DEPT OF ANAESTHESIOLOGY
| Researcher : Cai Y |
| Project Title: | Rap1 exacerbates myocardial ischemia/reperfusion injury through enhancing cell apoptosis and inflammatory response |
| Investigator(s): | Cai Y, Xia Z, Irwin MG |
| Department: | Anaesthesiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 08/2017 |
| Project Title: | Experimental Biology 2018; Rap1 exacerbates myocardial ischemia/reperfusion injury through enhancing cell apoptosis and inflammatory response |
| Investigator(s): | Cai Y |
| Department: | Anaesthesiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2018 |
| Completion Date: | 04/2018 |
| List of Research Outputs |
| Cai Y., Best Poster Award, American Society of Pharmacology & Experimental Therapeutics . 2018. |
| Cai Y., Kosuru R., Ye X., Irwin M.G. and Xia Z., Decoding telomere protein Rap1: its telomeric and nontelomeric functions and potential implications in diabetic cardiomyopathy, Cell Cycle. 2017, Aug 30. |
| Cai Y., Irwin M.G. and Xia Z., Rap1 exacerbates myocardial ischemia/reperfusion injury through enhancing cell apoptosis and inflammatory response, Experimental Biology 2018. 32. |
| Cai Y., Young Scientist Travel Award , American Society of Pharmacology & Experimental Therapeutics . 2018. |
| Ge L., Ma H., Cai Y., Pang L., Irwin M.G. and Xia Z., MicroRNA-181c-5p exacerbates apoptotic cell death in H9C2 cardiomyocytes during hypoxia/reoxygenation, Faseb Journal. 2018, 32. |
| He Y., Cai Y., YAN D., Zhang D., Chen C., Irwin M.G., Wang S. and Xia Z., MicroRNA-17-3p inhibits excessive post-hypoxic autophagy and attenuates H9C2 cardiomyocytes reoxygenation injury via PTEN-Akt-mTOR signaling, FASEB Journal. 2018, 32. |
| Kosuru R., Cai Y., KANDULA V., YAN D., WANG C., Zheng H., Li Y., Irwin M.G., Singh S. and Xia Z., AMPK Contributes to Cardioprotective Effects of Pterostilbene Against Myocardial Ischemia- Reperfusion Injury in Diabetic Rats by Suppressing Cardiac Oxidative Stress and Apoptosis, Cellular Physiology and Biochemistry. 2018, 46: 1381-1397. |
| YAN D., Cai Y., Luo J., Liu J., Irwin M.G. and Xia Z., Pharmacologic Inhibition of FOXO1 Improves Cardiac Function by Enhancing Glucose Metabolism and Attenuating Apoptosis in Type-1 Diabetic Rats, FASEB Jpurnal. 2018, 32. |
| Ying F., Cai Y., Tang E.H.C. and Xia Z., Deficiency of Prostaglandin E2 Receptor Subtype 4 Exacerbates Left Ventricular Remodeling and Myocardial Fibrosis in Diet-induced Mice, FASEB Journal. 2018, 32. |
| Ying F., Cai Y., Wong H.K., CHEN X., Huang B., Vanhoutte P.M.G.R., Xia Z., Xu A. and Tang E.H.C., EP4 emerges as a novel regulator of bile acid synthesis and its activation protects against hypercholesterolemia , BBA - Molecular and Cell Biology of Lipids. 2018. |
| Researcher : Chan TCW |
| List of Research Outputs |
| Chan W.K., Chan P.K., Chan T.C.W., Fu C.H.H., Chiu P.K.Y. and Yan C.H., CQI Project Award & Best Project Presentation Award, Hospital Authority. 2017. |
| Wong S.C.S., Chan T.C.W. and Cheung C.W., Spinal cord stimulation for chronic non-cancer pain: a review of current evidence and practice, Hong Kong Medical Journal. 2017, in press. |
| Researcher : Cheung CW |
| Project Title: | Cash donation to support service and clinical research (Pain Management) |
| Investigator(s): | Cheung CW, Irwin MG |
| Department: | Anaesthesiology |
| Source(s) of Funding: | Cash donation for supporting service and clinical research |
| Start Date: | 11/2013 |
| Project Title: | Central CXCL12/CXCR4 axis contributes to the induction of peripheral neuropathic pain |
| Investigator(s): | Cheung CW, Irwin MG, Wong SCS |
| Department: | Anaesthesiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2015 |
| Project Title: | Determining the role of histone deacetylase 2 (HDAC2) in the pathogenesis of chemotherapy-induced peripheral neuropathy (CIPN) |
| Investigator(s): | Cheung CW |
| Department: | Anaesthesiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2018 |
| List of Research Outputs |
| Cheung C.W., Speaker. World Congress 2016 lesson learnt from Hong Kong WCA and advice for Singapore 2024, College of Anesthesiologist, Singapore 11th Annual Refresher Course. 9th April 2017, Malaysia. 2018. |
| Lam W.L., Yeung W.F., Wong M.K., Cheung C.W., Chan K.K.L., Ngan H.Y.S., Wong C.K.H., Chen H. and Lao L., Combined electroacupuncture and auricular acupuncture for postoperative pain after abdominal surgery for gynecological diseases: study protocol for a randomized controlled trial, Trials. 2018, 19: 8. |
| Tai L.W., Sun L.T., Li H., GU P., Wong S.C.S., Chung S.K. and Cheung C.W., Supression of Pax2 Attenuates Allodynia and Hyperalgesia through ET-1-ETAR-NFAT5 Signaling in a Rat Model of Neuropathic Pain, Neuroscience. 2018, 384: 139-151. |
| Wong K., Cheung C.W. and Leung Y.M., The protective effect of eicosapentaenoic unusual mechanisms of Ca2+ release and Ca2+ influx in mouse cerebral cortical endothelial cells, International Academy of Cardiology Annual Scientific Sessions 2017, 22nd World Congress on Heart Disease. Vancouver, BC, Canada. 14 July to 16 July 2017. |
| Wong S.C.S., Choi S.W. and Cheung C.W., A comparison of chronic pain with and without neuropathic characteristics in a Hong Kong Chinese population: an analysis of pain related outcomes and patient help seeking behaviour, PLoS One. 2018, 2018. |
| Wong S.C.S., Qiu Q. and Cheung C.W., Segmental Spinal Myoclonus Complicating Lumbar Transforaminal Epidural Steroid Injection, Reg Anesth Pain Med. 2018, 43(5): 554-556. |
| Wong S.C.S., Chan T.C.W. and Cheung C.W., Spinal cord stimulation for chronic non-cancer pain: a review of current evidence and practice, Hong Kong Medical Journal. 2017, in press. |
| Researcher : Choi SW |
| List of Research Outputs |
| Choi S.W., Charlesworth M. and Wong G.T.C., A good pilot to navigate troubled waters, Anaesthesia. 2018, 73: 512-514. |
| Choi S.W. and Wong G.T.C., Before and after studies and historical controls. Is the proof in the pudding?, Anaesthesia. 2018, 73: 642-644. |
| Choi S.W. and Wong G.T.C., Big data, big problems: causation, confounders and cohorts, Anaesthesia. 2018, 73: 384-387. |
| Choi S.W., Leung F.K.L., Lau T.W. and Wong G.T.C., Impact of postoperative haemoglobin on length of stay post fractured hip repair in patients with standardised perioperative management, HIP International. 2018, E Pub. |
| Wong G.T.C., Choi S.W., Tran D.H.D., Kulkarni H. and Irwin M.G., An international survey evaluating factors influencing the use of total intravenous anaesthesia, Anaesthesia and Intensive Care. 2018, 46: 332-338. |
| Wong G.T.C., Choi S.W., Tran D.H.D., Kulkarni K. and Irwin M.G., An international survey evaluating factors influencing the use of total intravenous anaethesia, Anaesthesia and Intensive Care. 2018, 46(3): 332-338. |
| Wong G.T.C., Ang W.C., Wong C.L.T. and Choi S.W., Surgical Outcome Risk Tool (SORT) validation in hepatectomy, Anaesthesia. 2017, 72: 1287-1289. |
| Wong S.C.S., Choi S.W. and Cheung C.W., A comparison of chronic pain with and without neuropathic characteristics in a Hong Kong Chinese population: an analysis of pain related outcomes and patient help seeking behaviour, PLoS One. 2018, 2018. |
| Yuen V.M.Y., LI B.L., Cheuk D.K., Leung K.M.M., Hui T.W.C., Wong I.C., Lam W.W., Choi S.W. and Irwin M.G., A randomised controlled trial of oral chloral hydrate vs. intranasal dexmedetomidine before computerised tomography in children, Anaethesia. 2017, 25. |
| Researcher : GU P |
| List of Research Outputs |
| Tai L.W., Sun L.T., Li H., GU P., Wong S.C.S., Chung S.K. and Cheung C.W., Supression of Pax2 Attenuates Allodynia and Hyperalgesia through ET-1-ETAR-NFAT5 Signaling in a Rat Model of Neuropathic Pain, Neuroscience. 2018, 384: 139-151. |
| Researcher : Ge L |
| List of Research Outputs |
| Ge L., Ma H., Cai Y., Pang L., Irwin M.G. and Xia Z., MicroRNA-181c-5p exacerbates apoptotic cell death in H9C2 cardiomyocytes during hypoxia/reoxygenation, Faseb Journal. 2018, 32. |
| Researcher : Greenland KB |
| List of Research Outputs |
| Greenland K.B., Bradley W.P.L., van Zundert A. and Irwin M.G., Airway assessment/management paradigm - does a spectral or a binary approach fit better?, Anaesthesia. 2017, 72(8). |
| Greenland K.B. and Irwin M.G., Big data: breaking new ground in airway research, Anaesthesia. 2018, 73(6): 674-678. |
| Researcher : HUANG C |
| List of Research Outputs |
| HUANG C., Irwin M.G., Wong G.T.C. and Chang R.C.C., Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal model, Journal of Neuroinflammation. 2018, 15: 147. |
| Researcher : He Y |
| List of Research Outputs |
| He Y., Cai Y., YAN D., Zhang D., Chen C., Irwin M.G., Wang S. and Xia Z., MicroRNA-17-3p inhibits excessive post-hypoxic autophagy and attenuates H9C2 cardiomyocytes reoxygenation injury via PTEN-Akt-mTOR signaling, FASEB Journal. 2018, 32. |
| Researcher : Ho RHY |
| List of Research Outputs |
| Ho R.H.Y. and Irwin M.G., Anaesthesia for major spinal surgery, Anaesthesia and Intensive Care Medicine. 2018, 19(4): 159-163. |
| Researcher : Hui TWC |
| List of Research Outputs |
| Yuen V.M.Y., LI B.L., Cheuk D.K., Leung K.M.M., Hui T.W.C., Wong I.C., Lam W.W., Choi S.W. and Irwin M.G., A randomised controlled trial of oral chloral hydrate vs. intranasal dexmedetomidine before computerised tomography in children, Anaethesia. 2017, 25. |
| Researcher : Irwin MG |
| Project Title: | A comparative study of hydroxyethyl starch (130/0.4) and gelatin on the immune response in paediatric scoliosis surgery |
| Investigator(s): | Irwin MG, Wylie SJ |
| Department: | Anaesthesiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2009 |
| Project Title: | Radiofrequency therapy for chronic and cancer pain patient |
| Investigator(s): | Irwin MG, Cheung CW |
| Department: | Anaesthesiology |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 08/2010 |
| Project Title: | Role of Brg1 in Sevoflurane Postconditioning Cardioprotection in Diabetes and Its Interplay with STAT3 |
| Investigator(s): | Irwin MG, Xia Z, Vanhoutte PMGR, Wong GTC |
| Department: | Anaesthesiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2015 |
| Completion Date: | 03/2018 |
| Project Title: | Repressor activator protein 1 increases the susceptibility to myocardial ischemia/reperfusion injury in type 2 diabetic mice |
| Investigator(s): | Irwin MG, Vanhoutte PMGR, Wong GTC, Xia Z |
| Department: | Anaesthesiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2018 |
| List of Research Outputs |
| Cai Y., Kosuru R., Ye X., Irwin M.G. and Xia Z., Decoding telomere protein Rap1: its telomeric and nontelomeric functions and potential implications in diabetic cardiomyopathy, Cell Cycle. 2017, Aug 30. |
| Cai Y., Irwin M.G. and Xia Z., Rap1 exacerbates myocardial ischemia/reperfusion injury through enhancing cell apoptosis and inflammatory response, Experimental Biology 2018. 32. |
| Gan X., Xing D., Su G., Li S., Luo C., Irwin M.G., Xia Z., LI H. and Hei Z., Corrigendum to “Propofol Attenuates Small Intestinal Ischemia Reperfusion Injury through Inhibiting NADPH Oxidase Mediated Mast Cell Activation”, Oxidative Medicine and Cellular Longevity. 2017, 2017: 1-3. |
| Ge L., Ma H., Cai Y., Pang L., Irwin M.G. and Xia Z., MicroRNA-181c-5p exacerbates apoptotic cell death in H9C2 cardiomyocytes during hypoxia/reoxygenation, Faseb Journal. 2018, 32. |
| Greenland K.B., Bradley W.P.L., van Zundert A. and Irwin M.G., Airway assessment/management paradigm - does a spectral or a binary approach fit better?, Anaesthesia. 2017, 72(8). |
| Greenland K.B. and Irwin M.G., Big data: breaking new ground in airway research, Anaesthesia. 2018, 73(6): 674-678. |
| HUANG C., Irwin M.G., Wong G.T.C. and Chang R.C.C., Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal model, Journal of Neuroinflammation. 2018, 15: 147. |
| He Y., Cai Y., YAN D., Zhang D., Chen C., Irwin M.G., Wang S. and Xia Z., MicroRNA-17-3p inhibits excessive post-hypoxic autophagy and attenuates H9C2 cardiomyocytes reoxygenation injury via PTEN-Akt-mTOR signaling, FASEB Journal. 2018, 32. |
| Ho R.H.Y. and Irwin M.G., Anaesthesia for major spinal surgery, Anaesthesia and Intensive Care Medicine. 2018, 19(4): 159-163. |
| Irwin M.G., Annual Scientific Meeting, Korean Society of Anaethetists. 2017. |
| Irwin M.G., Ernest Henry Starling Lecture at the annual Evidence Based Perioperative Medicine in London, July , Australian and New Zealand College of Anaesthetists. 2017. |
| Irwin M.G., Peri-operative Medicine Congress (EBPOM), London, UK. 2017. |
| Jin S.Y., Huang J., Zhu H.J., Wu H., XU S.H., Irwin M.G., HE S.F. and Zhang Y., Remifentanil preconditioning confers cardioprotection via c-Jun NH2-terminal kinases and extracellular signal regulated kinases pathways in ex-vivo failing rat heart, European Journal of Pharmacology. 2018, 5(828): 1-8. |
| Kong K.F.V., Jian C.J., Ji R. and Irwin M.G., Management of an incidental finding of right internal jugular vein agenesis, Hong Kong Medical Journal. 2017, 23(4): 414-415. |
| Kosuru R., Cai Y., KANDULA V., YAN D., WANG C., Zheng H., Li Y., Irwin M.G., Singh S. and Xia Z., AMPK Contributes to Cardioprotective Effects of Pterostilbene Against Myocardial Ischemia- Reperfusion Injury in Diabetic Rats by Suppressing Cardiac Oxidative Stress and Apoptosis, Cellular Physiology and Biochemistry. 2018, 46: 1381-1397. |
| Kwok D.H.Y. and Irwin M.G., Preoperative assessment of the orthopaedic patient, Anaesthesia and Intensive Care Medicine. 2018, 01/2018: 151-154. |
| LI H., Irwin M.G. and Xia Z., Hyperglycemia-induced Protein Kinase Cβ2 Activation Causes Diastolic Cardiac Dysfunction by Disrupting Brg1-mediated Suppression of RIP3 in Diabetic Rats, FASEB Journal. 2018, 31. |
| Lau Y.C. and Irwin M.G., Anaesthesia for joint replacement surgery, Anaethesia and Intensive Care Medicine. 2018, 19(4): 171-174. |
| Liu Y., Paterson M., Baumgardt S., Irwin M.G., Xia Z., Bosnjak Z. and Ge Z., VEGF regulation of Enos phosphorylation is involved in isoflurane cardiac preconditioning, Cardiovascular. 2018, 21. |
| Mu J., Jiang T., Xu X.B., Yuen V.M.Y. and Irwin M.G., Comparison of target-controlled infusion and manual infusion for Propofol anaesthesia in children, British Journal of Anaesthesia. 2018, 120(5): 1049-1055. |
| Mu J.J., Jiang T., Deng L.P., Choi S.W., Irwin M.G. and Yuen V.M.Y., A comparison of two techniques for induction of anaesthesia with target-controlled infusion of propofol, Anaesthesia. 2018, 6 (29). |
| Pandit J.J. and Irwin M.G., Airway management in critical illness: practice implications of new difficult airway society guidelines, Anaesthesia. 2018, 73(5): 544-548. |
| Pandit J.J. and Irwin M.G., Difficult airway society guidelines on the airway management of critically ill patients. A reply, Anaesthesia . 2018, 73(8): 1036-1037. |
| Sheng Y., Standing J.F., Kwok P.C.L., Leung A.S., Wong I.C.K. and Irwin M.G., Pharmacokinetic and pharmacodynamic study of intranasal and intravenous dexmedetomidine, British Journal of Anaesthesia. 2018, 120(5): 960-968. |
| Smith A.S. and Irwin M.G., Researching research, Anaesthesia. 2018, 73(6): 668-671. |
| Wong G.T.C., Choi S.W., Tran D.H.D., Kulkarni H. and Irwin M.G., An international survey evaluating factors influencing the use of total intravenous anaesthesia, Anaesthesia and Intensive Care. 2018, 46: 332-338. |
| Wong G.T.C., Choi S.W., Tran D.H.D., Kulkarni K. and Irwin M.G., An international survey evaluating factors influencing the use of total intravenous anaethesia, Anaesthesia and Intensive Care. 2018, 46(3): 332-338. |
| Wong S. and Irwin M.G., Procedures under tourniquet, Anaethesia and Intensive Care Medicine. 2018, 19(4): 155-158. |
| Wong S.C.S. and Irwin M.G., Anaesthesia and minimally invasive surgery, Anaesthesia & Intensive Care Medicine. 2017, 19(1): 11-15. |
| Wong S.C.S. and Irwin M.G., Anaesthesia for fractured neck of femur, Anaesthesia & Intensive Care Medicine. 2018, 19: 175-178. |
| YAN D., Cai Y., Luo J., Liu J., Irwin M.G. and Xia Z., Pharmacologic Inhibition of FOXO1 Improves Cardiac Function by Enhancing Glucose Metabolism and Attenuating Apoptosis in Type-1 Diabetic Rats, FASEB Jpurnal. 2018, 32. |
| YE X.D., HE Y., Wang S., Wong G.T.C., Irwin M.G. and Xia Z., Heart-type fatty acid binding protein (H-FABP) as a biomarker for acute myocardial injury and long-term post-ischemic prognosis, Acta Pharmacologica Sinica. 2018, 39(7): 1155-1163. |
| Yuen V.M.Y., LI B.L., Cheuk D.K., Leung K.M.M., Hui T.W.C., Wong I.C., Lam W.W., Choi S.W. and Irwin M.G., A randomised controlled trial of oral chloral hydrate vs. intranasal dexmedetomidine before computerised tomography in children, Anaethesia. 2017, 25. |
| Researcher : KANDULA V |
| List of Research Outputs |
| Kosuru R., Cai Y., KANDULA V., YAN D., WANG C., Zheng H., Li Y., Irwin M.G., Singh S. and Xia Z., AMPK Contributes to Cardioprotective Effects of Pterostilbene Against Myocardial Ischemia- Reperfusion Injury in Diabetic Rats by Suppressing Cardiac Oxidative Stress and Apoptosis, Cellular Physiology and Biochemistry. 2018, 46: 1381-1397. |
| Kosuru R., KANDULA V., Rai U., Prakash S., Xia Z. and Singh S., Pterostilbene Decreases Cardiac Oxidative Stress and Inflammation via Activation of AMPK/Nrf2/HO-1 Pathway in Fructose-Fed Diabetic Rats, Cardiovascular Drugs and Therapy. 2018, 32: 147-163. |
| Researcher : Kong KFV |
| List of Research Outputs |
| Kong K.F.V., Jian C.J., Ji R. and Irwin M.G., Management of an incidental finding of right internal jugular vein agenesis, Hong Kong Medical Journal. 2017, 23(4): 414-415. |
| Researcher : Kwok DHY |
| List of Research Outputs |
| Kwok D.H.Y. and Irwin M.G., Preoperative assessment of the orthopaedic patient, Anaesthesia and Intensive Care Medicine. 2018, 01/2018: 151-154. |
| Researcher : LI H |
| List of Research Outputs |
| Deng F., Wang S., Zhang L., XIE X., Cai S., LI H., Xie G., Miao H., Yang C., Liu X. and Xia Z., Propofol Through Upregulating Caveolin-3 Attenuates Post-Hypoxic Mitochondrial Damage and Cell Death in H9C2 Cardiomyocytes During Hyperglycemia, Cellular Physiology and Biochemistry. 2017, 44: 279-292. |
| Gan X., Xing D., Su G., Li S., Luo C., Irwin M.G., Xia Z., LI H. and Hei Z., Corrigendum to “Propofol Attenuates Small Intestinal Ischemia Reperfusion Injury through Inhibiting NADPH Oxidase Mediated Mast Cell Activation”, Oxidative Medicine and Cellular Longevity. 2017, 2017: 1-3. |
| Gao S., Zhan L., Yang Z., Shi R., Li H., Xia Z., Yuan S., Wu Q.P., Wang T. and Yao S., Remote Limb Ischaemic Postconditioning Protects Against Myocardial Ischaemia/Reperfusion Injury in Mice: Activation of JAK/STAT3-Mediated Nrf2-Antioxidant Signalling., Cell Physiol Biochem. . 2017, 43(3): 1140-1151. |
| LI H., Irwin M.G. and Xia Z., Hyperglycemia-induced Protein Kinase Cβ2 Activation Causes Diastolic Cardiac Dysfunction by Disrupting Brg1-mediated Suppression of RIP3 in Diabetic Rats, FASEB Journal. 2018, 31. |
| Li H., Xia Z., Chen Y., Qi D. and Zheng H., Mechanism and Therapies of Oxidative Stress-Mediated Cell Death in Ischemia Reperfusion Injury, Oxidative Medicine and Cellular Longevity. 2018, 2018: 1-2. |
| Tai L.W., Sun L.T., Li H., GU P., Wong S.C.S., Chung S.K. and Cheung C.W., Supression of Pax2 Attenuates Allodynia and Hyperalgesia through ET-1-ETAR-NFAT5 Signaling in a Rat Model of Neuropathic Pain, Neuroscience. 2018, 384: 139-151. |
| Yao W., Li H., Han X., Chen C., Zhang Y., Tai W.L., Xia Z. and Hei Z., MG53 anchored by dysferlin to cell membrane reduces hepatocyte apoptosis which induced by ischaemia/reperfusion injury in vivo and in vitro., J Cell Mol Med. 2017, (10): 2503-2513. |
| Yao W., Li H., Luo G., Li X., Chen C., Yuan D., Chi X., Xia Z. and Hei Z., SERPINB1 ameliorates acute lung injury in liver transplantation through ERK1/2-mediated STAT3-dependent HO-1 induction., Free Radic Biol Med. 2017, 108: 542-553. |
| Researcher : Leung KMM |
| List of Research Outputs |
| Yuen V.M.Y., LI B.L., Cheuk D.K., Leung K.M.M., Hui T.W.C., Wong I.C., Lam W.W., Choi S.W. and Irwin M.G., A randomised controlled trial of oral chloral hydrate vs. intranasal dexmedetomidine before computerised tomography in children, Anaethesia. 2017, 25. |
| Researcher : Li H |
| List of Research Outputs |
| Deng F., Wang S., Zhang L., XIE X., Cai S., LI H., Xie G., Miao H., Yang C., Liu X. and Xia Z., Propofol Through Upregulating Caveolin-3 Attenuates Post-Hypoxic Mitochondrial Damage and Cell Death in H9C2 Cardiomyocytes During Hyperglycemia, Cellular Physiology and Biochemistry. 2017, 44: 279-292. |
| Gan X., Xing D., Su G., Li S., Luo C., Irwin M.G., Xia Z., LI H. and Hei Z., Corrigendum to “Propofol Attenuates Small Intestinal Ischemia Reperfusion Injury through Inhibiting NADPH Oxidase Mediated Mast Cell Activation”, Oxidative Medicine and Cellular Longevity. 2017, 2017: 1-3. |
| Gao S., Zhan L., Yang Z., Shi R., Li H., Xia Z., Yuan S., Wu Q.P., Wang T. and Yao S., Remote Limb Ischaemic Postconditioning Protects Against Myocardial Ischaemia/Reperfusion Injury in Mice: Activation of JAK/STAT3-Mediated Nrf2-Antioxidant Signalling., Cell Physiol Biochem. . 2017, 43(3): 1140-1151. |
| LI H., Irwin M.G. and Xia Z., Hyperglycemia-induced Protein Kinase Cβ2 Activation Causes Diastolic Cardiac Dysfunction by Disrupting Brg1-mediated Suppression of RIP3 in Diabetic Rats, FASEB Journal. 2018, 31. |
| Li H., Xia Z., Chen Y., Qi D. and Zheng H., Mechanism and Therapies of Oxidative Stress-Mediated Cell Death in Ischemia Reperfusion Injury, Oxidative Medicine and Cellular Longevity. 2018, 2018: 1-2. |
| Tai L.W., Sun L.T., Li H., GU P., Wong S.C.S., Chung S.K. and Cheung C.W., Supression of Pax2 Attenuates Allodynia and Hyperalgesia through ET-1-ETAR-NFAT5 Signaling in a Rat Model of Neuropathic Pain, Neuroscience. 2018, 384: 139-151. |
| Yao W., Li H., Han X., Chen C., Zhang Y., Tai W.L., Xia Z. and Hei Z., MG53 anchored by dysferlin to cell membrane reduces hepatocyte apoptosis which induced by ischaemia/reperfusion injury in vivo and in vitro., J Cell Mol Med. 2017, (10): 2503-2513. |
| Yao W., Li H., Luo G., Li X., Chen C., Yuan D., Chi X., Xia Z. and Hei Z., SERPINB1 ameliorates acute lung injury in liver transplantation through ERK1/2-mediated STAT3-dependent HO-1 induction., Free Radic Biol Med. 2017, 108: 542-553. |
| Researcher : Liu J |
| List of Research Outputs |
| Liu J., YAN D., XIE X. and Xia Z., FOXO1 Couples Reactive Oxygen Species in Diabetic Atherosclerosis, FASEB Journal. 2018, 32. |
| YAN D., Cai Y., Luo J., Liu J., Irwin M.G. and Xia Z., Pharmacologic Inhibition of FOXO1 Improves Cardiac Function by Enhancing Glucose Metabolism and Attenuating Apoptosis in Type-1 Diabetic Rats, FASEB Jpurnal. 2018, 32. |
| Researcher : Luo J |
| List of Research Outputs |
| YAN D., Cai Y., Luo J., Liu J., Irwin M.G. and Xia Z., Pharmacologic Inhibition of FOXO1 Improves Cardiac Function by Enhancing Glucose Metabolism and Attenuating Apoptosis in Type-1 Diabetic Rats, FASEB Jpurnal. 2018, 32. |
| Researcher : Ng JKF |
| Project Title: | The role of endothelial arginine, arginase and nitric oxide on dexmedetomidine induced vascular contraction |
| Investigator(s): | Ng KFJ, Leung SWS |
| Department: | Anaesthesiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2012 |
| List of Research Outputs |
| Researcher : Ng KFJ |
| Project Title: | The role of endothelial arginine, arginase and nitric oxide on dexmedetomidine induced vascular contraction |
| Investigator(s): | Ng KFJ, Leung SWS |
| Department: | Anaesthesiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2012 |
| List of Research Outputs |
| Wong E.S.W., Man R.Y.K., Ng K.F.J., Leung S.W.S. and Vanhoutte P.M.G.R., L-arginine and Arginase Products Potentiate Dexmedetomidine-induced Contractions in the Rat Aorta, Anesthesiology. 2018, 128: 564-573. |
| Researcher : Pang L |
| List of Research Outputs |
| Ge L., Ma H., Cai Y., Pang L., Irwin M.G. and Xia Z., MicroRNA-181c-5p exacerbates apoptotic cell death in H9C2 cardiomyocytes during hypoxia/reoxygenation, Faseb Journal. 2018, 32. |
| Researcher : Qiu Q |
| List of Research Outputs |
| Wong S.C.S., Qiu Q. and Cheung C.W., Segmental Spinal Myoclonus Complicating Lumbar Transforaminal Epidural Steroid Injection, Reg Anesth Pain Med. 2018, 43(5): 554-556. |
| Researcher : Rodrigo MRC |
| Project Title: | 4th South Asian Confederation of Anaesthesiologists Congress Anaesthesia for Orthognathic Surgery |
| Investigator(s): | Rodrigo MRC |
| Department: | Anaesthesiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/1999 |
| Project Title: | The Association of Dental Anaesthetists 25th Anniversary Summer Scientific Meeting Patient Controlled Sedation with Propolfol |
| Investigator(s): | Rodrigo MRC |
| Department: | Anaesthesiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2002 |
| Researcher : Sun LT |
| List of Research Outputs |
| Tai L.W., Sun L.T., Li H., GU P., Wong S.C.S., Chung S.K. and Cheung C.W., Supression of Pax2 Attenuates Allodynia and Hyperalgesia through ET-1-ETAR-NFAT5 Signaling in a Rat Model of Neuropathic Pain, Neuroscience. 2018, 384: 139-151. |
| Researcher : Tai WL |
| List of Research Outputs |
| Yao W., Li H., Han X., Chen C., Zhang Y., Tai W.L., Xia Z. and Hei Z., MG53 anchored by dysferlin to cell membrane reduces hepatocyte apoptosis which induced by ischaemia/reperfusion injury in vivo and in vitro., J Cell Mol Med. 2017, (10): 2503-2513. |
| Researcher : Tran DHD |
| List of Research Outputs |
| Wong G.T.C., Choi S.W., Tran D.H.D., Kulkarni H. and Irwin M.G., An international survey evaluating factors influencing the use of total intravenous anaesthesia, Anaesthesia and Intensive Care. 2018, 46: 332-338. |
| Wong G.T.C., Choi S.W., Tran D.H.D., Kulkarni K. and Irwin M.G., An international survey evaluating factors influencing the use of total intravenous anaethesia, Anaesthesia and Intensive Care. 2018, 46(3): 332-338. |
| Researcher : WANG C |
| List of Research Outputs |
| Kosuru R., Cai Y., KANDULA V., YAN D., WANG C., Zheng H., Li Y., Irwin M.G., Singh S. and Xia Z., AMPK Contributes to Cardioprotective Effects of Pterostilbene Against Myocardial Ischemia- Reperfusion Injury in Diabetic Rats by Suppressing Cardiac Oxidative Stress and Apoptosis, Cellular Physiology and Biochemistry. 2018, 46: 1381-1397. |
| Researcher : Wong GTC |
| Project Title: | The cardiac preconditioning effect of surgery patients |
| Investigator(s): | Wong GTC, Irwin MG, Hiong YT, Das SR |
| Department: | Anaesthesiology |
| Source(s) of Funding: | Queen Mary Hospital Charitable Trust - Training and Research Assistance Scheme |
| Start Date: | 10/2007 |
| Project Title: | The impact of preoperative and postoperative haemoglobin level on rehabilitation duration in fracture hip patients |
| Investigator(s): | Wong GTC, Leung FKL |
| Department: | Anaesthesiology |
| Source(s) of Funding: | AOTrauma |
| Start Date: | 09/2014 |
| Project Title: | The role of surgery induced type 1 interferon on blood brain barrier dysfunction and postoperative cognitive dysfunction |
| Investigator(s): | Wong GTC, Chang RCC |
| Department: | Anaesthesiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| List of Research Outputs |
| Chan L.K., Ganotice F.J.A., Wong F.K.Y., Lau W.C.S., Bridges S.M., Chan C.H.Y., Chan N.K., Chan W.L.P., Chen H., Chen J.Y., Chu K.P.J., Ho C.C., Ho J.M.C., Lam T.P., Lam S.F., Li Q., Shen J., Tanner J.A., Tso W.Y.W., Wong A.K.C., Wong G.T.C., Wong J.Y.H., Wong N.S., Worsley A.J., Yu L.K. and Yum T.P., Implementation of an interprofessional team-based learning program involving seven undergraduate health and social care programs from two universities, and students’ evaluation of their readiness for interprofessional learning, BMC Medical Education. 2017, 17. |
| Choi S.W., Charlesworth M. and Wong G.T.C., A good pilot to navigate troubled waters, Anaesthesia. 2018, 73: 512-514. |
| Choi S.W. and Wong G.T.C., Before and after studies and historical controls. Is the proof in the pudding?, Anaesthesia. 2018, 73: 642-644. |
| Choi S.W. and Wong G.T.C., Big data, big problems: causation, confounders and cohorts, Anaesthesia. 2018, 73: 384-387. |
| Choi S.W., Leung F.K.L., Lau T.W. and Wong G.T.C., Impact of postoperative haemoglobin on length of stay post fractured hip repair in patients with standardised perioperative management, HIP International. 2018, E Pub. |
| Choi S.W. and Wong G.T.C., The art and science of statistical predictions: does a picture need a thousand words?, Anaesthesia. 2018, 73: 784-787. |
| HUANG C., Irwin M.G., Wong G.T.C. and Chang R.C.C., Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal model, Journal of Neuroinflammation. 2018, 15: 147. |
| Hou Y.Y., Li Y., He S.F., Song J., Yu D.X., Wong G.T.C. and Zhang Y., Effects of differential-phase remote ischemic preconditioning intervention in laparoscopic partial nephrectomy: A single blinded, randomized controlled trial in a parallel group design, Journal of Clinical Anesthesia. 2017, 41: 21-28. |
| Lu Y., Dai W.C., Zong Z., Xiao Y., Wu D.I., Liu X. and Wong G.T.C., Bronchial Blocker Versus Left Double-Lumen Endotracheal Tube for One-Lung Ventilation in Right Video-Assisted Thoracoscopic Surgery, Journal of Cardiothoracic and Vascular Anesthesia. 2017. |
| Wong G.T.C., "ERASURE: Early Recovery After Surgery for the Elderly ... A Little Respect?, Annual Scientific Meeting in Anaesthesiology 2017 Hong Kong College of Anaesthesiologists. 2017. |
| Wong G.T.C., Choi S.W., Tran D.H.D., Kulkarni H. and Irwin M.G., An international survey evaluating factors influencing the use of total intravenous anaesthesia, Anaesthesia and Intensive Care. 2018, 46: 332-338. |
| Wong G.T.C., Choi S.W., Tran D.H.D., Kulkarni K. and Irwin M.G., An international survey evaluating factors influencing the use of total intravenous anaethesia, Anaesthesia and Intensive Care. 2018, 46(3): 332-338. |
| Wong G.T.C., Editorial Board Member Korean Journal of Anaesthesia, 2017. |
| Wong G.T.C., Internal Examiner of PhD thesis titled "Atrio-ventricular conduction block: from disease models to novel therapeutic strategies", 2017. |
| Wong G.T.C., Monitoring the Brain, 2017 Philippine Society of Cardiothoracic Anesthesiologists Yearend Annual Conference "Revisiting Useful Hemodynamic Concepts in Monitoring the Criticallt Ill Patients. 2017. |
| Wong G.T.C., Patient emergence – statistical questions, Anaesthesia. 2018, 73: 130-130. |
| Wong G.T.C., Reviewer for manuscript number SREP-17-49802 for Nature Scientific Reports, 2018. |
| Wong G.T.C., Reviewer of Manuscript AJADD 17 153 for American Journal of Alzheimers Disease & Other Dementias, 2017. |
| Wong G.T.C., Ang W.C., Wong C.L.T. and Choi S.W., Surgical Outcome Risk Tool (SORT) validation in hepatectomy, Anaesthesia. 2017, 72: 1287-1289. |
| YE X.D., HE Y., Wang S., Wong G.T.C., Irwin M.G. and Xia Z., Heart-type fatty acid binding protein (H-FABP) as a biomarker for acute myocardial injury and long-term post-ischemic prognosis, Acta Pharmacologica Sinica. 2018, 39(7): 1155-1163. |
| Yuen V.M.Y., Wong C.H.P., Wong S.C.S. and Wong G.T.C., Rescue oxygenation in small infants, Anaesthesia. 2017, 72: 1564-1565. |
| Researcher : Wong K |
| List of Research Outputs |
| Wong K., Cheung C.W. and Leung Y.M., The protective effect of eicosapentaenoic unusual mechanisms of Ca2+ release and Ca2+ influx in mouse cerebral cortical endothelial cells, International Academy of Cardiology Annual Scientific Sessions 2017, 22nd World Congress on Heart Disease. Vancouver, BC, Canada. 14 July to 16 July 2017. |
| Researcher : Wong S |
| List of Research Outputs |
| Wong S. and Irwin M.G., Procedures under tourniquet, Anaethesia and Intensive Care Medicine. 2018, 19(4): 155-158. |
| Researcher : Wong SCS |
| Project Title: | Intrathecal administration of RhoA, ROCK and ERK inhibitors reduces thermal and inflammatory hyperalgesia in DLC2-/- (knockout) mice |
| Investigator(s): | Wong SCS, Chung SK, Cheung CW |
| Department: | Anaesthesiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 04/2015 |
| Project Title: | The role of Deleted in Liver Cancer 2 (DLC2) with RhoGAP activity in a mice model of Chronic Regional Pain Syndrome type 1 |
| Investigator(s): | Wong SCS, Chung SK, Cheung CW, Xia Z |
| Department: | Anaesthesiology |
| Source(s) of Funding: | Seed Fund for Basic Research for Resubmission of GRF/ECS Proposals |
| Start Date: | 07/2017 |
| Completion Date: | 11/2017 |
| List of Research Outputs |
| Tai L.W., Sun L.T., Li H., GU P., Wong S.C.S., Chung S.K. and Cheung C.W., Supression of Pax2 Attenuates Allodynia and Hyperalgesia through ET-1-ETAR-NFAT5 Signaling in a Rat Model of Neuropathic Pain, Neuroscience. 2018, 384: 139-151. |
| Wong S.C.S., Choi S.W. and Cheung C.W., A comparison of chronic pain with and without neuropathic characteristics in a Hong Kong Chinese population: an analysis of pain related outcomes and patient help seeking behaviour, PLoS One. 2018, 2018. |
| Wong S.C.S. and Irwin M.G., Anaesthesia and minimally invasive surgery, Anaesthesia & Intensive Care Medicine. 2017, 19(1): 11-15. |
| Wong S.C.S. and Irwin M.G., Anaesthesia for fractured neck of femur, Anaesthesia & Intensive Care Medicine. 2018, 19: 175-178. |
| Wong S.C.S., More than mortality and morbidity- Patient reported outcome measures, 2nd Hong Kong Evidence Based Perioperative Medicine Symposium. 2018. |
| Wong S.C.S., Oral opioids for acute postoperative pain, Guangdong Annual Medical Association of Anesthesiology annual conference. 2018. |
| Wong S.C.S., Pharmacological drugs for extubation, International Summit Forum on Airway and Respiratory Management. 2018. |
| Wong S.C.S., Qiu Q. and Cheung C.W., Segmental Spinal Myoclonus Complicating Lumbar Transforaminal Epidural Steroid Injection, Reg Anesth Pain Med. 2018, 43(5): 554-556. |
| Wong S.C.S., Chan T.C.W. and Cheung C.W., Spinal cord stimulation for chronic non-cancer pain: a review of current evidence and practice, Hong Kong Medical Journal. 2017, in press. |
| Yuen V.M.Y., Wong C.H.P., Wong S.C.S. and Wong G.T.C., Rescue oxygenation in small infants, Anaesthesia. 2017, 72: 1564-1565. |
| Researcher : Wong TM |
| Project Title: | First Asia-Pacific Opioid Symposium Cardioprotective Effects of K-Opioids |
| Investigator(s): | Wong TM |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2000 |
| Project Title: | Outstanding Research Student Supervisor Award 2001-2002 |
| Investigator(s): | Wong TM |
| Department: | Anaesthesiology |
| Source(s) of Funding: | Outstanding Research Student Supervisor Award |
| Start Date: | 06/2002 |
| Project Title: | XVIII World Congress International Society for Heart Research in Conjunction with 52nd Annual Scientific Meeting of the Cardiac Society of Australia & New Zealand Delayed Cardioprotection of Kappa Opioid Receptor Stimulation in Normal and Diabetic Rats - Roles of Heat Shock Protein 70 and Intracellular Ca2+ |
| Investigator(s): | Wong TM |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2004 |
| Project Title: | CSANZ 2006 Annual Scientific Meeting Heat Shock Protein 70, Calcium Regulation and Cardiac Survival |
| Investigator(s): | Wong TM |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2006 |
| Researcher : XIE X |
| List of Research Outputs |
| Chen X., Wang Y., XIE X., Chen H., Zhu Q., Ge Z., Wei H., Deng J., Xia Z. and Lian Q., Heme Oxygenase-1 Reduces Sepsis-Induced Endoplasmic Reticulum Stress and Acute Lung Injury, Mediators of Inflammation. 2018, 2018: 1-10. |
| Deng F., Wang S., Zhang L., XIE X., Cai S., LI H., Xie G., Miao H., Yang C., Liu X. and Xia Z., Propofol Through Upregulating Caveolin-3 Attenuates Post-Hypoxic Mitochondrial Damage and Cell Death in H9C2 Cardiomyocytes During Hyperglycemia, Cellular Physiology and Biochemistry. 2017, 44: 279-292. |
| Liu J., YAN D., XIE X. and Xia Z., FOXO1 Couples Reactive Oxygen Species in Diabetic Atherosclerosis, FASEB Journal. 2018, 32. |
| Researcher : Xia Z |
| Project Title: | Nitrate tolerance compromises propofol protection of the endothelium against inflammation: The role of PKC-beta2 and NADPH oxidase interaction |
| Investigator(s): | Xia Z |
| Department: | Anaesthesiology |
| Source(s) of Funding: | SCA Research Starter and MidCareer Grants |
| Start Date: | 07/2008 |
| Project Title: | The role of FoxO1 in diabetic heart susceptibility to ischemia/reperfusion injury and sensitivity to ischemic postconditioning and its interplay with adiponectin |
| Investigator(s): | Xia Z, Vanhoutte PMGR, Xu A, Irwin MG |
| Department: | Anaesthesiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2014 |
| Completion Date: | 09/2017 |
| Project Title: | Experimental Biology 2015; Dexmedetomidine enhances cerebral cortex GIRK1 protein expression and attenuates Acute Postoperative Pain in rats. |
| Investigator(s): | Xia Z |
| Department: | Anaesthesiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2015 |
| Project Title: | Sevoflurance cardiopulmonary protection and mechanism |
| Investigator(s): | Xia Z |
| Department: | Anaesthesiology |
| Source(s) of Funding: | The First Hospital of Jilin University |
| Start Date: | 08/2015 |
| Project Title: | PKCß2 over-activation reduces cardiac tolerance to ischemia-reperfusion injury in diabetic rodents by downregulating caveolin-3 and modulating cardiomyocyte autophagy |
| Investigator(s): | Xia Z, Xu A, Vanhoutte PMGR, Wang JJ, Irwin MG |
| Department: | Anaesthesiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2015 |
| Project Title: | PKCε over-activation by down-regulating caveolin-3 compromises adiponectin-mediated ischemic postconditioning cardioprotection in diabetes |
| Investigator(s): | Xia Z, Irwin MG, Vanhoutte PMGR, Xu A |
| Department: | Anaesthesiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2016 |
| Completion Date: | 07/2018 |
| Project Title: | PKC-ϵ facilitates adiponectin to restore diabetic heart responsiveness to ischemic postconditioning: The importance of PKC-ϵ/Cav3 association. |
| Investigator(s): | Xia Z, Vanhoutte PMGR, Xu A, Irwin MG |
| Department: | Anaesthesiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2017 |
| Project Title: | Brg1 by down-regulating lncCNIF-mediated necroptosis restores sevoflurane postconditioning cardioprotection in diabetes |
| Investigator(s): | Xia Z, Xu A, Irwin MG, Li H |
| Department: | Anaesthesiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2017 |
| Project Title: | 2017 年中国研究型医院学会麻醉专业委员会学术年会; The Clinical Application of Remote Ischemic Preconditioning and Postconditioning in Cardiac Protection: The Challenges and Promises. |
| Investigator(s): | Xia Z |
| Department: | Anaesthesiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2017 |
| Completion Date: | 07/2017 |
| Project Title: | Experimental Biology; MicroRNA-181c-5p exacerbates apoptotic cell death in H9C2 cardiomyocytes during hypoxia/reoxygenation |
| Investigator(s): | Xia Z |
| Department: | Anaesthesiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2018 |
| Completion Date: | 04/2018 |
| Project Title: | Repressor activator protein 1 protects against mitochondrial function and ischemia/reperfusion injury in aging heart via PGC1α signaling activation |
| Investigator(s): | Xia Z, Irwin MG, Wong GTC, Cai Y, Xu A |
| Department: | Anaesthesiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2018 |
| List of Research Outputs |
| CHENG Y., Feng Y., Xia Z., Li X.C. and Rong J., ω-Alkynyl arachidonic acid promotes anti-inflammatory macrophage M2 polarization against acute myocardial infarction via regulating the cross-talk between PKM2, HIF-1α and iNOS, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2017, 1862: 1595-1605. |
| Cai Y., Kosuru R., Ye X., Irwin M.G. and Xia Z., Decoding telomere protein Rap1: its telomeric and nontelomeric functions and potential implications in diabetic cardiomyopathy, Cell Cycle. 2017, Aug 30. |
| Cai Y., Irwin M.G. and Xia Z., Rap1 exacerbates myocardial ischemia/reperfusion injury through enhancing cell apoptosis and inflammatory response, Experimental Biology 2018. 32. |
| Chang L., Ye F., Luo Q., Wang Z., Wang Y., Xia Z. and Shu H., Effects of three forms of local anesthesia on perioperative fentanyl-induced hyperalgesia, BioScience Trends. 2018, 12: 177-184. |
| Chen X., Wang Y., XIE X., Chen H., Zhu Q., Ge Z., Wei H., Deng J., Xia Z. and Lian Q., Heme Oxygenase-1 Reduces Sepsis-Induced Endoplasmic Reticulum Stress and Acute Lung Injury, Mediators of Inflammation. 2018, 2018: 1-10. |
| Deng F., Wang S., Zhang L., XIE X., Cai S., LI H., Xie G., Miao H., Yang C., Liu X. and Xia Z., Propofol Through Upregulating Caveolin-3 Attenuates Post-Hypoxic Mitochondrial Damage and Cell Death in H9C2 Cardiomyocytes During Hyperglycemia, Cellular Physiology and Biochemistry. 2017, 44: 279-292. |
| Gan X., Xing D., Su G., Li S., Luo C., Irwin M.G., Xia Z., LI H. and Hei Z., Corrigendum to “Propofol Attenuates Small Intestinal Ischemia Reperfusion Injury through Inhibiting NADPH Oxidase Mediated Mast Cell Activation”, Oxidative Medicine and Cellular Longevity. 2017, 2017: 1-3. |
| Gao S., Zhan L., Yang Z., Shi R., Li H., Xia Z., Yuan S., Wu Q.P., Wang T. and Yao S., Remote Limb Ischaemic Postconditioning Protects Against Myocardial Ischaemia/Reperfusion Injury in Mice: Activation of JAK/STAT3-Mediated Nrf2-Antioxidant Signalling., Cell Physiol Biochem. . 2017, 43(3): 1140-1151. |
| Ge L., Ma H., Cai Y., Pang L., Irwin M.G. and Xia Z., MicroRNA-181c-5p exacerbates apoptotic cell death in H9C2 cardiomyocytes during hypoxia/reoxygenation, Faseb Journal. 2018, 32. |
| He Y., Cai Y., YAN D., Zhang D., Chen C., Irwin M.G., Wang S. and Xia Z., MicroRNA-17-3p inhibits excessive post-hypoxic autophagy and attenuates H9C2 cardiomyocytes reoxygenation injury via PTEN-Akt-mTOR signaling, FASEB Journal. 2018, 32. |
| Kosuru R., Cai Y., KANDULA V., YAN D., WANG C., Zheng H., Li Y., Irwin M.G., Singh S. and Xia Z., AMPK Contributes to Cardioprotective Effects of Pterostilbene Against Myocardial Ischemia- Reperfusion Injury in Diabetic Rats by Suppressing Cardiac Oxidative Stress and Apoptosis, Cellular Physiology and Biochemistry. 2018, 46: 1381-1397. |
| Kosuru R., KANDULA V., Rai U., Prakash S., Xia Z. and Singh S., Pterostilbene Decreases Cardiac Oxidative Stress and Inflammation via Activation of AMPK/Nrf2/HO-1 Pathway in Fructose-Fed Diabetic Rats, Cardiovascular Drugs and Therapy. 2018, 32: 147-163. |
| LI H., Irwin M.G. and Xia Z., Hyperglycemia-induced Protein Kinase Cβ2 Activation Causes Diastolic Cardiac Dysfunction by Disrupting Brg1-mediated Suppression of RIP3 in Diabetic Rats, FASEB Journal. 2018, 31. |
| Li H., Xia Z., Chen Y., Qi D. and Zheng H., Mechanism and Therapies of Oxidative Stress-Mediated Cell Death in Ischemia Reperfusion Injury, Oxidative Medicine and Cellular Longevity. 2018, 2018: 1-2. |
| Liu J., YAN D., XIE X. and Xia Z., FOXO1 Couples Reactive Oxygen Species in Diabetic Atherosclerosis, FASEB Journal. 2018, 32. |
| Liu Y., Paterson M., Baumgardt S., Irwin M.G., Xia Z., Bosnjak Z. and Ge Z., VEGF regulation of Enos phosphorylation is involved in isoflurane cardiac preconditioning, Cardiovascular. 2018, 21. |
| Wang L., Peng Y., Peng J., Shao M., Ma L., Zhu Z., Zhong G., Xia Z. and Huang H., Tramadol attenuates the sensitivity of glioblastoma to temozolomide through the suppression of Cx43‑mediated gap junction intercellular communication, International Journal of Oncology. 2017. |
| Xia Z., Clinical Application of Remote Ischemic Preconditioning in Perioperative Cardiac Protection: The Challenges and Promises, The 5th South China and international Symposium of Cardiothoracic Vascular Anesthesia. 2018. |
| Xia Z., Guest Editor, Asian Journal of Anesthesiology. 2018. |
| Xia Z., Peer reviewer for journal, Acta Pharmacogica Sinica. 2018. |
| Xia Z., Peer reviewer for journal, Canadian Journal Anesthesia. 2018. |
| Xia Z., Peer reviewer for journal, Diabetes. 2018. |
| Xia Z., Peer reviewer for journal, Journal of Molecular and Cellular Cardiology. 2018. |
| Xia Z., Peer reviewer for journal, Oncotarget. 2017. |
| Xia Z., The remote ischemic preconditioning protection of congenital heart disease with cyanosis, The Chinese Society of Cardiothoracic and Vascular Anesthesiology 2018 annual meeting. 2018. |
| Xia Z., Translational Study of Remote Ischemic Preconditioning and Postconditioning in Cardiac Protection, Chinese Association of Anesthesiologists 2018 annual meeting. 2018. |
| YAN D., Cai Y., Luo J., Liu J., Irwin M.G. and Xia Z., Pharmacologic Inhibition of FOXO1 Improves Cardiac Function by Enhancing Glucose Metabolism and Attenuating Apoptosis in Type-1 Diabetic Rats, FASEB Jpurnal. 2018, 32. |
| YE X.D., HE Y., Wang S., Wong G.T.C., Irwin M.G. and Xia Z., Heart-type fatty acid binding protein (H-FABP) as a biomarker for acute myocardial injury and long-term post-ischemic prognosis, Acta Pharmacologica Sinica. 2018, 39(7): 1155-1163. |
| Yao W., Li H., Han X., Chen C., Zhang Y., Tai W.L., Xia Z. and Hei Z., MG53 anchored by dysferlin to cell membrane reduces hepatocyte apoptosis which induced by ischaemia/reperfusion injury in vivo and in vitro., J Cell Mol Med. 2017, (10): 2503-2513. |
| Yao W., Li H., Luo G., Li X., Chen C., Yuan D., Chi X., Xia Z. and Hei Z., SERPINB1 ameliorates acute lung injury in liver transplantation through ERK1/2-mediated STAT3-dependent HO-1 induction., Free Radic Biol Med. 2017, 108: 542-553. |
| Ying F., Cai Y., Tang E.H.C. and Xia Z., Deficiency of Prostaglandin E2 Receptor Subtype 4 Exacerbates Left Ventricular Remodeling and Myocardial Fibrosis in Diet-induced Mice, FASEB Journal. 2018, 32. |
| Ying F., Cai Y., Wong H.K., CHEN X., Huang B., Vanhoutte P.M.G.R., Xia Z., Xu A. and Tang E.H.C., EP4 emerges as a novel regulator of bile acid synthesis and its activation protects against hypercholesterolemia , BBA - Molecular and Cell Biology of Lipids. 2018. |
| Zhang C., Luo Q., Li Y., Wu X., Hao Z., LI S., Xia Z., Yan F. and Sun L., Predictors of Short-term Outcomes Following Repair of Anomalous Origin of the Left Coronary Artery From the Pulmonary Artery in Chinese Children: A Case-Control Study., J Cardiothorac Vasc Anesth. 2018, 2018 Apr 3. pii: S1053-0770(18)30235-0. |
| Researcher : YAN D |
| List of Research Outputs |
| He Y., Cai Y., YAN D., Zhang D., Chen C., Irwin M.G., Wang S. and Xia Z., MicroRNA-17-3p inhibits excessive post-hypoxic autophagy and attenuates H9C2 cardiomyocytes reoxygenation injury via PTEN-Akt-mTOR signaling, FASEB Journal. 2018, 32. |
| Kosuru R., Cai Y., KANDULA V., YAN D., WANG C., Zheng H., Li Y., Irwin M.G., Singh S. and Xia Z., AMPK Contributes to Cardioprotective Effects of Pterostilbene Against Myocardial Ischemia- Reperfusion Injury in Diabetic Rats by Suppressing Cardiac Oxidative Stress and Apoptosis, Cellular Physiology and Biochemistry. 2018, 46: 1381-1397. |
| Liu J., YAN D., XIE X. and Xia Z., FOXO1 Couples Reactive Oxygen Species in Diabetic Atherosclerosis, FASEB Journal. 2018, 32. |
| YAN D., Cai Y., Luo J., Liu J., Irwin M.G. and Xia Z., Pharmacologic Inhibition of FOXO1 Improves Cardiac Function by Enhancing Glucose Metabolism and Attenuating Apoptosis in Type-1 Diabetic Rats, FASEB Jpurnal. 2018, 32. |
| Researcher : Yao W |
| List of Research Outputs |
| Yao W., Li H., Han X., Chen C., Zhang Y., Tai W.L., Xia Z. and Hei Z., MG53 anchored by dysferlin to cell membrane reduces hepatocyte apoptosis which induced by ischaemia/reperfusion injury in vivo and in vitro., J Cell Mol Med. 2017, (10): 2503-2513. |
| Yao W., Li H., Luo G., Li X., Chen C., Yuan D., Chi X., Xia Z. and Hei Z., SERPINB1 ameliorates acute lung injury in liver transplantation through ERK1/2-mediated STAT3-dependent HO-1 induction., Free Radic Biol Med. 2017, 108: 542-553. |
| Researcher : Ying F |
| List of Research Outputs |
| Ying F., Cai Y., Tang E.H.C. and Xia Z., Deficiency of Prostaglandin E2 Receptor Subtype 4 Exacerbates Left Ventricular Remodeling and Myocardial Fibrosis in Diet-induced Mice, FASEB Journal. 2018, 32. |
| Ying F., Cai Y., Wong H.K., CHEN X., Huang B., Vanhoutte P.M.G.R., Xia Z., Xu A. and Tang E.H.C., EP4 emerges as a novel regulator of bile acid synthesis and its activation protects against hypercholesterolemia , BBA - Molecular and Cell Biology of Lipids. 2018. |
| Researcher : Yuen VMY |
| List of Research Outputs |
| Mu J., Jiang T., Xu X.B., Yuen V.M.Y. and Irwin M.G., Comparison of target-controlled infusion and manual infusion for Propofol anaesthesia in children, British Journal of Anaesthesia. 2018, 120(5): 1049-1055. |
| Mu J.J., Jiang T., Deng L.P., Choi S.W., Irwin M.G. and Yuen V.M.Y., A comparison of two techniques for induction of anaesthesia with target-controlled infusion of propofol, Anaesthesia. 2018, 6 (29). |
| Yuen V.M.Y., LI B.L., Cheuk D.K., Leung K.M.M., Hui T.W.C., Wong I.C., Lam W.W., Choi S.W. and Irwin M.G., A randomised controlled trial of oral chloral hydrate vs. intranasal dexmedetomidine before computerised tomography in children, Anaethesia. 2017, 25. |
| Yuen V.M.Y., Wong C.H.P., Wong S.C.S. and Wong G.T.C., Rescue oxygenation in small infants, Anaesthesia. 2017, 72: 1564-1565. |
| Researcher : Zhang D |
| List of Research Outputs |
| He Y., Cai Y., YAN D., Zhang D., Chen C., Irwin M.G., Wang S. and Xia Z., MicroRNA-17-3p inhibits excessive post-hypoxic autophagy and attenuates H9C2 cardiomyocytes reoxygenation injury via PTEN-Akt-mTOR signaling, FASEB Journal. 2018, 32. |
| Researcher : Zhang Y |
| List of Research Outputs |
| Jin S.Y., Huang J., Zhu H.J., Wu H., XU S.H., Irwin M.G., HE S.F. and Zhang Y., Remifentanil preconditioning confers cardioprotection via c-Jun NH2-terminal kinases and extracellular signal regulated kinases pathways in ex-vivo failing rat heart, European Journal of Pharmacology. 2018, 5(828): 1-8. |
| Researcher : Zhu Q |
| List of Research Outputs |
| Chen X., Wang Y., XIE X., Chen H., Zhu Q., Ge Z., Wei H., Deng J., Xia Z. and Lian Q., Heme Oxygenase-1 Reduces Sepsis-Induced Endoplasmic Reticulum Stress and Acute Lung Injury, Mediators of Inflammation. 2018, 2018: 1-10. |