Dept of Biochemistry

DEPT OF BIOCHEMISTRY

Researcher : AO KL

List of Research Outputs

AO K.L., Studies on Polyphosphate Kinase 2 Mechanism and Inorganic Polyphosphate Function, M Phil Thesis, The University of Hong Kong. 2014.

Researcher : Au YK

Project Title:	Cartilage Biology & Pathology; Understanding the molecular impact of SOX9Y440X in campomelic dysplasia
Investigator(s):	Au YK
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2015
Completion Date:	03/2015

List of Research Outputs

YIP K.H.R., Au Y.K., Yang W., Cheung M.C.H., Chan D. and Cheah K.S.E., Towards Understanding Genetic and Molecular Etiology of Campomelic Dysplasia., 19th Research Postgraduate Symposium Hong Kong Dec 10-11, 2014.. 2014.

YIP K.H.R., Au Y.K., Yang W., Cheung M.C.H., Chan D. and Cheah K.S.E., Towards Understanding Genetic and Molecular Etiology of Campomelic Dysplasia, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

Researcher : Bao S

Project Title:	Prioritizing genes from runs of homozygosity associated with Alzheimer's disease by combined analysis of rare variants and gene networks
Investigator(s):	Bao S, Song Y, Zhou X
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	04/2015

List of Research Outputs

Lam J.H., Chow T.C., Siu K.L., Chau W.H., Ng M.H., Bao S., Ng G.C.T., Sham P.C. and Shum D.K.Y., PTPN exerts pro-neuronal survival and neuritic elongation via ErbB4/NRG3 signaling, Int J Biochem Cell Biol. 2015, 61: 53-62.

Plani-Lam J.H., Chow T.C., Siu K.L., Chau W.H., Ng M.H., Bao S., Ng C.T., Sham P.C., Shum D.K.Y., Jin D. and Song Y., PTPN21 exerts pro-neuronal survival and neuritic elongation via ErbB4/NRG3 signaling, The International Journal of Biochemistry & Cell Biology. Int J Biochem Cell Biol, 2015, 61: 53-62.

Researcher : Bevan SJ

List of Research Outputs

Bevan S.J., Chan W.L. and Tanner J.A., Building creative and collaborative assessment strategies into a large introductory biomedical sciences class – evidence for sustained deep learning and potential adaptability for MOOCs., 2014 East-West Alliance Global Symposia, Hong Kong. 2014.

Bevan S.J., Chan W.L. and Tanner J.A., Diverse assessment and active student engagement sustain deep learning: A comparative study of outcomes in two parallel introductory biochemistry courses, Biochemistry and Molecular Biology Education. 2014, 42: 474-479.

Researcher : Boyde TRC

List of Research Outputs

Waye M.M.Y., Baum L., Boyde T.R.C., Chan K.K.K., Cherny S.S., Choy F., Garcia-Barcelo M.M., Gong Z., Kagawa H., Kotaka M., Lee C.Y., Lee S.M.Y., Li H.Y., Meng H., Ng R.K., Ng T.B., Pollard J., Qi R., Shen D.W., Tam S.S.W., Tsang F.S.Y., Wasylyk B., Xue H. and Siu C.O., Genetics and Epigenetics of Bipolar Disorder, Journal of Biochemistry and Molecular Biology in the Post Genomic Era. 2014, 2 (2).

Researcher : CHENG Y

List of Research Outputs

CHENG Y., Tang H.M.V., GAO W., Deng J., Chan C.P. and Jin D., Ubiquitination and Proteosomedependent Degradation of the Activated Form of Human Liver-enriched Transcription Factor CREB- H, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

Tang H.M.V., Gao W., Chan C.P., Cheng Y., Chaudhary V., Deng J., Yuen K.S., Wong C.M., Ng I.O.L., Kok K.H., Zhou J. and Jin D., Requirement of CRTC1 coactivator for hepatitis B virus transcription, Nucleic Acids Res. 2014, 42(20): 12455-68.

Researcher : CHU TL

List of Research Outputs

CHU T.L., Genetic Analysis of the Role of MMP14 during Endochondral Ossification, M Phil Thesis, The University of Hong Kong. 2014.

Researcher : Cham WC

List of Research Outputs

Chow G.W., Cham W.C., Chan Y.S. and Shum D.K.Y., Role of proheparanase in regulating synaptic plasticity in rat hippocampus, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 77. 2015.

LAU W.Y., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Characterization of Heparanase 1 and Heparanase 2 at Hippocampus, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

LAU W.Y., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Role of heparanase 1 and heparanase 2 in modulating synaptic activities, Abstracts of 10th Int’l Symp. on Healthy Aging: 77. 2015.

Lam W.Y., Cham W.C., Chan Y.S. and Shum D.K.Y., Role of heparanase 1 and heparanase 2 in modulating synaptic activities, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 77. 2015.

Ma C.W., Han L., Cham W.C., Chan Y.S. and Shum D.K.Y., Neuronal proheparanase regulates synaptic function of the central vestibular system., Abstracts of 9^th FENS Forum of Neuroscience 1603. 2014.

Researcher : Chan CCY

Project Title:	Role of Sedlin in the control of endocytosis
Investigator(s):	Chan CCY, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013
Completion Date:	03/2015

Researcher : Chan CP

Project Title:	Roles of liver-enriched transcription factor CREB-H in liver fibrosis
Investigator(s):	Chan CP, Jin D
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	05/2014

Project Title:	Innate Immune Memory; INFLUENZA A VIRUS NS1 PROTEIN TARGETS DOUBLE STRANDED RNA-BINDING PROTEIN PACT TO SUPPRESS INNATE ANTIVIRAL RESPONSE
Investigator(s):	Chan CP
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2015
Completion Date:	03/2015

List of Research Outputs

CHENG Y., Tang H.M.V., GAO W., Deng J., Chan C.P. and Jin D., Ubiquitination and Proteosomedependent Degradation of the Activated Form of Human Liver-enriched Transcription Factor CREB- H, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

Chan C.P., Lui P.Y., FUNG S.Y. and Kok K.H., PACT targeting is a novel viral strategy of innate immune evasion, The 9th Chinese Society for Immunology Symposium. 2014.

FUNG S.Y., Chan C.P. and Jin D., Antiviral Activity of cGAMP against RNA Virus Infection, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

KEW C., Siu K.L., Chan C.P. and Kok K.H., Viral suppression of type I interferon production through PACT targeting, The Yin & Yang of the Interferon System. International Cytokine and Interferon Society Satellite Symposium. 2014.

Tang H.M.V., Gao W., Chan C.P., Cheng Y., Chaudhary V., Deng J., Yuen K.S., Wong C.M., Ng I.O.L., Kok K.H., Zhou J. and Jin D., Requirement of CRTC1 coactivator for hepatitis B virus transcription, Nucleic Acids Res. 2014, 42(20): 12455-68.

Yuen K.S., Chan C.P., Wong N.H.M., HO C.H., HO T.H., Lei T., Deng W., Tsao G.S.W., Chen H., Kok K.H. and Jin D., CRISPR/Cas9-mediated genome editing of Epstein-Barr virus in human cells, Journal of General Virology. 2015, 96: 626-636.

Researcher : Chan D

Project Title:	Genome-wide identification and functional studies of genetic risk factors for low back pain and intervertebral disc degeneration
Investigator(s):	Chan D
Department:	Biochemistry
Source(s) of Funding:	AOSpine International - General Award
Start Date:	08/2007

Project Title:	Research Output Prize (Li Ka Shing Faculty of Medicine)
Investigator(s):	Chan D
Department:	Biochemistry
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	12/2010

Project Title:	Interplay between ER stress and hypoxic stress in the regulation of chondrocyte differentiation
Investigator(s):	Chan D, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012

Project Title:	9th Pan Pacific Connective Tissue Societies Symposium - The extracellular Matrix niche
Investigator(s):	Chan D
Department:	Biochemistry
Source(s) of Funding:	Croucher Foundation - Conference / Seminars
Start Date:	11/2013

Project Title:	Integrative Approaches to Understanding Disorders of the Skeleton
Investigator(s):	Chan D
Department:	Biochemistry
Source(s) of Funding:	Croucher Advanced Study Institute
Start Date:	12/2013

Project Title:	Progenitor cells in the formation and repair of articular cartilage
Investigator(s):	Chan D, Cheah KSE, Chan BP
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Genetic and cellular basis of protective/regenerative mechanisms in skeletal tissues
Investigator(s):	Chan D
Department:	Biochemistry
Source(s) of Funding:	Croucher Senior Research Fellowships in Natural Sciences, Technology and Medicine
Start Date:	08/2014

Project Title:	Mechanisms of energy management in hypertrophic chondrocyte adaptation to ER Stress
Investigator(s):	Chan D, Chan BP, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

List of Research Outputs

Cheung J.P.Y., Samartzis D., Chan D., Cheah K.S.E. and Cheung K.M.C., 2014 Prize for Best Original Research by Trainees (Gold Medal): Genetic Predisposition of Lumbar Spinal Stenosis in Chinese: A Genome-wide Association Study, Hong Kong Academy of Medicine. 2014.

Cheung J.P.Y., Samartzis D., Kao P., Shigematsu P., Cheah K.S.E., Song Y., Sham P.C., Chan D. and Cheung K.M.C., Developmental lumbar spinal stenosis in Southern Chinese: findings from a genome-wide association study., Combined Academic Conference of the 18th Biennial Congress of the Asia Pacific Orthopaedic Association and the 36th Annual Meeting of the Royal College of Orthopaedic Surgeons of Thailand. Pattaya, Thailand. October 23-25, 2014.. 2014.

Cheung J.P.Y., Samartzis D., Kao P.Y.P., Shigematsu H., Cheah K.S.E., Song Y., Sham P.C., Chan D. and Cheung K.M.C., Developmental lumbar spinal stenosis in Southern Chinese: findings from a genome-wide association study, Combined Academic Conference of the 18th Biennial Congress of the Asia Pacific Orthopaedic Association and the 36th Annual Meeting of the Royal College of Orthopaedic Surgeons of Thailand. Pattaya, Thailand, 2014.

LAM Y., Feng C., Chan W.C.W., Chan B.P. and Chan D., Understanding the Contribution of Lgr5+ Interzone Progenitor Cells in Joint Repair, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

LI Y., Samartzis D., Campbell D., Cherny S., Cheung K.M.C., Luk K.D.K., Karppinen J., Song Y., Cheah K.S.E., Sham P.C. and Chan D., A novel pathway associated with lumbar disc degeneration: a genome-wide association study, 42nd Annual Meeting of International Society for the Study of the Lumbar Spine, San Francisco, USA, June 8-12, 2015.

LI Y., Kao P., Yip M.S., Sze K.L., Fosang A., McCulloch D., Cheung K.M.C., Samartzis D., Luk K.D.K., Karppinen J., Song Y., Cheah K.S.E., Sham P.C. and Chan D., Association and functional analysis of ADAMTSS in lumbar disc degeneration, 42nd Annual Meeting of International Society for the Study of the Lumbar Spine, San Francisco, USA, June 8-12, 2015.

Leung V.Y.L., Aladin Kaderbatcha D.M., Lv F., Tam V., Ngan A.H.W., Wu E.X., Luk K.D.K., Lu W.W., Masuda K., Chan D. and Cheung K.M.C., Mesenchymal stem cells reduce intervertebral disc fibrosis and facilitate repair, Stem Cells. 2014, 32(8): 2164-77.

Li Y., Samartzis D., Campbell D., Cherny S., Cheung K.M.C., Luk K.D.K., Karppinen J.I., Song Y., Cheah K.S.E., Sham P.C. and Chan D., A novel pathway associated with lumbar disc degeneration: a genome-wide association study, 42nd International Society for the Study of the Lumbar Spine. San Francisco, 2015.

Li Y., Kao P.Y.P., Yip M.S., Sze K.L., Fosang A., McCulloch D., Cheung K.M.C., Samartzis D., Luk K.D.K., Karppinen J.I., Song Y., Cheah K.S.E., Sham P.C. and Chan D., Association and functional analysis of ADAMTS5 in lumbar disc degeneration, 42nd International Society for the Study of the Lumbar Spine. San Francisco, 2015.

MA S.K.Y., Shen Y., Ng V.C.W., An Y., Agata K., Lam Y.W. and Chan D., Phylogenetic Analysis of Planarian Collagens and Their Roles in Regeneration, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

SUN Y., Lv M., Zheng Z., Chan D., Cheung K.M.C. and Leung V.Y.L., Enrichment Of Committed, Chondroitin Sulfate-expressing Human Nucleus Pulposus Cells Over Progenitors Under Alginate Encapsulation, 61st Annual Meeting of Orthopaedic Research Society. 2015.

SUN Y., Lv M., ZHOU L., Tam V., Lv F., Chan D., Wang H., Zheng Z., Cheung K.M.C. and Leung V.Y.L., Enrichment of committed human nucleus pulposus cells expressing chondroitin sulfate proteoglycans under alginate encapsulation, Osteoarthritis Cartilage. 2015, 23: 1194-1203.

SUN Y., Tsui Y.K., Kao R.Y.T., Chan D., Cheung K.M.C. and Leung V.Y.L., Screening Small Molecule Inhibitors Against Proteoglycan Degradation To Control Tissue Degeneration, 9th International Conference on Proteoglycans and 10th Pan-Pacific Connective Tissue Societies Symposium(ICP&PPCTSS 2015). 2015.

SUN Y., Masuda K., Chan D., Cheung K.M.C. and Leung V.Y.L., Small-molecule Suppressors of Proteoglycan Catabolism in Degenerative Disc Cells, 61st Annual Meeting of Orthopaedic Research Society. 2015.

Tam V., Yee F.Y.A., Sharma R., Cheung K.M.C., Cheah K.S.E., Lam Y.W. and Chan D., Disc cell responses to the local environment of degenerated and non-degenerated intervertebral disc tissue , Orthopaedic Research Society Annual Meeting, March 28th-31st, Las Vegas, USA. 2015.

To M.K.T., WONG K.W. and Chan D., Characterization of Molecular and Cellular Consequences in OI type V Osteoblasts, 12th International Conference on Osteogenesis Imperfecta. 2014.

Tsang K.Y., Chan D. and Cheah K.S.E., Fate of growth plate hypertrophic chondrocytes: Death or lineage extension?, Development, Growth & Differentiation. 2015, 57: 179-192.

YAO Q., Chan W.C.W., Ng V.C.W., Tan Z., Tsang K.Y., Cheah K.S.E. and Chan D., Hypertrophic Chondrocytes under ER Stress Utilizes the Hypoxia Stress Signals for Survival, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

YIP K.H.R., Au Y.K., Yang W., Cheung M.C.H., Chan D. and Cheah K.S.E., Towards Understanding Genetic and Molecular Etiology of Campomelic Dysplasia., 19th Research Postgraduate Symposium Hong Kong Dec 10-11, 2014.. 2014.

YIP K.H.R., Au Y.K., Yang W., Cheung M.C.H., Chan D. and Cheah K.S.E., Towards Understanding Genetic and Molecular Etiology of Campomelic Dysplasia, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

Yang L., Tsang K.Y., Tang H.C., Chan D. and Cheah K.S.E., Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation, Proc Nat Acad Sci. 2014, published ahead of print: doi:10.1073/pnas.1302703111.

Yang L., Tsang K.Y., Tang H.C., Chan D. and Cheah K.S.E., Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation, Proc Natl Acad Sci U S A. 2014, 111(33): 12097-102.

ZHANG Y., Song Y., Samartzis D., Bow C., Cheah K.S.E., Cheung M.C.H., Sham P.C., Chan D. and Leung K.K.H., Genetic risks for chronic periodontitis: preliminary data of a genome-wide association study., International Association for Dental Research Pan European Region Congress. Dubrovnik, Croatia. September 10-13, 2014.. 2014.

Zheng Y., Song Y., Samartzis D., Bow H.Y.C., Cheah K.S.E., Cheung K.M.C., Sham P.C., Chan D. and Leung W.K., Genetic risks for chronic periodontitis: preliminary data of a genome-wide association study, International Association for Dental Research Pan European Region Congress. Dubrovnik, Croatia, 2014.

Researcher : Chan D.

Project Title:	Genome-wide identification and functional studies of genetic risk factors for low back pain and intervertebral disc degeneration
Investigator(s):	Chan D
Department:	Biochemistry
Source(s) of Funding:	AOSpine International - General Award
Start Date:	08/2007

Project Title:	Research Output Prize (Li Ka Shing Faculty of Medicine)
Investigator(s):	Chan D
Department:	Biochemistry
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	12/2010

Project Title:	Interplay between ER stress and hypoxic stress in the regulation of chondrocyte differentiation
Investigator(s):	Chan D, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012

Project Title:	9th Pan Pacific Connective Tissue Societies Symposium - The extracellular Matrix niche
Investigator(s):	Chan D
Department:	Biochemistry
Source(s) of Funding:	Croucher Foundation - Conference / Seminars
Start Date:	11/2013

Project Title:	Integrative Approaches to Understanding Disorders of the Skeleton
Investigator(s):	Chan D
Department:	Biochemistry
Source(s) of Funding:	Croucher Advanced Study Institute
Start Date:	12/2013

Project Title:	Progenitor cells in the formation and repair of articular cartilage
Investigator(s):	Chan D, Cheah KSE, Chan BP
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Genetic and cellular basis of protective/regenerative mechanisms in skeletal tissues
Investigator(s):	Chan D
Department:	Biochemistry
Source(s) of Funding:	Croucher Senior Research Fellowships in Natural Sciences, Technology and Medicine
Start Date:	08/2014

Project Title:	Mechanisms of energy management in hypertrophic chondrocyte adaptation to ER Stress
Investigator(s):	Chan D, Chan BP, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

List of Research Outputs

Researcher : Chan JKM

Project Title:	Establishment of novel approaches to the study of the role of histone post-translational modifications in vivo
Investigator(s):	Chan KMJ
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2014

Project Title:	Epigenetics, Chromatin & Transcription; Epigenetics / Histone mutations in Human Disease
Investigator(s):	Chan KMJ
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2014

Project Title:	Functional analysis of the role of Mcm3 in epigenetic gene silencing
Investigator(s):	Chan KMJ
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Researcher : Chan WCW

Project Title:	Understanding the Differentiation of Inner Annulus Fibrosus Cells: An in vitro Approach
Investigator(s):	Chan WCW, Chan D
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	06/2015

List of Research Outputs

LAM Y., Feng C., Chan W.C.W., Chan B.P. and Chan D., Understanding the Contribution of Lgr5+ Interzone Progenitor Cells in Joint Repair, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

YAO Q., Chan W.C.W., Ng V.C.W., Tan Z., Tsang K.Y., Cheah K.S.E. and Chan D., Hypertrophic Chondrocytes under ER Stress Utilizes the Hypoxia Stress Signals for Survival, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Researcher : Chan WL

List of Research Outputs

Bevan S.J., Chan W.L. and Tanner J.A., Building creative and collaborative assessment strategies into a large introductory biomedical sciences class – evidence for sustained deep learning and potential adaptability for MOOCs., 2014 East-West Alliance Global Symposia, Hong Kong. 2014.

Bevan S.J., Chan W.L. and Tanner J.A., Diverse assessment and active student engagement sustain deep learning: A comparative study of outcomes in two parallel introductory biochemistry courses, Biochemistry and Molecular Biology Education. 2014, 42: 474-479.

Researcher : Chau WH

List of Research Outputs

Lam J.H., Chow T.C., Siu K.L., Chau W.H., Ng M.H., Bao S., Ng G.C.T., Sham P.C. and Shum D.K.Y., PTPN exerts pro-neuronal survival and neuritic elongation via ErbB4/NRG3 signaling, Int J Biochem Cell Biol. 2015, 61: 53-62.

Plani-Lam J.H., Chow T.C., Siu K.L., Chau W.H., Ng M.H., Bao S., Ng C.T., Sham P.C., Shum D.K.Y., Jin D. and Song Y., PTPN21 exerts pro-neuronal survival and neuritic elongation via ErbB4/NRG3 signaling, The International Journal of Biochemistry & Cell Biology. Int J Biochem Cell Biol, 2015, 61: 53-62.

Researcher : Chaudhary V

List of Research Outputs

Tang H.M.V., Gao W., Chan C.P., Cheng Y., Chaudhary V., Deng J., Yuen K.S., Wong C.M., Ng I.O.L., Kok K.H., Zhou J. and Jin D., Requirement of CRTC1 coactivator for hepatitis B virus transcription, Nucleic Acids Res. 2014, 42(20): 12455-68.

Researcher : Cheah K.S.E.

Project Title:	Defining the role of the transcription factor Sox9 in skeletal development by tissue-specific gene inactivation
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	UK/Hong Kong Joint Research Scheme
Start Date:	02/1998

Project Title:	4th Pan-Pacific Connective Tissues Societies Symposium Abnormal Regulation of Cartilage and Bone Growth in Transgenic Mice Expressing a Collagen X SMCD Mution
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/1999

Project Title:	Human Genome Meeting 2001 Genomic Analysis of the Mutant Locus in the Novel Transgenic Mouse Mutant, Yellow Submarine (ysb)
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2001

Project Title:	67th Cold Spring Harbor Symposium on Quantitative Biology - The Cardiovascular System An Essential Role for Type IIA Procollagen in Heart Development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2002

Project Title:	1st Annual Meeting of the American Society for Matrix Biology Type IIA Procollagen is Essential for Proper Heart Development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2002

Project Title:	The Gordon Research Conference on Cartilage Biology and Pathology Chondrocytes Survive ER Stress Caused by Unfolded Proteins and Differentiation is Re-programmed
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2005

Project Title:	11th Human Genome Meeting Procollagen IIA Facilitates BMP Signaling in Heart Development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2006

Project Title:	Cold Spring Harbor Laboratory Meeting on Mouse Molecular Genetics Insight into the Molecular Pathogenesis of Campomelic Dysplasia Received By A Conditional SOX9 Mutant Mouse Model
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2006

Project Title:	Role of Sox2 in the stemness of dermal precursors
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2010

Project Title:	Genetic analyses of sensory fate determination in inner ear development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2010
Completion Date:	08/2014

Project Title:	Hong Kong Society for Developmental Biology Symposium - from Embryology to Disease Mechanisms
Investigator(s):	Cheah KSE, Lui VCH
Department:	Biochemistry
Source(s) of Funding:	Croucher Foundation - Conference / Seminars
Start Date:	11/2012

Project Title:	Functional analyses of how genomic variation affects personal risk for degenerative skeletal disorders
Investigator(s):	Cheah KSE, Chan BP, Chan D, Cheung KMC, Jin D, Lian Q, Luk KDK, Sham PC, Zhang MQ, Cherny SS, Huang J, Ng RK, Samartzis D, Song Y, Wang JJ
Department:	Biochemistry
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	01/2013

Project Title:	Genetic analyses of the roles of Sox2 and Sox18 in hair follicle development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	Stem cells: Niches, Regeneration & Repair
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Croucher Advanced Study Institute
Start Date:	03/2013

Project Title:	Development and Reproduction
Investigator(s):	Cheah KSE, Ng EHY, Wu EX
Department:	Biochemistry
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	06/2013

Project Title:	Identifying critical transitions and gene regulatory networks controlling phases of chondrocyte differentiation in the growth plate
Investigator(s):	Cheah KSE, Wang JJ, Chan D, Ng RK
Department:	Biochemistry
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2014

Project Title:	Mechanistic insights into the genesis and physiological role of hypertrophic chondrocyte-derived osteoblasts
Investigator(s):	Cheah KSE, Chan D
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Craniofacial Morphogenesis & Tissue Regeneration; Transcriptional control of sensory progenitor specification in the inner ear
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2014

Project Title:	Mechanisms controlling determination of sensory versus non-sensory fate in inner ear development
Investigator(s):	Cheah KSE, Wong YME, Jin D
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2014

Project Title:	Global Spine Congress 2015; The changing RNAome of the developing nucleus pulposus of the intervertebral disc - implications for Intervertebral Disc Disease
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2015

List of Research Outputs

Researcher : Cheah KSE

Project Title:	Defining the role of the transcription factor Sox9 in skeletal development by tissue-specific gene inactivation
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	UK/Hong Kong Joint Research Scheme
Start Date:	02/1998

Project Title:	4th Pan-Pacific Connective Tissues Societies Symposium Abnormal Regulation of Cartilage and Bone Growth in Transgenic Mice Expressing a Collagen X SMCD Mution
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/1999

Project Title:	Human Genome Meeting 2001 Genomic Analysis of the Mutant Locus in the Novel Transgenic Mouse Mutant, Yellow Submarine (ysb)
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2001

Project Title:	67th Cold Spring Harbor Symposium on Quantitative Biology - The Cardiovascular System An Essential Role for Type IIA Procollagen in Heart Development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2002

Project Title:	1st Annual Meeting of the American Society for Matrix Biology Type IIA Procollagen is Essential for Proper Heart Development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2002

Project Title:	The Gordon Research Conference on Cartilage Biology and Pathology Chondrocytes Survive ER Stress Caused by Unfolded Proteins and Differentiation is Re-programmed
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2005

Project Title:	11th Human Genome Meeting Procollagen IIA Facilitates BMP Signaling in Heart Development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2006

Project Title:	Cold Spring Harbor Laboratory Meeting on Mouse Molecular Genetics Insight into the Molecular Pathogenesis of Campomelic Dysplasia Received By A Conditional SOX9 Mutant Mouse Model
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2006

Project Title:	Role of Sox2 in the stemness of dermal precursors
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2010

Project Title:	Genetic analyses of sensory fate determination in inner ear development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2010
Completion Date:	08/2014

Project Title:	Hong Kong Society for Developmental Biology Symposium - from Embryology to Disease Mechanisms
Investigator(s):	Cheah KSE, Lui VCH
Department:	Biochemistry
Source(s) of Funding:	Croucher Foundation - Conference / Seminars
Start Date:	11/2012

Project Title:	Functional analyses of how genomic variation affects personal risk for degenerative skeletal disorders
Investigator(s):	Cheah KSE, Chan BP, Chan D, Cheung KMC, Jin D, Lian Q, Luk KDK, Sham PC, Zhang MQ, Cherny SS, Huang J, Ng RK, Samartzis D, Song Y, Wang JJ
Department:	Biochemistry
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	01/2013

Project Title:	Genetic analyses of the roles of Sox2 and Sox18 in hair follicle development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	Stem cells: Niches, Regeneration & Repair
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Croucher Advanced Study Institute
Start Date:	03/2013

Project Title:	Development and Reproduction
Investigator(s):	Cheah KSE, Ng EHY, Wu EX
Department:	Biochemistry
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	06/2013

Project Title:	Identifying critical transitions and gene regulatory networks controlling phases of chondrocyte differentiation in the growth plate
Investigator(s):	Cheah KSE, Wang JJ, Chan D, Ng RK
Department:	Biochemistry
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2014

Project Title:	Mechanistic insights into the genesis and physiological role of hypertrophic chondrocyte-derived osteoblasts
Investigator(s):	Cheah KSE, Chan D
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Craniofacial Morphogenesis & Tissue Regeneration; Transcriptional control of sensory progenitor specification in the inner ear
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2014

Project Title:	Mechanisms controlling determination of sensory versus non-sensory fate in inner ear development
Investigator(s):	Cheah KSE, Wong YME, Jin D
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2014

Project Title:	Global Spine Congress 2015; The changing RNAome of the developing nucleus pulposus of the intervertebral disc - implications for Intervertebral Disc Disease
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2015

List of Research Outputs

Cheah K.S.E., Asian Editor, In: Organogenesis and Morphogenesis, Development, Growth & Differentiation. 2015, 57(2).

Cheung J.P.Y., Samartzis D., Chan D., Cheah K.S.E. and Cheung K.M.C., 2014 Prize for Best Original Research by Trainees (Gold Medal): Genetic Predisposition of Lumbar Spinal Stenosis in Chinese: A Genome-wide Association Study, Hong Kong Academy of Medicine. 2014.

Cheung J.P.Y., Samartzis D., Kao P., Shigematsu P., Cheah K.S.E., Song Y., Sham P.C., Chan D. and Cheung K.M.C., Developmental lumbar spinal stenosis in Southern Chinese: findings from a genome-wide association study., Combined Academic Conference of the 18th Biennial Congress of the Asia Pacific Orthopaedic Association and the 36th Annual Meeting of the Royal College of Orthopaedic Surgeons of Thailand. Pattaya, Thailand. October 23-25, 2014.. 2014.

Cheung J.P.Y., Samartzis D., Kao P.Y.P., Shigematsu H., Cheah K.S.E., Song Y., Sham P.C., Chan D. and Cheung K.M.C., Developmental lumbar spinal stenosis in Southern Chinese: findings from a genome-wide association study, Combined Academic Conference of the 18th Biennial Congress of the Asia Pacific Orthopaedic Association and the 36th Annual Meeting of the Royal College of Orthopaedic Surgeons of Thailand. Pattaya, Thailand, 2014.

Cheung M.C.H., HO S.H., Hui M.N., Wu M.H., Cheung M.P.L., Ho C.K.Y., Niu B., Cheah K.S.E. and LIU A., Sox9 and the Molecular Network Regulating Neural Crest Cell Motility, 2014 International SOX Research Conference. 2014.

LI Y., Samartzis D., Campbell D., Cherny S., Cheung K.M.C., Luk K.D.K., Karppinen J., Song Y., Cheah K.S.E., Sham P.C. and Chan D., A novel pathway associated with lumbar disc degeneration: a genome-wide association study, 42nd Annual Meeting of International Society for the Study of the Lumbar Spine, San Francisco, USA, June 8-12, 2015.

LI Y., Kao P., Yip M.S., Sze K.L., Fosang A., McCulloch D., Cheung K.M.C., Samartzis D., Luk K.D.K., Karppinen J., Song Y., Cheah K.S.E., Sham P.C. and Chan D., Association and functional analysis of ADAMTSS in lumbar disc degeneration, 42nd Annual Meeting of International Society for the Study of the Lumbar Spine, San Francisco, USA, June 8-12, 2015.

Li Y., Samartzis D., Campbell D., Cherny S., Cheung K.M.C., Luk K.D.K., Karppinen J.I., Song Y., Cheah K.S.E., Sham P.C. and Chan D., A novel pathway associated with lumbar disc degeneration: a genome-wide association study, 42nd International Society for the Study of the Lumbar Spine. San Francisco, 2015.

Li Y., Kao P.Y.P., Yip M.S., Sze K.L., Fosang A., McCulloch D., Cheung K.M.C., Samartzis D., Luk K.D.K., Karppinen J.I., Song Y., Cheah K.S.E., Sham P.C. and Chan D., Association and functional analysis of ADAMTS5 in lumbar disc degeneration, 42nd International Society for the Study of the Lumbar Spine. San Francisco, 2015.

Lian Q., Zhang Y., ZHANG Z. and Cheah K.S.E., Differentiation of human notochordal-like cells from human pluripotent stem cells, ISSCR. 2015.

Tam V., Yee F.Y.A., Sharma R., Cheung K.M.C., Cheah K.S.E., Lam Y.W. and Chan D., Disc cell responses to the local environment of degenerated and non-degenerated intervertebral disc tissue , Orthopaedic Research Society Annual Meeting, March 28th-31st, Las Vegas, USA. 2015.

Tsang K.Y., Chan D. and Cheah K.S.E., Fate of growth plate hypertrophic chondrocytes: Death or lineage extension?, Development, Growth & Differentiation. 2015, 57: 179-192.

WEN S., Tan Z., Hui C.C. and Cheah K.S.E., Functional Roles for Irx3 and Irx5 in Skeletal Development, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

WEN S., Tan Z., Hui C.C. and Cheah K.S.E., Functional roles for Irx3 and Irx5 in osteoblast differentiation, Cold Spring Harbour Asia meeting in Suzhou(China), 3-7 Nov, 2014.

WEN S., Tan Z., Hui C.C. and Cheah K.S.E., Poster Presentation Award "Functional Roles for Irx3 and Irx5 in Skeletal Development", 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

YAO Q., Chan W.C.W., Ng V.C.W., Tan Z., Tsang K.Y., Cheah K.S.E. and Chan D., Hypertrophic Chondrocytes under ER Stress Utilizes the Hypoxia Stress Signals for Survival, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

YIP K.H.R., Au Y.K., Yang W., Cheung M.C.H., Chan D. and Cheah K.S.E., Towards Understanding Genetic and Molecular Etiology of Campomelic Dysplasia., 19th Research Postgraduate Symposium Hong Kong Dec 10-11, 2014.. 2014.

YIP K.H.R., Au Y.K., Yang W., Cheung M.C.H., Chan D. and Cheah K.S.E., Towards Understanding Genetic and Molecular Etiology of Campomelic Dysplasia, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

Yang L., Tsang K.Y., Tang H.C., Chan D. and Cheah K.S.E., Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation, Proc Nat Acad Sci. 2014, published ahead of print: doi:10.1073/pnas.1302703111.

Yang L., Tsang K.Y., Tang H.C., Chan D. and Cheah K.S.E., Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation, Proc Natl Acad Sci U S A. 2014, 111(33): 12097-102.

ZHANG Y., Song Y., Samartzis D., Bow C., Cheah K.S.E., Cheung M.C.H., Sham P.C., Chan D. and Leung K.K.H., Genetic risks for chronic periodontitis: preliminary data of a genome-wide association study., International Association for Dental Research Pan European Region Congress. Dubrovnik, Croatia. September 10-13, 2014.. 2014.

Zheng Y., Song Y., Samartzis D., Bow H.Y.C., Cheah K.S.E., Cheung K.M.C., Sham P.C., Chan D. and Leung W.K., Genetic risks for chronic periodontitis: preliminary data of a genome-wide association study, International Association for Dental Research Pan European Region Congress. Dubrovnik, Croatia, 2014.

Researcher : Cheng LYL

Project Title:	A concordance study of the importance of autosomal short tandem repeat (STR) and Y-chromosome STR in the Chinese community
Investigator(s):	Cheng LYL, Tan-Un KC
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Researcher : Cheng Y

List of Research Outputs

Researcher : Cheung HYZ

List of Research Outputs

ZHOU P., O W., Yang X. and Cheung H.Y.Z., Potential Role of Atg16L1 in Autophagic Vesicle Trafficking in Primary Cultured Neurons, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Researcher : Cheung MCH

Project Title:	In vivo Functional Analysis of Posttranslational Modifications of Sox9 in Neural Crest Development
Investigator(s):	Cheung MCH, Zhou G
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2010

Project Title:	Investigating the roles of SOX9 in human neural stem cells
Investigator(s):	Cheung MCH
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

Project Title:	2014 International SOX Research Conference; Sox9 and the molecular network regulating neural crest cell motility
Investigator(s):	Cheung MCH
Department:	Anatomy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2014
Completion Date:	09/2014

Project Title:	In vivo functional characterization of a Rho GTPase-activating protein, DLC1, in neural crest development
Investigator(s):	Cheung MCH
Department:	Anatomy
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	10/2014

Project Title:	Single-cell transcriptomics in Sertoli cells and neural crest cells
Investigator(s):	Cheung MCH
Department:	Anatomy
Source(s) of Funding:	SFC / RGC Joint Research Scheme
Start Date:	01/2015

Project Title:	Elucidating the contribution of cross-regulatory interactions between SOX9 and SOX10 to melanoma progression
Investigator(s):	Cheung MCH, Lung HL
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	03/2015

List of Research Outputs

YIP K.H.R., Au Y.K., Yang W., Cheung M.C.H., Chan D. and Cheah K.S.E., Towards Understanding Genetic and Molecular Etiology of Campomelic Dysplasia., 19th Research Postgraduate Symposium Hong Kong Dec 10-11, 2014.. 2014.

ZHANG Y., Song Y., Samartzis D., Bow C., Cheah K.S.E., Cheung M.C.H., Sham P.C., Chan D. and Leung K.K.H., Genetic risks for chronic periodontitis: preliminary data of a genome-wide association study., International Association for Dental Research Pan European Region Congress. Dubrovnik, Croatia. September 10-13, 2014.. 2014.

Researcher : Cheung YW

List of Research Outputs

DIRKZWAGER R.M., Cheung Y.W., Richards J.S. and Tanner J.A., Diagnosing malaria using DNA aptamers against P. falciparum LDH., Point of Care Diagnostics World Congress, San Diego, USA (2014). 2014.

Researcher : DIRKZWAGER RM

List of Research Outputs

FRASER L.A., DIRKZWAGER R.M., LIANG S. and Tanner J.A., Towards a Universal Aptamer Diagnostics Platform, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

TANG S.L.M., Godonoga M., DIRKZWAGER R.M., KINGHORN A.B., Heddle J. and Tanner J.A., DNA Origami Integrated to Aptamer-mediated Molecular Recognition, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Researcher : Deng J

List of Research Outputs

CHENG Y., Tang H.M.V., GAO W., Deng J., Chan C.P. and Jin D., Ubiquitination and Proteosomedependent Degradation of the Activated Form of Human Liver-enriched Transcription Factor CREB- H, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

Tang H.M.V., Gao W., Chan C.P., Cheng Y., Chaudhary V., Deng J., Yuen K.S., Wong C.M., Ng I.O.L., Kok K.H., Zhou J. and Jin D., Requirement of CRTC1 coactivator for hepatitis B virus transcription, Nucleic Acids Res. 2014, 42(20): 12455-68.

Researcher : FENG C

List of Research Outputs

LAM Y., Feng C., Chan W.C.W., Chan B.P. and Chan D., Understanding the Contribution of Lgr5+ Interzone Progenitor Cells in Joint Repair, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

LAM Y., FENG C., Chan W.C.W., Cheah K.S.E., Chan B.P. and Chan D., Understanding the contribution of Lgr5+ interzone progenitor cells in articular cartilage regeneration., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.

Researcher : FRASER LA

List of Research Outputs

FRASER L.A., DIRKZWAGER R.M., LIANG S. and Tanner J.A., Towards a Universal Aptamer Diagnostics Platform, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

Researcher : FUNG SY

List of Research Outputs

FUNG S.Y., Chan C.P. and Jin D., Antiviral Activity of cGAMP against RNA Virus Infection, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

Researcher : Fan Y

List of Research Outputs

Ko J.M.Y., Zhang P., Law S.Y.K., Fan Y., Song Y., Zhao X.K., Wong H.W.E., Tang S., Song X., Lung M.L. and Wang L.D., Identity-by-descent approaches identify regions of importance for genetic susceptibility to hereditary esophageal squamous cell carcinoma, Oncology Reports. 2014, 32(2): 860-870.

Researcher : Feng C

List of Research Outputs

Researcher : Fu C

Project Title:	Systematic investigation of the roles of mitotic kinesins in spindle dynamics
Investigator(s):	Fu C
Department:	Biochemistry
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2013

Project Title:	Roles of a novel spindle pole body protein psr1p in bipolar spindle assembly and kinetochore clustering
Investigator(s):	Fu C
Department:	Biochemistry
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	12/2013

Project Title:	The role of kinesin-8 in anaphase B spindle elongation
Investigator(s):	Fu C
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2014
Completion Date:	05/2015

Project Title:	The 2014 American Society for Cell Biology (ASCB)/International Federation for Cell Biology (IFCB) Meeting; Csi1p recruits alp7p/TACC to the spindle pole bodies for bipolar spindle formation
Investigator(s):	Fu C
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	12/2014
Completion Date:	12/2014

Project Title:	The role of Cdk1 mediated phosphorylation of the CENP-A chaperone Scm3p in mitosis
Investigator(s):	Fu C
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2015

List of Research Outputs

Costa J., Fu C., Khare V. and TRAN P., csi2p modulates microtubule dynamics and organizes the bipolar spindle for chromosome segregation, Molecular Biology of the Cell. 2014, 25: 3900-3908.

Fu C., Psr1p interacts with SUN/sad1p and EB1/mal3p to establish the bipolar spindle , The 3rd International Conference on Cellular Dynamics and Chemical Biology. 2014.

Fu C., The fission yeast TACC homolog alp7 is recruited to the spindle pole for bipolar spindle formation , The 4th International Conference on Cellular Dynamics and Chemical Biology. 2014.

LI T., Wang F.S., Huang J. and Fu C., Controlling Mitochondria Distribution with Chimeric Proteins, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Wang X., Yu H., Xu L., Zhu T., ZHENG F., Fu C., Wang Z. and Dou Z., Dynamic Autophosphorylation of Mps1 Kinase Is Required for Faithful Mitotic Progression, PLoS ONE. 2014, 9: e104723.

ZHENG F., LI T., Jin D., Syrovatkinac V., Scheffler K., Tran P. and Fu C., Csi1p recruits alp7p/TACC to the spindle pole bodies for bipolar spindle formation, Molecular Biology of the Cell. 2014, 25: 2750-2760.

Researcher : GAO W

List of Research Outputs

CHENG Y., Tang H.M.V., GAO W., Deng J., Chan C.P. and Jin D., Ubiquitination and Proteosomedependent Degradation of the Activated Form of Human Liver-enriched Transcription Factor CREB- H, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

LEUNG K.C., Ma C.H., Gao W., Chu W.Y., Wong W.L., Jin D., Lo I.F.M., Luk H.M. and Chung B.H.Y., Contribution of gain-of-function mutations in R1T1 to the pathogenesis of Noonan syndrome - A report of 3 new Chinese patients in Hong Kong (1st runner-up prize of best oral presentation), 50^th Anniversary Scientific Meeting, Dept of Paed & Adol Med, HKU, 29-30 November 2014.

Tang H.M.V., Gao W., Chan C.P., Cheng Y., Chaudhary V., Deng J., Yuen K.S., Wong C.M., Ng I.O.L., Kok K.H., Zhou J. and Jin D., Requirement of CRTC1 coactivator for hepatitis B virus transcription, Nucleic Acids Res. 2014, 42(20): 12455-68.

Researcher : GHOSH S

List of Research Outputs

GHOSH S. and Zhou Z., Regulation of SIRT6 Activities by the Lamins, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

Ghosh S. and Zhou Z., SIRTain regulators of premature senescence and accelerated aging., In: ZIHE RAO, Protein Cell. SPRINGER/Higher Education Press, 2015, 6: 322-333.

Researcher : Gao B

Project Title:	Characterize the in vivo functional significance of Vangl2 phosphorylation in Planar Cell Polarity (PCP)
Investigator(s):	Gao B
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2015

Project Title:	Frontiers of Cell Signaling; Planar cell polarity signaling in limb development
Investigator(s):	Gao B
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2015

Researcher : Gao W

List of Research Outputs

Researcher : Gao W

List of Research Outputs

Researcher : Ghosh S

List of Research Outputs

GHOSH S. and Zhou Z., Regulation of SIRT6 Activities by the Lamins, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

Ghosh S. and Zhou Z., SIRTain regulators of premature senescence and accelerated aging., In: ZIHE RAO, Protein Cell. SPRINGER/Higher Education Press, 2015, 6: 322-333.

Researcher : Guo S

Project Title:	47th Annual Meeting for the Japanese Society of Developmental Biologists; Lack of β1 integrin results in defective notochord morphogenesis with impaired convergent extension in the mouse
Investigator(s):	Guo S
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2014

Researcher : HO TH

List of Research Outputs

Yuen K.S., Chan C.P., Wong N.H.M., HO C.H., HO T.H., Lei T., Deng W., Tsao G.S.W., Chen H., Kok K.H. and Jin D., CRISPR/Cas9-mediated genome editing of Epstein-Barr virus in human cells, Journal of General Virology. 2015, 96: 626-636.

Researcher : HOR HH

List of Research Outputs

HOR H.H., The functions of Suppressor of fused (Sufu) in midbrain and hindbrain, PhD Thesis, The University of Hong Kong. 2014.

Researcher : HU J

List of Research Outputs

HU J., Bitter P., Jonas F., Sham M.H., Huang J., Lenz P. and Huang W., Quantitative Characterization of Mesenchymal Cell Aggregation Process, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

Researcher : HU X

List of Research Outputs

HU X., The Role of Uhrf1 in Development and Tumorigenesis, PhD Thesis, The University of Hong Kong. 2014.

YANG X., Hu X. and Zhou Z., Novel Post Transcriptional Modification of UHRF1 and Its Biological Relevance, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Researcher : HUA Y

List of Research Outputs

Zhang B., HUA Y., Yu B., Lau C.Y., Cai J., Zheng S.Y., Yam W.C., Kao R.Y.T., Sze K.H., Zheng B., Yuen K.Y. and Huang J., Recombinant ESAT-6-Like Proteins Provoke Protective Immune Responses against Invasive Staphylococcus aureus Disease in a Murine Model, Infection and Immunity. 2015, 83: 339-345.

Researcher : Ho JWY

List of Research Outputs

Ho J.W.Y., Knutzen K.B., Wong N.S., Chan L.K. and Sham M.H., AMEE 2014 Excellence in Education – the 21st Century Teacher, Milan, Italy, 30th Aug - 3rd Sept 2014.

Ho J.W.Y., Knutzen K.B., Wong N.S., Chan L.K. and Sham M.H., Virtually there: A journey to the HKU Medicine Island for teaching and learning, Association for Medical Education in Europe (AMEE), 30 August – 3 September 2014, Milan, Italy. 2014.

Ho J.W.Y., Wong N.S., YE L., Chan L.K. and Sham M.H., ePoster Award (Second runner up), Title: Virtually there: a journey to the HKU Medicine Island for teachnig and learning, HKU Li Ka Shing Faculty of Medicine Frontiers Series – East-West Alliance Global Symposia. 2014.

Researcher : Hu X

List of Research Outputs

HU X., The Role of Uhrf1 in Development and Tumorigenesis, PhD Thesis, The University of Hong Kong. 2014.

Researcher : Huang J

Project Title:	RNA-DNA hybrid oligonucleotide mediated site-specific repair and gene therapy
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Matching Fund for Hi-Tech Research and Development Program of China (863 Projects)
Start Date:	01/2003

Project Title:	Development of a Pan-organism Riboregulator Device
Investigator(s):	Huang J, Jin Y
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	11/2009

Project Title:	Development of a Pan-organism Riboregulator Device
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	12/2009

Project Title:	Role of kinesin-1 in NMDAR trafficking and cerebral ischemia
Investigator(s):	Huang J, Lin R
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2012

Project Title:	Guiding the immune response: a novel approach for HIV-1 vaccine development
Investigator(s):	Huang J, Zhang M
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	Outstanding Research Student Supervisor Award 2011-12
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	01/2013

Project Title:	Protein Trafficking: Mechanism and Diseases
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	04/2013

Project Title:	Non-canonical role of Kif5b in clathrin uncoating and the endocytic regulation of muscarinic acetylcholine receptors
Investigator(s):	Huang J, Ni Y
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2013

Project Title:	A Generic Mechanism for Pattern Formation: From Theoretical Physics To Synthetic Biology
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	France/Hong Kong Joint Research Scheme - Travel Grants
Start Date:	01/2014

Project Title:	Regulation of epithelial cell proliferation by mechanical force
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

Project Title:	18th European Bioenergetics Conference; Molecular Motor Protein Kinesin-1 Controls The Localization Of Mitochondria And Myofibrils Components
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2014
Completion Date:	07/2014

Project Title:	In vivo delivery and expression of shRNA targeting SKI and SI9 by Salmonella to tumours
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	SFC / RGC Joint Research Scheme
Start Date:	01/2015

Project Title:	Pattern formation by bacteria: from theoretical physics to synthetic biology
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	ANR / RGC Joint Research Scheme
Start Date:	01/2015

Project Title:	A feasibility study on the inhibition of Staphylococcus aureus infection using AdsA specific antibodies
Investigator(s):	Huang J, Chen Z
Department:	Biochemistry
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	Biochemical and biophysical characterization of Kif5b cargo binding domain
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2015

Project Title:	Development of antibodies against Staphylococcus aureus infection
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2015

List of Research Outputs

HU J., Bitter P., Jonas F., Sham M.H., Huang J., Lenz P. and Huang W., Quantitative Characterization of Mesenchymal Cell Aggregation Process, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

Huang J., Synthetic Patterns: Sequential Establishment of Stripe Patterns in an Expanding Cell Population, Saarland University, Saarbrücken, Germany. 2014.

Huang J., Synthetic Patterns: Sequential Establishment of Stripe Patterns in an Expanding Cell Population, The Center for Research and Interdisciplinarity (CRI), the University Paris Descartes, 24, rue du Faubourg Saint Jacques, 75014 Paris, France. 2014.

Huang J., Synthetic Patterns: Sequential Establishment of Stripe Patterns in an Expanding Cell Population, Université Paris Diderot - Paris 7, Paris, France. 2014.

LEUNG H.C., Chan C.S., Poon K.M., ZHAO H., Cheung C.Y., Ng F., Huang J. and Zheng B., An H5N1-based matrix protein 2 ectodomain tetrameric peptide vaccine provides cross-protection against lethal infection with H7N9 influenza virus, Emerging Microbes & Infections. 2015, 4: e22.

LI T., Wang F.S., Huang J. and Fu C., Controlling Mitochondria Distribution with Chimeric Proteins, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

LIN Q., XU C., Lee M., Yu B. and Huang J., Exploring the Mechanisms of Salmonella-induced Reduction of Cancer Metastasis, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

LIU L. and Huang J., Analysis of Mammalian Gene Expression Noise in a Negative-feedback Loop, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

LU S. and Huang J., Generation of Early HIV-1 Specific Intermediated B Cell Line Based on Improved B Cells Immortalization Followed with Magnetic Isolation from PBMC of a Health Donor, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

TANG X., Huang J. and Guan X., ASCL1 is Essential in Maintaining CD133+ Cancer Stem Cells in HCC, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

TANG Y.H., Chen Q., Liu L., Huang J. and Shum H.C., Droplet Microfluidics for Single Cell Sorting Based on Fluorescent Protein Expression, The 6th International Symposium on Microchemistry and Microsystems, Singapore. 2014.

WU H., ZHANG X., Zhang H.J., Zhang Q., Chen Z., Huang J., Lee S.S. and Zheng B., In Vitro Selection of HIV-1 CRF08_BC Variants Resistant to Reverse Transcriptase Inhibitors , AIDS Research and Human Retroviruses. 2015, 31: 260-270.

Researcher : Huang J.

Project Title:	RNA-DNA hybrid oligonucleotide mediated site-specific repair and gene therapy
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Matching Fund for Hi-Tech Research and Development Program of China (863 Projects)
Start Date:	01/2003

Project Title:	Development of a Pan-organism Riboregulator Device
Investigator(s):	Huang J, Jin Y
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	11/2009

Project Title:	Development of a Pan-organism Riboregulator Device
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	12/2009

Project Title:	Role of kinesin-1 in NMDAR trafficking and cerebral ischemia
Investigator(s):	Huang J, Lin R
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2012

Project Title:	Guiding the immune response: a novel approach for HIV-1 vaccine development
Investigator(s):	Huang J, Zhang M
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	Outstanding Research Student Supervisor Award 2011-12
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	01/2013

Project Title:	Protein Trafficking: Mechanism and Diseases
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	04/2013

Project Title:	Non-canonical role of Kif5b in clathrin uncoating and the endocytic regulation of muscarinic acetylcholine receptors
Investigator(s):	Huang J, Ni Y
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2013

Project Title:	A Generic Mechanism for Pattern Formation: From Theoretical Physics To Synthetic Biology
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	France/Hong Kong Joint Research Scheme - Travel Grants
Start Date:	01/2014

Project Title:	Regulation of epithelial cell proliferation by mechanical force
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

Project Title:	18th European Bioenergetics Conference; Molecular Motor Protein Kinesin-1 Controls The Localization Of Mitochondria And Myofibrils Components
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2014
Completion Date:	07/2014

Project Title:	In vivo delivery and expression of shRNA targeting SKI and SI9 by Salmonella to tumours
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	SFC / RGC Joint Research Scheme
Start Date:	01/2015

Project Title:	Pattern formation by bacteria: from theoretical physics to synthetic biology
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	ANR / RGC Joint Research Scheme
Start Date:	01/2015

Project Title:	A feasibility study on the inhibition of Staphylococcus aureus infection using AdsA specific antibodies
Investigator(s):	Huang J, Chen Z
Department:	Biochemistry
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	Biochemical and biophysical characterization of Kif5b cargo binding domain
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2015

Project Title:	Development of antibodies against Staphylococcus aureus infection
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2015

List of Research Outputs

Researcher : Huang W

List of Research Outputs

HU J., Bitter P., Jonas F., Sham M.H., Huang J., Lenz P. and Huang W., Quantitative Characterization of Mesenchymal Cell Aggregation Process, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

Researcher : Hui CC

List of Research Outputs

WEN S., Tan Z., Hui C.C. and Cheah K.S.E., Functional Roles for Irx3 and Irx5 in Skeletal Development, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

WEN S., Tan Z., Hui C.C. and Cheah K.S.E., Functional roles for Irx3 and Irx5 in osteoblast differentiation, Cold Spring Harbour Asia meeting in Suzhou(China), 3-7 Nov, 2014.

WEN S., Tan Z., Hui C.C. and Cheah K.S.E., Poster Presentation Award "Functional Roles for Irx3 and Irx5 in Skeletal Development", 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Researcher : Jin D

Project Title:	Mitotic checkpoint and genomic stability in ovarian cancer
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	National Institutes of Health, US Department of Health and Human Services - General Award
Start Date:	09/2002

Project Title:	Roles for p21-activated protein kinase 3 in HTLV-I pathogenesis
Investigator(s):	Jin D, Ching YP
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2006

Project Title:	Outstanding Researcher Award 2007-2008
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	10/2008

Project Title:	4th Intracellular Proteolysis Meeting on Ubiquitin-proteasome System, Dynamics and Targeting REV7-mediated polyubiquitination and degradation of human REV1
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2009

Project Title:	Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy
Investigator(s):	Jin D, Kok KH, Lei T
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	01/2010

Project Title:	Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	01/2010

Project Title:	Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	01/2010

Project Title:	Mapping of peptide sequence in swine-origin H1N1 influenza virus hemagglutinin associated with the induction of anti-ganglioside antibodies implicated in Guillain-Barre syndrome: a pilot study
Investigator(s):	Jin D, Zheng B
Department:	Biochemistry
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2011

Project Title:	Molecular mechanisms of innate antiviral response
Investigator(s):	Jin D, Kok KH, Lau ASY, Sham MH, Yuen KY, Zheng B
Department:	Biochemistry
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2012

Project Title:	Roles of LKB1 tumor suppressor in human T-cell leukemia virus type I transcription and leukemogenesis
Investigator(s):	Jin D, Tang HMV
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2012

Project Title:	Molecular dissection of NSs virulence factor in severe fever with thrombocytopenia syndrome virus (SFTSV), a novel bunyavirus identified in China
Investigator(s):	Jin D, Kok KH
Department:	Biochemistry
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2013

Project Title:	Roles of Epstein-Barr virus-encoded miR-BART microRNAs in viral persistence and transformation of epithelial cells
Investigator(s):	Jin D, Huang J, Tang HMV
Department:	Biochemistry
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2013

Project Title:	Roles of CRTC coactivators in hepatitis B virus X protein-mediated activation of CREB-dependent transcription
Investigator(s):	Jin D, Zheng B, Zhou J, Tang HMV
Department:	Biochemistry
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2013

Project Title:	Anti-hepatitis B virus activity of Resveratrol and mechanism of action
Investigator(s):	Jin D, Zhou J
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013
Completion Date:	04/2015

Project Title:	Molecular Mechanisms of Innate Immunity
Investigator(s):	Jin D, Lu L, Lau ASY, Tu W
Department:	Biochemistry
Source(s) of Funding:	Croucher Foundation - Conference / Seminars
Start Date:	06/2013

Project Title:	Roles of SIRT1 deacetylase in human T-cell leukemia virus type I transcription and leukemogenesis
Investigator(s):	Jin D, Ching YP, Tu W
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Regulatory roles of SIRT1 deacetylase in hepatitis B virus transcription
Investigator(s):	Jin D, Zhou J, Tang HMV
Department:	Biochemistry
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2014

Project Title:	Mechanism of inflammasome activation by SARS coronavirus 3a protein
Investigator(s):	Jin D, Zheng B, Tang HMV
Department:	Biochemistry
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2014

Project Title:	Immunostimulatory RNA in live attenuated measles vaccine
Investigator(s):	Jin D, Kok KH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2014
Completion Date:	05/2015

Project Title:	Characterization of a novel cGAMP-hydrolyzing phosphodiesterase encoded by Middle East respiratory syndrome coronavirus
Investigator(s):	Jin D, Tse H
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

Project Title:	16th International Symposium on EBV and Assocaited Diseases; Roles of Epstein-Barr virus-encoded BART microRNAs in viral persistence and nasopharyngeal carcinogenesis
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2014
Completion Date:	07/2014

Project Title:	Outstanding Research Student Supervisor Award 2013-14
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	12/2014

Project Title:	Identification and characterization of human cyclic dinucleotide phosphodiesterases that hydrolyze cGAMP second messenger
Investigator(s):	Jin D, Tse H
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Novel regulatory mechanisms in RIG-I-dependent innate antiviral response
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	Croucher Senior Research Fellowships in Natural Sciences, Technology and Medicine
Start Date:	01/2015

Project Title:	Characterization of a novel β-TrCP-dependent pathway for ubiquitination and degradation of liver-enriched transcription factor CREB-H
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2015

List of Research Outputs

CHENG Y., Tang H.M.V., GAO W., Deng J., Chan C.P. and Jin D., Ubiquitination and Proteosomedependent Degradation of the Activated Form of Human Liver-enriched Transcription Factor CREB- H, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

FUNG S.Y., Chan C.P. and Jin D., Antiviral Activity of cGAMP against RNA Virus Infection, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

Jin D., The CRISPR/Cas9-mediated genome editing of Epstein-Barr virus: a new platform for genetic study, International Forum for Herpesvirus, Associated Diseases and Antiviral Development. 2014.

Jin D., Viral suppression of innate antiviral response through PACT targeting, The 1st National Symposium on Virology for Young Scholars. 2014.

LEUNG K.C., Ma C.H., Gao W., Chu W.Y., Wong W.L., Jin D., Lo I.F.M., Luk H.M. and Chung B.H.Y., Contribution of gain-of-function mutations in R1T1 to the pathogenesis of Noonan syndrome - A report of 3 new Chinese patients in Hong Kong (1st runner-up prize of best oral presentation), 50^th Anniversary Scientific Meeting, Dept of Paed & Adol Med, HKU, 29-30 November 2014.

Plani-Lam J.H., Chow T.C., Siu K.L., Chau W.H., Ng M.H., Bao S., Ng C.T., Sham P.C., Shum D.K.Y., Jin D. and Song Y., PTPN21 exerts pro-neuronal survival and neuritic elongation via ErbB4/NRG3 signaling, The International Journal of Biochemistry & Cell Biology. Int J Biochem Cell Biol, 2015, 61: 53-62.

Tang H.M., Pan K., Kong K.Y.E., Hu L., Chan L.C., Siu K.L., Sun H., Wong C.M. and Jin D., Loss of APD1 in Yeast Confers Hydroxyurea Sensitivity Suppressed by Yap1p Transcription Factor, Scientific Reports. 2015, 5: 7897.

Tang H.M.V., Gao W., Chan C.P., Cheng Y., Chaudhary V., Deng J., Yuen K.S., Wong C.M., Ng I.O.L., Kok K.H., Zhou J. and Jin D., Requirement of CRTC1 coactivator for hepatitis B virus transcription, Nucleic Acids Res. 2014, 42(20): 12455-68.

WANG P., Siu K.L., Zhang Y., Yang W., Kok K.H. and Jin D., IFI16β and STINGβ: Negative Regulators of Innate Immunity Generated by Alternative Splicing, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

Yuen K.S., Chan C.P., Wong N.H.M., HO C.H., HO T.H., Lei T., Deng W., Tsao G.S.W., Chen H., Kok K.H. and Jin D., CRISPR/Cas9-mediated genome editing of Epstein-Barr virus in human cells, Journal of General Virology. 2015, 96: 626-636.

Yuen K.S., Lei T., Kok K.H. and Jin D., Role of Epstein-Barr virus-encoded BART microRNAs in viral infection and transformation of nasopharyngeal epithelial cells, The Croucher Foundation Advanced Study Institute on “Advances in Nasopharyngeal Carcinoma Studies”.. 2014.

ZHANG X., WU H., Zhang Q., Lau T.C.K., Chu H., Chen Z., Jin D. and Zheng B., A novel mutation, D404N, in the connection subdomain of reverse transcriptase of HIV-1 CRF08_BC subtype confers cross-resistance to NNRTIs, Journal of Antimicrobial Chemotherapy. 2015.

ZHENG F., LI T., Jin D., Syrovatkinac V., Scheffler K., Tran P. and Fu C., Csi1p recruits alp7p/TACC to the spindle pole bodies for bipolar spindle formation, Molecular Biology of the Cell. 2014, 25: 2750-2760.

Researcher : KEW C

List of Research Outputs

Chan C.P., YUEN C.K., FUNG S.Y., KEW C., Zheng B., Yuen K.Y. and Jin D., Influenza A virus NS1 protein targets double-stranded RNA binding protein PACT to suppress innate antiviral response, Innate Immune Memory: A Wellcome Trust Scientific Conference. 2015.

KEW C., Inhibition of PACT mediated type I interferon production by herpes simplex virus type 1 Us11 protein, M Phil Thesis, The University of Hong Kong. 2014.

KEW C., Siu K.L., Chan C.P. and Kok K.H., Viral suppression of type I interferon production through PACT targeting, The Yin & Yang of the Interferon System. International Cytokine and Interferon Society Satellite Symposium. 2014.

Researcher : KHONG ML

List of Research Outputs

KHONG M.L., Li L., Szeto S.C., Watt R.M. and Tanner J.A., Cloning, Expression, Purification and Characterisation of Escherichia coli Polyphosphate Binding Domain as a New Tool to Understanding Polyphosphate Synthesis and Function, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Researcher : KINGHORN AB

List of Research Outputs

Dirkzwager R.D., Kinghorn A.B., Richards J.S. and Tanner J.A., APTEC: aptamer-tethered enzyme capture as a novel rapid diagnostic test for malaria, Chem. Commun.. 2015, 51: 4697-4700.

TANG S.L.M., Godonoga M., DIRKZWAGER R.M., KINGHORN A.B., Heddle J. and Tanner J.A., DNA Origami Integrated to Aptamer-mediated Molecular Recognition, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Researcher : KWAN PY

List of Research Outputs

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Regulatory role of perineuronal nets and semaphorin3A in the developmental maturation of the central vestibular circuitry, Abstracts of 9^th FENS Forum of Neuroscience, 2454. 2014.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., The involvement of perineuronal semaphorin 3A and chondroitin sulfates in regulating maturation of the central vestibular circuitry, Abstracts of 10th Int’l Symp. on Healthy Aging: 79. 2015.

Kwan P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., The involvement of perineuronal semaphoring 3A and chondroitin sulfates in regulating maturation of the central vestibular circuitry, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 79. 2015.

Researcher : KWOK CTD

List of Research Outputs

KWOK C.T.D., Expression and Functions of FOXM1 in Human Embryonic Stem Cells, M Phil Thesis, The University of Hong Kong. 2015.

Researcher : Kao PYP

List of Research Outputs

Cheung J.P.Y., Samartzis D., Kao P.Y.P., Shigematsu H., Cheah K.S.E., Song Y., Sham P.C., Chan D. and Cheung K.M.C., Developmental lumbar spinal stenosis in Southern Chinese: findings from a genome-wide association study, Combined Academic Conference of the 18th Biennial Congress of the Asia Pacific Orthopaedic Association and the 36th Annual Meeting of the Royal College of Orthopaedic Surgeons of Thailand. Pattaya, Thailand, 2014.

Li Y., Kao P.Y.P., Yip M.S., Sze K.L., Fosang A., McCulloch D., Cheung K.M.C., Samartzis D., Luk K.D.K., Karppinen J.I., Song Y., Cheah K.S.E., Sham P.C. and Chan D., Association and functional analysis of ADAMTS5 in lumbar disc degeneration, 42nd International Society for the Study of the Lumbar Spine. San Francisco, 2015.

Researcher : Kok KH

Project Title:	Identification of a novel splice isoform of TRBP and characterization of its role in microRNA biogenesis
Investigator(s):	Kok KH, Wong CM
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012

Project Title:	Mechanistic study of the roles of PACT in MDA5-mediated innate antiviral immunity
Investigator(s):	Kok KH, Chan CP
Department:	Biochemistry
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2013

Project Title:	Role of PACT in host antiviral defence against influenza A virus
Investigator(s):	Kok KH
Department:	Biochemistry
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2013

Project Title:	Roles of PACT in the induction of type I interferon by measles virus defective interring RNA
Investigator(s):	Kok KH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2013

Project Title:	Characterization of an alternatively spliced tumor suppressor FAT1 in hepatocellular carcinoma
Investigator(s):	Kok KH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2014

Project Title:	The 16th International Symposium on EBV and Associated Diseases; Modulation of innate antiviral response by a single Epstein-Barr virus-encoded microRNA
Investigator(s):	Kok KH
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2014
Completion Date:	07/2014

Project Title:	Suppression of PACT-dependent antiviral response by measles virus V protein
Investigator(s):	Kok KH
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2015

List of Research Outputs

WANG P., Siu K.L., Zhang Y., Yang W., Kok K.H. and Jin D., IFI16β and STINGβ: Negative Regulators of Innate Immunity Generated by Alternative Splicing, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

Researcher : Kudelko MA

Project Title:	Computational Mass Spectrometry-Based Proteomics; Chondrocyte Cells at the banks of the River Styx
Investigator(s):	Kudelko MA
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2014
Completion Date:	07/2014

List of Research Outputs

Li M., Grandadam M., Kwok K.T.H., Lagache T., Siu Y.L., Zhang J., Sayteng K., Kudelko M.A., Qin C.F., Olivo-Marin J.C., Bruzzone R. and Wang P., KDEL receptors assist dengue virus exit from the endoplasmic reticulum, Cell Reports. 2015, 10(9): 1496–1507.

Researcher : Kwan PY

List of Research Outputs

Researcher : Kwok LF

List of Research Outputs

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilization of chondroitinase ABC-I and –II on chitosan microbeads improve neurite growth in CSPG-enriched astrocyte culture, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 64. 2015.

Researcher : LAM CF

List of Research Outputs

LAM C.F. and Ng R.K., Deregulation of Cybb Prevents Myeloid Differentiation in Mll-Een Leukemia Cell, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

Researcher : LAM Y

List of Research Outputs

LAM Y., Feng C., Chan W.C.W., Chan B.P. and Chan D., Understanding the Contribution of Lgr5+ Interzone Progenitor Cells in Joint Repair, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

Researcher : LAU WY

List of Research Outputs

LAU W.Y., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Characterization of Heparanase 1 and Heparanase 2 at Hippocampus, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

LAU W.Y., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Role of heparanase 1 and heparanase 2 in modulating synaptic activities, Abstracts of 10th Int’l Symp. on Healthy Aging: 77. 2015.

Researcher : LEE KS

List of Research Outputs

LEE K.S., In vivo study of Asporin function in cartilage tissues, PhD Thesis, The University of Hong Kong. 2014.

Researcher : LEUNG HY

List of Research Outputs

Shum D.K.Y., TAI W.Y.E., Shea G.H.K., Tsui Y.P., LEUNG H.Y. and Chan Y.S., Juxtacrine signalling via Notch and ErbB receptors in the switch to fate commitment of bone marrow-derived Schwann cells, Soc. Neuroscience Abstract (USA) 589.10/A21. 2014.

Tai W.Y.E., Shea G.K.H., Leung H.Y., Tsui Y.P., Chan Y.S. and Shum D.K.Y., INSTRUCTIVE ROLE OF DRG NEURONS IN DERIVATION OF SCHWANN CELLS FROM BONE MARROW STROMAL CELLS, Tenth International Symposium on Healthy Aging “A Decade of Positive Aging”. 2015.

Researcher : LEUNG MH

List of Research Outputs

LEUNG M.H., Investigating the Role of the Forkhead box Transcription Factor FOXM1 against Oxidative Stress and DNA Damage in Human Embryonic Stem Cells, M Phil Thesis, The University of Hong Kong. 2015.

Researcher : LI J

List of Research Outputs

LI J. and Wang J.J., Current trend of annotating single nucleotide variation in humans – A case study on SNVrap, Methods. 2015, 79-80: 32-40.

LI J., Sham P.C., Song Y. and Li M.X., SPS: A Simulation Tool for Calculating Power of Set-based Genetic Association Tests, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

LI J., Deng S.J., WANG P., Yang W., Ho S.L., Sham P.C., Wang J.J. and Li M., wKGGSeq: A Comprehensive Strategy-Based and Disease-Targeted Online Framework to Facilitate Exome Sequencing Studies of Inherited Disorders, Human Mutation. 2015, 36: 496-503.

Nelson M.R., Tipney H., Painter J.L., Shen J., Nicoletti P., Shen Y., Floratos A., Sham P.C., LI J., Wang J.J., Cardon L.R., Whittaker J.C. and Sanseau P., The support of human genetic evidence for approved drug indications, Nature Genetics. 2015.

WANG P., Qin J., QIN Y., ZHU Y., WANG Y., LI J., Zhang M.Q. and Wang J.J., ChIP-Array 2: integrating multiple omics data to construct gene regulatory networks, Nucleic Acids Research. 2015, 43(W1): W264-9.

Researcher : LI J

List of Research Outputs

LI J. and Wang J.J., Current trend of annotating single nucleotide variation in humans – A case study on SNVrap, Methods. 2015, 79-80: 32-40.

Researcher : LI T

List of Research Outputs

LI T., Wang F.S., Huang J. and Fu C., Controlling Mitochondria Distribution with Chimeric Proteins, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

ZHENG F., LI T., Jin D., Syrovatkinac V., Scheffler K., Tran P. and Fu C., Csi1p recruits alp7p/TACC to the spindle pole bodies for bipolar spindle formation, Molecular Biology of the Cell. 2014, 25: 2750-2760.

Researcher : LIANG S

List of Research Outputs

FRASER L.A., DIRKZWAGER R.M., LIANG S. and Tanner J.A., Towards a Universal Aptamer Diagnostics Platform, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

LIANG S., Dhillo W.S., Cass A.E. and Tanner J.A., Development of an Aptamer-based Biosensing System for Measuring Luteinizing Hormone Pulsatility for Infertility Treatment, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Researcher : LIN Q

List of Research Outputs

LIN Q., XU C., Lee M., Yu B. and Huang J., Exploring the Mechanisms of Salmonella-induced Reduction of Cancer Metastasis, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

Researcher : LIU L

List of Research Outputs

LIU L. and Huang J., Analysis of Mammalian Gene Expression Noise in a Negative-feedback Loop, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

TANG Y.H., Chen Q., Liu L., Huang J. and Shum H.C., Droplet Microfluidics for Single Cell Sorting Based on Fluorescent Protein Expression, The 6th International Symposium on Microchemistry and Microsystems, Singapore. 2014.

Researcher : LU S

List of Research Outputs

LU S. and Huang J., Generation of Early HIV-1 Specific Intermediated B Cell Line Based on Improved B Cells Immortalization Followed with Magnetic Isolation from PBMC of a Health Donor, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Researcher : Lam VMS

Project Title:	18th International Congress of Biochemistry and Molecular Biology Beyond the Human Glucose-6-phosphate Dehydrogenase (G6PD) Gene: Protein Structure and Function Analyses
Investigator(s):	Lam VMS
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2000

Project Title:	HUGO's Seventh International Human Genome Meeting, HGM2002 Post-Genomic Glucose-6-phosphate Dehydrogenase (G6PD): Different Mechanisms for Enzyme Deficiency from Structural and Kinetic Analyses
Investigator(s):	Lam VMS
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2002

Project Title:	7th International Symposium on Mutations in the Human Genome Multiplex Detection: a Rapid and Reliable Method to Screen Common Variations in the Glucose-6-phosphate Dehydrogenase Gene
Investigator(s):	Lam VMS
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2003

Researcher : Lam YM

List of Research Outputs

Lam Y.M., Chan L.C. and Ng R.K., BMI-1 negatively regulates JAK-STAT signaling in leukemia, EMBO workshop: Stem cells and Epigenetics in Cancer October 16-18, 2014, Hong Kong. 2014.

Researcher : Lee M

List of Research Outputs

LIN Q., XU C., Lee M., Yu B. and Huang J., Exploring the Mechanisms of Salmonella-induced Reduction of Cancer Metastasis, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

Researcher : Lei T

Project Title:	A→I editing of Epstein-Barr virus-encoded BART microRNAs and its impact on microRNA biogenesis
Investigator(s):	Lei T, Jin D
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2009

Researcher : Leung HY

List of Research Outputs

Researcher : Leung KKH

List of Research Outputs

ZHANG Y., Song Y., Samartzis D., Bow C., Cheah K.S.E., Cheung M.C.H., Sham P.C., Chan D. and Leung K.K.H., Genetic risks for chronic periodontitis: preliminary data of a genome-wide association study., International Association for Dental Research Pan European Region Congress. Dubrovnik, Croatia. September 10-13, 2014.. 2014.

Researcher : Li L

List of Research Outputs

KHONG M.L., Li L., Szeto S.C., Watt R.M. and Tanner J.A., Cloning, Expression, Purification and Characterisation of Escherichia coli Polyphosphate Binding Domain as a New Tool to Understanding Polyphosphate Synthesis and Function, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Researcher : Li M

List of Research Outputs

Wong M.K., Li M., Chan Y.S. and Shum D.K.Y., Dynamics of chondroitin sulfotransferase expression for cranial motor neuron migration in rat hindbrain development, Abstracts of 9^th FENS Forum of Neuroscience, 2470. 2014.

Researcher : Li Y

List of Research Outputs

Li Y., Samartzis D., Campbell D., Cherny S., Cheung K.M.C., Luk K.D.K., Karppinen J.I., Song Y., Cheah K.S.E., Sham P.C. and Chan D., A novel pathway associated with lumbar disc degeneration: a genome-wide association study, 42nd International Society for the Study of the Lumbar Spine. San Francisco, 2015.

Li Y., Kao P.Y.P., Yip M.S., Sze K.L., Fosang A., McCulloch D., Cheung K.M.C., Samartzis D., Luk K.D.K., Karppinen J.I., Song Y., Cheah K.S.E., Sham P.C. and Chan D., Association and functional analysis of ADAMTS5 in lumbar disc degeneration, 42nd International Society for the Study of the Lumbar Spine. San Francisco, 2015.

Researcher : Lin R

Project Title:	Towards a therapeutic peptide that disrupts kinesin-1-NMDAR complex to confer neuroprotection
Investigator(s):	Lin R, Huang J
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	01/2014
Completion Date:	12/2014

Researcher : Liu B

Project Title:	Adult stem cell decline accelerates premature ageing in Zmpste24 deficient mice
Investigator(s):	Liu B, Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	08/2008

Project Title:	Stem Cells 2009 Oxidative stress-mediated accelerated adult stem cell decline contributes to premature ageing in Zmpste24–/– mice
Investigator(s):	Liu B
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2009

Project Title:	Quantitative mass spectrometry-based screening for SIRT1 deacetylating targets
Investigator(s):	Liu B, Zhou Z, Chu IK
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2012

Project Title:	Role of Autophagy in Cellular Senescence and Laminopathy-based Premature Ageing
Investigator(s):	Liu B
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2013

Researcher : Liu L

List of Research Outputs

Researcher : Lui PY

List of Research Outputs

Chan C.P., Lui P.Y., FUNG S.Y. and Kok K.H., PACT targeting is a novel viral strategy of innate immune evasion, The 9th Chinese Society for Immunology Symposium. 2014.

Researcher : MA SKY

List of Research Outputs

MA S.K.Y., Shen Y., Ng V.C.W., An Y., Agata K., Lam Y.W. and Chan D., Phylogenetic Analysis of Planarian Collagens and Their Roles in Regeneration, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Researcher : MUNG KL

List of Research Outputs

MUNG K.L., Regulation of Glycogen Phosphorylas In Hypoxic Cancer Cells, M Phil Thesis, The University of Hong Kong. 2015.

Researcher : NG GCT

List of Research Outputs

Lam J.H., Chow T.C., Siu K.L., Chau W.H., Ng M.H., Bao S., Ng G.C.T., Sham P.C. and Shum D.K.Y., PTPN exerts pro-neuronal survival and neuritic elongation via ErbB4/NRG3 signaling, Int J Biochem Cell Biol. 2015, 61: 53-62.

NG G.C.T. and Song Y., The Role and Imaging of PAX6 in a Mouse Model of Alzheimer's Disease, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Researcher : Ng GCT

List of Research Outputs

Researcher : Ng MH

List of Research Outputs

Lam J.H., Chow T.C., Siu K.L., Chau W.H., Ng M.H., Bao S., Ng G.C.T., Sham P.C. and Shum D.K.Y., PTPN exerts pro-neuronal survival and neuritic elongation via ErbB4/NRG3 signaling, Int J Biochem Cell Biol. 2015, 61: 53-62.

Plani-Lam J.H., Chow T.C., Siu K.L., Chau W.H., Ng M.H., Bao S., Ng C.T., Sham P.C., Shum D.K.Y., Jin D. and Song Y., PTPN21 exerts pro-neuronal survival and neuritic elongation via ErbB4/NRG3 signaling, The International Journal of Biochemistry & Cell Biology. Int J Biochem Cell Biol, 2015, 61: 53-62.

Researcher : Ng RK

Project Title:	The functional role of epigenetic memory in the differentiation plasticity of induced pluripotent stem cells
Investigator(s):	Ng RK
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	Function of PRMT1 in the establishment of leukemia stem cell
Investigator(s):	Ng RK
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2013

Project Title:	The role of PRMT1 in activation of leukemia stem cell program in MLL-rearranged leukemia
Investigator(s):	Ng RK, Yiu SM, Chan LC
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Function of polycomb protein Bmi-1 in hematopoietic Wnt signaling pathway
Investigator(s):	Ng RK
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

Project Title:	International Society for Stem Cell Research ISSCR 2015 Annual Meeting; Epigenetic function of Bmi-1 in the regulation of hematopoietic stem cell self-renewal
Investigator(s):	Ng RK
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2015

Project Title:	Dysregulation of DNA methylation in MLL-rearranged leukemia
Investigator(s):	Ng RK
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2015

List of Research Outputs

LAM C.F. and Ng R.K., Deregulation of Cybb Prevents Myeloid Differentiation in Mll-Een Leukemia Cell, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

Lam Y.M., Chan L.C. and Ng R.K., BMI-1 negatively regulates JAK-STAT signaling in leukemia, EMBO workshop: Stem cells and Epigenetics in Cancer October 16-18, 2014, Hong Kong. 2014.

Lui W.C., Chan Y.F. and Ng R.K., PRMT1 activates leukemic stem cell program in MLL-rearranged leukemia, 56th ASH Annual Meeting and Exposition December 6-9, 2014, San Francisco, United States. 2014.

Researcher : Ng VCW

List of Research Outputs

MA S.K.Y., Shen Y., Ng V.C.W., An Y., Agata K., Lam Y.W. and Chan D., Phylogenetic Analysis of Planarian Collagens and Their Roles in Regeneration, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

YAO Q., Chan W.C.W., Ng V.C.W., Tan Z., Tsang K.Y., Cheah K.S.E. and Chan D., Hypertrophic Chondrocytes under ER Stress Utilizes the Hypoxia Stress Signals for Survival, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Researcher : Ni Y

Project Title:	Three-Dimensional Super-Resolution Visualization of specific non-repetitive DNA in Single Mammalian Cells
Investigator(s):	Ni Y, Huang J
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	03/2015

Researcher : Niu B

Project Title:	Whole genome identification of active core promoters, enhancers and insulators in mouse growth plate
Investigator(s):	Niu B, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	01/2010

List of Research Outputs

Cheung M.C.H., HO S.H., Hui M.N., Wu M.H., Cheung M.P.L., Ho C.K.Y., Niu B., Cheah K.S.E. and LIU A., Sox9 and the Molecular Network Regulating Neural Crest Cell Motility, 2014 International SOX Research Conference. 2014.

Researcher : Osorio Da Silva LA

Project Title:	ISM1 in respiratory system development and homeostasis in the mouse
Investigator(s):	Osorio Da Silva LA, Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	02/2014
Completion Date:	01/2015

Researcher : QIN Y

List of Research Outputs

QIN Y., YALAMANCHILI H.K., Qin J., Yan B. and Wang J.J., The Current Status and Challenges in Computational Analysis of Genomic Big Data, Big Data Research. 2015, 2: 12-18.

WANG P., Qin J., QIN Y., ZHU Y., WANG Y., LI J., Zhang M.Q. and Wang J.J., ChIP-Array 2: integrating multiple omics data to construct gene regulatory networks, Nucleic Acids Research. 2015, 43(W1): W264-9.

Researcher : Qian C

Project Title:	Structural and Mechanistic Analysis of Human SMARCAL1
Investigator(s):	Qian C, Tanner JA
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2011

Project Title:	Structural and Mechanistic Characterization of XPA-associated Complexes in Nucleotide Excision Repair Pathway
Investigator(s):	Qian C
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2012

Project Title:	Structure-Based Mechanistic Insights into Timeless-Involved Replication Fork Protection
Investigator(s):	Qian C
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2013

Project Title:	Structural analysis of Human SLX1-SLX4 Complex in DNA Repair
Investigator(s):	Qian C
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

Project Title:	Structural and Mechanistic Studies of Human SLX4 Complex in Interstrand Crosslink Repair
Investigator(s):	Qian C
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2014

List of Research Outputs

LAI Y.T., CHANG Y.Y., Hu L., YANG Y., CHAO A., Du Z., Tanner J.A., Chye M.L., Qian C., Ng K.M., Li H. and Sun H., Rapid labeling of intracellular His-tagged proteins in living cells, Proc Natl Acad Sci USA. 2015, 112: 2948-2953.

Qian C., Timeless interacts with Parp1 to promote homologous recombination repair, Gordon Research Conference on Genomic Instability/Short talk. 2014.

XIE S., LU Y., Jakoncic J., Sun H., XIA J. and Qian C., Structure of RPA32 bound to the N-terminus of SMARCAL1 redefines the binding interface between RPA32 and its interacting proteins., FEBS Journal. Europe, Wiley, 2014, 281(15): 3382-96.

XIE S., Mortuewicz O., Ma K., Poon R., Helleday T. and Qian C., Timeless interacts with Parp1 to promote homologous recombination repair, Gordon Research Conference on Genomic Instability. 2014.

Researcher : Qin J

Project Title:	Prediction of determining factors and underlying networks for cell conversion by integrating ChIP-seq/chip and transcriptome data
Investigator(s):	Qin J, Wang JJ
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	03/2015
Completion Date:	02/2016

List of Research Outputs

QIN Y., YALAMANCHILI H.K., Qin J., Yan B. and Wang J.J., The Current Status and Challenges in Computational Analysis of Genomic Big Data, Big Data Research. 2015, 2: 12-18.

WANG P., Qin J., QIN Y., ZHU Y., WANG Y., LI J., Zhang M.Q. and Wang J.J., ChIP-Array 2: integrating multiple omics data to construct gene regulatory networks, Nucleic Acids Research. 2015, 43(W1): W264-9.

Yu Y., Qin J., Chen D., Wang H., Wang J.J. and Yu Y., Chronic Cardiovascular Disease-Associated Gene Network Analysis in Human Umbilical Vein Endothelial Cells Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin, Cardiovascular Toxicology. 2014, 15 (2): 157-171.

Researcher : SHI L

List of Research Outputs

CAI C., Shi L., Liu V.W.S., TANG W.M., LIU J., Leung T.H.Y., Chan K.K.L., Yam J.W.P., Yao K.M., Ngan H.Y.S. and Chan D.W., Elevated TAK1 augments tumor growth and metastatic capacities of ovarian cancer cells through activation of NF-κB signaling , 2014.

CAI C., SHI L., Liu V.W.S., TANG W.M., LIU J., Leung T.H.Y., Chan K.K.L., Yam J.W.P., Yao K.M., Ngan H.Y.S. and Chan D.W., Elevated TAK1 augments tumor growth and metastatic capacities of ovarian cancer cells through activation of NF-κB signaling, Oncotarget. USA, Impact Journals, LLC., 2014, 5: 7549-62.

Researcher : SIT HM

List of Research Outputs

SIT H.M., Studying the role of Sox10 in enteric neural crest cell migration with Sox10NGFP Mouse mutant, M Phil Thesis, The University of Hong Kong. 2014.

Researcher : SO HF

List of Research Outputs

SO H.F. and Yao K.M., Investigating the Effects of Glucose Levels on PDZD2 Levels in Rat Insulinoma INS-1E Cells, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Researcher : Samartzis D

Project Title:	The Role of Schmorls Nodes in Lumbar Intervertebral Disc Degeneration
Investigator(s):	Samartzis D, Anthony M, Chan T, Cheung KMC, Luk KDK, Wu EX
Department:	Orthopaedics & Traumatology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2011

Project Title:	Spineweek 2012 MULTIPARAMETRIC MAGNETIC RESONANCE IMAGING OF NORMAL AND DEGENERATIVE LUMBAR INTERVERTEBRAL DISCS "CLINICAL TRIAD" MANIFESTATIONS IN THE KLIPPEL-FEIL PATIENT AND THE ASSOCIATION WITH CONGENITALLY FUSED CERVICAL SEGMENTS A LARGE-SCALE POPULATION-BASED STUDY OF MODIC CHANGES OF THE LUMBAR SPINE CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) AND T2 MAPPING IN SUBJECTS WITH INTERVERTEBRAL DISC DEGENERATION BASELINE MRI CHARACTERISTICS IN ASYMPTOMATIC SUBJECTS AS PREDICTORS FOR FUTURE FIRST-TIME LBP EPISODE
Investigator(s):	Samartzis D
Department:	Orthopaedics & Traumatology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2012

Project Title:	The Role of Ionizing Radiation Exposure in the Development of Intervertebral Disc Degeneration of the Lumbar Spine: a Prospective, Longitudinal Study
Investigator(s):	Samartzis D
Department:	Orthopaedics & Traumatology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2012

Project Title:	The Role of Adipokines in Intervertebral Disc Degeneration of the Lumbar Spine
Investigator(s):	Samartzis D, Chan D, Cheung BMY, Cheung KMC, Leung VYL, Luk KDK, Wang Y
Department:	Orthopaedics & Traumatology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2012

Project Title:	40th Annual Meeting of the International Society for the Study of the Lumbar Spine (ISSLS); SERUM METABOLOMIC BIOMARKERS AND LUMBAR DISC DEGENERATION /EPIDEMIOLOGY, DETERMINANTS, AND FUNCTIONAL STATUS OF SCIATICA: A LARGE-SCALE POPULATION-BASED STUDY IN CHINESE /THE SAFETY AND EFFICACY OF MESENCHYMAL STEM CELLS FOR PREVENTION OR REGENERATION OF INTERVERTEBRAL DISC DEGENERATION: A SYSTEMATIC REVIEW /FACET JOINT TROPISM AND DEGENERATIVE SPONDYLOLISTHESIS – A STUDY FROM THE AOSAP RESEARCH COLLABORATION
Investigator(s):	Samartzis D
Department:	Orthopaedics & Traumatology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2013

Project Title:	Metabonomics of Intervertebral Disc Degeneration
Investigator(s):	Samartzis D, Chan D, Luk KDK, Cheung KMC
Department:	Orthopaedics & Traumatology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2013

Project Title:	41st Annual Meeting of the International Society for the Study of the Lumbar Spine (ISSLS); Prediction of future first-time low back pain based on baseline MRI findings/Body Mass Index and its Association with Lumbar Disc Herniation and Sciatica: a Large-Scale, Population-Based Study/A large‐scale study of Modic changes in the lumbar spine: morphology and association with MRI phenotypes
Investigator(s):	Samartzis D
Department:	Orthopaedics & Traumatology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2014

Project Title:	Pain perception in relation to disc degeneration and low back pain
Investigator(s):	Samartzis D, Cheung KMC, Bow HYC, Cheung CW
Department:	Orthopaedics & Traumatology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2014

Project Title:	Modic Changes of the Lumbar Spine
Investigator(s):	Samartzis D, Luk KDK, Cheung KMC, Hui SK
Department:	Orthopaedics & Traumatology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2014

Project Title:	42nd Annual ISSLS Annual Meeting; UTE MRI Disc Sign (UDS): a novel imaging biomarker associated with spine degeneration, pain and disability/"Proteoglycan profile" and level-specific imaging biomarkers of lumbar disc displacement/The association of Modic changes and disabling low back pain: a large-scale, population-based study/Ciculating CCL5/RANTES: a potential biomarker for human intervertebral disc degeneration/A novel pathway associated with lumbar disc degeneration: a genome-wide association study
Investigator(s):	Samartzis D
Department:	Orthopaedics & Traumatology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2015

List of Research Outputs

Samartzis D., Editor, British Medical Journal. 2015.

Samartzis D., Editor, Spine. 2015.

Researcher : Sham MH

Project Title:	International Congress on Differentation and Cell Biology Neural-specific Cis-acting and Trans-acting Regulation of the Mouse Hoxb-3 Gene During Embryogenesis
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2000

Project Title:	Outstanding Research Student Supervisor Award 2008-2009
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	12/2009

Project Title:	Visiting Research Professors Scheme 2010-11
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	Visiting Research Professors Scheme
Start Date:	09/2010

Project Title:	The roles of Hoxb3 and Jag1 in mediating branchial arch defects in Six1-Eya1 associated Branchio-Oto-Renal syndrome.
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012

Project Title:	The roles of Irx3 and Irx5 genes in mammalian inner ear morphogenesis
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	The requirements of Sox10 and neuropilins in neural crest migration and gangliogenesis
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2014

Project Title:	Modulation of Notch1 receptor Intracellular Domain (NICD) stability by Eya1 phosphatase
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2015

Project Title:	The roles of Suppressor of fused (Sufu) in the maintenance of mammalian neural progenitor cells
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	ISSCR 2015; Suppressor of fused (Sufu) regulates hindbrain neural progenitor proliferation
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2015

List of Research Outputs

HU J., Bitter P., Jonas F., Sham M.H., Huang J., Lenz P. and Huang W., Quantitative Characterization of Mesenchymal Cell Aggregation Process, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

Ho J.W.Y., Knutzen K.B., Wong N.S., Chan L.K. and Sham M.H., AMEE 2014 Excellence in Education – the 21st Century Teacher, Milan, Italy, 30th Aug - 3rd Sept 2014.

Ho J.W.Y., Knutzen K.B., Wong N.S., Chan L.K. and Sham M.H., Virtually there: A journey to the HKU Medicine Island for teaching and learning, Association for Medical Education in Europe (AMEE), 30 August – 3 September 2014, Milan, Italy. 2014.

Ho J.W.Y., Wong N.S., YE L., Chan L.K. and Sham M.H., ePoster Award (Second runner up), Title: Virtually there: a journey to the HKU Medicine Island for teachnig and learning, HKU Li Ka Shing Faculty of Medicine Frontiers Series – East-West Alliance Global Symposia. 2014.

Lui J.A.J., Lai P.L., Gui H., Sham M.H., Garcia-Barcelo M.M., Hui C.C. and Ngan E.S.W., Perturbed SUFU-GLI-SOX10 regulatory network underlies defective enteric nervous system development and Hirschsprung disease, 4th International Symposium of Development of the enteric nervous system: cells, signals, genes and therapy, Rotterdam, the Netherlands, 19-22 April 2015.

ZHANG H., Wong Y.M.E., Tsang S.L., Xu P.X. and Sham M.H., Eya1 Regulates Notch Signaling in Branchial Epithelium during Craniofacial Development, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

Researcher : Sham PC

Project Title:	Replication study of susceptibility genes for colorectal cancer
Investigator(s):	Sham PC, Ho JWC, Cheng KK
Department:	LKS Medical Faculty
Source(s) of Funding:	Small Project Funding
Start Date:	10/2007

Project Title:	Partner State Key Laboratory of Brain and Cognitive Sciences
Investigator(s):	Sham PC, So KF, Tan L
Department:	Centre for Genomic Sciences
Source(s) of Funding:	Matching Fund for State Key Laboratory (SKL)
Start Date:	10/2008

Project Title:	Visiting Research Professors Scheme 2009-10
Investigator(s):	Sham PC
Department:	LKS Medical Faculty
Source(s) of Funding:	Visiting Research Professors Scheme
Start Date:	09/2009

Project Title:	To determine the functional variants of candidate genes identified by Genome-wide Association Study of Osteoporosis
Investigator(s):	Sham PC, Gao RY, Xiao S, Kung AWC
Department:	LKS Medical Faculty
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2010

Project Title:	Method and Software for Personal Risk Profiling of Complex Diseases
Investigator(s):	Sham PC, Cherny SS, Garcia-Barcelo MM, Kung AWC, Li M, Yang W
Department:	Psychiatry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012

Project Title:	Bioinformatics tools for identifying disease loci from exome sequencing data
Investigator(s):	Sham PC, Cherny SS, Garcia-Barcelo MM, Li M, Yang W
Department:	Psychiatry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	Genomics
Investigator(s):	Sham PC, Chin FYL, Leung FCC
Department:	LKS Medical Faculty
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	06/2013

Project Title:	Cross Cultural Differences in Biased Cognition
Investigator(s):	Sham PC, Chen EYH, Toulopoulou T
Department:	LKS Medical Faculty
Source(s) of Funding:	ESRC/RGC Joint Research Scheme
Start Date:	09/2013

Project Title:	Statistical methods for characterizing the genetic component of polygenic diseases
Investigator(s):	Sham PC, Cherny SS
Department:	Psychiatry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Mutational spectrum for dilated cardiomyopathy in Hong Kong
Investigator(s):	Sham PC, Tse HF, Cherny SS, Garcia-Barcelo MM, Tang SM, Li M
Department:	Centre for Genomic Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014

Project Title:	Schizophrenia-related de novo and compound heterozygous mutations
Investigator(s):	Sham PC, Chen EYH, Chang WC, Chan KW, Lee HME, Cherny SS, Li M
Department:	LKS Medical Faculty
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2015

List of Research Outputs

Lam J.H., Chow T.C., Siu K.L., Chau W.H., Ng M.H., Bao S., Ng G.C.T., Sham P.C. and Shum D.K.Y., PTPN exerts pro-neuronal survival and neuritic elongation via ErbB4/NRG3 signaling, Int J Biochem Cell Biol. 2015, 61: 53-62.

Researcher : Shen Y

List of Research Outputs

MA S.K.Y., Shen Y., Ng V.C.W., An Y., Agata K., Lam Y.W. and Chan D., Phylogenetic Analysis of Planarian Collagens and Their Roles in Regeneration, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Researcher : Shi L

List of Research Outputs

Researcher : Shum DKY

Project Title:	30th Annual Conference of Society for Neuroscience Effects of Chondroitin Sulfate Supplements on Regeneration of Bridged Sciatic Nerves
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2000

Project Title:	31st Annual Meeting of Society for Neuroscience Expression of Chondroitin 6-sulfotransferase mRNA and the Sulfation Product in Post-crush Sciatic Nerves of Adult Rats
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2001

Project Title:	Expression of heparanase in the injured spinal cord
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	33rd Annual Conference of the Society for Neuroscience Spatiotemporal Expression of Chondroitin 6-Sulfotransferase (C6ST) In Regeneration of Crush-injured Sciatic Nerves of Adult Rats C6ST Expression in Sciatic Nerve Explant Culture of Adult Rats
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2003

Project Title:	Expression of chondroitin sulfotransferases in the injured spinal cord
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Project Title:	Proteoglycans in Signaling Heparan Sulfate/Syndecan-1 Modulates the Balance between Proteinase and Anti-Proteinase in Bronchiectasis
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2005

Project Title:	Heparan sulfate oligosaccharide preparations - novel therapeutics in chronic inflammation
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	10/2007

Project Title:	Use of a rat model of chronic obstructive pulmonary disease to address neutrophil elastase/anti-elastase imbalance in the airways
Investigator(s):	Shum DKY, Ip MSM, Chan CH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	12/2008

Project Title:	A Novel Nerve Conduit that Combines Schwann Cell-seeded Chitosan Nanofibres with Chondroitinase ABC-loaded Chitosan Microbeads for Post-traumatic Nerve Regeneration
Investigator(s):	Shum DKY, Chan YS, Tam KW
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	07/2011

Project Title:	A Novel Nerve Conduit that Combines Schwann Cell-seeded Chitosan Nanofibres with Chondroitinase ABC-loaded Chitosan Microbeads for Post-traumatic Nerve Regeneration
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	07/2011

Project Title:	Proheparanase and AMPA receptor trafficking in synaptic plasticity
Investigator(s):	Shum DKY, Chan YS
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2011

Project Title:	From bone marrow stromal cells to Schwann cells – in vitro route to specification and utility in re-myelination therapy
Investigator(s):	Shum DKY, Chan YS
Department:	Biochemistry
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2012

Project Title:	Tuning sulfation of chondroitins at perineuronal nets regulate plasticity of central vestibular synapse
Investigator(s):	Shum DKY, Chan YS
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	Neuroscience 2014; Oligodendrocyte and Schwann Cell Biology - Juxtacrine signalling via Notch and ErbB receptors in the switch to fate commitment of bone marrow-derived Schwann cells.
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2014
Completion Date:	11/2014

List of Research Outputs

Botelho M.G., Lam O.L.T., Watt R.M., Yip V.S.P., Shum D.K.Y. and Lung M.A.K.Y., Peer generated MCQs to assess and support for learning in a Problem Based Learning Programme, International Conference: Assessment for Learning in Higher Education 2015. .

CHEN W., Ma C.W., DE NOGUEIRA BOTELHO F.P., HU H., LAM T.F., Lai C.H., Shum D.K.Y. and Chan Y.S., Early postnatal perturbation of inhibitory transmission in the vestibular nucleus governs the expression of spatial map and spatial navigation behaviors, Abstracts of 10th Int’l Symp. on Healthy Aging: 55. 2015.

CHEN W., Ma C.W., DE NOGUEIRA BOTELHO F.P., NG K.P., HU H., Bai Z.T., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of inhibitory transmission in the vestibular nucleus during an early postnatal stage impacts on the thalamic spatial map and spatial cognitive behaviors., Proc. 16^th Conference of Neuropsychopharamcology Wenzhou. September 25-28, 2014]. 2014.

Cai S., Chan Y.S. and Shum D.K.Y., Derivation of stable Schwann cells from human bone marrow stromal cells. Journal of Neurochemistry, 130 Suppl 1 26, [ 11^th Biennial Meeting of Asia-Pacific Society for Neurochemistry Kaohsiung, Taiwan. August 23-26, 2014]. 2014.

Cai S., Chan Y.S. and Shum D.K.Y., Directed differentiation of human induced pluripotent stem cell to sensory neurons by combined small molecule inhibitors, Soc. Neuroscience Abstract (USA) 397.12/B15. 2014.

Cai S., Chan Y.S. and Shum D.K.Y., Small molecule approach to direct differentiation of human induced pluripotent stem cells to sensory neurons, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 79. 2015.

Chan Y.S., Ma C.W., Ng K.P., Han L. and Shum D.K.Y., Glutamatergic transmission in the vestibular nucleus is critical to the formation of spatial topography and acquisition of spatial navigation in rats behaviour, Society Neuroscience Abstract (USA), 157.01/EE3. 2014.

Chan Y.S., Ma C.W., Ng K.P., Han L. and Shum D.K.Y., Glutamatergic transmission in the vestibular nucleus is critical to the formation of spatial topography and acquisition of spatial navigation in rats, Soc. Neuroscience Abstract (USA) 157.01/EE3 [Washington DC. Nov. 15-19, 2014]. 2014.

Chen C.W., Ma C.W., DE NOGUEIRA BOTELHO F.P., HU H., Lam T.F., Lai C.H., Shum D.K.Y. and Chan Y.S., Early postnatal perturbation of inhibitory transmission the vestibular nucleus governs the expression of spatial map and spatial navigation behaviors, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 55. [HK. March 7-8, 2015]. 2015.

Chow G.W., Cham W.C., Chan Y.S. and Shum D.K.Y., Role of proheparanase in regulating synaptic plasticity in rat hippocampus, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 77. 2015.

JIANG Q., SHI W., DE NOGUEIRA BOTELHO F.P., Ma C.W., Lai C.H., Shum D.K.Y. and Chan Y.S., Developmental modulation of long-term plasticity at vestibular GABAergic synapses, Journal of Neurochemistry , 130 Suppl 1: 65. 2014.

JIANG Q., Ma C.W., CHEN W., Shum D.K.Y. and Chan Y.S., Effects of fluoxetine on the restoration of plasticity in young adult vestibular nucleus, Abstracts of 10th Int’l Symp. on Healthy Aging: 80. 2015.

JIANG Q., Ma C.W., Chen C.W., Shum D.K.Y. and Chan Y.S., Effects of fluoxetine on the restoration of plasticity in young adult vestibular nucleus, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 80. 2015.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Regulatory role of perineuronal nets and semaphorin3A in the developmental maturation of the central vestibular circuitry, Abstracts of 9^th FENS Forum of Neuroscience, 2454. 2014.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., The involvement of perineuronal semaphorin 3A and chondroitin sulfates in regulating maturation of the central vestibular circuitry, Abstracts of 10th Int’l Symp. on Healthy Aging: 79. 2015.

Kwan P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., The involvement of perineuronal semaphoring 3A and chondroitin sulfates in regulating maturation of the central vestibular circuitry, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 79. 2015.

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilization of chondroitinase ABC-I and –II on chitosan microbeads improve neurite growth in CSPG-enriched astrocyte culture, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 64. 2015.

LAM K.S.F., Ma C.W., DE NOGUEIRA BOTELHO F.P., Lai C.H., SHI W., Shum D.K.Y. and Chan Y.S., NKCC1 and KCC2 cotransporters are required in postnatal maturation of the vestibular system, Abstracts of 10th Int’l Symp. on Healthy Aging: 75. 2015.

LAM K.S.F., Ma C.W., DE NOGUEIRA BOTELHO F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., Neonatal perturbation of KCC2 and NKCC1 co-transporters in the developing vestibular nucleus impairs vestibular functions, Soc. Neuroscience Abstract (USA), 157.03/EE5. 2014.

LAU W.Y., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Characterization of Heparanase 1 and Heparanase 2 at Hippocampus, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

LAU W.Y., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Role of heparanase 1 and heparanase 2 in modulating synaptic activities, Abstracts of 10th Int’l Symp. on Healthy Aging: 77. 2015.

Lam J.H., Chow T.C., Siu K.L., Chau W.H., Ng M.H., Bao S., Ng G.C.T., Sham P.C. and Shum D.K.Y., PTPN exerts pro-neuronal survival and neuritic elongation via ErbB4/NRG3 signaling, Int J Biochem Cell Biol. 2015, 61: 53-62.

Lam K.S., Ma C.W., DE NOGUEIRA BOTELHO F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., NKCC1 and KCC2 cotransporters are required in postnatal maturation of the vestibular system, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 75. 2015.

Lam W.Y., Cham W.C., Chan Y.S. and Shum D.K.Y., Role of heparanase 1 and heparanase 2 in modulating synaptic activities, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 77. 2015.

Lau W.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Expression of heparanase 1 and heparanase 2 at the hippocampus, Abstracts of 9^th FENS Forum of Neuroscience 777. [Milan, Italy. July 5-9, 2014]. 2014.

Ma C.W., Han L., Cham W.C., Chan Y.S. and Shum D.K.Y., Neuronal proheparanase regulates synaptic function of the central vestibular system., Abstracts of 9^th FENS Forum of Neuroscience 1603. 2014.

Plani-Lam J.H., Chow T.C., Siu K.L., Chau W.H., Ng M.H., Bao S., Ng C.T., Sham P.C., Shum D.K.Y., Jin D. and Song Y., PTPN21 exerts pro-neuronal survival and neuritic elongation via ErbB4/NRG3 signaling, The International Journal of Biochemistry & Cell Biology. Int J Biochem Cell Biol, 2015, 61: 53-62.

Shum D.K.Y., TAI W.Y.E., Shea G.H.K., Tsui Y.P., LEUNG H.Y. and Chan Y.S., Juxtacrine signalling via Notch and ErbB receptors in the switch to fate commitment of bone marrow-derived Schwann cells, Soc. Neuroscience Abstract (USA) 589.10/A21. 2014.

TAI W.Y.E., Shea G.K.H., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Guidance of DRG neurons in fate determination of bone marrow derived Schwann cells, 9th FENS Forum of Neuroscience. 2014.

TAI W.Y.E., Shea G.K., Leung K.H., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Instructive role of DRG neurons in derivation of Schwann cells from bone marrow stromal cells, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 57. 2015.

TUNG W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Nere guidance channel constructed by Schwann cell seeded aligned chitosan nanofiber, Journal of Neurochemistry, 130 Suppl 1: 49. 2014.

Tam K.W., Chan Y.S. and Shum D.K.Y., Stability and kinetics of chondroitinase ABC in macromolecular crowded environment, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 64. 2015.

Tsui Y.P., Shum D.K.Y. and Chan Y.S., Cell therapy for myelin disorder: derivation of two myelin-forming cell types from adult bone marrow stromal cells , Tenth International Symposium on Healthy Aging “A Decade of Positive Aging”. 2015.

Tsui Y.P., TAI W.Y.E., Shum D.K.Y. and Chan Y.S., Cell therapy for remyelination: Divergent routs for derivation of alternative glial cell fates from adult bone marrow stromal cells, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging : 56. 2015.

Tsui Y.P., Shum D.K.Y. and Chan Y.S., Divergent routes for derivation of alternative glial cell fate from adult bone marrow stromal cells for remyelination therapy, Gordon Research Conference - Molecular & Cellular Neurobiology. 2014.

Tsui Y.P., Shum D.K.Y. and Chan Y.S., Sun Chieh Yeh Young Investigator Award (Oral Category), Tenth International Symposium on Healthy Aging: A Decade of Positive Aging, Hong Kong, China. 2015.

Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Nerve conduit constructed by aligned chitosan nanofibers for directing axonal growth in nerve regeneration, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 64. 2015.

Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Nerve guidance channel constructed by Schwann cell seeded aligned chitosan nanofiber, Journal of Neurochemistry 130 Suppl 1: 49. 2014.

Wong M.K., Li M., Chan Y.S. and Shum D.K.Y., Dynamics of chondroitin sulfotransferase expression for cranial motor neuron migration in rat hindbrain development, Abstracts of 9^th FENS Forum of Neuroscience, 2470. 2014.

Researcher : Siu KL

List of Research Outputs

KEW C., Siu K.L., Chan C.P. and Kok K.H., Viral suppression of type I interferon production through PACT targeting, The Yin & Yang of the Interferon System. International Cytokine and Interferon Society Satellite Symposium. 2014.

Plani-Lam J.H., Chow T.C., Siu K.L., Chau W.H., Ng M.H., Bao S., Ng C.T., Sham P.C., Shum D.K.Y., Jin D. and Song Y., PTPN21 exerts pro-neuronal survival and neuritic elongation via ErbB4/NRG3 signaling, The International Journal of Biochemistry & Cell Biology. Int J Biochem Cell Biol, 2015, 61: 53-62.

WANG P., Siu K.L., Zhang Y., Yang W., Kok K.H. and Jin D., IFI16β and STINGβ: Negative Regulators of Innate Immunity Generated by Alternative Splicing, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

Researcher : Smith DK

Project Title:	Patterns in proteins with unusual flexibility profiles
Investigator(s):	Smith DK
Department:	Biochemistry
Source(s) of Funding:	Seed Funding for New Staff
Start Date:	08/2002

Researcher : Song Y

Project Title:	A Randomized Controlled Trial of the Therapeutic Effects of Tai Chi and Mahjong on Older Persons With Cognitive Impairment
Investigator(s):	Song Y
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2008

Project Title:	Identification of a genetic variant for heart defects (CHD) on chromosome 15 in mice
Investigator(s):	Song Y, Cheah KSE, Sham PC
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2012

Project Title:	Investigation on Pax6 regulation of neuronal apoptosis in Alzheimer’s disease
Investigator(s):	Song Y
Department:	Biochemistry
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2013

Project Title:	Study of Population Specific Linkage Disequilibrium (LD) Patterns of Human Major Histocompatibility Complex (MHC) Region for Cancers, Infectious and Autoimmunity Diseases in Southern Chinese
Investigator(s):	Song Y, Sham PC, Fan Y
Department:	Biochemistry
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014

Project Title:	The role of hnrnpa1 in human congenital heart defects
Investigator(s):	Song Y, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	05/2014

Project Title:	Repurposing the approved drugs for prevention and treatment of Alzheimer’s disease in transgenic mouse models
Investigator(s):	Song Y, Chu LW
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2014

Project Title:	Modeling host susceptibility to influenza H7N9 virus in inbred mice: a pilot study
Investigator(s):	Song Y, Yeung ML, Kok KH
Department:	Biochemistry
Source(s) of Funding:	Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential
Start Date:	10/2014

Project Title:	Targeted sequencing to identify of genes on candidate loci causing Adolescent Idiopathic Scoliosis (AIS)
Investigator(s):	Song Y, Luk KDK, Chan D, Sham PC, Cheung KMC
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2015

List of Research Outputs

Anthonappa R., King N., Rabie A. and Song Y., Novel complex disease allele mutations in cleidocranial dysplasia patients, J Oral Pathol Med. 2014, 43: 798-800.

CHENG Z., Zhou J., To K.K.W., Chu H., Li C., Song Y., Zheng B. and Yuen K.Y., Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza., Journal of Infectious Diseases. 2015.

Cheung J.P.Y., Samartzis D., Kao P., Shigematsu P., Cheah K.S.E., Song Y., Sham P.C., Chan D. and Cheung K.M.C., Developmental lumbar spinal stenosis in Southern Chinese: findings from a genome-wide association study., Combined Academic Conference of the 18th Biennial Congress of the Asia Pacific Orthopaedic Association and the 36th Annual Meeting of the Royal College of Orthopaedic Surgeons of Thailand. Pattaya, Thailand. October 23-25, 2014.. 2014.

Cheung J.P.Y., Samartzis D., Kao P.Y.P., Shigematsu H., Cheah K.S.E., Song Y., Sham P.C., Chan D. and Cheung K.M.C., Developmental lumbar spinal stenosis in Southern Chinese: findings from a genome-wide association study, Combined Academic Conference of the 18th Biennial Congress of the Asia Pacific Orthopaedic Association and the 36th Annual Meeting of the Royal College of Orthopaedic Surgeons of Thailand. Pattaya, Thailand, 2014.

Ko J.M.Y., Zhang P., Law S.Y.K., Fan Y., Song Y., Zhao X.K., Wong H.W.E., Tang S., Song X., Lung M.L. and Wang L.D., Identity-by-descent approaches identify regions of importance for genetic susceptibility to hereditary esophageal squamous cell carcinoma, Oncology Reports. 2014, 32(2): 860-870.

LI J., Sham P.C., Song Y. and Li M.X., SPS: A Simulation Tool for Calculating Power of Set-based Genetic Association Tests, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

LI Y., Samartzis D., Campbell D., Cherny S., Cheung K.M.C., Luk K.D.K., Karppinen J., Song Y., Cheah K.S.E., Sham P.C. and Chan D., A novel pathway associated with lumbar disc degeneration: a genome-wide association study, 42nd Annual Meeting of International Society for the Study of the Lumbar Spine, San Francisco, USA, June 8-12, 2015.

LI Y., Kao P., Yip M.S., Sze K.L., Fosang A., McCulloch D., Cheung K.M.C., Samartzis D., Luk K.D.K., Karppinen J., Song Y., Cheah K.S.E., Sham P.C. and Chan D., Association and functional analysis of ADAMTSS in lumbar disc degeneration, 42nd Annual Meeting of International Society for the Study of the Lumbar Spine, San Francisco, USA, June 8-12, 2015.

Li Y., Samartzis D., Campbell D., Cherny S., Cheung K.M.C., Luk K.D.K., Karppinen J.I., Song Y., Cheah K.S.E., Sham P.C. and Chan D., A novel pathway associated with lumbar disc degeneration: a genome-wide association study, 42nd International Society for the Study of the Lumbar Spine. San Francisco, 2015.

Li Y., Kao P.Y.P., Yip M.S., Sze K.L., Fosang A., McCulloch D., Cheung K.M.C., Samartzis D., Luk K.D.K., Karppinen J.I., Song Y., Cheah K.S.E., Sham P.C. and Chan D., Association and functional analysis of ADAMTS5 in lumbar disc degeneration, 42nd International Society for the Study of the Lumbar Spine. San Francisco, 2015.

NG G.C.T. and Song Y., The Role and Imaging of PAX6 in a Mouse Model of Alzheimer's Disease, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Plani-Lam J.H., Chow T.C., Siu K.L., Chau W.H., Ng M.H., Bao S., Ng C.T., Sham P.C., Shum D.K.Y., Jin D. and Song Y., PTPN21 exerts pro-neuronal survival and neuritic elongation via ErbB4/NRG3 signaling, The International Journal of Biochemistry & Cell Biology. Int J Biochem Cell Biol, 2015, 61: 53-62.

Van der S.S., Dolan C.V., Li J., Song Y., Sham P.C., Posthuma D. and Li M., MGAS: a powerful tool for multivariate gene-based genome-wide association analysis, Bioinformatics. 2015, 31: 1007-1015.

ZHANG Y., Song Y., Samartzis D., Bow C., Cheah K.S.E., Cheung M.C.H., Sham P.C., Chan D. and Leung K.K.H., Genetic risks for chronic periodontitis: preliminary data of a genome-wide association study., International Association for Dental Research Pan European Region Congress. Dubrovnik, Croatia. September 10-13, 2014.. 2014.

Zheng Y., Song Y., Samartzis D., Bow H.Y.C., Cheah K.S.E., Cheung K.M.C., Sham P.C., Chan D. and Leung W.K., Genetic risks for chronic periodontitis: preliminary data of a genome-wide association study, International Association for Dental Research Pan European Region Congress. Dubrovnik, Croatia, 2014.

Researcher : Sze KL

List of Research Outputs

LI Y., Kao P., Yip M.S., Sze K.L., Fosang A., McCulloch D., Cheung K.M.C., Samartzis D., Luk K.D.K., Karppinen J., Song Y., Cheah K.S.E., Sham P.C. and Chan D., Association and functional analysis of ADAMTSS in lumbar disc degeneration, 42nd Annual Meeting of International Society for the Study of the Lumbar Spine, San Francisco, USA, June 8-12, 2015.

Researcher : Szeto YY

Project Title:	Transcriptional regulation of Aqp3 by Sox9 and Sox9Y440X in the mouse inner ear
Investigator(s):	Szeto YY, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	05/2012

Researcher : TANG SLM

List of Research Outputs

TANG S.L.M., Godonoga M., DIRKZWAGER R.M., KINGHORN A.B., Heddle J. and Tanner J.A., DNA Origami Integrated to Aptamer-mediated Molecular Recognition, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Researcher : TANG X

List of Research Outputs

TANG X., Huang J. and Guan X., ASCL1 is Essential in Maintaining CD133+ Cancer Stem Cells in HCC, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Researcher : TSUI MG

List of Research Outputs

TSUI M.G., PDZD2, a candidate for Brachydactyly Type A1, encodes a secreted protein that negatively modulates Hedgehog signaling, PhD Thesis, The University of Hong Kong. 2014.

Researcher : TUNG WT

List of Research Outputs

TUNG W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Nere guidance channel constructed by Schwann cell seeded aligned chitosan nanofiber, Journal of Neurochemistry, 130 Suppl 1: 49. 2014.

TUNG W.T., Preparation of electrospun chitosan fibres for Schwann cell-guided axonal growth , MPhil Thesis, The University of Hong Kong. 2014.

Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Nerve Conduit Constructed by Aligned Chitosan Nanofibers for Directing Axonal Growth in Nerve Regeneration, 10^th International Symposium on Healthy Aging: A Decad of Positive Aging. 2015.

Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Nerve conduit constructed by aligned chitosan nanofibers for directing axonal growth in nerve regeneration, Abstracts of 10^th Int’l Symp. on Healthy Aging: A Decade of Positive Aging: 64. 2015.

Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Nerve guidance channel constructed by Schwann cell seeded aligned chitosan nanofiber, Journal of Neurochemistry 130 Suppl 1: 49. 2014.

Researcher : Tai CP

Project Title:	Conservation of chordate SOXE protein function in chondrogenesis
Investigator(s):	Tai CP, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	02/2012

Researcher : Tam JWO

Project Title:	14th Annual San Diego Conference: Nucleic Acid Technologies in Disease Detection Direct Flow-Through Hybridisation Device: An Effective and Lost Cost Apparatus for Rapid DNA Analysis
Investigator(s):	Tam JWO
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/1999

Researcher : Tam KW

List of Research Outputs

Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Nerve guidance channel constructed by Schwann cell seeded aligned chitosan nanofiber, Journal of Neurochemistry 130 Suppl 1: 49. 2014.

Researcher : Tam V

Project Title:	Computational Mass Spectrometry-Based Proteomics, 6th MaxQuant Summer School; Using proteomics to identify changes from health to degeneration in the intervertebral disc.
Investigator(s):	Tam V
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2014
Completion Date:	07/2014

Project Title:	Understanding the role of clusterin in intervertebral disc degeneration
Investigator(s):	Tam V, Chan D
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	06/2015

List of Research Outputs

Cheung J.P.Y., Cheung W.H.P., Samartzis D., Tam V., Leung V.Y.L. and Cheung K.M.C., Significance of ligamentum flavum hypertrophy in developmental spinal stenosis, Combined Congress of the 12th Hong Kong International Orthopaedic Forum, 10th Combined Congress of the Asia Pacific Spine Society, and the Asia Pacific Paediatric Orthopaedic Society. Hong Kong, 2015.

SUN Y., Lv M., ZHOU L., Tam V., Lv F., Chan D., Wang H., Zheng Z., Cheung K.M.C. and Leung V.Y.L., Enrichment of committed human nucleus pulposus cells expressing chondroitin sulfate proteoglycans under alginate encapsulation, Osteoarthritis Cartilage. 2015, 23: 1194-1203.

Tam V., Yee F.Y.A., Sharma R., Cheung K.M.C., Cheah K.S.E., Lam Y.W. and Chan D., Disc cell responses to the local environment of degenerated and non-degenerated intervertebral disc tissue , Orthopaedic Research Society Annual Meeting, March 28th-31st, Las Vegas, USA. 2015.

Researcher : Tan Z

List of Research Outputs

WEN S., Tan Z., Hui C.C. and Cheah K.S.E., Functional Roles for Irx3 and Irx5 in Skeletal Development, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

WEN S., Tan Z., Hui C.C. and Cheah K.S.E., Functional roles for Irx3 and Irx5 in osteoblast differentiation, Cold Spring Harbour Asia meeting in Suzhou(China), 3-7 Nov, 2014.

WEN S., Tan Z., Hui C.C. and Cheah K.S.E., Poster Presentation Award "Functional Roles for Irx3 and Irx5 in Skeletal Development", 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

YAO Q., Chan W.C.W., Ng V.C.W., Tan Z., Tsang K.Y., Cheah K.S.E. and Chan D., Hypertrophic Chondrocytes under ER Stress Utilizes the Hypoxia Stress Signals for Survival, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Researcher : Tang HC

List of Research Outputs

Yang L., Tsang K.Y., Tang H.C., Chan D. and Cheah K.S.E., Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation, Proc Nat Acad Sci. 2014, published ahead of print: doi:10.1073/pnas.1302703111.

Yang L., Tsang K.Y., Tang H.C., Chan D. and Cheah K.S.E., Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation, Proc Natl Acad Sci U S A. 2014, 111(33): 12097-102.

Researcher : Tang HMV

List of Research Outputs

CHENG Y., Tang H.M.V., GAO W., Deng J., Chan C.P. and Jin D., Ubiquitination and Proteosomedependent Degradation of the Activated Form of Human Liver-enriched Transcription Factor CREB- H, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

Tang H.M.V., Gao W., Chan C.P., Cheng Y., Chaudhary V., Deng J., Yuen K.S., Wong C.M., Ng I.O.L., Kok K.H., Zhou J. and Jin D., Requirement of CRTC1 coactivator for hepatitis B virus transcription, Nucleic Acids Res. 2014, 42(20): 12455-68.

Researcher : Tanner J.A.

Project Title:	Comparative Characterization of the Two Polyphosphate Kinases of M. tuberculosis
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2005

Project Title:	Defining the Roles of the Fundamental Macromolecule Inorganic Polyphosphate in Osteoblasts
Investigator(s):	Tanner JA, Watt RM
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	Investigating the Potential of 3-D Printing as a Transformative Technology for Point of Care Diagnostics
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	05/2013
Completion Date:	10/2014

Project Title:	3-D Printed Aptamer-Enabled Diagnostic Dominoes for Malaria
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Aptamer-mediated detection of luteinizing hormone pulsatility – a transformational approach towards managing infertility
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

Project Title:	Aptamer-mediated Point-of-Care Diagnostics (CRF)
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Seed Funding for Incubating Group-based Collaborative Research Projects
Start Date:	01/2015

Project Title:	DNA origami interfaced with aptamer-mediated molecular recognition for integrated modular diagnostics
Investigator(s):	Tanner JA, Watt RM
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Aptamers 2015 and Oligomer 2015 at Oxford University; Aptamer 2015: DNA aptamers for point-of-care malaria diagnosis - from crystal structure to clinical application using Aptamer Tethered Enzyme Capture (APTEC)/Oligo 2015: Highly selective DNA oligonucleotide aptamers against aggrecanase ADAMTS5 for degenerative disc disease therapy
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2015

Project Title:	Tetrapod Palindromic Capture Aptamers for Diagnostic Devices
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2015

List of Research Outputs

Researcher : Tanner JA

Project Title:	Comparative Characterization of the Two Polyphosphate Kinases of M. tuberculosis
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2005

Project Title:	Defining the Roles of the Fundamental Macromolecule Inorganic Polyphosphate in Osteoblasts
Investigator(s):	Tanner JA, Watt RM
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	Investigating the Potential of 3-D Printing as a Transformative Technology for Point of Care Diagnostics
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	05/2013
Completion Date:	10/2014

Project Title:	3-D Printed Aptamer-Enabled Diagnostic Dominoes for Malaria
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Aptamer-mediated detection of luteinizing hormone pulsatility – a transformational approach towards managing infertility
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

Project Title:	Aptamer-mediated Point-of-Care Diagnostics (CRF)
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Seed Funding for Incubating Group-based Collaborative Research Projects
Start Date:	01/2015

Project Title:	DNA origami interfaced with aptamer-mediated molecular recognition for integrated modular diagnostics
Investigator(s):	Tanner JA, Watt RM
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Aptamers 2015 and Oligomer 2015 at Oxford University; Aptamer 2015: DNA aptamers for point-of-care malaria diagnosis - from crystal structure to clinical application using Aptamer Tethered Enzyme Capture (APTEC)/Oligo 2015: Highly selective DNA oligonucleotide aptamers against aggrecanase ADAMTS5 for degenerative disc disease therapy
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2015

Project Title:	Tetrapod Palindromic Capture Aptamers for Diagnostic Devices
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2015

List of Research Outputs

Bevan S.J., Chan W.L. and Tanner J.A., Building creative and collaborative assessment strategies into a large introductory biomedical sciences class – evidence for sustained deep learning and potential adaptability for MOOCs., 2014 East-West Alliance Global Symposia, Hong Kong. 2014.

Bevan S.J., Chan W.L. and Tanner J.A., Diverse assessment and active student engagement sustain deep learning: A comparative study of outcomes in two parallel introductory biochemistry courses, Biochemistry and Molecular Biology Education. 2014, 42: 474-479.

DIRKZWAGER R.M., Cheung Y.W., Richards J.S. and Tanner J.A., Diagnosing malaria using DNA aptamers against P. falciparum LDH., Point of Care Diagnostics World Congress, San Diego, USA (2014). 2014.

Dirkzwager R.D., Kinghorn A.B., Richards J.S. and Tanner J.A., APTEC: aptamer-tethered enzyme capture as a novel rapid diagnostic test for malaria, Chem. Commun.. 2015, 51: 4697-4700.

FRASER L.A., DIRKZWAGER R.M., LIANG S. and Tanner J.A., Towards a Universal Aptamer Diagnostics Platform, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

HSIAO A.S., Haslam R.P., Michaelson L.V., LIAO P., Chen Q., Sooriyaarachchi S., Mowbray S.L., Napier J.A., Tanner J.A. and Chye M.L., Arabidopsis cytosolic acyl-CoA-binding proteins ACBP4, ACBP5 and ACBP6 have overlapping but distinct roles in seed development , Bioscience Reports 34: 865-877. 2014.

KHONG M.L., Li L., Szeto S.C., Watt R.M. and Tanner J.A., Cloning, Expression, Purification and Characterisation of Escherichia coli Polyphosphate Binding Domain as a New Tool to Understanding Polyphosphate Synthesis and Function, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

KINGHORN A.B. and Tanner J.A., Aptamer library resampling., 2014 East-West Alliance Global Symposia, Hong Kong. 2014.

LAI Y.T., CHANG Y.Y., Hu L., YANG Y., CHAO A., Du Z., Tanner J.A., Chye M.L., Qian C., Ng K.M., Li H. and Sun H., Rapid labeling of intracellular His-tagged proteins in living cells, Proc Natl Acad Sci USA. 2015, 112: 2948-2953.

LIANG S., Dhillo W.S., Cass A.E. and Tanner J.A., Development of an Aptamer-based Biosensing System for Measuring Luteinizing Hormone Pulsatility for Infertility Treatment, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

TANG S.L.M., Godonoga M., DIRKZWAGER R.M., KINGHORN A.B., Heddle J.G. and Tanner J.A., Best poster presentation prize, HKU 19th Research Postgraduate Symposium, Hong Kong 2014. 2014.

TANG S.L.M., Godonoga M., DIRKZWAGER R.M., KINGHORN A.B., Heddle J. and Tanner J.A., DNA Origami Integrated to Aptamer-mediated Molecular Recognition, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Tanner J.A., Chair of Conference Session: DNA Nanoscience III., International Conference on Small Science (ICSS) 2014, Hong Kong (2014). 2014.

Tanner J.A., Chair of Conference Session: Technology-accelerated Learning in the West, 2014 East-West Alliance Global Symposia, Hong Kong. 2014.

Tanner J.A., DNA aptamers for molecular recognition in medical diagnostics., 2014 International Conference on Small Science (ICSS), Hong Kong. 2014.

Wong G.T.C., Jenkins C.R., Tsang J.W.H., Chen J.Y., Chan L.C. and Tanner J.A., Finalist for Best Free Communication , Asia Pacific Medical Education Conference. 2015.

Wong G.T.C., Jenkins C.R., Tsang J.W.H., Chen J.Y., Chan L.C. and Tanner J.A., Use of film to build student empathy and enable reflective thought, Asia Pacific Medical Education Conference. 2015.

XUE Y., Xiao S., Kim J., Lung S.C., Chen L., Tanner J.A., Suh J. .A. and Chye M.L., 2014. Arabidopsis membrane-associated acyl-CoA-binding protein AtACPB1 is involved in stem cuticle formation, J. Exp. Botany 18: 5473-5483. 2014.

Researcher : Tsang KY

List of Research Outputs

Tsang K.Y., Chan D. and Cheah K.S.E., Fate of growth plate hypertrophic chondrocytes: Death or lineage extension?, Development, Growth & Differentiation. 2015, 57: 179-192.

YAO Q., Chan W.C.W., Ng V.C.W., Tan Z., Tsang K.Y., Cheah K.S.E. and Chan D., Hypertrophic Chondrocytes under ER Stress Utilizes the Hypoxia Stress Signals for Survival, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Yang L., Tsang K.Y., Tang H.C., Chan D. and Cheah K.S.E., Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation, Proc Nat Acad Sci. 2014, published ahead of print: doi:10.1073/pnas.1302703111.

Yang L., Tsang K.Y., Tang H.C., Chan D. and Cheah K.S.E., Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation, Proc Natl Acad Sci U S A. 2014, 111(33): 12097-102.

Researcher : Tsang SL

List of Research Outputs

ZHANG H., Wong Y.M.E., Tsang S.L., Xu P.X. and Sham M.H., Eya1 Regulates Notch Signaling in Branchial Epithelium during Craniofacial Development, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

Researcher : Tsang SW

Project Title:	Consequences of activation of canonical Wnt signaling pathway in hypertrophic chondrocytes and their descendents in vivo
Investigator(s):	Tsang SW, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	01/2012

Researcher : Tung WT

List of Research Outputs

TUNG W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Nere guidance channel constructed by Schwann cell seeded aligned chitosan nanofiber, Journal of Neurochemistry, 130 Suppl 1: 49. 2014.

TUNG W.T., Preparation of electrospun chitosan fibres for Schwann cell-guided axonal growth , MPhil Thesis, The University of Hong Kong. 2014.

Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Nerve guidance channel constructed by Schwann cell seeded aligned chitosan nanofiber, Journal of Neurochemistry 130 Suppl 1: 49. 2014.

Researcher : WANG B

List of Research Outputs

WANG B., The roles of Irx3/5 genes and Hedgehog signaling in mammalian cochlear development, M Phil Thesis, The University of Hong Kong. 2014.

Researcher : WANG P

List of Research Outputs

LI J., Deng S.J., WANG P., Yang W., Ho S.L., Sham P.C., Wang J.J. and Li M., wKGGSeq: A Comprehensive Strategy-Based and Disease-Targeted Online Framework to Facilitate Exome Sequencing Studies of Inherited Disorders, Human Mutation. 2015, 36: 496-503.

WANG P., Qin J., QIN Y., ZHU Y., WANG Y., LI J., Zhang M.Q. and Wang J.J., ChIP-Array 2: integrating multiple omics data to construct gene regulatory networks, Nucleic Acids Research. 2015, 43(W1): W264-9.

WANG P., Siu K.L., Zhang Y., Yang W., Kok K.H. and Jin D., IFI16β and STINGβ: Negative Regulators of Innate Immunity Generated by Alternative Splicing, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

WANG Y., WANG P., Xia Z., Lian Q., Zhang M.Q. and Wang J.J., EATdb: A Database of Human Enhancers and Their Putative Targets, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

YALAMANCHILI H.K., LI Z., WANG P., Wong M.P., Yao J.J. and Wang J.J., SpliceNet: recovering splicing isoform-specific differential gene networks from RNA-Seq data of normal and diseased samples, Nucleic Acids Research. 2014, 42 (15): e121.

Researcher : WANG P

List of Research Outputs

Researcher : WANG W

List of Research Outputs

WANG W., A Fast and Accurate Model to Detect Germline SNPs and Somatic SNVs with High-Throughput Sequencing , PhD Thesis, The University of Hong Kong. 2014.

Zhang Y., LIANG X., Liao S., Wang W., Wang J.J., LI X., Ding Y., LIANG Y., GAO F., Yang M., Fu Q., Xu A., Chai Y.H., He J., Tse H.F. and Lian Q., Potent Paracrine Effects of human induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Attenuate Doxorubicin-induced Cardiomyopathy, Scientific Reports. 2015, 5: 11235.

Researcher : WANG Y

List of Research Outputs

WANG P., Qin J., QIN Y., ZHU Y., WANG Y., LI J., Zhang M.Q. and Wang J.J., ChIP-Array 2: integrating multiple omics data to construct gene regulatory networks, Nucleic Acids Research. 2015, 43(W1): W264-9.

WANG Y., Bioinformatics Analysis of Genetic and Epigenetic Factors Regulating Gene Expression, PhD Thesis, The University of Hong Kong. 2015.

WANG Y., WANG P., Xia Z., Lian Q., Zhang M.Q. and Wang J.J., EATdb: A Database of Human Enhancers and Their Putative Targets, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Xu M., Zhao G.N., Lv X., Liu G., WANG Y., Hao D.L., Wang J.J., Liu D.P. and Liang C.C., CTCF controls HOXA cluster silencing and mediates PRC2-repressive higher-order chromatin structure in NT2/D1 cells, Molecular and Cellular Biology. 2014, 34 (20): 3867-3879.

Researcher : WEN S

List of Research Outputs

WEN S., Tan Z., Hui C.C. and Cheah K.S.E., Functional Roles for Irx3 and Irx5 in Skeletal Development, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

WEN S., Tan Z., Hui C.C. and Cheah K.S.E., Poster Presentation Award "Functional Roles for Irx3 and Irx5 in Skeletal Development", 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Researcher : WONG MK

List of Research Outputs

WONG M.K., Expression of chondroitin sulfotransferases in neural progenitor cells – Impacts on cell motility, M Phil Thesis, The University of Hong Kong. 2014.

Wong M.K., Li M., Chan Y.S. and Shum D.K.Y., Dynamics of chondroitin sulfotransferase expression for cranial motor neuron migration in rat hindbrain development, Abstracts of 9^th FENS Forum of Neuroscience, 2470. 2014.

Researcher : WONG PY

List of Research Outputs

WONG P.Y. and Wong N.S., The Effect of Pollutant-induced Cellular Stress on mRNA Stability, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Researcher : Wang JJ

Project Title:	Understanding the co-evolutionary relationship between transcription factors and their DNA binding sites for bHLH family in eukaryotes
Investigator(s):	Wang JJ, Yao KM
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2011
Completion Date:	08/2014

Project Title:	Outstanding Young Researcher Award 2011-12
Investigator(s):	Wang JJ
Department:	Biochemistry
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	01/2013

Project Title:	A computational framework to infer regulatory modules from integrative analysis of ChIP-seq and transcriptome data
Investigator(s):	Wang JJ
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013

Project Title:	Design of versatile super promoters for highly efficient mammalian gene expression
Investigator(s):	Wang JJ, Huang J
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2013
Completion Date:	05/2015

Project Title:	ISMB/ECCB 2013; Genetic variants in the next generation: detection, reprioritizing and function annotation
Investigator(s):	Wang JJ
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2013

Project Title:	A computational algorithm to identify regulators for regulatory genetic variants in cancer genomics
Investigator(s):	Wang JJ
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2014

Project Title:	A novel computational framework to identify transcription factor-DNA interaction for cancer genomics
Investigator(s):	Wang JJ, Yao KM, Wong MP
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	08/2014

Project Title:	248th ACS National Meeting & Exposition; Decoding genetic and epigenetic networks for vitamin C mediated cell reprogramming
Investigator(s):	Wang JJ
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2014
Completion Date:	08/2014

Project Title:	Understanding the effects of DNA methylation on gene expression - a computational approach
Investigator(s):	Wang JJ, Wong MP, Chim JCS
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2015

List of Research Outputs

GAO X., Lin C., Kwan T.K., Lee V.H.F., Chan S.H., Sihoe D.L.A., Au S.K., Tin P.C., XIAO Z., Yam J.W.P., Wang J.J., Sham P.C. and Wong M.P., Application of whole exome sequencing in metachronous lung cancers evaluation, European Association for Cancer Research, Cambridge. 2015.

Li M.J., Liu Z., Wang P., Wong M.P., Yeager M., Sham P.C., Chanock S.J., Xia Z. and Wang J.J., A Comprehensive Database for GWAS ¬identified Human Genetic Variants: An Update of GWASdb, The 2015 American College of Medical Genetics and Genomics (ACMG) Annual Clinical Genetics Meeting, Salt Lake City, US, 24-28 Mar 2015.. 2015.

WANG Y., Xu F., Hu L., QUAN Q., TSANG C.N., Chu I.K. and Wang J.J., An Integrated Metalloproteomic Analysis Depicts the Proteomic Features of Helicobacter Pylori in Response to Bi(III), The 17th International Conference on Biological Inorganic Chemistry (ICBIC-17), Beijing, China, July 20-24, 2014.

WANG Y., Xu F., Hu L., QUAN Q., TSANG C.N., Chu I.K., Wang J.J. and Sun H., An Integrated Metalloproteomic Analysis Depicts the Proteomic Features of Helicobacter Pylori in Response to Bi(III), The 5th Asian Conference on Coordination Chemistry (ACCC-5), Hong Kong, July 12-16, 2014.

WANG Y., WANG P., Xia Z., Lian Q., Zhang M.Q. and Wang J.J., EATdb: A Database of Human Enhancers and Their Putative Targets, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Wang J.J., Academic Editor, 2013-present, PLoS ONE. 2014.

Wang J.J., Decoding genetic and epigenetic networks for vitamin C mediated cell reprogramming, ChemEpInformatics: In the pursuit of epidrugs using chemoinformatics and computational approaches, ACS National meeting, San Francisco, CA, August 10-14, 2014. 2014.

Wang J.J., Editor, 2013-present, Journal of Metabolomics and Systems Biology. 2014.

Wang J.J., Editorial Board Member, 2011- present., TSWJ Computational Biology. 2014.

Wang J.J., Editorial Board Member, 2012-present, Enzyme Engineering. 2014.

Wang J.J., Highlight Session Chair, The 8th International Conference on Systems Biology and the 4th Translational Bioinformatics Conference, 25-27 Oct, 2014, Qingdao, China. 2014.

Wang J.J., PC Member, IEEE International Conference Bioinformatics and Biomedicine (BIBM), 2nd-5th Nov., 2014, Belfast, UK. 2014.

Wang J.J., PC Member, International Conference on Intelligent Computing (ICIC), 3-6 Aug., 2014, Taiyuan, China. 2014.

Wang J.J., PC member, The 8th International Conference on Systems Biology and the 4th Translational Bioinformatics Conference, 25-27 Oct, 2014, Qingdao, China. 2014.

Wang P., Qin J., Qin Y., Zhu Y., Wang L.Y., Li M.J., Zhang M.Q. and Wang J.J., ChIP-Array 2: integrating multiple omics data to construct gene regulatory networks, The 2015 Mathematics, Computer and Life Sciences Interdisciplinary Research Young Scholars Forum, University of Chinese Academy of Sciences, Beijing, China, 16-17 May 2015.. 2015.

Wang P., Wang L.Y., Lian Q., Zhang M.Q., Xia Z. and Wang J.J., EATdb: a database of human enhancers and their putative targets, The 2015 American College of Medical Genetics and Genomics (ACMG) Annual Clinical Genetics Meeting, Salt Lake City, US, 24-28 March 2015.. 2015.

Xu M., Zhao G.N., Lv X., Liu G., WANG Y., Hao D.L., Wang J.J., Liu D.P. and Liang C.C., CTCF controls HOXA cluster silencing and mediates PRC2-repressive higher-order chromatin structure in NT2/D1 cells, Molecular and Cellular Biology. 2014, 34 (20): 3867-3879.

YALAMANCHILI H.K., LI Z., WANG P., Wong M.P., Yao J.J. and Wang J.J., SpliceNet: recovering splicing isoform-specific differential gene networks from RNA-Seq data of normal and diseased samples, Nucleic Acids Research. 2014, 42 (15): e121.

Yu Y., Qin J., Chen D., Wang H., Wang J.J. and Yu Y., Chronic Cardiovascular Disease-Associated Gene Network Analysis in Human Umbilical Vein Endothelial Cells Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin, Cardiovascular Toxicology. 2014, 15 (2): 157-171.

Zhang Y., LIANG X., Liao S., Wang W., Wang J.J., LI X., Ding Y., LIANG Y., GAO F., Yang M., Fu Q., Xu A., Chai Y.H., He J., Tse H.F. and Lian Q., Potent Paracrine Effects of human induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Attenuate Doxorubicin-induced Cardiomyopathy, Scientific Reports. 2015, 5: 11235.

Researcher : Wang X

List of Research Outputs

Wang X., Best Poster Presentation, Cartilage Biology & Pathology (grs) Gordon-kenan Research Seminar, Texas, Us . 2015.

Wang X., Molecular And Cellular Consequences Of Indian Hedgehog Mutations Causing Brachydactylies, Cartilage Biology & Pathology (grs) Gordon-kenan Research Seminar, Texas, Us cartilage Biology & Pathology (grc) Gordon-kenan Research Conference, Texas, Us. 2015.

Researcher : Wong EYM

Project Title:	Boc associates with Cdo to negatively regulate sensory hair cell specification in Shh signaling pathway
Investigator(s):	Wong YME, Sham MH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	11/2013
Completion Date:	12/2014

Project Title:	The role of Six1 in controlling the microtubule polymerization during inner ear hair cell bundle formation
Investigator(s):	Wong YME, Sham MH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2015

Project Title:	Genetic analyses of Cdo and Boc function in inner ear development
Investigator(s):	Wong YME, Sham MH
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Association for Research in Otolaryngology, 38th Annual MidWinter Meeting; Roles of Hedgehog co-receptors Cdo and Boc in the developing mouse inner ear
Investigator(s):	Wong YME
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	02/2015
Completion Date:	02/2015

List of Research Outputs

Researcher : Wong MK

List of Research Outputs

WONG M.K., Expression of chondroitin sulfotransferases in neural progenitor cells – Impacts on cell motility, M Phil Thesis, The University of Hong Kong. 2014.

Researcher : Wong NS

Project Title:	Kappa-opioid receptor mediated cellular stress response: the role of Inositol 1,4,5-trisphosphate and diacylglycerol
Investigator(s):	Wong NS, Yao KM
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2002

Project Title:	Hydrogen peroxide signaling - the role of thioredoxin reductase
Investigator(s):	Wong NS
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013

Project Title:	The relatioship between glycolysis and gluconeogenesis in cancer cells
Investigator(s):	Wong NS
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2014

List of Research Outputs

Ho J.W.Y., Knutzen K.B., Wong N.S., Chan L.K. and Sham M.H., AMEE 2014 Excellence in Education – the 21st Century Teacher, Milan, Italy, 30th Aug - 3rd Sept 2014.

Ho J.W.Y., Knutzen K.B., Wong N.S., Chan L.K. and Sham M.H., Virtually there: A journey to the HKU Medicine Island for teaching and learning, Association for Medical Education in Europe (AMEE), 30 August – 3 September 2014, Milan, Italy. 2014.

Ho J.W.Y., Wong N.S., YE L., Chan L.K. and Sham M.H., ePoster Award (Second runner up), Title: Virtually there: a journey to the HKU Medicine Island for teachnig and learning, HKU Li Ka Shing Faculty of Medicine Frontiers Series – East-West Alliance Global Symposia. 2014.

WONG P.Y. and Wong N.S., The Effect of Pollutant-induced Cellular Stress on mRNA Stability, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Researcher : Wong XHL

Project Title:	FEBS EMBO 2014 Conference; The Interplay between MT1-MMP and ADAMs
Investigator(s):	Wong XHL
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2014
Completion Date:	09/2014

Project Title:	The Biological Functions of MT1-MMP in Lymphatic Vascular Development
Investigator(s):	Wong XHL, Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	02/2015

Researcher : Wong YME

Project Title:	Boc associates with Cdo to negatively regulate sensory hair cell specification in Shh signaling pathway
Investigator(s):	Wong YME, Sham MH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	11/2013
Completion Date:	12/2014

Project Title:	The role of Six1 in controlling the microtubule polymerization during inner ear hair cell bundle formation
Investigator(s):	Wong YME, Sham MH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2015

Project Title:	Genetic analyses of Cdo and Boc function in inner ear development
Investigator(s):	Wong YME, Sham MH
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Association for Research in Otolaryngology, 38th Annual MidWinter Meeting; Roles of Hedgehog co-receptors Cdo and Boc in the developing mouse inner ear
Investigator(s):	Wong YME
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	02/2015
Completion Date:	02/2015

List of Research Outputs

ZHANG H., Wong Y.M.E., Tsang S.L., Xu P.X. and Sham M.H., Eya1 Regulates Notch Signaling in Branchial Epithelium during Craniofacial Development, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

Researcher : Wu MH

List of Research Outputs

Cheung M.C.H., HO S.H., Hui M.N., Wu M.H., Cheung M.P.L., Ho C.K.Y., Niu B., Cheah K.S.E. and LIU A., Sox9 and the Molecular Network Regulating Neural Crest Cell Motility, 2014 International SOX Research Conference. 2014.

Researcher : XIE S

List of Research Outputs

XIE S., LU Y., Jakoncic J., Sun H., XIA J. and Qian C., Structure of RPA32 bound to the N-terminus of SMARCAL1 redefines the binding interface between RPA32 and its interacting proteins., FEBS Journal. Europe, Wiley, 2014, 281(15): 3382-96.

XIE S., Mortuewicz O., Ma K., Poon R., Helleday T. and Qian C., Timeless interacts with Parp1 to promote homologous recombination repair, Gordon Research Conference on Genomic Instability. 2014.

Researcher : XU C

List of Research Outputs

LIN Q., XU C., Lee M., Yu B. and Huang J., Exploring the Mechanisms of Salmonella-induced Reduction of Cancer Metastasis, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

Researcher : XU F

List of Research Outputs

Gan J., Wang C., Jin Y., Guo Y., XU F., Zhu Q., Ding L., Shang H., Wang J.J., Wei F., Cai Q. and Robertson E.S., Proteomic profiling identifies the SIM-associated complex of KSHV-encoded LANA, PROTEOMICS. 2015, 15: 2023-2037.

WANG Y., Xu F., Hu L., QUAN Q., TSANG C.N., Chu I.K. and Wang J.J., An Integrated Metalloproteomic Analysis Depicts the Proteomic Features of Helicobacter Pylori in Response to Bi(III), The 17th International Conference on Biological Inorganic Chemistry (ICBIC-17), Beijing, China, July 20-24, 2014.

WANG Y., Xu F., Hu L., QUAN Q., TSANG C.N., Chu I.K., Wang J.J. and Sun H., An Integrated Metalloproteomic Analysis Depicts the Proteomic Features of Helicobacter Pylori in Response to Bi(III), The 5th Asian Conference on Coordination Chemistry (ACCC-5), Hong Kong, July 12-16, 2014.

Researcher : Xu F

List of Research Outputs

Researcher : YALAMANCHILI HK

List of Research Outputs

Hu J., Zhao Z., Yalamanchili H.K., Wang J.J., Ye K. and Fan X., Bayesian detection of embryonic gene expression onset in C. elegans, The Annals of Applied Statistics. 2015, 9: 950-968.

QIN Y., YALAMANCHILI H.K., Qin J., Yan B. and Wang J.J., The Current Status and Challenges in Computational Analysis of Genomic Big Data, Big Data Research. 2015, 2: 12-18.

YALAMANCHILI H.K., LI Z., WANG P., Wong M.P., Yao J.J. and Wang J.J., SpliceNet: recovering splicing isoform-specific differential gene networks from RNA-Seq data of normal and diseased samples, Nucleic Acids Research. 2014, 42 (15): e121.

Researcher : YANG X

List of Research Outputs

YANG X., Hu X. and Zhou Z., Novel Post Transcriptional Modification of UHRF1 and Its Biological Relevance, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

ZHOU P., O W., Yang X. and Cheung H.Y.Z., Potential Role of Atg16L1 in Autophagic Vesicle Trafficking in Primary Cultured Neurons, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Researcher : YAO Q

List of Research Outputs

Kudelko M.A., Chan C.C.Y., YAO Q., Cheah K.S.E., Tanner J.A. and Chan D., Hypertrophic Chondrocytes Survive ER Stress by Maintaining Glycolysis and Mitochondrial Membrane Poloarity., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.

YAO Q., Chan W.C.W., Ng V.C.W., Tan Z., Tsang K.Y., Cheah K.S.E. and Chan D., Hypertrophic Chondrocytes under ER Stress Utilizes the Hypoxia Stress Signals for Survival, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

YAO Q., Chan W.C.W., Ng V.C.W., Tan Z., Tsang K.Y., Cheah K.S.E. and Chan D., Hypertrophic chondrocytes under ER stress utilizes the hypoxia stress pathway for survival., Cartilage Biology & Pathology Gordon-Kenan Research Seminar. Galveston, TX, USA, March 21-22, 2015.. 2015.

Researcher : YIP KHR

List of Research Outputs

YIP K.H.R., Au Y.K., Yang W., Cheung M.C.H., Chan D. and Cheah K.S.E., Towards Understanding Genetic and Molecular Etiology of Campomelic Dysplasia, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

Researcher : YU Z

List of Research Outputs

YU Z., Identification of Master Regulators in Non-small-cell Lung Carcinoma, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Researcher : Yang X

List of Research Outputs

Researcher : Yao KM

Project Title:	Regulation of Bmi-1 expression by the Forkhead box transcription factor FoxM1
Investigator(s):	Yao KM
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2007

Project Title:	Investigating the role of FOXM1 in the maintenance of human embryonic stem cell pluripotency and genome stability
Investigator(s):	Yao KM, Cheung MCH
Department:	Biochemistry
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2012

Project Title:	Secreted PDZ domain-containing protein 2 and regulation of Sonic hedgehog signaling during neural tube development
Investigator(s):	Yao KM, Cheung MCH
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	Elucidating the nuclear function of EPS8/EPS8L2: Crosstalk with FOXM1 and regulation of cancer cell proliferation and migration/invasion
Investigator(s):	Yao KM, Chan DW
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2014

Project Title:	Identifying the cognate receptor of secreted PDZD2
Investigator(s):	Yao KM
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2015

List of Research Outputs

CAI C., Shi L., Liu V.W.S., TANG W.M., LIU J., Leung T.H.Y., Chan K.K.L., Yam J.W.P., Yao K.M., Ngan H.Y.S. and Chan D.W., Elevated TAK1 augments tumor growth and metastatic capacities of ovarian cancer cells through activation of NF-κB signaling , 2014.

CAI C., SHI L., Liu V.W.S., TANG W.M., LIU J., Leung T.H.Y., Chan K.K.L., Yam J.W.P., Yao K.M., Ngan H.Y.S. and Chan D.W., Elevated TAK1 augments tumor growth and metastatic capacities of ovarian cancer cells through activation of NF-κB signaling, Oncotarget. USA, Impact Journals, LLC., 2014, 5: 7549-62.

Lo A.C.Y., WONG S.Y., Yao K.M. and Chan B.P., Terminable cell-based GDNF delivery device for intravitreal applications, ARVO 2015 Annual Meeting. 2015.

SO H.F. and Yao K.M., Investigating the Effects of Glucose Levels on PDZD2 Levels in Rat Insulinoma INS-1E Cells, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

WONG S.Y., Yao K.M., Chan B.P. and Lo A.C.Y., Dual-Functional Encapsulated-Cell Therapy Implant for retinal diseases: sustained intraocular GDNF delivery and controlled termination, Tenth International Symposium on Healthy Aging: “A Decade of Positive Aging”. 2015.

WONG S.Y., Yao K.M., Chan B.P. and Lo A.C.Y., Runner-up in Visual Sciences, The 3rd Li Ka Shing Foundation International Research Student Forum, Sep 25, 2014, Joint Shantou International Eye Center, The Chinese University of Hong Kong. 2014.

Yao K.M., Tipoe G.L. and Vackova D., HKU MBBS Y1 IASM Block, PBL case 2 Ah Fai 2015-2016 (Teaching material PBL case writing), HKU, LKS Faculty of Medicine. 2015.

Researcher : Yee FYA

List of Research Outputs

Tam V., Yee F.Y.A., Sharma R., Cheung K.M.C., Cheah K.S.E., Lam Y.W. and Chan D., Disc cell responses to the local environment of degenerated and non-degenerated intervertebral disc tissue , Orthopaedic Research Society Annual Meeting, March 28th-31st, Las Vegas, USA. 2015.

Researcher : Yip MS

List of Research Outputs

LI Y., Kao P., Yip M.S., Sze K.L., Fosang A., McCulloch D., Cheung K.M.C., Samartzis D., Luk K.D.K., Karppinen J., Song Y., Cheah K.S.E., Sham P.C. and Chan D., Association and functional analysis of ADAMTSS in lumbar disc degeneration, 42nd Annual Meeting of International Society for the Study of the Lumbar Spine, San Francisco, USA, June 8-12, 2015.

Researcher : Yu B

Project Title:	Study of LPS effect in Salmonella-tumor interactions by using intravital imaging in vivo
Investigator(s):	Yu B, Huang J
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	01/2015

List of Research Outputs

LIN Q., XU C., Lee M., Yu B. and Huang J., Exploring the Mechanisms of Salmonella-induced Reduction of Cancer Metastasis, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

Zhang B., HUA Y., Yu B., Lau C.Y., Cai J., Zheng S.Y., Yam W.C., Kao R.Y.T., Sze K.H., Zheng B., Yuen K.Y. and Huang J., Recombinant ESAT-6-Like Proteins Provoke Protective Immune Responses against Invasive Staphylococcus aureus Disease in a Murine Model, Infection and Immunity. 2015, 83: 339-345.

Researcher : Yuen KS

List of Research Outputs

Tang H.M.V., Gao W., Chan C.P., Cheng Y., Chaudhary V., Deng J., Yuen K.S., Wong C.M., Ng I.O.L., Kok K.H., Zhou J. and Jin D., Requirement of CRTC1 coactivator for hepatitis B virus transcription, Nucleic Acids Res. 2014, 42(20): 12455-68.

Yuen K.S., Chan C.P., Wong N.H.M., HO C.H., HO T.H., Lei T., Deng W., Tsao G.S.W., Chen H., Kok K.H. and Jin D., CRISPR/Cas9-mediated genome editing of Epstein-Barr virus in human cells, Journal of General Virology. 2015, 96: 626-636.

Yuen K.S., Lei T., Kok K.H. and Jin D., Role of Epstein-Barr virus-encoded BART microRNAs in viral infection and transformation of nasopharyngeal epithelial cells, The Croucher Foundation Advanced Study Institute on “Advances in Nasopharyngeal Carcinoma Studies”.. 2014.

Researcher : ZHANG H

List of Research Outputs

ZHANG H., Wong Y.M.E., Tsang S.L., Xu P.X. and Sham M.H., Eya1 Regulates Notch Signaling in Branchial Epithelium during Craniofacial Development, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

Researcher : ZHANG S

List of Research Outputs

ZHANG S. and Zhou Z., Role of Membrane Type-I Matrix Metalloproteinase (MT1-MMP) in Mouse Intestinal Development, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Researcher : ZHENG F

List of Research Outputs

Wang X., Yu H., Xu L., Zhu T., ZHENG F., Fu C., Wang Z. and Dou Z., Dynamic Autophosphorylation of Mps1 Kinase Is Required for Faithful Mitotic Progression, PLoS ONE. 2014, 9: e104723.

ZHENG F., LI T., Jin D., Syrovatkinac V., Scheffler K., Tran P. and Fu C., Csi1p recruits alp7p/TACC to the spindle pole bodies for bipolar spindle formation, Molecular Biology of the Cell. 2014, 25: 2750-2760.

Researcher : ZHOU P

List of Research Outputs

ZHOU P., O W., Yang X. and Cheung H.Y.Z., Potential Role of Atg16L1 in Autophagic Vesicle Trafficking in Primary Cultured Neurons, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Researcher : ZHU Y

List of Research Outputs

WANG P., Qin J., QIN Y., ZHU Y., WANG Y., LI J., Zhang M.Q. and Wang J.J., ChIP-Array 2: integrating multiple omics data to construct gene regulatory networks, Nucleic Acids Research. 2015, 43(W1): W264-9.

Researcher : Zhang B

List of Research Outputs

Zhang B., HUA Y., Yu B., Lau C.Y., Cai J., Zheng S.Y., Yam W.C., Kao R.Y.T., Sze K.H., Zheng B., Yuen K.Y. and Huang J., Recombinant ESAT-6-Like Proteins Provoke Protective Immune Responses against Invasive Staphylococcus aureus Disease in a Murine Model, Infection and Immunity. 2015, 83: 339-345.

Researcher : Zhou Z

Project Title:	Understanding the regulation of MT1-MMP activity in tumorigenesis
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Matching Fund for NSFC Young Researcher Award
Start Date:	05/2006

Project Title:	Screening anti-ageing substances in small chemical library using premature ageing animals
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	09/2007

Project Title:	Ageing and longevity: biology and challenge
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Croucher Advanced Study Institute
Start Date:	02/2009

Project Title:	Stem Cells and the Key signaling Pathways in Bone Aging and Regeneration
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:	03/2011

Project Title:	Stem Cell Strategy for Nervous System Disorders
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	09/2012

Project Title:	MT1-MMP regulates neural stem cells self-renewal and differentiation via Notch signaling
Investigator(s):	Zhou Z, Osorio Da Silva LA
Department:	Biochemistry
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2013

Project Title:	MT1-MMP-mediated ADAM15 shedding in angiogenesis
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2013

Project Title:	Novel SIRT1 activator
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2013

Project Title:	Chromatin remodeling in laminopathy-based progeria
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2013

Project Title:	Interplay between ADAM15 and MT1-MMP in FGF2-induced angiogenesis
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2013

Project Title:	Regulation of Gli Signaling and Basal Cell Carcinoma by UHRF1
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2014

Project Title:	Regulation of heterochromatin remodeling in DNA repair and aging
Investigator(s):	Zhou Z, Hao Q, Chu IK
Department:	Biochemistry
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	02/2014

Project Title:	Outstanding Researcher Award 2013-14
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	12/2014

List of Research Outputs

GHOSH S. and Zhou Z., Regulation of SIRT6 Activities by the Lamins, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.

YANG X., Hu X. and Zhou Z., Novel Post Transcriptional Modification of UHRF1 and Its Biological Relevance, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

ZHANG S. and Zhou Z., Role of Membrane Type-I Matrix Metalloproteinase (MT1-MMP) in Mouse Intestinal Development, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.

Zhou Z., Croucher Senior Research Fellow 2015, Croucher Foundation. 2014.

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