Dept of Pharmacology & Pharmacy

DEPT OF PHARMACOLOGY & PHARMACY

Researcher : Anand S

List of Research Outputs

Law W.Y., Wong Y.S., Anand S., Wong I.C.K. and Chan E.W., Neuropsychiatric Events Associated with Leukotriene-Modifying Agents: A Systematic Review, Drug Safety. 2017, 41: 253-265.

Researcher : Baretella OM

List of Research Outputs

Baretella O.M., Chung S.K., Xu A. and Vanhoutte P.M.G.R., Paradoxical lack of increase in endothelin-1 levels in obese mice – possible role of endothelin-B receptors, Acta Pharmacologica Sinica. 2017, 38: 1699-1700.

Researcher : CHEN H

List of Research Outputs

CHEN H., Man R.Y.K. and Leung S.W.S., PPAR-α agonists acutely inhibit Ca2+-independent PLA2 to reduce H2O2-induced contractions in aortae of spontaneously hypertensive rats., American Journal of Physiology. Heart and Circulatory Physiology. 2018, 314(3): H681-H691.

CHEN H., Vanhoutte P.M.G.R. and Leung S.W.S., Role of AMPK in EDH-like relaxations in rat superior mesenteric arteries , 21st Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine . 2017.

CHEN H., Role of AMPK in vascular smooth muscle relaxation, 22nd Research Postgraduate Symposium, 6-7 Dec 2017, Hong Kong. 2017.

CHEN H., Vanhoutte P.M.G.R. and Leung S.W.S., The AMPK-activator AICAR reduces EDH-like relaxations in rat superior mesenteric arteries, Pharmacology 2017, 11-13 Dec 2017, The Queen Elizabeth II Conference Centre, London. 2017.

CHEN H., Vanhoutte P.M.G.R. and Leung S.W.S., The AMPK-activator AICAR reduces EDH-like relaxations in rat superior mesenteric arteries, Pharmacology 2017, 11-13 December 2017, London, United Kingdom. 2017.

Researcher : CHEN J

List of Research Outputs

Chen J., Li J., Yiu J.H.C., Lam J.K.W., Wong C.M., Xu A. and Woo W.H.C., TRIF-dependent Toll-like receptor signaling suppresses Scd1 transcription in hepatocytes and prevents diet-induced hepatic steatosis. , Science Signaling. 2017, 10.

Hampe L., Xu C., Harris P.W., CHEN J., LIU M., Middleditch M., Radjainia M., Wang Y. and Mitra A.K., Obesity-related metabolic disorders mitigated by peptides designed to modulate adiponectin assembly, British Journal of Pharmacology. 2017.

Researcher : CHEN X

List of Research Outputs

CHEN X., Deletion of Rap1 aggravates the development of atherosclerosis in apolipoprotein E-deficient mice, 22nd Research Postgraduate Symposium, 6-7 Dec 2017, Hong Kong. 2017.

CHEN X., Xu A. and Tang E.H.C., Deletion of Rap1 promotes macrophage infil-tration and foam cell formation during athero-sclerosis, IVBM2018, 3-7 Jun 2018, Helsinki, Finland. 2018.

Ying F., Cai Y., Wong H.K., CHEN X., Huang B., Vanhoutte P.M.G.R., Xia Z., Xu A. and Tang E.H.C., EP4 emerges as a novel regulator of bile acid synthesis and its activation protects against hypercholesterolemia , BBA - Molecular and Cell Biology of Lipids. 2018.

Researcher : CHENG Y

List of Research Outputs

CHENG Y., Vanhoutte P.M.G.R. and Leung S.W.S., Apolipoprotein E deletion facilitates the relaxation to the prostacyclin receptor agonist iloprost in the mouse aorta- effects of ageing and high fat diet, Pharmacology 2017, 11-13 December 2017, London, United Kingdom. 2017.

CHENG Y., Vanhoutte P.M.G.R. and Leung S.W.S., Apolipoprotein E deletion facilitates the relaxation to the prostacyclin receptor agonist iloprost in the mouse aorta-effects of ageing and high fat diet, Pharmacology 2017, 11-13 Dec 2017, The Queen Elizabeth II Conference Centre, London. 2017.

CHENG Y., Vanhoutte P.M.G.R. and Leung S.W.S., Effects of ages and hyperlipidemia on prostacyclin receptor receptor-mediated relaxations, 21st Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine. 2017.

Researcher : CHEONG LY

List of Research Outputs

CHEONG L.Y., Wang B., Shu L., WU X., Hoo R.L.C. and Xu A., Absence of inguinal lymph nodes impairs the browning of subcutaneous white adipose tissue in mice., 2018 Croucher Symposium - Young Investigator Symposium. 2018.

CHEONG L.Y., Absence of inguinal lymph nodes impairs the browning of white adipose tissue, 22nd Research Postgraduate Symposium, 6-7 Dec 2017, Hong Kong. 2017.

Shu L., Zhong L., WU X., CHEONG L.Y., Zhou Z., Hoo R.L.C. and Xu A., FABP4 mediates autoimmune diabetes by enhancing the crosstalk between innate and adaptive immunity, 13th International Symposium on Healthy Aging “Aging, Health, Happiness”. 2018.

Researcher : CHEUNG J

List of Research Outputs

YIU J.H.C., Li J., FUNG W.L., CHEUNG J., Tso P., Xu A. and Woo W.H.C., Gut microbiota facilitates apolipoprotein A1 and HDL production through hepatic TLR5, ATVB 2018 Scientific Session . 2018.

Researcher : CHOW YT

List of Research Outputs

CHOW Y.T., QIU Y., Lo F.K., Lin H.S., Chan H.K., Kwok P.C.L. and Lam J.K.W., Inhaled powder formulation of naked siRNA using spray drying technology with L-leucine as dispersion enhancer, International Journal of Pharmaceutics. 2017, 531: 40-52.

Chow Y.T., Leung S.S.K. and Lam J.K.W., Preparation and characterization of siRNA-containing microspheres intended for inhalation with mannitol and albumin using spray drying technique, Drug Delivery to the Lungs 2017, Edinburgh, UK. 2017.

Liang W., Chan A.Y.L., CHOW Y.T., Lo F.K., QIU Y., Kwok P.C.L. and Lam J.K.W., Spray freeze drying of small nucleic acids as inhaled powder for pulmonary delivery, Asian Journal of Pharmaceutical Sciences. 2017, 13: 163-172.

QIU Y., Chow Y.T. and Lam J.K.W., Effective gene silencing effect mediated by the KL4/siRNA complexes in lung epithelial cells through clathrin-dependent endocytosis, Drug Delivery to the Lungs 2017, Edinburgh, UK. 2017.

QIU Y., CHOW Y.T., Liang W., Chung W.W.Y., Mak J.C.W. and Lam J.K.W., From Pulmonary Surfactant, Synthetic KL4 Peptide as Effective siRNA Delivery Vector for Pulmonary Delivery, Molecular Pharmaceutics. 2017, 14: 4606-4617.

QIU Y., Chow Y.T. and Lam J.K.W., Pulmonary delivery of siRNA using synthetic peptide KL4 as delivery vector, 4th International Conference: Inhaled Therapies for TB and other Infectious Diseases, North Carolina, USA. 2017.

Researcher : Chan EW

Project Title:	Young adult patient experiences in clinical management of ADHD in Hong Kong
Investigator(s):	Chan EWY
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Janssen Pharmaceutica - General Award
Start Date:	01/2014

Project Title:	Intramuscular olanzapine versus haloperidol or midazolam for the management of acute agitation in the emergency department a multicentre randomised clinical trial.
Investigator(s):	Chan EWY
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	01/2014

Project Title:	Oro-dispersible olanzapine (wafer) versus conventional oral haloperidol or diazepam tablets for the management of acute agitation in the Accident and Emergency Department - a multicentre randomised clinical trial.
Investigator(s):	Chan EWY, Leung LP
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	06/2016

Project Title:	The prescribing trends and safety of biologics in Hong Kong
Investigator(s):	Chan EWY
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

Project Title:	Understanding drug abuser and their healthcare pathways: Towards better management in Hong Kong
Investigator(s):	Chan EWY, Tam AW
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Beat Drugs Fund Association
Start Date:	06/2017

Project Title:	33rd International Conference on Pharmacoepidemiology & Therapeutic Risk Management; Bleeding-related hospital admissions and 30 day readmissions with dabigatran versus warfarin in patients with nonvalavular atrial fibrillation
Investigator(s):	Chan EWY
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2017

Project Title:	Use of targeted therapy in non-small cell lung cancer (NSCLC)
Investigator(s):	Chan EWY, Wong ICK
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Takeda Pharmaceuticals (HK) Ltd
Start Date:	03/2018

List of Research Outputs

Chan E.W., Evidence-based management of acute agitation, Scientific Symposium on Emergency Medicine: Geriatric medical emergencies. Hong Kong Academy of Medicine Jockey Club Building, Aberdeen, Hong Kong. 20 October 2017. 2017.

Chan E.W., Faculty Outstanding Research Output Award, Faculty of Medicine, The University of Hong Kong. 2018.

Cheung K.S., Chan E.W., Wong Y.S., Chen L., Wong I.C.K. and Leung W.K., Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: A population-based study, Gut. 2017, gutjnl-2017-314605.

Cheung K.S.M., Chan E.W., Wong A.Y., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Aspirin and Risk of Gastric Cancer After Helicobacter pylori Eradication: A Territory-Wide Study, JNCI: Journal of the National Cancer Institute. 2018, 110: 743-749.

Cheung K.S.M., Chan E.W., Wong A.Y.S., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Metformin is associated with a reduced gastric cancer risk in patients with diabetes mellitus after Helicobacter Pylori Eradication: A Territory-Wide Study with propensity score adjustment, Digestive Disease Week (DDW). 2018.

Cheung K.S.M., Chen L., Chan E.W., Seto W.K.W., Wong I.C.K. and Leung W.K., Statin use and post-colonoscopy interval cancer in the proximal colon: A population-based study, Digestive Disease Week (DDW). 2018.

Cowling B.J., Chui S.L.C., Lim W.W., Wu P., Hui K.M.C., Peiris J.S.M. and Chan E.W., Use of influenza antivirals in patients hospitalized in Hong Kong, 2000-2015, PLOS ONE. 2018, 13: e0190306.

HUANG D., Wong C.L., Cheng K.W., Chan P.H.M., Yue W.S., Wong C.K., Ho C.W., Wong I.C.K., Chan E.W. and Siu D.C.W., Impact of provision of time in therapeutic range value on anticoagulation management in atrial fibrillation patients on warfarin, Postgraduate Medical Journal. 2018, 94: 207-211.

HUANG D., Cheng Y., Chan P.H.M., Hai S.H.J.J., Yiu K.H., Tse H.F., Wong K.L., Fan K., Li Y.W., Ng W.L., Yim C.W., Wong C.J., Tam L.S., Wong P.C.H., Wong C.Y., Ho C.H., Leung A.M.H., Mok C.C., Lam H., Lau C.S., Cheung T.T., Ho C.T.K., Law W.Y., Chan E.W., Yin L.X., Yue W.S., Mok T.M., Evora M.A. and Siu D.C.W., Rationale and design of the screening of pulmonary hypertension in systemic lupus erythematosus (SOPHIE) study, ERJ Open Research. 2018, 4: 00135-2017.

HUANG D., Chan P.H.M., She H.L., Wong C.K., Ho C.W., Cheng Y.Y., Chan E.W., Chiang C.E. and Siu D.C.W., Secular trends and etiologies of venous thromboembolism in Chinese from 2004 to 2016, Thrombosis Research. 2018, 166: 80-85.

LAO S., Chan E.W. and Wong I.C.K., Prescribing trend of antipsychotic in Hong Kong: From 2004 to 2014, ACPE 2017, ISPE's 10th Asian Conference on Pharmacoepidemiology, 29-31 Oct 2017, Brisbane, Australia. 2017.

LAU C.Y., Li X., Wong I.C.K., Man K.C.K., Lip G.Y.H., Leung W.K., Siu D.C.W. and Chan E.W., Bleeding-Related Hospital Admissions and 30-Day Re-Admissions in Patients with Nonvalvular Atrial Fibrillation Treated with Dabigatran versus Warfarin, Journal of Thrombosis and Haemostasis. 2017, 15: 1923-1933.

LAU C.Y., Wong I.C.K. and Chan E.W., Osteoporotic Fractures Associated With Dabigatran vs Warfarin—Reply, JAMA. 2017, 318: 91.

Law W.Y., Wong Y.S., Anand S., Wong I.C.K. and Chan E.W., Neuropsychiatric Events Associated with Leukotriene-Modifying Agents: A Systematic Review, Drug Safety. 2017, 41: 253-265.

Leung W.K., Wong O.L., Cheung K.S.M., Yeung K.F., Chan E.W., Wong Y.S., Chen L., Wong I.C.K. and Graham D.Y., Effects of Helicobacter pylori treatment on incidence of gastric cancer in older individuals, Gastroenterology. 2018, 155: 67-75.

Leung W.K., Chan E.W., WONG Y.S., Chen L., Wong I.C.K. and Cheung K.S., Long-term proton pump inhibitors and risk of gastric cancer development after treatment for H. pylori: a population-based study, Gut. 2017, 67: 28-35.

Leung W.K., Wong O.L., Chan E.W., Wong A., Yeung K.F., Chen L., Wong I. and Cheung K.S.M., Top Abstract Award, 25th United European Gastroenterology Week, Barcelona, Spain , United European Gastroenterology. 2017.

Man K.C.K., Coghill D., Chan E.W., LAU C.Y., Hollis C., Liddle E., Banaschewski T., McCarthy S., Neubert A., Sayal K., Ip P., Schuemie M.J., Sturkenboom M.C.J.M., Sonuga-Barke E., Buitelaar J., Carucci S., Zuddas A., Kovshoff H., Garas P., Nagy P., Inglis S.K., Konrad K., Häge A., Rosenthal E. and Wong I.C.K., Association of Risk of Suicide Attempts With Methylphenidate Treatment, JAMA Psychiatry. 2017, 74: 1048–1055.

Man K.C.K., Ip P., Chan E.W., Law S.L., Leung M.T.Y., Ma E.X.Y., Quek W.T. and Wong I.C.K., Effectiveness of Pharmacological Treatment for Attention-Deficit/Hyperactivity Disorder on Physical Injuries: A Systematic Review and Meta-Analysis of Observational Studies, CNS Drugs. 2017, 31: 1043-1055.

Man K.C.K., Chan E.W., Ip P., Coghill D., Simonoff E., Chan P.K.L., Lau W.C.Y., Schuemie M.J., Sturkenboom M.C.J.M. and Wong I.C.K., Prenatal antidepressant exposure and the risk of attention-deficit hyperactivity disorder in children: A systematic review and meta-analysis, Neuroscience & Biobehavioral Reviews. 2018, 86: 1-11.

Wong Y.S., Wong I.C.K., Chui S.L.C., Lee H.M.E., Chang W.C., Chen E.Y.H., Leung W.K. and Chan E.W., Faculty Outstanding Research Output Award, Faculty Outstanding Research Output Award. 2017.

Yap C.Y.L., Hsueh Y.S., Knott J.C., Taylor D.M., Chan E.W. and Kong D.C.M., Economic evaluation of midazolam–droperidol combination, versus droperidol or olanzapine for the management of acute agitation in the emergency department: A within-trial analysis, PharmacoEconomics - Open. 2017, 2: 141-151.

Researcher : Chan WLP

List of Research Outputs

Chan L.K., Ganotice F.J.A., Wong F.K.Y., Lau W.C.S., Bridges S.M., Chan C.H.Y., Chan N.K., Chan W.L.P., Chen H., Chen J.Y., Chu K.P.J., Ho C.C., Ho J.M.C., Lam T.P., Lam S.F., Li Q., Shen J., Tanner J.A., Tso W.Y.W., Wong A.K.C., Wong G.T.C., Wong J.Y.H., Wong N.S., Worsley A.J., Yu L.K. and Yum T.P., Implementation of an interprofessional team-based learning program involving seven undergraduate health and social care programs from two universities, and students’ evaluation of their readiness for interprofessional learning, BMC Medical Education. 2017, 17.

Chan W.L.P., 香港臨床藥學的教育與實踐, 海峡兩岸暨港澳健康服務與管理人才高峰論壇, 2017.

To H.H.M., Chang R.S.K., Chan A.O.K. and Chan W.L.P., Effect of plasmapheresis on serum levels of clobazam, levetiracetam and topiramate, Epilepsy & Behavior Case Reports. Elsevier, 2017, 8: 66-68.

Yuen C.W.S. and Chan W.L.P., Students’ Performance in Pharmacy Objective Structured Clinical Examination (OSCE) and Written Examinations – A Comparative Study, 9th Asian Medical Education Association Symposium. 2017.

Researcher : Chan WYE

Project Title:	Young adult patient experiences in clinical management of ADHD in Hong Kong
Investigator(s):	Chan EWY
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Janssen Pharmaceutica - General Award
Start Date:	01/2014

Project Title:	Intramuscular olanzapine versus haloperidol or midazolam for the management of acute agitation in the emergency department a multicentre randomised clinical trial.
Investigator(s):	Chan EWY
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	01/2014

Project Title:	Oro-dispersible olanzapine (wafer) versus conventional oral haloperidol or diazepam tablets for the management of acute agitation in the Accident and Emergency Department - a multicentre randomised clinical trial.
Investigator(s):	Chan EWY, Leung LP
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	06/2016

Project Title:	The prescribing trends and safety of biologics in Hong Kong
Investigator(s):	Chan EWY
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

Project Title:	Understanding drug abuser and their healthcare pathways: Towards better management in Hong Kong
Investigator(s):	Chan EWY, Tam AW
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Beat Drugs Fund Association
Start Date:	06/2017

Project Title:	33rd International Conference on Pharmacoepidemiology & Therapeutic Risk Management; Bleeding-related hospital admissions and 30 day readmissions with dabigatran versus warfarin in patients with nonvalavular atrial fibrillation
Investigator(s):	Chan EWY
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2017

Project Title:	Use of targeted therapy in non-small cell lung cancer (NSCLC)
Investigator(s):	Chan EWY, Wong ICK
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Takeda Pharmaceuticals (HK) Ltd
Start Date:	03/2018

List of Research Outputs

Researcher : Cheung CL

Project Title:	Genetics and genomics of anti-thyroid drug induced agranulocytosis
Investigator(s):	Cheung CL, Kung AWC, Tan KCB, Sham PC, Wong ICK
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015
Completion Date:	12/2017

Project Title:	The role of Vitamin D and bone metabolism in cardiovascular events risk, an interaction or mediation? An 11 year follow-up study
Investigator(s):	Cheung CL, Tan KCB, Kung AWC, Cheung BMY
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	02/2015

Project Title:	Pharmacogenomics Assessment of Serious Cutaneous Adverse drug reactions (PASCA): A retrospective study
Investigator(s):	Cheung CL, Chan CYJ, Sham PC, Cheung BMY, Wong ICK
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	Metabolomic Study of Osteoporosis in Southern Chinese
Investigator(s):	Cheung CL
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	09/2016

Project Title:	Identification of susceptibility genes involved in the pathogenesis and prediction of thyrotoxic periodic paralysis
Investigator(s):	Cheung CL
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2017

Project Title:	*Genetic screening service of HLA-B38:02 in people prescribing antithyroid drug**
Investigator(s):	Cheung CL, Tan KCB, Cheung BMY
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	03/2017

Project Title:	GREM2: A novel blood-based biomarker for osteoporosis and metabolic syndrome?
Investigator(s):	Cheung CL
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Fund for Basic Research for Resubmission of GRF/ECS Proposals
Start Date:	07/2017
Completion Date:	11/2017

Project Title:	American Society of Bone and Mineral Research ASBMR 2017 Annual Meeting; Glycemic traits are related to phosphate metabolism: A double-edged sword
Investigator(s):	Cheung CL
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2017
Completion Date:	09/2017

Project Title:	AKAP11 as a positive regulator of osteogenesis
Investigator(s):	Cheung CL, Lu WW, Tan KCB
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2018

Project Title:	A comprehensive program for evaluation of musculoskeletal health and pharmacist medication review
Investigator(s):	Cheung CL, Chu KPJ
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Beat Drugs Fund Association
Start Date:	05/2018

List of Research Outputs

Cheung C.L., Ang S.B., Chadha M., Chow E.S., Chung Y.S., Hew F.L., Jaisamrarn U., Ng H., Takeuchi Y., Wu C.H., Xia W., Yu J. and Fujiwara S., An updated hip fracture projection in Asia: The Asian Federation of Osteoporosis Societies study, Osteoporos Sarcopenia. 2018, 4(1): 16-21.

Cheung C.L., Tan K.C.B. and Kung A.W.C., Cohort Profile: The Hong Kong Osteoporosis Study and the follow-up study, International Journal of Epidemiology. 2018, 47: 397-398f.

Ip P.C.P., YU Y., Cheung C.L., Cheuk W., Cheung E., Wong W.C., Lee V., Chan W.K. and Tse K.Y., Female Genital melanomas: A clinicopathologic and PD-L1 expression study, The United States and Canadian Academy of Pathology 107th Annual Meeting . 2018.

Moayyeri A., Cheung C.L., Tan K.C.B., Morris J.A., Cerani A., Mohney R.P., Richards J.B., Hammond C., Spector T. and Menni C., Metabolomic Pathways to Osteoporosis in Middle-Aged Women: A Genome-Metabolome-Wide Mendelian Randomization Study, Journal of Bone and Mineral Research. 2018, 33: 643-650.

SING C.W., Woo Y.C., Lee A.C., Lam J.K., Chu K.P.J., Wong I.C.K. and Cheung C.L., Validity Of Major Osteoporotic Fracture Diagnosis Codes In The Clinical Data Analysis And Reporting System In Hong Kong, Pharmacoepidemiology and Drug Safety. 2017, 26(8): 973-976.

Tan K., Cheung C.L., Yeung C.Y., Siu D., Leung J. and Pang H.K., Genetic screening for familial hypercholesterolaemia in Hong Kong, Hong Kong Med J. 2018, 24 Suppl 3(3): 7-10.

Tan K.C.B., Cheung C.L., Lee C.H.A., Lam K.Y.J., Wong Y. and Shiu S.W.M., Galectin-3 is independently associated with progression of nephropathy in type 2 diabetes mellitus, Diabetologia. 2018, 61: 1212-1219.

Wong H.Y., LEE K.Y. and Cheung C.L., Metabolomics of Sarcopenia in Hong Kong Chinese, Annual Meeting of American Society for Bone and Mineral Research 2017.

Wong H.Y., LEE K.Y. and Cheung C.L., Travel Award for Eleventh EFF/ASBMR Fellows Forum on Metabolic Bone Diseases, Denver, Colorado, USA. 2017, Endocrine Fellows Foundation. 2017.

Researcher : Cho CH

Project Title:	Advances in GI Pharmacology - From Acid Secretion to Mucosal Protection Symposium Non-ulcerogenic Dose of Dexamethasone Delays Gastric Ulcer Healing in Rats
Investigator(s):	Cho CH
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2004

Project Title:	Adrenaline and its receptor activation on colon cancer growth
Investigator(s):	Cho CH
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	02/2006

Researcher : Chow SF

List of Research Outputs

Chow S.F., Scientific Advisor to the Editors, Journal of Pharmaceutical Sciences. 2018.

Lai K.L., Fang Y., Han H., Li Q., Zhang S., Li H.Y., Chow S.F., Lam T.N. and Lee T.W.Y., Orally-dissolving film for sublingual and buccal delivery of ropinirole, Colloids and Surfaces B: Biointerfaces. 2018, 163: 9-18.

Wan K.Y., Wong K.W., Chow A.H.L. and Chow S.F., Impact of molecular rearrangement of amphiphilic stabilizers on physical stability of itraconazole nanoparticles prepared by flash nanoprecipitation, International Journal of Pharmaceutics. 2018, 542: 221-231.

Researcher : Chow YT

List of Research Outputs

Researcher : Chu KPJ

List of Research Outputs

Chan L.K., Ganotice F.J.A., Wong F.K.Y., Lau W.C.S., Bridges S.M., Chan C.H.Y., Chan N.K., Chan W.L.P., Chen H., Chen J.Y., Chu K.P.J., Ho C.C., Ho J.M.C., Lam T.P., Lam S.F., Li Q., Shen J., Tanner J.A., Tso W.Y.W., Wong A.K.C., Wong G.T.C., Wong J.Y.H., Wong N.S., Worsley A.J., Yu L.K. and Yum T.P., Implementation of an interprofessional team-based learning program involving seven undergraduate health and social care programs from two universities, and students’ evaluation of their readiness for interprofessional learning, BMC Medical Education. 2017, 17.

SING C.W., Woo Y.C., Lee A.C., Lam J.K., Chu K.P.J., Wong I.C.K. and Cheung C.L., Validity Of Major Osteoporotic Fracture Diagnosis Codes In The Clinical Data Analysis And Reporting System In Hong Kong, Pharmacoepidemiology and Drug Safety. 2017, 26(8): 973-976.

Researcher : Chui SLC

Project Title:	ASM Microbes 2018; Inpatient Antibiotic Prescribing Trends among Public Hospitals in Hong Kong
Investigator(s):	Chui SLC
Department:	School of Public Health
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2018
Completion Date:	06/2018

List of Research Outputs

Wong Y.S., Wong I.C.K., Chui S.L.C., Lee H.M.E., Chang W.C., Chen E.Y.H., Leung W.K. and Chan E.W., Faculty Outstanding Research Output Award, Faculty Outstanding Research Output Award. 2017.

Researcher : DETREMMERIE CMS

List of Research Outputs

Leung S.W.S., DETREMMERIE C.M.S. and Vanhoutte P.M.G.R., Endothelium-dependent contractions depending on biased sGC activation: the Janus face of thymoquinone, International Conference on the Mechanism of Action of Nutraceuticals and the International Union of Basic and Clinical Pharmacology; Natural Products Section, 27-29 September 2017, Aberdeen, Scotland, United Kingdom . 2017.

Researcher : Dufay S

Project Title:	Quantitation of Dexmedetomidine in plasma for pharmacokinetic study after intranasal administration in healthy volunteers
Investigator(s):	Dufay S, Irwin MG, Wong ICK
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2013

Researcher : FENG T

List of Research Outputs

FENG T. and Hui X., Adipose Tissue, Adipose Tissue as an Endocrine Organ. 2018.

FENG T., The role of lactate in macrophage polarization and adipose tissue inflammation, 22nd Research Postgraduate Symposium, 6-7 Dec 2017, Hong Kong. 2017.

Researcher : FUNG WL

List of Research Outputs

YIU J.H.C., Li J., FUNG W.L., CHEUNG J., Tso P., Xu A. and Woo W.H.C., Gut microbiota facilitates apolipoprotein A1 and HDL production through hepatic TLR5, ATVB 2018 Scientific Session . 2018.

Researcher : Guo Y

List of Research Outputs

Guo Y. and Wang Y., Targeting endothelial SIRT1 for the prevention of arterial aging, Endothelial Dysfunction. InTech press, 2018, 978-953-51-5698-7.

LUO D., Guo Y., CHENG Y., Zhao J., Wang Y. and Rong J., Natural product celastrol suppressed macrophage M1 polarization against inflammation in diet-induced obese mice via regulating Nrf2/HO-1, MAP kinase and NF-κB pathways, Aging. 2017.

Researcher : HE C

List of Research Outputs

HE C., Effects of ouabain on endothelium-dependent response, 22nd Research Postgraduate Symposium, 6-7 Dec 2017, Hong Kong. 2017.

HE C., Vanhoutte P.M.G.R. and Leung S.W.S., Effects of sodium and ouabain on endothelium-dependent responses in hypertension, 21st Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine. 2017.

Researcher : Hoo RLC

Project Title:	The inter-relationship between A-FABF, endoplasmic reticulum stress and autophagy in the pathogenesis of obesity-induced imflammation
Investigator(s):	Hoo RLC, Zhang J
Department:	Medicine
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2013

Project Title:	Adipocyte fatty acid binding protein (A-FABP) as a potential mediator of cardiac dysfunction and heart failure related to diabetes and obesity
Investigator(s):	Hoo RLC, Xia Z, Xu A
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014
Completion Date:	01/2018

Project Title:	Adipocyte fatty acid binding protein (A-FABP) is a potential therapeutic target of both alcoholic and non-alcoholic steatohepatitis
Investigator(s):	Hoo RLC, Xu A
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	The role of adipocyte fatty acid binding protein (A-FABP) in the pathogenesis of ischemic stroke associating with obesity
Investigator(s):	Hoo RLC, Xu A
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016
Completion Date:	03/2018

Project Title:	Adipocyte fatty acid binding protein (A-FABP) is a pathological mediator of obesity-related renal dysfunction.
Investigator(s):	Hoo RLC, Xu A
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2016
Completion Date:	02/2019

Project Title:	The role of lipid chaperone ap2 in regional adipose tissue expandability
Investigator(s):	Hoo RLC, Xu A
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017

Project Title:	53rd EASD Meeting 2017 ; Adipocyte fatty acid binding protein (A-FABP) is a pathological mediator of obesity related renal dysfunction
Investigator(s):	Hoo RLC
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2017
Completion Date:	09/2017

Project Title:	The roles of neutrophil elastase (NE) and proteinase 3 (PR3) in the conversion of white to brown adipocytes
Investigator(s):	Hoo RLC, Xu A
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2018

List of Research Outputs

CHEONG L.Y., Wang B., Shu L., WU X., Hoo R.L.C. and Xu A., Absence of inguinal lymph nodes impairs the browning of subcutaneous white adipose tissue in mice., 2018 Croucher Symposium - Young Investigator Symposium. 2018.

LIAO B., Chung S.K., Lam K.S.L., Xu A. and Hoo R.L.C., Adipocyte fatty acid binding protein mediates ischemic stroke, Mini-symposium on brain and adipose tissue crosstalk 2017. 2017.

Shu L., Zhong L., WU X., CHEONG L.Y., Zhou Z., Hoo R.L.C. and Xu A., FABP4 mediates autoimmune diabetes by enhancing the crosstalk between innate and adaptive immunity, 13th International Symposium on Healthy Aging “Aging, Health, Happiness”. 2018.

Shu L., Zhong L., Xiao Y., Hoo R.L.C. and Xu A., Pharmacological Inhibition of Neutrophil Elastase Attenuates Insulitis &Autoimmune Diabetes in Mice , American Diabetes Association 78th Scientific sessions . 2018.

WU X., Shu L., Lam K.S.L., Xu A. and Hoo R.L.C., The Role of Adipocyte Fatty Acid Binding Protein in the Development of Liver Fibrosis, American Diabetes Association 78th Scientific Sessions, 22-26 Jun 2018, Orlando, FL. 2018.

ZHOU Y., CHENG K.K.Y., Xu A. and Hoo R.L.C., Metabolic Profiling of Serum Reveals Significant Changes in Lipid and Amino Acid Metabolism in a Lipodystrophy Mouse Model, EXPERIMENTAL BIOLOGY 2018, 21-25 Apr 2018, San Diego, California. 2018.

Researcher : Kwan CM

List of Research Outputs

Chui C.H., Tang Y.M.J., Kwan C.M., Chan O.F., Tse M.A., Chiu R.L.H., Lou V.W., Chau P.H., Leung A.Y.M. and Lum T.Y.S., Older Adults’ Perceptions of Age-friendliness in Hong Kong, The Gerontologist. 2018.

Gani L., Lau E., Luk A., Sobrepena L., Khanh T.Q., Kesavadev J., Jia W., Yu W., Tsang C.C., Monojitketan M., Jha S., Sheu W., Yoon K.H., Nguyen T.K., Ozaki R., So W.Y., Kwan C.M., Fu A.W.C., Mirasol R., Phatak S.R., Kumar K.M.P., Aravind S.R., Janakiraman H. and Chan J.C.N., A Cross-Sectional Survey of Biosimilar Insulin Utilisation in Asia - The Joint Asia Diabetes Evaluation (JADE) Programme, Journal of Diabetes Investigation. 2018.

Researcher : Kwok PCL

Project Title:	Aerosol performance of generic pharmaceutical combination inhalers
Investigator(s):	Kwok PCL
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Small Project Funding
Start Date:	04/2015
Completion Date:	07/2017

Project Title:	Dexmedetomidine buccal spray solution for premedication in children
Investigator(s):	Kwok PCL, Dufay S, Yuen VMY
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Health and Medical Research Fund - Mini Grant
Start Date:	05/2015

Project Title:	Transport of dexmedetomidine across the nasal mucosa
Investigator(s):	Kwok PCL
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016
Completion Date:	07/2017

List of Research Outputs

CHOW Y.T., QIU Y., Lo F.K., Lin H.S., Chan H.K., Kwok P.C.L. and Lam J.K.W., Inhaled powder formulation of naked siRNA using spray drying technology with L-leucine as dispersion enhancer, International Journal of Pharmaceutics. 2017, 531: 40-52.

Liang W., Chan A.Y.L., CHOW Y.T., Lo F.K., QIU Y., Kwok P.C.L. and Lam J.K.W., Spray freeze drying of small nucleic acids as inhaled powder for pulmonary delivery, Asian Journal of Pharmaceutical Sciences. 2017, 13: 163-172.

Researcher : LAO S

List of Research Outputs

LAO S., Chan E.W. and Wong I.C.K., Prescribing trend of antipsychotic in Hong Kong: From 2004 to 2014, ACPE 2017, ISPE's 10th Asian Conference on Pharmacoepidemiology, 29-31 Oct 2017, Brisbane, Australia. 2017.

Researcher : LAU CY

List of Research Outputs

LAU C.Y., Li X., Wong I.C.K., Man K.C.K., Lip G.Y.H., Leung W.K., Siu D.C.W. and Chan E.W., Bleeding-Related Hospital Admissions and 30-Day Re-Admissions in Patients with Nonvalvular Atrial Fibrillation Treated with Dabigatran versus Warfarin, Journal of Thrombosis and Haemostasis. 2017, 15: 1923-1933.

LAU C.Y., Wong I.C.K. and Chan E.W., Osteoporotic Fractures Associated With Dabigatran vs Warfarin—Reply, JAMA. 2017, 318: 91.

Man K.C.K., Coghill D., Chan E.W., LAU C.Y., Hollis C., Liddle E., Banaschewski T., McCarthy S., Neubert A., Sayal K., Ip P., Schuemie M.J., Sturkenboom M.C.J.M., Sonuga-Barke E., Buitelaar J., Carucci S., Zuddas A., Kovshoff H., Garas P., Nagy P., Inglis S.K., Konrad K., Häge A., Rosenthal E. and Wong I.C.K., Association of Risk of Suicide Attempts With Methylphenidate Treatment, JAMA Psychiatry. 2017, 74: 1048–1055.

Researcher : LEE KY

List of Research Outputs

Wong H.Y., LEE K.Y. and Cheung C.L., Metabolomics of Sarcopenia in Hong Kong Chinese, Annual Meeting of American Society for Bone and Mineral Research 2017.

Wong H.Y., LEE K.Y. and Cheung C.L., Travel Award for Eleventh EFF/ASBMR Fellows Forum on Metabolic Bone Diseases, Denver, Colorado, USA. 2017, Endocrine Fellows Foundation. 2017.

Researcher : LI J

List of Research Outputs

Chen J., Li J., Yiu J.H.C., Lam J.K.W., Wong C.M., Xu A. and Woo W.H.C., TRIF-dependent Toll-like receptor signaling suppresses Scd1 transcription in hepatocytes and prevents diet-induced hepatic steatosis. , Science Signaling. 2017, 10.

LI J., Zhang J., Zou L., Lee S.M.Y., Yang C., Seto S.W. and Leung G.P.H., Pro-angiogenic effects of Ilexsaponin A1 on human umbilical vein endothelial cells in vitro and zebrafish in vivo, Phytomedicine. 2017, 36: 229-237.

LI J., ZHANG J. and Leung G.P.H., Synergistic effects of doxorubicin and ordonin on suppressing cancer growth via pro-apoptotic and anti-angiogenic pathways, Pharmacology 2017, 11-13 Dec 2017, The Queen Elizabeth II Conference Centre, London. 2017.

Researcher : LI Y

List of Research Outputs

Li J., LI Y., Wang Y., Ke W., Chen W., Wang W. and Ge Z., Polymer Prodrug-Based Nanoreactors Activated by Tumor Acidity for Orchestrated Oxidation/Chemotherapy, Nano Letters. 2017, 17: 6983-6990.

Researcher : Lam JKW

Project Title:	Development of a highly effective, pH responsive peptide, siRNA delivery system to the respiratory tract to combat influenza virus infections
Investigator(s):	Lam JKW, Poon LML
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015
Completion Date:	12/2017

Project Title:	Porous nanoparticle aerosol carriers with controllable density for pulmonary drug delivery
Investigator(s):	Lam JKW, Kwok PCL
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	Development of a highly efficient inhalable mucosal DNA vaccine against HIV as dry powder using pH responsive LAH peptides with nuclear localizing sequence as DNA carrier
Investigator(s):	Lam JKW, Chen Z, Kwok PCL, Lan Y, Chu YJ
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2016

Project Title:	Role of pulmonary surfactants on siRNA delivery to the airway
Investigator(s):	Lam JKW
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016
Completion Date:	03/2018

Project Title:	Inhalable dry powder formulation of naked siRNA using spray-drying and spray freeze-drying technologies for the treatment of respiratory infections
Investigator(s):	Lam JKW, Kwok PCL
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2016

Project Title:	Aerosolized formulation of antifungal drugs for pulmonary fungal infections
Investigator(s):	Lam JKW
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

Project Title:	Lung surfactant inspired peptide-based vector for pulmonary delivery of small nucleic acid therapeutics
Investigator(s):	Lam JKW
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2018

List of Research Outputs

CHOW Y.T., QIU Y., Lo F.K., Lin H.S., Chan H.K., Kwok P.C.L. and Lam J.K.W., Inhaled powder formulation of naked siRNA using spray drying technology with L-leucine as dispersion enhancer, International Journal of Pharmaceutics. 2017, 531: 40-52.

Chen J., Li J., Yiu J.H.C., Lam J.K.W., Wong C.M., Xu A. and Woo W.H.C., TRIF-dependent Toll-like receptor signaling suppresses Scd1 transcription in hepatocytes and prevents diet-induced hepatic steatosis. , Science Signaling. 2017, 10.

Chow Y.T., Leung S.S.K. and Lam J.K.W., Preparation and characterization of siRNA-containing microspheres intended for inhalation with mannitol and albumin using spray drying technique, Drug Delivery to the Lungs 2017, Edinburgh, UK. 2017.

Lam J.K.W., Dry powder formulation of RNAi therapeutics for inhalation, 4th Inhaled Therapies for TB and other Infectious Diseases, Durham, North Carolina, USA. 16th October 2017 . 2017.

Lam J.K.W., Inhaled nucleic acid therapeutics and vaccines, Better, Safer, and Cheaper Medicine: A 21st Century Mandate, School of Pharmacy, Chinese University of Hong Kong. 4th November, 2017. 2017.

Liang W., Lo F.K. and Lam J.K.W., Formulation of inhaled antifungal agent as dry powder using spray freeze drying technology, Inhalation Asia 2017, Macau. 2017.

Liang W., Chan A.Y.L., CHOW Y.T., Lo F.K., QIU Y., Kwok P.C.L. and Lam J.K.W., Spray freeze drying of small nucleic acids as inhaled powder for pulmonary delivery, Asian Journal of Pharmaceutical Sciences. 2017, 13: 163-172.

Liang W., Chan A.Y.L. and Lam J.K.W., The investigation of using spray freeze drying small nucleic acids dry powders formulation for pulmonary delivery, 4th International Conference: Inhaled Therapies for TB and other Infectious Diseases, North Carolina, USA. 2017.

Liang W. and Lam J.K.W., The use of spray freeze drying technology to produce nucleic acid formulation for pulmonary delivery, Inhalation Asia 2017, Macau. 2017.

Perinelli D.R., Fagioli L., Campana R., Lam J.K.W., Baffone W., Palmieri G.F., Casettari L. and Giulia B., Chitosan-based nanosystems and their exploited antimicrobial activity, European Journal of Pharmaceutical Sciences. 2018, 117: 8-20.

Perinelli D.R., Cespi M., Pucciarelli S., Vincenzetti S., Casettari L., Lam J.K.W., Logrippo S., Canala E., Soliman M.E., Bonaucina G. and Palmieri G.F., Water-in-Oil Microemulsions for Protein Delivery: Loading Optimization and Stability, Current Pharmaceutical Biotechnology. 2017, 18: 410-421.

QIU Y., Chow Y.T. and Lam J.K.W., Effective gene silencing effect mediated by the KL4/siRNA complexes in lung epithelial cells through clathrin-dependent endocytosis, Drug Delivery to the Lungs 2017, Edinburgh, UK. 2017.

QIU Y., CHOW Y.T., Liang W., Chung W.W.Y., Mak J.C.W. and Lam J.K.W., From Pulmonary Surfactant, Synthetic KL4 Peptide as Effective siRNA Delivery Vector for Pulmonary Delivery, Molecular Pharmaceutics. 2017, 14: 4606-4617.

QIU Y., Chow Y.T. and Lam J.K.W., Pulmonary delivery of siRNA using synthetic peptide KL4 as delivery vector, 4th International Conference: Inhaled Therapies for TB and other Infectious Diseases, North Carolina, USA. 2017.

Raik S., Andranovitš S., Petrova V., XU Y., Lam J.K.W., Morris G., Brodskaia A., Casettari L., Kritchenkov A. and Skorik Y., Comparative Study of Diethylaminoethyl-Chitosan and Methylglycol-Chitosan as Potential Non-Viral Vectors for Gene Therapy, Polymers. 2018, 10: 442.

Researcher : Law WY

List of Research Outputs

HUANG D., Cheng Y., Chan P.H.M., Hai S.H.J.J., Yiu K.H., Tse H.F., Wong K.L., Fan K., Li Y.W., Ng W.L., Yim C.W., Wong C.J., Tam L.S., Wong P.C.H., Wong C.Y., Ho C.H., Leung A.M.H., Mok C.C., Lam H., Lau C.S., Cheung T.T., Ho C.T.K., Law W.Y., Chan E.W., Yin L.X., Yue W.S., Mok T.M., Evora M.A. and Siu D.C.W., Rationale and design of the screening of pulmonary hypertension in systemic lupus erythematosus (SOPHIE) study, ERJ Open Research. 2018, 4: 00135-2017.

Law W.Y., Wong Y.S., Anand S., Wong I.C.K. and Chan E.W., Neuropsychiatric Events Associated with Leukotriene-Modifying Agents: A Systematic Review, Drug Safety. 2017, 41: 253-265.

Researcher : Leung GPH

Project Title:	Cloning and characterization of novel equilibrative nucleoside transporter type 4 (ENT4)
Investigator(s):	Leung GPH
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2005

Project Title:	Protective effects of Pleurotus ostreatus (Oyster mushroom) and ergothioneine against doxorubicin-induced cardiotoxicity
Investigator(s):	Leung GPH, Xia Z, Zhang Y, So TH
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2016

Project Title:	Role of equilibrative nucleoside transporter-2 in the development of neonatal heart cells
Investigator(s):	Leung GPH
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2016
Completion Date:	04/2018

Project Title:	Development of novel equilibrative nucleoside transporter-2 inhibitor and its application in studying the functions of equilibrative nucleoside transporter-2 in skeletal muscle
Investigator(s):	Leung GPH, Ballard HJ
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2016

Project Title:	Role of equilibrative nucleoside transporter-4 in ischemic brain damage
Investigator(s):	Leung GPH
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

Project Title:	Role of equilibrative nucleoside transporter-4 in the cardioprotection against ischemia-reperfusion injury in diabetes mellitus
Investigator(s):	Leung GPH, Xia Z
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2018

Project Title:	Effects of Danshensu on increasing the therapeutic to adverse effect ratio of bevacizumab
Investigator(s):	Leung GPH
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2018

List of Research Outputs

CHEN X., LAM K.H., CHEN Q., Leung G.P.H., Tang S.C.W., Sze C.W.S., Xiao J., Feng F., Wang Y., Zhang Y. and Zhang Z., Ficus virens proanthocyanidins induced apoptosis in breast cancer cells concomitantly ameliorated 5-fluorouracil induced intestinal mucositis in rats, Food and Chemical Toxicology. 2017, 110: 49-61.

CHEN X., Leung G.P.H., Zhang Z., Xiao J.B., Lao L., Feng F., Mak J.C.W., Wang Y., Sze C.W.S. and Zhang Y., Proanthocyanidins from Uncaria rhynchophylla induced apoptosis in MDA-MB-231 breast cancer cells while enhancing cytotoxic effects of 5-fluorouracil, Food and Chemical Toxicology. 2017, 107: 248-260.

LI J., Zhang J., Zou L., Lee S.M.Y., Yang C., Seto S.W. and Leung G.P.H., Pro-angiogenic effects of Ilexsaponin A1 on human umbilical vein endothelial cells in vitro and zebrafish in vivo, Phytomedicine. 2017, 36: 229-237.

LI J., ZHANG J. and Leung G.P.H., Synergistic effects of doxorubicin and ordonin on suppressing cancer growth via pro-apoptotic and anti-angiogenic pathways, Pharmacology 2017, 11-13 Dec 2017, The Queen Elizabeth II Conference Centre, London. 2017.

Leung G.P.H., Pharmacological properties of edible mushrooms: their implications in cardiovascular protection, The 10th Pong Ding Yuen International Symposium on Traditional Chinese Medicine - Drug Discovery from Chinese Medicines: Strategies for Complicated Diseases, 2-3 December 2017.. 2017.

Li S., Ai N., Shen M., Dang Y., Chong C.M., Pan P., Kwan Y.W., Chan S.W., Leung G.P.H., Hoi M.P.M., Hou T. and Lee S.M., Discovery of a ROCK inhibitor, FPND, which prevents cerebral hemorrhage through maintaining vascular integrity by interference with VE-cadherin, Cell Death Discovery. 2017, 3: 17051.

Researcher : Leung SWS

Project Title:	Therapeutic potential of herbal flavonoids in the management of chronic obstructive pulmonary disease
Investigator(s):	Leung SWS, Mak JCW, Man RYK
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	11/2013
Completion Date:	07/2017

Project Title:	Vasoconstrictor signals in hypoxia: role of soluble guanylyl cyclase
Investigator(s):	Leung SWS, Vanhoutte PMGR
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015
Completion Date:	12/2017

Project Title:	Vascular effect of thymoquinone, a natural product used in humans as a folk medicine
Investigator(s):	Leung SWS, Vanhoutte PMGR
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016
Completion Date:	05/2018

Project Title:	MicroRNA-17-3p curtails endothelial dysfunction and vascular inflammation
Investigator(s):	Leung SWS, Vanhoutte PMGR
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

Project Title:	Effects of microRNA-17-3p upregulation on vascular inflammation and endothelial dysfunction caused by the human immunodeficiency virus proteins
Investigator(s):	Leung SWS, Lam JKW, Vanhoutte PMGR
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2017

Project Title:	International Conference on the Mechanism of Action of Nutraceuticals (ICMAN) and the International Union of Basic and Clinical Pharmacology (IUPHAR); Natural Products Section; Endothelium-dependent contractions depending on biased sGC activation: the Janus face of thymoquinone
Investigator(s):	Leung SWS
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2017
Completion Date:	09/2017

Project Title:	Effects of activation of adenosine monophosphate-activated protein kinase (AMPK) on endothelium-dependent hyperpolarization-like relaxations in mesenteric arteries of normotensive and hypertensive rats
Investigator(s):	Leung SWS, Vanhoutte PMGR
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2018

Project Title:	Paradoxical vasoconstrictor effect of thymoquinone, a natural product known to induce vasodilatation and used in humans
Investigator(s):	Leung SWS, Vanhoutte PMGR
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2018

List of Research Outputs

CHEN H., Man R.Y.K. and Leung S.W.S., PPAR-α agonists acutely inhibit Ca2+-independent PLA2 to reduce H2O2-induced contractions in aortae of spontaneously hypertensive rats., American Journal of Physiology. Heart and Circulatory Physiology. 2018, 314(3): H681-H691.

CHEN H., Vanhoutte P.M.G.R. and Leung S.W.S., Role of AMPK in EDH-like relaxations in rat superior mesenteric arteries , 21st Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine . 2017.

CHEN H., Vanhoutte P.M.G.R. and Leung S.W.S., The AMPK-activator AICAR reduces EDH-like relaxations in rat superior mesenteric arteries, Pharmacology 2017, 11-13 Dec 2017, The Queen Elizabeth II Conference Centre, London. 2017.

CHEN H., Vanhoutte P.M.G.R. and Leung S.W.S., The AMPK-activator AICAR reduces EDH-like relaxations in rat superior mesenteric arteries, Pharmacology 2017, 11-13 December 2017, London, United Kingdom. 2017.

CHENG Y., Vanhoutte P.M.G.R. and Leung S.W.S., Apolipoprotein E deletion facilitates the relaxation to the prostacyclin receptor agonist iloprost in the mouse aorta- effects of ageing and high fat diet, Pharmacology 2017, 11-13 December 2017, London, United Kingdom. 2017.

CHENG Y., Vanhoutte P.M.G.R. and Leung S.W.S., Apolipoprotein E deletion facilitates the relaxation to the prostacyclin receptor agonist iloprost in the mouse aorta-effects of ageing and high fat diet, Pharmacology 2017, 11-13 Dec 2017, The Queen Elizabeth II Conference Centre, London. 2017.

CHENG Y., Vanhoutte P.M.G.R. and Leung S.W.S., Effects of ages and hyperlipidemia on prostacyclin receptor receptor-mediated relaxations, 21st Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine. 2017.

HE C., Vanhoutte P.M.G.R. and Leung S.W.S., Effects of sodium and ouabain on endothelium-dependent responses in hypertension, 21st Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine. 2017.

Leung S.W.S., DETREMMERIE C.M.S. and Vanhoutte P.M.G.R., Endothelium-dependent contractions depending on biased sGC activation: the Janus face of thymoquinone, International Conference on the Mechanism of Action of Nutraceuticals and the International Union of Basic and Clinical Pharmacology; Natural Products Section, 27-29 September 2017, Aberdeen, Scotland, United Kingdom . 2017.

Wong E.S.W., Man R.Y.K., Ng K.F.J., Leung S.W.S. and Vanhoutte P.M.G.R., L-arginine and Arginase Products Potentiate Dexmedetomidine-induced Contractions in the Rat Aorta, Anesthesiology. 2018, 128: 564-573.

Researcher : Li X

List of Research Outputs

LAU C.Y., Li X., Wong I.C.K., Man K.C.K., Lip G.Y.H., Leung W.K., Siu D.C.W. and Chan E.W., Bleeding-Related Hospital Admissions and 30-Day Re-Admissions in Patients with Nonvalvular Atrial Fibrillation Treated with Dabigatran versus Warfarin, Journal of Thrombosis and Haemostasis. 2017, 15: 1923-1933.

Researcher : Liang W

List of Research Outputs

Liang W., Lo F.K. and Lam J.K.W., Formulation of inhaled antifungal agent as dry powder using spray freeze drying technology, Inhalation Asia 2017, Macau. 2017.

Liang W., Chan A.Y.L., CHOW Y.T., Lo F.K., QIU Y., Kwok P.C.L. and Lam J.K.W., Spray freeze drying of small nucleic acids as inhaled powder for pulmonary delivery, Asian Journal of Pharmaceutical Sciences. 2017, 13: 163-172.

Liang W., Chan A.Y.L. and Lam J.K.W., The investigation of using spray freeze drying small nucleic acids dry powders formulation for pulmonary delivery, 4th International Conference: Inhaled Therapies for TB and other Infectious Diseases, North Carolina, USA. 2017.

Liang W. and Lam J.K.W., The use of spray freeze drying technology to produce nucleic acid formulation for pulmonary delivery, Inhalation Asia 2017, Macau. 2017.

QIU Y., CHOW Y.T., Liang W., Chung W.W.Y., Mak J.C.W. and Lam J.K.W., From Pulmonary Surfactant, Synthetic KL4 Peptide as Effective siRNA Delivery Vector for Pulmonary Delivery, Molecular Pharmaceutics. 2017, 14: 4606-4617.

Researcher : Lo FK

List of Research Outputs

CHOW Y.T., QIU Y., Lo F.K., Lin H.S., Chan H.K., Kwok P.C.L. and Lam J.K.W., Inhaled powder formulation of naked siRNA using spray drying technology with L-leucine as dispersion enhancer, International Journal of Pharmaceutics. 2017, 531: 40-52.

Liang W., Lo F.K. and Lam J.K.W., Formulation of inhaled antifungal agent as dry powder using spray freeze drying technology, Inhalation Asia 2017, Macau. 2017.

Liang W., Chan A.Y.L., CHOW Y.T., Lo F.K., QIU Y., Kwok P.C.L. and Lam J.K.W., Spray freeze drying of small nucleic acids as inhaled powder for pulmonary delivery, Asian Journal of Pharmaceutical Sciences. 2017, 13: 163-172.

Researcher : Lui WYV

Project Title:	A Precision Therapeutic Tool for Head and Neck Cancer (HNC)
Investigator(s):	Lui WYV
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	03/2015

Project Title:	HKU Overseas Fellowship Awards 2015-16
Investigator(s):	Lui WYV
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	HKU Overseas Fellowship Awards
Start Date:	06/2015

Researcher : Man RYK

List of Research Outputs

CHEN H., Man R.Y.K. and Leung S.W.S., PPAR-α agonists acutely inhibit Ca2+-independent PLA2 to reduce H2O2-induced contractions in aortae of spontaneously hypertensive rats., American Journal of Physiology. Heart and Circulatory Physiology. 2018, 314(3): H681-H691.

Wong E.S.W., Man R.Y.K., Ng K.F.J., Leung S.W.S. and Vanhoutte P.M.G.R., L-arginine and Arginase Products Potentiate Dexmedetomidine-induced Contractions in the Rat Aorta, Anesthesiology. 2018, 128: 564-573.

Researcher : Man WCA

List of Research Outputs

Man W.C.A. and Wang Y., Age-Associated Arterial Remodelling. , EC Cardiology . 2018, 4: 137-164.

Researcher : QIU Y

List of Research Outputs

CHOW Y.T., QIU Y., Lo F.K., Lin H.S., Chan H.K., Kwok P.C.L. and Lam J.K.W., Inhaled powder formulation of naked siRNA using spray drying technology with L-leucine as dispersion enhancer, International Journal of Pharmaceutics. 2017, 531: 40-52.

Liang W., Chan A.Y.L., CHOW Y.T., Lo F.K., QIU Y., Kwok P.C.L. and Lam J.K.W., Spray freeze drying of small nucleic acids as inhaled powder for pulmonary delivery, Asian Journal of Pharmaceutical Sciences. 2017, 13: 163-172.

QIU Y., Chow Y.T. and Lam J.K.W., Effective gene silencing effect mediated by the KL4/siRNA complexes in lung epithelial cells through clathrin-dependent endocytosis, Drug Delivery to the Lungs 2017, Edinburgh, UK. 2017.

QIU Y., CHOW Y.T., Liang W., Chung W.W.Y., Mak J.C.W. and Lam J.K.W., From Pulmonary Surfactant, Synthetic KL4 Peptide as Effective siRNA Delivery Vector for Pulmonary Delivery, Molecular Pharmaceutics. 2017, 14: 4606-4617.

QIU Y., Chow Y.T. and Lam J.K.W., Pulmonary delivery of siRNA using synthetic peptide KL4 as delivery vector, 4th International Conference: Inhaled Therapies for TB and other Infectious Diseases, North Carolina, USA. 2017.

Researcher : SING CW

List of Research Outputs

SING C.W., Woo Y.C., Lee A.C., Lam J.K., Chu K.P.J., Wong I.C.K. and Cheung C.L., Validity Of Major Osteoporotic Fracture Diagnosis Codes In The Clinical Data Analysis And Reporting System In Hong Kong, Pharmacoepidemiology and Drug Safety. 2017, 26(8): 973-976.

Researcher : Tam YTE

List of Research Outputs

Tam Y.T.E., How To Improve Medication Adherence , International Conference Of Chinese Rheumatologists (iccr). 2017.

Researcher : Tang EHC

Project Title:	Telomere-independent Rap1 contributes to inflammation during atherosclerosis
Investigator(s):	Tang EHC, Man RYK, Leung SWS
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2013

Project Title:	Regulation of triglyceride metabolism by prostaglandin E receptor subtype 4
Investigator(s):	Tang EHC
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2013

Project Title:	Rap1 aggravates the development of angiotensin II-induced aortic abdominal aneurysm in apolipoprotein E-deficient mice.
Investigator(s):	Tang EHC
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014

Project Title:	Enhancement of the fat-burning capacity of white and brown adipose tissue by activation of prostaglandin E receptor subtype 4
Investigator(s):	Tang EHC
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	12/2014
Completion Date:	12/2017

Project Title:	Unexpected role of the telomere-associated protein Rap1 in protecting against endothelial dysfunction
Investigator(s):	Tang EHC, Vanhoutte PMGR, Xu A
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017
Completion Date:	12/2017

List of Research Outputs

CHEN X., Xu A. and Tang E.H.C., Deletion of Rap1 promotes macrophage infil-tration and foam cell formation during athero-sclerosis, IVBM2018, 3-7 Jun 2018, Helsinki, Finland. 2018.

Ying F., Cai Y., Tang E.H.C. and Xia Z., Deficiency of Prostaglandin E2 Receptor Subtype 4 Exacerbates Left Ventricular Remodeling and Myocardial Fibrosis in Diet-induced Mice, FASEB Journal. 2018, 32.

Ying F., Cai Y., Wong H.K., CHEN X., Huang B., Vanhoutte P.M.G.R., Xia Z., Xu A. and Tang E.H.C., EP4 emerges as a novel regulator of bile acid synthesis and its activation protects against hypercholesterolemia , BBA - Molecular and Cell Biology of Lipids. 2018.

Researcher : Tang HC

Project Title:	Telomere-independent Rap1 contributes to inflammation during atherosclerosis
Investigator(s):	Tang EHC, Man RYK, Leung SWS
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2013

Project Title:	Regulation of triglyceride metabolism by prostaglandin E receptor subtype 4
Investigator(s):	Tang EHC
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2013

Project Title:	Rap1 aggravates the development of angiotensin II-induced aortic abdominal aneurysm in apolipoprotein E-deficient mice.
Investigator(s):	Tang EHC
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2014

Project Title:	Enhancement of the fat-burning capacity of white and brown adipose tissue by activation of prostaglandin E receptor subtype 4
Investigator(s):	Tang EHC
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	12/2014
Completion Date:	12/2017

Project Title:	Unexpected role of the telomere-associated protein Rap1 in protecting against endothelial dysfunction
Investigator(s):	Tang EHC, Vanhoutte PMGR, Xu A
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017
Completion Date:	12/2017

List of Research Outputs

Researcher : Tom WM

Project Title:	VII World Conference on Clinical Pharmacology and Therapeutics 4th Congress of the European Association for Clinical Pharmacology and Therapeutics Antidotal Mechanisms of Hydroxyacetone and Dihydroxyacetone in the Treatment of Acute Acetonitrile Poisoning
Investigator(s):	Tom WM
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2000

Researcher : Vanhoutte P.M.G.

Project Title:	Annual Summer School in Danish Cardiovascular Research Academy Veins in health and disease
Investigator(s):	Vanhoutte PMGR
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2007

Project Title:	Visiting Research Professors Scheme 2009-10
Investigator(s):	Vanhoutte PMGR
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Visiting Research Professors Scheme
Start Date:	09/2009

Project Title:	A Study of the Relative Significance of Nitric Oxide Synthase vs NADPH oxidase in Endothelial Senescence
Investigator(s):	Vanhoutte PMGR, Wang Y
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Small Project Funding
Start Date:	10/2009

Project Title:	Human Prostacyclin Receptors and Endothelial Dysfunction
Investigator(s):	Vanhoutte PMGR, Xu A, Wang Y, Leung SWS
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2016

List of Research Outputs

Researcher : Vanhoutte PMGR

Project Title:	Annual Summer School in Danish Cardiovascular Research Academy Veins in health and disease
Investigator(s):	Vanhoutte PMGR
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2007

Project Title:	Visiting Research Professors Scheme 2009-10
Investigator(s):	Vanhoutte PMGR
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Visiting Research Professors Scheme
Start Date:	09/2009

Project Title:	A Study of the Relative Significance of Nitric Oxide Synthase vs NADPH oxidase in Endothelial Senescence
Investigator(s):	Vanhoutte PMGR, Wang Y
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Small Project Funding
Start Date:	10/2009

Project Title:	Human Prostacyclin Receptors and Endothelial Dysfunction
Investigator(s):	Vanhoutte PMGR, Xu A, Wang Y, Leung SWS
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2016

List of Research Outputs

Baretella O.M., Chung S.K., Xu A. and Vanhoutte P.M.G.R., Paradoxical lack of increase in endothelin-1 levels in obese mice – possible role of endothelin-B receptors, Acta Pharmacologica Sinica. 2017, 38: 1699-1700.

CHEN H., Vanhoutte P.M.G.R. and Leung S.W.S., Role of AMPK in EDH-like relaxations in rat superior mesenteric arteries , 21st Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine . 2017.

CHEN H., Vanhoutte P.M.G.R. and Leung S.W.S., The AMPK-activator AICAR reduces EDH-like relaxations in rat superior mesenteric arteries, Pharmacology 2017, 11-13 Dec 2017, The Queen Elizabeth II Conference Centre, London. 2017.

CHEN H., Vanhoutte P.M.G.R. and Leung S.W.S., The AMPK-activator AICAR reduces EDH-like relaxations in rat superior mesenteric arteries, Pharmacology 2017, 11-13 December 2017, London, United Kingdom. 2017.

CHENG Y., Vanhoutte P.M.G.R. and Leung S.W.S., Apolipoprotein E deletion facilitates the relaxation to the prostacyclin receptor agonist iloprost in the mouse aorta- effects of ageing and high fat diet, Pharmacology 2017, 11-13 December 2017, London, United Kingdom. 2017.

CHENG Y., Vanhoutte P.M.G.R. and Leung S.W.S., Apolipoprotein E deletion facilitates the relaxation to the prostacyclin receptor agonist iloprost in the mouse aorta-effects of ageing and high fat diet, Pharmacology 2017, 11-13 Dec 2017, The Queen Elizabeth II Conference Centre, London. 2017.

CHENG Y., Vanhoutte P.M.G.R. and Leung S.W.S., Effects of ages and hyperlipidemia on prostacyclin receptor receptor-mediated relaxations, 21st Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine. 2017.

Choy K.W., Lau Y.S., Murugan D., Vanhoutte P.M.G.R. and Mustafa M.R., Paeonol Attenuates LPS-Induced Endothelial Dysfunction and Apoptosis by Inhibiting BMP4 and TLR4 Signaling Simultaneously but Independently, Journal of Pharmacology and Experimental Therapeutics. 2018, 364: 420-432.

Doytcheva P., Bachler T., Tarasco E., Marzolla V., Engeli M., Pellegrini G., Stivala S., Rohrer L., Tona F., Camici G.G., Vanhoutte P.M.G.R., Matter C.M., Lutz T.A., Luscher T.F. and Osto E., Inhibition of Vascular c‐Jun N‐Terminal Kinase 2 Improves Obesity‐Induced Endothelial Dysfunction After Roux‐en‐Y Gastric Bypass, Journal of the American Heart Association. 2017, 6.

HE C., Vanhoutte P.M.G.R. and Leung S.W.S., Effects of sodium and ouabain on endothelium-dependent responses in hypertension, 21st Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine. 2017.

Leung S.W.S., DETREMMERIE C.M.S. and Vanhoutte P.M.G.R., Endothelium-dependent contractions depending on biased sGC activation: the Janus face of thymoquinone, International Conference on the Mechanism of Action of Nutraceuticals and the International Union of Basic and Clinical Pharmacology; Natural Products Section, 27-29 September 2017, Aberdeen, Scotland, United Kingdom . 2017.

Thuesen A.D., Andersen K., Lyngso K.S., Burton M., Brasch-Andersen C., Vanhoutte P.M.G.R. and Hansen P.B.L., Deletion of T-type calcium channels Cav3.1 or Cav3.2 attenuates endothelial dysfunction in aging mice, Pflügers Archiv - European Journal of Physiology. 2018, 470: 355-365.

Tong K.L., Mahmood Zuhdi A., Wan Ahmad W., Vanhoutte P.M.G.R., de Magalhaes J., Mustafa M. and Wong P.F., Circulating MicroRNAs in Young Patients with Acute Coronary Syndrome, International Journal of Molecular Sciences. 2018, 19: 1467.

Wong E.S.W., Man R.Y.K., Ng K.F.J., Leung S.W.S. and Vanhoutte P.M.G.R., L-arginine and Arginase Products Potentiate Dexmedetomidine-induced Contractions in the Rat Aorta, Anesthesiology. 2018, 128: 564-573.

Ying F., Cai Y., Wong H.K., CHEN X., Huang B., Vanhoutte P.M.G.R., Xia Z., Xu A. and Tang E.H.C., EP4 emerges as a novel regulator of bile acid synthesis and its activation protects against hypercholesterolemia , BBA - Molecular and Cell Biology of Lipids. 2018.

Researcher : WONG YS

List of Research Outputs

Cheung K.S., Chan E.W., Wong Y.S., Chen L., Wong I.C.K. and Leung W.K., Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: A population-based study, Gut. 2017, gutjnl-2017-314605.

Law W.Y., Wong Y.S., Anand S., Wong I.C.K. and Chan E.W., Neuropsychiatric Events Associated with Leukotriene-Modifying Agents: A Systematic Review, Drug Safety. 2017, 41: 253-265.

Leung W.K., Wong O.L., Cheung K.S.M., Yeung K.F., Chan E.W., Wong Y.S., Chen L., Wong I.C.K. and Graham D.Y., Effects of Helicobacter pylori treatment on incidence of gastric cancer in older individuals, Gastroenterology. 2018, 155: 67-75.

Leung W.K., Chan E.W., WONG Y.S., Chen L., Wong I.C.K. and Cheung K.S., Long-term proton pump inhibitors and risk of gastric cancer development after treatment for H. pylori: a population-based study, Gut. 2017, 67: 28-35.

Wong Y.S., Wong I.C.K., Chui S.L.C., Lee H.M.E., Chang W.C., Chen E.Y.H., Leung W.K. and Chan E.W., Faculty Outstanding Research Output Award, Faculty Outstanding Research Output Award. 2017.

Researcher : WU X

List of Research Outputs

CHEONG L.Y., Wang B., Shu L., WU X., Hoo R.L.C. and Xu A., Absence of inguinal lymph nodes impairs the browning of subcutaneous white adipose tissue in mice., 2018 Croucher Symposium - Young Investigator Symposium. 2018.

Shu L., Zhong L., WU X., CHEONG L.Y., Zhou Z., Hoo R.L.C. and Xu A., FABP4 mediates autoimmune diabetes by enhancing the crosstalk between innate and adaptive immunity, 13th International Symposium on Healthy Aging “Aging, Health, Happiness”. 2018.

WU X., Shu L., Lam K.S.L., Xu A. and Hoo R.L.C., The Role of Adipocyte Fatty Acid Binding Protein in the Development of Liver Fibrosis, American Diabetes Association 78th Scientific Sessions, 22-26 Jun 2018, Orlando, FL. 2018.

Researcher : Wang Y

Project Title:	Outstanding Young Researcher Award 2009-10
Investigator(s):	Wang Y
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	12/2010

Project Title:	Molecular dissection of the pathogenic adipose-vascular signaling axis associated with obesity - focusing on polyamination and deamidation of lipocalin-2
Investigator(s):	Wang Y, Yuen KY
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Role of Endothelial SIRT1 in the Prevention of Vascular Ageing - focusing on arterial remodeling and circadian rhythmicity
Investigator(s):	Wang Y, Vanhoutte PMGR
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	09/2016

Project Title:	Timely resetting mitochondrial function by SIRT1 in adipose tissue determines the pace of metabolic ageing in mice
Investigator(s):	Wang Y
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

Project Title:	Selective overexpression of SIRT1 in adipose tissue protects adiponectin deficiency induced liver injury
Investigator(s):	Wang Y, Xu C
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2017

Project Title:	Role of lipocalin-2 in adipose tissue expansion, phenotypic switching and fibrotic damages during the development of cardiometabolic syndrome
Investigator(s):	Wang Y, Sun WY
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

Project Title:	Lipocalin-2: a key mediator of tissue fibrosis in obesity-associated cardiometabolic renal syndrome
Investigator(s):	Wang Y, Vanhoutte PMGR
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2018

Project Title:	Experimental Biology 2018; Endothelial SIRT1 prevents age-induced impairment of vasodilator responses by enhancing the expression and activity of soluble guanylyl cyclase
Investigator(s):	Wang Y
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2018
Completion Date:	04/2018

List of Research Outputs

Guo Y. and Wang Y., Targeting endothelial SIRT1 for the prevention of arterial aging, Endothelial Dysfunction. InTech press, 2018, 978-953-51-5698-7.

Hampe L., Xu C., Harris P.W., CHEN J., LIU M., Middleditch M., Radjainia M., Wang Y. and Mitra A.K., Obesity-related metabolic disorders mitigated by peptides designed to modulate adiponectin assembly, British Journal of Pharmacology. 2017.

Huang Z., Zhong L., LEE T.H.J., Zhang J., GENG L., Wang Y., Wong C.M. and Xu A., The FGF21-CCL11 Axis Mediates Beiging of White Adipose Tissues by Coupling Sympathetic Nervous System to Type 2 Immunity., In: Domenico Accili, David Altshuler, Nancy Andrews, et al., Cell Metabolism. 2017, S1550-4131: 30488-6.

LUO D., Guo Y., CHENG Y., Zhao J., Wang Y. and Rong J., Natural product celastrol suppressed macrophage M1 polarization against inflammation in diet-induced obese mice via regulating Nrf2/HO-1, MAP kinase and NF-κB pathways, Aging. 2017.

Man W.C.A. and Wang Y., Age-Associated Arterial Remodelling. , EC Cardiology . 2018, 4: 137-164.

Mohamad M., Loy S.L., Lim P.Y., Soo K.L., Wang Y. and Mohamed H.J.J., Maternal serum and breast milk adiponectin: association with infant adiposity development., International Journal of Environmental Research and Public Health . 2018, 15: pii: E1250. doi: 10.3390/ijerph15061250.

Wang Y., Anti-vascular ageing effects of endothelial SIRT1, Center for Translational Vascular Biology, Johannes Gutenberg University Medical Center, Mainz, Germany. 2017.

Wang Y., Endothelial SIRT1 and arterial ageing. , 12th International Symposium on Resistance Arteries, Manchester, UK. 2017.

Wang Y., Endothelial SIRT1 as a drug target for vascular ageing-related diseases. , Jagiellonian Centre for Experimental Therapeutics - the 99th invited speaker. 2017.

Wang Y., Endothelial SIRT1 as a novel target for the prevention of early vascular ageing. , 2017 Singapore Symposium on Metabolic Diseases, Singapore.. 2017.

Wang Y., Lipocalin-2 in obesity-related cardiometabolic syndrome: from risk prediction to therapeutic intervention., The 12th Asia Pacific Diabetes & Obesity Study Group Symposium, Hong Kong. . 2017.

Researcher : Wang Y.

Project Title:	Outstanding Young Researcher Award 2009-10
Investigator(s):	Wang Y
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	12/2010

Project Title:	Molecular dissection of the pathogenic adipose-vascular signaling axis associated with obesity - focusing on polyamination and deamidation of lipocalin-2
Investigator(s):	Wang Y, Yuen KY
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Role of Endothelial SIRT1 in the Prevention of Vascular Ageing - focusing on arterial remodeling and circadian rhythmicity
Investigator(s):	Wang Y, Vanhoutte PMGR
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	09/2016

Project Title:	Timely resetting mitochondrial function by SIRT1 in adipose tissue determines the pace of metabolic ageing in mice
Investigator(s):	Wang Y
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

Project Title:	Selective overexpression of SIRT1 in adipose tissue protects adiponectin deficiency induced liver injury
Investigator(s):	Wang Y, Xu C
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2017

Project Title:	Role of lipocalin-2 in adipose tissue expansion, phenotypic switching and fibrotic damages during the development of cardiometabolic syndrome
Investigator(s):	Wang Y, Sun WY
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

Project Title:	Lipocalin-2: a key mediator of tissue fibrosis in obesity-associated cardiometabolic renal syndrome
Investigator(s):	Wang Y, Vanhoutte PMGR
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2018

Project Title:	Experimental Biology 2018; Endothelial SIRT1 prevents age-induced impairment of vasodilator responses by enhancing the expression and activity of soluble guanylyl cyclase
Investigator(s):	Wang Y
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2018
Completion Date:	04/2018

List of Research Outputs

Researcher : Wong HK

List of Research Outputs

Ying F., Cai Y., Wong H.K., CHEN X., Huang B., Vanhoutte P.M.G.R., Xia Z., Xu A. and Tang E.H.C., EP4 emerges as a novel regulator of bile acid synthesis and its activation protects against hypercholesterolemia , BBA - Molecular and Cell Biology of Lipids. 2018.

Researcher : Wong HY

Project Title:	ASBMR 2017 Annual Meeting; Metabolomics of sarcopenia in Hong Kong Chinese
Investigator(s):	Wong HY
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2017
Completion Date:	09/2017

List of Research Outputs

Wong H.Y., LEE K.Y. and Cheung C.L., Metabolomics of Sarcopenia in Hong Kong Chinese, Annual Meeting of American Society for Bone and Mineral Research 2017.

Wong H.Y., LEE K.Y. and Cheung C.L., Travel Award for Eleventh EFF/ASBMR Fellows Forum on Metabolic Bone Diseases, Denver, Colorado, USA. 2017, Endocrine Fellows Foundation. 2017.

Researcher : Wong ICK

Project Title:	Feasibility study of the effects of clonidine and melatonin treatment on sleep architecture of children with ADHD.
Investigator(s):	Wong ICK
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	04/2015

List of Research Outputs

Botzenhardt S., Felisi M., Bonifazi D., Del Vechio G.C., Putti M.C., Kattamis A., Ceci A., Wong I.C.K. and Neubert A., Long-term safety of deferiprone treatment in children from the Mediterranean region with beta-thalassemia major: the DEEP-3 multi-center observational safety study, Haematologica. 2018, 103: e1-e4.

Cheung K.S., Chan E.W., Wong Y.S., Chen L., Wong I.C.K. and Leung W.K., Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: A population-based study, Gut. 2017, gutjnl-2017-314605.

Cheung K.S.M., Chan E.W., Wong A.Y., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Aspirin and Risk of Gastric Cancer After Helicobacter pylori Eradication: A Territory-Wide Study, JNCI: Journal of the National Cancer Institute. 2018, 110: 743-749.

Cheung K.S.M., Chan E.W., Wong A.Y.S., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Metformin is associated with a reduced gastric cancer risk in patients with diabetes mellitus after Helicobacter Pylori Eradication: A Territory-Wide Study with propensity score adjustment, Digestive Disease Week (DDW). 2018.

Cheung K.S.M., Chen L., Chan E.W., Seto W.K.W., Wong I.C.K. and Leung W.K., Statin use and post-colonoscopy interval cancer in the proximal colon: A population-based study, Digestive Disease Week (DDW). 2018.

Christie D., Hudson L.D., Kinra S., Wong I.C.K., Nazareth I., Cole T.J., Sovio U., Gregson J., Kessel A.S., Mathiot A., Morris S., Panca M., Costa S., Holt R. and Viner R.M., A community-based motivational personalised lifestyle intervention to reduce BMI in obese adolescents: results from the Healthy Eating and Lifestyle Programme (HELP) randomised controlled trial, Archives of Disease in Childhood. 2017, 102: 695-701.

HUANG D., Wong C.L., Cheng K.W., Chan P.H.M., Yue W.S., Wong C.K., Ho C.W., Wong I.C.K., Chan E.W. and Siu D.C.W., Impact of provision of time in therapeutic range value on anticoagulation management in atrial fibrillation patients on warfarin, Postgraduate Medical Journal. 2018, 94: 207-211.

Hudson L., Kinra S., Wong I.C.K., Cole T.J., Deanfield J. and Viner R., Is arterial stiffening associated with adiposity, severity of obesity and other contemporary cardiometabolic markers in a community sample of adolescents with obesity in the UK?, BMJ Paediatrics Open. 2017, 1: e000061.

LAO S., Chan E.W. and Wong I.C.K., Prescribing trend of antipsychotic in Hong Kong: From 2004 to 2014, ACPE 2017, ISPE's 10th Asian Conference on Pharmacoepidemiology, 29-31 Oct 2017, Brisbane, Australia. 2017.

LAU C.Y., Wong I.C.K. and Chan E.W., Osteoporotic Fractures Associated With Dabigatran vs Warfarin—Reply, JAMA. 2017, 318: 91.

Law W.Y., Wong Y.S., Anand S., Wong I.C.K. and Chan E.W., Neuropsychiatric Events Associated with Leukotriene-Modifying Agents: A Systematic Review, Drug Safety. 2017, 41: 253-265.

Leung W.K., Wong O.L., Cheung K.S.M., Yeung K.F., Chan E.W., Wong Y.S., Chen L., Wong I.C.K. and Graham D.Y., Effects of Helicobacter pylori treatment on incidence of gastric cancer in older individuals, Gastroenterology. 2018, 155: 67-75.

Leung W.K., Chan E.W., WONG Y.S., Chen L., Wong I.C.K. and Cheung K.S., Long-term proton pump inhibitors and risk of gastric cancer development after treatment for H. pylori: a population-based study, Gut. 2017, 67: 28-35.

Man K.C.K., Ip P., Chan E.W., Law S.L., Leung M.T.Y., Ma E.X.Y., Quek W.T. and Wong I.C.K., Effectiveness of Pharmacological Treatment for Attention-Deficit/Hyperactivity Disorder on Physical Injuries: A Systematic Review and Meta-Analysis of Observational Studies, CNS Drugs. 2017, 31: 1043-1055.

Murphy D., Glaser K., Hayward H., Eklund H., Cadman T., Findon J., Woodhourse E., Ashwood K., Beecham J., Bolton P., McEwen F., Wilson E., Ecker C., Wong I.C.K., Simonoff E., Russell A., McCarthy J., Chaplin E., Young S. and Asherson P., Crossing the divide: a longitudinal study of effective treatments for people with autism and attention deficit hyperactivity disorder across the lifespan, Programme Grants for Applied Research. 2018, 6: 1-240.

Naser A.Y., Wang Q., Wong L.Y.L., Ilomaki J., Bell J.S., Fang G., Wong I.C.K. and Wei L., Author Correction: Hospital Admissions due to Dysglycaemia and Prescriptions of Antidiabetic Medications in England and Wales: An Ecological Study, Diabetes Therapy. 2018, 9: 439-439.

Naser A.Y., Wang Q., Wong L.Y.L., Ilomaki J., Bell J.S., Fang G., Wong I.C.K. and Wei L., Hospital Admissions due to Dysglycaemia and Prescriptions of Antidiabetic Medications in England and Wales: An Ecological Study, Diabetes Therapy. 2018, 9: 153-163.

Panca M., Christie D., Cole T.J., Costa S., Gregson J., Holt R., Hudson L.D., Kessel A.S., Kinra S., Mathiot A., Nazareth I., Wataranan J., Wong I.C.K., Viner R.M. and Morris S., Cost-effectiveness of a community-delivered multicomponent intervention compared with enhanced standard care of obese adolescents: cost-utility analysis alongside a randomised controlled trial (the HELP trial)., BMJ. 2018, 8(2): e018640.

Rann O., Sharland M., Long P., Wong I.C.K., Laverty A.A., Bottle A., Barker C.I., Bielicki J. and Saxena S., Did the accuracy of oral amoxicillin dosing of children improve after British National Formulary dose revisions in 2014? National cross-sectional survey in England, BMJ Open. 2017, 7: e016363.

SING C.W., Woo Y.C., Lee A.C., Lam J.K., Chu K.P.J., Wong I.C.K. and Cheung C.L., Validity Of Major Osteoporotic Fracture Diagnosis Codes In The Clinical Data Analysis And Reporting System In Hong Kong, Pharmacoepidemiology and Drug Safety. 2017, 26(8): 973-976.

Viner R.M., Kinra S., Nicholls D., Cole T., Kessel A., Christie D., White B., Croker H., Wong I.C.K. and Saxena S., Burden of child and adolescent obesity on health services in England, Archives of Disease in Childhood. 2017, archdischild-2017-313009.

White B., Doyle J., Matschull K., Adamo M., Christie D., Nicholls D., Kinra S., Wong I.C.K. and Viner R.M., Outcomes of 50 patients entering an adolescent bariatric surgery programme, Archives of Disease in Childhood. 2017, 102: 1152-1156.

White B., Hsia Y., Kinra S., Saxena S., Christie D., Viner R.M. and Wong I.C.K., Survey of antiobesity drug prescribing for obese children and young people in UK primary care, BMJ Paediatrics Open. 2017, 1: e000104.

Wong Y.S., Wong I.C.K., Chui S.L.C., Lee H.M.E., Chang W.C., Chen E.Y.H., Leung W.K. and Chan E.W., Faculty Outstanding Research Output Award, Faculty Outstanding Research Output Award. 2017.

Researcher : Wong YS

List of Research Outputs

Law W.Y., Wong Y.S., Anand S., Wong I.C.K. and Chan E.W., Neuropsychiatric Events Associated with Leukotriene-Modifying Agents: A Systematic Review, Drug Safety. 2017, 41: 253-265.

Wong Y.S., Wong I.C.K., Chui S.L.C., Lee H.M.E., Chang W.C., Chen E.Y.H., Leung W.K. and Chan E.W., Faculty Outstanding Research Output Award, Faculty Outstanding Research Output Award. 2017.

Researcher : Woo WHC

Project Title:	Maternal Lipid Trafficking mediated by Gut Microbiota and TLR5
Investigator(s):	Woo WHC
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016
Completion Date:	05/2018

Project Title:	Anticipation of Gut Microbiota in Atheroprotection via TLR5 signaling
Investigator(s):	Woo WHC
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

Project Title:	Gut-derived flagellin ameliorates diet-induced dyslipidemia by upregulating apolipoprotein-A1
Investigator(s):	Woo WHC, Xu A
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2018

Project Title:	ATVB\|PVD Scientific Sessions; Gut Microbiota Facilitates Apolipoprotein A1 And HDL Production Through Hepatic TLR5
Investigator(s):	Woo WHC
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2018
Completion Date:	05/2018

Project Title:	TLR5 is an obligatory signaling molecule for UCP1 expression in adaptive thermogenesis
Investigator(s):	Woo WHC
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2018

List of Research Outputs

Chen J., Li J., Yiu J.H.C., Lam J.K.W., Wong C.M., Xu A. and Woo W.H.C., TRIF-dependent Toll-like receptor signaling suppresses Scd1 transcription in hepatocytes and prevents diet-induced hepatic steatosis. , Science Signaling. 2017, 10.

Li J., Woo W.H.C. and Xu A., Adiponectin antagonizes dietary-induced metabolic diseases via modulation of gut microbiota, Keystone Symposia: Manipulation of the Gut Microbiota for Metabolic Health. 2018.

Woo W.H.C., Xu A. and Li J., Faculty Research Output Prize, Li Ka Shing Faculty of Medicine, HKU. 2017.

Woo W.H.C., Fellow of American Heart Association, American Heart Association, Council on Arteriosclerosis, Thrombosis and Vascular Biology. 2017.

Woo W.H.C., Gut microbiome - Our life partner, for better or worse?, International Tropical Agriculture Conference 2017. 2017.

Woo W.H.C., Gut microbiota and we: Who is in charge? , R30 Reunion cum Scientific Conference in Winnipeg. 2018.

Woo W.H.C., Gut-derived flagellin promotes the production of apolipoprotein A1 in hepatocytes, Mouse Metabolic Phenotyping Center Seminar Series, University of Cincinnati . 2018.

YIU J.H.C., Li J., FUNG W.L., CHEUNG J., Tso P., Xu A. and Woo W.H.C., Gut microbiota facilitates apolipoprotein A1 and HDL production through hepatic TLR5, ATVB 2018 Scientific Session . 2018.

YIU J.H.C., Xu A. and Woo W.H.C., Maternal gut microbiota facilitates labyrinthine development in placenta, Keystone Symposium: Maternal-Fetal Crosstalk: Harmony vs. Conflict. 2017.

YIU J.H.C., Xu A. and Woo W.H.C., Maternal gut microbiota facilitates labyrinthine development in placenta, Maternal-Fetal Crosstalk: Harmony vs. Conflict, 4-8 Oct 2017, Westin Washington, DC City Center, Washington, DC, USA. 2017.

YIU J.H.C. and Woo W.H.C., The Best Poster Award, The 22th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine. 2017.

Researcher : Worsley AJ

List of Research Outputs

Chan L.K., Ganotice F.J.A., Wong F.K.Y., Lau W.C.S., Bridges S.M., Chan C.H.Y., Chan N.K., Chan W.L.P., Chen H., Chen J.Y., Chu K.P.J., Ho C.C., Ho J.M.C., Lam T.P., Lam S.F., Li Q., Shen J., Tanner J.A., Tso W.Y.W., Wong A.K.C., Wong G.T.C., Wong J.Y.H., Wong N.S., Worsley A.J., Yu L.K. and Yum T.P., Implementation of an interprofessional team-based learning program involving seven undergraduate health and social care programs from two universities, and students’ evaluation of their readiness for interprofessional learning, BMC Medical Education. 2017, 17.

Chen J.Y., Chin W.Y., Chan L.K., Tiwari A.F.Y., Wong J.Y.H., Worsley A.J., Feng Y., Sham M.H., Tsang J.P.Y. and Lau W.C.S., Free Paper Presentation - Poster Audience Award, Asian Medical Education Association. 2017.

Chen J.Y., Chin W.Y., Chan L.K., Tiwari A., Worsley A.J., Feng Y., Sham M.H., Tsang J.P.Y. and Lau W.C.S., Stress and its impact on learning: a snapshot of first year health sciences students in the Li Ka Shing Faculty of Medicine, Ninth Asia Medical Education Association Symposium cum Frontiers in Medical and Health Sciences Education . 2017.

Researcher : XU Y

List of Research Outputs

Raik S., Andranovitš S., Petrova V., XU Y., Lam J.K.W., Morris G., Brodskaia A., Casettari L., Kritchenkov A. and Skorik Y., Comparative Study of Diethylaminoethyl-Chitosan and Methylglycol-Chitosan as Potential Non-Viral Vectors for Gene Therapy, Polymers. 2018, 10: 442.

Researcher : Xu A

Project Title:	Molecular mechanism underlaying the pathogenesis of type 2 diabetes
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:	05/2007

Project Title:	Genetic and pathogenic pathways leading to type 2 diabetes Mellitus
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:	05/2011

Project Title:	71th Scientific Sessions of the American Diabetes Association Genetic Inactivation of Toll-Like Receptor 4 Alleviates Diet-Induced Nonalcoholic Steatohepatitis by Inhibiting Reactive Oxygen Species-Evoked Activation of X-box Binding Protein-1 in ApoE-Deficient Mice
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2011

Project Title:	Physical exercise promotes vascular health: impact of mechano-transduction and novel endothelium-derived regulators
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2013

Project Title:	Fibroblast growth factor 21 maintains glucose homeostasis during fasting by mediating the crosstalk between liver and brain
Investigator(s):	Xu A, Cheng KY
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014
Completion Date:	01/2018

Project Title:	Fatty acid binding protein-4 as a mediator of autoimmune diabetes: from molecular mechanism to clinical significance
Investigator(s):	Xu A, Lam KSL
Department:	Medicine
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2015

Project Title:	Interplay between Adiponectin and Alternatively-activated Macrophages in Cold-induced Remodeling and Adaptive Thermogenesis of White Adipose Tissues
Investigator(s):	Xu A, Hui X
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015
Completion Date:	12/2017

Project Title:	FGF21 resistance as a potential mediator of systemic insulin resistance and type 2 diabetes
Investigator(s):	Xu A, Lam KSL, Chan YCC
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	Development of innovative chemiluminescent immunoassays for diabetes and its cardiovascular complications
Investigator(s):	Xu A, Cheung BMY, Zhang J, Zhou P, Wang Y, Choi L
Department:	Medicine
Source(s) of Funding:	Matching Grant for Joint Research
Start Date:	04/2015

Project Title:	A Multi-disciplinary Approach to Investigate Vascular Dysfunction in Obesity and Diabetes: From Molecular Mechanism to Therapeutic Intervention
Investigator(s):	Xu A, Cheng KY, Lam KSL, Vanhoutte PMGR, Wang Y, Woo WHC, Wu EX
Department:	Medicine
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2015

Project Title:	2015 51st EASD Annual Meeting ; Adiponectin is required for adaptive thermogenesis by enhancing the browning of white adipose tissues in mice
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2015

Project Title:	Development of Innovative Chemiluminescent Immunoassays for Diabetes and its Cardiovascular Complications
Investigator(s):	Xu A, Cheung BMY, Zhang J, Zhou P, Wang Y, Choi L
Department:	Medicine
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	11/2015

Project Title:	Frontiers in Immunometabolism
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	Croucher Advanced Study Institute
Start Date:	11/2015

Project Title:	Neutrophil serine proteases as a potential mediator of insulitis in autoimmune diabetes
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	Brown adipose tissue as a new weapon against obesity-related vascular disorders
Investigator(s):	Xu A, Hui X
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2016
Completion Date:	04/2018

Project Title:	Deciphering the molecular mechanism of Protein Arginine Methyltransferase (PRMT) 1 in the regulation of hepatic glucose and lipid metabolism
Investigator(s):	Xu A, Woo WHC
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2016

Project Title:	FGF21 as a potential mediator for the anti-depressant effects of physical exercise
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2016

Project Title:	Activation of uncoupling protein-1 as a potential therapeutic strategy for obesity-induced endothelial dysfunction and atherosclerosis
Investigator(s):	Xu A, Vanhoutte PMGR
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2016

Project Title:	Fibroblast growth factor-21 as an Autocrine Regulator of Browning and Adaptive Thermogenesis in Subcutaneous Adipose Tissue
Investigator(s):	Xu A, Hui X
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

Project Title:	Vascular Dysfunction in Obestiy and Diabetes: From Molecular Mechanism to Therapeutic Intervention
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	Croucher Senior Research Fellowships in Natural Sciences, Technology and Medicine
Start Date:	01/2017
Completion Date:	01/2018

Project Title:	Development of an Innovative Immunoturbidimetric Assay (ITA) of Lipocalin-2 (LCN2) for Prognosis and Diagnosis of Diabetes and its Cardiovascular Complications
Investigator(s):	Xu A, Zhong L, Zhou P
Department:	Medicine
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	06/2017

Project Title:	Adiponectin antagonizes dietary obesity-induced metabolic dysfunction via modulation of gut microbiota
Investigator(s):	Xu A, Liu Y
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

Project Title:	Institute of Metabolic Medicine (AoE)
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	Seed Funding for Strategic Interdisciplinary Research Scheme
Start Date:	06/2017

Project Title:	A multi-disciplinary study on the beneficial effects of PPARD in physical exercise against diabetic vascular complications: cellular crosstalk and energy metabolism
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2017

Project Title:	UCP1 Independent Mechanisms Mediate the Crosstalk between Brown and White Adipose Tissue to Dissipate Energy
Investigator(s):	Xu A, Hui X
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2018

Project Title:	The mechanobiology of obesity
Investigator(s):	Xu A, Hui X, Wang B
Department:	Medicine
Source(s) of Funding:	France/Hong Kong Joint Research Scheme - Travel Grants
Start Date:	01/2018

Project Title:	A Multi-Channel Oxytherm System for Research into Mitochondria Respiration and Function
Investigator(s):	Xu A, Shen J, Chung SK, Hoo RLC, Hui X, Woo WHC
Department:	Medicine
Source(s) of Funding:	Small Equipment Grant
Start Date:	04/2018

Project Title:	Hepatic G protein-coupled receptor 110 as a potential therapeutic target to combat obesity and its related metabolic complications
Investigator(s):	Xu A, Huang Z
Department:	Medicine
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2018

Project Title:	Conversion of white into brown adipocytes as a therapeutic strategy for obesity-related metabolic and vascular complications
Investigator(s):	Xu A, Hoo RLC, Hui X, Vanhoutte PMGR, Wang Y, Woo WHC
Department:	Medicine
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2018

List of Research Outputs

YIU J.H.C., Li J., FUNG W.L., CHEUNG J., Tso P., Xu A. and Woo W.H.C., Gut microbiota facilitates apolipoprotein A1 and HDL production through hepatic TLR5, ATVB 2018 Scientific Session . 2018.

YIU J.H.C., Xu A. and Woo W.H.C., Maternal gut microbiota facilitates labyrinthine development in placenta, Keystone Symposium: Maternal-Fetal Crosstalk: Harmony vs. Conflict. 2017.

Researcher : Xu C

List of Research Outputs

Hampe L., Xu C., Harris P.W., CHEN J., LIU M., Middleditch M., Radjainia M., Wang Y. and Mitra A.K., Obesity-related metabolic disorders mitigated by peptides designed to modulate adiponectin assembly, British Journal of Pharmacology. 2017.

Researcher : YIU JHC

List of Research Outputs

Chen J., Li J., Yiu J.H.C., Lam J.K.W., Wong C.M., Xu A. and Woo W.H.C., TRIF-dependent Toll-like receptor signaling suppresses Scd1 transcription in hepatocytes and prevents diet-induced hepatic steatosis. , Science Signaling. 2017, 10.

YIU J.H.C., Li J., FUNG W.L., CHEUNG J., Tso P., Xu A. and Woo W.H.C., Gut microbiota facilitates apolipoprotein A1 and HDL production through hepatic TLR5, ATVB 2018 Scientific Session . 2018.

YIU J.H.C., Maternal gut microbiota facilitates labyrinthine development in placenta, 22nd Research Postgraduate Symposium, 6-7 Dec 2017, Hong Kong. 2017.

YIU J.H.C., Xu A. and Woo W.H.C., Maternal gut microbiota facilitates labyrinthine development in placenta, Keystone Symposium: Maternal-Fetal Crosstalk: Harmony vs. Conflict. 2017.

YIU J.H.C., Xu A. and Woo W.H.C., Maternal gut microbiota facilitates labyrinthine development in placenta, Maternal-Fetal Crosstalk: Harmony vs. Conflict, 4-8 Oct 2017, Westin Washington, DC City Center, Washington, DC, USA. 2017.

YIU J.H.C. and Woo W.H.C., The Best Poster Award, The 22th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine. 2017.

Researcher : ZHOU Y

List of Research Outputs

ZHOU Y., CHENG K.K.Y., Xu A. and Hoo R.L.C., Metabolic Profiling of Serum Reveals Significant Changes in Lipid and Amino Acid Metabolism in a Lipodystrophy Mouse Model, EXPERIMENTAL BIOLOGY 2018, 21-25 Apr 2018, San Diego, California. 2018.

Researcher : Zhao J

List of Research Outputs

Zhao J., Schooling C.M. and Zhao J., The effects of folate supplementation on glucose metabolism and risk of type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials, Annals of Epidemiology. 2018, 28: 249-257.e1.

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