., Sze K.H., Lau S.K.P. and Yuen K.Y., The biosynthetic pathway for a thousand-year-old natural food colorant and citrinin in Penicillium marneffei, Scientific Reports. 2014, 4: 6728.
Yang E., Chow W.N., Wang G., Woo P.C.Y., Lau S.K.P., Yuen K.Y., Lin X. and Cai J.J., Signature gene expression reveals novel clues to the molecular mechanisms of dimorphic transition in Penicillium marneffei, PLoS Genetics. 2014, 10: e1004662.
Yip C.Y., Lo K.L., Que T.L., Lee R.A., Chan K.H., Yuen K.Y., Woo P.C.Y. and Lau S.K.P., Epidemiology of human parechovirus, Aichi virus and salivirus in fecal samples from hospitalized children with gastroenteritis in Hong Kong, Virology Journal. 2014, 11: 182.
Zhang B., HUA Y., Yu B., Lau C.Y., Cai J., Zheng S.Y., Yam W.C., Kao R.Y.T., Sze K.H., Zheng B., Yuen K.Y. and Huang J., Recombinant ESAT-6-Like Proteins Provoke Protective Immune Responses against Invasive Staphylococcus aureus Disease in a Murine Model, Infection and Immunity. 2015, 83: 339-345.


Researcher : ZHANG N

List of Research Outputs

ZHANG N., Zheng B., Lu L., Zhou Y., Jiang S. and Du L., Advancements in the development of subunit influenza vaccines, Microbes and Infection. 2015, 17: 123-134.


Researcher : ZHANG X

List of Research Outputs

WU H., ZHANG X., Zhang H.J., Zhang Q., Chen Z., Huang J., Lee S.S. and Zheng B., In Vitro Selection of HIV-1 CRF08_BC Variants Resistant to Reverse Transcriptase Inhibitors , AIDS Research and Human Retroviruses. 2015, 31: 260-270.
ZHANG X., WU H., Zhang Q., Lau T.C.K., Chu H., Chen Z., Jin D. and Zheng B., A novel mutation, D404N, in the connection subdomain of reverse transcriptase of HIV-1 CRF08_BC subtype confers cross-resistance to NNRTIs, Journal of Antimicrobial Chemotherapy. 2015.


Researcher : ZHAO H

List of Research Outputs

LEUNG H.C., Chan C.S., Poon K.M., ZHAO H., Cheung C.Y., Ng F., Huang J. and Zheng B., An H5N1-based matrix protein 2 ectodomain tetrameric peptide vaccine provides cross-protection against lethal infection with H7N9 influenza virus, Emerging Microbes & Infections. 2015, 4: e22.


Researcher : ZHENG M

List of Research Outputs

Song W., Wang P., Mok B.W.Y., Lau S.Y., HUANG X., Wu W.L., ZHENG M., WEN X., Yang S., Chen Y., Li L., Yuen K.Y. and Chen H., The K526R substitution in viral protein ​PB2 enhances the effects of E627K on influenza virus replication, Nature Communications. 2014.


Researcher : ZHOU J

List of Research Outputs

CHENG Z., Zhou J., To K.K.W., Chu H., Li C., Song Y., Zheng B. and Yuen K.Y., Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza., Journal of Infectious Diseases. 2015.
Cheng L., Tang X., Liu L., PENG J., Nishiura K., Cheung K.L.A., GUO J., WU X., Tang H., An M., ZHOU J., Cheung K.W., Wang H., Guan X., Wu Z. and Chen Z., Monoclonal antibodies specific to human Δ42PD1: A novel immunoregulator potentially involved in HIV-1 and tumor pathogenesis, mAbs. 2015, 7: 620-629.
Tan Z., ZHOU J., Cheung K.L.A., Yu Z., Cheung K.W., Liang J., Wang H., LEE B.K., Man K., Liu L., Yuen K.Y. and Chen Z., Vaccine-Elicited CD8+ T Cells Cure Mesothelioma by Overcoming Tumor-Induced Immunosuppressive Environment, Cancer Research. 2014, 74: 6010-6021.
Tang H.M.V., Gao W., Chan C.P., Cheng Y., Chaudhary V., Deng J., Yuen K.S., Wong C.M., Ng I.O.L., Kok K.H., Zhou J. and Jin D., Requirement of CRTC1 coactivator for hepatitis B virus transcription, Nucleic Acids Res. 2014, 42(20): 12455-68.


Researcher : Zhang H

Project Title:the 1st european conference of microbiology and immunology Low Th17 expression association with Chronic Hepatitis B viral infection by means of reducing viral specific IFNγ releasing in a HBV infection model of IL-17 KO mice
Investigator(s):Zhang H
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:05/2011




Researcher : Zhang J

Project Title:The expression and roles of functional leptin receptor (Ob-Rb) in proinflammatory responses induced by influenza viral infection.
Investigator(s):Zhang J
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:01/2015


List of Research Outputs

Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Best Abstract in Clinical Medicine (Oral) - "Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial", 20th Medical Research Conference 2015, Department of Medicine, The University of Hong Kong . 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial, 20th Medical Research Conference, The University of Hong Kong, 17 Jan 2015. (Oral presentation - Best abstract in Clinical Medicine) . 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial, Clinical Infectious Diseases . 2014, 59(9): 1246-55.
Li C., Li C., Zhang J., To K.K.W., Lee C.Y., Zhu H., Wu W.L., Chan J.F.W., Chen H., Hung I.F.N., Li L. and Yuen K.Y., Avian Influenza A H7N9 Virus Induces Severe Pneumonia in Mice without Prior Adaptation and Responds to a Combination of Zanamivir and COX-2 Inhibitor , PLoS One. 2014, 9(9): e107966.
To K.K.W., Tse H., Chan W.M., CHOI K.Y., Zhang J., Sridhar S., Wong S.C.Y., Chan J.F.W., Chan S.F., Woo P.C.Y., Lau S.K.P., Lo J.Y., Chan K.H., Cheng V.C.C. and Yuen K.Y., A novel psittacine adenovirus identified during an outbreak of avian chlamydiosis and human psittacosis: zoonosis associated with virus-bacterium coinfection in birds, PLoS Neglected Tropical Diseases. 2014, 8: e3318.
To K.K.W., Zhang J., Chan S.F., LI C., Cai J., Lau C.Y., Li C., Akhee S.J., Wu W.L., Li L., Tsang K.L., Chan K.H., Chen H. and Yuen K.Y., Recombinant influenza A virus hemagglutinin HA2 subunit protects mice against influenza A(H7N9) virus infection, Archives of Virology. 2015, 160: 777-786.
Wong D.K.H., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Zhang J., Hung I.F.N., Lai C.L. and Yuen R.M.F., Identification of Hepatitis B Virus DNA Polymerase Sequences to Predict Virological Response to Entecavir Therapy, Health Research Symposium 2014, Hong Kong, 15 Nov 2014. (Poster presentation). 2014.


Researcher : Zhang JX

Project Title:The expression and roles of functional leptin receptor (Ob-Rb) in proinflammatory responses induced by influenza viral infection.
Investigator(s):Zhang J
Department:Microbiology
Source(s) of Funding:Small Project Funding
Start Date:01/2015


List of Research Outputs



Researcher : Zhang M

Project Title:Reconstitution and Characterization of HIV-specific Antibody Repertoires in vitro: Implications for Passive Immunization
Investigator(s):Zhang M
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:08/2011
Completion Date:10/2014


Project Title:Development of a "Two-in-One" Duel Specific Antibody Therapeutics for Treatment of Breast Cancer
Investigator(s):Zhang M
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:11/2011




Researcher : Zheng B

Project Title:CCR5 expression on antigen-presenting cens in HIV infection
Investigator(s):Zheng B, Lee SS
Department:Microbiology
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:01/2001


Project Title:The pattern of chemokine receptor polymorphism in healthy and HIV positive Chinese adults
Investigator(s):Zheng B, Lee SS
Department:Microbiology
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:01/2001


Project Title:A longitudinal study of HIV-1 drug-resistance for improving management of patients on HARRT (MSS 140R)
Investigator(s):Zheng B, Lu L, Chan KW
Department:Microbiology
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:07/2006


Project Title:Study of vaccine HA-M2 against H5N1 avian influenza virus
Investigator(s):Zheng B
Department:Microbiology
Source(s) of Funding:Matching Fund for Hi-Tech Research and Development Program of China (863 Projects)
Start Date:08/2007


Project Title:Study of AAV- and peptide-based vaccine candidates against influenza virus H5N1 infection in animal model
Investigator(s):Zheng B, Yuen KY
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:11/2007


Project Title:Cross-protective efficacy of immunization with different forms of M2 vaccines and their combinations with HA vaccines against highly pathogenic H5N1 influenza A viruses in mice
Investigator(s):Zheng B, Yuen KY
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:10/2009


Project Title:Co-administration of antiviral and anti-inflammatory agents against avian influenza virus H5N1 infection in animal model
Investigator(s):Zheng B, Yuen KY, Jin D
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:01/2010
Completion Date:08/2014


Project Title:A feasibility study on anti-H5N1 influenza viral infection using aptamers targeting viral nucleoprotein
Investigator(s):Zheng B, Zhou J
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:11/2011
Completion Date:09/2014


Project Title:Development of Antiviral Agents based on Small RNA Containing Unique Motif (UIM/215)
Investigator(s):Zheng B, Zhou J
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:05/2012


Project Title:Development of Antiviral Agents based on Small RNA Containing Unique Motif
Investigator(s):Zheng B, Zhou J
Department:Microbiology
Source(s) of Funding:Matching Grant for Joint Research
Start Date:05/2012
Completion Date:04/2015


Project Title:Development of Antiviral Agents based on Small RNA Containing Unique Motif (UIM/215)
Investigator(s):Zheng B, Zhou J
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:05/2012


Project Title:Development of Antiviral Peptides against Infections of Influenza Virus and Other Respiratory Viruses
Investigator(s):Zheng B, Zhou J
Department:Microbiology
Source(s) of Funding:Matching Grant for Joint Research
Start Date:03/2013
Completion Date:02/2015


Project Title:Development of Antiviral Peptides against Infections of Influenza Virus and Other Respiratory Viruses
Investigator(s):Zheng B, Zhou J
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:11/2013


Project Title:Development of Antiviral Peptides against Infections of Influenza Virus and Other Respiratory Viruses
Investigator(s):Zheng B, Zhou J
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:11/2013


Project Title:International Microbiology Congresses of the International Union of Microbiological Societies (IUMS); Development of universal vaccines against H5N1 influenza based on different forms of M2 vaccines and their combinations with HA vaccines
Investigator(s):Zheng B
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:07/2014
Completion Date:08/2014


Project Title:Identification of ADCC epitopes on Hemagglutinin Antigen of Pandemic H1N1 Influenza Virus for Vaccine Development
Investigator(s):Zheng B
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:03/2015


List of Research Outputs

CHENG Z., Zhou J., To K.K.W., Chu H., Li C., Song Y., Zheng B. and Yuen K.Y., Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza., Journal of Infectious Diseases. 2015.
Chan C.P., YUEN C.K., FUNG S.Y., KEW C., Zheng B., Yuen K.Y. and Jin D., Influenza A virus NS1 protein targets double-stranded RNA binding protein PACT to suppress innate antiviral response, Innate Immune Memory: A Wellcome Trust Scientific Conference. 2015.
He B., Zheng B., Wang Q., Du L., Jiang S. and Lu L., Adenovirus-based vaccines against avian-origin H5N1 influenza viruses, Microbes and Infection. 2015, 17: 135-141.
Huang J., Zheng B. and Yuen K.Y., Live recombinant Salmonella oral vaccine against avian influenza viruses, Hong Kong Medical Journal. 2015, V21(3): 14-16.
LEUNG H.C., Chan C.S., Poon K.M., ZHAO H., Cheung C.Y., Ng F., Huang J. and Zheng B., An H5N1-based matrix protein 2 ectodomain tetrameric peptide vaccine provides cross-protection against lethal infection with H7N9 influenza virus, Emerging Microbes & Infections. 2015, 4: e22.
Lau S.K.P., Woo P.C.Y., Li K.S.M., Tsang K.L., Fan Y.Y., Luk K.H., Cai J., Chan K.H., Zheng B., Wang M. and Yuen K.Y., Discovery of a novel coronavirus, China Rattus coronavirus HKU24, from Norway rats supports murine origin of Betacoronavirus 1 with implications on the ancestor of Betacoronavirus lineage A, Journal of Virology. 2015, 89: 3076-3092.
Tong M., Fung T.M., Luk T.C.S., Ng K.Y., Lee K.W., Lin C., Yam J.W.P., Chan K.W., Ng F., Zheng B., Yuan Y.F., Xie D., Lo C.M., Man K., Guan X. and Ma S.K.Y., ANXA3/JNK Signaling Promotes Self-Renewal and Tumor Growth, and Its Blockade Provides a Therapeutic Target for Hepatocellular Carcinoma, Stem Cell Reports. 2015.
WU H., ZHANG X., Zhang H.J., Zhang Q., Chen Z., Huang J., Lee S.S. and Zheng B., In Vitro Selection of HIV-1 CRF08_BC Variants Resistant to Reverse Transcriptase Inhibitors , AIDS Research and Human Retroviruses. 2015, 31: 260-270.
ZHANG N., Zheng B., Lu L., Zhou Y., Jiang S. and Du L., Advancements in the development of subunit influenza vaccines, Microbes and Infection. 2015, 17: 123-134.
ZHANG X., WU H., Zhang Q., Lau T.C.K., Chu H., Chen Z., Jin D. and Zheng B., A novel mutation, D404N, in the connection subdomain of reverse transcriptase of HIV-1 CRF08_BC subtype confers cross-resistance to NNRTIs, Journal of Antimicrobial Chemotherapy. 2015.
Zhang B., HUA Y., Yu B., Lau C.Y., Cai J., Zheng S.Y., Yam W.C., Kao R.Y.T., Sze K.H., Zheng B., Yuen K.Y. and Huang J., Recombinant ESAT-6-Like Proteins Provoke Protective Immune Responses against Invasive Staphylococcus aureus Disease in a Murine Model, Infection and Immunity. 2015, 83: 339-345.


Researcher : Zheng B.

Project Title:CCR5 expression on antigen-presenting cens in HIV infection
Investigator(s):Zheng B, Lee SS
Department:Microbiology
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:01/2001


Project Title:The pattern of chemokine receptor polymorphism in healthy and HIV positive Chinese adults
Investigator(s):Zheng B, Lee SS
Department:Microbiology
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:01/2001


Project Title:A longitudinal study of HIV-1 drug-resistance for improving management of patients on HARRT (MSS 140R)
Investigator(s):Zheng B, Lu L, Chan KW
Department:Microbiology
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:07/2006


Project Title:Study of vaccine HA-M2 against H5N1 avian influenza virus
Investigator(s):Zheng B
Department:Microbiology
Source(s) of Funding:Matching Fund for Hi-Tech Research and Development Program of China (863 Projects)
Start Date:08/2007


Project Title:Study of AAV- and peptide-based vaccine candidates against influenza virus H5N1 infection in animal model
Investigator(s):Zheng B, Yuen KY
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:11/2007


Project Title:Cross-protective efficacy of immunization with different forms of M2 vaccines and their combinations with HA vaccines against highly pathogenic H5N1 influenza A viruses in mice
Investigator(s):Zheng B, Yuen KY
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:10/2009


Project Title:Co-administration of antiviral and anti-inflammatory agents against avian influenza virus H5N1 infection in animal model
Investigator(s):Zheng B, Yuen KY, Jin D
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:01/2010
Completion Date:08/2014


Project Title:A feasibility study on anti-H5N1 influenza viral infection using aptamers targeting viral nucleoprotein
Investigator(s):Zheng B, Zhou J
Department:Microbiology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:11/2011
Completion Date:09/2014


Project Title:Development of Antiviral Agents based on Small RNA Containing Unique Motif (UIM/215)
Investigator(s):Zheng B, Zhou J
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:05/2012


Project Title:Development of Antiviral Agents based on Small RNA Containing Unique Motif
Investigator(s):Zheng B, Zhou J
Department:Microbiology
Source(s) of Funding:Matching Grant for Joint Research
Start Date:05/2012
Completion Date:04/2015


Project Title:Development of Antiviral Agents based on Small RNA Containing Unique Motif (UIM/215)
Investigator(s):Zheng B, Zhou J
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:05/2012


Project Title:Development of Antiviral Peptides against Infections of Influenza Virus and Other Respiratory Viruses
Investigator(s):Zheng B, Zhou J
Department:Microbiology
Source(s) of Funding:Matching Grant for Joint Research
Start Date:03/2013
Completion Date:02/2015


Project Title:Development of Antiviral Peptides against Infections of Influenza Virus and Other Respiratory Viruses
Investigator(s):Zheng B, Zhou J
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:11/2013


Project Title:Development of Antiviral Peptides against Infections of Influenza Virus and Other Respiratory Viruses
Investigator(s):Zheng B, Zhou J
Department:Microbiology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:11/2013


Project Title:International Microbiology Congresses of the International Union of Microbiological Societies (IUMS); Development of universal vaccines against H5N1 influenza based on different forms of M2 vaccines and their combinations with HA vaccines
Investigator(s):Zheng B
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:07/2014
Completion Date:08/2014


Project Title:Identification of ADCC epitopes on Hemagglutinin Antigen of Pandemic H1N1 Influenza Virus for Vaccine Development
Investigator(s):Zheng B
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:03/2015


List of Research Outputs



Researcher : Zhou J

Project Title:A feasibility study on the inhibition of respiratory syncytial virus infection using siRNAs with a unique motif
Investigator(s):Zhou J, Zheng B
Department:Microbiology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2010


Project Title:Exploring the role of CD55 in the pathogenesis of influenza virus A infection
Investigator(s):Zhou J, Zheng B
Department:Microbiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2013


Project Title:A cell-based model to uncover the molecular underpinning of differential susceptibility and variable severity of human H7N9 influenza infection
Investigator(s):Zhou J, Song Y, To KKW
Department:Microbiology
Source(s) of Funding:Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential
Start Date:08/2014


Project Title:2nd International Conference on Epidemiology & Evolutionary Genetics; The CD55 genetic variations increase the disease severity of pandemic H1N1 (2009) influenza infection
Investigator(s):Zhou J
Department:Microbiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:08/2014
Completion Date:08/2014


List of Research Outputs

CHENG Z., Zhou J., To K.K.W., Chu H., Li C., Song Y., Zheng B. and Yuen K.Y., Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza., Journal of Infectious Diseases. 2015.
Cheng L., Tang X., Liu L., PENG J., Nishiura K., Cheung K.L.A., GUO J., WU X., Tang H., An M., ZHOU J., Cheung K.W., Wang H., Guan X., Wu Z. and Chen Z., Monoclonal antibodies specific to human Δ42PD1: A novel immunoregulator potentially involved in HIV-1 and tumor pathogenesis, mAbs. 2015, 7: 620-629.
Tan Z., ZHOU J., Cheung K.L.A., Yu Z., Cheung K.W., Liang J., Wang H., LEE B.K., Man K., Liu L., Yuen K.Y. and Chen Z., Vaccine-Elicited CD8+ T Cells Cure Mesothelioma by Overcoming Tumor-Induced Immunosuppressive Environment, Cancer Research. 2014, 74: 6010-6021.
Tang H.M.V., Gao W., Chan C.P., Cheng Y., Chaudhary V., Deng J., Yuen K.S., Wong C.M., Ng I.O.L., Kok K.H., Zhou J. and Jin D., Requirement of CRTC1 coactivator for hepatitis B virus transcription, Nucleic Acids Res. 2014, 42(20): 12455-68.


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