Dept of Pharmacology & Pharmacy

DEPT OF PHARMACOLOGY & PHARMACY

Researcher : Anand S

List of Research Outputs

He Y., Chan E.W., Leung W.K., Anand S. and Wong I.C.K., Systematic review with meta-analysis: the association between the use of calcium channel blockers and gastrointestinal bleeding, Alimentary Pharmacology & Therapeutics. 2015, 41: 1246-1255.

Researcher : BAI B

List of Research Outputs

BAI B., MAN W.C., Liang Y., Deng H., LI J., Wang Y. and Vanhoutte P.M.G.R., Molecular dissection of the interplay between SIRT1, LKB1 and HERC2: linkage implication in endothelial senescence and vascular remodeling, 11th International Symposium on Resistance Arteries, September 7-11, 2014, Banff, Canada. 2014.

Bai B., MAN W.C., LIANG Y., Deng H., LI J., Vanhoutte P.M.G.R. and Wang Y., Molecular dissection of the interplay between SIRT1, LKB1 and HERC2: linkage implication in endothelial senescence and vascular remodeling , The 11th International Symposium on Resistance Arteries. SWITZERLAND, KARGER, 2014, 51(S2).

Xu C., CAI Y., Fan P., Bai B., CHEN J., Deng H., Che C.M., Xu A., Vanhoutte P.M.G.R. and Wang Y., Calorie Restriction Prevents Metabolic Aging Caused by Abnormal SIRT1 Function in Adipose Tissues, Diabetes. 2015, 64: 1576-1590.

Researcher : BARETELLA OM

List of Research Outputs

BARETELLA O.M., Xu A. and Vanhoutte P.M.G.R., Interaction between IP, TP, and 5-HT₂ receptors during contractions to prostacyclin in rat renal arteries, ASCEPT-BPS Joint Scientific Meeting, Tomorrow's medicines: pharmacology, patients and populations, May 19-21, 2015, Hong Kong. 2015.

BARETELLA O.M., Xu A. and Vanhoutte P.M.G.R., Prostagiandin 12 Receptor blockade Contracts Rat Renal Arteries and Facilitates Endothelium-Dependent Contractions, High Blood Pressure Research 2014, September 9-12, 2014 San Francisco, CA. 2014.

BARETELLA O.M., Xu A. and Vanhoutte P.M.G.R., Role of IP receptors in renal basal arterial tone and endothelium-dependent contractions, Eighteenth Annual Scientific Meeting, Institute of Cardiovascular Science and Medicine, November 1, 2014, Hong Kong. 2014.

Baretella O.M., Xu A. and Vanhoutte P.M.G.R., Increase in vasomotor tone upon IP receptor blockade in isolated murine renal arteries-role of lipoxygenase(s), 17th World Congress of Basic & Clinical Pharmacology, July 13-18, 2014, Cape Town, South Africa. 2014.

Researcher : Bai B

List of Research Outputs

Researcher : Baretella OM

List of Research Outputs

Researcher : CAI Y

List of Research Outputs

CAI Y., 2nd Prize of an outstanding Oral Presentation at the 18th Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine, November 1, 2014., 2014.

CAI Y., Vanhoutte P.M.G.R. and Tang E.H.C., Repressor activator protein 1 induces pro-inflammatory cytokines production in macrophages through NFKB signaling, Eighteenth Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine. 2014.

CAI Y., Xu C. and Wang Y., Role of adiponectin in SIRT1-mediated mitochondrial regulation in adipose tissue, The international conference “DNSG 2015: 33rd International Symposium on Diabetes & Nutrition” in Toronto, Canada, June 9-12, 2015.

CAI Y., SIRT1 enhances lipid storage and utilization in adipose tissues by promoting mitophagy: role of adiponectin, 19th Research Postgraduate Symposium, December 10, 2014, Hong Kong. 2014.

CAI Y., Li M. and Wang Y., SIRT1 enhances lipid storage and utillzation in adipose tissues by promoting mitophagy: Role of adiponectin, System Approach to Metabolic Diseases, October 1-3, 2014, Chicago, IL, USA. 2014.

CAI Y., MANIO M.M., Leung G.P.H., Xu A., Tang E.H.C. and Vanhoutte P.M.G.R., Thyroid hormone affects both endothelial and vascular smooth muscle cells in rat arteries, European Journal of Pharmacology. 2015, 747: 18-28.

Tang E.H.C., Cai Y., Wong C.K., Rocha V.Z., Sukhova G.K., Shimizu K., GE X., Vanhoutte P.M.G.R., Libby P. and Xu A., Activation of prostaglandin E2-EP4 signaling reduces chemokine production in adipose tissue , Journal of Lipid Research. 2015, 56(2): 358-368.

WONG H.K., Cai Y. and Tang E.H.C., Knockdown of repressor activator protein 1 facilitated foam cell formation by augmenting cholesterol uptake, Eighteenth Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine " Bridging the Translational Gap", 1 November 2014, Hong Kong 2014.

WONG H.K., Cai Y. and Tang E.H.C., Repressor activator protein 1 suppresses foam cell formation by reducing acetylated or oxidized low-density lipoprotein cholesterol uptake, The Crossroads of Lipid Metabolism and Diabetes, Keystone Symposia on Molecular and Cellular Biology, April 19-24, 2015.

Xu C., CAI Y., Fan P., Bai B., CHEN J., Deng H., Che C.M., Xu A., Vanhoutte P.M.G.R. and Wang Y., Calorie Restriction Prevents Metabolic Aging Caused by Abnormal SIRT1 Function in Adipose Tissues, Diabetes. 2015, 64: 1576-1590.

YING F., Cai Y. and Tang E.H.C., Impaired cold tolerance in EP4 knockout mice is not due to compromised recruitment of UCP1, Eighteen Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine. 2014.

YING F., Cai Y. and Tang E.H.C., Prostaglandin E receptor subtype 4 (EP4) suppress CL316243-induced white adipose tissue remodeling without up-registration of UCP1, The Crossroads of Lipid Metabolism and Diabetes, Keystone Symposia on Molecular and Cellular Biology, April 19-24, 2015, Copenhagen, Denmark. 2015.

Researcher : CAI Y

List of Research Outputs

CAI Y., 2nd Prize of an outstanding Oral Presentation at the 18th Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine, November 1, 2014., 2014.

CAI Y., SIRT1 enhances lipid storage and utilization in adipose tissues by promoting mitophagy: role of adiponectin, 19th Research Postgraduate Symposium, December 10, 2014, Hong Kong. 2014.

Researcher : CHEN H

List of Research Outputs

CHEN H., Acute treatments with WY14643 and fenofibrate reduce acetylcholine-induced contractions in aortae from spontaneously hypertensive rats, 19th Research Postgraduate Symposium, December 10, 2014, Hong Kong. 2014.

CHEN H., Leung S.W.S. and Man R.Y.K., Effect of Wy14643 and fenofibrate on acetylcholine-induced contractions in aortic rings from spontaneously hypertensive rats, Eighteenth Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine “Bridging Translational Gap”, 1 Nov 2014, Hong Kong. 2014.

CHEN H., Leung S.W.S. and Man R.Y.K., Wy14643 and fenofibrate reduce acetylcholine-induced contractions in spontaneously hypertensive rat aortae, American Heart Association's Arteriosclerosis, Thrombosis and Vascular Biology 2015 Scientific Sessions, 7 to 9 May 2015, San Francisco, CA, USA. 2015.

CHEN H., Leung S.W.S. and Man R.Y.K., Wy14643 and fenofibrate reduce contractions to hydrogen peroxide in aortae of spontaneously hypertensive rats, ASCEPT-BPS Joint Scientific Meeting "Tomorrow's medicines: pharmacology, patients and populations”, 19-21 May 2015, Hong Kong. 2015.

Researcher : CHEN J

List of Research Outputs

CHEN J., Xu A. and Woo W.H.C., Regulation of Lipogenesis by Toll like receptor pathway: Effect on Stearyl-CoA Desaturase-1, Tenth International Symposium on Healthy Aging, "A Decade of Positive Aging", March 7-8, 2015, Hong Kong. 2015.

CHEN J., Young Investigator Award (Poster Category), Tenth International Symposium on Healthy Aging "A Decade of Positive Aging" March 7-8, 2015, 2015.

Xu C., CAI Y., Fan P., Bai B., CHEN J., Deng H., Che C.M., Xu A., Vanhoutte P.M.G.R. and Wang Y., Calorie Restriction Prevents Metabolic Aging Caused by Abnormal SIRT1 Function in Adipose Tissues, Diabetes. 2015, 64: 1576-1590.

Researcher : CHEN J

List of Research Outputs

CHEN J., Young Investigator Award (Poster Category), Tenth International Symposium on Healthy Aging "A Decade of Positive Aging" March 7-8, 2015, 2015.

Researcher : CHEN S

List of Research Outputs

CHEN S., Mak J.C.W., Tong H.H.Y. and Kwok P.C.L., Inhalable Oleanolic Acid-Hypromellose Particles for Controlled Release, 40th Micro and Nano Engineering 2014, Lausanne, Switzerland, September 22-26, 2014.

CHEN S., Inhalable oleanolic acid-hypromellose particles for controlled release, 19th Research Postgraduate Symposium, December 10, 2014, Hong Kong. 2014.

Researcher : CHEONG LY

List of Research Outputs

SHU L., WU X., CHEONG L.Y., Zhou M., Lam K.S.L., Xu A. and Hoo R.L.C., Adipocyte fatty acid binding protein (A-FABP) is a potential regulator of adaptive thermogenesis, Tenth international symposium on healthy aging"A decade of positive aging ". 2015.

Researcher : CHEUNG C

List of Research Outputs

CHEUNG C., Cheung K.H. and Leung G.P.H., Mechanisms of action of Xinmailong, a Chinese Medicine derived from Periplaneta Americana, in treating heart failure, 17th World Congress of Basic and Clinical Pharmacology 2014, Cape Town, South Africa from 13-18 July 2014.

CHEUNG C., Mechanisms of action of xinmailong, a Chinese medicine derived from periplaneta Americana, in treating heart failure, 17th World Congress of Basic & Clinical Pharmacology, July 13-18, 2014, Cape Town, South Africa. 2014.

Researcher : CHOW YT

List of Research Outputs

LIANG W., CHOW Y.T., Lau P.N., Zhou Q.T., Kwok P.C.L., Leung G.P.H., Mason A.J.M., Chan H.K., Poon L.L.M. and Lam J.K.W., Inhalable powder formulations of siRNA and pH responsive peptides with antiviral activity against H1N1 influenza virus, Molecular Pharmaceutics. 2015, 12: 910-921.

Researcher : CHUI SLC

List of Research Outputs

CHUI S.L.C., Man K.C.K., Cheng C.L., LAU C.Y., Cheng V.C.C., Wong D.S.H., Yan-Kao Y.H. and Wong I.C.K., An investigation of the association between retinal detachment and oral fluoroquinolones: a self-controlled case series study. , International Society of Pharmacovigilance XIII meeting, Pisa, October 1-4 International Society for Pharmacoepidemiology (ISPE) 8th Asian Conference on Pharmacoepidemiology; The University of Hong Kong, 25-27 October. 2014.

CHUI S.L.C., Wong I.C.K., Wong L.Y.L. and Chan E.W., Association between oral fluoroquinolone use and the development of retinal detachment: a systematic review and meta-analysis of observational studies, J Antimicrob Chemother. 2015, 70(4): 971-78.

CHUI S.L.C., First Poster Prize at the 14th Annual Meeting of the International Society of Pharmacovigilance, October 19-22, 2014, Tianjin, China, 2014.

CHUI S.L.C., Roche Postgraduate Research Student Prize, 2015.

CHUI S.L.C., Wong I.C.K., Wong L.Y.L. and Chan E.W., The association between oral fluoroquinolone use and the development of retinal detachment: a systematic review and meta-analysis of observational studies, ISOP 2014, Tianjin, China, 19-22 October (poster). 2014.

CHUI S.L.C., Chan E.W., WONG Y.S. and Wong I.C.K., The association between oral fluoroquinolones and incident seizure event, 30th ICPE, Taipei, Taiwan, 24-27 October (poster). 2014.

HE Y., WONG Y.S., Chan E.W., LAU C.Y., Man K.C.K., CHUI S.L.C., Worsley A.J. and Wong I.C.K., Safety of tofacitinib in the treatment of rheumatoid arthritis: a systematic review and meta-analysis, International Society of Pharmacovigilance XIII meeting, Pisa, October 1-4, International Society for Pharmacoepidemiology (ISPE) 8th Asian Conference on Pharmacoepidemiology; The University of Hong Kong, 25-27 October. 2014.

Lai E.C.C., Man K.C.K., Chaiyakunapruk N., Cheng C.L., Chien H.C., CHUI S.L.C., Dilokthornsakul P., Chantelle H.N., Hsieh C.Y. and Hsu C.Y., Databases in the Asia-Pacific Region:The Potential for a Distributed Network Approach, Epidemiology. 2015, 1.

Man K.C.K., Ip P., Hsia Y., Chan E.W., Chui S.L.C., Lam M.P.S., Wong W.H.S., Chow C.B., Yung A.W.Y. and Wong I.C.K., ADHD Drug Prescribing Trend Is Increasing Among Children and Adolescents in Hong Kong, Journal of Attention Disorders published online 3 July 2014. 2014.

Researcher : Cai Y

List of Research Outputs

CAI Y., 2nd Prize of an outstanding Oral Presentation at the 18th Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine, November 1, 2014., 2014.

CAI Y., SIRT1 enhances lipid storage and utilization in adipose tissues by promoting mitophagy: role of adiponectin, 19th Research Postgraduate Symposium, December 10, 2014, Hong Kong. 2014.

Researcher : Chan EW

Project Title:	Intramuscular olanzapine versus haloperidol or midazolam for the management of acute agitation in the emergency department a multicentre randomised clinical trial.
Investigator(s):	Chan EW
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	01/2014

Project Title:	Young adult patient experiences in clinical management of ADHD in Hong Kong
Investigator(s):	Chan EW
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Janssen Pharmaceutica - General Award
Start Date:	01/2014

Project Title:	Australasian College for Emergency Medicine; MANAGEMENT OF ACUTE AGITATION IN THE ACCIDENT AND EMERGENCY SETTING: A SURVEY OF PRACTICE IN HONG KONG
Investigator(s):	Chan EW
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	12/2014

Project Title:	Pharmacoepidemiology of oral anticoagulation agents a comparison of dabigatran etexilate, warfarin and dual-antiplatelet therapy in patients with atrial fibrillation.
Investigator(s):	Chan EW, Cheung BMY, Leung WK, Wong ICK
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Cardiovascular outcomes associated with use of clarithromycin
Investigator(s):	Chan EW, Wong ICK
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Small Project Funding
Start Date:	06/2015

List of Research Outputs

CHUI S.L.C., Wong I.C.K., Wong L.Y.L. and Chan E.W., Association between oral fluoroquinolone use and the development of retinal detachment: a systematic review and meta-analysis of observational studies, J Antimicrob Chemother. 2015, 70(4): 971-78.

CHUI S.L.C., Wong I.C.K., Wong L.Y.L. and Chan E.W., The association between oral fluoroquinolone use and the development of retinal detachment: a systematic review and meta-analysis of observational studies, ISOP 2014, Tianjin, China, 19-22 October (poster). 2014.

CHUI S.L.C., Chan E.W., WONG Y.S. and Wong I.C.K., The association between oral fluoroquinolones and incident seizure event, 30th ICPE, Taipei, Taiwan, 24-27 October (poster). 2014.

Chan E.W., A survey study to investigate attitudes and perceptions of Chinese medicine professionals in the use of health information technology in Hong Kong. ISOP, Tianjin. (Declined due to teaching responsibilities)., 2014.

Chan E.W. and Collaboration A.S.P.E.N., Databases in Asia/Pacific region: The Potential for Distributed Network Approach. , 30th ICPE, Taipei, Taiwan, 24-27 October (poster).. 2014.

Chan E.W., LAU C.Y., Leung W.K., Mok M.T.C., HE Y., Tong T.S.M. and Wong I.C.K., Effectiveness of Gastroprotective Agents on Prevention of Dabigatran Related Gastrointestinal Bleeding: A Population-Based Restrospective Cohort Study, ISOP 2014, Tianjin, China, 19-22 October (oral). 2014.

Chan E.W., LAU C.Y., Leung W.K., Mok T.C., HE Y., Tong S.M. and Wong I.C.K., Effectiveness of gastroprotective agents on prevention of dabigatran related gastrointestinal bleeding: a population-based retrospective cobort study, 14th ISoP Annual Meeting "New Ideas in Ancient Cultures: Advancing Pharmacovigilance in Asia", 19-22 October 2014, Tianjin China. 2014.

Chan E.W., Lau C.Y., Leung W.K., Mok M.T.C., He Y., Tong S.M. and Wong I.C.K., Prevention of Dabigatran-related Gastrointestinal Bleeding With Gastroprotective Agents: A Population-Based Study, Gastroenterology. 2015.

Cheung K.K.W., Wong I.C.K., Ip P., Chan P.K.L., Lin H.Y.C., Wong L.Y.L. and Chan E.W., Experiences of adolescents and young adults with ADHD in Hong Kong: treatment services and clinical management, BMC Psychiatry. 2015, 15(1): 95.

HE Y., Chan E.W., Man K.C.K., LAU C.Y., Leung W.K., Ho L.M. and Wong I.C.K., Dosage Effects of Histamine-2 Receptor Antagonist on the Primary Prophylaxis of Non-Steroidal Anti-Inflammatory Drug (NSAID)-Associated Peptic Ulcers: A Retrospective Cohort Study, Drug Safety. 2014, 37: 711-721.

HE Y., WONG Y.S., Chan E.W., LAU C.Y., Man K.C.K., CHUI S.L.C., Worsley A.J. and Wong I.C.K., Safety of tofacitinib in the treatment of rheumatoid arthritis: a systematic review and meta-analysis, International Society of Pharmacovigilance XIII meeting, Pisa, October 1-4, International Society for Pharmacoepidemiology (ISPE) 8th Asian Conference on Pharmacoepidemiology; The University of Hong Kong, 25-27 October. 2014.

He Y., Chan E.W., Leung W.K., Anand S. and Wong I.C.K., Systematic review with meta-analysis: the association between the use of calcium channel blockers and gastrointestinal bleeding, Alimentary Pharmacology & Therapeutics. 2015, 41: 1246-1255.

Ho M.H., Ho C.W., Cheung E., Chan P.H.M., Hai J.J., Chan K.H., Chan E.W., Leung G.K.K., Tse H.F. and Siu D.C.W., Continuation of Dabigatran Therapy in “Real-World” Practice in Hong Kong, PLoS ONE. 2014, 9(8): e101245.

Hsu W.W.Q., Chan E.W., Zhang Z., Lin Z.X., Bian Z.X., Hsia Y. and Wong I.C.K., A survey to investigate attitudes and perceptions of Chinese medicine professionals in health information technology in Hong Kong, Eur J Integr Med. 2015, 7(1): 36-46.

Hsu W.W.Q., Chan E.W., Zhang Z., Lin Z.X., Bian Z.X. and Wong I.C.K., Chinese medicine students’ view on electronic prescribing: A survey in Hong Kong, Eur J Integr Med. 2015, 7(1): 47-54.

LAU C.Y., Chan E.W., Liu K. and Wong I.C.K., The Unmet Needs of Antithrombotic Treatment in Patients with Non-Valvular Atrial Fibrillation in Real-World Clinical Practice, ISOP 2014, Tianjin, China, 19-22 October (oral). 2014.

LAU C.Y., Chan E.W., Wong I.C.K., HE Y., Tong S.M. and Leung W.K., Use of gastroprotective agents and risk of dabigatran associated gastrointestinal bleeding: a population-based retrospective cohort study, United European Gastroenterology (UEG) Week,18-22 October, Vienna. 2014.

Leung A.Y.M., Lau P.H.F., Chau P.H. and Chan E.W., Multiple-choice version of Chinese Health Literacy Scale for Diabetes (CHLSD): A Validation Study, 2014 Health Literacy Research Conference. 2014.

Liu K.Q.L., Lu H.P., Gong J.R., Wong I.C.K. and Chan E.W., Feasibility of Pharmacist-participated Anticoagulation Management Service (PAMS) in A Regional Hospital in Shanghai: a Pilot Study, ISOP 2014, Tianjin, China, 19-22 October (poster). 2014.

Man K.C.K., Ip P., Hsia Y., Chan E.W., Chui S.L.C., Lam M.P.S., Wong W.H.S., Chow C.B., Yung A.W.Y. and Wong I.C.K., ADHD Drug Prescribing Trend Is Increasing Among Children and Adolescents in Hong Kong, Journal of Attention Disorders published online 3 July 2014. 2014.

Man K.C.K., Chan E.W., Douglas I., Ip P., Wong W.H.S., Coghill D. and Wong I.C.K., Attention-Deficit/Hyperactivity Disorder (ADHD) Pharmacological Treatment and Its Effect on Accident and Emergency Admission Due to Injury: A Self-Controlled Case-Series Study, 30th International Conference for Pharmacoepidemiology (ICPE). 2014.

Man K.C.K., Tong H.Y.H., Wong L.Y.L., Chan E.W., Simonoff E. and Wong I.C.K., Exposure to selective serotonin reuptake inhibitors during pregnancy and risk of autism spectrum disorder in children: A systematic review and meta-analysis of observational studies, Neuroscience & Biobehavioral Reviews. 2014, 49: 82-89.

Man K.C.K., Chan E.W., Coghill D., Douglas I., Ip P., Leung L.P., Tsui M.S.H., Wong W.H.S. and Wong I.C.K., Methylphenidate and the Risk of Trauma, PEDIATRICS. 2014, 135(1): 40-48.

Pratt N., Chan E.W., Choi N.K., Kimura M., Kimura T., Kubota K., Lai E.C.C., Man K.C.K., Ooba N., Park B.J., Sato T., Shin J.Y., Wong I.C.K., Kao Yang Y.H. and Roughead E.E., Prescription sequence symmetry analysis: assessing risk, temporality, and consistency for adverse drug reactions across datasets in five countries, Pharmacoepidemiology and Drug Safety. 2015, 24.

WONG Y.S., Hsia Y.F., Chan E.W., Murphy D.G., Simonoff E., Buitelaar J.K. and Wong I.C.K., The variation of psychopharmacological treatment for people with autistic spectrum disorder (ASD): an international study, International Society for Pharmacoepidemiology (ISPE) 8th Asian Conference on Pharmacoepidemiology; The University of Hong Kong. 2014.

Researcher : Chan HK

List of Research Outputs

Kwok P.C.L. and Chan H.K., Drug nanoparticles: Production, dissolution, and pulmonary drug delivery, 17th International Pharmaceutical Technology Symposium, Antalya, Turkey, 8 – 10 September 2014. 2014, 95.

Wong J., Kwok P.C.L., Noakes T., Fathi A., Dehghani F. and Chan H.K., Effect of crystallinity on electrostatic charging in dry powder inhaler formulations, Pharmaceutical Research. Springer US, 2014, 31: 1656-1664.

Researcher : Chan WLP

List of Research Outputs

Chan W.L.P., HKU Master of Clinical Pharmacy - A Novel Teaching Model, International Clinical Pharmacy Symposium 2015. 2015.

Chan W.L.P., Teaching of Clinical Pharmacy in HKU, 香港大學臨床藥劑及實踐培訓, Chinese Pharmaceutical University. 中國藥科大學, 2014.

Researcher : Chan WYE

Project Title:	Intramuscular olanzapine versus haloperidol or midazolam for the management of acute agitation in the emergency department a multicentre randomised clinical trial.
Investigator(s):	Chan EW
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	01/2014

Project Title:	Young adult patient experiences in clinical management of ADHD in Hong Kong
Investigator(s):	Chan EW
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Janssen Pharmaceutica - General Award
Start Date:	01/2014

Project Title:	Australasian College for Emergency Medicine; MANAGEMENT OF ACUTE AGITATION IN THE ACCIDENT AND EMERGENCY SETTING: A SURVEY OF PRACTICE IN HONG KONG
Investigator(s):	Chan EW
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	12/2014

Project Title:	Pharmacoepidemiology of oral anticoagulation agents a comparison of dabigatran etexilate, warfarin and dual-antiplatelet therapy in patients with atrial fibrillation.
Investigator(s):	Chan EW, Cheung BMY, Leung WK, Wong ICK
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Cardiovascular outcomes associated with use of clarithromycin
Investigator(s):	Chan EW, Wong ICK
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Small Project Funding
Start Date:	06/2015

List of Research Outputs

Researcher : Cheung CL

Project Title:	Identification of susceptibility locus of Stevens-Johnson Syndrome and Toxic Epidermal Necrosis in Hong Kong Chinese
Investigator(s):	Cheung CL, Cheung BMY, Wong ICK, Sham PC, Chan CYJ
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2013

Project Title:	Epidemiological study of serious adverse drug reactions in Hong Kong
Investigator(s):	Cheung CL
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

Project Title:	Genetics and genomics of anti-thyroid drug induced agranulocytosis
Investigator(s):	Cheung CL, Kung AWC, Tan KCB, Sham PC, Wong ICK
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	The role of Vitamin D and bone metabolism in cardiovascular events risk, an interaction or mediation? An 11 year follow-up study
Investigator(s):	Cheung CL, Tan KCB, Kung AWC, Cheung BMY
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	02/2015

List of Research Outputs

Cheung C.L., Adverse drug reaction due to genetic variants, Hospital Authority commission training: Clinical Genetics - from bed side to bench side and back to bed side. 2015.

Cheung T.T., Cheung C.L., Tan K.C.B., Leung Y.H. and Cheung B.M.Y., People With Peripheral Arterial Disease And Diabetes Are Associated With Clinically Significant Weakness , International conference on diabetes and metabolism. 2014.

Li R.H.W., Cheung C.L., Tan K.C.B., Sham P.C., Kung A.W.C. and Tang G.W.K., Replication study of genetic loci influencing age at menopause in Southern Chinese women., The 10th European Congress on Menopause and Andropause, Madrid, May 2015.

SING C.W. and Cheung C.L., 20th Medical Research Conference, January 17, 2015, Hong Kong, Drug-induced agranulocytosis in Southern Chinese population: a twelve-year retrospective study. 2015.

SING C.W., Cheung C.L., Lam K.S.L. and Cheung B.M.Y., Low lean mass and gait speed in people with both diabetes and peripheral arterial disease, Tenth International Symposium on Healthy Aging, " A Decade of Positive Aging" March 7-8, 2015, Hong Kong. 2015.

SING C.W., Cheung C.L., Cheung B.M.Y., Wong I.C.K. and Chan C.Y.J., Toxic epidermal necrolysis: clinical profile in a tertiary hospital over a 15-year period, 19th Research Postgraduate Symposium, December 11, 2014, Hong Kong. 2014.

Sing C.W., Lui V.W.Y., Sham P.C., Tan K.C.B., Kung A.W.C., Wong I.C.K., Cheung B.M.Y., Chan J.C.Y. and Cheung C.L., JAG1 Polymorphism is Associated with Incident Neoplasm., 23rd Annual International Genetic Epidemiology Society, Vienna, Aug 2014.

Researcher : Cho CH

Project Title:	Advances in GI Pharmacology - From Acid Secretion to Mucosal Protection Symposium Non-ulcerogenic Dose of Dexamethasone Delays Gastric Ulcer Healing in Rats
Investigator(s):	Cho CH
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2004

Project Title:	Adrenaline and its receptor activation on colon cancer growth
Investigator(s):	Cho CH
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2006

Researcher : Chui SLC

List of Research Outputs

CHUI S.L.C., First Poster Prize at the 14th Annual Meeting of the International Society of Pharmacovigilance, October 19-22, 2014, Tianjin, China, 2014.

CHUI S.L.C., Roche Postgraduate Research Student Prize, 2015.

CHUI S.L.C., Chan E.W., WONG Y.S. and Wong I.C.K., The association between oral fluoroquinolones and incident seizure event, 30th ICPE, Taipei, Taiwan, 24-27 October (poster). 2014.

Researcher : DETREMMERIE CMS

List of Research Outputs

DETREMMERIE C.M.S., 1st Prize of an outstanding Oral Presentation at the 18th Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine, November 1, 2014., 2014.

DETREMMERIE C.M.S., Counterintuitive endothelium-soluble guanylyl cyclase-dependent contractions in isolated arteries, 19th Research Postgraduate Symposium, December 10, 2014, Hong Kong. 2014.

DETREMMERIE C.M.S., Leung S.W.S., Xu A., Gao Y. and Vanhoutte P.M.G.R., Endothelium-, soluble guanylyl cyclase-dependent contractions in isolated arteries, Eighteenth Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine “Bridging Translational Gap”, 1 Nov 2014, Hong Kong. 2014.

DETREMMERIE C.M.S., Leung S.W.S., Xu A., Gao Y. and Vanhoutte P.M.G.R., Endothelium-dependent vasoconstrictor signals requiring activation of soluble guanylyl cyclase in isolated arteries, ASCEPT-BPS Joint Scientific Meeting "Tomorrow's medicines: pharmacology, patients and populations" 2015, 19-21 May 2015, Hong Kong. 2015.

DETREMMERIE C.M.S., Leung S.W.S., Xu A., Alkharfy K., Gao Y. and Vanhoutte P.M.G.R., Thymoquinone as a pharmacological tool to study the endothelium-dependent, soluble guanylyl cyclase-dependent augmentation caused by hypoxia in isolated arteries , 17th World Congress of Basic and Clinical Pharmacology, 13 to 18 July, 2014, Cape Town, South Africa. 2014.

Researcher : Deng H

Project Title:	Does adiponectin facilitate the detoxification of oxidised low density lipoprotein in adipose tissue through clusterin (ApoJ)?
Investigator(s):	Deng H, Wang Y
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Small Project Funding
Start Date:	03/2015
Completion Date:	02/2016

Project Title:	83rd European Atherosclerosis Society Congress; Reduced clusterin (apo J) content of low density lipoproteins contributes to endothelial dysfunction in adiponectin deficient mice
Investigator(s):	Deng H
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2015
Completion Date:	03/2015

List of Research Outputs

BAI B., MAN W.C., Liang Y., Deng H., LI J., Wang Y. and Vanhoutte P.M.G.R., Molecular dissection of the interplay between SIRT1, LKB1 and HERC2: linkage implication in endothelial senescence and vascular remodeling, 11th International Symposium on Resistance Arteries, September 7-11, 2014, Banff, Canada. 2014.

Bai B., MAN W.C., LIANG Y., Deng H., LI J., Vanhoutte P.M.G.R. and Wang Y., Molecular dissection of the interplay between SIRT1, LKB1 and HERC2: linkage implication in endothelial senescence and vascular remodeling , The 11th International Symposium on Resistance Arteries. SWITZERLAND, KARGER, 2014, 51(S2).

Deng H., Huang B., Xu C., Park S., Xu A., Lee I.K. and Wang Y., Reduced Clusterin Contents Contribute to The Pro-Inflammatory and Pro-Senescent Activity of Low Density Lipoprotein Particles in Adiponectin Deficient Mice, The 9th Congress of the Asian-Pacific Society of Atherosclerosis and Vascular Disease and 16th Diabetes and Cardiovascular Risk Factor – East Meets West Symposium. Japan, Japan Atherosclerosis Society, 2014, 21: S34.

Deng H., Reviewer, PLOS ONE. UNITED STATES, PUBLIC LIBRARY SCIENCE, 2015.

Song E., Fan P., Huang B., Deng H., Feletou M., Vilaine J.P., Villeneuve N., Xu A., Vanhoutte P.M.G.R. and Wang Y., Linoleic Acid induced Activation of Lipocalin-2 Causes Endothelial Dysfunction and Hypertension in Obese Mice, U21 Graduate Research Conference 2014 Celebrating Ageing Research, University of Auckland, New Zealand, July 1-4, 2014.

Xu C., CAI Y., Fan P., Bai B., CHEN J., Deng H., Che C.M., Xu A., Vanhoutte P.M.G.R. and Wang Y., Calorie Restriction Prevents Metabolic Aging Caused by Abnormal SIRT1 Function in Adipose Tissues, Diabetes. 2015, 64: 1576-1590.

Zeng W.W., Deng H., Chu T.T.W., Fok B.S.P., Hu M. and Tomlinson B., Bisoprolol in essential hypertension: effects on 24 hour ambulatory blood pressure and metabolic profile in Chinese patients, The 9th Congress of the Asian-Pacific Society of Atherosclerosis and Vascular Disease and 16th Diabetes and Cardiovascular Risk Factor – East Meets West Symposium. Japan, Japan Atherosclerosis Society, 2014, 21: S9.

Researcher : Dufay S

Project Title:	Quantitation of Dexmedetomidine in plasma for pharmacokinetic study after intranasal administration in healthy volunteers
Investigator(s):	Dufay S, Irwin MG, Wong ICK
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2013

List of Research Outputs

Dufay S., Worsley A.J., Monteillier A., Avanzi C., Sy L.K., Ng T.F., Garcia J.M., Lam M.F., Vanhoutte P.M.G.R. and Wong I.C.K., Herbal tea extracts inhibit Cytochrome P450 3A4 in vitro, Journal of Pharmacy and Pharmacology. 2014, 66: 1478-1490.

Researcher : Fan P

List of Research Outputs

Li M., Fan P. and Wang Y., Integrative Approaches for Lipid Analysis, Pharmacologia. 2015.

Li M., Fan P. and Wang Y., Lipidomics in Health and Diseases - Beyond the Analysis of Lipids, Journal of Glycomics & Lipidomics. 2014.

Song E., Fan P., Huang B., Deng H., Feletou M., Vilaine J.P., Villeneuve N., Xu A., Vanhoutte P.M.G.R. and Wang Y., Linoleic Acid induced Activation of Lipocalin-2 Causes Endothelial Dysfunction and Hypertension in Obese Mice, U21 Graduate Research Conference 2014 Celebrating Ageing Research, University of Auckland, New Zealand, July 1-4, 2014.

Xu C., CAI Y., Fan P., Bai B., CHEN J., Deng H., Che C.M., Xu A., Vanhoutte P.M.G.R. and Wang Y., Calorie Restriction Prevents Metabolic Aging Caused by Abnormal SIRT1 Function in Adipose Tissues, Diabetes. 2015, 64: 1576-1590.

Researcher : HE Y

List of Research Outputs

Chan E.W., LAU C.Y., Leung W.K., Mok M.T.C., HE Y., Tong T.S.M. and Wong I.C.K., Effectiveness of Gastroprotective Agents on Prevention of Dabigatran Related Gastrointestinal Bleeding: A Population-Based Restrospective Cohort Study, ISOP 2014, Tianjin, China, 19-22 October (oral). 2014.

Chan E.W., LAU C.Y., Leung W.K., Mok T.C., HE Y., Tong S.M. and Wong I.C.K., Effectiveness of gastroprotective agents on prevention of dabigatran related gastrointestinal bleeding: a population-based retrospective cobort study, 14th ISoP Annual Meeting "New Ideas in Ancient Cultures: Advancing Pharmacovigilance in Asia", 19-22 October 2014, Tianjin China. 2014.

Chan E.W., Lau C.Y., Leung W.K., Mok M.T.C., He Y., Tong S.M. and Wong I.C.K., Prevention of Dabigatran-related Gastrointestinal Bleeding With Gastroprotective Agents: A Population-Based Study, Gastroenterology. 2015.

HE Y., Chan E.W., Man K.C.K., LAU C.Y., Leung W.K., Ho L.M. and Wong I.C.K., Dosage Effects of Histamine-2 Receptor Antagonist on the Primary Prophylaxis of Non-Steroidal Anti-Inflammatory Drug (NSAID)-Associated Peptic Ulcers: A Retrospective Cohort Study, Drug Safety. 2014, 37: 711-721.

HE Y., WONG Y.S., Chan E.W., LAU C.Y., Man K.C.K., CHUI S.L.C., Worsley A.J. and Wong I.C.K., Safety of tofacitinib in the treatment of rheumatoid arthritis: a systematic review and meta-analysis, International Society of Pharmacovigilance XIII meeting, Pisa, October 1-4, International Society for Pharmacoepidemiology (ISPE) 8th Asian Conference on Pharmacoepidemiology; The University of Hong Kong, 25-27 October. 2014.

He Y., Chan E.W., Leung W.K., Anand S. and Wong I.C.K., Systematic review with meta-analysis: the association between the use of calcium channel blockers and gastrointestinal bleeding, Alimentary Pharmacology & Therapeutics. 2015, 41: 1246-1255.

LAU C.Y., Chan E.W., Wong I.C.K., HE Y., Tong S.M. and Leung W.K., Use of gastroprotective agents and risk of dabigatran associated gastrointestinal bleeding: a population-based retrospective cohort study, United European Gastroenterology (UEG) Week,18-22 October, Vienna. 2014.

Zhang L., Wong L.Y.L., HE Y. and Wong I.C.K., Pharmacovigilance in China: Current Situation, Successes and Challenges, Drug Saf.. 2014.

Researcher : He Y

List of Research Outputs

Zhang L., Wong L.Y.L., HE Y. and Wong I.C.K., Pharmacovigilance in China: Current Situation, Successes and Challenges, Drug Saf.. 2014.

Researcher : Hsia Y

List of Research Outputs

Hsu W.W.Q., Chan E.W., Zhang Z., Lin Z.X., Bian Z.X., Hsia Y. and Wong I.C.K., A survey to investigate attitudes and perceptions of Chinese medicine professionals in health information technology in Hong Kong, Eur J Integr Med. 2015, 7(1): 36-46.

Man K.C.K., Ip P., Hsia Y., Chan E.W., Chui S.L.C., Lam M.P.S., Wong W.H.S., Chow C.B., Yung A.W.Y. and Wong I.C.K., ADHD Drug Prescribing Trend Is Increasing Among Children and Adolescents in Hong Kong, Journal of Attention Disorders published online 3 July 2014. 2014.

Researcher : Huang B

List of Research Outputs

Deng H., Huang B., Xu C., Park S., Xu A., Lee I.K. and Wang Y., Reduced Clusterin Contents Contribute to The Pro-Inflammatory and Pro-Senescent Activity of Low Density Lipoprotein Particles in Adiponectin Deficient Mice, The 9th Congress of the Asian-Pacific Society of Atherosclerosis and Vascular Disease and 16th Diabetes and Cardiovascular Risk Factor – East Meets West Symposium. Japan, Japan Atherosclerosis Society, 2014, 21: S34.

Song E., WANG Y., Huang B. and Wang Y., Gas chromatograph and mass spectrum (GC/MS) study about polyamination /deamidation of lipocalin-2 mutations, 7th Conference of Lipocalin-2 as a Therapeutic Target in Cardio-Metabolic Diseases between HKU team and IdRS Cardiovascular Unit, Servier Laboratories, 2014, December, 2014, Hong Kong. 2014.

Song E., Fan P., Huang B., Deng H., Feletou M., Vilaine J.P., Villeneuve N., Xu A., Vanhoutte P.M.G.R. and Wang Y., Linoleic Acid induced Activation of Lipocalin-2 Causes Endothelial Dysfunction and Hypertension in Obese Mice, U21 Graduate Research Conference 2014 Celebrating Ageing Research, University of Auckland, New Zealand, July 1-4, 2014.

Researcher : KONG WCB

List of Research Outputs

KONG W.C.B., Man R.Y.K., Gao Y.S., Vanhoutte P.M.G.R. and Leung S.W.S., Reduced activity of SK C a and Na-K ATPase underlies the accelerated impairment of EDH-type relaxations in mesenteric arteries of aging spontaneously hypertensive rats , Pharmacology Research & Perspectives. 2015, 3: 1-11.

KONG W.C.B., Vanhoutte P.M.G.R., Man R.Y.K. and Leung S.W.S., 17β-estradiol potentiates endothelium-dependent nitric oxide- and hyperpolarization-mediated relaxations in blood vessels of male but not female apolipoprotein-E deficient mice, Vascular Pharmacology. 2015.

Researcher : Kwok PCL

Project Title:	Inhalable dry powder aerosols for influenza prevention or treatment
Investigator(s):	Kwok PCL, Yen H, Peiris JSM
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012

Project Title:	Inhalable oleanolic acid dry powder for lung diseases
Investigator(s):	Kwok PCL
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2013

Project Title:	Inhalable macromolecule dry powder for asthma treatment in children
Investigator(s):	Kwok PCL, Lam JKW
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Health and Medical Research Fund - Mini Grant
Start Date:	01/2014

Project Title:	Inhalable antimicrobial peptide dry powder for tuberculosis treatment
Investigator(s):	Kwok PCL, Lam JKW
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Small Project Funding
Start Date:	04/2014

Project Title:	17th International Pharmaceutical Technology Symposium (IPTS 2014); Drug nanoparticles: Production, dissolution, and pulmonary drug delivery
Investigator(s):	Kwok PCL
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2014
Completion Date:	09/2014

Project Title:	Aerosol performance of generic pharmaceutical combination inhalers
Investigator(s):	Kwok PCL
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Small Project Funding
Start Date:	04/2015

Project Title:	Dexmedetomidine buccal spray solution for premedication in children
Investigator(s):	Kwok PCL, Dufay S, Yuen VMY
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Health and Medical Research Fund - Mini Grant
Start Date:	05/2015

List of Research Outputs

CHEN S., Mak J.C.W., Tong H.H.Y. and Kwok P.C.L., Inhalable Oleanolic Acid-Hypromellose Particles for Controlled Release, 40th Micro and Nano Engineering 2014, Lausanne, Switzerland, September 22-26, 2014.

Kwok P.C.L. and Chan H.K., Drug nanoparticles: Production, dissolution, and pulmonary drug delivery, 17th International Pharmaceutical Technology Symposium, Antalya, Turkey, 8 – 10 September 2014. 2014, 95.

Kwok P.C.L., Pharmaceutical aerosol electrostatics: A field with much potential for development, Therapeutic Delivery. 2015, 6: 105-107.

LIANG W., CHOW Y.T., Lau P.N., Zhou Q.T., Kwok P.C.L., Leung G.P.H., Mason A.J.M., Chan H.K., Poon L.L.M. and Lam J.K.W., Inhalable powder formulations of siRNA and pH responsive peptides with antiviral activity against H1N1 influenza virus, Molecular Pharmaceutics. 2015, 12: 910-921.

MAN K.W.D., Kwok P.C.L. and Lam J.K.W., Oleanolic Acid Delivery using Biodegradable Nanoparticies for Cancer Therapy, UK Colloids 2014: An International Colloid and Interface Science Symposium, July 6-9, 2014, London, UK. 2014.

MAN K.W.D., Kwok P.C.L. and Lam J.K.W., Oleanolic acid delivery using biodegradable nanoparticles for cancer therapy, UK Colloids 2014 - International Colloid and Interface Science Symposium. 2014.

Man K.W.D., Casettari L., Cepsi C., Bonacucina G., Palmieri F., Sze C.W.S., Leung G.P.H., Lam J.K.W. and Kwok P.C.L., Oleanolic acid loaded PEGylated PLA and PLGA nanoparticles with enhanced cytotoxic activity against cancer cells, Molecular Pharmaceutics. 2015, 12: 2112-2125.

WONG K.L., Wong R.N., ZHANG L., Liu W.K., Ng T.B., Shaw P.C., Kwok P.C.L., Lai Y.M., Zhang Z., Zhang Y., Tong Y., CHEUNG H.P., LU J. and Sze C.W., Bioactive proteins and peptides isolated from Chinese medicines with pharmaceutical potential., Chinese medicine. 2014, 9: 19.

Wong J., Kwok P.C.L., Noakes T., Fathi A., Dehghani F. and Chan H.K., Effect of crystallinity on electrostatic charging in dry powder inhaler formulations, Pharmaceutical Research. Springer US, 2014, 31: 1656-1664.

Researcher : LAN Y

List of Research Outputs

LAN Y., Lam J.T., Siu G.K.H., Yam W.C., Mason A.J. and Lam J.K.W., Cationic amphipathic D-enantiomeric antimicrobial peptides with in vitro and ex vivo activity against drug-resistant Mycobacterium tuberculosis, Tuberculosis. 2014, 94: 678-689.

LAN Y., Mason A.J. and Lam J.K.W., D-enantiomeric antimicrobial peptides as antibacterial agent against drug-resistant Mycobacterium tuberculosis, 17th World Congress of Basic & Clinical Pharmacology. 2014.

Researcher : LAU CY

List of Research Outputs

CHUI S.L.C., Man K.C.K., Cheng C.L., LAU C.Y., Cheng V.C.C., Wong D.S.H., Yan-Kao Y.H. and Wong I.C.K., An investigation of the association between retinal detachment and oral fluoroquinolones: a self-controlled case series study. , International Society of Pharmacovigilance XIII meeting, Pisa, October 1-4 International Society for Pharmacoepidemiology (ISPE) 8th Asian Conference on Pharmacoepidemiology; The University of Hong Kong, 25-27 October. 2014.

Chan E.W., LAU C.Y., Leung W.K., Mok M.T.C., HE Y., Tong T.S.M. and Wong I.C.K., Effectiveness of Gastroprotective Agents on Prevention of Dabigatran Related Gastrointestinal Bleeding: A Population-Based Restrospective Cohort Study, ISOP 2014, Tianjin, China, 19-22 October (oral). 2014.

Chan E.W., LAU C.Y., Leung W.K., Mok T.C., HE Y., Tong S.M. and Wong I.C.K., Effectiveness of gastroprotective agents on prevention of dabigatran related gastrointestinal bleeding: a population-based retrospective cobort study, 14th ISoP Annual Meeting "New Ideas in Ancient Cultures: Advancing Pharmacovigilance in Asia", 19-22 October 2014, Tianjin China. 2014.

Chan E.W., Lau C.Y., Leung W.K., Mok M.T.C., He Y., Tong S.M. and Wong I.C.K., Prevention of Dabigatran-related Gastrointestinal Bleeding With Gastroprotective Agents: A Population-Based Study, Gastroenterology. 2015.

HE Y., Chan E.W., Man K.C.K., LAU C.Y., Leung W.K., Ho L.M. and Wong I.C.K., Dosage Effects of Histamine-2 Receptor Antagonist on the Primary Prophylaxis of Non-Steroidal Anti-Inflammatory Drug (NSAID)-Associated Peptic Ulcers: A Retrospective Cohort Study, Drug Safety. 2014, 37: 711-721.

HE Y., WONG Y.S., Chan E.W., LAU C.Y., Man K.C.K., CHUI S.L.C., Worsley A.J. and Wong I.C.K., Safety of tofacitinib in the treatment of rheumatoid arthritis: a systematic review and meta-analysis, International Society of Pharmacovigilance XIII meeting, Pisa, October 1-4, International Society for Pharmacoepidemiology (ISPE) 8th Asian Conference on Pharmacoepidemiology; The University of Hong Kong, 25-27 October. 2014.

LAU C.Y., ISoP 2014 Junior Prize for best presentation in the 14th Annual Meeting of the International Society of Pharmacovigilance in Tianjin, October 22, 2014., 2014.

LAU C.Y., Chan E.W., Liu K. and Wong I.C.K., The Unmet Needs of Antithrombotic Treatment in Patients with Non-Valvular Atrial Fibrillation in Real-World Clinical Practice, ISOP 2014, Tianjin, China, 19-22 October (oral). 2014.

LAU C.Y., Chan E.W., Wong I.C.K., HE Y., Tong S.M. and Leung W.K., Use of gastroprotective agents and risk of dabigatran associated gastrointestinal bleeding: a population-based retrospective cohort study, United European Gastroenterology (UEG) Week,18-22 October, Vienna. 2014.

Researcher : LI A

List of Research Outputs

LI A., LC-MS/MS method development for dexmedetomidine in human plasma, 19th Research Postgraduate Symposium, December 11, 2014, Hong Kong. 2014.

Researcher : LI J

List of Research Outputs

BAI B., MAN W.C., Liang Y., Deng H., LI J., Wang Y. and Vanhoutte P.M.G.R., Molecular dissection of the interplay between SIRT1, LKB1 and HERC2: linkage implication in endothelial senescence and vascular remodeling, 11th International Symposium on Resistance Arteries, September 7-11, 2014, Banff, Canada. 2014.

Bai B., MAN W.C., LIANG Y., Deng H., LI J., Vanhoutte P.M.G.R. and Wang Y., Molecular dissection of the interplay between SIRT1, LKB1 and HERC2: linkage implication in endothelial senescence and vascular remodeling , The 11th International Symposium on Resistance Arteries. SWITZERLAND, KARGER, 2014, 51(S2).

Researcher : LIANG W

List of Research Outputs

LIANG W., CHOW Y.T., Lau P.N., Zhou Q.T., Kwok P.C.L., Leung G.P.H., Mason A.J.M., Chan H.K., Poon L.L.M. and Lam J.K.W., Inhalable powder formulations of siRNA and pH responsive peptides with antiviral activity against H1N1 influenza virus, Molecular Pharmaceutics. 2015, 12: 910-921.

Researcher : LIANG Y

List of Research Outputs

BAI B., MAN W.C., Liang Y., Deng H., LI J., Wang Y. and Vanhoutte P.M.G.R., Molecular dissection of the interplay between SIRT1, LKB1 and HERC2: linkage implication in endothelial senescence and vascular remodeling, 11th International Symposium on Resistance Arteries, September 7-11, 2014, Banff, Canada. 2014.

Bai B., MAN W.C., LIANG Y., Deng H., LI J., Vanhoutte P.M.G.R. and Wang Y., Molecular dissection of the interplay between SIRT1, LKB1 and HERC2: linkage implication in endothelial senescence and vascular remodeling , The 11th International Symposium on Resistance Arteries. SWITZERLAND, KARGER, 2014, 51(S2).

Researcher : Lam JKW

Project Title:	The use of N-acetyl cysteine grafted chitosan as mucosal adjuvant in intranasal formulation of DNA vaccine
Investigator(s):	Lam JKW
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Small Project Funding
Start Date:	04/2013

Project Title:	King's/HKU Fellowship Awards 2013-14
Investigator(s):	Lam JKW
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	King's/HKU Fellowship Awards
Start Date:	09/2013
Completion Date:	08/2014

Project Title:	Intravaginal delivery of antiretroviral drug using polymeric micelle gel formulation to prevent HIV infection
Investigator(s):	Lam JKW
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Small Project Funding
Start Date:	04/2014

Project Title:	Intranasal Delivery of DNA Vaccine using Oligochitosan/PLGA Nanoparticles
Investigator(s):	Lam JKW
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014

Project Title:	Dry powder formulation of lorazepam for intranasal delivery (for the treatment of emergency seizures)
Investigator(s):	Lam JKW, Wong ICK, Kwok PCL
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2014
Completion Date:	06/2015

Project Title:	17th World Congress of Basic & Clinical Pharmacology 2014; D-enantiomeric antimicrobial peptides as antibacterial agent against drug-resistant Mycobacterium tuberculosis
Investigator(s):	Lam JKW
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2014
Completion Date:	07/2014

Project Title:	Development of a highly effective, pH responsive peptide, siRNA delivery system to the respiratory tract to combat influenza virus infections
Investigator(s):	Lam JKW, Poon LLM
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Formulation of carrier-free inhalable siRNA powders for the treatment of respiratory diseases
Investigator(s):	Lam JKW
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Small Project Funding
Start Date:	04/2015

List of Research Outputs

LAN Y., Lam J.T., Siu G.K.H., Yam W.C., Mason A.J. and Lam J.K.W., Cationic amphipathic D-enantiomeric antimicrobial peptides with in vitro and ex vivo activity against drug-resistant Mycobacterium tuberculosis, Tuberculosis. 2014, 94: 678-689.

LAN Y., Mason A.J. and Lam J.K.W., D-enantiomeric antimicrobial peptides as antibacterial agent against drug-resistant Mycobacterium tuberculosis, 17th World Congress of Basic & Clinical Pharmacology. 2014.

LIANG W., CHOW Y.T., Lau P.N., Zhou Q.T., Kwok P.C.L., Leung G.P.H., Mason A.J.M., Chan H.K., Poon L.L.M. and Lam J.K.W., Inhalable powder formulations of siRNA and pH responsive peptides with antiviral activity against H1N1 influenza virus, Molecular Pharmaceutics. 2015, 12: 910-921.

Lam J.K.W., Formulation of inhalable siRNA therapeutics against respiratory infections, Area of Excellence, Control of Pandemic and Inter-Pandemic Influenza and Control of Influenza Research Joint Seminar. 2015.

Lam J.K.W. and Worsley A.J., What is the future of siRNA therapeutics?, Journal of Drug Design and Research. 2014, 1: 1005.

Lam J.K.W. and Zhang Y., invited lecture to HKU, In: Jenny K.W. LAM, Sze CW, Zhang YB. , modern development and trade of Chinese medicines-I. Dr. Jenny K.W. LAM, Pharmaceutical & Phamacy, LKS Faculty of Medicine, 2015.01.. 2015.

MAN K.W.D., Kwok P.C.L. and Lam J.K.W., Oleanolic Acid Delivery using Biodegradable Nanoparticies for Cancer Therapy, UK Colloids 2014: An International Colloid and Interface Science Symposium, July 6-9, 2014, London, UK. 2014.

MAN K.W.D., Kwok P.C.L. and Lam J.K.W., Oleanolic acid delivery using biodegradable nanoparticles for cancer therapy, UK Colloids 2014 - International Colloid and Interface Science Symposium. 2014.

Man K.W.D., Casettari L., Cepsi C., Bonacucina G., Palmieri F., Sze C.W.S., Leung G.P.H., Lam J.K.W. and Kwok P.C.L., Oleanolic acid loaded PEGylated PLA and PLGA nanoparticles with enhanced cytotoxic activity against cancer cells, Molecular Pharmaceutics. 2015, 12: 2112-2125.

Perinelli D.R., Casettari L., Cespi M., Fini F., Man K.W.D., Giorgioni G., Canala S., Lam J.K.W., Bonacucina G. and Palmieri G.F., Toxicological profiles and surface properties at physiological pH of N-decanoyl amino acids, AAPS Italian University Network, 9th Annual Meeting, From Food to pharma: the polyhydral nature of polymers. 2015.

XU Y., Yuen P.W. and Lam J.K.W., Intranasal DNA vaccine for protection against respiratory infectious diseases: the delivery perspectives, Pharmaceutics. MDPI, 2014, 6 (3): 378-415.

Researcher : Lam MPS

List of Research Outputs

Lam M.P.S., Plenary Session: Pharmacy Council, Hong Kong Pharmacy Conference 2015, 28-29 Mar, 2015, Hong Kong. 2015.

Lam M.P.S., Undergraduate program of clinical pharmacy at University of Hong Kong, 2015 China International Symposium on Clinical Pharmacy Education, 25 May, 2015, Nanjing. 2015.

Man K.C.K., Ip P., Hsia Y., Chan E.W., Chui S.L.C., Lam M.P.S., Wong W.H.S., Chow C.B., Yung A.W.Y. and Wong I.C.K., ADHD Drug Prescribing Trend Is Increasing Among Children and Adolescents in Hong Kong, Journal of Attention Disorders published online 3 July 2014. 2014.

Researcher : Lau CY

List of Research Outputs

LAU C.Y., ISoP 2014 Junior Prize for best presentation in the 14th Annual Meeting of the International Society of Pharmacovigilance in Tianjin, October 22, 2014., 2014.

Researcher : Leung GPH

Project Title:	Cloning and characterization of novel equilibrative nucleoside transporter type 4 (ENT4)
Investigator(s):	Leung GPH
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2005

Project Title:	Vascular protective effect of ADTM
Investigator(s):	Leung GPH
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013

Project Title:	Vascular protective effect of narirutin
Investigator(s):	Leung GPH
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Small Project Funding
Start Date:	06/2014

Project Title:	Effects of novel Rho kinase inhibitors on human nucleoside transporters
Investigator(s):	Leung GPH
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2015

List of Research Outputs

CAI Y., MANIO M.M., Leung G.P.H., Xu A., Tang E.H.C. and Vanhoutte P.M.G.R., Thyroid hormone affects both endothelial and vascular smooth muscle cells in rat arteries, European Journal of Pharmacology. 2015, 747: 18-28.

CHEUNG C., Cheung K.H. and Leung G.P.H., Mechanisms of action of Xinmailong, a Chinese Medicine derived from Periplaneta Americana, in treating heart failure, 17th World Congress of Basic and Clinical Pharmacology 2014, Cape Town, South Africa from 13-18 July 2014.

Chen H., Li S., Wang P., Yan S., Hu L., Pan X., Yang C. and Leung G.P.H., Endothelium-dependent and -independent relaxation of rat aorta induced by extract of Schizophyllum commune, Phytomedicine. 2014, 21: 1230-1236.

Cui G.Z., Luk C.W.S., Li R.A., Chan K.K.K., Lei S.W., Wang L., Shen H.F., Leung G.P.H. and Lee S.M.Y., Cytoprotection of Baicalein Against Oxidative Stress-induced Cardiomyocytes Injury Through the Nrf2/Keap1 Pathway, Journal of Cardiovascular Pharmacology. 2015, 65: 39-46.

LIANG W., CHOW Y.T., Lau P.N., Zhou Q.T., Kwok P.C.L., Leung G.P.H., Mason A.J.M., Chan H.K., Poon L.L.M. and Lam J.K.W., Inhalable powder formulations of siRNA and pH responsive peptides with antiviral activity against H1N1 influenza virus, Molecular Pharmaceutics. 2015, 12: 910-921.

Leung G.P.H., Equilibrative nucleoside transporter 1 and 4: which one is a better target for cardioprotection against ischemia-reperfusion injury?, 6th Scientific meeting of the Asian Society for Vascular Biology, Malaysia. 2014.

Leung G.P.H. and Zhang Y., Invited lecture to HKU, In: Leung PH, Zhang YB, western drug development and direction. Dr Leung PH, Pharmaceutical & Phamacy, LKS Faculty of Medicine, 2014.10. . 2014.

Li S., Zhou X.L., Dang Y.Y., Kwan Y.W., Chan S.W., Leung G.P.H., Lee S.M.Y. and Hoi M.P.M., Basal Flt1 tyrosine kinase activity is a positive regulator of endothelial survival and vascularization during zebrafish embryogenesis, Biochimica et Biophysica Acta (BBA) - General Subjects. 2015, 1850: 373-384.

Li S., Dang Y.Y., Che O.L.G., Kwan Y.W., Chan S.W., Leung G.P.H., Lee S.M.Y. and Hoi M.P.M., VEGFR tyrosine kinase inhibitor II (VRI) induced vascular insufficiency in zebrafish as a model for studying vascular toxicity and vascular preservation, Toxicology and Applied Pharmacology. 2014, 280: 408-420.

Li W.S.R., Yang C., Chan S.W., Hoi M.P.M., Lee S.M.Y., Kwan Y.W. and Leung G.P.H., Relaxation effect of abacavir on rat basilar arteries, PLoS One. 2015, 10(4): e0123043.

Li W.S.R., Yang C., SIT S.M., Kwan Y.W., Lee S.M.Y., Hoi M.P.M., Chan S.W., Hausman M., Vanhoutte P.M.G.R. and Leung G.P.H., Uptake and Protective effects of Ergothioneine in Human Endothelial Cells, J Pharmacol Exp Ther. 2014, 350(3): 691-700.

Man K.W.D., Casettari L., Cepsi C., Bonacucina G., Palmieri F., Sze C.W.S., Leung G.P.H., Lam J.K.W. and Kwok P.C.L., Oleanolic acid loaded PEGylated PLA and PLGA nanoparticles with enhanced cytotoxic activity against cancer cells, Molecular Pharmaceutics. 2015, 12: 2112-2125.

Xu Y.C., Leung S.W.S., Leung G.P.H. and Man R.Y.K., Kaempferol enhances endothelium-dependent relaxation in the porcine coronary artery through activation of large-conductance Ca 2+ -activated K + channels , British Journal of Pharmacology. 2015, 172: 3003-3014.

Yang C. and Leung G.P.H., Equilibrative Nucleoside Transporters 1 and 4, Journal of Cardiovascular Pharmacology. 2015, 65: 517-521.

Researcher : Leung SWS

Project Title:	Effects of non-nucleoside and nucleoside reverse transcriptase inhibitors on vascular inflammation
Investigator(s):	Leung SWS, Vanhoutte PMGR
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013
Completion Date:	11/2014

Project Title:	Therapeutic potential of herbal flavonoids in the management of chronic obstructive pulmonary disease
Investigator(s):	Leung SWS, Mak JCW, Man RYK
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	11/2013

Project Title:	Regulation of endothelium-derived contracting factor release by nitric oxide
Investigator(s):	Leung SWS, Man RYK
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Small Project Funding
Start Date:	06/2014

Project Title:	17th World Congress of Basic and Clinical Pharmacology; Effect of L-citrulline on nitrate tolerance: role of arginase
Investigator(s):	Leung SWS
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2014
Completion Date:	07/2014

Project Title:	Vasoconstrictor signals in hypoxia: role of soluble guanylyl cyclase
Investigator(s):	Leung SWS, Vanhoutte PMGR
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Effect s of different components of the Chinese medicine, Astragali Radix (Huangqi), on angiogenic and inflammatory responses of endothelial cells to atherogenic lipoproteins
Investigator(s):	Leung SWS
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Small Project Funding
Start Date:	06/2015

List of Research Outputs

CHEN H., Leung S.W.S. and Man R.Y.K., Effect of Wy14643 and fenofibrate on acetylcholine-induced contractions in aortic rings from spontaneously hypertensive rats, Eighteenth Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine “Bridging Translational Gap”, 1 Nov 2014, Hong Kong. 2014.

CHEN H., Leung S.W.S. and Man R.Y.K., Wy14643 and fenofibrate reduce acetylcholine-induced contractions in spontaneously hypertensive rat aortae, American Heart Association's Arteriosclerosis, Thrombosis and Vascular Biology 2015 Scientific Sessions, 7 to 9 May 2015, San Francisco, CA, USA. 2015.

CHEN H., Leung S.W.S. and Man R.Y.K., Wy14643 and fenofibrate reduce contractions to hydrogen peroxide in aortae of spontaneously hypertensive rats, ASCEPT-BPS Joint Scientific Meeting "Tomorrow's medicines: pharmacology, patients and populations”, 19-21 May 2015, Hong Kong. 2015.

Chen Z., Zhang X., Ying L., Dou D., Li Y., Bai Y., Liu J., Feng H., Yu X., Leung S.W.S., Vanhoutte P.M.G.R. and Gao Y., Cyclic IMP-synthesized by sGC as a mediator of hypoxic contraction of coronary arteries, American Journal of Physiology - Heart and Circulatory Physiology . 2014, 307 (3): H328-H336.

Chiu T. and Leung S.W.S., Role of extracellular signal-regulated kinase in the regulation of endothelium-depdnent relaxations in porcine coronary arteries, Eighteenth Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine “Bridging Translational Gap”, 1 Nov 2014, Hong Kong. 2014.

DETREMMERIE C.M.S., Leung S.W.S., Xu A., Gao Y. and Vanhoutte P.M.G.R., Endothelium-, soluble guanylyl cyclase-dependent contractions in isolated arteries, Eighteenth Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine “Bridging Translational Gap”, 1 Nov 2014, Hong Kong. 2014.

DETREMMERIE C.M.S., Leung S.W.S., Xu A., Gao Y. and Vanhoutte P.M.G.R., Endothelium-dependent vasoconstrictor signals requiring activation of soluble guanylyl cyclase in isolated arteries, ASCEPT-BPS Joint Scientific Meeting "Tomorrow's medicines: pharmacology, patients and populations" 2015, 19-21 May 2015, Hong Kong. 2015.

DETREMMERIE C.M.S., Leung S.W.S., Xu A., Alkharfy K., Gao Y. and Vanhoutte P.M.G.R., Thymoquinone as a pharmacological tool to study the endothelium-dependent, soluble guanylyl cyclase-dependent augmentation caused by hypoxia in isolated arteries , 17th World Congress of Basic and Clinical Pharmacology, 13 to 18 July, 2014, Cape Town, South Africa. 2014.

Gao Y., Chen Z., Leung S.W.S. and Vanhoutte P.M.G.R., Hypoxic Vasospasm Mediated by cIMP, Journal of Cardiovascular Pharmacology. 2015, 65: 545-548.

KONG W.C.B., Man R.Y.K., Gao Y.S., Vanhoutte P.M.G.R. and Leung S.W.S., Reduced activity of SK C a and Na-K ATPase underlies the accelerated impairment of EDH-type relaxations in mesenteric arteries of aging spontaneously hypertensive rats , Pharmacology Research & Perspectives. 2015, 3: 1-11.

KONG W.C.B., Vanhoutte P.M.G.R., Man R.Y.K. and Leung S.W.S., 17β-estradiol potentiates endothelium-dependent nitric oxide- and hyperpolarization-mediated relaxations in blood vessels of male but not female apolipoprotein-E deficient mice, Vascular Pharmacology. 2015.

Leung S.W.S., Shum K.P.W., Kaesemeyer W.H., Vanhoutte P.M.G.R. and Man R.Y.K., Effect of L-citrulline on nitrate tolerance: role of arginase, 17th World Congress of Basic and Clinical Pharmacology, 13 to 18 July, 2014, Cape Town, South Africa. 2014.

Leung S.W.S., Cao L., ZHANG P., Man R.Y.K. and Mak J.C.W., Effects of isoflavones on the release of inflammatory mediators by cigarette smoke in airway epithelial cells , ASCEPT-BPS Joint Scientific Meeting "Tomorrow's medicines: pharmacology, patients and populations" 2015, 19-21 May 2015, Hong Kong . 2015.

Tsui P.Y., Cheung C.W., Lee Y., Leung S.W.S. and Ng J.K.F., The effectiveness of low-dose desmopressin in improving hypothermia-induced impairment of primary haemostasis under influence of aspirin - a randomized controlled trial., BMC Anesthesiol. 2015, 15: 80.

Xu Y.C., Leung S.W.S., Leung G.P.H. and Man R.Y.K., Kaempferol enhances endothelium-dependent relaxation in the porcine coronary artery through activation of large-conductance Ca 2+ -activated K + channels , British Journal of Pharmacology. 2015, 172: 3003-3014.

ZHANG L., Leung S.W.S. and Man R.Y.K., Prevention of glyceryl trinitrate tolerance by flavonoids, American Heart Association's Arteriosclerosis, Thrombosis and Vascular Biology 2015 Scientific Sessions, 7 to 9 May 2015, San Francisco, CA, USA. 2015.

ZHANG L., Leung S.W.S. and Man R.Y.K., Prevention of glyceryl trinitrate tolerance by flavonoids, Eighteenth Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine “Bridging Translational Gap”, 1 Nov 2014, Hong Kong. 2014.

ZHAO Y., Flavahan S., Leung S.W.S., Xu A., Vanhoutte P.M.G.R. and Flavahan N.A., Elevated pressure causes endothelial dysfunction in mouse carotid arteries by increasing local angiotensin signaling., Am J Physiol Heart Circ Physiol . 2015, 308: H358-H363.

ZOU Q., Leung S.W.S. and Vanhoutte P.M.G.R., TRP channel opening releases endogenous acetylcholine which contributes to endothelium-dependent relaxations induced by mild hypothermia in SHR but not WKY arteries, Journal of Pharmacology and Experimental Therapeutics. 2015.

Researcher : Li M

List of Research Outputs

CAI Y., Li M. and Wang Y., SIRT1 enhances lipid storage and utillzation in adipose tissues by promoting mitophagy: Role of adiponectin, System Approach to Metabolic Diseases, October 1-3, 2014, Chicago, IL, USA. 2014.

Li M., Fan P. and Wang Y., Integrative Approaches for Lipid Analysis, Pharmacologia. 2015.

Li M., Fan P. and Wang Y., Lipidomics in Health and Diseases - Beyond the Analysis of Lipids, Journal of Glycomics & Lipidomics. 2014.

Researcher : Li WSR

List of Research Outputs

Li W.S.R., Yang C., Chan S.W., Hoi M.P.M., Lee S.M.Y., Kwan Y.W. and Leung G.P.H., Relaxation effect of abacavir on rat basilar arteries, PLoS One. 2015, 10(4): e0123043.

Li W.S.R., Yang C., SIT S.M., Kwan Y.W., Lee S.M.Y., Hoi M.P.M., Chan S.W., Hausman M., Vanhoutte P.M.G.R. and Leung G.P.H., Uptake and Protective effects of Ergothioneine in Human Endothelial Cells, J Pharmacol Exp Ther. 2014, 350(3): 691-700.

Researcher : Li X

List of Research Outputs

Li X. and QIAO Y.L., What’s The Optimal Visual Inspection Screening Intervals For Cervical Cancer Screening in Real Practice of Rural China? A Cost-Utility Modeling Study, ISPOR 17th Annual European Congress (2014). 2014, 17: A643.

Researcher : Liang Y

List of Research Outputs

Researcher : Lui WYV

Project Title:	Systematic Development of Molecular Targets for Nasopharyngeal Carcinoma
Investigator(s):	Lui WYV
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	01/2014

Project Title:	ALK inhibitors for head and neck cancer therapy
Investigator(s):	Lui WYV, Wong ICK
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	07/2014

Project Title:	MAPK1 Genomic Alterations as Predictor of Treatment Response and Driver for Tumor Growth in Head and Neck Cancer
Investigator(s):	Lui WYV, Chan YW, Sham PC, Wong TS
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2014

Project Title:	A Precision Therapeutic Tool for Head and Neck Cancer (HNC)
Investigator(s):	Lui WYV
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	03/2015

Project Title:	HKU Overseas Fellowship Awards 2015-16
Investigator(s):	Lui WYV
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	HKU Overseas Fellowship Awards
Start Date:	06/2015

List of Research Outputs

Lui W.Y.V., HKU Overseas Fellowship 2015-16, The University of Hong Kong. 2015.

Lui W.Y.V. and Grandis J.R., US PATENT: Functional Genomics Screening Platform for Head and Neck Cancer (14/604,310), US Patent and Trademark Office, USA. 2015.

Tsang C.M., Cheung K.C., Cheung Y.C., Man K., Lui W.Y.V., Feng Y. and Tsao G.S.W., Berberine suppresses Id-1 expression and inhibits the growth and development of lung metastases in hepatocellular carcinoma, Biochimica et Biophysica Acta. 2014, Epub on 2014-12-08.

Wong I.C.K., Ng Y.K. and Lui W.Y.V., Cancers of the lung, head and neck on the rise: perspectives on the genotoxicity of air Pollution, Chinese Journal of Cancer. 2014, 33(10): 476-480.

Researcher : Luo C

List of Research Outputs

WANG Y., Song E., Luo C. and Wang Y., Role of lipocalin-2 in aldosterone induced cardiac and renal damages, 7th Conference of Lipocalin-2 as a Therapeutic Target in Cardio-Metabolic Diseases between HKU team and IdRS Cardiovascular Unit, Servier Laboratories, 2014, December 2014, Hong Kong,. 2014.

Researcher : MAN KWD

List of Research Outputs

MAN K.W.D., Kwok P.C.L. and Lam J.K.W., Oleanolic Acid Delivery using Biodegradable Nanoparticies for Cancer Therapy, UK Colloids 2014: An International Colloid and Interface Science Symposium, July 6-9, 2014, London, UK. 2014.

MAN K.W.D., Kwok P.C.L. and Lam J.K.W., Oleanolic acid delivery using biodegradable nanoparticles for cancer therapy, UK Colloids 2014 - International Colloid and Interface Science Symposium. 2014.

Man K.W.D., Casettari L., Cepsi C., Bonacucina G., Palmieri F., Sze C.W.S., Leung G.P.H., Lam J.K.W. and Kwok P.C.L., Oleanolic acid loaded PEGylated PLA and PLGA nanoparticles with enhanced cytotoxic activity against cancer cells, Molecular Pharmaceutics. 2015, 12: 2112-2125.

Perinelli D.R., Casettari L., Cespi M., Fini F., Man K.W.D., Giorgioni G., Canala S., Lam J.K.W., Bonacucina G. and Palmieri G.F., Toxicological profiles and surface properties at physiological pH of N-decanoyl amino acids, AAPS Italian University Network, 9th Annual Meeting, From Food to pharma: the polyhydral nature of polymers. 2015.

Researcher : MAN WC

List of Research Outputs

BAI B., MAN W.C., Liang Y., Deng H., LI J., Wang Y. and Vanhoutte P.M.G.R., Molecular dissection of the interplay between SIRT1, LKB1 and HERC2: linkage implication in endothelial senescence and vascular remodeling, 11th International Symposium on Resistance Arteries, September 7-11, 2014, Banff, Canada. 2014.

Bai B., MAN W.C., LIANG Y., Deng H., LI J., Vanhoutte P.M.G.R. and Wang Y., Molecular dissection of the interplay between SIRT1, LKB1 and HERC2: linkage implication in endothelial senescence and vascular remodeling , The 11th International Symposium on Resistance Arteries. SWITZERLAND, KARGER, 2014, 51(S2).

Researcher : MANIO MM

List of Research Outputs

CAI Y., MANIO M.M., Leung G.P.H., Xu A., Tang E.H.C. and Vanhoutte P.M.G.R., Thyroid hormone affects both endothelial and vascular smooth muscle cells in rat arteries, European Journal of Pharmacology. 2015, 747: 18-28.

Researcher : Man KCK

List of Research Outputs

CHUI S.L.C., Man K.C.K., Cheng C.L., LAU C.Y., Cheng V.C.C., Wong D.S.H., Yan-Kao Y.H. and Wong I.C.K., An investigation of the association between retinal detachment and oral fluoroquinolones: a self-controlled case series study. , International Society of Pharmacovigilance XIII meeting, Pisa, October 1-4 International Society for Pharmacoepidemiology (ISPE) 8th Asian Conference on Pharmacoepidemiology; The University of Hong Kong, 25-27 October. 2014.

Cheng C.L., Man K.C.K., Hsia Y., Kao Yang Y.H. and Wong I.C.K., Drug Utilization Pattern in Children with Autism Spectrum Disorder (ASD) in Asian Countries: A Population Based Study, 30th International Conference for Pharmacoepidemiology (ICPE). 2014.

HE Y., Chan E.W., Man K.C.K., LAU C.Y., Leung W.K., Ho L.M. and Wong I.C.K., Dosage Effects of Histamine-2 Receptor Antagonist on the Primary Prophylaxis of Non-Steroidal Anti-Inflammatory Drug (NSAID)-Associated Peptic Ulcers: A Retrospective Cohort Study, Drug Safety. 2014, 37: 711-721.

HE Y., WONG Y.S., Chan E.W., LAU C.Y., Man K.C.K., CHUI S.L.C., Worsley A.J. and Wong I.C.K., Safety of tofacitinib in the treatment of rheumatoid arthritis: a systematic review and meta-analysis, International Society of Pharmacovigilance XIII meeting, Pisa, October 1-4, International Society for Pharmacoepidemiology (ISPE) 8th Asian Conference on Pharmacoepidemiology; The University of Hong Kong, 25-27 October. 2014.

Lai E.C.C., Man K.C.K., Chaiyakunapruk N., Cheng C.L., Chien H.C., CHUI S.L.C., Dilokthornsakul P., Chantelle H.N., Hsieh C.Y. and Hsu C.Y., Databases in the Asia-Pacific Region:The Potential for a Distributed Network Approach, Epidemiology. 2015, 1.

Man K.C.K., Ip P., Hsia Y., Chan E.W., Chui S.L.C., Lam M.P.S., Wong W.H.S., Chow C.B., Yung A.W.Y. and Wong I.C.K., ADHD Drug Prescribing Trend Is Increasing Among Children and Adolescents in Hong Kong, Journal of Attention Disorders published online 3 July 2014. 2014.

Man K.C.K., Chan E.W., Douglas I., Ip P., Wong W.H.S., Coghill D. and Wong I.C.K., Attention-Deficit/Hyperactivity Disorder (ADHD) Pharmacological Treatment and Its Effect on Accident and Emergency Admission Due to Injury: A Self-Controlled Case-Series Study, 30th International Conference for Pharmacoepidemiology (ICPE). 2014.

Man K.C.K., Tong H.Y.H., Wong L.Y.L., Chan E.W., Simonoff E. and Wong I.C.K., Exposure to selective serotonin reuptake inhibitors during pregnancy and risk of autism spectrum disorder in children: A systematic review and meta-analysis of observational studies, Neuroscience & Biobehavioral Reviews. 2014, 49: 82-89.

Man K.C.K., Chan E.W., Coghill D., Douglas I., Ip P., Leung L.P., Tsui M.S.H., Wong W.H.S. and Wong I.C.K., Methylphenidate and the Risk of Trauma, PEDIATRICS. 2014, 135(1): 40-48.

Pratt N., Chan E.W., Choi N.K., Kimura M., Kimura T., Kubota K., Lai E.C.C., Man K.C.K., Ooba N., Park B.J., Sato T., Shin J.Y., Wong I.C.K., Kao Yang Y.H. and Roughead E.E., Prescription sequence symmetry analysis: assessing risk, temporality, and consistency for adverse drug reactions across datasets in five countries, Pharmacoepidemiology and Drug Safety. 2015, 24.

Researcher : Man KWD

List of Research Outputs

Researcher : Man RYK

Project Title:	Peroxisome Proliferator-Activated Receptors and Vascular Function
Investigator(s):	Man RYK, Leung SWS, Vanhoutte PMGR
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2011
Completion Date:	12/2014

Project Title:	Potential protective effects of L-citrulline supplementation against endothelial dysfunction: role of arginase
Investigator(s):	Man RYK, Leung SWS
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Small Project Funding
Start Date:	03/2013
Completion Date:	08/2014

Project Title:	Vascular effects of 8-pCPT, an Epac activator
Investigator(s):	Man RYK, Leung SWS
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Small Project Funding
Start Date:	06/2014
Completion Date:	12/2015

Project Title:	Prevention of the development of nitroglycerin tolerance by flavonoids
Investigator(s):	Man RYK, Leung SWS
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Small Project Funding
Start Date:	06/2015
Completion Date:	06/2015

List of Research Outputs

CHEN H., Leung S.W.S. and Man R.Y.K., Effect of Wy14643 and fenofibrate on acetylcholine-induced contractions in aortic rings from spontaneously hypertensive rats, Eighteenth Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine “Bridging Translational Gap”, 1 Nov 2014, Hong Kong. 2014.

CHEN H., Leung S.W.S. and Man R.Y.K., Wy14643 and fenofibrate reduce acetylcholine-induced contractions in spontaneously hypertensive rat aortae, American Heart Association's Arteriosclerosis, Thrombosis and Vascular Biology 2015 Scientific Sessions, 7 to 9 May 2015, San Francisco, CA, USA. 2015.

CHEN H., Leung S.W.S. and Man R.Y.K., Wy14643 and fenofibrate reduce contractions to hydrogen peroxide in aortae of spontaneously hypertensive rats, ASCEPT-BPS Joint Scientific Meeting "Tomorrow's medicines: pharmacology, patients and populations”, 19-21 May 2015, Hong Kong. 2015.

KONG W.C.B., Man R.Y.K., Gao Y.S., Vanhoutte P.M.G.R. and Leung S.W.S., Reduced activity of SK C a and Na-K ATPase underlies the accelerated impairment of EDH-type relaxations in mesenteric arteries of aging spontaneously hypertensive rats , Pharmacology Research & Perspectives. 2015, 3: 1-11.

KONG W.C.B., Vanhoutte P.M.G.R., Man R.Y.K. and Leung S.W.S., 17β-estradiol potentiates endothelium-dependent nitric oxide- and hyperpolarization-mediated relaxations in blood vessels of male but not female apolipoprotein-E deficient mice, Vascular Pharmacology. 2015.

Leung S.W.S., Shum K.P.W., Kaesemeyer W.H., Vanhoutte P.M.G.R. and Man R.Y.K., Effect of L-citrulline on nitrate tolerance: role of arginase, 17th World Congress of Basic and Clinical Pharmacology, 13 to 18 July, 2014, Cape Town, South Africa. 2014.

Leung S.W.S., Cao L., ZHANG P., Man R.Y.K. and Mak J.C.W., Effects of isoflavones on the release of inflammatory mediators by cigarette smoke in airway epithelial cells , ASCEPT-BPS Joint Scientific Meeting "Tomorrow's medicines: pharmacology, patients and populations" 2015, 19-21 May 2015, Hong Kong . 2015.

Xu Y.C., Leung S.W.S., Leung G.P.H. and Man R.Y.K., Kaempferol enhances endothelium-dependent relaxation in the porcine coronary artery through activation of large-conductance Ca 2+ -activated K + channels , British Journal of Pharmacology. 2015, 172: 3003-3014.

ZHANG L., Leung S.W.S. and Man R.Y.K., Prevention of glyceryl trinitrate tolerance by flavonoids, American Heart Association's Arteriosclerosis, Thrombosis and Vascular Biology 2015 Scientific Sessions, 7 to 9 May 2015, San Francisco, CA, USA. 2015.

ZHANG L., Leung S.W.S. and Man R.Y.K., Prevention of glyceryl trinitrate tolerance by flavonoids, Eighteenth Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine “Bridging Translational Gap”, 1 Nov 2014, Hong Kong. 2014.

Researcher : SING CW

List of Research Outputs

SING C.W. and Cheung C.L., 20th Medical Research Conference, January 17, 2015, Hong Kong, Drug-induced agranulocytosis in Southern Chinese population: a twelve-year retrospective study. 2015.

SING C.W., Cheung C.L., Lam K.S.L. and Cheung B.M.Y., Low lean mass and gait speed in people with both diabetes and peripheral arterial disease, Tenth International Symposium on Healthy Aging, " A Decade of Positive Aging" March 7-8, 2015, Hong Kong. 2015.

SING C.W., Cheung C.L., Wong I.C.K., Cheung B.M.Y., Yeung C.K., Chan H.H.L. and Chan C.Y.J., Toxic Epidermal Necrolysis: Clinical profile, aetiology and treatment in a tertiary hospital over a 16-year period. , Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and the British Pharmacological Society (BPS) Joint Scientific Meeting. 2015.

SING C.W., Cheung C.L., Cheung B.M.Y., Wong I.C.K. and Chan C.Y.J., Toxic epidermal necrolysis: clinical profile in a tertiary hospital over a 15-year period, 19th Research Postgraduate Symposium, December 11, 2014, Hong Kong. 2014.

Researcher : SIT SM

List of Research Outputs

Li W.S.R., Yang C., SIT S.M., Kwan Y.W., Lee S.M.Y., Hoi M.P.M., Chan S.W., Hausman M., Vanhoutte P.M.G.R. and Leung G.P.H., Uptake and Protective effects of Ergothioneine in Human Endothelial Cells, J Pharmacol Exp Ther. 2014, 350(3): 691-700.

Researcher : Song E

List of Research Outputs

Song E., WANG Y., Huang B. and Wang Y., Gas chromatograph and mass spectrum (GC/MS) study about polyamination /deamidation of lipocalin-2 mutations, 7th Conference of Lipocalin-2 as a Therapeutic Target in Cardio-Metabolic Diseases between HKU team and IdRS Cardiovascular Unit, Servier Laboratories, 2014, December, 2014, Hong Kong. 2014.

Song E., Fan P., Huang B., Deng H., Feletou M., Vilaine J.P., Villeneuve N., Xu A., Vanhoutte P.M.G.R. and Wang Y., Linoleic Acid induced Activation of Lipocalin-2 Causes Endothelial Dysfunction and Hypertension in Obese Mice, U21 Graduate Research Conference 2014 Celebrating Ageing Research, University of Auckland, New Zealand, July 1-4, 2014.

WANG Y., Song E., Luo C. and Wang Y., Role of lipocalin-2 in aldosterone induced cardiac and renal damages, 7th Conference of Lipocalin-2 as a Therapeutic Target in Cardio-Metabolic Diseases between HKU team and IdRS Cardiovascular Unit, Servier Laboratories, 2014, December 2014, Hong Kong,. 2014.

Researcher : Tang EHC

Project Title:	Activation of prostaglandin E receptor 4: a novel anti-inflammatory mechanism that protects against adipose tissue inflammation and obesity-related complications.
Investigator(s):	Tang EHC, Vanhoutte PMGR, Xu A
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	08/2012

Project Title:	Telomere-independent Rap1 contributes to inflammation during atherosclerosis
Investigator(s):	Tang EHC, Man RYK, Leung SWS
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2013

Project Title:	Regulation of triglyceride metabolism by prostaglandin E receptor subtype 4
Investigator(s):	Tang EHC
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013

Project Title:	Rap1 aggravates the development of angiotensin II-induced aortic abdominal aneurysm in apolipoprotein E-deficient mice.
Investigator(s):	Tang EHC
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

Project Title:	Enhancement of the fat-burning capacity of white and brown adipose tissue by activation of prostaglandin E receptor subtype 4
Investigator(s):	Tang EHC
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	12/2014

List of Research Outputs

CAI Y., Vanhoutte P.M.G.R. and Tang E.H.C., Repressor activator protein 1 induces pro-inflammatory cytokines production in macrophages through NFKB signaling, Eighteenth Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine. 2014.

CAI Y., MANIO M.M., Leung G.P.H., Xu A., Tang E.H.C. and Vanhoutte P.M.G.R., Thyroid hormone affects both endothelial and vascular smooth muscle cells in rat arteries, European Journal of Pharmacology. 2015, 747: 18-28.

Tang E.H.C., Cai Y., Wong C.K., Rocha V.Z., Sukhova G.K., Shimizu K., GE X., Vanhoutte P.M.G.R., Libby P. and Xu A., Activation of prostaglandin E2-EP4 signaling reduces chemokine production in adipose tissue , Journal of Lipid Research. 2015, 56(2): 358-368.

WONG H.K., Vanhoutte P.M.G.R. and Tang E.H.C., Deletion of repressor activator protein 1 modulates vascular function in mouse aorta, ASCEPT-BPS Joint Scientific Meeting, Tomorrow's medicines: pharmacology, patients and populations, May 19-21, 2014, University of Hong Kong. 2015.

WONG H.K., Cai Y. and Tang E.H.C., Knockdown of repressor activator protein 1 facilitated foam cell formation by augmenting cholesterol uptake, Eighteenth Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine " Bridging the Translational Gap", 1 November 2014, Hong Kong 2014.

WONG H.K., Cai Y. and Tang E.H.C., Repressor activator protein 1 suppresses foam cell formation by reducing acetylated or oxidized low-density lipoprotein cholesterol uptake, The Crossroads of Lipid Metabolism and Diabetes, Keystone Symposia on Molecular and Cellular Biology, April 19-24, 2015.

YING F., Cai Y. and Tang E.H.C., Impaired cold tolerance in EP4 knockout mice is not due to compromised recruitment of UCP1, Eighteen Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine. 2014.

YING F., Cai Y. and Tang E.H.C., Prostaglandin E receptor subtype 4 (EP4) suppress CL316243-induced white adipose tissue remodeling without up-registration of UCP1, The Crossroads of Lipid Metabolism and Diabetes, Keystone Symposia on Molecular and Cellular Biology, April 19-24, 2015, Copenhagen, Denmark. 2015.

Researcher : Tang HC

Project Title:	Activation of prostaglandin E receptor 4: a novel anti-inflammatory mechanism that protects against adipose tissue inflammation and obesity-related complications.
Investigator(s):	Tang EHC, Vanhoutte PMGR, Xu A
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	08/2012

Project Title:	Telomere-independent Rap1 contributes to inflammation during atherosclerosis
Investigator(s):	Tang EHC, Man RYK, Leung SWS
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2013

Project Title:	Regulation of triglyceride metabolism by prostaglandin E receptor subtype 4
Investigator(s):	Tang EHC
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013

Project Title:	Rap1 aggravates the development of angiotensin II-induced aortic abdominal aneurysm in apolipoprotein E-deficient mice.
Investigator(s):	Tang EHC
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

Project Title:	Enhancement of the fat-burning capacity of white and brown adipose tissue by activation of prostaglandin E receptor subtype 4
Investigator(s):	Tang EHC
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	12/2014

List of Research Outputs

Researcher : Tom WM

Project Title:	VII World Conference on Clinical Pharmacology and Therapeutics 4th Congress of the European Association for Clinical Pharmacology and Therapeutics Antidotal Mechanisms of Hydroxyacetone and Dihydroxyacetone in the Treatment of Acute Acetonitrile Poisoning
Investigator(s):	Tom WM
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2000

Researcher : Tong HYH

List of Research Outputs

Man K.C.K., Tong H.Y.H., Wong L.Y.L., Chan E.W., Simonoff E. and Wong I.C.K., Exposure to selective serotonin reuptake inhibitors during pregnancy and risk of autism spectrum disorder in children: A systematic review and meta-analysis of observational studies, Neuroscience & Biobehavioral Reviews. 2014, 49: 82-89.

Researcher : Vanhoutte P.M.G.

Project Title:	Annual Summer School in Danish Cardiovascular Research Academy Veins in health and disease
Investigator(s):	Vanhoutte PMGR
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2007

Project Title:	Visiting Research Professors Scheme 2009-10
Investigator(s):	Vanhoutte PMGR
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Visiting Research Professors Scheme
Start Date:	09/2009

Project Title:	A Study of the Relative Significance of Nitric Oxide Synthase vs NADPH oxidase in Endothelial Senescence
Investigator(s):	Vanhoutte PMGR, Wang Y
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Small Project Funding
Start Date:	10/2009

List of Research Outputs

Researcher : Vanhoutte PMGR

Project Title:	Annual Summer School in Danish Cardiovascular Research Academy Veins in health and disease
Investigator(s):	Vanhoutte PMGR
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2007

Project Title:	Visiting Research Professors Scheme 2009-10
Investigator(s):	Vanhoutte PMGR
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Visiting Research Professors Scheme
Start Date:	09/2009

Project Title:	A Study of the Relative Significance of Nitric Oxide Synthase vs NADPH oxidase in Endothelial Senescence
Investigator(s):	Vanhoutte PMGR, Wang Y
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Small Project Funding
Start Date:	10/2009

List of Research Outputs

BAI B., MAN W.C., Liang Y., Deng H., LI J., Wang Y. and Vanhoutte P.M.G.R., Molecular dissection of the interplay between SIRT1, LKB1 and HERC2: linkage implication in endothelial senescence and vascular remodeling, 11th International Symposium on Resistance Arteries, September 7-11, 2014, Banff, Canada. 2014.

BARETELLA O.M., Xu A. and Vanhoutte P.M.G.R., Interaction between IP, TP, and 5-HT₂ receptors during contractions to prostacyclin in rat renal arteries, ASCEPT-BPS Joint Scientific Meeting, Tomorrow's medicines: pharmacology, patients and populations, May 19-21, 2015, Hong Kong. 2015.

BARETELLA O.M., Xu A. and Vanhoutte P.M.G.R., Prostagiandin 12 Receptor blockade Contracts Rat Renal Arteries and Facilitates Endothelium-Dependent Contractions, High Blood Pressure Research 2014, September 9-12, 2014 San Francisco, CA. 2014.

BARETELLA O.M., Xu A. and Vanhoutte P.M.G.R., Role of IP receptors in renal basal arterial tone and endothelium-dependent contractions, Eighteenth Annual Scientific Meeting, Institute of Cardiovascular Science and Medicine, November 1, 2014, Hong Kong. 2014.

Bai B., MAN W.C., LIANG Y., Deng H., LI J., Vanhoutte P.M.G.R. and Wang Y., Molecular dissection of the interplay between SIRT1, LKB1 and HERC2: linkage implication in endothelial senescence and vascular remodeling , The 11th International Symposium on Resistance Arteries. SWITZERLAND, KARGER, 2014, 51(S2).

Baretella O.M., Xu A. and Vanhoutte P.M.G.R., Increase in vasomotor tone upon IP receptor blockade in isolated murine renal arteries-role of lipoxygenase(s), 17th World Congress of Basic & Clinical Pharmacology, July 13-18, 2014, Cape Town, South Africa. 2014.

CAI Y., Vanhoutte P.M.G.R. and Tang E.H.C., Repressor activator protein 1 induces pro-inflammatory cytokines production in macrophages through NFKB signaling, Eighteenth Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine. 2014.

CAI Y., MANIO M.M., Leung G.P.H., Xu A., Tang E.H.C. and Vanhoutte P.M.G.R., Thyroid hormone affects both endothelial and vascular smooth muscle cells in rat arteries, European Journal of Pharmacology. 2015, 747: 18-28.

Chen Z., Zhang X., Ying L., Dou D., Li Y., Bai Y., Liu J., Feng H., Yu X., Leung S.W.S., Vanhoutte P.M.G.R. and Gao Y., Cyclic IMP-synthesized by sGC as a mediator of hypoxic contraction of coronary arteries, American Journal of Physiology - Heart and Circulatory Physiology . 2014, 307 (3): H328-H336.

DETREMMERIE C.M.S., Leung S.W.S., Xu A., Gao Y. and Vanhoutte P.M.G.R., Endothelium-, soluble guanylyl cyclase-dependent contractions in isolated arteries, Eighteenth Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine “Bridging Translational Gap”, 1 Nov 2014, Hong Kong. 2014.

DETREMMERIE C.M.S., Leung S.W.S., Xu A., Gao Y. and Vanhoutte P.M.G.R., Endothelium-dependent vasoconstrictor signals requiring activation of soluble guanylyl cyclase in isolated arteries, ASCEPT-BPS Joint Scientific Meeting "Tomorrow's medicines: pharmacology, patients and populations" 2015, 19-21 May 2015, Hong Kong. 2015.

DETREMMERIE C.M.S., Leung S.W.S., Xu A., Alkharfy K., Gao Y. and Vanhoutte P.M.G.R., Thymoquinone as a pharmacological tool to study the endothelium-dependent, soluble guanylyl cyclase-dependent augmentation caused by hypoxia in isolated arteries , 17th World Congress of Basic and Clinical Pharmacology, 13 to 18 July, 2014, Cape Town, South Africa. 2014.

Dufay S., Worsley A.J., Monteillier A., Avanzi C., Sy L.K., Ng T.F., Garcia J.M., Lam M.F., Vanhoutte P.M.G.R. and Wong I.C.K., Herbal tea extracts inhibit Cytochrome P450 3A4 in vitro, Journal of Pharmacy and Pharmacology. 2014, 66: 1478-1490.

Emoto N., Masaki T., Goto K., Vanhoutte P.M.G.R. and Yanagisawa M., Endothelin XIII, Life Sciences. 2014, 118: 47-50.

Gao Y., Chen Z., Leung S.W.S. and Vanhoutte P.M.G.R., Hypoxic Vasospasm Mediated by cIMP, Journal of Cardiovascular Pharmacology. 2015, 65: 545-548.

Gao Y.S. and Vanhoutte P.M.G.R., Tissues cIMPly do not lie, Naunyn-Schmiedeberg's Arch Pharmacol. 2014, 387: 901-903.

KONG W.C.B., Man R.Y.K., Gao Y.S., Vanhoutte P.M.G.R. and Leung S.W.S., Reduced activity of SK C a and Na-K ATPase underlies the accelerated impairment of EDH-type relaxations in mesenteric arteries of aging spontaneously hypertensive rats , Pharmacology Research & Perspectives. 2015, 3: 1-11.

KONG W.C.B., Vanhoutte P.M.G.R., Man R.Y.K. and Leung S.W.S., 17β-estradiol potentiates endothelium-dependent nitric oxide- and hyperpolarization-mediated relaxations in blood vessels of male but not female apolipoprotein-E deficient mice, Vascular Pharmacology. 2015.

Leung S.W.S., Shum K.P.W., Kaesemeyer W.H., Vanhoutte P.M.G.R. and Man R.Y.K., Effect of L-citrulline on nitrate tolerance: role of arginase, 17th World Congress of Basic and Clinical Pharmacology, 13 to 18 July, 2014, Cape Town, South Africa. 2014.

Li W.S.R., Yang C., SIT S.M., Kwan Y.W., Lee S.M.Y., Hoi M.P.M., Chan S.W., Hausman M., Vanhoutte P.M.G.R. and Leung G.P.H., Uptake and Protective effects of Ergothioneine in Human Endothelial Cells, J Pharmacol Exp Ther. 2014, 350(3): 691-700.

Osto E., Doytcheva P., Corteville C., Bueter M., Dorig C., Stivala S., Buhmann H., Colin S., Rohrer L., Hasballa R., Tailleux A., Wolfrum C., Tona F., Manz J., Vetter D., Spliethoff K., Vanhoutte P.M.G.R., Landmesser U., Pattou F., Staels B., Matter C.M., Lutz T.A. and Luscher T.F., Rapid and Body Weight-Independent Improvement of Endothelial and High-Density Lipoprotein Function After Roux-en-Y Gastric Bypass: Role of Glucagon-Like Peptide-1, Circulation. 2015, 131: 871-881.

Raffai G., Khang G. and Vanhoutte P.M.G.R., Vanillin and Vanillin Analogs Relax Porcine Coronary and Basilar Arteries by Inhibiting L-Type Ca2+ Channels, Journal of Pharmacology and Experimental Therapeutics. 2014, 352: 14-22.

Song E., Fan P., Huang B., Deng H., Feletou M., Vilaine J.P., Villeneuve N., Xu A., Vanhoutte P.M.G.R. and Wang Y., Linoleic Acid induced Activation of Lipocalin-2 Causes Endothelial Dysfunction and Hypertension in Obese Mice, U21 Graduate Research Conference 2014 Celebrating Ageing Research, University of Auckland, New Zealand, July 1-4, 2014.

Svenningsen P., Andersen K., Thuesen A.D., Shin H.S., Vanhoutte P.M.G.R., Skett O., Jensen B.L., Hill C. and Hansen P.B.L., T-type Ca2+ channels facilitate NO-formation, vasodilatation and NO-mediated modulation of blood pressure, Pflügers Archiv - European Journal of Physiology. 2014, 466: 2205-2214.

Tang E.H.C., Cai Y., Wong C.K., Rocha V.Z., Sukhova G.K., Shimizu K., GE X., Vanhoutte P.M.G.R., Libby P. and Xu A., Activation of prostaglandin E2-EP4 signaling reduces chemokine production in adipose tissue , Journal of Lipid Research. 2015, 56(2): 358-368.

Vanhoutte P.M.G.R., PDE and sGC hand in hand to see the light, Proceedings of the National Academy of Sciences. 2014, 111: 17704-17705.

WONG H.K., Vanhoutte P.M.G.R. and Tang E.H.C., Deletion of repressor activator protein 1 modulates vascular function in mouse aorta, ASCEPT-BPS Joint Scientific Meeting, Tomorrow's medicines: pharmacology, patients and populations, May 19-21, 2014, University of Hong Kong. 2015.

Xu C., CAI Y., Fan P., Bai B., CHEN J., Deng H., Che C.M., Xu A., Vanhoutte P.M.G.R. and Wang Y., Calorie Restriction Prevents Metabolic Aging Caused by Abnormal SIRT1 Function in Adipose Tissues, Diabetes. 2015, 64: 1576-1590.

ZHAO Y., Flavahan S., Leung S.W.S., Xu A., Vanhoutte P.M.G.R. and Flavahan N.A., Elevated pressure causes endothelial dysfunction in mouse carotid arteries by increasing local angiotensin signaling., Am J Physiol Heart Circ Physiol . 2015, 308: H358-H363.

ZOU Q., Leung S.W.S. and Vanhoutte P.M.G.R., TRP channel opening releases endogenous acetylcholine which contributes to endothelium-dependent relaxations induced by mild hypothermia in SHR but not WKY arteries, Journal of Pharmacology and Experimental Therapeutics. 2015.

Researcher : WANG Y

List of Research Outputs

BAI B., MAN W.C., Liang Y., Deng H., LI J., Wang Y. and Vanhoutte P.M.G.R., Molecular dissection of the interplay between SIRT1, LKB1 and HERC2: linkage implication in endothelial senescence and vascular remodeling, 11th International Symposium on Resistance Arteries, September 7-11, 2014, Banff, Canada. 2014.

Bai B., MAN W.C., LIANG Y., Deng H., LI J., Vanhoutte P.M.G.R. and Wang Y., Molecular dissection of the interplay between SIRT1, LKB1 and HERC2: linkage implication in endothelial senescence and vascular remodeling , The 11th International Symposium on Resistance Arteries. SWITZERLAND, KARGER, 2014, 51(S2).

CAI Y., Xu C. and Wang Y., Role of adiponectin in SIRT1-mediated mitochondrial regulation in adipose tissue, The international conference “DNSG 2015: 33rd International Symposium on Diabetes & Nutrition” in Toronto, Canada, June 9-12, 2015.

CAI Y., Li M. and Wang Y., SIRT1 enhances lipid storage and utillzation in adipose tissues by promoting mitophagy: Role of adiponectin, System Approach to Metabolic Diseases, October 1-3, 2014, Chicago, IL, USA. 2014.

Deng H., Huang B., Xu C., Park S., Xu A., Lee I.K. and Wang Y., Reduced Clusterin Contents Contribute to The Pro-Inflammatory and Pro-Senescent Activity of Low Density Lipoprotein Particles in Adiponectin Deficient Mice, The 9th Congress of the Asian-Pacific Society of Atherosclerosis and Vascular Disease and 16th Diabetes and Cardiovascular Risk Factor – East Meets West Symposium. Japan, Japan Atherosclerosis Society, 2014, 21: S34.

Lee C.H.P., Woo Y.C., Wang Y., Yeung C.Y., Xu A. and Lam K.S.L., Obesity, adipokines and cancer: an update, Clinical Endocrinology. 2014, 83(2): 147-156.

Leung T.Y., PARK T.J., Wang Y., Che C.M. and Leung K.M.Y., Isoform-specific responses of metallothioneins in a marine pollution biomonitor, the green-lipped mussel Perna viridis , towards different stress stimulations , PROTEOMICS. 2014, 14: 1796-1807.

Li M., Fan P. and Wang Y., Integrative Approaches for Lipid Analysis, Pharmacologia. 2015.

Li M., Fan P. and Wang Y., Lipidomics in Health and Diseases - Beyond the Analysis of Lipids, Journal of Glycomics & Lipidomics. 2014.

Liang Q., Zhong L., Zhang J., Wang Y., Bornstein S.R., Hong D., Triggle C. and Xu A., FGF21 Maintains Glucose Homeostasis by Mediating the Cross Talk Between Liver and Brain During Prolonged Fasting., Diabetes. 2014, Jul 14 Epub ahead of print.

Lin Z., Pan X., Wu F., Ye D., Zhang Y., Wang Y., Jin L., Lian Q., Huang Y., Ding H., Triggle C., Wang K., Li X. and Xu A., Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice, Circulation. 2015, 131(21): 1861-1871.

Mao L., Lin W., Nie T., Hui X., Gao X., Li K., Ding M., Tang X., Li P. and Wang Y., Absence of Appl2 sensitizes endotoxin shock through activation of PI3K/Akt pathway, Cell & Bioscience. 2014, 4(1): 60.

Song E., WANG Y., Huang B. and Wang Y., Gas chromatograph and mass spectrum (GC/MS) study about polyamination /deamidation of lipocalin-2 mutations, 7th Conference of Lipocalin-2 as a Therapeutic Target in Cardio-Metabolic Diseases between HKU team and IdRS Cardiovascular Unit, Servier Laboratories, 2014, December, 2014, Hong Kong. 2014.

Song E., Fan P., Huang B., Deng H., Feletou M., Vilaine J.P., Villeneuve N., Xu A., Vanhoutte P.M.G.R. and Wang Y., Linoleic Acid induced Activation of Lipocalin-2 Causes Endothelial Dysfunction and Hypertension in Obese Mice, U21 Graduate Research Conference 2014 Celebrating Ageing Research, University of Auckland, New Zealand, July 1-4, 2014.

WANG Y., Song E., Luo C. and Wang Y., Role of lipocalin-2 in aldosterone induced cardiac and renal damages, 7th Conference of Lipocalin-2 as a Therapeutic Target in Cardio-Metabolic Diseases between HKU team and IdRS Cardiovascular Unit, Servier Laboratories, 2014, December 2014, Hong Kong,. 2014.

Wang Y., Molecular Links between Caloric Restriction and Sir2/SIRT1 Activation. , Diabetes & Metabolism Journal . 2014, 38.

Wang Y., National Science and Technology Awards of Advanced Individual, Shenzhen Virtual University Park, The Science Technology and Innovation Committee of Shenzhen Municipality . 2014.

Xu C., CAI Y., Fan P., Bai B., CHEN J., Deng H., Che C.M., Xu A., Vanhoutte P.M.G.R. and Wang Y., Calorie Restriction Prevents Metabolic Aging Caused by Abnormal SIRT1 Function in Adipose Tissues, Diabetes. 2015, 64: 1576-1590.

Ye D., Wang Y., Li H., Jia W., Man K., Lo C.M., Wang Y., Lam K.S.L. and Xu A., Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1α-mediated antioxidant capacity in mice, Hepatology. 2014, 60: 977-989.

Researcher : WONG HK

List of Research Outputs

WONG H.K., Vanhoutte P.M.G.R. and Tang E.H.C., Deletion of repressor activator protein 1 modulates vascular function in mouse aorta, ASCEPT-BPS Joint Scientific Meeting, Tomorrow's medicines: pharmacology, patients and populations, May 19-21, 2014, University of Hong Kong. 2015.

WONG H.K., Cai Y. and Tang E.H.C., Knockdown of repressor activator protein 1 facilitated foam cell formation by augmenting cholesterol uptake, Eighteenth Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine " Bridging the Translational Gap", 1 November 2014, Hong Kong 2014.

WONG H.K., Li Ka Shing Prizes 2012-2013, 2014.

WONG H.K., Cai Y. and Tang E.H.C., Repressor activator protein 1 suppresses foam cell formation by reducing acetylated or oxidized low-density lipoprotein cholesterol uptake, The Crossroads of Lipid Metabolism and Diabetes, Keystone Symposia on Molecular and Cellular Biology, April 19-24, 2015.

Researcher : WONG YS

List of Research Outputs

CHUI S.L.C., Chan E.W., WONG Y.S. and Wong I.C.K., The association between oral fluoroquinolones and incident seizure event, 30th ICPE, Taipei, Taiwan, 24-27 October (poster). 2014.

HE Y., WONG Y.S., Chan E.W., LAU C.Y., Man K.C.K., CHUI S.L.C., Worsley A.J. and Wong I.C.K., Safety of tofacitinib in the treatment of rheumatoid arthritis: a systematic review and meta-analysis, International Society of Pharmacovigilance XIII meeting, Pisa, October 1-4, International Society for Pharmacoepidemiology (ISPE) 8th Asian Conference on Pharmacoepidemiology; The University of Hong Kong, 25-27 October. 2014.

WONG Y.S., Hsia Y.F., Chan E.W., Murphy D.G., Simonoff E., Buitelaar J.K. and Wong I.C.K., The variation of psychopharmacological treatment for people with autistic spectrum disorder (ASD): an international study, International Society for Pharmacoepidemiology (ISPE) 8th Asian Conference on Pharmacoepidemiology; The University of Hong Kong. 2014.

Researcher : Wang Y

Project Title:	Outstanding Young Researcher Award 2009-10
Investigator(s):	Wang Y
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	12/2010

Project Title:	Vascular protective functions of the anti-aging protein SIRT1 by targeting LKB1/AMPK pathway in endothelial cells: tipping the balance towards vascular homeostasis
Investigator(s):	Wang Y, Vanhoutte PMGR
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2011
Completion Date:	08/2014

Project Title:	Role of adipose SIRT1 in regulating systemic energy homeostasis and vascular function: focus on biotin, biotinyl enzymes and lipid metabolism
Investigator(s):	Wang Y, Vanhoutte PMGR
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2012

Project Title:	HERC2 as a regulator of endothelial senescence by modulating SIRT1/LKB1 signaling axis
Investigator(s):	Wang Y, Tse HF
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Activation of lipocalin-2 by deamidation in peri-vascular adipose tissues
Investigator(s):	Wang Y
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

Project Title:	Cell Symposia - Systems Approach to Metabolic Diseases; Calorie restriction prevents adipose SIRT1 dysfunction-induced abnormal chromatin remodeling and metabolic ageing
Investigator(s):	Wang Y
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2014
Completion Date:	10/2014

Project Title:	Molecular dissection of the pathogenic adipose-vascular signaling axis associated with obesity - focusing on polyamination and deamidation of lipocalin-2
Investigator(s):	Wang Y, Yuen KY
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Regulation of T-cell maturation by adiponectin in thymus - role of CD100
Investigator(s):	Wang Y
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2015

List of Research Outputs

Lee C.H.P., Woo Y.C., Wang Y., Yeung C.Y., Xu A. and Lam K.S.L., Obesity, adipokines and cancer: an update, Clinical Endocrinology. 2014, 83(2): 147-156.

Li M., Fan P. and Wang Y., Integrative Approaches for Lipid Analysis, Pharmacologia. 2015.

Li M., Fan P. and Wang Y., Lipidomics in Health and Diseases - Beyond the Analysis of Lipids, Journal of Glycomics & Lipidomics. 2014.

Wang Y., Molecular Links between Caloric Restriction and Sir2/SIRT1 Activation. , Diabetes & Metabolism Journal . 2014, 38.

Wang Y., National Science and Technology Awards of Advanced Individual, Shenzhen Virtual University Park, The Science Technology and Innovation Committee of Shenzhen Municipality . 2014.

Researcher : Wang Y.

Project Title:	Outstanding Young Researcher Award 2009-10
Investigator(s):	Wang Y
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	12/2010

Project Title:	Vascular protective functions of the anti-aging protein SIRT1 by targeting LKB1/AMPK pathway in endothelial cells: tipping the balance towards vascular homeostasis
Investigator(s):	Wang Y, Vanhoutte PMGR
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2011
Completion Date:	08/2014

Project Title:	Role of adipose SIRT1 in regulating systemic energy homeostasis and vascular function: focus on biotin, biotinyl enzymes and lipid metabolism
Investigator(s):	Wang Y, Vanhoutte PMGR
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2012

Project Title:	HERC2 as a regulator of endothelial senescence by modulating SIRT1/LKB1 signaling axis
Investigator(s):	Wang Y, Tse HF
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Activation of lipocalin-2 by deamidation in peri-vascular adipose tissues
Investigator(s):	Wang Y
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

Project Title:	Cell Symposia - Systems Approach to Metabolic Diseases; Calorie restriction prevents adipose SIRT1 dysfunction-induced abnormal chromatin remodeling and metabolic ageing
Investigator(s):	Wang Y
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2014
Completion Date:	10/2014

Project Title:	Molecular dissection of the pathogenic adipose-vascular signaling axis associated with obesity - focusing on polyamination and deamidation of lipocalin-2
Investigator(s):	Wang Y, Yuen KY
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Regulation of T-cell maturation by adiponectin in thymus - role of CD100
Investigator(s):	Wang Y
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2015

List of Research Outputs

Researcher : Wong ICK

Project Title:	Effects of Attention Deficit Hyperactivity Disorder (ADHD) pharmacotherapy on hospital accident and emergency admission due to injury-related events. Acronym: ATHAN (ADHD Treatments and Hospital Accident and emergency admission aNalysis)
Investigator(s):	Wong ICK, Ip P, Wong WHS
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2013
Completion Date:	11/2014

Project Title:	Mother’s preferences and willingness to pay for human papillomavirus vaccination for their daughters: a discrete choice experiment in Hong Kong
Investigator(s):	Wong ICK, McGhee S, Tse VC, Wong CKH, Ip DKM, Chau J
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2014

Project Title:	The association between oral fluoroquinolones and incident seizure event
Investigator(s):	Wong ICK, Chan EW
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Small Project Funding
Start Date:	05/2014

Project Title:	Pharmacology 2014 ; Prevention of Dabigatran Related Gastrointestinal Bleeding With Acid Suppressive Agents. reference 118,/Association between Methylphenidate and Risk of Trauma Related Accident and Emergency Admissions: a self-controlled case-series study” reference 77,/The association between oral fluoroquinolone use and the development of retinal detachment: a systematic review and meta-analysis of observational studies. reference 196
Investigator(s):	Wong ICK
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	12/2014
Completion Date:	12/2014

Project Title:	Pharmacogenomics Assessment of Serious Cutaneous Adverse drug reactions (PASCA): A retrospective study
Investigator(s):	Wong ICK, Cheung CL, Chan CYJ, Sham PC, Cheung BMY
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	Feasibility study of the effects of clonidine and melatonin treatment on sleep architecture of children with ADHD.
Investigator(s):	Wong ICK
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	04/2015

List of Research Outputs

Beckmann J., Hagemann U., Bahri P., Bate A., Boyd I.W., Dal Pan G.J., Edwards B.D., Edwards I.R., Hartigan-Go K., Lindquist M., McEwen J., Moride Y., Olsson S., Pal S.N., Soulaymani-Bencheikh R., Tuccori M., Vaca C.P. and Wong I.C.K., Teaching Pharmacovigilance: the WHO-ISoP Core Elements of a Comprehensive Modular Curriculum, Drug Saf.. 2014.

CHUI S.L.C., Man K.C.K., Cheng C.L., LAU C.Y., Cheng V.C.C., Wong D.S.H., Yan-Kao Y.H. and Wong I.C.K., An investigation of the association between retinal detachment and oral fluoroquinolones: a self-controlled case series study. , International Society of Pharmacovigilance XIII meeting, Pisa, October 1-4 International Society for Pharmacoepidemiology (ISPE) 8th Asian Conference on Pharmacoepidemiology; The University of Hong Kong, 25-27 October. 2014.

CHUI S.L.C., Wong I.C.K., Wong L.Y.L. and Chan E.W., Association between oral fluoroquinolone use and the development of retinal detachment: a systematic review and meta-analysis of observational studies, J Antimicrob Chemother. 2015, 70(4): 971-78.

CHUI S.L.C., Wong I.C.K., Wong L.Y.L. and Chan E.W., The association between oral fluoroquinolone use and the development of retinal detachment: a systematic review and meta-analysis of observational studies, ISOP 2014, Tianjin, China, 19-22 October (poster). 2014.

CHUI S.L.C., Chan E.W., WONG Y.S. and Wong I.C.K., The association between oral fluoroquinolones and incident seizure event, 30th ICPE, Taipei, Taiwan, 24-27 October (poster). 2014.

Chan E.W., LAU C.Y., Leung W.K., Mok M.T.C., HE Y., Tong T.S.M. and Wong I.C.K., Effectiveness of Gastroprotective Agents on Prevention of Dabigatran Related Gastrointestinal Bleeding: A Population-Based Restrospective Cohort Study, ISOP 2014, Tianjin, China, 19-22 October (oral). 2014.

Chan E.W., LAU C.Y., Leung W.K., Mok T.C., HE Y., Tong S.M. and Wong I.C.K., Effectiveness of gastroprotective agents on prevention of dabigatran related gastrointestinal bleeding: a population-based retrospective cobort study, 14th ISoP Annual Meeting "New Ideas in Ancient Cultures: Advancing Pharmacovigilance in Asia", 19-22 October 2014, Tianjin China. 2014.

Chan E.W., Lau C.Y., Leung W.K., Mok M.T.C., He Y., Tong S.M. and Wong I.C.K., Prevention of Dabigatran-related Gastrointestinal Bleeding With Gastroprotective Agents: A Population-Based Study, Gastroenterology. 2015.

Cheng C.L., Man K.C.K., Hsia Y., Kao Yang Y.H. and Wong I.C.K., Drug Utilization Pattern in Children with Autism Spectrum Disorder (ASD) in Asian Countries: A Population Based Study, 30th International Conference for Pharmacoepidemiology (ICPE). 2014.

Cheung C.L., Lam K.S.L., Wong I.C.K. and Cheung B.M.Y., Non-invasive score identifies ultrasonography-diagnosed non-alcoholic fatty liver disease and predicts mortality in the USA, BMC Medicine. 2014, 12: 154.

Cheung K.K.W., Wong I.C.K., Ip P., Chan P.K.L., Lin H.Y.C., Wong L.Y.L. and Chan E.W., Experiences of adolescents and young adults with ADHD in Hong Kong: treatment services and clinical management, BMC Psychiatry. 2015, 15(1): 95.

Djabri A., van't Hoff W., Brock P., Wong I.C.K., Guy R.H. and Delgado-Charro B., Iontophoretic transdermal sampling of iohexol as a non-invasive tool to assess glomerular filtration rate, Pharm Res. 2014.

Dufay S., Worsley A.J., Monteillier A., Avanzi C., Sy L.K., Ng T.F., Garcia J.M., Lam M.F., Vanhoutte P.M.G.R. and Wong I.C.K., Herbal tea extracts inhibit Cytochrome P450 3A4 in vitro, Journal of Pharmacy and Pharmacology. 2014, 66: 1478-1490.

HE Y., Chan E.W., Man K.C.K., LAU C.Y., Leung W.K., Ho L.M. and Wong I.C.K., Dosage Effects of Histamine-2 Receptor Antagonist on the Primary Prophylaxis of Non-Steroidal Anti-Inflammatory Drug (NSAID)-Associated Peptic Ulcers: A Retrospective Cohort Study, Drug Safety. 2014, 37: 711-721.

HE Y., WONG Y.S., Chan E.W., LAU C.Y., Man K.C.K., CHUI S.L.C., Worsley A.J. and Wong I.C.K., Safety of tofacitinib in the treatment of rheumatoid arthritis: a systematic review and meta-analysis, International Society of Pharmacovigilance XIII meeting, Pisa, October 1-4, International Society for Pharmacoepidemiology (ISPE) 8th Asian Conference on Pharmacoepidemiology; The University of Hong Kong, 25-27 October. 2014.

He Y., Chan E.W., Leung W.K., Anand S. and Wong I.C.K., Systematic review with meta-analysis: the association between the use of calcium channel blockers and gastrointestinal bleeding, Alimentary Pharmacology & Therapeutics. 2015, 41: 1246-1255.

Hsu W.W.Q., Chan E.W., Zhang Z., Lin Z.X., Bian Z.X., Hsia Y. and Wong I.C.K., A survey to investigate attitudes and perceptions of Chinese medicine professionals in health information technology in Hong Kong, Eur J Integr Med. 2015, 7(1): 36-46.

Hsu W.W.Q., Chan E.W., Zhang Z., Lin Z.X., Bian Z.X. and Wong I.C.K., Chinese medicine students’ view on electronic prescribing: A survey in Hong Kong, Eur J Integr Med. 2015, 7(1): 47-54.

Kendall J., Maconochie I., Wong I.C.K. and Howard R., A novel multipatient intranasal diamorphine spray for use in acute pain in children: pharmacovigilance data from an observational study, Emerg Med J. . 2014, 0: 1-5.

LAU C.Y., Chan E.W., Liu K. and Wong I.C.K., The Unmet Needs of Antithrombotic Treatment in Patients with Non-Valvular Atrial Fibrillation in Real-World Clinical Practice, ISOP 2014, Tianjin, China, 19-22 October (oral). 2014.

LAU C.Y., Chan E.W., Wong I.C.K., HE Y., Tong S.M. and Leung W.K., Use of gastroprotective agents and risk of dabigatran associated gastrointestinal bleeding: a population-based retrospective cohort study, United European Gastroenterology (UEG) Week,18-22 October, Vienna. 2014.

Liu K.Q.L., Lu H.P., Gong J.R., Wong I.C.K. and Chan E.W., Feasibility of Pharmacist-participated Anticoagulation Management Service (PAMS) in A Regional Hospital in Shanghai: a Pilot Study, ISOP 2014, Tianjin, China, 19-22 October (poster). 2014.

Man K.C.K., Ip P., Hsia Y., Chan E.W., Chui S.L.C., Lam M.P.S., Wong W.H.S., Chow C.B., Yung A.W.Y. and Wong I.C.K., ADHD Drug Prescribing Trend Is Increasing Among Children and Adolescents in Hong Kong, Journal of Attention Disorders published online 3 July 2014. 2014.

Man K.C.K., Chan E.W., Douglas I., Ip P., Wong W.H.S., Coghill D. and Wong I.C.K., Attention-Deficit/Hyperactivity Disorder (ADHD) Pharmacological Treatment and Its Effect on Accident and Emergency Admission Due to Injury: A Self-Controlled Case-Series Study, 30th International Conference for Pharmacoepidemiology (ICPE). 2014.

Man K.C.K., Tong H.Y.H., Wong L.Y.L., Chan E.W., Simonoff E. and Wong I.C.K., Exposure to selective serotonin reuptake inhibitors during pregnancy and risk of autism spectrum disorder in children: A systematic review and meta-analysis of observational studies, Neuroscience & Biobehavioral Reviews. 2014, 49: 82-89.

Man K.C.K., Chan E.W., Coghill D., Douglas I., Ip P., Leung L.P., Tsui M.S.H., Wong W.H.S. and Wong I.C.K., Methylphenidate and the Risk of Trauma, PEDIATRICS. 2014, 135(1): 40-48.

Pratt N., Chan E.W., Choi N.K., Kimura M., Kimura T., Kubota K., Lai E.C.C., Man K.C.K., Ooba N., Park B.J., Sato T., Shin J.Y., Wong I.C.K., Kao Yang Y.H. and Roughead E.E., Prescription sequence symmetry analysis: assessing risk, temporality, and consistency for adverse drug reactions across datasets in five countries, Pharmacoepidemiology and Drug Safety. 2015, 24.

SING C.W., Cheung C.L., Wong I.C.K., Cheung B.M.Y., Yeung C.K., Chan H.H.L. and Chan C.Y.J., Toxic Epidermal Necrolysis: Clinical profile, aetiology and treatment in a tertiary hospital over a 16-year period. , Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and the British Pharmacological Society (BPS) Joint Scientific Meeting. 2015.

SING C.W., Cheung C.L., Cheung B.M.Y., Wong I.C.K. and Chan C.Y.J., Toxic epidermal necrolysis: clinical profile in a tertiary hospital over a 15-year period, 19th Research Postgraduate Symposium, December 11, 2014, Hong Kong. 2014.

WONG Y.S., Hsia Y.F., Chan E.W., Murphy D.G., Simonoff E., Buitelaar J.K. and Wong I.C.K., The variation of psychopharmacological treatment for people with autistic spectrum disorder (ASD): an international study, International Society for Pharmacoepidemiology (ISPE) 8th Asian Conference on Pharmacoepidemiology; The University of Hong Kong. 2014.

Wong I.C.K., Ng Y.K. and Lui W.Y.V., Cancers of the lung, head and neck on the rise: perspectives on the genotoxicity of air Pollution, Chinese Journal of Cancer. 2014, 33(10): 476-480.

Zhang L., Wong L.Y.L., HE Y. and Wong I.C.K., Pharmacovigilance in China: Current Situation, Successes and Challenges, Drug Saf.. 2014.

Researcher : Wong LYL

List of Research Outputs

CHUI S.L.C., Wong I.C.K., Wong L.Y.L. and Chan E.W., Association between oral fluoroquinolone use and the development of retinal detachment: a systematic review and meta-analysis of observational studies, J Antimicrob Chemother. 2015, 70(4): 971-78.

CHUI S.L.C., Wong I.C.K., Wong L.Y.L. and Chan E.W., The association between oral fluoroquinolone use and the development of retinal detachment: a systematic review and meta-analysis of observational studies, ISOP 2014, Tianjin, China, 19-22 October (poster). 2014.

Cheung K.K.W., Wong I.C.K., Ip P., Chan P.K.L., Lin H.Y.C., Wong L.Y.L. and Chan E.W., Experiences of adolescents and young adults with ADHD in Hong Kong: treatment services and clinical management, BMC Psychiatry. 2015, 15(1): 95.

Man K.C.K., Tong H.Y.H., Wong L.Y.L., Chan E.W., Simonoff E. and Wong I.C.K., Exposure to selective serotonin reuptake inhibitors during pregnancy and risk of autism spectrum disorder in children: A systematic review and meta-analysis of observational studies, Neuroscience & Biobehavioral Reviews. 2014, 49: 82-89.

Researcher : Woo WHC

Project Title:	Role of Toll-like Receptor in Obesity-induced Non-Alcohol Fatty Liver Disease
Investigator(s):	Woo WHC, Xu A
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2014

Project Title:	Role of gut microbiota and prebiotics on glucose metabolism during pregnancy
Investigator(s):	Woo WHC
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2015

List of Research Outputs

CHEN J., Xu A. and Woo W.H.C., Regulation of Lipogenesis by Toll like receptor pathway: Effect on Stearyl-CoA Desaturase-1, Tenth International Symposium on Healthy Aging, "A Decade of Positive Aging", March 7-8, 2015, Hong Kong. 2015.

Woo W.H.C., Crosstalk between Toll like receptor signaling and Lipogenesis, Institute of Cardiovascular Science and Medicine/Stem Cell and Regenerative Medicine Consortium . 2014.

Researcher : Worsley AJ

List of Research Outputs

Dufay S., Worsley A.J., Monteillier A., Avanzi C., Sy L.K., Ng T.F., Garcia J.M., Lam M.F., Vanhoutte P.M.G.R. and Wong I.C.K., Herbal tea extracts inhibit Cytochrome P450 3A4 in vitro, Journal of Pharmacy and Pharmacology. 2014, 66: 1478-1490.

HE Y., WONG Y.S., Chan E.W., LAU C.Y., Man K.C.K., CHUI S.L.C., Worsley A.J. and Wong I.C.K., Safety of tofacitinib in the treatment of rheumatoid arthritis: a systematic review and meta-analysis, International Society of Pharmacovigilance XIII meeting, Pisa, October 1-4, International Society for Pharmacoepidemiology (ISPE) 8th Asian Conference on Pharmacoepidemiology; The University of Hong Kong, 25-27 October. 2014.

Lam J.K.W. and Worsley A.J., What is the future of siRNA therapeutics?, Journal of Drug Design and Research. 2014, 1: 1005.

Researcher : XU Y

List of Research Outputs

XU Y., Development of LAH4-l1 peptide as novel DNA vaccine adjuvant, 19th Research Postgraduate Symposium, December 11, 2014, Hong Kong. 2014.

XU Y., Yuen P.W. and Lam J.K.W., Intranasal DNA vaccine for protection against respiratory infectious diseases: the delivery perspectives, Pharmaceutics. MDPI, 2014, 6 (3): 378-415.

Researcher : Xu C

List of Research Outputs

CAI Y., Xu C. and Wang Y., Role of adiponectin in SIRT1-mediated mitochondrial regulation in adipose tissue, The international conference “DNSG 2015: 33rd International Symposium on Diabetes & Nutrition” in Toronto, Canada, June 9-12, 2015.

Deng H., Huang B., Xu C., Park S., Xu A., Lee I.K. and Wang Y., Reduced Clusterin Contents Contribute to The Pro-Inflammatory and Pro-Senescent Activity of Low Density Lipoprotein Particles in Adiponectin Deficient Mice, The 9th Congress of the Asian-Pacific Society of Atherosclerosis and Vascular Disease and 16th Diabetes and Cardiovascular Risk Factor – East Meets West Symposium. Japan, Japan Atherosclerosis Society, 2014, 21: S34.

Xu C., CAI Y., Fan P., Bai B., CHEN J., Deng H., Che C.M., Xu A., Vanhoutte P.M.G.R. and Wang Y., Calorie Restriction Prevents Metabolic Aging Caused by Abnormal SIRT1 Function in Adipose Tissues, Diabetes. 2015, 64: 1576-1590.

Researcher : YING F

List of Research Outputs

YING F., 3rd Prize of an outstanding Poster Presentation at the 18th Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine, November 1, 2014., 2014.

YING F., Cai Y. and Tang E.H.C., Impaired cold tolerance in EP4 knockout mice is not due to compromised recruitment of UCP1, Eighteen Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine. 2014.

YING F., Cai Y. and Tang E.H.C., Prostaglandin E receptor subtype 4 (EP4) suppress CL316243-induced white adipose tissue remodeling without up-registration of UCP1, The Crossroads of Lipid Metabolism and Diabetes, Keystone Symposia on Molecular and Cellular Biology, April 19-24, 2015, Copenhagen, Denmark. 2015.

Researcher : Ye D

Project Title:	Role of lipocalin-2 in nonalcoholic fatty liver disease
Investigator(s):	Ye D, Wang Y
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013
Completion Date:	11/2014

Project Title:	Lipocalin-2 in acute and chronic liver diseases: focusing on neutrophil-mediated innate immune responses
Investigator(s):	Ye D, Wang Y, Wong ICK
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	10/2013

Project Title:	Gut Microbiota Modulation of Host Physiology: The Search for Mechanism (C1); Neutrophil-derived Lipocalin-2 Mediates Nonalcoholic Steatohepatitis through Modulating Crosstalk between Mucosa Immunity and Gut Microbiota
Investigator(s):	Ye D
Department:	Medicine
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2015

Researcher : ZHANG L

List of Research Outputs

ZHANG L., Prevention of glyceryl trinitrate tolerance by flavonoids, 19th Research Postgraduate Symposium, December 11, 2014, Hong Kong. 2014.

ZHANG L., Leung S.W.S. and Man R.Y.K., Prevention of glyceryl trinitrate tolerance by flavonoids, American Heart Association's Arteriosclerosis, Thrombosis and Vascular Biology 2015 Scientific Sessions, 7 to 9 May 2015, San Francisco, CA, USA. 2015.

ZHANG L., Leung S.W.S. and Man R.Y.K., Prevention of glyceryl trinitrate tolerance by flavonoids, Eighteenth Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine “Bridging Translational Gap”, 1 Nov 2014, Hong Kong. 2014.

Researcher : ZHANG P

List of Research Outputs

Leung S.W.S., Cao L., ZHANG P., Man R.Y.K. and Mak J.C.W., Effects of isoflavones on the release of inflammatory mediators by cigarette smoke in airway epithelial cells , ASCEPT-BPS Joint Scientific Meeting "Tomorrow's medicines: pharmacology, patients and populations" 2015, 19-21 May 2015, Hong Kong . 2015.

Researcher : ZHANG Y

List of Research Outputs

ZHANG Y., Anti-inflammatory effect of miR-17-3p on endothelial activation both in vitro and in vivo, 19th Research Postgraduate Symposium, December 10, 2014, Hong Kong. 2014.

Researcher : ZHAO Y

List of Research Outputs

ZHAO Y., Flavahan S., Leung S.W.S., Xu A., Vanhoutte P.M.G.R. and Flavahan N.A., Elevated pressure causes endothelial dysfunction in mouse carotid arteries by increasing local angiotensin signaling., Am J Physiol Heart Circ Physiol . 2015, 308: H358-H363.

Researcher : ZOU Q

List of Research Outputs

ZOU Q., Leung S.W.S. and Vanhoutte P.M.G.R., TRP channel opening releases endogenous acetylcholine which contributes to endothelium-dependent relaxations induced by mild hypothermia in SHR but not WKY arteries, Journal of Pharmacology and Experimental Therapeutics. 2015.

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