DEPT OF MEDICINE



Researcher : Au KW
List of Research Outputs

Liao S., Liu Y., Zhang Y., Au K.W., Lai K.W.H., Siu D.C.W. and Tse H.F., Remodelling of cardiac sympathetic re-innervation with thoracic spinal cord stimulation improves left ventricular function in a porcine model of heart failure., Europace. 2015, 2105 MAR 12: 409.
Yiu K.H., Ng W.S., Chan D., Sit K.Y., Wong A., Lee C.W., Chum H.L., Cheung W.Y., Pun C.T., Ho K.L., CHEN Y., Ho K.M., Kumana C.R., Cheung H.L., Chung M.C., Lau C.P., Au K.W. and Tse H.F., Improved prognosis following renin-angiotensin-aldosterone system blockade in patients undergoing concomitant aortic and mitral valve replacement., Int J Cardiol. 2014. 2014, 177(2): 680-682.


Researcher : Au KY
List of Research Outputs

Chan D.T.M., Au K.Y., MA X., Tse W.W., Chau K.M. and Yung S.S.Y., CD44 expression in serum and kidney correlates with disease activity in lupus nephritis, 52nd European Renal Association/European Dialysis Transplantation Association Congress. 2015.
Chan D.T.M., Au K.Y., MA X., Tse W.W., Chau K.M. and Yung S.S.Y., Serum and renal expression of CD44s and its variants correlate with disease activity in lupus nephritis, World Congress of Nephrology 2015.


Researcher : Bow HYC
List of Research Outputs

Samartzis D., Bow H.Y.C., Karppinen J.I., Luk K.D.K., Cheung B.M.Y. and Cheung K.M.C., Family history of low back pain is a significant predictor of pain and disability between extreme stages of lumbar disc degeneration, 34th Annual Meeting of the Hong Kong Orthopaedic Association. Hong Kong, 2014.
Samartzis D., Bow H.Y.C., Karppinen J.I., Luk K.D.K., Cheung B.M.Y. and Cheung K.M.C., Hypertension is independently associated with lumbar disc degeneration: a large-scale population-based study, 34th Annual Meeting of the Hong Kong Orthopaedic Association. Hong Kong, 2014.
Yim R.L., Lee J.T., Bow H.Y.C., Meij B., Leung V.Y.L., Cheung K.M.C., Vavken P. and Samartzis D., A Systematic Review of the Safety & Efficacy of Mesenchymal Stem Cell for Disc Degeneration: Insights & Future Directions for Regenerative Therapeutics, Stem Cells Dev. 2014.


Researcher : Bu L
Project Title:Investigation of the relationship between ISL1+ and WT1+ heart progenitor cells in humans
Investigator(s):Bu L, Li RA
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


Project Title:Study of cardiomyopathy through genome editing in human pluripotent stem cells
Investigator(s):Bu L, Li RA
Department:Physiology
Source(s) of Funding:Small Project Funding
Start Date:06/2013
Completion Date:12/2014




Researcher : But YKD
List of Research Outputs

Poon R.T.P., Cheung T.T., Kwok P.C., Lee A.S., Li T.W., Loke K.L., Chan S.L., Cheung M.T., Lai T.W., Cheung C.C., Cheung F.Y., Loo C.K., But Y.K.D., Hsu A.S.J., Yu S.C. and Yau T.C.C., Hong Kong consensus recommendations on the management of hepatocellular carcinoma, Liver Cancer. 2015, 4(1): 51-69.


Researcher : CHAN GCW
List of Research Outputs

CHAN G.C.W. and Tang S.C.W., Diabetic Nephropathy: landmark clinical trials and tribulations, Nephrology Dialysis Transplantation [Invited Review; IF 3.577]. 2015, 0: 1-10.
CHAN G.C.W. and Tang S.C.W., Prevalence and Severity of Sleep Apnea in Different Stages of Chronic Kidney Disease, J Am Soc Nephrol. 2014, 25: 251A.
Chan G.C.W., Yap Y.H.D., Kwan L.P., Chan J.F.W., Iu L.P.L., Wong Y.H.I. and Tang S.C.W., Progressive outer retinal necrosis in a renal transplant recipient: a rare treatment success, Transplant Infectious Disease. 2015, 17: 396-399.


Researcher : CHEN Y
List of Research Outputs

Bao X., Wu H., Zhu X., Guo X., Hutchins A.P., Luo Z., Song H., CHEN Y., Lai K.W.H., Yin M., Xu L., Zhou L., Chen J., Wang D., Qin B., Frampton J., Tse H.F., Pei D., Wang H. and Zhang B., The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters., Cell Res. 2015. 2015, 25(1): 80-92.
WONG C.K.A., CHEN Y., HO L.M., ZHEN Z., Siu D.C.W., Tse H.F. and Yiu K.H., Angiographic result of T-stenting with small protrusion using drug-eluting stents in the management of ischemic side branch: the ARTEMIS study., Nutr Metab Cardiovasc Disorder 2014. 2014.
Yiu K.H., Ng W.S., Chan D., Sit K.Y., Wong A., Lee C.W., Chum H.L., Cheung W.Y., Pun C.T., Ho K.L., CHEN Y., Ho K.M., Kumana C.R., Cheung H.L., Chung M.C., Lau C.P., Au K.W. and Tse H.F., Improved prognosis following renin-angiotensin-aldosterone system blockade in patients undergoing concomitant aortic and mitral valve replacement., Int J Cardiol. 2014. 2014, 177(2): 680-682.


Researcher : CHEN Z
List of Research Outputs

CHEN Z., Cheng K.Y. and Xu A., Adaptor protein APPL1 counteracts streptozotocin-induced diabetes in mice., Diabetes Congress 2015.
CHEN Z., The Adaptor Protein APPL1 Protects Pancreatic β Cells Apoptosis and Hyperglycaemia in Type 1 Diabetes Mellitus., HKU Postgraduate Symposium. 2014.


Researcher : CUI Y
List of Research Outputs

CUI Y., LIANG Y., Ip M.S.M. and Mak J.C.W., Effects of epigallocatechin gallate on smoke-induced oxidative stress and apoptosis in rat lung in vivo, Respirology. 2015, 20 (Supplement 1): 11.
CUI Y., Ip M.S.M. and Mak J.C.W., The role of serotonin homeostasis in airway oxidative stress and inflammation in airway epithelial cells, Am J Respir Crit Care Med. 2015, 191: A1276.
CUI Y., LIANG Y., Ip M.S.M. and Mak J.C.W., Travel Award - Effects of epigallocatechin gallate on cigarette smoke-induced oxidative stress and apoptosis in rat lung in vivo, Airway Vista 2015. 2015.


Researcher : Chai YH
List of Research Outputs

Liang X., Ding Y., Zhang Y., Chai Y.H., He J., Chiu S., GAO F., Tse H.F. and Lian Q., Activation of NRG1-ERBB4 signaling potentiates mesenchymal stem cell-mediated myocardial repairs following myocardial infarction, Cell Death and Disease. 2015, 6: e1765.
Zhang Y., LIANG X., Liao S., Wang W., Wang J.J., LI X., Ding Y., LIANG Y., GAO F., Yang M., Fu Q., Xu A., Chai Y.H., He J., Tse H.F. and Lian Q., Potent Paracrine Effects of human induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Attenuate Doxorubicin-induced Cardiomyopathy, Scientific Reports. 2015, 5: 11235.


Researcher : Chan CYJ
List of Research Outputs

Chan C.Y.J., Assistant Editor, The Hong Kong Journal of Dermatology and Venereology. MEDCOM, 2014.
Chan C.Y.J., Biological Therapy for Psoriasis, Associação de Estudos de Dermatologia e Venereologia de Macau; Macau. 2014.
Chan C.Y.J., Shek S.Y.N., Yeung C.K. and Chan H.H.L., Clinical Efficacy and safety of a novel 755-nm picosecond laser in treatment of pigmentary lesions in Asians, The World Congress of Dermatology 2015 (Vancouver, Canada). 2015.
Chan C.Y.J., Difficult-to-treat Psoriasis; Japanese Psoriasis Academy Meeting 2015 (Tokyo, Japan), Psoriasis Japan Academy. 2015.
Chan C.Y.J., Epidemiology of Psoriasis in East Asia, Japanese Psoriasis Academy Meeting 2015 (Tokyo, Japan), Psoriasis Japan Academy. 2015.
Chan C.Y.J., Yeung C.K., Shek S.Y.N. and Chan H.H.L., Featured Poster Award, The World Congress of Dermatology 2015 (Vancouver, Canada). 2015.
Chan C.Y.J., Psoriasis and Psoriatic Arthropathy in Asia, 2015 Asia Immunology Mediated Inflammatory Disease (IMID) Meeting (Hsinchu, Taiwan); Taiwan Dermatology Association. 2015.
Chan C.Y.J., Hwang Y.Y.G., Trendell-Smith N. and Kwong Y.L., Recalcitrant paraneoplastic pemphigus associated with follicular dendritic cell sarcoma: response to prolonged rituximab and ciclosporin therapy., Internal Medicine Journal. 2014, 44(11): 1145-6.
Chan C.Y.J., Severe Cutaneous Averse Reactions in Hong Kong, T-SCAR Meeting 2015; Taiwan Alliance for Severe Cutaneous Adverse Reactions (T-SCAR). 2015.
Chan C.Y.J., Trendell-Smith N.J., So J.C.C. and Kwong Y.L., Subtle skin involvement in nodal γδ peripheral T-cell lymphoma, The Journal of Dermatology. 2015, 42: 328-330.
SING C.W., Cheung C.L., Wong I.C.K., Cheung B.M.Y., Yeung C.K., Chan H.H.L. and Chan C.Y.J., Toxic Epidermal Necrolysis: Clinical profile, aetiology and treatment in a tertiary hospital over a 16-year period. , Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and the British Pharmacological Society (BPS) Joint Scientific Meeting. 2015.
SING C.W., Cheung C.L., Cheung B.M.Y., Wong I.C.K. and Chan C.Y.J., Toxic epidermal necrolysis: clinical profile in a tertiary hospital over a 15-year period, 19th Research Postgraduate Symposium, December 11, 2014, Hong Kong. 2014.
Shek S.Y.N., Chan C.Y.J., Yeung C.K. and Chan H.H.L., Clinical efficacy and safety of a novel dual wavelength 532/1064-nm picosecond laser in treatment of pigmentary lesions in Asians, The World Congress of Dermatology 2015 (Vancouver, Canada). 2015.
Shek S.Y.N., Yeung C.K., Chan P.Y.N., Chan C.Y.J. and Chan H.H.L., Evaluating the safety and efficacy of the 1,440-nm laser in the treatment of photodamage in Asian skin., In: Wiley, Lasers in Surgery and Medicine . Wiley Online Library, 2014, 46: 375-9.
Shek S.Y.N., Chan C.Y.J., Yeung C.K. and Chan H.H.L., THE EFFICACY OF A SECOND GENERATION FOCUSED ULTRASOUND COMBINED WITH RADIOFREQUENCY FOR BODY CONTOURING IN CHINESE, The World Congress of Dermatology 2015 (Vancouver, Canada). 2015.
Shih K.C., Yim S.M., Chan C.Y.J., Chan K.S.K., Lai J.S.M. and Yuen L.H., Early Bilateral Amniotic Membrane Transplantation in the Management of Severe Ocular Involvement from Acute Toxic Epidermal Necrolysis in a Chinese Pediatric Patient, Journal of Clinical and Experimental Ophthalmology. 2014, 5:358.


Researcher : Chan DTM
Project Title:Provision of HBVDNA assays for immunosuppressed HBsAg-positive kidney transplant recipients and patients with kidney diseases
Investigator(s):Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:07/2010


Project Title:The Role of Annexin II in the Regulation of Inflammation and Fibrosis in Lupus Nephritis
Investigator(s):Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2013


Project Title:The role of connective tissue growth factor in the pathogenesis of lupus nephritis
Investigator(s):Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:05/2013
Completion Date:04/2015


Project Title:Gut Microbiota Products in the Pathogenesis of Lupus Nephritis
Investigator(s):Chan DTM, Yung SSY, Yap YHD
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2014


Project Title:The Role of CD44 in the Pathogenesis of Lupus Nephritis
Investigator(s):Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2014


Project Title:The role of hepatocyte growth factor in lupus nephritis
Investigator(s):Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:05/2014


Project Title:Kidney Week 2014; Increased Synthesis of CD44s and its Variants in Kidney Fibrosis of Lupus Nephritis
Investigator(s):Chan DTM
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:11/2014
Completion Date:11/2014


Project Title:The role of Ku70 and Ku80 in the pathogenesis of lupus nephritis
Investigator(s):Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2015


Project Title:Measurement of inflammatory and fibrotic mediators in serum and their association with vascular injury in patients with lupus nephritis
Investigator(s):Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:05/2015


Project Title:The Role of Major Vault Protein in Tubulo-interstitial Injury during Lupus Nephritis
Investigator(s):Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:06/2015


List of Research Outputs

Chan D.T.M., Au K.Y., MA X., Tse W.W., Chau K.M. and Yung S.S.Y., CD44 expression in serum and kidney correlates with disease activity in lupus nephritis, 52nd European Renal Association/European Dialysis Transplantation Association Congress. 2015.
Chan D.T.M., Tse W.W., Chau K.M. and Yung S.S.Y., Increased Synthesis of CD44s and its Variants in Kidney Fibrosis of Lupus Nephritis, American Society of Nephrology Kidney Week 2014.
Chan D.T.M., Au K.Y., MA X., Tse W.W., Chau K.M. and Yung S.S.Y., Serum and renal expression of CD44s and its variants correlate with disease activity in lupus nephritis, World Congress of Nephrology 2015.
Chan D.T.M., Treatment of severe lupus nephritis: the new horizon, Nature Reviews Nephrology. 2015, 11(1): 46-61 [Epub 5 Nov 2014. Review].
Chen J.Y., Tsang J.P.Y., Lui S.L., Lo W.K., Tang S.C.W., Chan D.T.M. and Lam C.L.K., The illness experience of end stage renal disease patients in Hong Kong undergoing hemodialysis, Communication, Ethics and Medicine (COMET) conference. 2015.
Cheung K.F., Yung S.S.Y., Yim A.S.Y., Chau K.M., Yap Y.H.D. and Chan D.T.M., Annexin II-binding IgG and IgM in sera of patients with lupus nephritis, 3rd International Conference on Immune Tolerance 2014.
Chu J.Y.S., Yung S.S.Y., Chau K.M., Kam K.M. and Chan D.T.M., MicroRNA-200c inhibits TGF-β1-induced epithelial-to-mesenchymal transition and fibrogenesis in mesothelial cells, Gordon Research Conference - Fibronectin, Integrins & Related Molecules. 2015.
Deng X., Su Y., Wu H., Wu R., Zhang P., Dai Y., Chan D.T.M., Zhao M. and Lu Q., The role of microRNAs in autoimmune diseases with skin involvement, Scand J Immunol. 2015, 81(3): 153-165. Review.
Ip K.M., Yung S.S.Y., Chan D.T.M., Tsao G.S.W. and Wong A.S.T., p70 S6 kinase drives ovarian cancer metastasis through multicellular spheroid-peritoneum interaction and P-cadherin/beta1 integrin signaling activation, Oncotarget. 2014, 5: 9133-9149.
JIANG N., Yung S.S.Y., Chau K.M., Zhang Q. and Chan D.T.M., Decorin Suppresses Mesothelial Cell Epithelial-to-Mesenchymal Transition, 15th Congress of the International Society for Peritoneal Dialysis. 2014.
LI N., Chau K.M., Kam K.M., Chan D.T.M. and Yung S.S.Y., Peritonitis Induces Native and EDA+ Fibronectin Expression in Peritoneal Mesothelial Cells Via TGF-beta1 and PI3K and MAPK Activation, Gordon Research Conference Fibronectin, Integrins & Related Molecules. 2015.
Liu Y., Liao J., Zhao M., Wu H., Yung S.S.Y., Chan D.T.M., Yoshimura A. and Lu Q., Increased expression of TLR2 in CD4+ T cells from SLE patients enhances immune reactivity and promotes IL-17 expression through histone modifications , European Journal of Immunology. 2015, 45(9): 2683-2693.
Luo S., Liu Y., Liang G., Zhao M., Wu H., Liang Y., Qiu X., Tan Y., Dai Y., Yung S.S.Y., Chan D.T.M. and Lu Q., The role of microRNA-1246 in the regulation of B cell activation and the pathogenesis of systemic lupus erythematosus, Clinical Epigenetics. 2015, 7: 24.
Ngalamika O., Liang G., Zhao M., Yu X., Yang Y., Yin H., Liu Y., Yung S.S.Y., Chan D.T.M. and Lu Q., Peripheral whole blood FOXP3 TSDR methylation: a potential marker in severity assessment of autoimmune diseases and chronic infections, Immunol Invest. 2014, 44(2): 126-136 [Epub a Aug 2014].
Shea Y.F., Lam M.F., Lee M.S., Mok T.M.Y., Lui S.L., Yip T.P.S., Lo W.K., Chu L.W. and Chan D.T.M., Prevalence of CMMSE defined cognitive impairment among peritoneal dialysis patients and its impact on peritonitis, Clinical And Experimental Nephrology. 2015, 21 May 2015: Epub ahead of print.
Shum H.P., Leung N.Y., Chang L.L., Tam O.Y., Kwan A.M., Chan K.C., Yan W.W. and Chan D.T.M., Predictive value of plasma neutrophil gelatinase-associated lipocalin for acute kidney injury in intensive care unit patients after major non-cardiac surgery, Nephrology (Carlton). 2015, 20(5): 375-382.
Shum H.P., Yan W.W. and Chan D.T.M., Risks and benefits of citrate anticoagulation for continuous renal replacment therapy, Hong Kong Medical Journal. 2015, 21(2): 149-154 [Epub 5 Dec 2014. Review].
Tsun J.G.S., Yung S.S.Y., Chau K.M., Shiu S.W.M., Chan D.T.M. and Tan K.C.B., Cellular cholesterol transport proteins in diabetic nephropathy, PLoS One. 2014, 9(9): e105787.
Yang Y., Tang Q., Zhao M., Liang G., Wu H., Li D., Xie Y., Tan Y., Dai Y., Yung S.S.Y., Chan D.T.M. and Lu Q., The effect of mycophenolic acid on epigenetic modifications in lupus CD4+ T cells, Clinical Immunology. 2015, 158: 67-76.
Yap Y.H.D., Ma K.M.M., Mok M.M., Kwan L.P., Chan G.C. and Chan D.T.M., Long-term data on tacrolimus treatment in lupus nephritis, Rheumatology. Oxford, 2014, 53(12): 2232-2237 [Epub 4 Jul 2014].
Yap Y.H.D., Yung S.S.Y., Zhang Q., Tang S.O.C. and Chan D.T.M., Mesangial cell-binding activity of serum immunoglobulin G in patients with lupus nephritis, PLoS One. 2014, 9(7): e101987.
Yung S.S.Y., Ng C.Y., Ho S.K., Cheung K.F., Chan K.W., Zhang Q., Chau K.M. and Chan D.T.M., Anti-dsDNA antibody induces soluble fibronectin secretion by proximal renal tubular epithelial cells and downstream increase of TGF-β1 and collagen synthesis, Journal of Autoimmunity. 2015, 58: 111-122.
Yung S.S.Y., JIANG N., Chau K.M., Zhang Q. and Chan D.T.M., Decorin Ameliorates Peritoneal Fibrosis in Peritoneal Dialysis Related Peritonitis, American Society of Nephrology Kidney Week 2014.
Yung S.S.Y., Lui S.L., Ng K.F., Yim A.S.Y., Ma K.M.M., Lo W.K., Chow C.C., Chu K.H., Chak W.L., Lam M.F., Yung C.Y., Yip T.P.S., Wong S., Tang S.O.C., Ng F.S.K. and Chan D.T.M., Impact of a Low-Glucose Peritoneal Dialysis Regimen on Fibrosis and Inflammation Biomarkers, Peritoneal Dialysis International. 2015, 35: 147-158.
Yung S.S.Y., Tse W.W., Chau K.M. and Chan D.T.M., Inhibition of Hyaluronan Synthesis in NZBWF1/J Mice Decreased Glomerular Deposition of Fibronectin and Collagen and Improved Renal Function, Gordon Research Conference Fibronectin, Integrins & Related Molecules. 2015.
Zhang Y., ZHANG J., Yang J., WANG Y., ZHANG L., Zuo X., Sun L., Pan H.F., Hirankarn N., WANG T., CHEN R., Ying D., Shen J.J., Lee T.L., Lau W.C.S., Chan D.T.M., Leung A.M.H., Mok C.C., Wong S.N., Lee K.W., Ho M.H.K., Lee P.P.W., Chung B.H.Y., Chong C.Y., Wong R.W.S., Mok T.M.Y., Wong W.H.S., Tong K.L., Tse N.K.C., Li X.P., Avihingsanon Y., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Shotelersuk V., Ying S.K.Y., Fung S.K.S., Lai W.M., Wong C.M., Ng I.O.L., Garcia-Barcelo M.M., Cherny S.S., Tam P.K.H., Sham P.C., Yang S., Ye D.Q., Cui Y., Zhang X.J., Lau Y.L. and Yang W., Meta-analysis of GWAS on two Chinese populations followed by replication identifies novel genetic variants on the X chromosome associated with systemic lupus erythematosus, Human Molecular Genetics. 2015, 24(1): 274-284.
Zhao M., Liu S., Luo S., Wu H., Tang M., Cheng W., Zhang Q., Zhang P., Yu X., Xia Y., Yi N., Gao F., Wang L., Yung S.S.Y., Chan D.T.M., Sawalha A.H., Richardson B., Gershwin M.E., Li N. and Lu Q., DNA methylation and mRNA and microRNA expression of SLE CD4+ T cells correlate with disease phenotype, J Autoimmun. 2014, 54: 127-136 [Epub 3 Aug 2014].


Researcher : Chan HHL
Project Title:The role of epidermal cooling in improving the outcome of laser therapy in the treatment of Nevus of Ota
Investigator(s):Chan HHL, Lam LK
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2000


Project Title:The use of vascular lasers in the treatment of port wine stain in chinese
Investigator(s):Chan HHL, Wei WI
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:11/2001


List of Research Outputs

Chan C.Y.J., Shek S.Y.N., Yeung C.K. and Chan H.H.L., Clinical Efficacy and safety of a novel 755-nm picosecond laser in treatment of pigmentary lesions in Asians, The World Congress of Dermatology 2015 (Vancouver, Canada). 2015.
Chan C.Y.J., Yeung C.K., Shek S.Y.N. and Chan H.H.L., Featured Poster Award, The World Congress of Dermatology 2015 (Vancouver, Canada). 2015.
Chan H.H.L., Yeung C.K. and Shek S.Y.N., Featured Poster Award, The World Congress of Dermatology (2015); Vancouver, Canada.. 2015.
SING C.W., Cheung C.L., Wong I.C.K., Cheung B.M.Y., Yeung C.K., Chan H.H.L. and Chan C.Y.J., Toxic Epidermal Necrolysis: Clinical profile, aetiology and treatment in a tertiary hospital over a 16-year period. , Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and the British Pharmacological Society (BPS) Joint Scientific Meeting. 2015.
Shek S.Y.N., Chan C.Y.J., Yeung C.K. and Chan H.H.L., Clinical efficacy and safety of a novel dual wavelength 532/1064-nm picosecond laser in treatment of pigmentary lesions in Asians, The World Congress of Dermatology 2015 (Vancouver, Canada). 2015.
Shek S.Y.N., Yeung C.K., Chan P.Y.N., Chan C.Y.J. and Chan H.H.L., Evaluating the safety and efficacy of the 1,440-nm laser in the treatment of photodamage in Asian skin., In: Wiley, Lasers in Surgery and Medicine . Wiley Online Library, 2014, 46: 375-9.
Shek S.Y.N., Yeung C.K. and Chan H.H.L., Featured Poster Award, The World Congress of Dermatology 2015 (Vancouver, Canada). 2015.
Shek S.Y.N., Chan C.Y.J., Yeung C.K. and Chan H.H.L., THE EFFICACY OF A SECOND GENERATION FOCUSED ULTRASOUND COMBINED WITH RADIOFREQUENCY FOR BODY CONTOURING IN CHINESE, The World Congress of Dermatology 2015 (Vancouver, Canada). 2015.


Researcher : Chan HWF
List of Research Outputs

Chan T.C.I., Hung I.F.N., Chan K.H., Li P.Y., Li T.W., Luk J.K.H., Chu L.W. and Chan H.W.F., A Randomized Controlled Trial to Compare Immunogenicity Between Intramuscular and Intradermal Trivalent Influenza Vaccination in Nursing Home Older Adults, 20th Medical Research Conference, The University of Hong Kong, 17 Jan 2015.. 2015.
Chan T.C.I., Hung I.F.N., Luk J.K.H., Chu L.W. and Chan H.W.F., Comparing Effectiveness Between Intramuscular and Intradermal Trivalent Influenza Vaccination in Nursing Home Residents: A Randomized Controlled Trial, 20th Medical Research Conference, The University of Hong Kong, 17 Jan 2015. (Oral presentation). 2015.
Chan T.C.I., Hung I.F.N., Chan K.H., Li P.Y., Li T.W., Luk J.K.H., Chu L.W. and Chan H.W.F., Local Adverse Effect of Intradermal and Administration of Influenza Vaccination is an Indicator of Satisfactory Immunogenicity, 20th Medical Research Conference 2015, The University of Hong Kong, 17 Jan 2015. . 2015.
Chan T.C.I., Hung I.F.N., Luk J.K.H., Chu L.W. and Chan H.W.F., Prevalence of Influenza Vaccination and Associated Factors Among Chinese Nursing Home Health Care Workers, 20th Medical Research Conference 2015, The University of Hong Kong, 17 Jan 2015.. 2015.
Kwan S.K.J., Chu L.W., Chan H.W.F., Lee T.M.C., Law A.C.K., Mak H.K.F., Cheung R.T.F., Chang R.C.C., Lum T.Y.S. and Tang S.C.W., Comparing vascular dementia and Alzheimer’s dementia: a preliminary, cross-sectional, multimodal comparative study evaluating clinical and cognitive profile, neuroimaging, biomarkers and quantitative EEG ($240,000), Seed Funding HKU. 2014.


Researcher : Chan JCK
Project Title:Application of the APACHE II and III prognostic scoring methods in the 14-bed Intensive Care Unit at Queen Mary Hospital
Investigator(s):Chan JCK, Lam WK
Department:Medicine
Source(s) of Funding:Health Services Research Fund - Full Grants
Start Date:07/1995




Researcher : Chan K
List of Research Outputs

Chan V.N.Y., Lai C.L., Chan K. and Yuen R.M.F., Hepatitis B virus array for genotyping and mutation detection, Hong Kong Medical Journal. 2014, 20(6): Suppl 6: 25-7.


Researcher : Chan KH
Project Title:Clinical outcome of multiple sclerosis in Hong Kong Chinese
Investigator(s):Chan KH
Department:Medicine
Source(s) of Funding:Bayer Pharmaceuticals Ltd. - General Award
Start Date:01/2008


Project Title:Study of clinical and immunological characteristics of local multiple sclerosis patients
Investigator(s):Chan KH, Ho SL
Department:Medicine
Source(s) of Funding:Bayer Pharmaceuticals Ltd. - General Award
Start Date:03/2008


Project Title:The role of Interleukin-17 a nd Interleukin-23 and magnetic resonance findings during relapse of multiple sclerosis and neuromyelitis optica
Investigator(s):Chan KH, Ho WL
Department:Medicine
Source(s) of Funding:Bayer Pharmaceuticals Ltd. - General Award
Start Date:04/2009


Project Title:Study of potential neuroprotective role of adiponectin and APPL1 in beta-amyloid neurotoxicity
Investigator(s):Chan KH, Lam KSL, Xu A, Ho SL, Ho WL
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2010


Project Title:Study of immunopathogenesis of multiple sclerosis and neuromyelitis optica
Investigator(s):Chan KH, Ho WL
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:06/2011


Project Title:Adiponectin gene therapy in mouse model of Alzheimer’s disease (CRF)
Investigator(s):Chan KH
Department:Medicine
Source(s) of Funding:Seed Funding for Incubating Group-based Collaborative Research Projects
Start Date:01/2015


List of Research Outputs

Chan K.H., Adiponectin in Dementia, 5th International Alzheimer’s Disease Conference. 2015. Hong Kong. 2015.
Chan K.H., Anti-platelet Drugs In Stroke Prevention, Hong Kong College of Physicians Annual Scientific Meeting 2014. 2014.
Chan K.H., Central Nervous System Infection: True or False, Grand Round, University Department of Medicine. 2014.
Chan K.H., Chairman of Multiple Sclerosis Expert Meeting For South East Asia - Personalizing the treatment in modern MS - , Hong Kong Multiple Sclerosis Society. 2014.
Chan K.H., Chairman, Asia Pacific Regional Conference on Multiple Sclerosis, Hong Kong Multiple Sclerosis Society. 2014.
Chan K.H., Clinical Aspects Of Neurological Diseases, Hospital Authority Central Commissioned Training Programme 2014 Immunopatholgy Update: Autoimmunity And Immunophenotyping. 2014.
Chan K.H., Clinical Features Of Autoimmune Myasthenia Gravis And Neuromyelitis Optica Spectrum Disorders, Hospital Authority Central Commissioned Training Programme 2014 Immunopathology Update: Autoimmunity And Immunophenotyping. 2014.
Chan K.H., New Understanding and Management Of Migraine, "Explore the World of Medicine" Public Lecture Series 2014. 2014.
Chan K.H., Twenty-Year Service Award, Hong Kong University-Hospital Authority Hong Kong West Cluster. 2014.
Guo Y., Chung S.K., Siu D.C.W., Kwan S.C., Ho W.L., Yeung P.K.K. and Chan K.H., Endothelin-1 overexpression exacerbate experimental allergic encephalomyelitis, Journal of Neuroimmunology. 2014.
Ho C.W., Ho M.H., Chan P.H.M., Hai S.H.J.J., Cheung E., Yeung C.Y., Lau G.K.K., Chan K.H., Lau C.P., Lip G.Y., Leung G.K.K., Tse H.F. and Siu D.C.W., Ischemic stroke and intracranial hemorrhage with aspirin, dabigatran, and warfarin: impact of quality of anticoagulation control, Stroke. 2015.
Ho M.H., Ho C.W., Cheung E., Chan P.H.M., Hai J.J., Chan K.H., Chan E.W., Leung G.K.K., Tse H.F. and Siu D.C.W., Continuation of Dabigatran Therapy in “Real-World” Practice in Hong Kong, PLoS ONE. 2014, 9(8): e101245.
Kremar S., Renard F., Achard S., Lana-Peixoto M., Asgari N., Klawiter E.C., Tenembaum S., Banwell B., Greenberg B., Bennett J.L., Levy M., Villoslada P., Saiz A., Fujihara K., Chan K.H., Schippling S., Paul F., Kim H.J., de Seze J. and Wuerfel J., Advanced MRI in neuromyelitis optica spectrum disorders, JAMA Neurology. 2015.
Lau G.K.K., Chan L.K., Li O.Y., Yuen T.K., Wong Y.K., Chan K.H., Chan J.F.W., Chang S.K.R., Cheung R.T.F., Doherty I., Ho S.L., Hon F.K.S., Kwan S.K.J., Lee R., Leung G.K.K., Mak W., Mak H.K.F., Shih K.C. and Tsang C.O.A., Establishing an eLearning Platform in Clinical Neurosciences, East-West Alliance Global Symposia 2014.
Lau G.K.K., Wong Y.K., Chan Y.H., Li O.Y., Lee P.Y.S., Yuen G.G., Wong Y.K., Tong S., Wong D. and Chan K.H., Mediterranean-Style Diet Is Associated With Reduced Blood Pressure Variability and Subsequent Stroke Risk in Patients With Coronary Artery Disease, American Journal of Hypertension. 2015, 28: 501-507.
Lau G.K.K., Chan L.K., Chan K.H., Chang S.K.R., Chang R.C.C., Cheung R.T.F., Doherty I., Ho S.L., Hon S.F.K., Kwan S.K.J., Lee R., Leung G.K.K., Mak W., Shih K.C. and Tsang C.O.A., ePoster Award (First Prize), Title: Establishing an eLearning Platform in Clinical Neurosciences at HKU, HKU Li Ka Shing Faculty of Medicine Frontiers Series – East-West Alliance Global Symposia. 2014.
Lee J.C., Pang S.Y., Lam C.L.D., Tse A.C., Lau G.K.K., Chang S.K.R., Ho S.L., Cheung R.T.F., Mak W., Hon F.K.S., Chang C.K., Teo K.L. and Chan K.H., Myasthenic crisis in patients with generalised myasthenia gravis. Hong Kong Academy of Medicine, 2014., 2015.
Lee J.C.Y., Pang S.Y.Y., Tse C.T.A., Lau G.K.K., Chang S.K.R., Teo K.C. and Chan K.H., Thymomatous myasthenia gravis in Hong Kong Chinese, 20th Medical Research Conference, Department of Medicine, HKU. 2015.
Ng C.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Lam K.S.L., Xu A. and Chan K.H., Adiponectin deficiency induced cognitive dysfunction and Alzheimer’s disease pathogenesis in mice through the disruption of insulin sensitivity and inactivated AMPK signaling , 67th American Academy of Neurology Annual Meeting. 2015.
Ng C.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Lam K.S.L., Xu A. and Chan K.H., Research Travel Scholarship 2015, American Academy of Neruology. 2015.
So J.C.C., Chan K.H., Pang A.W.K., Chan J.K.F. and Kwong Y.L., Diganosis of brainstem involvement in NK/T cell lymphoma, Annals of Hematology. 2014, 93: 1433.


Researcher : Chan KWK
List of Research Outputs

Lee S.W.L., Lam S.C.C., Kong S.L., Chan K.W.K., Tam C.C., Wong K.L., Wong A.Y.T., Yung A.S.Y., Shea C.P., Zhang L. and Wu K.Y.K., TCT-367 2-Year Sequential OCT Follow-up Findings and 3-Year Clinical Outcomes of the New Dual Therapy Endothelial Progenitor Cell Capturing Sirolimus-eluting COMBO Stent: The EGO-COMBO Study, Journal of the American College of Cardiology. 2014, 64: B107.


Researcher : Chan MMW
Project Title:A surveillance program of tuberculosis in old age homes in Hong Kong
Investigator(s):Chan MMW, Chu LW, Lam WK
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:11/2001


Project Title:A surveillance program of tuberculosis in old age homes in Hong Kong
Investigator(s):Chan MMW, Chu LW, Lam WK
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2004




Researcher : Chan P
List of Research Outputs

Yau T.C.C., Cheng N.P., Chan P., Chen L., Yuen J., Pang R.W.C., Fan S.T., Wheatley D.N. and Poon R.T.P., Preliminary efficacy, safety, pharmacokinetics, pharmacodynamics and quality of life study of pegylated recombinant human arginase 1 in patients with advanced hepatocellular carcinoma, Investigational New Drugs. 2015, 33(2): 496-504.


Researcher : Chan PHM
Project Title:Left Atrial Volume by Computed Tomography in prediction of New onset Atrial Fibrillation
Investigator(s):Chan PHM, Siu DCW, She HLH
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:01/2015


List of Research Outputs

Chan P.H.M. and Tse H.F., Adoption of Cardiac Resynchronization Therapy in Heart Failure Patients with Post-Cardiac Valve Surgery or Interventions?, Journal of Cardiovascular Electrophysiology. 2014, n/a-n/a.
Chan P.H.M., Li W., Hai S.H.J.J., Tse H.F. and Siu D.C.W., Impact of Antithrombotic Therapy in Atrial Fibrillation on the Presentation of Coronary Artery Disease, PLOS ONE. 2015, 10: e0131479.
Chan P.H.M., Hai S.H.J.J. and Siu D.C.W., Response to Letter Regarding Article, "Ischemic Stroke and Intracranial Hemorrhage With Aspirin, Dabigatran, and Warfarin: Impact of Quality of Anticoagulation Control", Stroke. 2015, 46: e72-e72.
Hai S.H.J.J., Chan P.H.M., Tse H.F. and Siu D.C.W., Slow Heart Rate Predicts New Occurrence of Atrial Fibrillation, Heart, Lung and Circulation. 2015.
Ho C.W., Ho M.H., Chan P.H.M., Hai S.H.J.J., Cheung E., Yeung C.Y., Lau G.K.K., Chan K.H., Lau C.P., Lip G.Y., Leung G.K.K., Tse H.F. and Siu D.C.W., Ischemic stroke and intracranial hemorrhage with aspirin, dabigatran, and warfarin: impact of quality of anticoagulation control, Stroke. 2015.
Ho M.H., Ho C.W., Cheung E., Chan P.H.M., Hai J.J., Chan K.H., Chan E.W., Leung G.K.K., Tse H.F. and Siu D.C.W., Continuation of Dabigatran Therapy in “Real-World” Practice in Hong Kong, PLoS ONE. 2014, 9(8): e101245.


Researcher : Chan PYN
List of Research Outputs

Shek S.Y.N., Yeung C.K., Chan P.Y.N., Chan C.Y.J. and Chan H.H.L., Evaluating the safety and efficacy of the 1,440-nm laser in the treatment of photodamage in Asian skin., In: Wiley, Lasers in Surgery and Medicine . Wiley Online Library, 2014, 46: 375-9.


Researcher : Chan SYT
List of Research Outputs

Chan S.Y.T., Hwang Y.Y.G., Singh G.H.H., Cheung C.W.S., Ting A.C.W., Beh S.L., Kwong Y.L. and Tse E.W.C., Increasing incidence of venous thromboembolism due to cancer-associated thrombosis in Hong Kong Chinese, Thrombosis Research. 2014.
Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Liu S.H.K., Singh G.H.H., Lam Y.F., Fung J.Y.Y., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., A prospective study of hepatitis B reactivation in patients with prior HBV exposure undergoing hematopoietic stem cell transplantation: Reactivation association with graft-versus-host disease, Oral presentation at the International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2015, 62(Suppl 2): S194.
Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Hepatitis B reactivation in patients with prior HBV exposure undergoing rituximab-containing chemotherapy for lymphoma: a prospective study, Journal of Clinical Oncology. 2014, 32(33): 3736-43.


Researcher : Chan TCI
List of Research Outputs

Chan T.C.I., Hung I.F.N., Chan K.H., Li P.Y., Li T.W., Luk J.K.H., Chu L.W. and Chan H.W.F., A Randomized Controlled Trial to Compare Immunogenicity Between Intramuscular and Intradermal Trivalent Influenza Vaccination in Nursing Home Older Adults, 20th Medical Research Conference, The University of Hong Kong, 17 Jan 2015.. 2015.
Chan T.C.I., Hung I.F.N., Luk J.K.H., Chu L.W. and Chan H.W.F., Comparing Effectiveness Between Intramuscular and Intradermal Trivalent Influenza Vaccination in Nursing Home Residents: A Randomized Controlled Trial, 20th Medical Research Conference, The University of Hong Kong, 17 Jan 2015. (Oral presentation). 2015.
Chan T.C.I., Hung I.F.N., Chan K.H., Li P.Y., Li T.W., Luk J.K.H., Chu L.W. and Chan H.W.F., Local Adverse Effect of Intradermal and Administration of Influenza Vaccination is an Indicator of Satisfactory Immunogenicity, 20th Medical Research Conference 2015, The University of Hong Kong, 17 Jan 2015. . 2015.
Chan T.C.I., Hung I.F.N., Luk J.K.H., Chu L.W. and Chan H.W.F., Prevalence of Influenza Vaccination and Associated Factors Among Chinese Nursing Home Health Care Workers, 20th Medical Research Conference 2015, The University of Hong Kong, 17 Jan 2015.. 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Best Abstract in Clinical Medicine (Oral) - "Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial", 20th Medical Research Conference 2015, Department of Medicine, The University of Hong Kong . 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial, 20th Medical Research Conference, The University of Hong Kong, 17 Jan 2015. (Oral presentation - Best abstract in Clinical Medicine) . 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial, Clinical Infectious Diseases . 2014, 59(9): 1246-55.


Researcher : Chan TY
List of Research Outputs

Chin W.Y., Lam C.L.K., Chan T.Y. and Wan Y.F., Distinguished Paper Award, North American Primary Care Research Group (NAPCRG). 2014.


Researcher : Chan VNY
Project Title:Hepatitis B virus array for genotyping and mutation detection
Investigator(s):Chan VNY, Lai CL, Chan K, Yuen RMF
Department:Medicine
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:11/2006


List of Research Outputs

Chan V.N.Y., Lai C.L., Chan K. and Yuen R.M.F., Hepatitis B virus array for genotyping and mutation detection, Hong Kong Medical Journal. 2014, 20(6): Suppl 6: 25-7.


Researcher : Chan VSF
Project Title:Functional characterization of the novel C-type lectin-like receptor CLEC16A and its expression association in systemic lupus erythematosus
Investigator(s):Chan VSF, Lau WCS
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2011
Completion Date:09/2014


Project Title:Intracellular dynamics of CLEC16A
Investigator(s):Chan VSF, Yan S
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2014
Completion Date:05/2015


Project Title:Proteomic analysis of CLEC16A interacting partners in autophagy
Investigator(s):Chan VSF, Tam CY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2015


List of Research Outputs

Chan V.S.F., C-Type Lectin Receptors in Antimicrobial Immunity, Croucher Summer Course 2014: Advances in Immunology in Health and Disease. 2014.
Chan V.S.F., Editorial Board Member, International Journal of Molecular Sciences. Basel, Switzerland, MPDI AG, 2015, Molecular Diagnostics.
Chan V.S.F., Guest Editor, International Journal of Molecular Sciences. Basel, Switzerland, MDPI AG, 2014.
TAM C.Y., Yang W., Lau W.C.S. and Chan V.S.F., Systemic Lupus Erythematosus Patients Exhibit Reduced Expression of CLEC16A Isoforms in Peripheral Leukocytes, International Journal of Molecular Sciences. Basel, Switzerland, MDPI AG, 2015, 16: 14428-14440.


Researcher : Chan WK
List of Research Outputs

WU H., Lo Y., LUK T.W., Chan W.K. and Mok T.M.Y., Bone marrow derived dendritic cells modified by lentiviral-mediated RelB shRNA possess tolerogenic phenotype and functions on lupus splenic lymphocytes. European League of Association of Rheumatology (EULAR) 2015. Ann Rheum Dis 2015; 74(Suppl2), 2015, 74(Suppl2): 951.


Researcher : Chan WS
List of Research Outputs

Kong S.L., Lee S.W.L., Lui G.C.S., Chan W.S., Fok A.K.T., Lee H.P. and Wu K.Y.K., VALIDATION OF ACCURACY OF HOME BLOOD PRESSURE MONITORING DEVICES BY BLAND AND ALTMAN LIMITS OF AGREEMENT AND METHOD OF VARIANCE ESTIMATES RECOVERY, Journal of the American College of Cardiology. 2015, 65: A1406.
Santoso T., Siu D.C.W., Irawan C., Chan W.S., Alwi I., Yiu K.H., Aziz A., Kwong Y.L. and Tse H.F., Endomyocardial Implantation of Autologous Bone Marrow Mononuclear Cells in Advanced Ischemic Heart Failure: a Randomized Placebo-Controlled Trial (END-HF)., J Cardiovasc Transl Res. 2014.


Researcher : Chan YCC
Project Title:DPP-4 inhibition protects diabetes-induced impairment in EPC function and vascular repair
Investigator(s):Chan YCC, Xu A
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:06/2013
Completion Date:11/2014


List of Research Outputs

KWOK H.M., Cheng K.Y., Li F.Y.L., Chan Y.C.C., Hoo R.L.C., Ye D., Xu A. and Lam K.S.L., Inactivation of c-Jun N-terminal Kinase in Adipose Tissue Alleviates Atherosclerosis in Diet-induced Obese ApoE-deficient Mice, 83rd European Atherosclerosis Society Congress. 2015.
Lam K.S.L., Chan Y.C.C., Stillitano A., Wong C.M., Pang Y. and Xu A., Adipose tissue FGF21 resistance contributes to hypoadiponectinemia and insulin resistance in obesity: Role of miR-34a, The 75th Scientific Sessions of the American Diabetes Association, 5-9 Jun 2015, Boston, USA. 2015.


Researcher : Chan YY
List of Research Outputs

LI R., Yiu W.H., Wu H., LIN M., WONG W.L.D., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., BMP7 Reduces Tubular Inflammation and Oxidative Stress in Diabetic Nephropathy, J Am Soc Nephrol. 2014, 25: 216A.
LI R., Yiu W.H., Wu H., WONG W.L.D., Chan Y.Y., LIN M., Leung J.C.K., Lai K.N. and Tang S.C.W., BMP7 reduces inflammation and oxidative stress in diabetic tubulopathy, Clinical Science [IF 5.629]. 2015, 128(4): 269-280.
Lim A.I., Chan Y.Y., Tang S.C.W., Lai K.N. and Leung J.C.K., Albumin and glycated albumin activate KIM-1 release in tubular epithelial cells through distinct kinetics and mechanisms, Inflammation Research [Epub ahead of print]. 2014.
Yiu W.H., WONG W.L.D., Leung J.C.K., Chan Y.Y., Lai K.N. and Tang S.C.W., Thrombin Induces Epithelial-Mesenchymal Transition Through the Activation of PAR-1 in Tubular Epithelial Cells, J Am Soc Nephrol. 2014, 25: 730A.


Researcher : Chang SKR
List of Research Outputs

Lau G.K.K., Chan L.K., Li O.Y., Yuen T.K., Wong Y.K., Chan K.H., Chan J.F.W., Chang S.K.R., Cheung R.T.F., Doherty I., Ho S.L., Hon F.K.S., Kwan S.K.J., Lee R., Leung G.K.K., Mak W., Mak H.K.F., Shih K.C. and Tsang C.O.A., Establishing an eLearning Platform in Clinical Neurosciences, East-West Alliance Global Symposia 2014.
Lau G.K.K., Chan L.K., Chan K.H., Chang S.K.R., Chang R.C.C., Cheung R.T.F., Doherty I., Ho S.L., Hon S.F.K., Kwan S.K.J., Lee R., Leung G.K.K., Mak W., Shih K.C. and Tsang C.O.A., ePoster Award (First Prize), Title: Establishing an eLearning Platform in Clinical Neurosciences at HKU, HKU Li Ka Shing Faculty of Medicine Frontiers Series – East-West Alliance Global Symposia. 2014.
Lee J.C., Pang S.Y., Lam C.L.D., Tse A.C., Lau G.K.K., Chang S.K.R., Ho S.L., Cheung R.T.F., Mak W., Hon F.K.S., Chang C.K., Teo K.L. and Chan K.H., Myasthenic crisis in patients with generalised myasthenia gravis. Hong Kong Academy of Medicine, 2014., 2015.
Lee J.C.Y., Pang S.Y.Y., Tse C.T.A., Lau G.K.K., Chang S.K.R., Teo K.C. and Chan K.H., Thymomatous myasthenia gravis in Hong Kong Chinese, 20th Medical Research Conference, Department of Medicine, HKU. 2015.
Yao N., Cheung C., Pang S.Y.Y., Chang S.K.R., Lau G.K.K., Suckling J., Yu K., Mak H.K.F., Chua S.E., Ho S.L. and McAlonan G.M., Multimodal MRI of the hippocampus in Parkinson's disease with visual hallucinations, Brain Structure and Function. 2014.
Yao N., Pang S., Cheung C., Chang S.K.R., Lau G.K.K., Suckling J., Yu K., Mak H.K.F., McAlonan G., Ho S.L. and Chua S.E., Resting activity in visual and corticostriatal pathways in Parkinson’s disease with hallucinations, Parkinsonism and Related Disorders. 2015.


Researcher : Chau KM
List of Research Outputs

Chan D.T.M., Au K.Y., MA X., Tse W.W., Chau K.M. and Yung S.S.Y., CD44 expression in serum and kidney correlates with disease activity in lupus nephritis, 52nd European Renal Association/European Dialysis Transplantation Association Congress. 2015.
Chan D.T.M., Tse W.W., Chau K.M. and Yung S.S.Y., Increased Synthesis of CD44s and its Variants in Kidney Fibrosis of Lupus Nephritis, American Society of Nephrology Kidney Week 2014.
Chan D.T.M., Au K.Y., MA X., Tse W.W., Chau K.M. and Yung S.S.Y., Serum and renal expression of CD44s and its variants correlate with disease activity in lupus nephritis, World Congress of Nephrology 2015.
Cheung K.F., Yung S.S.Y., Yim A.S.Y., Chau K.M., Yap Y.H.D. and Chan D.T.M., Annexin II-binding IgG and IgM in sera of patients with lupus nephritis, 3rd International Conference on Immune Tolerance 2014.
Chu J.Y.S., Yung S.S.Y., Chau K.M., Kam K.M. and Chan D.T.M., MicroRNA-200c inhibits TGF-β1-induced epithelial-to-mesenchymal transition and fibrogenesis in mesothelial cells, Gordon Research Conference - Fibronectin, Integrins & Related Molecules. 2015.
JIANG N., Yung S.S.Y., Chau K.M., Zhang Q. and Chan D.T.M., Decorin Suppresses Mesothelial Cell Epithelial-to-Mesenchymal Transition, 15th Congress of the International Society for Peritoneal Dialysis. 2014.
LI N., Chau K.M., Kam K.M., Chan D.T.M. and Yung S.S.Y., Peritonitis Induces Native and EDA+ Fibronectin Expression in Peritoneal Mesothelial Cells Via TGF-beta1 and PI3K and MAPK Activation, Gordon Research Conference Fibronectin, Integrins & Related Molecules. 2015.
Tsun J.G.S., Yung S.S.Y., Chau K.M., Shiu S.W.M., Chan D.T.M. and Tan K.C.B., Cellular cholesterol transport proteins in diabetic nephropathy, PLoS One. 2014, 9(9): e105787.
Yung S.S.Y., Ng C.Y., Ho S.K., Cheung K.F., Chan K.W., Zhang Q., Chau K.M. and Chan D.T.M., Anti-dsDNA antibody induces soluble fibronectin secretion by proximal renal tubular epithelial cells and downstream increase of TGF-β1 and collagen synthesis, Journal of Autoimmunity. 2015, 58: 111-122.
Yung S.S.Y., JIANG N., Chau K.M., Zhang Q. and Chan D.T.M., Decorin Ameliorates Peritoneal Fibrosis in Peritoneal Dialysis Related Peritonitis, American Society of Nephrology Kidney Week 2014.
Yung S.S.Y., Tse W.W., Chau K.M. and Chan D.T.M., Inhibition of Hyaluronan Synthesis in NZBWF1/J Mice Decreased Glomerular Deposition of Fibronectin and Collagen and Improved Renal Function, Gordon Research Conference Fibronectin, Integrins & Related Molecules. 2015.


Researcher : Chen JY
Project Title:The development of the common core course "From Health to Wellbeing"
Investigator(s):Chen JY, Chin WY
Department:Family Med & Primary Care
Source(s) of Funding:Teaching Development Grants
Start Date:01/2010


Project Title:Mind-body-spirit integrative training for stress management and prevention against junior physicians’ burnout
Investigator(s):Chen JY, Wong PY
Department:Family Med & Primary Care
Source(s) of Funding:Development Fund for Medical Humanities
Start Date:09/2010


Project Title:Exploration of suffering and wellbeing through visual narratives of illness AND What makes for a better doctor and good medical practice? – Perspectives from Film and Book Narratives
Investigator(s):Chen JY, Chan LC, Chan LK, Tsang JWH, Lam CLK, Fielding R, Chua SE, Leung PPY
Department:Family Med & Primary Care
Source(s) of Funding:Development Fund for Medical Humanities
Start Date:10/2010


Project Title:Developing resilience and enhancing wellbeing in medical students through a structured self-awareness programme The Art of Empathy: Using the Arts to Cultivate Empathy for Patients and Develop Self-awareness
Investigator(s):Chen JY, Chan LC, Potash JS
Department:Family Med & Primary Care
Source(s) of Funding:Development Fund for Medical Humanities
Start Date:10/2011


Project Title:Development, implementation and preliminary evaluation of a longitudinal programme for early student experiential learning of professionalism
Investigator(s):Chen JY, Chin WY, Fung SCC
Department:Family Med & Primary Care
Source(s) of Funding:Teaching Development Grants
Start Date:08/2012


Project Title:An exploratory qualitative study of the illness experience of end stage renal disease patients in Hong Kong undergoing hemodialysis in the hospital or in the community
Investigator(s):Chen JY, Wong W, Tang SCW
Department:Family Med & Primary Care
Source(s) of Funding:Small Project Funding
Start Date:06/2013


Project Title:Evaluating the impact and feasibility of a cross-disciplinary, library-based mindful practice programme for healthcare and human service students
Investigator(s):Chen JY, Wong PY, Chan LC, Ho RTH, Wong RSC
Department:Family Med & Primary Care
Source(s) of Funding:Teaching Development Grants
Start Date:11/2013


Project Title:The psychometric properties of the Kidney Disease and Quality of Life–36 (KDQOL-36) in Chinese patients with end-stage renal disease (ESRD)
Investigator(s):Chen JY, Choi PH, Lam CLK, Wan YF, Lo WK, Lui SL
Department:Family Med & Primary Care
Source(s) of Funding:Small Project Funding
Start Date:01/2015


Project Title:Towards altruism and social responsibility in Hong Kong: piloting and exploring the feasibility of a service learning programme
Investigator(s):Chen JY, Yu YTE, Wong WCW, Johnston JM, Beh SL
Department:Family Med & Primary Care
Source(s) of Funding:Development Fund for Medical Humanities
Start Date:01/2015


Project Title:Assessing student support needs to inform the teaching and learning of undergraduate medicine and health sciences
Investigator(s):Chen JY, Chin WY, Chan LK, Tiwari AFY, Sham MH, Feng Y
Department:Family Med & Primary Care
Source(s) of Funding:Teaching Development Grants
Start Date:06/2015


Project Title:13th International Conference on Communication, Medicine and Ethics (COMET); The illness experience of end stage renal disease patients in Hong Kong undergoing hemodialysis
Investigator(s):Chen JY
Department:Family Med & Primary Care
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2015


List of Research Outputs

Wu S.M., Chu T.K., Chan M.L., Liang J., Chen J.Y. and Wong S.Y.S., A study on what influences undergraduates to choose family medicine as a career., Hong Kong Practitioner. 2014, 36: 123-131.


Researcher : Chen WH
Project Title:Enoxaparin combined with epitfibatide or abciximab versus unfractionated heparin combined with epitfibatide or abciximab in percutaneous coronary intervention: obersvations on efficacy, safety, anticoagulation profile, and level of platelet inhibition
Investigator(s):Chen WH, Lau CP
Department:Medicine
Source(s) of Funding:Other Funding Scheme
Start Date:06/2001


Project Title:A prospective study to investigate the determinants of the quantity of embolized debris during native vessel percutaneous coronary intervention
Investigator(s):Chen WH, Lau CP
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2002


Project Title:A prospective study to evaluate the relation between aspirin resistance and the incidence and magnitude of myonecrosis after percutaneous coronary intervention
Investigator(s):Chen WH, Lau CP
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2003




Researcher : Cheng CTK
List of Research Outputs

Lai C.L., Wong D.K.H., Ip P.C.P., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lee B.P., Cullaro G., Wu C.H., Cheng C.T.K., Yuen J.C.H., Ngai W.S. and Yuen R.M.F., Profound Reduction of HBV Covalently Closed Circular DNA with Long-term Nucleoside/tide Analogue Therapy, Hepatology. 2014, 60, No. 4 (Suppl): 183A.


Researcher : Cheng CW
Project Title:Role of PIN1 in the promotion of DNA double-strand break repair through interaction with ATM protein
Investigator(s):Cheng CW, Tse EWC
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:12/2014


List of Research Outputs

Tse H.F., Turner S., Sanders P., Okuyama Y., Fujiu K., Cheng C.W., Russo M., Green M.D., Yiu K.H., Chen P., Shunto C., Lau E.O. and Siu D.C.W., Thoracic Spinal Cord Stimulation for Heart Failure as a Restorative Treatment (SCS HEART study): first-in-man experience, Heart Rhythm. 2015, 12(3): 588-595.


Researcher : Cheng KY
Project Title:The role of APPL2 in the regulation of insulin secretion and glucose homeostasis in mice
Investigator(s):Cheng KY, Xu A
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2013


Project Title:The role of hypothalamic APPL2 in energy metabolism
Investigator(s):Cheng KY, Xu A
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2014


Project Title:The adaptor protein APPL2 as a physiological modulator of pancreatic β-cell functions in mice
Investigator(s):Cheng KY, Cheung YY
Department:Medicine
Source(s) of Funding:National Natural Science Foundation of China (NSFC) - General Program
Start Date:01/2015


Project Title:The MDM2-p53 pathway as a novel regulator of glucose-stimulated insulin secretion in pancreatic beta cells
Investigator(s):Cheng KY, Xu A
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2015


Project Title:Hypothalamic APPL2 combats against obesity by promoting adaptive thermogenesis in adipose tissues
Investigator(s):Cheng KY, Xu A
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2015


Project Title:APPL2 as a key mediator of white-to-beige fat transdifferentiation
Investigator(s):Cheng KY, Xu A
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2015


List of Research Outputs

CHEN Z., Cheng K.Y. and Xu A., Adaptor protein APPL1 counteracts streptozotocin-induced diabetes in mice., Diabetes Congress 2015.
Cheng K.Y., New insights on the regulation of insulin secretion., The 10th International Symposium on Healthy Aging 2015. A Decade of Positive Aging. 2015.. 2015.
Cheng K.Y., The adaptor proteins APPL1 and APPL2 as key regulators of insulin action and secretion., The 2nd Hong Kong International Symposium on Metabolic Medicine. From Bench to Bedsides. 2014.. 2014.
KWOK H.M., Cheng K.Y., Li F.Y.L., Chan Y.C.C., Hoo R.L.C., Ye D., Xu A. and Lam K.S.L., Inactivation of c-Jun N-terminal Kinase in Adipose Tissue Alleviates Atherosclerosis in Diet-induced Obese ApoE-deficient Mice, 83rd European Atherosclerosis Society Congress. 2015.
Ng C.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Lam K.S.L., Xu A. and Chan K.H., Adiponectin deficiency induced cognitive dysfunction and Alzheimer’s disease pathogenesis in mice through the disruption of insulin sensitivity and inactivated AMPK signaling , 67th American Academy of Neurology Annual Meeting. 2015.
Ng C.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Lam K.S.L., Xu A. and Chan K.H., Research Travel Scholarship 2015, American Academy of Neruology. 2015.
WANG B., Cheng K.Y., Li X., Lam K.S.L. and Xu A., Hypothalamic APPL2 combats against obesity by promoting adaptive thermogenesis in white adipose tissues, EMBL Symposium: Translating Diabetes.. 2015.
WANG B., Cheng K.Y., Li X., Li A., Lam K.S.L. and Xu A., The Role of Hypothalamic APPL2 in Regulation of Energy Expenditure in Adipose Tissues, 2015 Asia Pacific obesity and diabetes symposium.. 2015.
WANG B., Cheng K.Y., Li X., Li A., Lam K.S.L. and Xu A., The hypothalamic APPL2 as a novel regulator of energy homeostasis in adipose tissues, The 10th International Symposium on Healthy Aging 2015. A Decade of Positive Aging. 2015.. 2015.


Researcher : Cheng OY
List of Research Outputs

Ng C.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Lam K.S.L., Xu A. and Chan K.H., Adiponectin deficiency induced cognitive dysfunction and Alzheimer’s disease pathogenesis in mice through the disruption of insulin sensitivity and inactivated AMPK signaling , 67th American Academy of Neurology Annual Meeting. 2015.
Ng C.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Lam K.S.L., Xu A. and Chan K.H., Research Travel Scholarship 2015, American Academy of Neruology. 2015.


Researcher : Cheng YY
Project Title:The role of hypoxia inducible factor 1 alpha in NK/T-cell lymphoma
Investigator(s):Cheng YY, Tse EWC
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:12/2008




Researcher : Cheung BMY
Project Title:Does an elevated lipocalin-2 concentration in plasma lead to endothelial dysfunction and hypertension?
Investigator(s):Cheung BMY, Lam KSL, Tse HF, Wang Y
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2012


Project Title:Accelerating the Development of Pharmacogenomics at HKU through a Systems Biology Approach
Investigator(s):Cheung BMY
Department:Medicine
Source(s) of Funding:Innovative Research Grants
Start Date:07/2013


Project Title:Beta-2 Microglobulin as a Biomarker in Acute Coronary Syndrome
Investigator(s):Cheung BMY, Cheung CL
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2014


Project Title:The 2015 Ageing Summit; Longevity and beta-2 microglobulin
Investigator(s):Cheung BMY
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:02/2015
Completion Date:02/2015


Project Title:The pharmacoepidemiology of serious adverse drug reactions due to colchicine in Hong Kong
Investigator(s):Cheung BMY, Cheung CL, Wong ICK, Lam MPS, Hung IFN, Cheung TT
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2015


List of Research Outputs

Chan Y.H., Lau K.K., Yiu K.H., Li L.S.W., Tam S., Lam T.H., Lau C.P., Siu D.C.W., Cheung B.M.Y. and Tse H.F., Vascular protective effects of statin-related increase in serum 25-hydroxyvitamin D among high-risk cardiac patients, Journal of Cardiovascular Medicine. 2015, 16: 51-58.
Chan Y.H., Lau G.K.K., Yiu K.H., Li L.S.W., Tam S., Lam T.H., Lau C.P., Siu D.C.W., Cheung B.M.Y. and Tse H.F., Vascular protective effects of statin-related increase in serum 25-hydroxyvitamin D among high-risk cardiac patients, Journal of Cardiovascular Medicine (Hagerstown). 2015.
Cheung A.J. and Cheung B.M.Y., False detection of atrial fibrillation in children by a blood pressure monitor with atrial fibrillation detection function, BMJ Case Reports. 2015, 2015: bcr2014207974-bcr2014207974.
Cheung B.M.Y., Board of International Consulting Editors, Elsevier, Health & Medical Sciences. 2015.
Cheung B.M.Y., Chairman, Subcommittee in Clinical Pharmacology & Therapeutics, Hong Kong College of Physicians. 2015.
Cheung B.M.Y., Member, Editorial Board , Annals of Translational Medicine. 2015.
Cheung B.M.Y., Member, HKU/HA HKW IRB. 2015.
Cheung B.M.Y., National medical Research Council International Expert Panel, National Medical Research Council. 2014.
Cheung B.M.Y., The 2015 Ageing Submit, Longevity and beta-2 microglobulin. 2015.
Cheung C.L., Lam K.S.L., Wong I.C.K. and Cheung B.M.Y., Non-invasive score identifies ultrasonography-diagnosed non-alcoholic fatty liver disease and predicts mortality in the USA, BMC Medicine. 2014, 12: 154.
Cheung T.T., TSOI M.F. and Cheung B.M.Y., Effect of TNF inhibitors on subclinical atherosclerosis in patients with rheumatoid arthritis: a meta-analysis, Annual European Congress of Rheumatology 2015.
Cheung T.T., TSOI M.F. and Cheung B.M.Y., Inorganic mercury poisoning due to the use of beauty cream in Hong Kong , 12th Congress of the European Association for Clinical Pharmacology and Therapeutics. 2015.
Cheung T.T., Cheung C.L., Tan K.C.B., Leung Y.H. and Cheung B.M.Y., People With Peripheral Arterial Disease And Diabetes Are Associated With Clinically Significant Weakness , International conference on diabetes and metabolism. 2014.
Cheung Y.Y., Hui Y.L.E., Cheung B.M.Y., Woo Y.C., Xu A., Fong H.Y., Ong K.L., Yeung C.Y., Janus E.D., Tse H.F., Sham P.C. and Lam K.S.L., Adiponectin gene variants and the risk of coronary heart disease: a 16-year longitudinal study., Eur J Endocrinol. 2014, 171: 107-115.
Hui Y.L.E., Xu A., Chow W.S., Lee P.C.H., Fong H.Y., Cheung C.W.S., Tse H.F., Chau M.T., Cheung B.M.Y. and Lam K.S.L., Hypoadiponectinemia As an Independent Predictor for the Progression of Carotid Atherosclerosis: A 5-Year Prospective Study, Metabolic Syndrome and Related Disorders. 2014, 12: 517-522.
Kumana C.R., Cheung B.M.Y. and Chan L.S., Airport screening for Ebola: current thermal scanning procedures are unreliable, BMJ. 2014, 349: g6571-g6571.
ONG K.L., McClelland R.L., Rye K.A., Cheung B.M.Y., Post W.S., Vaidya D., Criqui M.H. and Cushman M., The relationship between insulin resistance and vascular calcification in coronary arteries, and the thoracic and abdominal aorta: The Multi-Ethnic Study of Atherosclerosis., Atherosclerosis. 2014, 236(2): 257-262.
Ong K.L., Ding J.Z., McClelland R.L., Cheung B.M.Y., Criqui M.H., Barter P.J., Rye K.A. and Allison M.A., Relationship of pericardial fat with biomarkers of inflammation and hemostasis, and cardiovascular disease: The Multi-Ethnic Study of Atherosclerosis, Atherosclerosis. 2015, 239: 386-392.
SAMARANAYAKE N.R., Cheung D.S., LAM P.S.M., Cheung T.T., Chui W.C., Wong I.C. and Cheung B.M.Y., The effectiveness of a 'Do Not Use' list and perceptions of healthcare professionals on error-prone abbreviations. Epub ahead of print, Int J Clin Pharm. 2014.
SING C.W., Cheung C.L., Lam K.S.L. and Cheung B.M.Y., Low lean mass and gait speed in people with both diabetes and peripheral arterial disease, Tenth International Symposium on Healthy Aging, " A Decade of Positive Aging" March 7-8, 2015, Hong Kong. 2015.
SING C.W., Cheung C.L., Wong I.C.K., Cheung B.M.Y., Yeung C.K., Chan H.H.L. and Chan C.Y.J., Toxic Epidermal Necrolysis: Clinical profile, aetiology and treatment in a tertiary hospital over a 16-year period. , Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and the British Pharmacological Society (BPS) Joint Scientific Meeting. 2015.
SING C.W., Cheung C.L., Cheung B.M.Y., Wong I.C.K. and Chan C.Y.J., Toxic epidermal necrolysis: clinical profile in a tertiary hospital over a 15-year period, 19th Research Postgraduate Symposium, December 11, 2014, Hong Kong. 2014.
Samartzis D., Bow H.Y.C., Karppinen J.I., Luk K.D.K., Cheung B.M.Y. and Cheung K.M.C., Family history of low back pain is a significant predictor of pain and disability between extreme stages of lumbar disc degeneration, 34th Annual Meeting of the Hong Kong Orthopaedic Association. Hong Kong, 2014.
Samartzis D., Bow H.Y.C., Karppinen J.I., Luk K.D.K., Cheung B.M.Y. and Cheung K.M.C., Hypertension is independently associated with lumbar disc degeneration: a large-scale population-based study, 34th Annual Meeting of the Hong Kong Orthopaedic Association. Hong Kong, 2014.
Sing C.W., Lui V.W.Y., Sham P.C., Tan K.C.B., Kung A.W.C., Wong I.C.K., Cheung B.M.Y., Chan J.C.Y. and Cheung C.L., JAG1 Polymorphism is Associated with Incident Neoplasm., 23rd Annual International Genetic Epidemiology Society, Vienna, Aug 2014.
Woo Y.C., Cheung B.M.Y., Yeung C.Y., Lee C.H.P., Hui Y.L.E., Fong H.Y., Tso A.W.K., Tam S. and Lam K.S.L., Cardiometabolic risk profile of participants with prediabetes diagnosed by HbA1c criteria in an urban Hong Kong Chinese population over 40 years of age , Diabetic Medicine. 2015, n/a-n/a.


Researcher : Cheung CL
Project Title:Identification of susceptibility locus of Stevens-Johnson Syndrome and Toxic Epidermal Necrosis in Hong Kong Chinese
Investigator(s):Cheung CL, Cheung BMY, Wong ICK, Sham PC, Chan CYJ
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2013


Project Title:Epidemiological study of serious adverse drug reactions in Hong Kong
Investigator(s):Cheung CL
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2014


Project Title:Genetics and genomics of anti-thyroid drug induced agranulocytosis
Investigator(s):Cheung CL, Kung AWC, Tan KCB, Sham PC, Wong ICK
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2015


Project Title:The role of Vitamin D and bone metabolism in cardiovascular events risk, an interaction or mediation? An 11 year follow-up study
Investigator(s):Cheung CL, Tan KCB, Kung AWC, Cheung BMY
Department:Pharmacology & Pharmacy
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:02/2015


List of Research Outputs

Cheung C.L., APSAVD-EMW Young Investigator Oral Award – Winner, 9th Congress of the Asian Pacific Society of Atherosclerosis and Vascular Diseases and 16th Diabetes and Cardiovascular Risk Factors – East Meets West Symposium, Hong Kong. 2014.
Cheung C.L., Best Poster Award , 9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress, Kyoto, Japan. 2014.
Cheung C.L., Lam K.S.L., Wong I.C.K. and Cheung B.M.Y., Non-invasive score identifies ultrasonography-diagnosed non-alcoholic fatty liver disease and predicts mortality in the USA, BMC Medicine. 2014, 12: 154.
Kwan S.H., Hsu Y.H., Cheung C.L., Dupuis J., Saint-Pierre A., Eriksson J., Handelman S.K., Aragaki A., Karasik D., Pramstaller P.P., Kooperberg C., Lacroix A.Z., Larson M.G., Lau K.S., Lorentzon M., Pichler I., Sham P.C., Taliun D., Vandenput L. and Kiel D.P., Meta-analysis Of Genome-wide Association Studies Identifies Two Loci Associated With Circulating Osteoprotegerin Levels., Hum Mol Genet. 2014.
SING C.W., Cheung C.L., Wong I.C.K., Cheung B.M.Y., Yeung C.K., Chan H.H.L. and Chan C.Y.J., Toxic Epidermal Necrolysis: Clinical profile, aetiology and treatment in a tertiary hospital over a 16-year period. , Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and the British Pharmacological Society (BPS) Joint Scientific Meeting. 2015.


Researcher : Cheung KF
Project Title:Serum levels and intra-renal expression of annexin II in patients and mice with lupus nephritis, and their correlation with disease activity
Investigator(s):Cheung KF, Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:06/2014


Project Title:3rd International Conference on Immune Tolerance 2014; Annexin II-binding IgG and IgM in sera of patients with lupus nephritis
Investigator(s):Cheung KF
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:09/2014
Completion Date:09/2014


List of Research Outputs

Cheung K.F., Yung S.S.Y., Yim A.S.Y., Chau K.M., Yap Y.H.D. and Chan D.T.M., Annexin II-binding IgG and IgM in sera of patients with lupus nephritis, 3rd International Conference on Immune Tolerance 2014.
Yung S.S.Y., Ng C.Y., Ho S.K., Cheung K.F., Chan K.W., Zhang Q., Chau K.M. and Chan D.T.M., Anti-dsDNA antibody induces soluble fibronectin secretion by proximal renal tubular epithelial cells and downstream increase of TGF-β1 and collagen synthesis, Journal of Autoimmunity. 2015, 58: 111-122.


Researcher : Cheung RTF
Project Title:Role of ischemia in Alzheimer's disease - an experimental study in transgenic mice
Investigator(s):Cheung RTF
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2004


Project Title:Development of Chinese-language versions of internationally-accepted stroke training materials for healthcare professionals treating Chinese stroke patients
Investigator(s):Cheung RTF
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:04/2005


Project Title:Neuroprotective effects of melatonin and/or electro-acupuncture (EA) on focal cerebral ischemia in rats
Investigator(s):Cheung RTF
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2009


Project Title:A pilot study of silent brain infarcts in healthy hypertensive elderly Chinese: the first 100 subjects
Investigator(s):Cheung RTF
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:05/2012
Completion Date:04/2015


Project Title:Adverse effects of up-regulated adiponectin level on immune system in mice stroke models. Part I: effects of exogenous PPARgamma antagonist (BADGE) in wide type and transgenic mice.
Investigator(s):Cheung RTF
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:03/2013


Project Title:Neuroprotection of melatonin and calpeptin in a rat ischemic stroke model
Investigator(s):Cheung RTF
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:05/2014


List of Research Outputs

CHENG K.Y., Chan K.M.K., CHIU M.Y., Wong C.S., Li L.S.W. and Cheung R.T.F., Effects of repetitive transcranial magnetic stimulation on post-stroke survivors' swallowing functions, 2nd Australasian and Asia Pacific Laryngology Conference 2014.
CHENG K.Y., Chan K.M.K., Wong C.S. and Cheung R.T.F., Preliminary evidence of the effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) on swallowing functions in post-stroke individuals with chronic dysphagia, International Journal of Language & Communication Disorders. 2015, 50: 389-396.
Cheung R.T.F., A systematic approach to the definition of stroke, Austin Journal of Cerebrovascular Disease & Stroke. 2014, 1: 5-9.
Cheung R.T.F., Associate Editor, Advances in Alzheimer's Disease. Scientific Research Publishing, 2015.
Cheung R.T.F., Chronic Neurological Diseases, Phase Two: Chronic Diseases, Certificate Course of Primary Healthcare for Traditional Chinese Medicine Practitioners, Hong Kong Association of Integration of Chinese-Western Medicine. 2014.
Cheung R.T.F., Editorial Board, Asian Journal of Neuroscience. Hindawi Publishing, 2015.
Cheung R.T.F., Editorial Board, Austin Journal of Anatomy. Austin Publishing Group, 2014.
Cheung R.T.F., Editorial Board, Austin Journal of Cerebrovascular Disease & Stroke. Austin Publishing Group, 2015.
Cheung R.T.F., Editorial Board, Chinese Journal of Neurology. Chinese Medical Association, 2015.
Cheung R.T.F., Editorial Board, Chinese version of Stroke. 2015.
Cheung R.T.F., Editorial Board, Edorium Journal of Neurology. Edorium Journal, 2015.
Cheung R.T.F., Editorial Board, JSM Ophthalmology. JSciMedCentral, 2015.
Cheung R.T.F., Editorial Board, Journal of Pineal Research. Blackwell Publishing, 2015.
Cheung R.T.F., Editorial Board, Medical Progress. CMPMedica, 2014.
Cheung R.T.F., Editorial Board, Reviews on Recent Clinical Trials. Bentham Science Publishers, 2015.
Cheung R.T.F., Editorial Board, Stroke Research and Treatment. Hindawi Publishing Corporation, 2015.
Cheung R.T.F., Editorial Board, The Open Medical Imaging Journal. Bentham Science Publishers, 2015.
Cheung R.T.F., Editorial Board, The Open Neuroimaging Journal. Bentham Science Publishers, 2015.
Cheung R.T.F., Editorial Board, The Open Nuclear Medicine Journal. Bentham Science Publishers, 2015.
Cheung R.T.F., Editorial Board, The Open Physiology Journal. Bentham Science Publishers, 2015.
Cheung R.T.F., Editorial Board, World Journal of Biological Chemistry. Baishideng Publishing Group, 2015.
Cheung R.T.F., Journal editor, SM Journal of Neurology and Neuroscience. 2015.
Cheung R.T.F., Regional Editor, Cardiovascular & Hematological Agents in Medicinal Chemistry. Bentham Science Publishers, 2014.
Cheung R.T.F., Session Chairperson for Symposium B: Risk factors & new therapeutic approaches in Alzheimer’s Disease, The International Alzheimer’s Disease Conference 2015 on “Early Detection, Treatment & Prevention of Dementia: Patients’ and Caregivers’ Perspectives”, 26-27 June 2015, Cheung Kung Hai Lecture Theatres, LKS Faculty of Medicine, HKU, Hong Kong. 2015.
Fan J., Cheung R.T.F., Chu L.W., Fung P.C.W., Chang C.Q., Sik H.H., ZHANG M., XIE B. and Gao J., Reduced bilateral temporal Alpha-band EEG activity during resting state in older adults, International Conference on Digital Signal Processing. Hong Kong, 2014.
GAO Y., Cheung R.T.F., Gao J., Lau E.Y.Y., WAN H.Y. and Mok T.M.Y., Evaluation of cognitive function by electrophysiological study in systemic lupus erythematosus patients with previous neuropsychiatric involvement. European League of Association of Rheumatology (EULAR) 2015, Ann Rheum Dis 2015; 74(Suppl2), 2015, 74(Suppl2): 1099.
Gao J., Fan J., Cheung R.T.F., Sik H.H., Huang B.S., Zhang Z.G., Hung Y.S. and Chang C.Q., Decreased Chaotic Electroencephalograph (EEG) Signal During Mindfulness-Based Stress Reduction (MBSR) Meditation, International Symposium for Contemplative Studies. Boston, 2014.
Kwan S.K.J., Chu L.W., Chan H.W.F., Lee T.M.C., Law A.C.K., Mak H.K.F., Cheung R.T.F., Chang R.C.C., Lum T.Y.S. and Tang S.C.W., Comparing vascular dementia and Alzheimer’s dementia: a preliminary, cross-sectional, multimodal comparative study evaluating clinical and cognitive profile, neuroimaging, biomarkers and quantitative EEG ($240,000), Seed Funding HKU. 2014.
Lau G.K.K., Chan L.K., Li O.Y., Yuen T.K., Wong Y.K., Chan K.H., Chan J.F.W., Chang S.K.R., Cheung R.T.F., Doherty I., Ho S.L., Hon F.K.S., Kwan S.K.J., Lee R., Leung G.K.K., Mak W., Mak H.K.F., Shih K.C. and Tsang C.O.A., Establishing an eLearning Platform in Clinical Neurosciences, East-West Alliance Global Symposia 2014.
Lau G.K.K., Chan L.K., Chan K.H., Chang S.K.R., Chang R.C.C., Cheung R.T.F., Doherty I., Ho S.L., Hon S.F.K., Kwan S.K.J., Lee R., Leung G.K.K., Mak W., Shih K.C. and Tsang C.O.A., ePoster Award (First Prize), Title: Establishing an eLearning Platform in Clinical Neurosciences at HKU, HKU Li Ka Shing Faculty of Medicine Frontiers Series – East-West Alliance Global Symposia. 2014.
Lee J.C., Pang S.Y., Lam C.L.D., Tse A.C., Lau G.K.K., Chang S.K.R., Ho S.L., Cheung R.T.F., Mak W., Hon F.K.S., Chang C.K., Teo K.L. and Chan K.H., Myasthenic crisis in patients with generalised myasthenia gravis. Hong Kong Academy of Medicine, 2014., 2015.
Sang L.Y.H., Yang X.Y., Su H.X., Leung G.K.K., Wu W. and Cheung R.T.F., Local delivery of neural progenitor cells and nanomaterial improves functional outcome in a rat model of intracerebral hemorrhage, The European Stroke Organization Conference 2015, Glasgow, U.K., 17-19 April 2015.
Sang L.Y.H., Yang X., Su H.X., Leung G.K.K., Wu W. and Cheung R.T.F., Replacement of hematoma with neural progenitor cells embedded in a nanomaterial in a rat model of intracerebral hemorrhage, The 21st Annual Scientific Meeting of the Hong Kong Neurosurgical Society, Hong Kong, 5-6 December 2014.
ZHANG L., Cheung R.T.F., Chu L.W. and Mak H.K.F., Structural MRI measures in Alzheimer’s disease and effects of ethnicity. , Alzheimer’s Association International Conference.. 2014.
ZHANG M., XIE B., Mak H.K.F. and Cheung R.T.F., Cognitive impairments in patients with severe periventricular hyperintensities, Twentieth Medical Research Conference, Department of Medicine, The University of Hong Kong. 2015, 21 (Suppl 1): 59.


Researcher : Cheung TT
Project Title:Cost of illness of Ankylosing Spondylitis in Hong Kong
Investigator(s):Cheung TT, Lau WCS, Cheung BMY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2014


Project Title:Correlation of Fibroblast Growth Factor 21 (FGF21) with paracetamol levels in patients with paracetamol poisoning
Investigator(s):Cheung TT, Cheung BMY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2015


List of Research Outputs

Cheung T.T., TSOI M.F. and Cheung B.M.Y., Effect of TNF inhibitors on subclinical atherosclerosis in patients with rheumatoid arthritis: a meta-analysis, Annual European Congress of Rheumatology 2015.
Cheung T.T., TSOI M.F. and Cheung B.M.Y., Inorganic mercury poisoning due to the use of beauty cream in Hong Kong , 12th Congress of the European Association for Clinical Pharmacology and Therapeutics. 2015.
Cheung T.T., Cheung C.L., Tan K.C.B., Leung Y.H. and Cheung B.M.Y., People With Peripheral Arterial Disease And Diabetes Are Associated With Clinically Significant Weakness , International conference on diabetes and metabolism. 2014.
SAMARANAYAKE N.R., Cheung D.S., LAM P.S.M., Cheung T.T., Chui W.C., Wong I.C. and Cheung B.M.Y., The effectiveness of a 'Do Not Use' list and perceptions of healthcare professionals on error-prone abbreviations. Epub ahead of print, Int J Clin Pharm. 2014.


Researcher : Cheung YY
Project Title:Impact of newly identified type 2 diabetes susceptibility loci on the risk of coronary artery disease among patients with T2DM.
Investigator(s):Cheung YY, Lam KSL
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:06/2013
Completion Date:11/2014


Project Title:10th International Diabetes Federation-Western Pacific Region (IDF-WPR) Congress 2014; Impact of diabetic retinopathy genetic variants identified on genome-wide association studies on microvascular complications in Chinese patients with type 2 diabetes
Investigator(s):Cheung YY
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:11/2014
Completion Date:11/2014


Project Title:Causal effect of adiposity in diabetic retinopathy: a Mendelian randomisation analysis
Investigator(s):Cheung YY, Lam KSL
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:03/2015


List of Research Outputs

Cheung Y.Y., Hui Y.L.E., Cheung B.M.Y., Woo Y.C., Xu A., Fong H.Y., Ong K.L., Yeung C.Y., Janus E.D., Tse H.F., Sham P.C. and Lam K.S.L., Adiponectin gene variants and the risk of coronary heart disease: a 16-year longitudinal study., Eur J Endocrinol. 2014, 171: 107-115.


Researcher : Chim JCS
Project Title:FISH study and the use of bortezomib in high-risk multiple myeloma
Investigator(s):Chim JCS
Department:Medicine
Source(s) of Funding:Lee Hysan Foundation - General Award
Start Date:07/2008


Project Title:Study of methylation of microRNA in mantle cell lymphoma
Investigator(s):Chim JCS
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2012


Project Title:Genetic study (FISH study) for personalized treatment of multiple myeloma
Investigator(s):Chim JCS
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:11/2012


Project Title:Epigenetic silencing of tumour suppressor miR-212/132 cluster in Philadelphia-negative myeloproliferative neoplasm
Investigator(s):Chim JCS
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2013


Project Title:Use of Bortezomib during conditioning of autologous stem cell transplantation of international stage III myeloma
Investigator(s):Chim JCS, Kwong YL, Lie AKW
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:03/2014


Project Title:Epigenetic silencing of MIR-340 in haematological malignancies
Investigator(s):Chim JCS
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2014


Project Title:Mechanism study of the effect of microenviroment on RANKL expression in myeloma cells
Investigator(s):Chim JCS, Wong KY
Department:Medicine
Source(s) of Funding:National Natural Science Foundation of China (NSFC) - General Program
Start Date:01/2015


List of Research Outputs

Chim J.C.S., American Journal of Molecular Biology, 2014.
Chim J.C.S., American Journal of Translational Research, 2015.
Chim J.C.S., Austin Biomarkers & Diagnosis, 2014.
Chim J.C.S., Blood Cancer Journal (http://www.nature.com/bcj/about/index.html#Editors) , 2015.
Chim J.C.S., Bone Marrow Transplantation (impact factor :3.6) , 2015.
Chim J.C.S. and Wong K.Y., Bortezomib/bendamustine/dexamethasone induced good partial response in refractory relapse post-ASCT with constitutive RAS activation due to V600E BRAF mutation, Bone Marrow Transplantation. 2014, in press.
Chim J.C.S., Cancer Reports (BioMed Best), 2015.
Chim J.C.S., Carcinogenesis (impact factor :5.4) , 2015.
Chim J.C.S., Case Reports in Oncological Medicine . 2014.
Chim J.C.S., Chinese Medical Journal. 2014.
Chim J.C.S., Clinical Epigenetics, 2014.
Chim J.C.S., Current Advances in Chemistry Research (CACR). 2014.
Chim J.C.S., DNA methylation of tumor suppressive microRNA in myeloma, 5th Clinical Epigenetics International Meeting (CLEPSO 2015), Düsseldorf, Germany. 2015.
Chim J.C.S., Editor-in-Chief, Journal of Genetics Study . 2014.
Chim J.C.S., Epigenomics (impact factor:3.429), 2014.
Chim J.C.S., Frontiers in Biological Chemistry . 2014.
Chim J.C.S., Frontiers in Epigenomics, 2014.
Chim J.C.S., Global Journal of Hematology and Blood Transfusion. 2015.
Chim J.C.S., Health (http://www.scirp.org/journal/health), 2014.
Chim J.C.S., Hematology and Leukemia (Herbert Open Access Journals), 2015.
Chim J.C.S., Immunotherapy of multiple myeloma, XXXV World Congress International Society of Hematology (ISH), Beijing, China. 2014.
Chim J.C.S., International Journal of Advanced Chemistry Research (IJACR) . 2014.
Chim J.C.S., International Journal of Cancer Immunology & Immunotherapy. 2014.
Chim J.C.S., International Journal of Health . 2015.
Chim J.C.S., International Journal of Hematology Research (IJHR). 2014.
Chim J.C.S., International Journal of Oncology (impact factor: 2.57) , 2015.
Chim J.C.S., Journal of Applied Scientific Reports . 2014.
Chim J.C.S., Journal of Cancer Metastasis and Treatment, 2014.
Chim J.C.S., Journal of Genetics Study, 2015.
Chim J.C.S., Journal of Hematology Oncology (IF: 3.99), 2015.
Chim J.C.S., Journal of Hematology, Blood Transfusion and Disorders (HBTD. 2015.
Chim J.C.S., Journal of Life Medicine, 2015.
Chim J.C.S., Journal of Transplantation Technology, 2015.
Chim J.C.S., Journal of cancer studies and therapy, 2014.
Chim J.C.S., Sim P.Y.J., Tam S., Tse E.W.C., Lie A.K.W. and Kwong Y.L., LDH is an adverse prognostic factor independent of ISS in transplant-eligible myeloma patients receiving bortezomib-based induction regimens, European Journal of Haematology. 2014, n/a-n/a.
Chim J.C.S., Modern Chemotherapy . 2014.
Chim J.C.S., Molecular Biology and Genetic Engineering , 2015.
Chim J.C.S., Non-Coding RNA. 2015.
Chim J.C.S., Optimal Induction regimens in myeloma, The 1st West China International Haematological Malignancy Summit, Chengdu, Sichuan, China. 2015.
Chim J.C.S., Optimal induction in Myeloma: Doublet vs. Triplet, 6th International Hematologic Malignancies Conference: BTG 2015, Beijing, China. 2015.
Chim J.C.S., PLoS ONE (impact factor: 4.41), 2014.
Chim J.C.S., Scientifica, 2015.
Chim J.C.S., Senior Editor, Journal of Gene Therapy . 2014.
Chim J.C.S., The Asia-Pacific Journal of Oncology and Hematology. 2015.
Chim J.C.S., The Hong Kong Medical Diary. 2015.
Chim J.C.S., The Open Access Journal of Science and Technology, 2014.
Chim J.C.S., The Open Leukemia Journal. 2014.
Chim J.C.S., The Open Pathology Journal. 2015.
Chim J.C.S., The Open Surgical Oncology Journal. 2015.
Chim J.C.S., The Open Translational Medicine Journal. 2014.
Chim J.C.S., Translational Oncology (impact factor: 2.40), 2015.
Chim J.C.S., Transplantation Technology . 2015.
Chim J.C.S., Trends in Molecular Biology . 2014.
Chim J.C.S., World Journal of Clinical Oncology. 2015.
Chim J.C.S., 《白血病•淋巴瘤》雜誌 , 2015.
Hwang Y.Y.G., Mohty M. and Chim J.C.S., Allogeneic hematopoietic stem cell transplantation in Philadelphia-negative adult ALL: myeloablative, non-myeloablative and beyond, Hematology. 2014, Epub ahead of print.
Ng H.Y., Wan T.S.K., So J.C.C. and Chim J.C.S., Epigenetic inactivation of DAPK1, p14ARF, mir-34a and -34b/c in acute promyelocytic leukaemia, Journal of Clinical Pathology. 2014, 67: 626-631.
WANG L. and Chim J.C.S., DNA methylation of tumor suppressor miRNAs genes in chronic lymphocytic leukemia, Epigenomics. 2015, 7(3): 461-473.
YIM L.H.R., Wong K.Y., Kwong Y.L., Loong F., Leung C.Y., Chu R., Lam W.W., Hui P.K., Lai R. and Chim J.C.S., Methylation of miR-155-3p in mantle cell and other non-Hodgkin's lymphoma, Oncotarget. 2014, in press.


Researcher : Chiu BCF
List of Research Outputs

Chin W.Y., Lam C.L.K., Wong S.Y.S., Fong D.Y.T., Lo Y.C.Y., Lam T.P., Chiu B.C.F. and Chan T.Y., The Epidemiology and Natural History of Depressive Disorders in Hong Kong's Primary Care, 2014 Health Research Symposium. 2014.


Researcher : Chiu JWY
Project Title:A study of the combination of sirolimus-based immunosuppressant with sorafenib in recurrent hepatocellular carcinoma (HCC) post liver transplant (LT)
Investigator(s):Chiu WYJ, Yau TCC, Cheung TT
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2015


List of Research Outputs

Chiu J.W.Y., Wong H.Y.H., Leung R.C.Y., Pang R.W.C., Cheung T.T., Fan S.T., Poon R.T.P. and Yau T.C.C., Advanced Pancreatic Cancer: Flourishing Novel Approaches in the Era of Biological Therapy, Oncologist. 2014.


Researcher : Chiu KCP
List of Research Outputs

Lau G.K.K., Chiu K.C.P., Shih K.C., Chu L.W., Ho S.L. and Mak W., Miller Fisher syndrome in a Chinese octogenarian presenting with dizziness, Asian Journal of Gerontology & Geriatrics. Hong Kong Academy of Medicine Press, 2014, 9:2: 93–5.


Researcher : Chiu WYJ
Project Title:A study of the combination of sirolimus-based immunosuppressant with sorafenib in recurrent hepatocellular carcinoma (HCC) post liver transplant (LT)
Investigator(s):Chiu WYJ, Yau TCC, Cheung TT
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2015


List of Research Outputs

Chiu W.Y.J., Hotte S.J., Kollmannsberger C.K., Renouf D.J., Cescon D.W., Hedley D., Chow S., Moscow J., Perry M., Diaz-Padilla I., Tan D., Hirte H., McWhirter E., Chen H., Siu L.L. and Bedard P.L., A phase 1b trial of AMG386 and temsirolimus in patients with advanced solid tumor (PJC-008/NCI#9041), 26th EORTC-NCI-AACR Symposium 2014.
Chiu W.Y.J., Leung R.C.Y., Suen T.K.D., Chen T.H.C., Chow C.Y.L., Kwok G., Wong H., Cheung P., Yau T.C.C. and Kwong A., A phase II study of neoadjuvant chemotherapy using combined taxane, anthracycline, and cyclophosphamide in high risk HER2-negative locally advanced breast cancer (Abstract & Oral Presentation), Global Breast Cancer Conference 2015 and the 4th International Breast Cancer Symposium, Jeju Island, Korea, 23-25 April 2015.
Chiu W.Y.J., Leung R.C.Y., Suen T.K.D., Chen T.H.C., Chow C.Y.L., Kwok G., Wong H., Cheung P. and Yau T.C.C., KBCF Scholarship on "A phase II study of neoadjuvant chemotherapy using combined taxane, anthracycline, and cyclophosphamide in high risk HER2-negative locally advanced breast cancer", Global Breast Cancer Conference 2015 and the 4th International Breast Cancer Symposium, Jeju Island, Korea, 23-25 April 2015. 2015.
Chiu W.Y.J., KBCF Scholarship, GBCC 2015 & 4th IBCS. 2015.
Chiu W.Y.J., Serra S., Kamel-Reid S., Zhang T., McNamara M.G., Bedard P.L., Hedley D., Moore M., Dhani N.C., Shek T.W.H., Kwong Y.L., Yau T.C.C., Doherty M. and Knox J.J., Next generation sequencing: profiling gallbladder cancer, Gastrointestinal Cancers Symposium 2015.
Chiu W.Y.J. and Sridhar S.S., Opportunities to improve clinical trial design in urothelial cancer, ICRR Clinical Research and Regulatory Affairs. 2015, 32(2): 64-71.
Chiu W.Y.J., Chan K., Chen E.X., Siu L.L. and Abdul Razak A.R., Pharmacokinetic assessment of dacomitinib in patients with locally advanced head and neck squamous cell carcinoma following administration through a gastrostomy feeding tube, Invest New Drugs. 2015, 33(4): 895-900.
Chiu W.Y.J., Phase 1 Oncology drug trials in Hong Kong, The Tumour Board The Hong Kong Sanatorium & ospital. 2015.
Chiu W.Y.J., Systemic treatment of breast cancer - update from ASCO 2015, Hong Kong Breast Cancer Foundation Dinner Symposium. 2015.
Chiu W.Y.J., Understanding breast cancer - treatment and effect effects of medication, Hong Kong Breast Cancer Foundation Patient Education Session . 2015.
Chiu W.Y.J., Yau T.C.C., Cheung T.T., Chan A.C.Y., Chok K.S.H., Dai W.C., Leung R.C.Y., Chan S.C. and Lo C.M., Use of Sorafenib in recurrent hepatocellular carcinoma (HCC) after liver transplantation, Gastrointestinal Cancers Symposium, American Society of Clinical Oncology, San Francisco, USA, 15-17 January 2015.
Chiu W.Y.J., Yau T.C.C., Cheung T.T., Chan A.C.Y., Chok K.S.H., Dai W.C., Leung R., Chan S.C. and Lo C.M., Use of sorafenib in recurrent hepatocellular carcinoma after liver transplantation, Gastrointestinal Cancers Symposium 2015.


Researcher : Chow CH
List of Research Outputs

Weng J.Z., Kong M.C.W., Ren L., Karakikes I., Geng L., HE J., Chow M.Z.Y., Mok C.F., Keung W.W.Y., Chow C.H., Leung A.Y.H., Hajjar R.J., Li R.A. and Chan C.W.Y., A simple, cost-effective but highly efficient system for deriving ventricular cardiomyocytes from human pluripotent stem cells. PMID: 24564569 , Stem Cells & Development. 2014, 23(14): 1704-16.


Researcher : Chow WS
List of Research Outputs

Hui Y.L.E., Yeung C.Y., Lee P.C.H., Woo Y.C., Fong H.Y., Chow W.S., Xu A. and Lam K.S.L., Elevated Circulating Pigment Epithelium-Derived Factor Predicts the Progression of Diabetic Nephropathy in Patients With Type 2 Diabetes, The Journal of Clinical Endocrinology & Metabolism. 2014, 99: E2169-E2177.
Hui Y.L.E., Xu A., Chow W.S., Lee P.C.H., Fong H.Y., Cheung C.W.S., Tse H.F., Chau M.T., Cheung B.M.Y. and Lam K.S.L., Hypoadiponectinemia As an Independent Predictor for the Progression of Carotid Atherosclerosis: A 5-Year Prospective Study, Metabolic Syndrome and Related Disorders. 2014, 12: 517-522.
Lam K.Y.J., Lam K.S.L., Chow W.S. and Tan K.C.B., A middle-aged man with increasing body fat, Clinical Obesity. 2014, n/a-n/a.
Lee C.H.P., Hui Y.L.E., Woo Y.C., Yeung C.Y., Chow W.S., Yuen M.A.M., Fong H.Y., Xu A. and Lam K.S.L., Circulating Fibroblast Growth Factor 21 Levels Predict Progressive Kidney Disease in Subjects With Type 2 Diabetes and Normoalbuminuria, The Journal of Clinical Endocrinology & Metabolism. 2015, 100: 1368-1375.


Researcher : Chu JYS
List of Research Outputs

Chu J.Y.S., Yung S.S.Y., Chau K.M., Kam K.M. and Chan D.T.M., MicroRNA-200c inhibits TGF-β1-induced epithelial-to-mesenchymal transition and fibrogenesis in mesothelial cells, Gordon Research Conference - Fibronectin, Integrins & Related Molecules. 2015.


Researcher : Chu LW
Project Title:A dementia outreach programme in Central, Western and Southern districts of Hong Kong
Investigator(s):Chu LW, Lam KSL, Lee PWH
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:09/2003


List of Research Outputs

Chan T.C.I., Hung I.F.N., Chan K.H., Li P.Y., Li T.W., Luk J.K.H., Chu L.W. and Chan H.W.F., A Randomized Controlled Trial to Compare Immunogenicity Between Intramuscular and Intradermal Trivalent Influenza Vaccination in Nursing Home Older Adults, 20th Medical Research Conference, The University of Hong Kong, 17 Jan 2015.. 2015.
Chan T.C.I., Hung I.F.N., Luk J.K.H., Chu L.W. and Chan H.W.F., Comparing Effectiveness Between Intramuscular and Intradermal Trivalent Influenza Vaccination in Nursing Home Residents: A Randomized Controlled Trial, 20th Medical Research Conference, The University of Hong Kong, 17 Jan 2015. (Oral presentation). 2015.
Chan T.C.I., Hung I.F.N., Chan K.H., Li P.Y., Li T.W., Luk J.K.H., Chu L.W. and Chan H.W.F., Local Adverse Effect of Intradermal and Administration of Influenza Vaccination is an Indicator of Satisfactory Immunogenicity, 20th Medical Research Conference 2015, The University of Hong Kong, 17 Jan 2015. . 2015.
Chan T.C.I., Hung I.F.N., Luk J.K.H., Chu L.W. and Chan H.W.F., Prevalence of Influenza Vaccination and Associated Factors Among Chinese Nursing Home Health Care Workers, 20th Medical Research Conference 2015, The University of Hong Kong, 17 Jan 2015.. 2015.
Fan J., Cheung R.T.F., Chu L.W., Fung P.C.W., Chang C.Q., Sik H.H., ZHANG M., XIE B. and Gao J., Reduced bilateral temporal Alpha-band EEG activity during resting state in older adults, International Conference on Digital Signal Processing. Hong Kong, 2014.
Kwan S.K.J., Chu L.W., Chan H.W.F., Lee T.M.C., Law A.C.K., Mak H.K.F., Cheung R.T.F., Chang R.C.C., Lum T.Y.S. and Tang S.C.W., Comparing vascular dementia and Alzheimer’s dementia: a preliminary, cross-sectional, multimodal comparative study evaluating clinical and cognitive profile, neuroimaging, biomarkers and quantitative EEG ($240,000), Seed Funding HKU. 2014.
LEUNG T.Y., Tam H.M.K., Chu L.W., Kwok T.C.Y., Chan F., Lam L.C.W., Woo J. and Lee T.M.C., Neural Plastic Effects of Cognitive Training on Aging Brain., Neural Plasticity. 2015, 501.
Lau G.K.K., Chiu K.C.P., Shih K.C., Chu L.W., Ho S.L. and Mak W., Miller Fisher syndrome in a Chinese octogenarian presenting with dizziness, Asian Journal of Gerontology & Geriatrics. Hong Kong Academy of Medicine Press, 2014, 9:2: 93–5.
Shea Y.F., Lam M.F., Lee M.S., Mok T.M.Y., Lui S.L., Yip T.P.S., Lo W.K., Chu L.W. and Chan D.T.M., Prevalence of CMMSE defined cognitive impairment among peritoneal dialysis patients and its impact on peritonitis, Clinical And Experimental Nephrology. 2015, 21 May 2015: Epub ahead of print.
Yan E.C.W., Cheng S.T., Tiwari A.F.Y., Fong D.Y.T. and Chu L.W., Family Caregiving for Older Persons with Dementia: Caregiver Sense of Entrapment and its association with Potentially Harmful Behaviors. , International Alzheimer's Disease Conference. 2015.
Yan E.C.W., Cheng S., Kwok T., Tiwari A.F.Y., Fong D.Y.T. and Chu L.W., The implications of aggressive and non-aggressive symptoms of dementia on caregiver burden and potentially harmful behaviours, Gerontological Society of American - Sino 2015 Conference. 2015.
ZHANG L., Cheung R.T.F., Chu L.W. and Mak H.K.F., Structural MRI measures in Alzheimer’s disease and effects of ethnicity. , Alzheimer’s Association International Conference.. 2014.


Researcher : Chung ACK
Project Title:Signaling mechanisms of angiotensin II-induced epithelial-mesenchymal transition in renal tubular epithelial cells
Investigator(s):Chung ACK, Lan HY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2008




Researcher : Chung HY
List of Research Outputs

Au Y.L.E., Wong R.W.S., Mok T.M.Y., Chung H.Y., Chan Y.T.E. and Lau W.C.S., Disease activity assessment in ankylosing spondylitis in a Chinese cohort: BASDAI or ASDAS?, Clinical Rheumatology . 2014, 33: 1127-1134.
Chan C.Y., Tsang H.H., Lau W.C.S. and Chung H.Y., Prevalence of depressive and anxiety disorders and validation of the Hospital Anxiety and Depression Scale as a screening tool in axial spondyloarthritis patients, International Journal of Rheumatic Diseases. 2014, n/a-n/a.
Chen Y., Chung H.Y., Zhao C.T., Wong A., Zhen S., Tsang H.H., Lau W.C.S., Tse H.F. and Yiu K.H., Left ventricular myocardial dysfunction and premature atherosclerosis in patients with axial spondyloarthritis, Rheumatology. 2015, 54: 292-301.


Researcher : Esteban MA
List of Research Outputs

Liu L., Xu Y., He M., Zhang M., Cui F., Lu L., Yao M., Tian W., Benda C., Zhuang Q., Huang Z., Li W., Li X., Zhao P., Fan W., Luo Z., Li Y., Wu Y., Hutchins A.P., Wang D., Tse H.F., Schambach A., Frampton J., Qin B., Bao X., Yao H., Zhang B., Sun H., Pei D., Wang H., Wang J. and Esteban M.A., Transcriptional pause release is a rate-limiting step for somatic cell reprogramming., Cell Stem Cell. . 2014, 15(5): 574-588.
Wu Y., Li Y., Zhang H., Huang Y., Zhao P., Tang Y., Qiu X., Ying L., Li W., Ni S., Zhang M., Liu L., Xu Y., Zhuang Q., Luo Z., Benda C., Song H., Liu B., Lai L., Liu X., Tse H.F., Bao X., Chan W.Y., Esteban M.A., Qin B. and Pei D., 10. Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming., Nat Cell Biol. 2015, 17(6): 715-725.


Researcher : Feng Z
Project Title:30th Annual Meeting of the Society for Neuroscience Identifying and Cloning of B218 Gene, which was Down Regulated by Kainic Acid Treatment and in the Developmental Stages
Investigator(s):Feng Z
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:11/2000




Researcher : Fok AKT
List of Research Outputs

Kong S.L., Lee S.W.L., Lui G.C.S., Chan W.S., Fok A.K.T., Lee H.P. and Wu K.Y.K., VALIDATION OF ACCURACY OF HOME BLOOD PRESSURE MONITORING DEVICES BY BLAND AND ALTMAN LIMITS OF AGREEMENT AND METHOD OF VARIANCE ESTIMATES RECOVERY, Journal of the American College of Cardiology. 2015, 65: A1406.


Researcher : Fong HY
List of Research Outputs

Cheung Y.Y., Hui Y.L.E., Cheung B.M.Y., Woo Y.C., Xu A., Fong H.Y., Ong K.L., Yeung C.Y., Janus E.D., Tse H.F., Sham P.C. and Lam K.S.L., Adiponectin gene variants and the risk of coronary heart disease: a 16-year longitudinal study., Eur J Endocrinol. 2014, 171: 107-115.
Hui Y.L.E., Yeung C.Y., Lee P.C.H., Woo Y.C., Fong H.Y., Chow W.S., Xu A. and Lam K.S.L., Elevated Circulating Pigment Epithelium-Derived Factor Predicts the Progression of Diabetic Nephropathy in Patients With Type 2 Diabetes, The Journal of Clinical Endocrinology & Metabolism. 2014, 99: E2169-E2177.
Hui Y.L.E., Xu A., Chow W.S., Lee P.C.H., Fong H.Y., Cheung C.W.S., Tse H.F., Chau M.T., Cheung B.M.Y. and Lam K.S.L., Hypoadiponectinemia As an Independent Predictor for the Progression of Carotid Atherosclerosis: A 5-Year Prospective Study, Metabolic Syndrome and Related Disorders. 2014, 12: 517-522.
Lee C.H.P., Hui Y.L.E., Woo Y.C., Yeung C.Y., Chow W.S., Yuen M.A.M., Fong H.Y., Xu A. and Lam K.S.L., Circulating Fibroblast Growth Factor 21 Levels Predict Progressive Kidney Disease in Subjects With Type 2 Diabetes and Normoalbuminuria, The Journal of Clinical Endocrinology & Metabolism. 2015, 100: 1368-1375.
Woo Y.C., Cheung B.M.Y., Yeung C.Y., Lee C.H.P., Hui Y.L.E., Fong H.Y., Tso A.W.K., Tam S. and Lam K.S.L., Cardiometabolic risk profile of participants with prediabetes diagnosed by HbA1c criteria in an urban Hong Kong Chinese population over 40 years of age , Diabetic Medicine. 2015, n/a-n/a.


Researcher : Fung JYY
List of Research Outputs

Chok K.S.H., Fung J.Y.Y., Cheung T.T., Chan A.C.Y., Sharr W.W., Chan S.C. and Lo C.M., Management of recurrent hepatocellular carcinoma after liver transplant – a single center experience, Journal of Hepatitis Research. 2014, 1(3): 1014.
Chok K.S.H., Chan A.C.Y., Sharr W.W., Cheung T.T., Fung J.Y.Y., Chan S.C. and Lo C.M., Outcomes of endo-radiological approach to management of bile leakage after right lobe living donor liver transplantation, Journal of Gastroenterology and Hepatology. 2015, Epub on 2015-06-23.
Dai W.C., Sharr W.W., Chok K.S.H., Cheung T.T., Fung J.Y.Y., Chan A.C.Y., Chan S.C. and Lo C.M., Transplantation of a 2-year-old deceased-donor liver to a 61-year-old male recipient, Asian Journal of Surgery. 2015, 38: 113-116.
Fung J.Y.Y., Advances in Prevention and Management of Recurrent Hepatitis B, Asian Pacific Digestive Week - Postgraduate Course (Bali, Indonesia). 2014.
Fung J.Y.Y., HCV Management after Liver Transplantation, 2nd Chinternational Hepatitis C Forum. 2015.
Fung J.Y.Y., Wong D.K.H., Seto W.K.W., Kopaniszen M., Lai C.L. and Yuen R.M.F., Hepatitis B Surface Antigen Seroclearance: Relationship to Hepatitis B e-Antigen Seroclearance and Hepatitis B e-Antigen-Negative Hepatitis, The American Journal of Gastroenterology. 2014, 109: 1764-1770.
Fung J.Y.Y., Hepatorenal Syndrome, Macao Society of Gastroenterology & Hepatology Symposium (Macau). 2014.
Fung J.Y.Y., Management of Chronic Hepatitis B in Patients with Unknown Treatment History, The Society of Physicians of Hong Kong Symposium. 2015.
Fung J.Y.Y., Management of Hepatitis C - A Rapidly Changing Paradigm, State Key Laboratory for Liver Research Symposium. 2014.
Fung J.Y.Y., Management of Hepatitis C in the Eras of DAAs, Macao Society of Gastroenterology and Hepatology Summer Symposium. 2014.
Fung J.Y.Y., Management of Renal Impaired CHB Patients, Novartis Symposium on Chronic Hepatitis B. 2014.
Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Management of chronic hepatitis B in severe liver disease, World Journal of Gastroenterology. 2014, 20(43): 16053–61.
Fung J.Y.Y., Management of hepatitis C in the Era of DAAs, In: Macao Society of Gastroenterology & Hepatology Summer Symposium (Macau), 2014.
Fung J.Y.Y., Lam Y.F., Chok K.S.H., Seto W.K.W., Wong C.L.T., Chan A.C.Y., Chan S.C., Lai C.L., Lo C.M. and Yuen R.M.F., Modified model for end stage liver disease score accurately predicts death or liver transplantation in acute flares of chronic hepatitis B, Poster presentaion at the International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2015, 62(Suppl 2): S537.
Fung J.Y.Y., The Role of HBIG in the Era of Potent Antiviral Agents, NUCOT Liver Transplant Symposium (Singapore). 2014.
Hung I.F.N., Wong D.K.H., Poon R.T.P., Fong D.Y.T., Seto W.K.W., Fung J.Y.Y., Yuen J.C.H., Tiu T.M.R.J., Lai C.L. and Yuen R.M.F., Risk Factors and Post-resection Independent Predictive Score for the Recurrence of Hepatitis B-related Hepatocellular Carcinoma, 20th Medical Research Conference 2015, 17 Jan 2015, The University of Hong Kong, Hong Kong.. 2015.
Lai C.L., Wong D.K.H., Ip P.C.P., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lee B.P., Cullaro G., Wu C.H., Cheng C.T.K., Yuen J.C.H., Ngai W.S. and Yuen R.M.F., Profound Reduction of HBV Covalently Closed Circular DNA with Long-term Nucleoside/tide Analogue Therapy, Hepatology. 2014, 60, No. 4 (Suppl): 183A.
Lam Y.F., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Continuous entecavir for treatment naı¨ve chinese chronic hepatitis B patients in the real world setting the seven year results, 24th Annual Conference of APASL, March 12–15, 2015, Istanbul, Turkey. Hepatology International. 2015, 9 (Suppl 1): S204-5.
Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Liu S.H.K., Singh G.H.H., Lam Y.F., Fung J.Y.Y., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., A prospective study of hepatitis B reactivation in patients with prior HBV exposure undergoing hematopoietic stem cell transplantation: Reactivation association with graft-versus-host disease, Oral presentation at the International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2015, 62(Suppl 2): S194.
Seto W.K.W., Lau E.H.Y., Wu J.T.K., Hung I.F.N., Leung W.K., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., An epidemiological association between the trends of nucleoside analogue prescription and liver cancer incidence from 1999 to 2012 in Hong Kong, China, Poster presentation at the International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2015, 62(Suppl 2): S435.
Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Hepatitis B reactivation in patients with prior HBV exposure undergoing rituximab-containing chemotherapy for lymphoma: a prospective study, Journal of Clinical Oncology. 2014, 32(33): 3736-43.
Seto W.K.W., Tanaka Y., Wong D.K.H., Shinkai N., Cheung K.S., Liu S.H.K., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Longitudinal serologic profiles up to 5 years in hepatitis B surface antigen-negative chronic hepatitis B, Hepatology. 2014, 60, No. 4 (Suppl): 57A.
Wong C.L.T., Fung J.Y.Y., Chok K.S.H., Cheung T.T., Chan A.C.Y., Sharr W.W., Dai W.C., Chan S.C. and Lo C.M., Excellent outcomes of severely steatotic grafts in liver transplantation (Poster Presentation), World Transplant Congress 2014, San Francisco, USA, 26-31 July 2014.
Wong D.K.H., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Zhang J., Hung I.F.N., Lai C.L. and Yuen R.M.F., Identification of Hepatitis B Virus DNA Polymerase Sequences to Predict Virological Response to Entecavir Therapy, Health Research Symposium 2014, Hong Kong, 15 Nov 2014. (Poster presentation). 2014.
Wong D.K.H., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Identification of hepatitis B virus DNA reverse transcriptase variants associated with partial response to entecavir, Hong Kong Medical Journal. 2015, 21(Suppl 4): 35-8.
Wong D.K.H., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Hung I.F.N., Young J.L.P., Yuen J.C.H., Ngai W.S., Yuen R.M.F. and Lai C.L., Reduction of hepatitis B core related antigen by long term nucleoside nucleotide analogue therapy and its correlation with intrahepatic HBV DNA reduction, 24th Annual Conference of APASL, March 12–15, 2015, Istanbul, Turkey. Hepatology International. 2015, 9 (Suppl 1): S202.
ZHANG A., Wong D.K.H., Huang F.Y., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Evolutionary changes of hepatitis B virus pre-S mutations prior to development of hepatocellular carcinoma, Poster presentation at the International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2015, 62(Suppl 2): S543.


Researcher : Fung SL
List of Research Outputs

Wong C.F., Lau G.K.K. and Fung S.L., Endobronchial tuberculosis: Always a diagnostic challenge, QJM. 2015.


Researcher : GAO Y
List of Research Outputs

GAO Y. and Mok T.M.Y., Cognitive dysfunction and disease and non-disease associated factors in systemic lupus erythematosus: Longitudinal perspectives , PhD thesis. 2015.
GAO Y., Wan H.Y., Lau E.Y., Lau C.S. and Mok T.M.Y., Cognitive function in systemic lupus erythematosus patients with past history of neuropsychiatric manifestations: A longitudinal study, Arthritis Rheum 2014;66:S1162 (Abstract 2654) . 2014.
GAO Y., Lo Y., Wan H.Y., Lau Y.Y., Lau C.S. and Mok T.M.Y., Cognitive function in systemic lupus erythematosus patients with past history of neuropsychiatric manifestations: A longitudinal study, Hong Kong Medical Journal 2015;21:p20 (Abstract 22) . 2015.
GAO Y., Lo Y., Lau C.S. and Mok T.M.Y., Cognitive symptoms and associated disease and non-disease related factors in patients with systemic lupus erythematosus: A longitudinal study, Arthritis Rheum 2014;66;S1162 (Abstract 2658) . 2014.
GAO Y., Cheung R.T.F., Gao J., Lau E.Y.Y., WAN H.Y. and Mok T.M.Y., Evaluation of cognitive function by electrophysiological study in systemic lupus erythematosus patients with previous neuropsychiatric involvement. European League of Association of Rheumatology (EULAR) 2015, Ann Rheum Dis 2015; 74(Suppl2), 2015, 74(Suppl2): 1099.
GAO Y., Lo Y. and Mok T.M.Y., Symptoms of attention deficit hyperactivity disorder in patients with systemic lupus erythematosus. European League of Association of Rheumatology (EULAR) 2015 Ann Rheum Dis 2015;74(Suppl2), 2015, 74(Suppl2): 575.
GAO Y., Lo Y. and Mok T.M.Y., Symptoms of attention deficit hyperactivity disorder in patients with systemic lupus erythematosus, Lupus. 2015.
GAO Y., Lo Y. and Mok T.M.Y., Systemic lupus erythematosus patients with past neuropsychiatric involvement is associated with worse cognitive impairment : a longitudinal study. European League of Association of Rheumatology (EULAR) 2015 Ann Rheum Dis 2015;74(Suppl2), 2015, 74(Suppl2): 1099.


Researcher : GE X
List of Research Outputs

Tang E.H.C., Cai Y., Wong C.K., Rocha V.Z., Sukhova G.K., Shimizu K., GE X., Vanhoutte P.M.G.R., Libby P. and Xu A., Activation of prostaglandin E2-EP4 signaling reduces chemokine production in adipose tissue , Journal of Lipid Research. 2015, 56(2): 358-368.


Researcher : GUO Y
List of Research Outputs

Guo Y., Chung S.K., Siu D.C.W., Kwan S.C., Ho W.L., Yeung P.K.K. and Chan K.H., Endothelin-1 overexpression exacerbate experimental allergic encephalomyelitis, Journal of Neuroimmunology. 2014.
HU J., WONG N.K., YE S., Chen X., LU M., ZHAO Q., GUO Y., Ma C.H., Leung A.Y.H., Shen J. and Yang D., Fluorescent Probe HKSOX-1 for Imaging and Detection of Endogenous Superoxide in Live Cells and In VivoJournal of the American Chemical Society, Journal of the American Chemical Society. 2015, 137: 6837-6843.
SHI X., HE B., Ma C.H., GUO Y., Chi Y., Zhang W., Zhang Y., Wen Z., Cheng T. and Leung A.Y.H., Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish, Blood. 2015, 125: 2974-2984.


Researcher : Gao J
Project Title:The relevance of brain connectivity in resting, alert and meditation states: a concurrent EEG/fMRI study
Investigator(s):Gao J, Sik HH, Hung YS
Department:Centre of Buddhist Studies
Source(s) of Funding:Small Project Funding
Start Date:06/2013
Completion Date:11/2014


Project Title:International conference on contemlative studies; Decreased chaotic EEG signal during mindfulness-based stress reduction (MBSR) meditation/Reduced response to stressful events during chanting Amitofo: A combined fMRI and EEG study
Investigator(s):Gao J
Department:Centre of Buddhist Studies
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2014
Completion Date:11/2014


List of Research Outputs

GAO Y., Cheung R.T.F., Gao J., Lau E.Y.Y., WAN H.Y. and Mok T.M.Y., Evaluation of cognitive function by electrophysiological study in systemic lupus erythematosus patients with previous neuropsychiatric involvement. European League of Association of Rheumatology (EULAR) 2015, Ann Rheum Dis 2015; 74(Suppl2), 2015, 74(Suppl2): 1099.


Researcher : Gu P
List of Research Outputs

Gu P., Hui X., Vanhoutte P.M.G.R., Lam K.S.L. and Xu A., Deletion of SIRT1 in perivascular adipose tissue accelerates obesity-induced endothelial dysfunction , ASCEPT-BPS2015.


Researcher : Guo Y
List of Research Outputs

Guo Y., Chung S.K., Siu D.C.W., Kwan S.C., Ho W.L., Yeung P.K.K. and Chan K.H., Endothelin-1 overexpression exacerbate experimental allergic encephalomyelitis, Journal of Neuroimmunology. 2014.
HU J., WONG N.K., YE S., Chen X., LU M., ZHAO Q., GUO Y., Ma C.H., Leung A.Y.H., Shen J. and Yang D., Fluorescent Probe HKSOX-1 for Imaging and Detection of Endogenous Superoxide in Live Cells and In VivoJournal of the American Chemical Society, Journal of the American Chemical Society. 2015, 137: 6837-6843.
SHI X., HE B., Ma C.H., GUO Y., Chi Y., Zhang W., Zhang Y., Wen Z., Cheng T. and Leung A.Y.H., Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish, Blood. 2015, 125: 2974-2984.


Researcher : HE B
List of Research Outputs

SHI X., HE B., Ma C.H., GUO Y., Chi Y., Zhang W., Zhang Y., Wen Z., Cheng T. and Leung A.Y.H., Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish, Blood. 2015, 125: 2974-2984.


Researcher : HUANG Z
List of Research Outputs

Pan K., LEE T.H.J., HUANG Z. and Wong C.M., Coupling and Coordination in Gene Expression Processes with Pre-mRNA Splicing, International Journal of Molecular Sciences. 2015, 16(3): 5682-5696.
Wong C.M., WANG Y., LEE T.H.J., HUANG Z., Wu D., Xu A. and Lam K.S.L., Adropin is a brain membrane-bound protein regulating physical activity via NB-3/Notch signaling pathway in mice, The Journal of Biological Chemistry. 2014.
Wong C.M., Pan K., HUANG Z. and LEE T.H.J., Current perspectives on the role of TRAMP in nuclear RNA surveillance and quality control, Research and Reports in Biochemistry. 2015, 5: 111-117.


Researcher : Hai SHJJ
List of Research Outputs

Chan P.H.M., Li W., Hai S.H.J.J., Tse H.F. and Siu D.C.W., Impact of Antithrombotic Therapy in Atrial Fibrillation on the Presentation of Coronary Artery Disease, PLOS ONE. 2015, 10: e0131479.
Chan P.H.M., Hai S.H.J.J. and Siu D.C.W., Response to Letter Regarding Article, "Ischemic Stroke and Intracranial Hemorrhage With Aspirin, Dabigatran, and Warfarin: Impact of Quality of Anticoagulation Control", Stroke. 2015, 46: e72-e72.
Hai S.H.J.J., Chan P.H.M., Tse H.F. and Siu D.C.W., Slow Heart Rate Predicts New Occurrence of Atrial Fibrillation, Heart, Lung and Circulation. 2015.
Ho C.W., Ho M.H., Chan P.H.M., Hai S.H.J.J., Cheung E., Yeung C.Y., Lau G.K.K., Chan K.H., Lau C.P., Lip G.Y., Leung G.K.K., Tse H.F. and Siu D.C.W., Ischemic stroke and intracranial hemorrhage with aspirin, dabigatran, and warfarin: impact of quality of anticoagulation control, Stroke. 2015.


Researcher : Ho JCM
Project Title:MERIT – A phase II marker identification trial for TarcevaTM in second line NSCLC patients
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:F Hoffmann-La Roche and Co. Ltd. - General Award
Start Date:07/2005


Project Title:A Phase III, radonmized, double-blinded, parallel group, multi centre study to access the efficacy and safety of ZD6474 (ZACTIMA TM) in combination with pemetrexed (Alimta) versus pemetrexed alone in patients with locally-advanced or metastatic (stage IIIB or IV) non-small cell lung cancer (NSCLC) after failure of 1st line anti-cancer therapy
Investigator(s):Ho JCM, Wong KYM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:02/2007


Project Title:A rabdomized, double blind, placebo controlled, phase IIIB trial comparing bevacizumab therapy with or without erlotinib after completion of chemotherapy with bevacizumab for the first line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:08/2007


Project Title:The effect of inhaled corticosteroids on the risk of diabetes, impaired glucose tolerance and characteristics of glucose regulation in adults with asthma: a population based matched controlled study
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Lee Wing Tat Fund
Start Date:08/2007


Project Title:A Phase 3, multicentre, randomized, placebo-controlled, double-bind trial of AMG 706 in combination with paclitaxel and carboplatin for advanced non-small cell lung cancer
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:11/2007


Project Title:A phase III, randomized, double-blind, active-controlled, parallel-group study, conducted under in-house building conditions, to examine the safety, tolerability, and efficacy of a single dose of intravenous MK-0517 for the prevention of chemotherapy-induced nausea and vomiting (CINV) associated wtih Cisplatin chemotheray
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:06/2008


Project Title:A randomized, multicenter phase II study to explore whether biomarkers correlate with treatment outcome in chemo-naive patients with advanced or recurrent non-squamous non-small cell lung cancer, who receive treatment with bevacizumab (at a dose of either 7,5mg.kg or 15mg/kg) in addition to carboplain-based chemotherapy (gemcitabine or paclitaxed)
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:12/2008


Project Title:In-vitro combination of arsenic trioxide and chemotherapy in non-small cell lung cancer
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Hong Kong Lung Foundation Research Grant
Start Date:02/2009


Project Title:Multicenter, randomized, double-blind, phase III trial to investigate the efficacy and safety of oral BIBF 1120 plus standard pemetrexed therapy compared to placebo plus standard pemetrexed therapy in patients with stage IIIB/IV or recurrent non small cell lung cancer after failure of first line chemotherapy
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:04/2009


Project Title:A randomised, placebo-controlled, double-blind phase III study of sequential administration of Tarceva (erlotinib) or placebo in combination with gemcitabine/platinum as first-line treatment in patients with stage IIIB/V non-small cell lung cancer (NSCLC)
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:04/2009


Project Title:A Phase III, multi-center, placebo–controlled trial of Sorafenib (BAY 43-9006) in patients with relapsed or refractory advanced predominantly non squamous Non-Small Cell Lung Cancer (NSCLC) after 2 or 3 previous treatment regimens.
Investigator(s):Ho JCM, Lam CLD, Lam CMJ, Wang KLJ, Wong KYM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:08/2009


Project Title:Phase 2, open-label single arm study of the efficacy and safety of PF 02341066 in patients with advanced non-small cell lung cancer (NSCLC) harboring a translocation or inversion involving the anaplastic lymphoma kinase (ALK) gene locus
Investigator(s):Ho JCM, Lam CLD, Wong KYM, Lam CMJ, Ip MSM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:04/2010


Project Title:Phase 3, randomized, open-label study of the efficacy and safety of PF-02341066 versus standard of care chemotherapy (pemetrexed or docetaxel) in patients with advanced nonsmall cell lung cancer (NSCLC) harbouring a translocation or inversion event involving the anaplastic lymphoma kinase (ALK) gene locus
Investigator(s):Ho JCM, Lam CLD, Wong KYM, Lam CMJ, Ip MSM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:04/2010


Project Title:Randomized controlled trial of S-1 versus docetaxel in patients with non-small cell lung cancer who have received a platinum-based treatment
Investigator(s):Ho JCM, Lam CLD
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:08/2010


Project Title:In-vitro combination of arsenic trioxide and chemotherapy in non-small cell lung cancer
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:The Hong Kong Anti-Cancer Society (HKACS) - General Award
Start Date:03/2011


Project Title:A Randomized, Double-Blind, Phase 2 Study of erlotinib (Tarceva®) in combination with OSI 906 or placebo in Chemonaive Patients with Advanced NSCLC with Activating Mutations of the Epidermal Growth Factor Receptor (EGFR) Gene
Investigator(s):Ho JCM, Lam CLD
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:04/2011


Project Title:Randomized, Multicenter, Double-Blind, Phase 3 Trial Comparing the Efficacy of Ipilimumab in Addition to Paclitaxel and Carboplatin versus Placebo in Addition to Paclitaxel and Carboplatin in Subjects with Stage IV/Recurrent Non-Small Cell Lung Cancer (NSCLC)
Investigator(s):Ho JCM, Lam CLD
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:05/2011


Project Title:In vitro study of arsenic trioxide in treatment of malignant pleural mesothelioma
Investigator(s):Ho JCM, Lam SK
Department:Medicine
Source(s) of Funding:Pneumoconiosis Compensation Fund Board - General Award
Start Date:07/2011


Project Title:A Phase III Randomised, Double blind, Placebo controlled, Parallel, Multicentre Study to Assess the Efficacy and Safety of continuing IRESSATM 250 mg in addition to Chemotherapy versus Chemotherapy alone in Patients who have Epidermal Growth Factor Receptor (EGFR)Mutation Positive Locally advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) and have progressed on First Line IRESSATM
Investigator(s):Ho JCM, Lam CLD
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:02/2012


List of Research Outputs

Cheung T.S., SONG T., Ng T.B., Wu F.H., Lao L., Tang S.C.W., Ho J.C.M., Zhang Y. and Sze C.W.S., Therapeutic Effects of Herbal Chemicals in Traditional Chinese Medicine on Alzheimer's Disease, Curr Med Chem . 2015, 22: 2392-2403.
Cho S.H., David-Wang A., Ho J.C.M., Jeong J.W., Liam C.K., Lin J.T., Muttalif A.R., Perng D.W., Tang T.L., Yunus F. and Neira G., Discrepancy between patient-perception and guideline-defined asthma control in Asia: a survey of over 2400 patients, 19th Congress of Asian Pacific Society of Respirology, Bali, 13-16 November, Respirology. 2014, 19 (suppl 3): 5 (abstract O-A-013).
Cho S.H., David-Wang A., Ho J.C.M., Jeong J.W., Liam C.K., Lin J.T., Muttalif A.R., Perng D.W., Tan T.L., Yunus F. and Neira G., Identification of attitudinal clusters in patients with asthma: analysis from REALISE Asia. 19th Congress of Asian Pacific Society of Respirology, Bali, 13-16 November, Respirology. 2014, 19 (suppl 3): 4 (abstract O-A-11).
David-Wang A., Tan T.L., Yunus F., Cho S.H., Ho J.C.M., Jeong J.W., Liam C.K., Lin J.T., Muttalif A.R., Perng D.W. and Neira G., Preferred sources of information on asthma: data from multinational survey of patients in Asia, 19th Congress of Asian Pacific Society of Respirology, Bali, 13-16 November, Respirology. 2014, 19 (suppl 3): 71 (abstract P-A-023).
Ho J.C.M., Article on ALK-positive lung cancer [ in HK Econonic Times], 3 July, 2014.
Ho J.C.M., Asthma insights and management surveys, impact on healthcare utilization costs. MSD satellite symposium at ERS 2014, Munich, Germany, 8 September, 2014.
Ho J.C.M., Yunus F., Liam C.K., David-Wang A., Cho S.H., Jeong J.W., Lin J.T., Muttalif A.R., Perng D.W., Tan T.L. and Neira G., Awareness and usage of inhalers among patients with asthma: findings from REALISE Asia, 19th Congress of Asian Pacific Society of Respirology, Bali- 13-16 November, Respirology. 2014, 19 (suppl. 3): 70 (abstract P-A-022).
Ho J.C.M., EGFR-driven advanced NSCLC: optimal first line treatment choices and what to do after progression. Roche Oncology Scientific Meeting, Penang, Malaysia, 7 March, 2015.
Ho J.C.M., How I manage patients who develop acquired resistance to 1st line EGFR TKI. Meet-the-Expert round table meeting, Kuala Lumpur, Malaysia, 22 May, 2015.
Ho J.C.M., How I treat EGFR mutation positive advanced NSCLC. AstraZeneca 1st National Oncology Summit, Kuala Lumpur, Malaysia, 23 May, 2015.
Ho J.C.M., Interview on "Blocking new target inhibits lung cancer growth, metastasts" [in Bio World], 27 January, 2015.
Ho J.C.M., Interview on Air on ALK-positive lung cancer [at Digital Broadcasting Corporation HK Ltd], 3 July, 2014.
Ho J.C.M., Lung cancer screening: are we ready for the prime time? Hong Kong College of Physicians Annual Scientific Meeting, 18 October, 2014.
Ho J.C.M., Re-biopsy when disease progresses - what do we test? Invited Lecture at Asian Pacific Lung Cancer Conference, Kuala Lumpar, Malaysia, 6 November, 2014.
Ho J.C.M., Recent molecular targets in treatment of NSCLC. Eli Lilly symposium (exchange between HK/Taiwan), Hong Kong, 13 September, 2014.
Ho J.C.M., The continuing role of chemotherapy in world of TKI. Hong Kong College of Radiologist Annual Scientific Meeting, 2 November, 2014.
Ho J.C.M., The first irreversible ErbB family blocker i the treatment of EGFR mutation positive NSCLC. BI evening symposium, Hong Kong 23 April, 2015.
LEUNG L.L., Lam S.K. and Ho J.C.M., Arsenic trioxide Suppresses Tumour Growth in Squamous Cell Lung Carcinoma , 20th Medical Research Conference. Hong Kong Medical Journal, 2015, 21: 53.
LI Y., Lam S.K., ZHENG C., LEUNG L.L. and Ho J.C.M., The effect of tumor microenvironment on autophagy and sensitivity to targeted therapy in EGFR-mutated lung adenocarcinoma , 21st Hong Kong International Cancer Congress. 2014.
LIU J., Tang S.C.W., Sze C.W.S., Lao L., Ho J.C.M., Lee C.K.F. and Zhang Y., Paper and poster presentation: Traditional Chinese Medicine is a Promising Alternative for the Management of Diabetic Nephropathy. , In: Liu JY, Tang SCW, Sze SCW, Lao LX, Ho JCM, Lee CKF, Zhang YB*. , The 8th Pong Ding Yuen International Symposium on Traditional Chinese Medicine cum, The 2nd International Chinese Symposium on Free Radical Research & The 6th Symposium for Three Districts of Cross-straits on Free Radical Research 15 -16/11/2014, Hong Kong. Organized by Commission of Free Radical Biology and Medicine, Biophysical Society of China and Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2014.11.15-16. . 2014, p-60.
Lam C.L.D., Tam C.C.T., Lau K.M., Wong W.M., Hui K.M.C., Lam J.C., Wang J.K., Lui M.S.M., Ho J.C.M. and Ip M.S.M., Plasma EGFR Mutation Detection Associated With Survival Outcomes in Advanced-Stage Lung Cancer, Clinical Lung Cancer [Epub ahead of print]. 2015.
Lam S.K., LI Y., ZHENG C., LEUNG L.L. and Ho J.C.M., Combination Effect of Arsenic Trioxide and FGFR Inhibitor through Downregulation of FGFR, Akt and Erk in Squamous Cell Lung Carcinoma, 21st Hong Kong International Cancer Congress. 2014.
Lam S.K., LI Y., ZHENG C. and Ho J.C.M., Downregulation of Thymidylate Synthase and E2F1 by Arsenic Trioxide in Mesothelioma , Work Injury Prevention and Rehabilitation 2014.
Lam S.K., LI Y., ZHENG C. and Ho J.C.M., Downregulation of thymidylate synthase and E2F1 by arsenic trioxide in mesothelioma., International journal of oncology. 2014, 46: 113-22.
Lam S.K., LI Y., ZHENG C., LEUNG L.L. and Ho J.C.M., E2F1 Downregulation by Arsenic Trioxide in Lung Adenocarcinoma, International Journal of Oncology. 2014, 45: 2033-43.
Lam S.K., LEUNG L.L. and Ho J.C.M., Massive degradation in FGFR/Akt/Erk signaling by arsenic trioxide and FGFR inhibitor PD173074 in squamous cell lung carcinoma SK-MES-1, 20th Medical Research Conference. Hong Kong Medical Journal, 2015, 21: 30.
Li Y.V., Lam S.K., Zheng C. and Ho J.C.M., The Effect of Tumor Microenvironment on Autophagy and Sensitivity to Targeted Therapy in EGFR-Mutated Lung Adenocarcinoma, Journal of Cancer. 2015, 6: 382-386.
Liam C.K., Andarini S., Lee P., Ho J.C.M., Chau N.Q. and Tscheikuna J., Lung cancer staging now and in the future, Respirology. 2015, 20(4): 526-534 [Epub 14 Feb 2015].
Muttalif A.R., Lin J.T., Cho S.H., David-Wang A., Ho J.C.M., Jeong J.W., Liam C.K., Perng D.W., Tan T.L., Yunus F. and Neira G., Differences in patient-perceptions and levels of asthma control across 8 Asia countires: data from the REALISE Asia survey, 19th Congress of Asian Pacific Society of Respirology, Bali, 13-16 November, Respirology. 2014, 19 (suppl 3): 74 (abstract P-A-031).
Perng D.W., Laim C.K., Yunus F., Cho S.H., David-Wang A., Ho J.C.M., Jeong J.W., Lin J.T., Muttalif A.R., Tan T.L. and Neira G., Patterns of hospitalization and healthcare utilization across attitudinal clusters: analysis from patient survey in Asia, 19th Congress of Asian Pacific Society of Respirology, Bali, 13-16 November, Respirology. 2014, 19 (suppl 3): 6 (abstract O-A-014).
SONG T., Sze C.W.S., Ng T.B., Tang S.C.W., Ho J.C.M. and Zhang Y., Session 3 Chairman. Speaking and abstract: Investigation of Effect Mechanisms and Clinical Study of Polysaccharide of Dendrobium officinale in Alleviating Cigarette-Induced COPD. , In: Song TH, Sze CW, Ng TB, Tang CW, Ho CM, Zhang YB*. , Shanghai, China. Co-organized by the Phytochemical Society of Europe and the Phytochemical Society of Asia. Jun 26-29, 2015. . 2015, p-18.
ZHENG C., Lam S.K., LI Y., LEUNG L.L. and Ho J.C.M., Arsenic trioxide-induced cytotoxicity in small cell lung cancer via altered redox homeostasis and mitochondrial integrity , 21st Hong Kong International Cancer Congress. 2014.
ZHENG C., Lam S.K., LI Y. and Ho J.C.M., Arsenic trioxide-induced cytotoxicity in small cell lung cancer via altered redox homeostasis and mitochondrial integrity., International journal of oncology. 2014, 46: 1067-1078.
Zhang Y., Sze C.W.S., Tang S.C.W., Ho J.C.M., SONG T. and LIU J., Invention of Efficacy on Polysaccharide of Dendrobium officinale in Alleviating Cigarette-Induced Pulmonary Inflammation Though Experimental Rats. , In: Zhang YB*, Sze CW, Tang CW, Ho CW, Song TH, Liu JY., China patent office. 2014.


Researcher : Ho SL
Project Title:Biochemical markers in a large Chinese kindred with autosomal dominant motor neurone disease associated with SOD1 mutation
Investigator(s):Ho SL, Song Y, Wang Y
Department:Medicine
Source(s) of Funding:Liu Po Shan/Dr Vincent Liu Endowment Fund for Motor Neuron diseases - General Award
Start Date:04/2007


Project Title:Pathophysiological study of Parkinson's disease associated with leucine-rich repeat kinase 2 (LRRK2) gene mutation
Investigator(s):Ho SL, Ho WL, Siu DCW
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2014


List of Research Outputs

Ho W.L., Ho S.L. and Ramsden D.B., Human Catechol-O-Methyltransferase (COMT) Assay, United State Patent & Trademark Office (USPTO): Granted Patent US 20100081147 A1. 2014.
Ho W.L., Pang S.Y.Y., Li M., Tse H.M., Kung M.H.W., Sham P.C. and Ho S.L., PMCA4 (ATP2B4) mutation in familial spastic paraplegia causes delay in intracellular calcium extrusion, Brain and Behavior. 2015, 5: n/a-n/a.
LI J., Deng S.J., WANG P., Yang W., Ho S.L., Sham P.C., Wang J.J. and Li M., wKGGSeq: A Comprehensive Strategy-Based and Disease-Targeted Online Framework to Facilitate Exome Sequencing Studies of Inherited Disorders, Human Mutation. 2015, 36: 496-503.
LI T.H., Hui S.K., Chua S.E., McAlonan G.M., Ho S.L. and Mak H.K.F., Assessing Iron Load in Deep Grey Matter Brain Nuclei of Parkinson's Disease with L2-Regularized Quantitative Susceptibility Mapping, Joint Annual Meeting ISMRM-ESMRMB . 2015.
Lau G.K.K., Wong Y.K., Teo K.C., Li O.Y., Chan J., Chan S., Cheung R., Wong E., Wong E., Ho S.L., Mak H.K.F. and Rothwell P.M., Clinical correlates and prognostic implications of cerebral microbleeds detected by susceptibility weighted imaging in Chinese with ischaemic stroke, 10th International Symposium of Healthy Aging. 2015.
Lau G.K.K., Wong Y.K., Teo K.C., Li O.Y., Chan J., Chan S., Cheung R., Wong E., Wong E., Ho S.L., Mak H.K.F. and Rothwell P.M., Clinical correlates and prognostic implications of cerebral microbleeds detected by susceptibility weighted imaging in Chinese with ischaemic stroke, European Stroke Organisation Conference. 2015.
Lau G.K.K., Chan L.K., Li O.Y., Yuen T.K., Wong Y.K., Chan K.H., Chan J.F.W., Chang S.K.R., Cheung R.T.F., Doherty I., Ho S.L., Hon F.K.S., Kwan S.K.J., Lee R., Leung G.K.K., Mak W., Mak H.K.F., Shih K.C. and Tsang C.O.A., Establishing an eLearning Platform in Clinical Neurosciences, East-West Alliance Global Symposia 2014.
Lau G.K.K., Chiu K.C.P., Shih K.C., Chu L.W., Ho S.L. and Mak W., Miller Fisher syndrome in a Chinese octogenarian presenting with dizziness, Asian Journal of Gerontology & Geriatrics. Hong Kong Academy of Medicine Press, 2014, 9:2: 93–5.
Lau G.K.K., Chan L.K., Chan K.H., Chang S.K.R., Chang R.C.C., Cheung R.T.F., Doherty I., Ho S.L., Hon S.F.K., Kwan S.K.J., Lee R., Leung G.K.K., Mak W., Shih K.C. and Tsang C.O.A., ePoster Award (First Prize), Title: Establishing an eLearning Platform in Clinical Neurosciences at HKU, HKU Li Ka Shing Faculty of Medicine Frontiers Series – East-West Alliance Global Symposia. 2014.
Lee J.C., Pang S.Y., Lam C.L.D., Tse A.C., Lau G.K.K., Chang S.K.R., Ho S.L., Cheung R.T.F., Mak W., Hon F.K.S., Chang C.K., Teo K.L. and Chan K.H., Myasthenic crisis in patients with generalised myasthenia gravis. Hong Kong Academy of Medicine, 2014., 2015.
Li M., Ho W.L., Pang S.Y.Y., Tse H.M., Kung M.H.W., Sham P.C. and Ho S.L., PMCA4 (ATP2B4) Mutation in Familial Spastic Paraplegia, PLoS ONE. 2014.
Yao N., Cheung C., Pang S.Y.Y., Chang S.K.R., Lau G.K.K., Suckling J., Yu K., Mak H.K.F., Chua S.E., Ho S.L. and McAlonan G.M., Multimodal MRI of the hippocampus in Parkinson's disease with visual hallucinations, Brain Structure and Function. 2014.
Yao N., Pang S., Cheung C., Chang S.K.R., Lau G.K.K., Suckling J., Yu K., Mak H.K.F., McAlonan G., Ho S.L. and Chua S.E., Resting activity in visual and corticostriatal pathways in Parkinson’s disease with hallucinations, Parkinsonism and Related Disorders. 2015.


Researcher : Ho WL
Project Title:Pathogenic mechanism of leucine-rich repeat kinase 2 (LRRK2) R1441G mutation on synaptic mitochondrial dysfunction associated with Parkinson’s disease
Investigator(s):Ho WL, Ho SL, Liu H
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2014


Project Title:Neurotoxic effects of environmental estrogenic endocrine disruptive compounds on brain dopamine homeostasis
Investigator(s):Ho WL, Ho SL, Leung KMY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2015


List of Research Outputs

Guo Y., Chung S.K., Siu D.C.W., Kwan S.C., Ho W.L., Yeung P.K.K. and Chan K.H., Endothelin-1 overexpression exacerbate experimental allergic encephalomyelitis, Journal of Neuroimmunology. 2014.
Ho W.L., Ho S.L. and Ramsden D.B., Human Catechol-O-Methyltransferase (COMT) Assay, United State Patent & Trademark Office (USPTO): Granted Patent US 20100081147 A1. 2014.
Ho W.L., Pang S.Y.Y., Li M., Tse H.M., Kung M.H.W., Sham P.C. and Ho S.L., PMCA4 (ATP2B4) mutation in familial spastic paraplegia causes delay in intracellular calcium extrusion, Brain and Behavior. 2015, 5: n/a-n/a.
Li M., Ho W.L., Pang S.Y.Y., Tse H.M., Kung M.H.W., Sham P.C. and Ho S.L., PMCA4 (ATP2B4) Mutation in Familial Spastic Paraplegia, PLoS ONE. 2014.
Ng C.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Lam K.S.L., Xu A. and Chan K.H., Adiponectin deficiency induced cognitive dysfunction and Alzheimer’s disease pathogenesis in mice through the disruption of insulin sensitivity and inactivated AMPK signaling , 67th American Academy of Neurology Annual Meeting. 2015.
Ng C.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Lam K.S.L., Xu A. and Chan K.H., Research Travel Scholarship 2015, American Academy of Neruology. 2015.


Researcher : Hon FKS
List of Research Outputs

Lau G.K.K., Chan L.K., Li O.Y., Yuen T.K., Wong Y.K., Chan K.H., Chan J.F.W., Chang S.K.R., Cheung R.T.F., Doherty I., Ho S.L., Hon F.K.S., Kwan S.K.J., Lee R., Leung G.K.K., Mak W., Mak H.K.F., Shih K.C. and Tsang C.O.A., Establishing an eLearning Platform in Clinical Neurosciences, East-West Alliance Global Symposia 2014.
Lee J.C., Pang S.Y., Lam C.L.D., Tse A.C., Lau G.K.K., Chang S.K.R., Ho S.L., Cheung R.T.F., Mak W., Hon F.K.S., Chang C.K., Teo K.L. and Chan K.H., Myasthenic crisis in patients with generalised myasthenia gravis. Hong Kong Academy of Medicine, 2014., 2015.


Researcher : Hoo RLC
Project Title:The inter-relationship between A-FABF, endoplasmic reticulum stress and autophagy in the pathogenesis of obesity-induced imflammation
Investigator(s):Hoo RLC, Zhang J
Department:Medicine
Source(s) of Funding:National Natural Science Foundation of China (NSFC) - General Program
Start Date:01/2013


Project Title:Interplay between adipocyte fatty acid binding protein and endoplasmic reticulum stress in toxic lipids-induced inflammation in macrophages
Investigator(s):Hoo RLC, Xu A
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2013


Project Title:The role of adipocyte fatty acid binding protein in diet-induced obesity
Investigator(s):Hoo RLC, Xu A, Lam KSL
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2013


Project Title:Adipocyte fatty acid binding protein (A-FABP) as a potential mediator of cardiac dysfunction and heart failure related to diabetes and obesity
Investigator(s):Hoo RLC, Xia Z, Xu A
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2014


Project Title:The pathological role of adipocyte fatty acid binding protein in alcoholic fatty liver disease.
Investigator(s):Hoo RLC, Xu A
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2014


Project Title:Adipocyte fatty acid binding protein (A-FABP) is a potential therapeutic target of both alcoholic and non-alcoholic steatohepatitis
Investigator(s):Hoo RLC, Xu A
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2015


Project Title:Deciphering the role of lipid chaperone fatty acid binding protein 4 in the development of obesity-induced diabetic nephropathy
Investigator(s):Hoo RLC, Xu A
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2015


List of Research Outputs

Hoo R.L.C., Editorial board member, Scientific Reports (Endocrine). Nature Publishing Group, 2014.
KWOK H.M., Cheng K.Y., Li F.Y.L., Chan Y.C.C., Hoo R.L.C., Ye D., Xu A. and Lam K.S.L., Inactivation of c-Jun N-terminal Kinase in Adipose Tissue Alleviates Atherosclerosis in Diet-induced Obese ApoE-deficient Mice, 83rd European Atherosclerosis Society Congress. 2015.
Liu Y., Sen S., Wannaiampikul S., Palanivel R., Hoo R.L.C., Isserlin R., Bader G., Tungtrongchitr R., Deshaies Y. and Xu A., Metabolomic profiling in liver of adiponectin knockout mice uncovers lysophospholipid metabolism as an important target of adiponectin action, Biochemical Journal. 2015, 469(1): 71-82.
SHU L., WU X., CHEONG L.Y., Zhou M., Lam K.S.L., Xu A. and Hoo R.L.C., Adipocyte fatty acid binding protein (A-FABP) is a potential regulator of adaptive thermogenesis, Tenth international symposium on healthy aging"A decade of positive aging ". 2015.
Yau S.Y., LI A., Hoo R.L.C., Ching Y.P., Christie B... .R..., Lee T.M.C., Xu A. and So K.F., Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin, Proceedings of the National Academy of Sciences. United States of America, Proceedings of the National Academy of Sciences of the US, 2014, 111: 15810-15815.
Zhou M., PAN Y., SHU L., Lam K.S.L., Xu A. and Hoo R.L.C., A-FABP is a potential mediator of diabetic cardiomyopathy and ischemic reperfusion induced cardiac injury , 17th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM) . 2014.


Researcher : Hsu ASJ
List of Research Outputs

Hsu A.S.J. and Yuen R.M.F., Malabsorption disorders, In: Hasan M, Akbar SMF, Mantab MA , Textbook of Hepato-Gastroenterology. Jaypee Brothers Medical Publishers (P) Ltd, 2015, Chapter 7: 61-7.
Hung I.F.N., Liu S.H.K., Tan V.P.Y., Hsu A.S.J., Seto W.K.W., Tong S.M. and Leung W.K., Seven-day Rifabutin Containing Triple Therapy Versus Seven-day Levofloxacin Containing Quadruple Therapy as Second-line Treatment for Helicobacter pylori in Chinese Patients: an Open Label, Randomized Trial, Digestive Disease Week 2015. (Oral presentation). 2015, S149.
Poon R.T.P., Cheung T.T., Kwok P.C., Lee A.S., Li T.W., Loke K.L., Chan S.L., Cheung M.T., Lai T.W., Cheung C.C., Cheung F.Y., Loo C.K., But Y.K.D., Hsu A.S.J., Yu S.C. and Yau T.C.C., Hong Kong consensus recommendations on the management of hepatocellular carcinoma, Liver Cancer. 2015, 4(1): 51-69.


Researcher : Hu HC
Project Title:A study to validate a symptom severity questionnaire for patents with functional dyspepsia
Investigator(s):Hu HC, Lam CLK
Department:Medicine
Source(s) of Funding:Health Services Research Fund - Full Grants
Start Date:10/1998




Researcher : Huang FY
Project Title:Role of estorgen-inducible MiR23a in hepatocellular carcinoma
Investigator(s):Huang FY, Wong DKH, Fung JYY, Seto WKW, Lai CL, Yuen RMF
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:05/2014


List of Research Outputs

Huang F.Y., Wong D.K.H., Seto W.K.W., Lai C.L. and Yuen R.M.F., Estradiol activated microrna 23a directly or synergistically with p53 implicated in sex difference in hepatocellular carcinoma development, 24th Annual Conference of APASL, March 12–15, 2015, Istanbul, Turkey. Hepatology International. 2015, 9 (Suppl 1): S137-8.
Lai C.L., Wong D.K.H., Ip P.C.P., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lee B.P., Cullaro G., Wu C.H., Cheng C.T.K., Yuen J.C.H., Ngai W.S. and Yuen R.M.F., Profound Reduction of HBV Covalently Closed Circular DNA with Long-term Nucleoside/tide Analogue Therapy, Hepatology. 2014, 60, No. 4 (Suppl): 183A.
ZHANG A., Wong D.K.H., Huang F.Y., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Evolutionary changes of hepatitis B virus pre-S mutations prior to development of hepatocellular carcinoma, Poster presentation at the International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2015, 62(Suppl 2): S543.


Researcher : Hui CK
Project Title:Significance of occult hepatitis B infection in patients undergoing autologous HSCT
Investigator(s):Hui CK, Liang RHS, Lau G, Lie AKW
Department:Medicine
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:10/2006




Researcher : Hui KMC
List of Research Outputs

Hui K.M.C., "Sleep Studies: What is the Truth?", Sleep Medicine Conference, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung,Taiwan. 2014.
Lam C.L.D., Tam C.C.T., Lau K.M., Wong W.M., Hui K.M.C., Lam J.C., Wang J.K., Lui M.S.M., Ho J.C.M. and Ip M.S.M., Plasma EGFR Mutation Detection Associated With Survival Outcomes in Advanced-Stage Lung Cancer, Clinical Lung Cancer [Epub ahead of print]. 2015.


Researcher : Hui WM
List of Research Outputs

Lau Y.M., Hui W.M. and Lau C.P., Asystole complicating acalculous cholecystitis, the “Cope's sign” revisited, International Journal of Cardiology. 2015, 182: 447-448.


Researcher : Hui X
Project Title:SIRT1 in perivascular adipose tissues(PVAT) as a mediator of obesity-induced endothelial dysfunction by controlling brown-to-white transition of PVAT: Molecular mechanisms and therapeutic interventions
Investigator(s):Hui X, Vanhoutte PMGR
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2015


List of Research Outputs

Gu P., Hui X., Vanhoutte P.M.G.R., Lam K.S.L. and Xu A., Deletion of SIRT1 in perivascular adipose tissue accelerates obesity-induced endothelial dysfunction , ASCEPT-BPS2015.
Li H., Hui X., Li K., Tang X., Hu X., Xu A. and Wu D., High-level expression, purification and characterization of active human C1q and tumour necrosis factor-related protein-1 in Escherichia coli , Letters in Applied Microbiology. 2014, 59(3): 334-341.
Mao L., Lin W., Nie T., Hui X., Gao X., Li K., Ding M., Tang X., Li P. and Wang Y., Absence of Appl2 sensitizes endotoxin shock through activation of PI3K/Akt pathway, Cell & Bioscience. 2014, 4(1): 60.
Nie T., Hui X., Gao X., Nie B., Mao L., Tang X., Yuan R., Li K., Li P. and Xu A., Conversion of non-adipogenic fibroblasts into adipocytes by a defined hormone mixture, Biochemical Journal. 2015, 467(3): 487-494.


Researcher : Hui YLE
Project Title:Genetic markers of severe diabetic retinopathy in Southern Chinese subjects with type 2 diabetes
Investigator(s):Hui YLE, Lam KSL, Xu A, Wong DSH, Cheung YY, Chan JTJ
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2013


List of Research Outputs

Cheung Y.Y., Hui Y.L.E., Cheung B.M.Y., Woo Y.C., Xu A., Fong H.Y., Ong K.L., Yeung C.Y., Janus E.D., Tse H.F., Sham P.C. and Lam K.S.L., Adiponectin gene variants and the risk of coronary heart disease: a 16-year longitudinal study., Eur J Endocrinol. 2014, 171: 107-115.
Hui Y.L.E., Lee A.C., Lang H.H.B., Chan A.O. and Lam B., Congenital adrenal hyperplasia presenting as a large adrenal incidentaloma in an elderly man, ANZ Journal of Surgery. 2014, Epub ahead of print.
Hui Y.L.E., Yeung C.Y., Lee P.C.H., Woo Y.C., Fong H.Y., Chow W.S., Xu A. and Lam K.S.L., Elevated Circulating Pigment Epithelium-Derived Factor Predicts the Progression of Diabetic Nephropathy in Patients With Type 2 Diabetes, The Journal of Clinical Endocrinology & Metabolism. 2014, 99: E2169-E2177.
Hui Y.L.E., Xu A., Chow W.S., Lee P.C.H., Fong H.Y., Cheung C.W.S., Tse H.F., Chau M.T., Cheung B.M.Y. and Lam K.S.L., Hypoadiponectinemia As an Independent Predictor for the Progression of Carotid Atherosclerosis: A 5-Year Prospective Study, Metabolic Syndrome and Related Disorders. 2014, 12: 517-522.
Lee C.H.P., Hui Y.L.E., Woo Y.C., Yeung C.Y., Chow W.S., Yuen M.A.M., Fong H.Y., Xu A. and Lam K.S.L., Circulating Fibroblast Growth Factor 21 Levels Predict Progressive Kidney Disease in Subjects With Type 2 Diabetes and Normoalbuminuria, The Journal of Clinical Endocrinology & Metabolism. 2015, 100: 1368-1375.
Woo Y.C., Cheung B.M.Y., Yeung C.Y., Lee C.H.P., Hui Y.L.E., Fong H.Y., Tso A.W.K., Tam S. and Lam K.S.L., Cardiometabolic risk profile of participants with prediabetes diagnosed by HbA1c criteria in an urban Hong Kong Chinese population over 40 years of age , Diabetic Medicine. 2015, n/a-n/a.


Researcher : Hung I.F.N.
Project Title:Efficacy and safety of a novel intradermal live-attenuated varicella zoster vaccine in hematopoietic stem cell transplantation donors: a randomized double-blind placebo-controlled trial
Investigator(s):Hung IFN, Lie AKW, Leung AYH, To KKW, Yuen KY
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2013


Project Title:A double blind randomized controlled trial of intradermal hepatitis B vaccination with topical imiquimod in dialyzed patients with chronic renal failure
Investigator(s):Hung IFN, Yuen KY, Tang SCW, To KKW, Yap YHD
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:11/2014


Project Title:Treatment of severe influenza A infection with celecoxib: a double blind randomized controlled trial
Investigator(s):Hung IFN, To KKW, Chan JFW, Chan KH, Yuen KY
Department:Medicine
Source(s) of Funding:Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential
Start Date:12/2014


Project Title:A double-blind randomized controlled trial of 13-valent pneumococcal conjugated vaccine in patients with chronic illness
Investigator(s):Hung IFN, Chan KH
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2015


List of Research Outputs



Researcher : Hung IFN
Project Title:Efficacy and safety of a novel intradermal live-attenuated varicella zoster vaccine in hematopoietic stem cell transplantation donors: a randomized double-blind placebo-controlled trial
Investigator(s):Hung IFN, Lie AKW, Leung AYH, To KKW, Yuen KY
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2013


Project Title:A double blind randomized controlled trial of intradermal hepatitis B vaccination with topical imiquimod in dialyzed patients with chronic renal failure
Investigator(s):Hung IFN, Yuen KY, Tang SCW, To KKW, Yap YHD
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:11/2014


Project Title:Treatment of severe influenza A infection with celecoxib: a double blind randomized controlled trial
Investigator(s):Hung IFN, To KKW, Chan JFW, Chan KH, Yuen KY
Department:Medicine
Source(s) of Funding:Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential
Start Date:12/2014


Project Title:A double-blind randomized controlled trial of 13-valent pneumococcal conjugated vaccine in patients with chronic illness
Investigator(s):Hung IFN, Chan KH
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2015


List of Research Outputs

Chan T.C.I., Hung I.F.N., Chan K.H., Li P.Y., Li T.W., Luk J.K.H., Chu L.W. and Chan H.W.F., A Randomized Controlled Trial to Compare Immunogenicity Between Intramuscular and Intradermal Trivalent Influenza Vaccination in Nursing Home Older Adults, 20th Medical Research Conference, The University of Hong Kong, 17 Jan 2015.. 2015.
Chan T.C.I., Hung I.F.N., Luk J.K.H., Chu L.W. and Chan H.W.F., Comparing Effectiveness Between Intramuscular and Intradermal Trivalent Influenza Vaccination in Nursing Home Residents: A Randomized Controlled Trial, 20th Medical Research Conference, The University of Hong Kong, 17 Jan 2015. (Oral presentation). 2015.
Chan T.C.I., Hung I.F.N., Chan K.H., Li P.Y., Li T.W., Luk J.K.H., Chu L.W. and Chan H.W.F., Local Adverse Effect of Intradermal and Administration of Influenza Vaccination is an Indicator of Satisfactory Immunogenicity, 20th Medical Research Conference 2015, The University of Hong Kong, 17 Jan 2015. . 2015.
Chan T.C.I., Hung I.F.N., Luk J.K.H., Chu L.W. and Chan H.W.F., Prevalence of Influenza Vaccination and Associated Factors Among Chinese Nursing Home Health Care Workers, 20th Medical Research Conference 2015, The University of Hong Kong, 17 Jan 2015.. 2015.
Cheng V.C.C., Chen J.H.K., Poon R.W.S., Lee W.M., So S.Y.C., Wong S.C.Y., Chau P.H., Yip C.Y., Wong S.S.Y., Chan J.F.W., Hung I.F.N., Ho P.L. and Yuen K.Y., Control of hospital endemicity of multiple-drug-resistant Acinetobacter baumannii ST457 with directly observed hand hygiene, European Journal of Clinical Microbiology & Infectious Diseases. 2015, 34: 713-718.
Cheng V.C.C., Chen J.H.K., Tai J.W.M., Wong S.C.Y., Poon W.S.R., Hung I.F.N., Chan J.F.W., Ho P.L., Lo C.M. and Yuen K.Y., Decolonization of gastrointestinal carriage of vancomycin-resistant Enterococcus faecium: case series and review of literature, BMC Infectious Diseases. 2014, 14: 514.
Hung I.F.N., Advances in Infectious Diseases and Management of Common Neurological Problems, 20th Hong Kong Medical Forum, Department of Medicine, The University of Hong Kong, 16 May 2015. (Invited Session Chairman). 2015.
Hung I.F.N., Advances in the Management of Hepatitis C, Hong Kong Pharmacy Conference 2015, The Pharmaceutical Society of Hong Kong, The Practising Pharmacists Association of Hong Kong, The Society of Hospital Pharmacists of Hong Kong, The Department of Pharmacology and Pharmacy of the University of Hong Kong, School of Pharmacy of The Chinese University of Hong Kong, Department of Health and the Hospital Authority, Hong Kong, 29 March 2015. (Invited speaker). 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Best Abstract in Clinical Medicine (Oral) - "Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial", 20th Medical Research Conference 2015, Department of Medicine, The University of Hong Kong . 2015.
Hung I.F.N., Dual Influenza and 23-Valent Pneumococcal Polysaccharide Vaccination Reduces Hospitalization in Chronic Smoker, European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 2015, 25 -28 April, 2015, Copenhagen, Denmark. (Poster presentation). 2015.
Hung I.F.N., Emerging Infectious Diseases, Annual Scientific Meeting 2014, Macau Physician Society, Macau. 14 September 2014. (Invited Speaker). 2014.
Hung I.F.N., Chan K.H., Liang R.H.S., Lai T.S.T. and Yuen K.Y., Harvesting Convalescent Plasma for Hyperimmune Intravenous Globulin Production: A Multicentre Randomized Double-Blind Controlled Trial for Treatment of Patients with Serious S-OIV H1N1 Infection, Health Research Symposium 2014, Hong Kong, 15 Nov 2014. (Poster presentation). 2014.
Hung I.F.N., Helicobacter pylori Infection, The New Challenge., Health Exhibition 2014, Medical Society, Hong Kong University Student Union, Hong Kong. 8 November 2014. (Invited Speaker). 2014.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial, 20th Medical Research Conference, The University of Hong Kong, 17 Jan 2015. (Oral presentation - Best abstract in Clinical Medicine) . 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial, Clinical Infectious Diseases . 2014, 59(9): 1246-55.
Hung I.F.N., Influenza Prevention and Antiviral Stockpile Policy, 2014 Symposium of Influenza and Emerging Pathogens, National Taiwan University, Taipei, Taiwan. 6 December 2014. (Invited speaker). 2014.
Hung I.F.N., Let’s prevent, rather than cure 2014., Adult Vaccine Expert-Input Forum, Hong Kong. 1 August 2014. (Invited Panel Member). 2014.
Hung I.F.N., Practical Tips for OPAT Service Establishment., Outpatient Parenteral Antimicrobial Therapy (OPAT) Workshop, Princess Margaret Hospital, Hong Kong. 4 December 2014. (Invited Moderator). 2014.
Hung I.F.N., Rational Antibiotic Prescribing, Hong Kong Specialist Medical Association, Hong Kong. 5 September 2014. (Invited Speaker). 2014.
Hung I.F.N., Wong D.K.H., Poon R.T.P., Fong D.Y.T., Seto W.K.W., Fung J.Y.Y., Yuen J.C.H., Tiu T.M.R.J., Lai C.L. and Yuen R.M.F., Risk Factors and Post-resection Independent Predictive Score for the Recurrence of Hepatitis B-related Hepatocellular Carcinoma, 20th Medical Research Conference 2015, 17 Jan 2015, The University of Hong Kong, Hong Kong.. 2015.
Hung I.F.N., Liu S.H.K., Tan V.P.Y., Hsu A.S.J., Seto W.K.W., Tong S.M. and Leung W.K., Seven-day Rifabutin Containing Triple Therapy Versus Seven-day Levofloxacin Containing Quadruple Therapy as Second-line Treatment for Helicobacter pylori in Chinese Patients: an Open Label, Randomized Trial, Digestive Disease Week 2015. (Oral presentation). 2015, S149.
Hung I.F.N., The Secret Weapon in Fighting Influenza, CEID 12th Annual Scientific Meeting 2015, The Chinese University of Hong Kong, Hong Kong, 23 June 2015.. 2015.
Hung I.F.N., Unmet needs of pneumonia managemen, Infection Control Associa of Macao (ICAM), Macau, 2014. 29 October 2014. (Invited Speaker). 2014.
Hung I.F.N., Update on Methicillin-resistant Staphylococcus Aureus (MRSA) Infection., Annual Scientific Meeting 2014, Hong Kong Society of Physicians, Hong Kong. 30 November 2014. (Invited Speaker). 2014.
Hung I.F.N., Update on the Management of Helicobacter Pylori Infection , Lecture in Baptist Hospital, Hong Kong, 1 August 2014. 2014.
Hung I.F.N., 「腹瀉︰真假“難辨”」, 3rd Beijing-Hong Kong Infection Physician Forum, Beijing, China. 14 November 2014. (Invited Speaker). 2014.
Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Lau C.Y., Chow W.N., Ngan A.H., To K.K.W., Chan J.F.W., Hung I.F.N., Yam W.C., Yuen K.Y. and Woo P.C.Y., Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics: exploration of potential biomarkers, Emerging Microbes & Infections. 2015, 4: e6.
Lau S.K.P., Lam C.W., Curreem S.O.T., Lee K.C., Lau C.Y., Chow W.N., Ngan A.H., To K.K.W., Chan J.F.W., Hung I.F.N., Yam W.C., Yuen K.Y. and Woo P.C.Y., Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics: exploration of potential biomarkers, Emerging Microbes and Infections. 2015, 4: e6.
Levin Y., Kochba E., Hung I.F.N. and Kenney R., Intradermal Vaccination Using the Novel Microneedle Device MicronJet600: Past, Present, and Future, Human Vaccines & Immunotherapeutics . 2015, 11(4): 991-7.
Li C., Li C., Zhang J., To K.K.W., Lee C.Y., Zhu H., Wu W.L., Chan J.F.W., Chen H., Hung I.F.N., Li L. and Yuen K.Y., Avian Influenza A H7N9 Virus Induces Severe Pneumonia in Mice without Prior Adaptation and Responds to a Combination of Zanamivir and COX-2 Inhibitor , PLoS One. 2014, 9(9): e107966.
Seto W.K.W., Lau E.H.Y., Wu J.T.K., Hung I.F.N., Leung W.K., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., An epidemiological association between the trends of nucleoside analogue prescription and liver cancer incidence from 1999 to 2012 in Hong Kong, China, Poster presentation at the International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2015, 62(Suppl 2): S435.
Tan V.P.Y., Liu S.H.K., Lam Y.F., Hung I.F.N., Yuen R.M.F. and Leung W.K., Rifaximin for the Treatment of Functional Dyspepsia: A Double-Blind Randomized Placebo-Controlled Trial., Digestive Diseases Week 2015.
To K.K.W., Song W., Lau S.Y., Que T.L., Lung D.C., Hung I.F.N., Chen H. and Yuen K.Y., Unique reassortant of influenza A(H7N9) virus associated with severe disease emerging in Hong Kong, Journal of Infection. 2014, 69(1): 60-68.
Wong D.K.H., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Zhang J., Hung I.F.N., Lai C.L. and Yuen R.M.F., Identification of Hepatitis B Virus DNA Polymerase Sequences to Predict Virological Response to Entecavir Therapy, Health Research Symposium 2014, Hong Kong, 15 Nov 2014. (Poster presentation). 2014.
Wong D.K.H., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Hung I.F.N., Young J.L.P., Yuen J.C.H., Ngai W.S., Yuen R.M.F. and Lai C.L., Reduction of hepatitis B core related antigen by long term nucleoside nucleotide analogue therapy and its correlation with intrahepatic HBV DNA reduction, 24th Annual Conference of APASL, March 12–15, 2015, Istanbul, Turkey. Hepatology International. 2015, 9 (Suppl 1): S202.
Wu J.T.K., Lee C.K., Ho P.L., Hung I.F.N., Lin C.K., Lau Y.L., Leung G.M., Cowling B.J. and Peiris J.S.M., A Detailed Longitudinal Study of Infection Attack Rates Among Healthy Adults in Hong Kong During the Epidemic of the Human Swine Influenza A/H1N1 Virus in 2009, Health Research Symposium 2014, Hong Kong, 15 Nov 2014. (Poster presentation). 2014.
Wu J.T.K., Hung I.F.N., Lau Y.L., Peiris J.S.M. and Cowling B.J., A Longitudinal Study of Infection Attack Rates Among Hospital Outpatients in Hong Kong During Epidemic of the Human Swine Influenza A/H1N1 Virus in 2009 by Tracking Temporal Changes in Age-specific Seroprevalence Rates, Health Research Symposium 2014, Hong Kong, 15 Nov 2014. (Poster presentation). 2014.


Researcher : Hwang YYG
List of Research Outputs

Chan C.Y.J., Hwang Y.Y.G., Trendell-Smith N. and Kwong Y.L., Recalcitrant paraneoplastic pemphigus associated with follicular dendritic cell sarcoma: response to prolonged rituximab and ciclosporin therapy., Internal Medicine Journal. 2014, 44(11): 1145-6.
Chan S.Y.T., Hwang Y.Y.G., Singh G.H.H., Cheung C.W.S., Ting A.C.W., Beh S.L., Kwong Y.L. and Tse E.W.C., Increasing incidence of venous thromboembolism due to cancer-associated thrombosis in Hong Kong Chinese, Thrombosis Research. 2014.
Chan T.S., Cheung C.Y., Yeung I.Y., Hwang Y.Y.G., Singh G.H.H., Wong Y.H.I. and Kwong Y.L., Cytomegalovirus retinitis complicating combination therapy with rituximab and fludarabine, Annals of Hematology. 2015.
Hwang Y.Y.G., Mohty M. and Chim J.C.S., Allogeneic hematopoietic stem cell transplantation in Philadelphia-negative adult ALL: myeloablative, non-myeloablative and beyond, Hematology. 2014, Epub ahead of print.
Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Liu S.H.K., Singh G.H.H., Lam Y.F., Fung J.Y.Y., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., A prospective study of hepatitis B reactivation in patients with prior HBV exposure undergoing hematopoietic stem cell transplantation: Reactivation association with graft-versus-host disease, Oral presentation at the International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2015, 62(Suppl 2): S194.
Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Hepatitis B reactivation in patients with prior HBV exposure undergoing rituximab-containing chemotherapy for lymphoma: a prospective study, Journal of Clinical Oncology. 2014, 32(33): 3736-43.
Singh G.H.H., Hwang Y.Y.G., Chan T.S.Y., Chan C.C., Chan C.H.Y., Liu H.S.Y., Mak V., Lin S.Y., Lau C.K., Leung A.Y.H., Lie A.K.W. and Kwong Y.L., Clinicopathologic Features and Outcome of Chinese Patients with Myelofibrosis, 56th ASH Annual Meeting and Exposition, San Francisco, CA.. Blood, 2014, 124 (21).
Singh G.H.H., Chan T.S.Y., Hwang Y.Y.G., Leung A.Y.H., Tse E.W.C. and Kwong Y.L., Clofarabine And High-dose Cytarabine Arabinoside (clara) For Primary Refractory Or Relapsed Acute Myeloid Leukaemia – A Prospective Follow-up Study Of 60 Patients, 20th Congress of the European Haematology Association, Vienna, 11 - 15 June 2015.. 2015.


Researcher : Ip MSM
Project Title:The efficacy of the modified oral appliance in the treatment of mild and moderate obstructive Sleep Apnoea
Investigator(s):Ip MSM
Department:Medicine
Source(s) of Funding:Other Funding Scheme
Start Date:02/1997


Project Title:The effect of oral appliance (OA) in treatment of obstructive sleep apnoea
Investigator(s):Ip MSM, Peh WCG, Cooke MS
Department:Medicine
Source(s) of Funding:Other Funding Scheme
Start Date:06/1997


Project Title:Role of adiponectin in obstructive sleep apnoea
Investigator(s):Ip MSM, Lam KSL
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2002


Project Title:Candidate genes of obstructive sleep apnoea syndrome in Hong Kong Chinese
Investigator(s):Ip MSM, Lam KSL, Song Y, Sham PC
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2005


List of Research Outputs

CUI Y., LIANG Y., Ip M.S.M. and Mak J.C.W., Effects of epigallocatechin gallate on smoke-induced oxidative stress and apoptosis in rat lung in vivo, Respirology. 2015, 20 (Supplement 1): 11.
CUI Y., Ip M.S.M. and Mak J.C.W., The role of serotonin homeostasis in airway oxidative stress and inflammation in airway epithelial cells, Am J Respir Crit Care Med. 2015, 191: A1276.
CUI Y., LIANG Y., Ip M.S.M. and Mak J.C.W., Travel Award - Effects of epigallocatechin gallate on cigarette smoke-induced oxidative stress and apoptosis in rat lung in vivo, Airway Vista 2015. 2015.
Ip M.S.M., CPAP and non-CPAP treatment for OSA, 19th Congress of Asian Pacific Society of Respirology, Bali, Indonesia, Nov 2014. 2014.
Ip M.S.M., Clinical characteristics including cephalogram in SDB, 19th Congress of Asian Pacific Society of Respirology, Bali, Indonesia, Nov 2014. 2014.
Ip M.S.M., Co-chairman, Congress Symposia 3 : OSA - The burden of Disease, 19th Congress of Asian Pacific Society of Respirology, Bali, Indonesia, Nov 2014. 2014.
Ip M.S.M., Co-chairman, Postgraduate Course on Respiratory Neurobiology and Sleep, 19th Congress of Asian Pacific Society of Respirology, Bali, Indonesia, Nov 2014. 2014.
Ip M.S.M., Member of Advisory Board, Sleep and Biological Rhythms. 2014.
Ip M.S.M., Member of Editorial Board, Journal of Thoracic Disease. 2014.
Ip M.S.M., Member of Editorial Board, Sleep Medicine. 2014.
Ip M.S.M., OSA and adiposity - partners in crime (Asian Sleep Forum), 6th World Congress on Sleep Medicine, Seoul, Korea, Mar 2015. 2015.
LIANG Y., LI X., Zhang Y., ZHEN Z., Yeung S.C., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Amelioration of cigarette smoke-induced cardiac dysfunction and inflammation by mesenchymal stem cells, J HK Coll Cardiol. 2014, 22: 49.
LIANG Y., Ip M.S.M. and Mak J.C.W., Epigallocatechin gallate alleviated cigarette smoke-induced cardiac inflammation, Respirology . 2015, 20 (Supplement 1): 11.
LIANG Y., LI X., Zhang Y., ZHEN Z., Yeung S.C., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Outstanding Oral presentation - Amelioration of cigarette smoke-induced cardiac dysfunction and inflammation by mesenchymal stem cells , 18th Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine. 2014.
Lai Y.K.A., Fong D.Y.T., Lam C.M.J., Weaver T.E. and Ip M.S.M., The efficacy of a brief motivational enhancement education program on continuous positive airway pressure adherence in obsrtuctive sleep apnea: a randomized controlled trial, Chest. 2014, 146(3): 600-610.
Lam C.L.D., Lam K.S.L. and Ip M.S.M., Obstructive sleep apnoea, insulin resistance and adipocytokines, Clinical Endocrinology. Wiley, 2014.
Lam C.L.D., Tam C.C.T., Lau K.M., Wong W.M., Hui K.M.C., Lam J.C., Wang J.K., Lui M.S.M., Ho J.C.M. and Ip M.S.M., Plasma EGFR Mutation Detection Associated With Survival Outcomes in Advanced-Stage Lung Cancer, Clinical Lung Cancer [Epub ahead of print]. 2015.
Lau E.Y.Y., Ip M.S.M. and Lee T.M.C., Neurcognitive and psychosocial outcomes of obstructive sleep apnea in Hong Kong Chinese, Hong Kong Medical Journal. 2014, 20(7): 19-23.
Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Intermittent hypoxia-induced adipocyte derived secretory products cause inflammatory responses in endothelial cells in vitro, Eur Respir J. 2014, 44: Suppl. 58, 4447.
Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Intermittent hypoxia-induced adipocyte derived secretory products cause inflammatory responses in endothelial cells in vitro, European Respiratory Society International Congress 2014, Munich, Germany, Sep 2014. Abst. 4447.
Li X., Zhang Y., Yeung S.C., Liang Y., Li X., Ding Y., Ip M.S.M., Tse H.F., Mak J.C.W. and Lian Q., Mitochondrial transfer of induced pluripotent stem cells-derived MSCs to airway epithelial cells attenuates cigarette smoke-induced damage, American Journal of Respiratory Cell and Molecular Biology. 2014, 51(3): 455-465.
Patil N.G., Yip A.L.M. and Ip M.S.M., Pain and joy in implementation of curriculum reform: The University of Hong Kong Medical Faculty Experience, MGM Journal of Medical Sciences. 2015, 2(2): 98-102.
Quanjer P.H., Capderou A., Mazicioglu M.M., Aggarwal A.N., Banik S.D., Popovic S., Tayie F.A., Golshan M.M., Ip M.S.M. and Zelter M., All-age relationship between arm span and height in different ethnic groups, European Respiratory Journal. 2014, 44: 905-912.
WANG Y., Yeung S.C., Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Intermittent hypoxia accelerates adipogenic differentiation in human subcutaneous preadipocytes in vitro, Am J Respir Crit Care Med. 2015, 191: A2704.


Researcher : JIANG N
List of Research Outputs

JIANG N., Yung S.S.Y., Chau K.M., Zhang Q. and Chan D.T.M., Decorin Suppresses Mesothelial Cell Epithelial-to-Mesenchymal Transition, 15th Congress of the International Society for Peritoneal Dialysis. 2014.
Yung S.S.Y., JIANG N., Chau K.M., Zhang Q. and Chan D.T.M., Decorin Ameliorates Peritoneal Fibrosis in Peritoneal Dialysis Related Peritonitis, American Society of Nephrology Kidney Week 2014.


Researcher : Jim MH
List of Research Outputs

Jim M.H., Wong K.L. and Yiu K.H., Angiographic and clinical results of everolimus-eluting stent utilization in saphenous vein graft lesions (ARES)., Int J Cardiol. 2015. 2015, 184: 433-435.
Jim M.H. and Yiu K.H., Combined drug-eluting stent and supplementary paclitaxel-eluting balloon application at side branch ostium for in-stent restenotic true bifurcation lesion., Int J Cardiol.. 2015, 181: 149-151.
Jim M.H., Lee M.K., Fung R.C., Chan A.K., Chan K.T. and Yiu K.H., Six month angiographic result of supplementary paclitaxel-eluting balloon deployment to treat side branch ostium narrowing (SARPEDON)., Int J Cardiol. 2015. 2015, 187: 594-597.


Researcher : Jin Y
Project Title:Cytogenetic and molecular genetic characterization of esophageal carcinomas
Investigator(s):Jin Y, Kwong YL, Tsao GSW
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:10/2002




Researcher : KWOK HM
List of Research Outputs

KWOK H.M., Cheng K.Y., Li F.Y.L., Chan Y.C.C., Hoo R.L.C., Ye D., Xu A. and Lam K.S.L., Inactivation of c-Jun N-terminal Kinase in Adipose Tissue Alleviates Atherosclerosis in Diet-induced Obese ApoE-deficient Mice, 83rd European Atherosclerosis Society Congress. 2015.


Researcher : Kam KM
List of Research Outputs

Chu J.Y.S., Yung S.S.Y., Chau K.M., Kam K.M. and Chan D.T.M., MicroRNA-200c inhibits TGF-β1-induced epithelial-to-mesenchymal transition and fibrogenesis in mesothelial cells, Gordon Research Conference - Fibronectin, Integrins & Related Molecules. 2015.
LI N., Chau K.M., Kam K.M., Chan D.T.M. and Yung S.S.Y., Peritonitis Induces Native and EDA+ Fibronectin Expression in Peritoneal Mesothelial Cells Via TGF-beta1 and PI3K and MAPK Activation, Gordon Research Conference Fibronectin, Integrins & Related Molecules. 2015.


Researcher : Kong BMH
List of Research Outputs

PU D., Yiu E.M.L., Chan K.M.K., Kong B.M.H., Murry T. and Wong M.C.M., Swallowing problems in the elderly: prevalence, impact on quality of life, and carers' knowledge, 2nd Australian and Asia Pacific Laryngology Conference 2014, Laryngology Society of Australasia, Australia, November 7 - 9, 2014.


Researcher : Kong SL
List of Research Outputs

Kong S.L., Lee S.W.L., Lui G.C.S., Chan W.S., Fok A.K.T., Lee H.P. and Wu K.Y.K., VALIDATION OF ACCURACY OF HOME BLOOD PRESSURE MONITORING DEVICES BY BLAND AND ALTMAN LIMITS OF AGREEMENT AND METHOD OF VARIANCE ESTIMATES RECOVERY, Journal of the American College of Cardiology. 2015, 65: A1406.
Lee S.W.L., Lam S.C.C., Kong S.L., Chan K.W.K., Tam C.C., Wong K.L., Wong A.Y.T., Yung A.S.Y., Shea C.P., Zhang L. and Wu K.Y.K., TCT-367 2-Year Sequential OCT Follow-up Findings and 3-Year Clinical Outcomes of the New Dual Therapy Endothelial Progenitor Cell Capturing Sirolimus-eluting COMBO Stent: The EGO-COMBO Study, Journal of the American College of Cardiology. 2014, 64: B107.


Researcher : Kopaniszen M
List of Research Outputs

Fung J.Y.Y., Wong D.K.H., Seto W.K.W., Kopaniszen M., Lai C.L. and Yuen R.M.F., Hepatitis B Surface Antigen Seroclearance: Relationship to Hepatitis B e-Antigen Seroclearance and Hepatitis B e-Antigen-Negative Hepatitis, The American Journal of Gastroenterology. 2014, 109: 1764-1770.
Lai C.L., Wong D.K.H., Ip P.C.P., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lee B.P., Cullaro G., Wu C.H., Cheng C.T.K., Yuen J.C.H., Ngai W.S. and Yuen R.M.F., Profound Reduction of HBV Covalently Closed Circular DNA with Long-term Nucleoside/tide Analogue Therapy, Hepatology. 2014, 60, No. 4 (Suppl): 183A.
Wong D.K.H., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Zhang J., Hung I.F.N., Lai C.L. and Yuen R.M.F., Identification of Hepatitis B Virus DNA Polymerase Sequences to Predict Virological Response to Entecavir Therapy, Health Research Symposium 2014, Hong Kong, 15 Nov 2014. (Poster presentation). 2014.
Wong D.K.H., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Hung I.F.N., Young J.L.P., Yuen J.C.H., Ngai W.S., Yuen R.M.F. and Lai C.L., Reduction of hepatitis B core related antigen by long term nucleoside nucleotide analogue therapy and its correlation with intrahepatic HBV DNA reduction, 24th Annual Conference of APASL, March 12–15, 2015, Istanbul, Turkey. Hepatology International. 2015, 9 (Suppl 1): S202.


Researcher : Kumana CR
List of Research Outputs

Hai J.J., Singh G.H.H., Tse H.F., Kumana C.R., Kwong Y.L. and Siu D.C.W., Torsade de Pointes during oral arsenic trioxide therapy for acute promyelocytic leukemia in a patient with heart failure, Annals of Hematology. 2014.
Kumana C.R., Cheung B.M.Y. and Chan L.S., Airport screening for Ebola: current thermal scanning procedures are unreliable, BMJ. 2014, 349: g6571-g6571.
Yiu K.H., Ng W.S., Chan D., Sit K.Y., Wong A., Lee C.W., Chum H.L., Cheung W.Y., Pun C.T., Ho K.L., CHEN Y., Ho K.M., Kumana C.R., Cheung H.L., Chung M.C., Lau C.P., Au K.W. and Tse H.F., Improved prognosis following renin-angiotensin-aldosterone system blockade in patients undergoing concomitant aortic and mitral valve replacement., Int J Cardiol. 2014. 2014, 177(2): 680-682.


Researcher : Kung AWC
Project Title:Cost-effective osteoporosis intervention thresholds for Hong Kong Southern Chinese postmenopausal women
Investigator(s):Kung AWC, McGhee S
Department:Medicine
Source(s) of Funding:Health and Health Services Research Fund - Full Grants
Start Date:10/2009


List of Research Outputs

Li R.H.W., Cheung C.L., Tan K.C.B., Sham P.C., Kung A.W.C. and Tang G.W.K., Replication study of genetic loci influencing age at menopause in Southern Chinese women., The 10th European Congress on Menopause and Andropause, Madrid, May 2015.
Sing C.W., Lui V.W.Y., Sham P.C., Tan K.C.B., Kung A.W.C., Wong I.C.K., Cheung B.M.Y., Chan J.C.Y. and Cheung C.L., JAG1 Polymorphism is Associated with Incident Neoplasm., 23rd Annual International Genetic Epidemiology Society, Vienna, Aug 2014.


Researcher : Kung MHW
List of Research Outputs

Ho W.L., Pang S.Y.Y., Li M., Tse H.M., Kung M.H.W., Sham P.C. and Ho S.L., PMCA4 (ATP2B4) mutation in familial spastic paraplegia causes delay in intracellular calcium extrusion, Brain and Behavior. 2015, 5: n/a-n/a.
Li M., Ho W.L., Pang S.Y.Y., Tse H.M., Kung M.H.W., Sham P.C. and Ho S.L., PMCA4 (ATP2B4) Mutation in Familial Spastic Paraplegia, PLoS ONE. 2014.


Researcher : Kwan SC
List of Research Outputs

Guo Y., Chung S.K., Siu D.C.W., Kwan S.C., Ho W.L., Yeung P.K.K. and Chan K.H., Endothelin-1 overexpression exacerbate experimental allergic encephalomyelitis, Journal of Neuroimmunology. 2014.
Ng C.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Lam K.S.L., Xu A. and Chan K.H., Adiponectin deficiency induced cognitive dysfunction and Alzheimer’s disease pathogenesis in mice through the disruption of insulin sensitivity and inactivated AMPK signaling , 67th American Academy of Neurology Annual Meeting. 2015.
Ng C.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Lam K.S.L., Xu A. and Chan K.H., Research Travel Scholarship 2015, American Academy of Neruology. 2015.


Researcher : Kwan SKJ
Project Title:Comparing vascular dementia and Alzheimer’s dementia: a preliminary, cross-sectional, multimodal comparative study evaluating clinical and cognitive profile, neuroimaging, biomarkers and quantitative EEG
Investigator(s):Kwan SKJ, Lee TMC, Law ACK, Mak HKF, Cheung RTF, Chang RCC, Lum TYS, Tang SCW
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2015


Project Title:British Geriatrics Society Spring Meeting 2015; Comprehensive Index of Frailty: a multi-dimensional construct from the Hong Kong Centenarian Study/Depression, not lethargy, moderates the frailty-subjective health relationship among centenarians/Frailty, comorbidity, disability and poor self-rated health: prevalence of overlaps amongst the oldest-old adults from the Hong Kong Centenarian Study/Depressive symptoms predict memory decline over subsequent 4 years: longitudinal analysis of the Guangzhou Biobank Cohort Study
Investigator(s):Kwan SKJ
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:04/2015
Completion Date:05/2015


List of Research Outputs

Kwan S.K.J., Advances in vascular cognitive impairment, International Alzheimer’s Disease Conference 2015 (HKU). 2015.
Kwan S.K.J., Association between Infection and Vaccination and Cardiovascular Risks, 6th Master Class on Ageing in Asia (Taipei Veterans General Hospital, Taiwan). 2015.
Kwan S.K.J., Chu L.W., Chan H.W.F., Lee T.M.C., Law A.C.K., Mak H.K.F., Cheung R.T.F., Chang R.C.C., Lum T.Y.S. and Tang S.C.W., Comparing vascular dementia and Alzheimer’s dementia: a preliminary, cross-sectional, multimodal comparative study evaluating clinical and cognitive profile, neuroimaging, biomarkers and quantitative EEG ($240,000), Seed Funding HKU. 2014.
Kwan S.K.J., Tang Y.M.J., Wong G.H.Y., Chang R.C.C. and Lum T.Y.S., Comparison of characteristics of people with subjective cognitive impairment vs. mild cognitive impairment vs. dementia: cross-sectional data from the Hong Kong Alzheimer’s Disease Association, International Alzheimer’s Disease Conference 2015 (HKU). 2015.
Kwan S.K.J., LAU H.P. and Cheung K.S.L., Comprehensive Index of Frailty: a multi-dimensional construct from the Hong Kong Centenarian Study, 20th Medical Research Conference (HKU). 2015.
Kwan S.K.J., LAU H.P. and Cheung K.S.L., Comprehensive Index of Frailty: a multi-dimensional construct from the Hong Kong Centenarian Study, British Geriatrics Society Spring Meeting 2015 (Nottingham, UK). 2015.
Kwan S.K.J., LAU H.P. and Cheung K.S.L., Comprehensive Index of Frailty: a multi-dimensional construct from the Hong Kong Centenarian Study, Hong Kong Medical Journal. 2015, 21(1 Suppl 1): 11.
Kwan S.K.J., LAU H.P., Martin P. and Cheung K.S.L., Depression, not lethargy, moderates the frailty-subjective health relationship among centenarians., British Geriatrics Society Spring Meeting (Nottingham, UK). 2015.
Kwan S.K.J., Dr Ng Ngai-sing Prize For Outstanding Free Paper Presentation (Annual Scientific Meeting 2015), Hong Kong Geriatrics Society. 2015.
Kwan S.K.J., Editorial Board Member, Palliative Medicine and Hospice Care - Open Journal. Openventio Publishers, 2014.
Kwan S.K.J., Ethical Challenges In Geriatric Care, Symposium on Supporting Patient Autonomy in Old Age and Death (Centre for Medical Ethics and Law, The University of Hong Kong). 2015.
Kwan S.K.J., LAU H.P. and Cheung K.S.L., Frailty, comorbidity, disability and poor self-rated health: prevalence of overlaps amongst the oldest-old adults from the Hong Kong Centenarian Study., British Geriatrics Society Spring Meeting (Nottingham, UK). 2015.
Kwan S.K.J., Health Care Services for Older People in Hong Kong and United Kingdom, 英國與香港高齡民眾健康照護體系發展現況, International Conference for Integrated Care in Aging Societies (Kaohsiung Veterans General Hospital, Taiwan). 2014.
Kwan S.K.J., Tsang J.W.H., Chan F.H.W. and Yau S.Z.M., Humanism in Aging: Intergenerational and Experiential Learning in the Community ($100,000), Development Fund for Medical Humanities, LKS Faculty of Medicine (HKU). 2015.
Kwan S.K.J., Humanism in Aging: Using Empathy and Compassion to Make Life Better in Old Age, 3rd International Symposium on Communication in Healthcare (Polytechnic University, HK). 2015.
Kwan S.K.J., Influence of antithrombotic medications on cerebrovascular abnormalities on MRI (microbleeds and white matter ischemia) in patients with and without atrial fibrillation (AF) ($50,000), Boehringer Ingelheim (HK) Ltd. . 2014.
Kwan S.K.J., Maximizing the Impact of Your Presentation, Advanced Teaching Course, The University of Hong Kong. 2014.
Kwan S.K.J., Tang Y.M.J., Wong G.H.Y., Chang R.C.C. and Lum T.Y.S., Outstanding Investigator Award (1st Runner Up), International Alzheimer’s Disease Conference 2015 (HKU). 2015.
Kwan S.K.J., Leung A.Y.M., Kwan C.W., Lai C.K.Y., Bai X., Chong A.M.L., Liu J., Lou V.W. and Chi I., Prevalence and risk factors for the use of physical and chemical restraints amongst older people living in residential care: data from the Hong Kong Longitudinal Study on Long-Term Care Facility Residents (Platform Presentation), Hong Kong Geriatrics Society Annual Scientific Meeting 2015.
Kwan S.K.J., Psycho-Cognitive Sequelae of Stroke, 10th International Symposium on Healthy Aging (Hong Kong). 2015.
Kwan S.K.J., Stoke thrombolysis, Education Meeting on Stroke Medicine, HKU-Shenzhen Hospital (Shenzhen, China). 2015.
Kwan S.K.J., LAU H.P. and Cheung K.S.L., Toward a Comprehensive Model of Frailty: An Emerging Concept From the Hong Kong Centenarian Study, Journal of the American Medical Directors Association. 2015.
Lau G.K.K., Chan L.K., Li O.Y., Yuen T.K., Wong Y.K., Chan K.H., Chan J.F.W., Chang S.K.R., Cheung R.T.F., Doherty I., Ho S.L., Hon F.K.S., Kwan S.K.J., Lee R., Leung G.K.K., Mak W., Mak H.K.F., Shih K.C. and Tsang C.O.A., Establishing an eLearning Platform in Clinical Neurosciences, East-West Alliance Global Symposia 2014.
Lau G.K.K., Chan L.K., Chan K.H., Chang S.K.R., Chang R.C.C., Cheung R.T.F., Doherty I., Ho S.L., Hon S.F.K., Kwan S.K.J., Lee R., Leung G.K.K., Mak W., Shih K.C. and Tsang C.O.A., ePoster Award (First Prize), Title: Establishing an eLearning Platform in Clinical Neurosciences at HKU, HKU Li Ka Shing Faculty of Medicine Frontiers Series – East-West Alliance Global Symposia. 2014.
Leung D.Y.P., Lo S.K.L., Leung A.Y.M., Lou V.W., Chong A.M.L., Kwan S.K.J., Chan W.C.H. and Chi I., Prevalence and risk factors of potential elder abuse in Hong Kong, International Association of Geriatrics & Gerontology (IAGG, Dublin). 2015.
Leung D.Y.P., Lo S.K.L., Leung A.Y.M., Lou V.W., Chong A.M.L., Kwan S.K.J., Chan W.C.H. and Chi I., Prevalence and risk factors of potential elder abuse in Hong Kong, Irish Ageing Studies Review. 2015, 6(1): 299.
Price M., Günther A. and Kwan S.K.J., Antiepileptic drugs for the primary and secondary prevention of seizures after intracranial venous thrombosis, In: The Cochrane Collaboration, Cochrane Database of Systematic Reviews: Reviews. Chichester, UK, John Wiley & Sons, Ltd, 2014.
Shea Y.F., Mok W.W.Y., Chan J.F.W. and Kwan S.K.J., A Hidden Cause of Recurrent Asthmatic Attacks, Journal of the American Geriatrics Society. 2014, 62: 1408-1409.
Shea Y.F., Chu L.W., Chan A.O.K. and Kwan S.K.J., Delayed diagnosis of an old Chinese woman with familial Alzheimer's disease, Journal of the Formosan Medical Association. 2015.
Shea Y.F., Chan T.C., Chang R.S.K., Hon F.K.S., Kwan S.K.J. and Chu L.W., Rapidly Progressive Ataxia During Rehabilitation and a Difficult Road to Diagnosis, Journal of the American Geriatrics Society. 2014, 62: 1609-1610.
Xu L., Kwan S.K.J., Jiang C.Q., Zhang W.S., Cheng K.K. and Lam T.H., Depressive symptoms predict memory decline over subsequent 4 years, and vice versa: longitudinal analysis of the Guangzhou Biobank Cohort Study (Platform Presentation), British Geriatrics Society Spring Meeting (Nottingham, UK). 2015.


Researcher : Kwong YL
Project Title:Provision of purine analogues for the treatment of patients with chronic lymphoid malignancies
Investigator(s):Kwong YL, Liang RHS
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:07/1997


Project Title:Molecular mechanisms and consequences of downregulation of p73 in natural killer cell lymphoma
Investigator(s):Kwong YL
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2002


Project Title:Molecular basis of arsenic resistance in tumours
Investigator(s):Kwong YL, Tse EWC
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2003


Project Title:Provision of free cytogenetic and molecular testing for monitoring of disease relapse after bone marrow transplantation
Investigator(s):Kwong YL, Liang RHS, Lie AKW, Au WY
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:11/2004


Project Title:Provision of ibritumomab for the treatment of lymphoma
Investigator(s):Kwong YL, Liu KY
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2008


Project Title:Provision of oral arsenic trioxide free to patients with cancers
Investigator(s):Kwong YL, Au WY, Chim JCS
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2008


Project Title:Provision of ibritumomab for the treatment of Iymphoma
Investigator(s):Kwong YL, Liu KY
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:05/2010


Project Title:Provision of clofarabine for the treatment of relapsed or refractory acute leukaemia
Investigator(s):Kwong YL, Leung AYH, Tse EWC
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:08/2010


Project Title:Provision of bendamustine for the treatment of non-Hodgkin lymphoma and chronic lymphocytic leukemia
Investigator(s):Kwong YL, Leung AYH, Tse EWC
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:10/2012


Project Title:Provision of free azacitidine for high-risk patient with myelodysplastic syndrome (MDS)
Investigator(s):Kwong YL, Leung AYH
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2014


List of Research Outputs

Au Yeung K.H.R., Chen W.Y.W., Guo T., Wong K.Y., Shimizu N., Tsuchiyama J., Loong F., Kwong Y.L. and Srivastava G., Receptor-type tyrosine-protein phosphatase kappa promoter hypermethylation correlates with unfavorable prognosis in nasal NK/T-cell lymphoma patients treated with SMILE regimen, The 60th Autumn Annual Meeting of the Japanese Society of Pathology. 第60回日本病理学会秋期特別総会, Japan, 2014.
Chan C.Y.J., Hwang Y.Y.G., Trendell-Smith N. and Kwong Y.L., Recalcitrant paraneoplastic pemphigus associated with follicular dendritic cell sarcoma: response to prolonged rituximab and ciclosporin therapy., Internal Medicine Journal. 2014, 44(11): 1145-6.
Chan C.Y.J., Trendell-Smith N.J., So J.C.C. and Kwong Y.L., Subtle skin involvement in nodal γδ peripheral T-cell lymphoma, The Journal of Dermatology. 2015, 42: 328-330.
Chan S.Y.T., Hwang Y.Y.G., Singh G.H.H., Cheung C.W.S., Ting A.C.W., Beh S.L., Kwong Y.L. and Tse E.W.C., Increasing incidence of venous thromboembolism due to cancer-associated thrombosis in Hong Kong Chinese, Thrombosis Research. 2014.
Chan T.S., Cheung C.Y., Yeung I.Y., Hwang Y.Y.G., Singh G.H.H., Wong Y.H.I. and Kwong Y.L., Cytomegalovirus retinitis complicating combination therapy with rituximab and fludarabine, Annals of Hematology. 2015.
Chen W.Y.W., Guo T., Shen L., Wong K.Y., Tao Q., Choi W.L., Au Yeung K.H.R., Chan Y.P., Wong M.L.Y., Tang J.C.O., Liu W.P., Li G.D., Shimizu N., Loong F., Tse E.W.C., Kwong Y.L. and Srivastava G., Receptor-type tyrosine-protein phosphatase k directly targets STAT3 activation for tumor suppression in nasal NK/T-cell lymphoma, Blood. United States of America, The American Society of Hematology, 2015, 125(10): 1589-600.
Cheung C.Y., Tam S., Lam C.W., Lie A.K.W. and Kwong Y.L., Allogeneic haematopoietic stem cell transplantation for erythropoietic protoporphyria: A cautionary note, Blood Cells, Molecules, and Diseases. 2015, 54: 266-267.
Chim J.C.S., Sim P.Y.J., Tam S., Tse E.W.C., Lie A.K.W. and Kwong Y.L., LDH is an adverse prognostic factor independent of ISS in transplant-eligible myeloma patients receiving bortezomib-based induction regimens, European Journal of Haematology. 2014, n/a-n/a.
Chiu W.Y.J., Serra S., Kamel-Reid S., Zhang T., McNamara M.G., Bedard P.L., Hedley D., Moore M., Dhani N.C., Shek T.W.H., Kwong Y.L., Yau T.C.C., Doherty M. and Knox J.J., Next generation sequencing: profiling gallbladder cancer, Gastrointestinal Cancers Symposium 2015.
Hai J.J., Singh G.H.H., Tse H.F., Kumana C.R., Kwong Y.L. and Siu D.C.W., Torsade de Pointes during oral arsenic trioxide therapy for acute promyelocytic leukemia in a patient with heart failure, Annals of Hematology. 2014.
Santoso T., Siu D.C.W., Irawan C., Chan W.S., Alwi I., Yiu K.H., Aziz A., Kwong Y.L. and Tse H.F., Endomyocardial Implantation of Autologous Bone Marrow Mononuclear Cells in Advanced Ischemic Heart Failure: a Randomized Placebo-Controlled Trial (END-HF)., J Cardiovasc Transl Res. 2014.
Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Liu S.H.K., Singh G.H.H., Lam Y.F., Fung J.Y.Y., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., A prospective study of hepatitis B reactivation in patients with prior HBV exposure undergoing hematopoietic stem cell transplantation: Reactivation association with graft-versus-host disease, Oral presentation at the International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2015, 62(Suppl 2): S194.
Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Hepatitis B reactivation in patients with prior HBV exposure undergoing rituximab-containing chemotherapy for lymphoma: a prospective study, Journal of Clinical Oncology. 2014, 32(33): 3736-43.
Singh G.H.H., Man C.H., Ip H.W., Choi W.L., Chow H.C.H., Kwong Y.L. and Leung A.Y.H., Azacitidine as post-remission consolidation for sorafenib-induced remission of Fms-Like Tyrosine Kinase-3 internal tandem duplication positive acute myeloid leukemia, Haematologica. 2015.
Singh G.H.H., Hwang Y.Y.G., Chan T.S.Y., Chan C.C., Chan C.H.Y., Liu H.S.Y., Mak V., Lin S.Y., Lau C.K., Leung A.Y.H., Lie A.K.W. and Kwong Y.L., Clinicopathologic Features and Outcome of Chinese Patients with Myelofibrosis, 56th ASH Annual Meeting and Exposition, San Francisco, CA.. Blood, 2014, 124 (21).
Singh G.H.H., Chan T.S.Y., Hwang Y.Y.G., Leung A.Y.H., Tse E.W.C. and Kwong Y.L., Clofarabine And High-dose Cytarabine Arabinoside (clara) For Primary Refractory Or Relapsed Acute Myeloid Leukaemia – A Prospective Follow-up Study Of 60 Patients, 20th Congress of the European Haematology Association, Vienna, 11 - 15 June 2015.. 2015.
Singh G.H.H., Ip H.W., Pang A.W.K., Sum C.Y., Leung A.Y.H. and Kwong Y.L., FLT3 internal tandem duplication in acute promyelocytic leukemia: central nervous system relapse, Annals of Hematology. 2014.
Singh G.H.H., Au W.Y., Cheung W.W., Lee E.Y.P. and Kwong Y.L., Oral arsenic trioxide-based regimen as salvage treatment for relapsed or refractory mantle cell lymphoma, Annals of Oncology. 2014, 25: 1391-1397.
Singh G.H.H., Leung A.Y.H., Tse E.W.C. and Kwong Y.L., Relapse Characteristics And Risk Factors For Central Nervous System Involvement In Acute Promyelocytic Leukaemia In The Oral Arsenic Trioxide Era – A 13-year Follow-up Study, 20th Congress of the European Haematology Association, Vienna, June 11 - 15, 2015.. Haematologica, 2015.
So J.C.C., Chan K.H., Pang A.W.K., Chan J.K.F. and Kwong Y.L., Diganosis of brainstem involvement in NK/T cell lymphoma, Annals of Hematology. 2014, 93: 1433.
Tse E.W.C., Chan S.Y.T., Koh L.P., Chng W.J., Kim W.S., Tang T., Lim S.T., Lie A.K.W. and Kwong Y.L., Allogeneic haematopoietic SCT for natural killer/T-cell lymphoma: a multicentre analysis from the Asia Lymphoma Study Group, Bone Marrow Transplantation. 2014, 49: 902-906.
Tse E.W.C. and Kwong Y.L., Epstein Barr virus-associated lymphoproliferative diseases: the virus as a therapeutic target, Experimental & Molecular Medicine. 2015, 47: e136.
Tse E.W.C. and Kwong Y.L., T-cell lymphoma: Microenvironment-related biomarkers, Seminars in Cancer Biology. 2015.
Wong H., Hwang Y.Y., Leung R.Y.Y., Chan G.S.W., Khong P.L. and Kwong Y.L., Unilateral hearing loss due to lymphocytosis and a contralateral putamen lesion, Annals of Hematology. 2015, 94: 703-704.
YIM L.H.R., Wong K.Y., Kwong Y.L., Loong F., Leung C.Y., Chu R., Lam W.W., Hui P.K., Lai R. and Chim J.C.S., Methylation of miR-155-3p in mantle cell and other non-Hodgkin's lymphoma, Oncotarget. 2014, in press.


Researcher : LAM PSM
List of Research Outputs

SAMARANAYAKE N.R., Cheung D.S., LAM P.S.M., Cheung T.T., Chui W.C., Wong I.C. and Cheung B.M.Y., The effectiveness of a 'Do Not Use' list and perceptions of healthcare professionals on error-prone abbreviations. Epub ahead of print, Int J Clin Pharm. 2014.


Researcher : LAW CY
List of Research Outputs

Ng K.M., LAW C.Y. and Tse H.F., Clinical Potentials of Cardiomyocytes Derived from Patient-Specific Induced Pluripotent Stem Cells, In: Prof. Jane Grant-Kels, Journal of Clinical Medicine. MDPI AG, Basel, Switzerland, 2014, 3: 1105-1123.


Researcher : LEE THJ
List of Research Outputs

Pan K., LEE T.H.J., HUANG Z. and Wong C.M., Coupling and Coordination in Gene Expression Processes with Pre-mRNA Splicing, International Journal of Molecular Sciences. 2015, 16(3): 5682-5696.
Wong C.M., WANG Y., LEE T.H.J., HUANG Z., Wu D., Xu A. and Lam K.S.L., Adropin is a brain membrane-bound protein regulating physical activity via NB-3/Notch signaling pathway in mice, The Journal of Biological Chemistry. 2014.
Wong C.M., Pan K., HUANG Z. and LEE T.H.J., Current perspectives on the role of TRAMP in nuclear RNA surveillance and quality control, Research and Reports in Biochemistry. 2015, 5: 111-117.


Researcher : LEUNG LL
List of Research Outputs

LEUNG L.L., Lam S.K. and Ho J.C.M., Arsenic trioxide Suppresses Tumour Growth in Squamous Cell Lung Carcinoma , 20th Medical Research Conference. Hong Kong Medical Journal, 2015, 21: 53.
LI Y., Lam S.K., ZHENG C., LEUNG L.L. and Ho J.C.M., The effect of tumor microenvironment on autophagy and sensitivity to targeted therapy in EGFR-mutated lung adenocarcinoma , 21st Hong Kong International Cancer Congress. 2014.
Lam S.K., LI Y., ZHENG C., LEUNG L.L. and Ho J.C.M., Combination Effect of Arsenic Trioxide and FGFR Inhibitor through Downregulation of FGFR, Akt and Erk in Squamous Cell Lung Carcinoma, 21st Hong Kong International Cancer Congress. 2014.
Lam S.K., LI Y., ZHENG C., LEUNG L.L. and Ho J.C.M., E2F1 Downregulation by Arsenic Trioxide in Lung Adenocarcinoma, International Journal of Oncology. 2014, 45: 2033-43.
Lam S.K., LEUNG L.L. and Ho J.C.M., Massive degradation in FGFR/Akt/Erk signaling by arsenic trioxide and FGFR inhibitor PD173074 in squamous cell lung carcinoma SK-MES-1, 20th Medical Research Conference. Hong Kong Medical Journal, 2015, 21: 30.
ZHENG C., Lam S.K., LI Y., LEUNG L.L. and Ho J.C.M., Arsenic trioxide-induced cytotoxicity in small cell lung cancer via altered redox homeostasis and mitochondrial integrity , 21st Hong Kong International Cancer Congress. 2014.


Researcher : LI A
List of Research Outputs

Yau S.Y., LI A., Xu A. and So K.F., Fat cell-secreted adiponectin mediates physical exercise-induced hippocampal neurogenesis: an alternative anti-depressive treatment?, Neural Regeneration Research. 2015.
Yau S.Y., LI A., Hoo R.L.C., Ching Y.P., Christie B... .R..., Lee T.M.C., Xu A. and So K.F., Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin, Proceedings of the National Academy of Sciences. United States of America, Proceedings of the National Academy of Sciences of the US, 2014, 111: 15810-15815.


Researcher : LI N
List of Research Outputs

LI N., Chau K.M., Kam K.M., Chan D.T.M. and Yung S.S.Y., Peritonitis Induces Native and EDA+ Fibronectin Expression in Peritoneal Mesothelial Cells Via TGF-beta1 and PI3K and MAPK Activation, Gordon Research Conference Fibronectin, Integrins & Related Molecules. 2015.


Researcher : LI R
List of Research Outputs

LI R., Yiu W.H., Wu H., LIN M., WONG W.L.D., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., BMP7 Reduces Tubular Inflammation and Oxidative Stress in Diabetic Nephropathy, J Am Soc Nephrol. 2014, 25: 216A.
LI R., Yiu W.H., Wu H., WONG W.L.D., Chan Y.Y., LIN M., Leung J.C.K., Lai K.N. and Tang S.C.W., BMP7 reduces inflammation and oxidative stress in diabetic tubulopathy, Clinical Science [IF 5.629]. 2015, 128(4): 269-280.
LI R., Yiu W.H. and Tang S.C.W., Role of bone morphogenetic protein-7 in renal fibrosis, Frontiers Physiology [IF 3.534]. 2015, 6: 114.


Researcher : LI X
List of Research Outputs

LI X., Michaeloudes C., Zhang Y., Lian Q., Mak J.C.W., Bhavsar P.K. and Chung K., Oxidative stress-induced mitochondria alteration in human airway smooth muscle cells and mesenchymal stem cells, Am J Respir Crit Care Med. 2015, 191: A5544.
LIANG Y., LI X., Zhang Y., Lian Q. and Mak J.C.W., Amelioration of cigarette smoke-induced cardiac dysfunction and inflammation by mesenchymal stem cells., The 18th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, Hong Kong, 1 November 2014. In Journal of the Hong Kong College of Cardiology, 2014, v. 22 n. 2, p. 49, abstract no. OP2. 2014.
LIANG Y., LI X., Zhang Y., ZHEN Z., Yeung S.C., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Amelioration of cigarette smoke-induced cardiac dysfunction and inflammation by mesenchymal stem cells, J HK Coll Cardiol. 2014, 22: 49.
LIANG Y., LI X., Zhang Y., ZHEN Z., Yeung S.C., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Outstanding Oral presentation - Amelioration of cigarette smoke-induced cardiac dysfunction and inflammation by mesenchymal stem cells , 18th Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine. 2014.
Li X., Zhang Y., Yeung S.C., Liang Y., Li X., Ding Y., Ip M.S.M., Tse H.F., Mak J.C.W. and Lian Q., Mitochondrial transfer of induced pluripotent stem cells-derived MSCs to airway epithelial cells attenuates cigarette smoke-induced damage, American Journal of Respiratory Cell and Molecular Biology. 2014, 51(3): 455-465.
WANG B., Cheng K.Y., Li X., Lam K.S.L. and Xu A., Hypothalamic APPL2 combats against obesity by promoting adaptive thermogenesis in white adipose tissues, EMBL Symposium: Translating Diabetes.. 2015.
WANG B., Cheng K.Y., Li X., Li A., Lam K.S.L. and Xu A., The Role of Hypothalamic APPL2 in Regulation of Energy Expenditure in Adipose Tissues, 2015 Asia Pacific obesity and diabetes symposium.. 2015.
WANG B., Cheng K.Y., Li X., Li A., Lam K.S.L. and Xu A., The hypothalamic APPL2 as a novel regulator of energy homeostasis in adipose tissues, The 10th International Symposium on Healthy Aging 2015. A Decade of Positive Aging. 2015.. 2015.
Zhang Y., LIANG X., Liao S., Wang W., Wang J.J., LI X., Ding Y., LIANG Y., GAO F., Yang M., Fu Q., Xu A., Chai Y.H., He J., Tse H.F. and Lian Q., Potent Paracrine Effects of human induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Attenuate Doxorubicin-induced Cardiomyopathy, Scientific Reports. 2015, 5: 11235.


Researcher : LI Y
List of Research Outputs

LI Y., Lam S.K., ZHENG C., LEUNG L.L. and Ho J.C.M., The effect of tumor microenvironment on autophagy and sensitivity to targeted therapy in EGFR-mutated lung adenocarcinoma , 21st Hong Kong International Cancer Congress. 2014.
Lam S.K., LI Y., ZHENG C., LEUNG L.L. and Ho J.C.M., Combination Effect of Arsenic Trioxide and FGFR Inhibitor through Downregulation of FGFR, Akt and Erk in Squamous Cell Lung Carcinoma, 21st Hong Kong International Cancer Congress. 2014.
Lam S.K., LI Y., ZHENG C. and Ho J.C.M., Downregulation of Thymidylate Synthase and E2F1 by Arsenic Trioxide in Mesothelioma , Work Injury Prevention and Rehabilitation 2014.
Lam S.K., LI Y., ZHENG C. and Ho J.C.M., Downregulation of thymidylate synthase and E2F1 by arsenic trioxide in mesothelioma., International journal of oncology. 2014, 46: 113-22.
Lam S.K., LI Y., ZHENG C., LEUNG L.L. and Ho J.C.M., E2F1 Downregulation by Arsenic Trioxide in Lung Adenocarcinoma, International Journal of Oncology. 2014, 45: 2033-43.
ZHENG C., Lam S.K., LI Y., LEUNG L.L. and Ho J.C.M., Arsenic trioxide-induced cytotoxicity in small cell lung cancer via altered redox homeostasis and mitochondrial integrity , 21st Hong Kong International Cancer Congress. 2014.
ZHENG C., Lam S.K., LI Y. and Ho J.C.M., Arsenic trioxide-induced cytotoxicity in small cell lung cancer via altered redox homeostasis and mitochondrial integrity., International journal of oncology. 2014, 46: 1067-1078.


Researcher : LIANG X
List of Research Outputs

Liang X., Ding Y., Zhang Y., Chai Y.H., He J., Chiu S., GAO F., Tse H.F. and Lian Q., Activation of NRG1-ERBB4 signaling potentiates mesenchymal stem cell-mediated myocardial repairs following myocardial infarction, Cell Death and Disease. 2015, 6: e1765.
Zhang Y., LIANG X., Liao S., Wang W., Wang J.J., LI X., Ding Y., LIANG Y., GAO F., Yang M., Fu Q., Xu A., Chai Y.H., He J., Tse H.F. and Lian Q., Potent Paracrine Effects of human induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Attenuate Doxorubicin-induced Cardiomyopathy, Scientific Reports. 2015, 5: 11235.


Researcher : LIANG Y
List of Research Outputs

CUI Y., LIANG Y., Ip M.S.M. and Mak J.C.W., Effects of epigallocatechin gallate on smoke-induced oxidative stress and apoptosis in rat lung in vivo, Respirology. 2015, 20 (Supplement 1): 11.
CUI Y., LIANG Y., Ip M.S.M. and Mak J.C.W., Travel Award - Effects of epigallocatechin gallate on cigarette smoke-induced oxidative stress and apoptosis in rat lung in vivo, Airway Vista 2015. 2015.
LIANG Y., LI X., Zhang Y., Lian Q. and Mak J.C.W., Amelioration of cigarette smoke-induced cardiac dysfunction and inflammation by mesenchymal stem cells., The 18th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, Hong Kong, 1 November 2014. In Journal of the Hong Kong College of Cardiology, 2014, v. 22 n. 2, p. 49, abstract no. OP2. 2014.
LIANG Y., LI X., Zhang Y., ZHEN Z., Yeung S.C., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Amelioration of cigarette smoke-induced cardiac dysfunction and inflammation by mesenchymal stem cells, J HK Coll Cardiol. 2014, 22: 49.
LIANG Y., Ip M.S.M. and Mak J.C.W., Epigallocatechin gallate alleviated cigarette smoke-induced cardiac inflammation, Respirology . 2015, 20 (Supplement 1): 11.
LIANG Y., LI X., Zhang Y., ZHEN Z., Yeung S.C., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Outstanding Oral presentation - Amelioration of cigarette smoke-induced cardiac dysfunction and inflammation by mesenchymal stem cells , 18th Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine. 2014.
Li X., Zhang Y., Yeung S.C., Liang Y., Li X., Ding Y., Ip M.S.M., Tse H.F., Mak J.C.W. and Lian Q., Mitochondrial transfer of induced pluripotent stem cells-derived MSCs to airway epithelial cells attenuates cigarette smoke-induced damage, American Journal of Respiratory Cell and Molecular Biology. 2014, 51(3): 455-465.
Zhang Y., LIANG X., Liao S., Wang W., Wang J.J., LI X., Ding Y., LIANG Y., GAO F., Yang M., Fu Q., Xu A., Chai Y.H., He J., Tse H.F. and Lian Q., Potent Paracrine Effects of human induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Attenuate Doxorubicin-induced Cardiomyopathy, Scientific Reports. 2015, 5: 11235.


Researcher : LIN M
List of Research Outputs

LI R., Yiu W.H., Wu H., LIN M., WONG W.L.D., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., BMP7 Reduces Tubular Inflammation and Oxidative Stress in Diabetic Nephropathy, J Am Soc Nephrol. 2014, 25: 216A.
LI R., Yiu W.H., Wu H., WONG W.L.D., Chan Y.Y., LIN M., Leung J.C.K., Lai K.N. and Tang S.C.W., BMP7 reduces inflammation and oxidative stress in diabetic tubulopathy, Clinical Science [IF 5.629]. 2015, 128(4): 269-280.
Tang S.C.W., Yiu W.H., LIN M. and Lai K.N., Diabetic Nephropathy and Proximal Damage, Journal of Renal Nutrition [IF 2.548]. 2015, 25(2): 230-233.
Yiu W.H., LIN M. and Tang S.C.W., Toll-like receptor activation: from renal inflammation to fibrosis, Kidney International Supplements. 2014, 4(1): 20-25.


Researcher : LUK TW
List of Research Outputs

WU H., Lo Y., LUK T.W., Lau C.S., Lu L.W. and Mok T.M.Y., Alternatively activated dendritic cells derived from systemic lupus erythematosus patients have tolerogenic phenotype and function.European League of Association of Rheumatology (EULAR) 2015 Annals of the Rheumatic Diseases 2015; 74(Suppl2), 2015, 74(Suppl2): 951.
WU H., Lo Y., LUK T.W., Lau C.S., Lu L. and Mok T.M.Y., Alternatively activated dendritic cells derived from systemic lupus erythematosus patients have tolerogenic phenotype and function, Hong Kong Medical Journal 2015;21:p55 (Abstract 90) . 2015.
WU H., Lo Y., LUK T.W., Chan W.K. and Mok T.M.Y., Bone marrow derived dendritic cells modified by lentiviral-mediated RelB shRNA possess tolerogenic phenotype and functions on lupus splenic lymphocytes. European League of Association of Rheumatology (EULAR) 2015. Ann Rheum Dis 2015; 74(Suppl2), 2015, 74(Suppl2): 951.


Researcher : LUO Y
List of Research Outputs

LUO Y., Sit A.K., Sihoe D.L.A., Suen W.S., Au T.W.K., Tang X., Ma E.S.K., Chan W.K., Wistuba I.I., Minna J.D., Tsao G.S.W. and Lam C.L.D., Aberrant large tumor suppressor 2 (LATS2) gene expression correlates with EGFR mutation and survival in lung adenocarcinomas, Lung Cancer. Elsevier, 2014, 85 (2): 282 - 292.


Researcher : Lai CL
Project Title:A preliminary assessment of safety and antiviral activity of open-label entecavir plus lamivudine therapy in subjects with chronic hepatitis B who have viremia on monotherapy in other entecavir trials
Investigator(s):Lai CL, Yuen RMF
Department:Medicine
Source(s) of Funding:Bristol-Myers-Squibb (HK) - General Award
Start Date:01/2003


Project Title:Long-term assessment of treatment outcomes with entecavir and lamivudine for chronic hepatitis B infection in patients who have enrolled in phase iii entecavir trials
Investigator(s):Lai CL, Yuen RMF
Department:Medicine
Source(s) of Funding:Bristol-Myers-Squibb (HK) - General Award
Start Date:10/2003


Project Title:A randomized, double-blind trial of Telbivudine (LdT) versus Lamivudine in adults with decompensated chronic hepatitis B and evidence of cirrhosis
Investigator(s):Lai CL, Yuen RMF
Department:Medicine
Source(s) of Funding:Idenix Pharmaceuticals, Inc - General Award
Start Date:01/2004


List of Research Outputs

Chan V.N.Y., Lai C.L., Chan K. and Yuen R.M.F., Hepatitis B virus array for genotyping and mutation detection, Hong Kong Medical Journal. 2014, 20(6): Suppl 6: 25-7.
Fung J.Y.Y., Wong D.K.H., Seto W.K.W., Kopaniszen M., Lai C.L. and Yuen R.M.F., Hepatitis B Surface Antigen Seroclearance: Relationship to Hepatitis B e-Antigen Seroclearance and Hepatitis B e-Antigen-Negative Hepatitis, The American Journal of Gastroenterology. 2014, 109: 1764-1770.
Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Management of chronic hepatitis B in severe liver disease, World Journal of Gastroenterology. 2014, 20(43): 16053–61.
Fung J.Y.Y., Lam Y.F., Chok K.S.H., Seto W.K.W., Wong C.L.T., Chan A.C.Y., Chan S.C., Lai C.L., Lo C.M. and Yuen R.M.F., Modified model for end stage liver disease score accurately predicts death or liver transplantation in acute flares of chronic hepatitis B, Poster presentaion at the International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2015, 62(Suppl 2): S537.
Gish R.G., Given B.D., Lai C.L., Locarnini S.A., Lau J.Y.N., Lewis D.L. and Schluep T., Chronic hepatitis B: Virology, natural history, current management and a glimpse at future opportunities, Antiviral Research. 2015, 121: 47-58.
Gish R.G., Yuen R.M.F., Chan H.L.Y., Given B.D., Lai C.L., Locarnini S.A., Lau J.Y.N., Wooddell C.I., Schluep T. and Lewis D.L., Synthetic RNAi triggers and their use in chronic hepatitis B therapies with curative intent, Antiviral Research. 2015, 121: 97-108.
Huang F.Y., Wong D.K.H., Seto W.K.W., Lai C.L. and Yuen R.M.F., Estradiol activated microrna 23a directly or synergistically with p53 implicated in sex difference in hepatocellular carcinoma development, 24th Annual Conference of APASL, March 12–15, 2015, Istanbul, Turkey. Hepatology International. 2015, 9 (Suppl 1): S137-8.
Hung I.F.N., Wong D.K.H., Poon R.T.P., Fong D.Y.T., Seto W.K.W., Fung J.Y.Y., Yuen J.C.H., Tiu T.M.R.J., Lai C.L. and Yuen R.M.F., Risk Factors and Post-resection Independent Predictive Score for the Recurrence of Hepatitis B-related Hepatocellular Carcinoma, 20th Medical Research Conference 2015, 17 Jan 2015, The University of Hong Kong, Hong Kong.. 2015.
Lai C.L., Co-chairperson (Clinical Research Presentations I & II, Keynote Lecture II), SKLLR Symposium 2014, Hong Kong, September 27, 2014. 2014.
Lai C.L., Effect of Nucleoside Analogues on Fibrosis, Hepatocellular Carcinoma and cccDNA in Chronic Hepatitis B, Asian Oncology Summit, 11th Annual Conference of the Organisation for Oncology and Translational Research and Viral Hepatitis Summit 2015, Shanghai, China, Apr 10-12, 2015. 2015.
Lai C.L., Hepatitis & you, 728 HKHEPBFREE Dinner Seminar on the World Hepatitis Day, Hong Kong, July 28. 2014.
Lai C.L., Interferon vs Nucleos/tide Analogues for the Treatment of Chronic Hepatitis B (Oral presentation), The 3rd International Hepatology Conference, Hepatology Society, Dhaka, Bangladesh, November 20, 2014.
Lai C.L., Interferon vs Nucleos/tide Analogues in Chronic Hepatitis B, The 3rd international Hepatology Conference organized by the Hepatology Society, Dhaka, Bangladesh, November 20-21, 2014.. 2014.
Lai C.L., Key Considerations in Long-term Treatment Journey – Safety Surveillance and Management, The 4th HBV Single Topic Conference, Asian Pacific Association for the Study of the Liver (APASL), Guangzhou, China, December 12-14, 2014. 2014.
Lai C.L. and Yuen R.M.F., Management of Chronic Hepatitis B in Patients from Special Populations, Cold Spring Harbor Perspectives in Medicine. 2015, 5: a021527-a021527.
Lai C.L. and Yuen R.M.F., Management of patients from special populations, In: Seeger C and Locarnini S, Hepatitis B and Delta viruses. Cold Spring Laboratory Press, 2015, 274-288.
Lai C.L., Member of Judging Panel, Roche Young Scientist Award (RYSA) 2014/2015. 2014.
Lai C.L., Organizing Committee Member, Gastroenterology and Urology of the 4th International Conference on Gastroenterology and Urology, Baltimore, USA, May 4-6. 2015.
Lai C.L., Profound Reduction of HBV Covalently Closed Circular DNA with Long-term Nucleoside/tide Analogue Therapy (Poster presentation), Liver Meeting 2014, AASLD, in Boston, MA, USA, between November 7-11, 2014.
Lai C.L., Wong D.K.H., Ip P.C.P., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lee B.P., Cullaro G., Wu C.H., Cheng C.T.K., Yuen J.C.H., Ngai W.S. and Yuen R.M.F., Profound Reduction of HBV Covalently Closed Circular DNA with Long-term Nucleoside/tide Analogue Therapy, Hepatology. 2014, 60, No. 4 (Suppl): 183A.
Lai C.L., Real World Long-Term Experience of CHB Management, Baraclude Sponsored Scientific Symposium entitled ‘Chronic Hepatitis B Updates in Asia Pacific - From Clinical Evidence to Real Life Patient Setting: What's New & What to Expect’, Kuala Lumper, Malaysia, May 16, 2015. 2015.
Lai C.L., Yuen R.M.F., Yang J.C., Knox S.J., Mo H.M., Han L.L., Brainard D.M., Mchutchison J.G., Wong V.W.S. and Chan H.L.Y., Sofosbuvir plus ribavirin for 12 16 or 24 weeks results in sustained virologic response over 97 % in genotype 1 and 6 HCV infection in Hong Kong, 24th Annual Conference of APASL, March 12–15, 2015, Istanbul, Turkey. Hepatology International. 2015, 9 (Suppl 1): S58.
Lai C.L., Transforming Your Minds: M, J, MJ, M, Medical Humanities Guest Speaker Series “Conversations and Connections Year 2, Medical Ethics and Humanities Unit, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, February 10, 2015. 2015.
Lai C.L., Treating Chronic Hepatitis B in 2015, Seminar on Viral Hepatitis for Nurses and Allied Health Professionals 2015, Department of Health, Hong Kong, May 14, 2015. 2015.
Lai C.L., Treatment Endpoints for CHB, The 4th HBV Single Topic Conference, Asian Pacific Association for the Study of the Liver (APASL), Guangzhou, China, December 12-14, 2014. 2014.
Lai C.L., Treatment Endpoints for Chronic Hepatitis B: HBsAg seroclearance vs HBV DNA suppression vs cccDNA reduction (Oral presentation), The 4th HBV Single Topic Conference, Asian Pacific Association for the Study of the Liver (APASL), Guangzhou, China, December 14, 2014.
Lai C.L., Turning Point in Chronic Hepatitis C, Joint Scientific Meeting in Chronic Hepatitis C Management jointly organized by Macao Society of Gastroenterology and Hepatology & Infection Control Association of Macao, Macau, March 6, 2015. 2015.
Lai C.L., 乙型及其他肝炎, Public seminar jointly organized by the Hong Kong Hep B Free Foundation and Eastern District Council, Causeway Bay Community Centre, Hong Kong, June 27, 2015. 2015.
Lai C.L., 乙型及其他肝炎, Seminar organized by the Hong Kong Hep B Free Foundation for the employees of Shangri-La, Hong Kong, August 4. 2014.
Lam Y.F., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Continuous entecavir for treatment naı¨ve chinese chronic hepatitis B patients in the real world setting the seven year results, 24th Annual Conference of APASL, March 12–15, 2015, Istanbul, Turkey. Hepatology International. 2015, 9 (Suppl 1): S204-5.
Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Liu S.H.K., Singh G.H.H., Lam Y.F., Fung J.Y.Y., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., A prospective study of hepatitis B reactivation in patients with prior HBV exposure undergoing hematopoietic stem cell transplantation: Reactivation association with graft-versus-host disease, Oral presentation at the International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2015, 62(Suppl 2): S194.
Seto W.K.W., Lau E.H.Y., Wu J.T.K., Hung I.F.N., Leung W.K., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., An epidemiological association between the trends of nucleoside analogue prescription and liver cancer incidence from 1999 to 2012 in Hong Kong, China, Poster presentation at the International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2015, 62(Suppl 2): S435.
Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Hepatitis B reactivation in patients with prior HBV exposure undergoing rituximab-containing chemotherapy for lymphoma: a prospective study, Journal of Clinical Oncology. 2014, 32(33): 3736-43.
Seto W.K.W., Tanaka Y., Wong D.K.H., Shinkai N., Cheung K.S., Liu S.H.K., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Longitudinal serologic profiles up to 5 years in hepatitis B surface antigen-negative chronic hepatitis B, Hepatology. 2014, 60, No. 4 (Suppl): 57A.
Wong D.K.H., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Zhang J., Hung I.F.N., Lai C.L. and Yuen R.M.F., Identification of Hepatitis B Virus DNA Polymerase Sequences to Predict Virological Response to Entecavir Therapy, Health Research Symposium 2014, Hong Kong, 15 Nov 2014. (Poster presentation). 2014.
Wong D.K.H., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Identification of hepatitis B virus DNA reverse transcriptase variants associated with partial response to entecavir, Hong Kong Medical Journal. 2015, 21(Suppl 4): 35-8.
Wong D.K.H., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Hung I.F.N., Young J.L.P., Yuen J.C.H., Ngai W.S., Yuen R.M.F. and Lai C.L., Reduction of hepatitis B core related antigen by long term nucleoside nucleotide analogue therapy and its correlation with intrahepatic HBV DNA reduction, 24th Annual Conference of APASL, March 12–15, 2015, Istanbul, Turkey. Hepatology International. 2015, 9 (Suppl 1): S202.
Yuen R.M.F. and Lai C.L., Hepatitis B in 2014: HBV research moves forward—receptors and reactivation, Nature Reviews Gastroenterology & Hepatology. 2014, 12: 70-72.
ZHANG A., Wong D.K.H., Huang F.Y., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Evolutionary changes of hepatitis B virus pre-S mutations prior to development of hepatocellular carcinoma, Poster presentation at the International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2015, 62(Suppl 2): S543.


Researcher : Lai KN
Project Title:The role of the renin-angiotensin system in the tubulointerstitial injury of IgA nephropathy (IgAN)
Investigator(s):Lai KN, Leung JCK
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2004


List of Research Outputs

LI R., Yiu W.H., Wu H., LIN M., WONG W.L.D., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., BMP7 Reduces Tubular Inflammation and Oxidative Stress in Diabetic Nephropathy, J Am Soc Nephrol. 2014, 25: 216A.
LI R., Yiu W.H., Wu H., WONG W.L.D., Chan Y.Y., LIN M., Leung J.C.K., Lai K.N. and Tang S.C.W., BMP7 reduces inflammation and oxidative stress in diabetic tubulopathy, Clinical Science [IF 5.629]. 2015, 128(4): 269-280.
Lai K.N., Leung J.C.K. and Tang S.C.W., The treatment of IgA nephropathy, Kidney Dis . 2015.
Lim A.I., Chan Y.Y., Tang S.C.W., Lai K.N. and Leung J.C.K., Albumin and glycated albumin activate KIM-1 release in tubular epithelial cells through distinct kinetics and mechanisms, Inflammation Research [Epub ahead of print]. 2014.
Tang S.C.W., Yiu W.H., LIN M. and Lai K.N., Diabetic Nephropathy and Proximal Damage, Journal of Renal Nutrition [IF 2.548]. 2015, 25(2): 230-233.
Yap Y.H.D. and Lai K.N., Pathogenesis of Renal Disease in Systemic Lupus Erythematosus—The Role of Autoantibodies and Lymphocytes Subset Abnormalities, International Journal of Molecular Sciences. 2015, 16: 7917-7931.
Yiu W.H., WONG W.L.D., Leung J.C.K., Chan Y.Y., Lai K.N. and Tang S.C.W., Thrombin Induces Epithelial-Mesenchymal Transition Through the Activation of PAR-1 in Tubular Epithelial Cells, J Am Soc Nephrol. 2014, 25: 730A.


Researcher : Lai KWH
List of Research Outputs

Bao X., Wu H., Zhu X., Guo X., Hutchins A.P., Luo Z., Song H., CHEN Y., Lai K.W.H., Yin M., Xu L., Zhou L., Chen J., Wang D., Qin B., Frampton J., Tse H.F., Pei D., Wang H. and Zhang B., The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters., Cell Res. 2015. 2015, 25(1): 80-92.
Lee Y.K., Ran X., Lai K.W.H., Lau V.Y.M., Siu D.C.W. and Tse H.F., Generation and Characterization of Patient-SpecificInduced Pluripotent Stem Cell Model for Cardiovascular Disease, Springer Protocols. 2015.
Liao S., Liu Y., Zhang Y., Au K.W., Lai K.W.H., Siu D.C.W. and Tse H.F., Remodelling of cardiac sympathetic re-innervation with thoracic spinal cord stimulation improves left ventricular function in a porcine model of heart failure., Europace. 2015, 2105 MAR 12: 409.
NG A.K.Y., Ng K.M., Tse H.F., Lai K.W.H., CHAN W.S., Siu D.C.W. and Fan K., Pseudo-Pre-Excitation Unraveled Down to Its Core, Circulation. 2014, 130: e56-e58.


Researcher : Lai TST
List of Research Outputs

Hung I.F.N., Chan K.H., Liang R.H.S., Lai T.S.T. and Yuen K.Y., Harvesting Convalescent Plasma for Hyperimmune Intravenous Globulin Production: A Multicentre Randomized Double-Blind Controlled Trial for Treatment of Patients with Serious S-OIV H1N1 Infection, Health Research Symposium 2014, Hong Kong, 15 Nov 2014. (Poster presentation). 2014.


Researcher : Lai YKA
List of Research Outputs

Lai Y.K.A., Fong D.Y.T., Lam C.M.J., Weaver T.E. and Ip M.S.M., The efficacy of a brief motivational enhancement education program on continuous positive airway pressure adherence in obsrtuctive sleep apnea: a randomized controlled trial, Chest. 2014, 146(3): 600-610.


Researcher : Lam B
List of Research Outputs

Hui Y.L.E., Lee A.C., Lang H.H.B., Chan A.O. and Lam B., Congenital adrenal hyperplasia presenting as a large adrenal incidentaloma in an elderly man, ANZ Journal of Surgery. 2014, Epub ahead of print.


Researcher : Lam CL
Project Title:The role of nicotinic acetylcholine receptor (nAChR) in bronchial epithelium in relation to lung carcinogenesis
Investigator(s):Lam CLD, Ip MSM, Tsao GSW, Lam WK
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2010


Project Title:Establishment of molecular tests for personalized therapy regime for lung cancer
Investigator(s):Lam CLD, Chan VNY, Ip MSM, Lee VHF
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:09/2010


Project Title:Therapeutic target gene mutation analysis for newly established lung cancer cell lines from local Chinese patients
Investigator(s):Lam CLD
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2011


Project Title:Clinical applications of different driver mutations and biomarkers in lung cancer
Investigator(s):Lam CLD, Wan TSK
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:09/2012


Project Title:Application of an EGFR array for the detection of Epidermal Growth Factor Receptor (EGFR) gene mutation in patients with Non-Small Cell Lung Cancer (NSCLC)
Investigator(s):Lam CLD
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2014


List of Research Outputs



Researcher : Lam CLD
Project Title:The role of nicotinic acetylcholine receptor (nAChR) in bronchial epithelium in relation to lung carcinogenesis
Investigator(s):Lam CLD, Ip MSM, Tsao GSW, Lam WK
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2010


Project Title:Establishment of molecular tests for personalized therapy regime for lung cancer
Investigator(s):Lam CLD, Chan VNY, Ip MSM, Lee VHF
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:09/2010


Project Title:Therapeutic target gene mutation analysis for newly established lung cancer cell lines from local Chinese patients
Investigator(s):Lam CLD
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2011


Project Title:Clinical applications of different driver mutations and biomarkers in lung cancer
Investigator(s):Lam CLD, Wan TSK
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:09/2012


Project Title:Application of an EGFR array for the detection of Epidermal Growth Factor Receptor (EGFR) gene mutation in patients with Non-Small Cell Lung Cancer (NSCLC)
Investigator(s):Lam CLD
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2014


List of Research Outputs

Fysh E.T., Thomas R., Read C.A., Kwan B.C., Yao E., Horwood F.C., Lee P., Piccolo F., Shrestha R., Garske L.A., Lam C.L.D., Rosenstengel A., Bint M., Murray K., Smith N.A. and Lee Y.C., Protocol of the Australasian Malignant Pleural Effusion (AMPLE) trial: a multicentre randomised study comparing indwelling pleural catheter versus talc pleurodesis, BMJ Open. 2014, 4 (11): e006757.
LUO Y., Sit A.K., Sihoe D.L.A., Suen W.S., Au T.W.K., Tang X., Ma E.S.K., Chan W.K., Wistuba I.I., Minna J.D., Tsao G.S.W. and Lam C.L.D., Aberrant large tumor suppressor 2 (LATS2) gene expression correlates with EGFR mutation and survival in lung adenocarcinomas, Lung Cancer. Elsevier, 2014, 85 (2): 282 - 292.
Lam C.L.D., Associate Editor, Respirology. 2015.
Lam C.L.D., Associate Editor, Respirology Case Reports. 2014.
Lam C.L.D., Nana A. and Eastwood P.R., Electronic cigarettes – “vaping” has unproven benefits and potential harm, Respirology. Blackwell, 2014.
Lam C.L.D., How to prevent COPD by early action? , 2015.
Lam C.L.D., How to prevent exacerbations of COPD?, Tenth Symposium on Healthy Aging. 2015.
Lam C.L.D., Lam K.S.L. and Ip M.S.M., Obstructive sleep apnoea, insulin resistance and adipocytokines, Clinical Endocrinology. Wiley, 2014.
Lam C.L.D., Luo S.Y., Deng W., Kwan S.H., Rodriguez-Canales J., Cheung A., Cheng G.H.W., Lin C.H., Wistuba I.I., Sham P.C., Wan T.S.K. and Tsao G.S.W., Oncogenic mutation profiling in new lung cancer and mesothelioma cell lines, OncoTargets and Therapy. 2015, 8: 195-209.
Lam C.L.D., Tam C.C.T., Lau K.M., Wong W.M., Hui K.M.C., Lam J.C., Wang J.K., Lui M.S.M., Ho J.C.M. and Ip M.S.M., Plasma EGFR Mutation Detection Associated With Survival Outcomes in Advanced-Stage Lung Cancer, Clinical Lung Cancer [Epub ahead of print]. 2015.
Lam C.L.D., Sir Patrick Manson Gold Medal, University of Hong Kong. 2014.
Lam C.L.D., Targeted therapy for Lung Cancer, ESAP: APSR Congress 2014. 2014.
Lee J.C., Pang S.Y., Lam C.L.D., Tse A.C., Lau G.K.K., Chang S.K.R., Ho S.L., Cheung R.T.F., Mak W., Hon F.K.S., Chang C.K., Teo K.L. and Chan K.H., Myasthenic crisis in patients with generalised myasthenia gravis. Hong Kong Academy of Medicine, 2014., 2015.
Lim S., Lam C.L.D., Muttalif A.R., Yunus F., Wongtim S., Le Thi Tuyet L., Shetty V., Chu R., Zheng J., Perng D.W. and de Guia T., Impact of chronic obstructive pulmonary disease (COPD) in the Asia-Pacific region: the EPIC Asia population-based survey., Asia Pacific Family Medicine. 2014, 14 (1): 4.


Researcher : Lam CLK
Project Title:Evaluation Study on Quality of Care of Healthcare Programmes
Investigator(s):Lam CLK, Lam TP, Chin WY, Chen JY, Lam TP
Department:Med - Family Medicine Unit
Source(s) of Funding:Hospital Authority - General Award
Start Date:04/2010


Project Title:Epidemiological Study on Different Body Constitution for the "Treatment of Not Yet ill " Programme.
Investigator(s):Lam CLK, Wong W
Department:Med - Family Medicine Unit
Source(s) of Funding:Hospital Authority - General Award
Start Date:04/2010


Project Title:Extended evaluation of quality of care of chronic disease management programmes and public-private partnership programmes of the Hospital Authority
Investigator(s):Lam CLK, Wong WCW, Chin WY, Chen JY, Fung SCC, Fong DYT, Yu YTE
Department:Family Med & Primary Care
Source(s) of Funding:Commissioned Study on Enhanced Primary Care
Start Date:07/2011


Project Title:The 42nd North American Primary Care Research Group (NAPCRG) Annual Meeting; Paper presentation at pre-conference workshop " International Collaboration in Innovating Health Systems"/Poster presentation on " A RCT to assess the effect of timing of incentive payments on rates of cohort study telephone interviews'
Investigator(s):Lam CLK
Department:Family Med & Primary Care
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:11/2014
Completion Date:11/2014




Researcher : Lam CMJ
List of Research Outputs

Lai Y.K.A., Fong D.Y.T., Lam C.M.J., Weaver T.E. and Ip M.S.M., The efficacy of a brief motivational enhancement education program on continuous positive airway pressure adherence in obsrtuctive sleep apnea: a randomized controlled trial, Chest. 2014, 146(3): 600-610.


Researcher : Lam KSL
Project Title:The Endocrine Society's 88th Annual Meeting Adipocyte Fatty Acid Binding Protein as a Potential Circulating Metabolic Hormone: Clinical and Functional Studies
Investigator(s):Lam KSL
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2006


Project Title:Obesity, adipose tissue inflammation and atherosclerosis: role of JNK activation
Investigator(s):Lam KSL, Xu A
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2011


Project Title:To Establish a Metabolic Study Centre in Hong Kong: Focusing on the Emerging Metabolic Hormones
Investigator(s):Lam KSL, Xu A, Wang Y, Cheung BMY, Wong CM
Department:Medicine
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2013


Project Title:Ageing
Investigator(s):Lam KSL, Xu A, Lum TYS
Department:Medicine
Source(s) of Funding:Seed Funding for Strategic Research Theme
Start Date:09/2013


Project Title:Establishing a Phase 1 Clinical Trials Centre in Queen Mary Hospital: Extending Hong Kong's Competitive Edges in Healthcare, Education and Life Sciences Research and Development
Investigator(s):Lam KSL, Lau YL, Cheung BMY, Lam CW, Yau HKC
Department:Medicine
Source(s) of Funding:Commissioned Programme on Phase 1 Clinical Trials Centre
Start Date:02/2014


List of Research Outputs

Cheung C.L., Lam K.S.L., Wong I.C.K. and Cheung B.M.Y., Non-invasive score identifies ultrasonography-diagnosed non-alcoholic fatty liver disease and predicts mortality in the USA, BMC Medicine. 2014, 12: 154.
Cheung Y.Y., Hui Y.L.E., Cheung B.M.Y., Woo Y.C., Xu A., Fong H.Y., Ong K.L., Yeung C.Y., Janus E.D., Tse H.F., Sham P.C. and Lam K.S.L., Adiponectin gene variants and the risk of coronary heart disease: a 16-year longitudinal study., Eur J Endocrinol. 2014, 171: 107-115.
Gu P., Hui X., Vanhoutte P.M.G.R., Lam K.S.L. and Xu A., Deletion of SIRT1 in perivascular adipose tissue accelerates obesity-induced endothelial dysfunction , ASCEPT-BPS2015.
Hui Y.L.E., Yeung C.Y., Lee P.C.H., Woo Y.C., Fong H.Y., Chow W.S., Xu A. and Lam K.S.L., Elevated Circulating Pigment Epithelium-Derived Factor Predicts the Progression of Diabetic Nephropathy in Patients With Type 2 Diabetes, The Journal of Clinical Endocrinology & Metabolism. 2014, 99: E2169-E2177.
Hui Y.L.E., Xu A., Chow W.S., Lee P.C.H., Fong H.Y., Cheung C.W.S., Tse H.F., Chau M.T., Cheung B.M.Y. and Lam K.S.L., Hypoadiponectinemia As an Independent Predictor for the Progression of Carotid Atherosclerosis: A 5-Year Prospective Study, Metabolic Syndrome and Related Disorders. 2014, 12: 517-522.
KWOK H.M., Cheng K.Y., Li F.Y.L., Chan Y.C.C., Hoo R.L.C., Ye D., Xu A. and Lam K.S.L., Inactivation of c-Jun N-terminal Kinase in Adipose Tissue Alleviates Atherosclerosis in Diet-induced Obese ApoE-deficient Mice, 83rd European Atherosclerosis Society Congress. 2015.
Lam C.L.D., Lam K.S.L. and Ip M.S.M., Obstructive sleep apnoea, insulin resistance and adipocytokines, Clinical Endocrinology. Wiley, 2014.
Lam K.S.L., Adiponectin, Diabetes and Diabetic Complications. (Plenary lecture), 13th Continuing Professional Development Series: “Diabetes Asia 2014” Conference, 16-19 Oct 2014, Kuala Lumpur. 2014.
Lam K.S.L., Chan Y.C.C., Stillitano A., Wong C.M., Pang Y. and Xu A., Adipose tissue FGF21 resistance contributes to hypoadiponectinemia and insulin resistance in obesity: Role of miR-34a, The 75th Scientific Sessions of the American Diabetes Association, 5-9 Jun 2015, Boston, USA. 2015.
Lam K.S.L., Endocrinology & diabetes training in UK and Hong Kong, The Annual Congress of the Chinese Endocrinologist Association of Chinese Medical Doctor Association, 10-12 July, Xiamen, China. 2014.
Lam K.S.L., Honorary President, Diabetes Hongkong. 2014.
Lam K.S.L., Support Program for People with Diabetes in the Community: Experience from Hong Kong, 13th Continuing Professional Development Series: “Diabetes Asia 2014” Conference, 16-19 Oct 2014, Kuala Lumpur. 2014.
Lam K.Y.J., Lam K.S.L., Chow W.S. and Tan K.C.B., A middle-aged man with increasing body fat, Clinical Obesity. 2014, n/a-n/a.
Lee C.H.P. and Lam K.S.L., Biomarkers of progression in diabetic nephropathy: The past, present and future, Journal of Diabetes Investigation. 2015, 6: 247-249.
Lee C.H.P., Hui Y.L.E., Woo Y.C., Yeung C.Y., Chow W.S., Yuen M.A.M., Fong H.Y., Xu A. and Lam K.S.L., Circulating Fibroblast Growth Factor 21 Levels Predict Progressive Kidney Disease in Subjects With Type 2 Diabetes and Normoalbuminuria, The Journal of Clinical Endocrinology & Metabolism. 2015, 100: 1368-1375.
Lee C.H.P., Woo Y.C., Wang Y., Yeung C.Y., Xu A. and Lam K.S.L., Obesity, adipokines and cancer: an update, Clinical Endocrinology. 2014, 83(2): 147-156.
Lee C.H.P., Woo Y.C., Fong C., Pau H.Y.N., Lam K.S.L. and Tan K.C.B., Validation of the Pooled Cohort Equations in a Hong Kong Chinese Cohort., 17th International Symposium on Atherosclerosis, Amsterdam, May 2015.
Leung A.Y.M., Cheung M.K.T., Yu Y.T.E., Lam C.L.K. and Lam K.S.L., Building Diabetes Literacy through Smartphone Application: Feasibility and Challenges, The 10th International Symposium on Healthy Aging. 2015.
Li R.H.W., Lam K.S.L., Tam S., Lee V.C.Y., Yeung T.W.Y., Cheung P.T., Yeung W.S.B., Ho P.C. and Ng E.H.Y., Screening for dysglycaemia by oral glucose tolerance test should be recommended in all women with polycystic ovary syndrome., Human Reproduction. 2015, 30(9): 2178-2183.
Ng C.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Lam K.S.L., Xu A. and Chan K.H., Adiponectin deficiency induced cognitive dysfunction and Alzheimer’s disease pathogenesis in mice through the disruption of insulin sensitivity and inactivated AMPK signaling , 67th American Academy of Neurology Annual Meeting. 2015.
Ng C.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Lam K.S.L., Xu A. and Chan K.H., Research Travel Scholarship 2015, American Academy of Neruology. 2015.
SHU L., WU X., CHEONG L.Y., Zhou M., Lam K.S.L., Xu A. and Hoo R.L.C., Adipocyte fatty acid binding protein (A-FABP) is a potential regulator of adaptive thermogenesis, Tenth international symposium on healthy aging"A decade of positive aging ". 2015.
SING C.W., Cheung C.L., Lam K.S.L. and Cheung B.M.Y., Low lean mass and gait speed in people with both diabetes and peripheral arterial disease, Tenth International Symposium on Healthy Aging, " A Decade of Positive Aging" March 7-8, 2015, Hong Kong. 2015.
So W.Y., Cheng Q., Xu A., Lam K.S.L. and Leung P.S., Loss of fibroblast growth factor 21 action induces insulin resistance, pancreatic islet hyperplasia and dysfunction in mice, Cell Death and Disease. 2015, 6: e1707.
WANG B., Cheng K.Y., Li X., Lam K.S.L. and Xu A., Hypothalamic APPL2 combats against obesity by promoting adaptive thermogenesis in white adipose tissues, EMBL Symposium: Translating Diabetes.. 2015.
WANG B., Cheng K.Y., Li X., Li A., Lam K.S.L. and Xu A., The Role of Hypothalamic APPL2 in Regulation of Energy Expenditure in Adipose Tissues, 2015 Asia Pacific obesity and diabetes symposium.. 2015.
WANG B., Cheng K.Y., Li X., Li A., Lam K.S.L. and Xu A., The hypothalamic APPL2 as a novel regulator of energy homeostasis in adipose tissues, The 10th International Symposium on Healthy Aging 2015. A Decade of Positive Aging. 2015.. 2015.
WANG Y., Xiao Y., ZHONG L., Ye D., Zhang J., Tu Y., Bornstein S.R., Zhou Z., Lam K.S.L. and Xu A., Increased Neutrophil Elastase and Proteinase 3 and Augmented NETosis Are Closely Associated With  -Cell Autoimmunity in Patients With Type 1 Diabetes, Diabetes. 2014, 63: 4239-4248.
Wong C.M., WANG Y., LEE T.H.J., HUANG Z., Wu D., Xu A. and Lam K.S.L., Adropin is a brain membrane-bound protein regulating physical activity via NB-3/Notch signaling pathway in mice, The Journal of Biological Chemistry. 2014.
Woo Y.C., Cheung B.M.Y., Yeung C.Y., Lee C.H.P., Hui Y.L.E., Fong H.Y., Tso A.W.K., Tam S. and Lam K.S.L., Cardiometabolic risk profile of participants with prediabetes diagnosed by HbA1c criteria in an urban Hong Kong Chinese population over 40 years of age , Diabetic Medicine. 2015, n/a-n/a.
Ye D., Wang Y., Li H., Jia W., Man K., Lo C.M., Wang Y., Lam K.S.L. and Xu A., Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1α-mediated antioxidant capacity in mice, Hepatology. 2014, 60: 977-989.
Zhou M., PAN Y., SHU L., Lam K.S.L., Xu A. and Hoo R.L.C., A-FABP is a potential mediator of diabetic cardiomyopathy and ischemic reperfusion induced cardiac injury , 17th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM) . 2014.


Researcher : Lam KYJ
List of Research Outputs

Lam K.Y.J., Lam K.S.L., Chow W.S. and Tan K.C.B., A middle-aged man with increasing body fat, Clinical Obesity. 2014, n/a-n/a.


Researcher : Lam MF
List of Research Outputs

Shea Y.F., Lam M.F., Lee M.S., Mok T.M.Y., Lui S.L., Yip T.P.S., Lo W.K., Chu L.W. and Chan D.T.M., Prevalence of CMMSE defined cognitive impairment among peritoneal dialysis patients and its impact on peritonitis, Clinical And Experimental Nephrology. 2015, 21 May 2015: Epub ahead of print.
Yung S.S.Y., Lui S.L., Ng K.F., Yim A.S.Y., Ma K.M.M., Lo W.K., Chow C.C., Chu K.H., Chak W.L., Lam M.F., Yung C.Y., Yip T.P.S., Wong S., Tang S.O.C., Ng F.S.K. and Chan D.T.M., Impact of a Low-Glucose Peritoneal Dialysis Regimen on Fibrosis and Inflammation Biomarkers, Peritoneal Dialysis International. 2015, 35: 147-158.


Researcher : Lam SK
Project Title:Biotech Company in the Faculty of Medicine, The University of Hong Kong
Investigator(s):Lam SK
Department:Medicine
Source(s) of Funding:The University of Hong Kong Foundation Seed Grant
Start Date:07/2003


Project Title:Treatment of gastrointestinal cancer by targeting survivin using adeno-associated virus gene delivery system
Investigator(s):Lam SK, Wong BCY, Lin MC
Department:LKS Medical Faculty
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2004




Researcher : Lam SK
Project Title:Investigation of apoptotic and E2F1 pathways induced by arsenic trioxide in non-small cell lung carcinoma
Investigator(s):Lam SK, Ho JCM
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:01/2014


List of Research Outputs

LEUNG L.L., Lam S.K. and Ho J.C.M., Arsenic trioxide Suppresses Tumour Growth in Squamous Cell Lung Carcinoma , 20th Medical Research Conference. Hong Kong Medical Journal, 2015, 21: 53.
LI Y., Lam S.K., ZHENG C., LEUNG L.L. and Ho J.C.M., The effect of tumor microenvironment on autophagy and sensitivity to targeted therapy in EGFR-mutated lung adenocarcinoma , 21st Hong Kong International Cancer Congress. 2014.
Lam S.K., LI Y., ZHENG C., LEUNG L.L. and Ho J.C.M., Combination Effect of Arsenic Trioxide and FGFR Inhibitor through Downregulation of FGFR, Akt and Erk in Squamous Cell Lung Carcinoma, 21st Hong Kong International Cancer Congress. 2014.
Lam S.K., LI Y., ZHENG C. and Ho J.C.M., Downregulation of Thymidylate Synthase and E2F1 by Arsenic Trioxide in Mesothelioma , Work Injury Prevention and Rehabilitation 2014.
Lam S.K., LI Y., ZHENG C. and Ho J.C.M., Downregulation of thymidylate synthase and E2F1 by arsenic trioxide in mesothelioma., International journal of oncology. 2014, 46: 113-22.
Lam S.K., LI Y., ZHENG C., LEUNG L.L. and Ho J.C.M., E2F1 Downregulation by Arsenic Trioxide in Lung Adenocarcinoma, International Journal of Oncology. 2014, 45: 2033-43.
Lam S.K., LEUNG L.L. and Ho J.C.M., Massive degradation in FGFR/Akt/Erk signaling by arsenic trioxide and FGFR inhibitor PD173074 in squamous cell lung carcinoma SK-MES-1, 20th Medical Research Conference. Hong Kong Medical Journal, 2015, 21: 30.
Li Y.V., Lam S.K., Zheng C. and Ho J.C.M., The Effect of Tumor Microenvironment on Autophagy and Sensitivity to Targeted Therapy in EGFR-Mutated Lung Adenocarcinoma, Journal of Cancer. 2015, 6: 382-386.
ZHENG C., Lam S.K., LI Y., LEUNG L.L. and Ho J.C.M., Arsenic trioxide-induced cytotoxicity in small cell lung cancer via altered redox homeostasis and mitochondrial integrity , 21st Hong Kong International Cancer Congress. 2014.
ZHENG C., Lam S.K., LI Y. and Ho J.C.M., Arsenic trioxide-induced cytotoxicity in small cell lung cancer via altered redox homeostasis and mitochondrial integrity., International journal of oncology. 2014, 46: 1067-1078.


Researcher : Lam TP
Project Title:What are the enablers and barriers of help-seeking among the psychologically distressed in primary care setting? - Promoting mental well-being in Hong Kong
Investigator(s):Lam TP, Lam KF, Lam WW
Department:Family Med & Primary Care
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2013


Project Title:Early detection of dementia: the knowledge, attitudes and practice of primary care physicians.
Investigator(s):Lam TP, Leung CW, Lam KF, Wong KW, Chao DVK
Department:Family Med & Primary Care
Source(s) of Funding:Small Project Funding
Start Date:06/2013
Completion Date:11/2014


Project Title:The barriers and facilitators to undertaking continuing professional education among the private non-specialist primary care physicians in Hong Kong
Investigator(s):Lam TP, Lam KF
Department:Family Med & Primary Care
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2014


Project Title:Depression and Anxiety in Global Primary Care Settings - A Field Study for the ICD-11-PHC
Investigator(s):Lam TP, Lo TL, Lam KF, Lam WW
Department:Family Med & Primary Care
Source(s) of Funding:Small Project Funding
Start Date:06/2014
Completion Date:05/2015


Project Title:How to promote primary care in Zhejiang province, China? – A combined qualitative and quantitative study
Investigator(s):Lam TP, Lam KF
Department:Family Med & Primary Care
Source(s) of Funding:Small Project Funding
Start Date:03/2015


List of Research Outputs

Chin W.Y., Chan T.Y., Lam C.L.K., Lam T.P. and Wan Y.F., Help-seeking intentions and subsequent 12-month mental health service use in Chinese primary care patients with depressive symptoms, BMJ Open. 2015, 5: e006730-e006730.


Researcher : Lam YF
List of Research Outputs

Fung J.Y.Y., Lam Y.F., Chok K.S.H., Seto W.K.W., Wong C.L.T., Chan A.C.Y., Chan S.C., Lai C.L., Lo C.M. and Yuen R.M.F., Modified model for end stage liver disease score accurately predicts death or liver transplantation in acute flares of chronic hepatitis B, Poster presentaion at the International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2015, 62(Suppl 2): S537.
Lam Y.F., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Continuous entecavir for treatment naı¨ve chinese chronic hepatitis B patients in the real world setting the seven year results, 24th Annual Conference of APASL, March 12–15, 2015, Istanbul, Turkey. Hepatology International. 2015, 9 (Suppl 1): S204-5.
Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Liu S.H.K., Singh G.H.H., Lam Y.F., Fung J.Y.Y., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., A prospective study of hepatitis B reactivation in patients with prior HBV exposure undergoing hematopoietic stem cell transplantation: Reactivation association with graft-versus-host disease, Oral presentation at the International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2015, 62(Suppl 2): S194.
Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Hepatitis B reactivation in patients with prior HBV exposure undergoing rituximab-containing chemotherapy for lymphoma: a prospective study, Journal of Clinical Oncology. 2014, 32(33): 3736-43.
Tan V.P.Y., Liu S.H.K., Lam Y.F., Hung I.F.N., Yuen R.M.F. and Leung W.K., Rifaximin for the Treatment of Functional Dyspepsia: A Double-Blind Randomized Placebo-Controlled Trial., Digestive Diseases Week 2015.


Researcher : Lan HY
Project Title:Essential role of SMAD3 in cardiac repair and fibrosis
Investigator(s):Lan HY
Department:Medicine
Source(s) of Funding:Sun Chieh Yeh Heart Foundation - General Award
Start Date:08/2006


Project Title:Role of Smad signalling in the pathogenesis of hypertensive nephropathy and a novel therapeutic potential using ultrasound-microbubble-mediated transfer of inducible Smad7
Investigator(s):Lan HY
Department:Medicine
Source(s) of Funding:Baxter Health Care Ltd. - General Award
Start Date:05/2008


Project Title:Gene therapy for diabetic nephropathy using ultrasound-microbubble-mediated transfer of inducible smad7
Investigator(s):Lan HY
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:05/2008




Researcher : Lan XR
Project Title:Mechanisms of Peritoneal Fibrosis: Role of TGF-beta Signaling
Investigator(s):Lan XR, Lan HY, Leung JCK
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2008




Researcher : Lau CP
Project Title:Evaluation of the antianginal efficacy and safety of oral chronic administration of ivabradine (5mg b.i.d. then 7.5mg b.i.d or 10mg b.i.d) compared to atenolol (50mg o.d then 100mg o.d), in patients with stable effort angina pectorals
Investigator(s):Lau CP, Lee KLF
Department:Medicine
Source(s) of Funding:Other Funding Scheme
Start Date:05/2000


Project Title:Roles of macrophage migration inhibitory factor (MIF) in acute myocardial infarction
Investigator(s):Lau CP, Yu CM, Lan HY
Department:Medicine
Source(s) of Funding:Low Budget High Impact Programme
Start Date:11/2000


List of Research Outputs

Chan Y.H., Yiu K.H., Lau G.K.K., Yiu Y.F., Li S.W., Lam T.H., Lau C.P., Siu C.W. and Tse H.F., The CHADS2 and CHA2DS2-VASc scores predict adverse vascular function, ischemic stroke and cardiovascular death in high-risk patients without atrial fibrillation: Role of incorporating PR prolongation, Atherosclerosis. 2014, 237(2): 504-13.
Chan Y.H., Lau K.K., Yiu K.H., Li L.S.W., Tam S., Lam T.H., Lau C.P., Siu D.C.W., Cheung B.M.Y. and Tse H.F., Vascular protective effects of statin-related increase in serum 25-hydroxyvitamin D among high-risk cardiac patients, Journal of Cardiovascular Medicine. 2015, 16: 51-58.
Chan Y.H., Lau G.K.K., Yiu K.H., Li L.S.W., Tam S., Lam T.H., Lau C.P., Siu D.C.W., Cheung B.M.Y. and Tse H.F., Vascular protective effects of statin-related increase in serum 25-hydroxyvitamin D among high-risk cardiac patients, Journal of Cardiovascular Medicine (Hagerstown). 2015.
Healey J.S., Brambatti M., Gold M.R., Morillo C.A., Capucci A., Muto C., Lau C.P., Van Gelder I.C., Hohnloser S.H., Carlson M., Fain E., Nakamya J., Mairesse G.H., Halytska M., Deng W.Q., Israel C.W. and Connolly S.J., Response to Letter Regarding Article "Temporal Relationship Between Subclinical Atrial Fibrillation and Embolic Events", Circulation. 2015, 131: e337-e338.
Ho C.W., Ho M.H., Chan P.H.M., Hai S.H.J.J., Cheung E., Yeung C.Y., Lau G.K.K., Chan K.H., Lau C.P., Lip G.Y., Leung G.K.K., Tse H.F. and Siu D.C.W., Ischemic stroke and intracranial hemorrhage with aspirin, dabigatran, and warfarin: impact of quality of anticoagulation control, Stroke. 2015.
Lau Y.M., Hui W.M. and Lau C.P., Asystole complicating acalculous cholecystitis, the “Cope's sign” revisited, International Journal of Cardiology. 2015, 182: 447-448.
Yiu K.H., Ng W.S., Chan D., Sit K.Y., Wong A., Lee C.W., Chum H.L., Cheung W.Y., Pun C.T., Ho K.L., CHEN Y., Ho K.M., Kumana C.R., Cheung H.L., Chung M.C., Lau C.P., Au K.W. and Tse H.F., Improved prognosis following renin-angiotensin-aldosterone system blockade in patients undergoing concomitant aortic and mitral valve replacement., Int J Cardiol. 2014. 2014, 177(2): 680-682.


Researcher : Lau G
Project Title:Prevalence and Natural History of Non-Alcoholic Fatty Liver Diseases in Hong Kong Chinese
Investigator(s):Lau G
Department:Medicine
Source(s) of Funding:Hong Kong Liver Foundation - General Award
Start Date:02/2005


Project Title:Basic science study on the disease mechanism, clinical surveillance and outcomes of severe hepatitis B infection
Investigator(s):Lau G
Department:Medicine
Source(s) of Funding:Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:12/2007




Researcher : Lau GKK
Project Title:Prevalence and Natural History of Non-Alcoholic Fatty Liver Diseases in Hong Kong Chinese
Investigator(s):Lau G
Department:Medicine
Source(s) of Funding:Hong Kong Liver Foundation - General Award
Start Date:02/2005


Project Title:Basic science study on the disease mechanism, clinical surveillance and outcomes of severe hepatitis B infection
Investigator(s):Lau G
Department:Medicine
Source(s) of Funding:Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:12/2007




Researcher : Lau GKK
List of Research Outputs

Chan Y.H., Yiu K.H., Lau G.K.K., Yiu Y.F., Li S.W., Lam T.H., Lau C.P., Siu C.W. and Tse H.F., The CHADS2 and CHA2DS2-VASc scores predict adverse vascular function, ischemic stroke and cardiovascular death in high-risk patients without atrial fibrillation: Role of incorporating PR prolongation, Atherosclerosis. 2014, 237(2): 504-13.
Chan Y.H., Lau G.K.K., Yiu K.H., Li L.S.W., Tam S., Lam T.H., Lau C.P., Siu D.C.W., Cheung B.M.Y. and Tse H.F., Vascular protective effects of statin-related increase in serum 25-hydroxyvitamin D among high-risk cardiac patients, Journal of Cardiovascular Medicine (Hagerstown). 2015.
Ho C.W., Ho M.H., Chan P.H.M., Hai S.H.J.J., Cheung E., Yeung C.Y., Lau G.K.K., Chan K.H., Lau C.P., Lip G.Y., Leung G.K.K., Tse H.F. and Siu D.C.W., Ischemic stroke and intracranial hemorrhage with aspirin, dabigatran, and warfarin: impact of quality of anticoagulation control, Stroke. 2015.
Lau G.K.K., Wong Y.K., Teo K.C., Li O.Y., Chan J., Chan S., Cheung R., Wong E., Wong E., Ho S.L., Mak H.K.F. and Rothwell P.M., Clinical correlates and prognostic implications of cerebral microbleeds detected by susceptibility weighted imaging in Chinese with ischaemic stroke, 10th International Symposium of Healthy Aging. 2015.
Lau G.K.K., Wong Y.K., Teo K.C., Li O.Y., Chan J., Chan S., Cheung R., Wong E., Wong E., Ho S.L., Mak H.K.F. and Rothwell P.M., Clinical correlates and prognostic implications of cerebral microbleeds detected by susceptibility weighted imaging in Chinese with ischaemic stroke, European Stroke Organisation Conference. 2015.
Lau G.K.K., Chan L.K., Li O.Y., Yuen T.K., Wong Y.K., Chan K.H., Chan J.F.W., Chang S.K.R., Cheung R.T.F., Doherty I., Ho S.L., Hon F.K.S., Kwan S.K.J., Lee R., Leung G.K.K., Mak W., Mak H.K.F., Shih K.C. and Tsang C.O.A., Establishing an eLearning Platform in Clinical Neurosciences, East-West Alliance Global Symposia 2014.
Lau G.K.K., Faculty Teaching Medal, The University of Hong Kong. 2014.
Lau G.K.K., Wong Y.K., Chan Y.H., Li O.Y., Lee P.Y.S., Yuen G.G., Wong Y.K., Tong S., Wong D. and Chan K.H., Mediterranean-Style Diet Is Associated With Reduced Blood Pressure Variability and Subsequent Stroke Risk in Patients With Coronary Artery Disease, American Journal of Hypertension. 2015, 28: 501-507.
Lau G.K.K., Chiu K.C.P., Shih K.C., Chu L.W., Ho S.L. and Mak W., Miller Fisher syndrome in a Chinese octogenarian presenting with dizziness, Asian Journal of Gerontology & Geriatrics. Hong Kong Academy of Medicine Press, 2014, 9:2: 93–5.
Lau G.K.K., Chan L.K., Chan K.H., Chang S.K.R., Chang R.C.C., Cheung R.T.F., Doherty I., Ho S.L., Hon S.F.K., Kwan S.K.J., Lee R., Leung G.K.K., Mak W., Shih K.C. and Tsang C.O.A., ePoster Award (First Prize), Title: Establishing an eLearning Platform in Clinical Neurosciences at HKU, HKU Li Ka Shing Faculty of Medicine Frontiers Series – East-West Alliance Global Symposia. 2014.
Lee J.C., Pang S.Y., Lam C.L.D., Tse A.C., Lau G.K.K., Chang S.K.R., Ho S.L., Cheung R.T.F., Mak W., Hon F.K.S., Chang C.K., Teo K.L. and Chan K.H., Myasthenic crisis in patients with generalised myasthenia gravis. Hong Kong Academy of Medicine, 2014., 2015.
Lee J.C.Y., Pang S.Y.Y., Tse C.T.A., Lau G.K.K., Chang S.K.R., Teo K.C. and Chan K.H., Thymomatous myasthenia gravis in Hong Kong Chinese, 20th Medical Research Conference, Department of Medicine, HKU. 2015.
Wong C.F., Lau G.K.K. and Fung S.L., Endobronchial tuberculosis: Always a diagnostic challenge, QJM. 2015.
Yao N., Cheung C., Pang S.Y.Y., Chang S.K.R., Lau G.K.K., Suckling J., Yu K., Mak H.K.F., Chua S.E., Ho S.L. and McAlonan G.M., Multimodal MRI of the hippocampus in Parkinson's disease with visual hallucinations, Brain Structure and Function. 2014.
Yao N., Pang S., Cheung C., Chang S.K.R., Lau G.K.K., Suckling J., Yu K., Mak H.K.F., McAlonan G., Ho S.L. and Chua S.E., Resting activity in visual and corticostriatal pathways in Parkinson’s disease with hallucinations, Parkinsonism and Related Disorders. 2015.


Researcher : Lau KS
List of Research Outputs

Kwan S.H., Hsu Y.H., Cheung C.L., Dupuis J., Saint-Pierre A., Eriksson J., Handelman S.K., Aragaki A., Karasik D., Pramstaller P.P., Kooperberg C., Lacroix A.Z., Larson M.G., Lau K.S., Lorentzon M., Pichler I., Sham P.C., Taliun D., Vandenput L. and Kiel D.P., Meta-analysis Of Genome-wide Association Studies Identifies Two Loci Associated With Circulating Osteoprotegerin Levels., Hum Mol Genet. 2014.


Researcher : Lau VYM
List of Research Outputs

Lee Y.K., Ran X., Lai K.W.H., Lau V.Y.M., Siu D.C.W. and Tse H.F., Generation and Characterization of Patient-SpecificInduced Pluripotent Stem Cell Model for Cardiovascular Disease, Springer Protocols. 2015.


Researcher : Lau WCS
Project Title:Prospective study of the clinical pattern of systemic lupus erythematosus in Hong Kong
Investigator(s):Lau WCS
Department:Medicine
Source(s) of Funding:Other Funding Scheme
Start Date:01/1993


Project Title:Effects of sex hormones on lymphocyte function in systemic lupus erythematosus
Investigator(s):Lau WCS, Mok TMY
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2002


Project Title:A study to evaluate the immunopathology of Severe Acute Respiratory Syndrome
Investigator(s):Lau WCS, Chan YTE, Cheung BMY
Department:Medicine
Source(s) of Funding:VCO SARS Research Fund
Start Date:07/2003


Project Title:Evaluation of the effects of sex hormones on neutrophils and macrophage apoptosis and macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus
Investigator(s):Lau WCS
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2003


Project Title:Dendritic cell function and their effects on B cell activation in systemic lupus erythematosus
Investigator(s):Lau WCS
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:12/2005


Project Title:Interactions between plasmacytoid dendritic cells and T regulatory / interleukin-17 producing T-helper cells in systemic lupus erythematosus
Investigator(s):Lau WCS
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2012


Project Title:The role of plasmacytoid dendritic cells in systemic lupus erythematosus
Investigator(s):Lau WCS, Chan VSF
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:06/2013


Project Title:The role of regulatory microRNAs in plasmacytoid dendritic cell functions in systemic lupus erythematosus immunopathogenesis
Investigator(s):Lau WCS, Chan VSF
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:11/2013


Project Title:Advances in Immunology in Health and Disease
Investigator(s):Lau WCS
Department:Medicine
Source(s) of Funding:Croucher Summer Courses
Start Date:07/2014


Project Title:Validation of a new definition of lupus low disease activity state (LLDAS): Clinical and management implications
Investigator(s):Lau WCS
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2015


List of Research Outputs

Au Y.L.E., Wong R.W.S., Mok T.M.Y., Chung H.Y., Chan Y.T.E. and Lau W.C.S., Disease activity assessment in ankylosing spondylitis in a Chinese cohort: BASDAI or ASDAS?, Clinical Rheumatology . 2014, 33: 1127-1134.
Chan C.Y., Tsang H.H., Lau W.C.S. and Chung H.Y., Prevalence of depressive and anxiety disorders and validation of the Hospital Anxiety and Depression Scale as a screening tool in axial spondyloarthritis patients, International Journal of Rheumatic Diseases. 2014, n/a-n/a.
Chan Y.T.E., Ho H.K., Lai C.K.W., Lau W.C.S., Lau Y.L., Lee T.H., Leung T.F., Wong G.W.K. and Wu Y.Y., Allergy in Hong Kong: an unmet need in service provision and training, Hong Kong Medical Journal. 2015.
Chen Y., Chung H.Y., Zhao C.T., Wong A., Zhen S., Tsang H.H., Lau W.C.S., Tse H.F. and Yiu K.H., Left ventricular myocardial dysfunction and premature atherosclerosis in patients with axial spondyloarthritis, Rheumatology. 2015, 54: 292-301.
Lau W.C.S., APLAR Rheumatoid Arthritis Treatment Recommendations., Annual European Congress of Rheumatology EULAR 2015, Rome, Italy, 9-13 June 2015. 2015.
Lau W.C.S., Co-Editor, Special Issue "Molecular and Cellular Mechanisms in the Pathogenesis of Systemic Lupus Erythematosus". 2015.
Lau W.C.S., How to set up a rheumatology service?, HKARF Rheumatology education for Mainland medical and allied health professionals, Qingyuen Hospital, China, 10-12 April 2015. 2015.
Lau W.C.S., Management of systemic lupus erythematosus., HKARF Rheumatology education for Mainland medical and allied health professionals, Qingyuen Hospital, China, 10-12 April 2015. 2015.
Lau W.C.S., Member, Editorial Board, International Journal of Molecular Sciences. 2015.
Lau W.C.S., Member, The Hong Kong Institute of Allergy. 2015.
Lau W.C.S., Treating to Target in Lupus: A new concept., The Chinese Rheumatic Disease Database and Chinese Systemic Lupus Erythematosus Treatment and Research (CSTAR) 4th Annual Scientific Meeting, Beijing, 17-19 October 2014. 2014.
Lau W.C.S., Treating to target in SLE: a new concept., 15th Malaysian Society for Rheumatology / Singapore Society for Rheumatology Annual Meeting, Kuala Lumpur, 23-24 August 2014. 2014.
Lau W.C.S., Update on the treatment of SLE., 15th Malaysian Society for Rheumatology / Singapore Society for Rheumatology Annual Meeting, Kuala Lumpur, 23-24th August 2014. 2014.
TAM C.Y., Yang W., Lau W.C.S. and Chan V.S.F., Systemic Lupus Erythematosus Patients Exhibit Reduced Expression of CLEC16A Isoforms in Peripheral Leukocytes, International Journal of Molecular Sciences. Basel, Switzerland, MDPI AG, 2015, 16: 14428-14440.
WU H., Lo Y., Luk D., Lau W.C.S., Lu L. and Mok T.M.Y., Alternatively activated dendritic cells derived from systemic lupus erythematosus patients have tolerogenic phenotype and function, Clinical Immunology. 2015, 156: 43-57.
ZHANG J., Zhang L., ZHANG Y., Yang J., Guo M., Sun L., Pan H.F., Hirankarn N., Ying D., ZENG S., Lee T.L., Lau W.C.S., Chan T.M., Leung A.M.H., Mok C.C., Wong S.N., Lee K.W., Ho M.H.K., Lee P.P.W., Chung B.H.Y., Chong C.Y., Wong R.W.S., Mok W.C.L., Wong W.H.S., Tong K.L., Tse N.K.C., LI X.P., Avihingsanon Y., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Shotelersuk V., Ying S.K.S., Fung S.K.S., Lai W.M., Garcia-Barcelo M.M., Cherny S.S., Sham P.C., Yong C., Yang S., Ye D.Q., Zhang X.J., Lau Y.L. and Yang W., Gene-based meta-analysis of GWAS data identifies independent SNPs in ANXA6 as associated with SLE in Asian populations, Arthritis & Rheumatology. 2014.
ZHANG Y., Yang J., ZHANG J., Sun L., Hirankarn N., Pan H.F., Lau W.C.S., Chan T.M., Lee T.L., Leung A.M., Mok C.C., ZHANG L., WANG Y., Shen J.J., Wong S.N., Lee K.W., Ho M.H.K., Lee P.P.W., Chung B.H.Y., Chong C.Y., Wong R.W.S., Mok T.M.Y., Wong W.H.S., Tong K.L., Tse N.K.C., LI X.P., Avihingsanon Y., Rianthavorn P., SDeekajorndej T., Shotelersuk V., Suphapeetiporn K., Shotelersuk V., Ying S.K.Y., Fung S.K.S., Lai W.M., Wong C.M., Ng I.O.L., Sham P.C., Garcia-Barcelo M.M., Cherny S.S., Cui Y., Sham P.C., Yang S., Ye D.Q., Zhang X.J., Lau Y.L. and Yang W., Genome-wide search followed by replication reveals genetic interaction of CD80 and ALOX5AP associated with systemic lupus erythematosus in Asian populations, Annuals of Rheumatic Diseases. 2015.
Zhang Y., ZHANG J., Yang J., WANG Y., ZHANG L., Zuo X., Sun L., Pan H.F., Hirankarn N., WANG T., CHEN R., Ying D., Shen J.J., Lee T.L., Lau W.C.S., Chan D.T.M., Leung A.M.H., Mok C.C., Wong S.N., Lee K.W., Ho M.H.K., Lee P.P.W., Chung B.H.Y., Chong C.Y., Wong R.W.S., Mok T.M.Y., Wong W.H.S., Tong K.L., Tse N.K.C., Li X.P., Avihingsanon Y., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Shotelersuk V., Ying S.K.Y., Fung S.K.S., Lai W.M., Wong C.M., Ng I.O.L., Garcia-Barcelo M.M., Cherny S.S., Tam P.K.H., Sham P.C., Yang S., Ye D.Q., Cui Y., Zhang X.J., Lau Y.L. and Yang W., Meta-analysis of GWAS on two Chinese populations followed by replication identifies novel genetic variants on the X chromosome associated with systemic lupus erythematosus, Human Molecular Genetics. 2015, 24(1): 274-284.
Zhang Y., Wang Y., Yang J., ZHANG J., Sun L., Hirankarn N., Pan C.F., Lau W.C.S., Chan T.M., Lee T.L., Leung A.M.H., Mok C.C., ZHANG L., SHEN J., Wong S.N., Lee K.W., Ho M.H.K., Lee P.P.W., Chung B.H.Y., Chong C.Y., Wong R.W.S., Mok T.M.Y., Wong W.H.S., Tong K.L., Tse N.K., Li X.P., Avihingsanon Y., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Shotelersuk V., Ying S.K., Fung S.K., Lai W.M., Wong C.M., Ng I.O.L., Garcia-Barcelo M.M., Cherny S.S., Tam P.K.H., Sham P.C., Yang S., Ye D.Q., Cui Y., Zhang X.J., Yang W. and Lau Y.L., Meta-analysis of two Chinese populations identifies an autoimmune disease risk allele in 22q11.21 as associated with systemic lupus erythematosus, Arthritis Research & Therapy. 2015, 17: 67.


Researcher : Lee CHP
List of Research Outputs

Lee C.H.P. and Lam K.S.L., Biomarkers of progression in diabetic nephropathy: The past, present and future, Journal of Diabetes Investigation. 2015, 6: 247-249.
Lee C.H.P., Hui Y.L.E., Woo Y.C., Yeung C.Y., Chow W.S., Yuen M.A.M., Fong H.Y., Xu A. and Lam K.S.L., Circulating Fibroblast Growth Factor 21 Levels Predict Progressive Kidney Disease in Subjects With Type 2 Diabetes and Normoalbuminuria, The Journal of Clinical Endocrinology & Metabolism. 2015, 100: 1368-1375.
Lee C.H.P., Woo Y.C., Fong C., Pau H.Y.N., Lam K.S.L. and Tan K.C.B., Validation of the Pooled Cohort Equations in a Hong Kong Chinese Cohort., 17th International Symposium on Atherosclerosis, Amsterdam, May 2015.
Woo Y.C., Cheung B.M.Y., Yeung C.Y., Lee C.H.P., Hui Y.L.E., Fong H.Y., Tso A.W.K., Tam S. and Lam K.S.L., Cardiometabolic risk profile of participants with prediabetes diagnosed by HbA1c criteria in an urban Hong Kong Chinese population over 40 years of age , Diabetic Medicine. 2015, n/a-n/a.


Researcher : Lee SWL
List of Research Outputs

Kong S.L., Lee S.W.L., Lui G.C.S., Chan W.S., Fok A.K.T., Lee H.P. and Wu K.Y.K., VALIDATION OF ACCURACY OF HOME BLOOD PRESSURE MONITORING DEVICES BY BLAND AND ALTMAN LIMITS OF AGREEMENT AND METHOD OF VARIANCE ESTIMATES RECOVERY, Journal of the American College of Cardiology. 2015, 65: A1406.
Lee S.W.L., Lam S.C.C., Kong S.L., Chan K.W.K., Tam C.C., Wong K.L., Wong A.Y.T., Yung A.S.Y., Shea C.P., Zhang L. and Wu K.Y.K., TCT-367 2-Year Sequential OCT Follow-up Findings and 3-Year Clinical Outcomes of the New Dual Therapy Endothelial Progenitor Cell Capturing Sirolimus-eluting COMBO Stent: The EGO-COMBO Study, Journal of the American College of Cardiology. 2014, 64: B107.


Researcher : Lee YK
Project Title:The role of LMNA/C in regulation of cardiac nodal cell survival and electrophysiological function
Investigator(s):Lee YK, Tse HF, Siu DCW
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:01/2015


List of Research Outputs

Lee Y.K., Ran X., Lai K.W.H., Lau V.Y.M., Siu D.C.W. and Tse H.F., Generation and Characterization of Patient-SpecificInduced Pluripotent Stem Cell Model for Cardiovascular Disease, Springer Protocols. 2015.
Lee Y.K., Ng K.M. and Tse H.F., Modeling of Human Cardiomyopathy with Induced Pluripotent Stem Cells, Journal of Biomedical Nanotechnology. 2014, 10: 2562-2585.
XU J., Lee Y.K., Wang Y. and Tse H.F., Therapeutic Application of Endothelial Progenitor Cells for Treatment of Cardiovascular Diseases, Current Stem Cell Research & Therapy. 2014, 401-414 (14).


Researcher : Lee YKM
Project Title:European Respiratory Society's 24th International Congress; Intermittent hypoxia-induced adipocyte derived secretory products cause inflammatory responses in endothelial cells in vitro
Investigator(s):Lee YKM
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:09/2014
Completion Date:09/2014


Project Title:Interaction of intermittent hypoxia and obesity on endothelium-dependent contraction
Investigator(s):Lee YKM, Ip MSM
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:03/2015


List of Research Outputs

Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Intermittent hypoxia-induced adipocyte derived secretory products cause inflammatory responses in endothelial cells in vitro, Eur Respir J. 2014, 44: Suppl. 58, 4447.
Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Intermittent hypoxia-induced adipocyte derived secretory products cause inflammatory responses in endothelial cells in vitro, European Respiratory Society International Congress 2014, Munich, Germany, Sep 2014. Abst. 4447.
WANG Y., Yeung S.C., Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Intermittent hypoxia accelerates adipogenic differentiation in human subcutaneous preadipocytes in vitro, Am J Respir Crit Care Med. 2015, 191: A2704.


Researcher : Leung AYH
Project Title:Provision of free alemtuzumab (anti-CD52) to patients with chronic lymphocytic leukemia refractory to conventional chemotherapy
Investigator(s):Leung AYH, Kwong YL
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:11/2007


Project Title:Detection of WU and KI polyomaviruses from patients with acute respiratory tract infections in Hong Kong
Investigator(s):Leung AYH, Kwong YL
Department:Medicine
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:01/2009


Project Title:Provision of free service for serum polyoma BK virus quantification to kidney transplant recipients in Hong Kong
Investigator(s):Leung AYH, Kwong YL, Tang SCW
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2009


Project Title:Provision of free molecular tests for patients with acute myeloid leukemia with normal cytogenetics
Investigator(s):Leung AYH
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2010


Project Title:Provision of free sorafenib for patients with refractory or relapsed acute myeloid leukemia to bridge them to curative bone marrow transplantation
Investigator(s):Leung AYH, Kwong YL
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:07/2010


Project Title:Is sox7 a tumour suppressor in acute myeloid leukemia?
Investigator(s):Leung AYH
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2012


Project Title:Study of Microglia and Myeloid Leukemia in Zebrafish
Investigator(s):Leung AYH
Department:Medicine
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:05/2013


Project Title:A novel role of ADP-ribosylation factors-like 4a (arl4a) in definitive hematopoiesis
Investigator(s):Leung AYH
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:07/2013


Project Title:Provision of free Sorafenib for patients with refractory or relapsed acute myeloid leukemia to bridge them to curative bone marrow transplantation
Investigator(s):Leung AYH
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2014


Project Title:Development of Cell Manipulation Tools for Probing Functional Mechanism of Hematopoietic Cells: Robotics, Optical tweezers, and Hematopoiesis
Investigator(s):Leung AYH
Department:Medicine
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2014


List of Research Outputs

HU J., WONG N.K., YE S., Chen X., LU M., ZHAO Q., GUO Y., Ma C.H., Leung A.Y.H., Shen J. and Yang D., Fluorescent Probe HKSOX-1 for Imaging and Detection of Endogenous Superoxide in Live Cells and In VivoJournal of the American Chemical Society, Journal of the American Chemical Society. 2015, 137: 6837-6843.
SHI X., HE B., Ma C.H., GUO Y., Chi Y., Zhang W., Zhang Y., Wen Z., Cheng T. and Leung A.Y.H., Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish, Blood. 2015, 125: 2974-2984.
Singh G.H.H., Man C.H., Ip H.W., Choi W.L., Chow H.C.H., Kwong Y.L. and Leung A.Y.H., Azacitidine as post-remission consolidation for sorafenib-induced remission of Fms-Like Tyrosine Kinase-3 internal tandem duplication positive acute myeloid leukemia, Haematologica. 2015.
Singh G.H.H., Hwang Y.Y.G., Chan T.S.Y., Chan C.C., Chan C.H.Y., Liu H.S.Y., Mak V., Lin S.Y., Lau C.K., Leung A.Y.H., Lie A.K.W. and Kwong Y.L., Clinicopathologic Features and Outcome of Chinese Patients with Myelofibrosis, 56th ASH Annual Meeting and Exposition, San Francisco, CA.. Blood, 2014, 124 (21).
Singh G.H.H., Chan T.S.Y., Hwang Y.Y.G., Leung A.Y.H., Tse E.W.C. and Kwong Y.L., Clofarabine And High-dose Cytarabine Arabinoside (clara) For Primary Refractory Or Relapsed Acute Myeloid Leukaemia – A Prospective Follow-up Study Of 60 Patients, 20th Congress of the European Haematology Association, Vienna, 11 - 15 June 2015.. 2015.
Singh G.H.H., Ip H.W., Pang A.W.K., Sum C.Y., Leung A.Y.H. and Kwong Y.L., FLT3 internal tandem duplication in acute promyelocytic leukemia: central nervous system relapse, Annals of Hematology. 2014.
Singh G.H.H., Leung A.Y.H., Tse E.W.C. and Kwong Y.L., Relapse Characteristics And Risk Factors For Central Nervous System Involvement In Acute Promyelocytic Leukaemia In The Oral Arsenic Trioxide Era – A 13-year Follow-up Study, 20th Congress of the European Haematology Association, Vienna, June 11 - 15, 2015.. Haematologica, 2015.
Weng J.Z., Kong M.C.W., Ren L., Karakikes I., Geng L., HE J., Chow M.Z.Y., Mok C.F., Keung W.W.Y., Chow C.H., Leung A.Y.H., Hajjar R.J., Li R.A. and Chan C.W.Y., A simple, cost-effective but highly efficient system for deriving ventricular cardiomyocytes from human pluripotent stem cells. PMID: 24564569 , Stem Cells & Development. 2014, 23(14): 1704-16.


Researcher : Leung JCK
Project Title:Macrophage–Myofibroblast-Transition in Organ Fibrosis: Molecular Mechanisms and Clinical Implications
Investigator(s):Leung JCK
Department:Medicine
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2013


Project Title:The role of kidney injury molecule in the reparative process of injured kidney tubular epithelial cells
Investigator(s):Leung JCK
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2014


List of Research Outputs

LI R., Yiu W.H., Wu H., LIN M., WONG W.L.D., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., BMP7 Reduces Tubular Inflammation and Oxidative Stress in Diabetic Nephropathy, J Am Soc Nephrol. 2014, 25: 216A.
LI R., Yiu W.H., Wu H., WONG W.L.D., Chan Y.Y., LIN M., Leung J.C.K., Lai K.N. and Tang S.C.W., BMP7 reduces inflammation and oxidative stress in diabetic tubulopathy, Clinical Science [IF 5.629]. 2015, 128(4): 269-280.
Lai K.N., Leung J.C.K. and Tang S.C.W., The treatment of IgA nephropathy, Kidney Dis . 2015.
Lim A.I., Chan Y.Y., Tang S.C.W., Lai K.N. and Leung J.C.K., Albumin and glycated albumin activate KIM-1 release in tubular epithelial cells through distinct kinetics and mechanisms, Inflammation Research [Epub ahead of print]. 2014.
Yiu W.H., WONG W.L.D., Leung J.C.K., Chan Y.Y., Lai K.N. and Tang S.C.W., Thrombin Induces Epithelial-Mesenchymal Transition Through the Activation of PAR-1 in Tubular Epithelial Cells, J Am Soc Nephrol. 2014, 25: 730A.


Researcher : Leung KP
List of Research Outputs

Man M.S.C., HUNG H.B., Ng R., Yu X.C., Cheung H., Fung P.M., Li L.S.W., Leung K.P., Leung K.P., Tsang W.K., Ziea E., Wong V.C.W. and Zhang Z., A pilot controlled trial of a combination of dense cranial electroacupuncture stimulation and body acupuncture for post-stroke depression, In: Tom Rowles, BMC Complementary and Alternative Medicine. London, UK, BioMed Central, 2014, 14: 255.


Researcher : Leung RCY
List of Research Outputs

Chiu J.W.Y., Wong H.Y.H., Leung R.C.Y., Pang R.W.C., Cheung T.T., Fan S.T., Poon R.T.P. and Yau T.C.C., Advanced Pancreatic Cancer: Flourishing Novel Approaches in the Era of Biological Therapy, Oncologist. 2014.
Chiu W.Y.J., Leung R.C.Y., Suen T.K.D., Chen T.H.C., Chow C.Y.L., Kwok G., Wong H., Cheung P., Yau T.C.C. and Kwong A., A phase II study of neoadjuvant chemotherapy using combined taxane, anthracycline, and cyclophosphamide in high risk HER2-negative locally advanced breast cancer (Abstract & Oral Presentation), Global Breast Cancer Conference 2015 and the 4th International Breast Cancer Symposium, Jeju Island, Korea, 23-25 April 2015.
Chiu W.Y.J., Leung R.C.Y., Suen T.K.D., Chen T.H.C., Chow C.Y.L., Kwok G., Wong H., Cheung P. and Yau T.C.C., KBCF Scholarship on "A phase II study of neoadjuvant chemotherapy using combined taxane, anthracycline, and cyclophosphamide in high risk HER2-negative locally advanced breast cancer", Global Breast Cancer Conference 2015 and the 4th International Breast Cancer Symposium, Jeju Island, Korea, 23-25 April 2015. 2015.
Chiu W.Y.J., Yau T.C.C., Cheung T.T., Chan A.C.Y., Chok K.S.H., Dai W.C., Leung R.C.Y., Chan S.C. and Lo C.M., Use of Sorafenib in recurrent hepatocellular carcinoma (HCC) after liver transplantation, Gastrointestinal Cancers Symposium, American Society of Clinical Oncology, San Francisco, USA, 15-17 January 2015.


Researcher : Leung WK
Project Title:A prospective randomized trial to compare the safety and immunogenicity of intradermal and intramuscular influenza vaccines in patients with inflammatory bowel disease in Hong Kong
Investigator(s):Leung WK, Hung IFN, Chan KH
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2013


Project Title:Molecular characterization of gastric microbiome in individuals at different stages of H. pylori associated gastric carcinogenesis cascade
Investigator(s):Leung WK, Sham PC
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:11/2013


Project Title:Detection of methylated Septin 9 DNA in blood for diagnosis, prognosis and surveillance of patients with colorectal cancer
Investigator(s):Leung WK, Shin VY
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:03/2014


List of Research Outputs

Chan E.W., LAU C.Y., Leung W.K., Mok M.T.C., HE Y., Tong T.S.M. and Wong I.C.K., Effectiveness of Gastroprotective Agents on Prevention of Dabigatran Related Gastrointestinal Bleeding: A Population-Based Restrospective Cohort Study, ISOP 2014, Tianjin, China, 19-22 October (oral). 2014.
Chan E.W., Lau C.Y., Leung W.K., Mok M.T.C., He Y., Tong S.M. and Wong I.C.K., Prevention of Dabigatran-related Gastrointestinal Bleeding With Gastroprotective Agents: A Population-Based Study, Gastroenterology. 2015.
HE Y., Chan E.W., Man K.C.K., LAU C.Y., Leung W.K., Ho L.M. and Wong I.C.K., Dosage Effects of Histamine-2 Receptor Antagonist on the Primary Prophylaxis of Non-Steroidal Anti-Inflammatory Drug (NSAID)-Associated Peptic Ulcers: A Retrospective Cohort Study, Drug Safety. 2014, 37: 711-721.
He Y., Chan E.W., Leung W.K., Anand S. and Wong I.C.K., Systematic review with meta-analysis: the association between the use of calcium channel blockers and gastrointestinal bleeding, Alimentary Pharmacology & Therapeutics. 2015, 41: 1246-1255.
Hung I.F.N., Liu S.H.K., Tan V.P.Y., Hsu A.S.J., Seto W.K.W., Tong S.M. and Leung W.K., Seven-day Rifabutin Containing Triple Therapy Versus Seven-day Levofloxacin Containing Quadruple Therapy as Second-line Treatment for Helicobacter pylori in Chinese Patients: an Open Label, Randomized Trial, Digestive Disease Week 2015. (Oral presentation). 2015, S149.
LAU C.Y., Chan E.W., Wong I.C.K., HE Y., Tong S.M. and Leung W.K., Use of gastroprotective agents and risk of dabigatran associated gastrointestinal bleeding: a population-based retrospective cohort study, United European Gastroenterology (UEG) Week,18-22 October, Vienna. 2014.
Leung W.K., Appropriate use of biologics in IBD, 8th Wuhan IBD Summit, Wuhan, China. 2014.
Leung W.K., Best Practice on ulcerative colitis management, Dinner Symposium organized by Ferring Singapore, Singapore. 2015.
Leung W.K., Committee Member, The Licentiate Committee, Hong Kong Medical Council . 2014.
Leung W.K., Council Member, Hong Kong Society of Gastroenterology. 2014.
Leung W.K., Course Director of “ERCP and EUS Workshop”, Departments of Medicine and Surgery, University of Hong Kong. 2015.
Leung W.K., Course Director of “IBD Workshop”, Department of Medicine, University of Hong Kong. 2015.
Leung W.K., Diagnosis of small bowel tumor with capsule endoscopy, Advanced Endoscopy Conference of the Digestive Endoscopy Society of Taiwan, Taichung, Taiwan. 2015.
Leung W.K., Chen W.Q., Gu L., Long D. and Law W.L., Distributions of colorectal cancer in two chinese cities with contrasting colorectal cancer epidemiology, Journal of Gastroenterology and Hepatology. 2015, 62: 748-751.
Leung W.K., Editorial Board Membe, Helicobacter. 2014.
Leung W.K., Editorial Board Member, Best Practice & Research – Clinical Gastroenterology. 2015.
Leung W.K., Editorial Board Member, Chinese Journal of Digestion. 中华消化杂志, 2014.
Leung W.K., Editorial Board Member, Chinese Journal of Digestion. 2015.
Leung W.K., Editorial Board Member, Helicobacter. 2015.
Leung W.K., Editorial Board Member, Hepatogastroenterology. 2015.
Leung W.K., Editorial Board Member, Journal of Digestive Diseases. 2015.
Leung W.K., Editorial Board Member, Journal of the Society of Physicians of Hong Kong. 2015.
Leung W.K., IBD and Pregnancy, 2014 Shenzhen IBD Forum, China. 2014.
Leung W.K., IBD and pregnancy, Hong Kong IBD Society Workshop. 2015.
Leung W.K., Impact of IBS on IBD, Inaugural Asian Expert Group on Irritable Bowel Syndrome (AEGIS) Meeting, Guangzhou, China. 2014.
Leung W.K., Indication extrapolation: Clinical considerations, Regional Advisory Board Meeting on Biosimilars organized by Abbvie, Taipei, Taiwan. 2014.
Leung W.K., Inflammatory Bowel Disease, Exhibition on Gastrointestinal Health organized by the HKU Medical Society. 2014.
Leung W.K., Journal Reviewer, American Journal of Gastroenterology. 2014.
Leung W.K., Journal Reviewer, Gastroenterology. 2014.
Leung W.K., Journal Reviewer, Gut. 2014.
Leung W.K., Journal Reviewer, Journal of Gastroenterology & Hepatology. 2014.
Leung W.K., Journal Reviewer, Lancet. 2014.
Leung W.K., Journal Reviewer, Lancet Oncology. 2014.
Leung W.K., Journal Reviewer, Lancet Oncology. 2015.
Leung W.K., Management issues in NOAC-related GI Bleeding, Anticoagulants Advisory Board Meeting, oraganized by Boehringer Ingelheim. 2014.
Leung W.K., Management of Ulcerative Colitis, Annual Philippines Society of Gastroenterology Meeting 2015, Manila, Philippines. 2015.
Leung W.K., Management of bleeding esophageal varices, the Annual Scientific Meeting of the Macao Society of Gastroenterology and Hepatology, Macau. 2014.
Leung W.K., Medical management in Crohn’s Disease, “Decision Making in Digestive Disease” organized by the Association of Macau Portuguese Speaking Physicians, Macau. 2015.
Leung W.K., Member, Expert Panel for Review of Scientific Research Projects, National Health and Family Planning Commission of People’s Republic of China. 2015.
Leung W.K., Member, Grant Review Board, Health and Medical Research Fund, Hong Kong SAR Government. 2015.
Leung W.K., New Progress in Treatment of Irritable Bowel Syndrome, Chinese Society of Gastroenterology, Guangzhou and Shanghai, China. 2014.
Leung W.K., New Progress in Treatment of Irritable Bowel Syndrome, Macau Society of Gastroenterology & Hepatology, Macau. 2014.
Leung W.K., Non-invasive Screening of Colorectal Cancer, Hong Kong Pathology Forum. 2015.
Leung W.K., Oral and Upper GI Crohn’s disease, ME lecture of the Singapore General Hospital, Singapore. 2015.
Leung W.K., Organization of IBD Cohort Study: Experience in Hong Kong, Annual Meeting of KASID 2015, Seoul, Korea. 2015.
Leung W.K., Overview of IBD Epidemiology in Asia, Chongqing University, China. 2015.
Leung W.K., Post-prandial distress syndrome, The 13th Annual Scientific Meeting of the Hong Kong Society of Gastrointestinal Motility. 2014.
Leung W.K., Prevention of colorectal cancer in inflammatory bowel disease: Drugs or Endoscopy, Multi-specialty Medical Mega Conference 2015. 2015.
Leung W.K., RFA for gastric dysplasia and metaplasia in Hong Kong, the 1st Coviden GI Solutions Asia Forum, Shanghai, China. 2014.
Leung W.K., Screening and surveillance of colorectal cancer in the elderly: Risks and Benefits, 10th International Symposium on Healthy Aging, HKU. 2015.
Leung W.K., The role of genetic polymorphisms in H. pylori treatment resistance, Pariet Dinner Symposium, Shanghai, China. 2014.
Leung W.K., Tong D.K.H., Leung S.Y., Chan S.Y., Tong S.M., Ho R.S.L., Chu K.M. and Law S.Y.K., Treatment of gastric metaplasia or dysplasia by endoscopic radiofrequency ablation: A pilot study, Hepato-Gastroenterology. 2015, 62: 52-55.
Leung W.K., Update on Inflammatory Bowel Disease, CME Program of Surgeons, Hong Kong Baptist Hospital. 2014.
Ooi C.J., Hilmi I., Makharia G.K., Gibson P.R., Fock K.M., Ahuja V., Ling K.L., Lim W.C., Thia K.T., Wei S.C., Leung W.K., Koh P.K., Gearry R.B., Goh K.L., Ouyang Q., Sollano J., Manatsathit S., de Silva H.J., Rerknimitr R., Pisespongsa P., Abu Hassan M.R., Sung J., HIbi T., Boey C.C.M., Moran N., Leong R.W.L. and Asia Pacific Association of Gastroenterology (APAGE) Working Group on Inflammatory Bowel Disease .., The Asia Pacific Consensus Statements on Crohn's Disease Part 1: definition, diagnosis and epidemiology, Journal of Gastroenterology and Hepatology. 2015, n/a-n/a.
Ooi C.J., Hilmi I., Makharia G.K., Gibson P.R., Fock K.M., Ahuja V., Ling K.L., Lim W.C., Thia K.T., Wei S.C., Leung W.K., Koh O.K., Gearry R.B., Goh K.L., Ouyang Q., Sollano J., Manatsathit S., de Silva H.J., Rerknimitr R., Pisespongsa P., Abu Hassan M.R., Song J., Hibi T., Boey C.C.M., Moran N. and Asia Pacific Association of Gastroenterology (APAGE) Working Group on Inflammatory Bowel Disease .., The Asia Pacific Consensus Statements on Crohn's Disease Part 2: Management, Journal of Gastroenterology and Hepatology. 2015, n/a-n/a.
Rex D.K., Adler S.N., Aisenberg J., Burch W.C., Carretero C., Chowers Y., Fein S.A., Fern S.E., Fernandez-Urien Sainz I., Fich A., Gal E., Horlander Sr J.C., Isaacs K.L., Kariv R., Lahat A., Leung W.K., Malik P.R., Morgan M., Papageorgiou N., Romeo D.R., Shah S.S. and Waterman M., Accuracy of Capsule Colonoscopy in Detecting Colorectal Polyps in a Screening Population, Gastroenterology. 2015, 148: 948-957.e2.
Seto W.K.W., Lau E.H.Y., Wu J.T.K., Hung I.F.N., Leung W.K., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., An epidemiological association between the trends of nucleoside analogue prescription and liver cancer incidence from 1999 to 2012 in Hong Kong, China, Poster presentation at the International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2015, 62(Suppl 2): S435.
Tan V.P.Y., Wong B.C.Y., Wong R.W.M., Leung W.K., Tong D.K.H., Yuen R.M.F. and Fass R., Gastroesophageal reflux disease: cross-sectional study demonstrating rising prevalence in a Chinese population, J Clin Gastroenterol. 2015, Epub ahead of print.
Tan V.P.Y., Liu S.H.K., Lam Y.F., Hung I.F.N., Yuen R.M.F. and Leung W.K., Rifaximin for the Treatment of Functional Dyspepsia: A Double-Blind Randomized Placebo-Controlled Trial., Digestive Diseases Week 2015.
Teoh A.Y.B., Chiu P.W.Y., Chan S.Y., Cheung F.K.Y., Chu K.M., Kao S.S., Lai T.W., Lau C.W., Law S.Y.K., Leung C.T.L., Leung W.K., Tong D.K.H. and Tsang S.H., Hospital Authority audit of the outcome of endoscopic resection of superficial upper gastro-intestinal lesions in Hong Kong, Hong Kong Medical Journal. 2015, 21(3): 224-231.
Teoh A.Y.B., Chiu P.W.Y., Cheung F.Y.K., Chu K.M., Kao S., Law S.Y.K., Tsang S.H., Lai T.W., Lau C.W., Leung C.T.K. and Leung W.K., Region wide audit in the outcomes of endoscopic resection of superficial upper gastrointestinal lesions in Hong Kong. A multi-centered review, Digestive Disease Week 2014, Orlando, USA, 18-21 May 2014.


Researcher : Leung YH
List of Research Outputs

Cheung T.T., Cheung C.L., Tan K.C.B., Leung Y.H. and Cheung B.M.Y., People With Peripheral Arterial Disease And Diabetes Are Associated With Clinically Significant Weakness , International conference on diabetes and metabolism. 2014.


Researcher : Li FYL
List of Research Outputs

KWOK H.M., Cheng K.Y., Li F.Y.L., Chan Y.C.C., Hoo R.L.C., Ye D., Xu A. and Lam K.S.L., Inactivation of c-Jun N-terminal Kinase in Adipose Tissue Alleviates Atherosclerosis in Diet-induced Obese ApoE-deficient Mice, 83rd European Atherosclerosis Society Congress. 2015.


Researcher : Li G
Project Title:Volume-sensitive chloride current and cell volume regulation in human atrial myocytes
Investigator(s):Li GR, Lau CP, Chiu SW, Tse HF
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2001


Project Title:Roles of Functional Ion Channels in Migration and Proliferation of Human Cardiac c-Kit+ Cells
Investigator(s):Li GR, Cheng LC, Li X
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:11/2012
Completion Date:01/2015


List of Research Outputs



Researcher : Li GR
Project Title:Volume-sensitive chloride current and cell volume regulation in human atrial myocytes
Investigator(s):Li GR, Lau CP, Chiu SW, Tse HF
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2001


Project Title:Roles of Functional Ion Channels in Migration and Proliferation of Human Cardiac c-Kit+ Cells
Investigator(s):Li GR, Cheng LC, Li X
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:11/2012
Completion Date:01/2015


List of Research Outputs

Chen K., Liu H., Yang L., Jin M.W. and Li G.R., SKF-96365 strongly inhibits voltage-gated sodium current in rat ventricular myocytes, Pflügers Archiv - European Journal of Physiology. 2014.
Yang L., Liu H., Sun H. and Li G.R., Intravenous Anesthetic Propofol Inhibits Multiple Human Cardiac Potassium Channels, Anesthesiology. 2014, 122(3): 571-84.
Yu W., Wang Y., Zhou D.X., Zhao L.M., Li G.R. and Deng X.L., Equol is Neuroprotective During Focal Cerebral Ischemia and Reperfusion that Involves p-Src and gp91phox, Current Neurovascular Research. 2014, 11: 367-377.


Researcher : Li H
List of Research Outputs

Ye D., Wang Y., Li H., Jia W., Man K., Lo C.M., Wang Y., Lam K.S.L. and Xu A., Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1α-mediated antioxidant capacity in mice, Hepatology. 2014, 60: 977-989.


Researcher : Li LSW
List of Research Outputs

CHENG K.Y., Chan K.M.K., CHIU M.Y., Wong C.S., Li L.S.W. and Cheung R.T.F., Effects of repetitive transcranial magnetic stimulation on post-stroke survivors' swallowing functions, 2nd Australasian and Asia Pacific Laryngology Conference 2014.
Chan Y.H., Lau K.K., Yiu K.H., Li L.S.W., Tam S., Lam T.H., Lau C.P., Siu D.C.W., Cheung B.M.Y. and Tse H.F., Vascular protective effects of statin-related increase in serum 25-hydroxyvitamin D among high-risk cardiac patients, Journal of Cardiovascular Medicine. 2015, 16: 51-58.
Chan Y.H., Lau G.K.K., Yiu K.H., Li L.S.W., Tam S., Lam T.H., Lau C.P., Siu D.C.W., Cheung B.M.Y. and Tse H.F., Vascular protective effects of statin-related increase in serum 25-hydroxyvitamin D among high-risk cardiac patients, Journal of Cardiovascular Medicine (Hagerstown). 2015.
Man M.S.C., HUNG H.B., Ng R., Yu X.C., Cheung H., Fung P.M., Li L.S.W., Leung K.P., Leung K.P., Tsang W.K., Ziea E., Wong V.C.W. and Zhang Z., A pilot controlled trial of a combination of dense cranial electroacupuncture stimulation and body acupuncture for post-stroke depression, In: Tom Rowles, BMC Complementary and Alternative Medicine. London, UK, BioMed Central, 2014, 14: 255.


Researcher : Li OY
List of Research Outputs

Lau G.K.K., Wong Y.K., Teo K.C., Li O.Y., Chan J., Chan S., Cheung R., Wong E., Wong E., Ho S.L., Mak H.K.F. and Rothwell P.M., Clinical correlates and prognostic implications of cerebral microbleeds detected by susceptibility weighted imaging in Chinese with ischaemic stroke, 10th International Symposium of Healthy Aging. 2015.
Lau G.K.K., Wong Y.K., Teo K.C., Li O.Y., Chan J., Chan S., Cheung R., Wong E., Wong E., Ho S.L., Mak H.K.F. and Rothwell P.M., Clinical correlates and prognostic implications of cerebral microbleeds detected by susceptibility weighted imaging in Chinese with ischaemic stroke, European Stroke Organisation Conference. 2015.
Lau G.K.K., Chan L.K., Li O.Y., Yuen T.K., Wong Y.K., Chan K.H., Chan J.F.W., Chang S.K.R., Cheung R.T.F., Doherty I., Ho S.L., Hon F.K.S., Kwan S.K.J., Lee R., Leung G.K.K., Mak W., Mak H.K.F., Shih K.C. and Tsang C.O.A., Establishing an eLearning Platform in Clinical Neurosciences, East-West Alliance Global Symposia 2014.
Lau G.K.K., Wong Y.K., Chan Y.H., Li O.Y., Lee P.Y.S., Yuen G.G., Wong Y.K., Tong S., Wong D. and Chan K.H., Mediterranean-Style Diet Is Associated With Reduced Blood Pressure Variability and Subsequent Stroke Risk in Patients With Coronary Artery Disease, American Journal of Hypertension. 2015, 28: 501-507.


Researcher : Li RA
Project Title:Cell-based Heart Regeneration
Investigator(s):Li RA, Boheler KR, Chan BP, Chan CWY, Chan GCF, Chien KR, Lee HC, Yue J, Ng RK, Ngan AHW
Department:Medicine
Source(s) of Funding:Theme-based Research Scheme
Start Date:09/2011


Project Title:Human WT1 epicardial progenitor cells
Investigator(s):Li RA
Department:Physiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2013


Project Title:Stem Cell and Regenerative Medicine
Investigator(s):Li RA, Chan GCF, Tse HF
Department:Physiology
Source(s) of Funding:Seed Funding for Strategic Research Theme
Start Date:06/2013


Project Title:Engineering Calcium Homeostasis of hESC-derived cardiomyocytes
Investigator(s):Li RA
Department:Physiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:07/2013


Project Title:Ontogenic combinatorial conditioning of 3D human pluripotent stem cell ventricular models for facilitated maturation
Investigator(s):Li RA
Department:Physiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:07/2014


Project Title:International Society for Stem Cell Research 2015 Annual meeting; IMMUNOSUPPRESSIVE EFFECTS OF HUMAN PLURIPOTENT STEM CELL – DERIVED VENTRICULAR CARDIOMYOCYTES TOWARD HUMAN DENDRITIC CELLS
Investigator(s):Li RA
Department:LKS Medical Faculty
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2015




Researcher : Li W
List of Research Outputs

Chan P.H.M., Li W., Hai S.H.J.J., Tse H.F. and Siu D.C.W., Impact of Antithrombotic Therapy in Atrial Fibrillation on the Presentation of Coronary Artery Disease, PLOS ONE. 2015, 10: e0131479.


Researcher : Li X
List of Research Outputs

LI X., Michaeloudes C., Zhang Y., Lian Q., Mak J.C.W., Bhavsar P.K. and Chung K., Oxidative stress-induced mitochondria alteration in human airway smooth muscle cells and mesenchymal stem cells, Am J Respir Crit Care Med. 2015, 191: A5544.
LIANG Y., LI X., Zhang Y., Lian Q. and Mak J.C.W., Amelioration of cigarette smoke-induced cardiac dysfunction and inflammation by mesenchymal stem cells., The 18th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, Hong Kong, 1 November 2014. In Journal of the Hong Kong College of Cardiology, 2014, v. 22 n. 2, p. 49, abstract no. OP2. 2014.
LIANG Y., LI X., Zhang Y., ZHEN Z., Yeung S.C., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Amelioration of cigarette smoke-induced cardiac dysfunction and inflammation by mesenchymal stem cells, J HK Coll Cardiol. 2014, 22: 49.
LIANG Y., LI X., Zhang Y., ZHEN Z., Yeung S.C., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Outstanding Oral presentation - Amelioration of cigarette smoke-induced cardiac dysfunction and inflammation by mesenchymal stem cells , 18th Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine. 2014.
Li X., Zhang Y., Yeung S.C., Liang Y., Li X., Ding Y., Ip M.S.M., Tse H.F., Mak J.C.W. and Lian Q., Mitochondrial transfer of induced pluripotent stem cells-derived MSCs to airway epithelial cells attenuates cigarette smoke-induced damage, American Journal of Respiratory Cell and Molecular Biology. 2014, 51(3): 455-465.
WANG B., Cheng K.Y., Li X., Lam K.S.L. and Xu A., Hypothalamic APPL2 combats against obesity by promoting adaptive thermogenesis in white adipose tissues, EMBL Symposium: Translating Diabetes.. 2015.
WANG B., Cheng K.Y., Li X., Li A., Lam K.S.L. and Xu A., The Role of Hypothalamic APPL2 in Regulation of Energy Expenditure in Adipose Tissues, 2015 Asia Pacific obesity and diabetes symposium.. 2015.
WANG B., Cheng K.Y., Li X., Li A., Lam K.S.L. and Xu A., The hypothalamic APPL2 as a novel regulator of energy homeostasis in adipose tissues, The 10th International Symposium on Healthy Aging 2015. A Decade of Positive Aging. 2015.. 2015.
Zhang Y., LIANG X., Liao S., Wang W., Wang J.J., LI X., Ding Y., LIANG Y., GAO F., Yang M., Fu Q., Xu A., Chai Y.H., He J., Tse H.F. and Lian Q., Potent Paracrine Effects of human induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Attenuate Doxorubicin-induced Cardiomyopathy, Scientific Reports. 2015, 5: 11235.


Researcher : Li X
List of Research Outputs

LI X., Michaeloudes C., Zhang Y., Lian Q., Mak J.C.W., Bhavsar P.K. and Chung K., Oxidative stress-induced mitochondria alteration in human airway smooth muscle cells and mesenchymal stem cells, Am J Respir Crit Care Med. 2015, 191: A5544.
LIANG Y., LI X., Zhang Y., Lian Q. and Mak J.C.W., Amelioration of cigarette smoke-induced cardiac dysfunction and inflammation by mesenchymal stem cells., The 18th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, Hong Kong, 1 November 2014. In Journal of the Hong Kong College of Cardiology, 2014, v. 22 n. 2, p. 49, abstract no. OP2. 2014.
LIANG Y., LI X., Zhang Y., ZHEN Z., Yeung S.C., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Amelioration of cigarette smoke-induced cardiac dysfunction and inflammation by mesenchymal stem cells, J HK Coll Cardiol. 2014, 22: 49.
LIANG Y., LI X., Zhang Y., ZHEN Z., Yeung S.C., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Outstanding Oral presentation - Amelioration of cigarette smoke-induced cardiac dysfunction and inflammation by mesenchymal stem cells , 18th Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine. 2014.
Li X., Zhang Y., Yeung S.C., Liang Y., Li X., Ding Y., Ip M.S.M., Tse H.F., Mak J.C.W. and Lian Q., Mitochondrial transfer of induced pluripotent stem cells-derived MSCs to airway epithelial cells attenuates cigarette smoke-induced damage, American Journal of Respiratory Cell and Molecular Biology. 2014, 51(3): 455-465.
WANG B., Cheng K.Y., Li X., Lam K.S.L. and Xu A., Hypothalamic APPL2 combats against obesity by promoting adaptive thermogenesis in white adipose tissues, EMBL Symposium: Translating Diabetes.. 2015.
WANG B., Cheng K.Y., Li X., Li A., Lam K.S.L. and Xu A., The Role of Hypothalamic APPL2 in Regulation of Energy Expenditure in Adipose Tissues, 2015 Asia Pacific obesity and diabetes symposium.. 2015.
WANG B., Cheng K.Y., Li X., Li A., Lam K.S.L. and Xu A., The hypothalamic APPL2 as a novel regulator of energy homeostasis in adipose tissues, The 10th International Symposium on Healthy Aging 2015. A Decade of Positive Aging. 2015.. 2015.
Zhang Y., LIANG X., Liao S., Wang W., Wang J.J., LI X., Ding Y., LIANG Y., GAO F., Yang M., Fu Q., Xu A., Chai Y.H., He J., Tse H.F. and Lian Q., Potent Paracrine Effects of human induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Attenuate Doxorubicin-induced Cardiomyopathy, Scientific Reports. 2015, 5: 11235.


Researcher : Li YV
List of Research Outputs

Li Y.V., Lam S.K., Zheng C. and Ho J.C.M., The Effect of Tumor Microenvironment on Autophagy and Sensitivity to Targeted Therapy in EGFR-Mutated Lung Adenocarcinoma, Journal of Cancer. 2015, 6: 382-386.


Researcher : Lian Q
Project Title:The Roles and Mechanisms of human mesenchymal stem cell-mediated cardial protection against anthracycline-induced cardiomyopathy
Investigator(s):Lian Q
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2012


Project Title:The Roles and Mechanisms of RAP1/NFkb signaling pathway in MSC-induced immunomodulation for organ transplantation
Investigator(s):Lian Q, Poon MW, He J
Department:Medicine
Source(s) of Funding:National Natural Science Foundation of China (NSFC) - General Program
Start Date:01/2013


Project Title:Platform of Human Pluripotent Stem Cell-derived Mesenchymal Stem Cells for Tissue Regeneration and Industrial Application
Investigator(s):Lian Q, Tse HF, Poon MW
Department:Medicine
Source(s) of Funding:Innovation and Technology Support Programme (Tier 3)
Start Date:01/2013


Project Title:Platform of Human Pluripotent Stem Cell-derived Mesenchymal Stem Cells for Tissue Regeneration and Industrial Application
Investigator(s):Lian Q, Tse HF, Poon MW
Department:Medicine
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:04/2013


Project Title:Generation, Purification and Transplantation of human Pluripotent Stem Cell -derived Cone and Rod Photoreceptor Cells for Retinal Degenerative Disease
Investigator(s):Lian Q, Wong DSH
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2013


Project Title:International Society for Stem Cell Research 11th Annual Meeting; ACTIVATION OF NRG1/ERBB4 SIGNALING PATHYWAY IN MESENCHYMAL STEM CELLS ENHANCES CELL SURVIAL AND PARACRINE POTENTIALS AGAINST MYOCARDIAL INFARCTION
Investigator(s):Lian Q
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2013


Project Title:Platform of Human Pluripotent Stem Cell-derived Mesenchymal Stem Cells for Tissue Regeneration and Industrial Application
Investigator(s):Lian Q, Tse HF, Poon MW
Department:Medicine
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:07/2013


Project Title:Functional roles of human ESC/iPSC-derived mesenchymal stem cell-deposited matrixes for improving survive and functions of retinal pigment epithelial cell (RPE)
Investigator(s):Lian Q
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2014


Project Title:Direct Mitochondrial Transfer of Stem Cells Restores Ocular Mitochondrial Dysfunction: The Role of NF-κB Activation
Investigator(s):Lian Q, Wong DSH
Department:Ophthalmology
Source(s) of Funding:Small Project Funding
Start Date:04/2015


Project Title:2015 ISSCR Annula Meeting ; MITOCHONDRIAL TRANSFER OF IPSC-DERIVEDMESENCHYMAL STEM CELLS REJUVENATES DAMAGED CARDIOMYOCYTE AGAINSTANTHRACYCLINE-INDUCED CARDIOMYOPATHY
Investigator(s):Lian Q
Department:Ophthalmology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2015


List of Research Outputs

LI X., Michaeloudes C., Zhang Y., Lian Q., Mak J.C.W., Bhavsar P.K. and Chung K., Oxidative stress-induced mitochondria alteration in human airway smooth muscle cells and mesenchymal stem cells, Am J Respir Crit Care Med. 2015, 191: A5544.
LIANG Y., LI X., Zhang Y., ZHEN Z., Yeung S.C., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Amelioration of cigarette smoke-induced cardiac dysfunction and inflammation by mesenchymal stem cells, J HK Coll Cardiol. 2014, 22: 49.
Li X., Zhang Y., Yeung S.C., Liang Y., Li X., Ding Y., Ip M.S.M., Tse H.F., Mak J.C.W. and Lian Q., Mitochondrial transfer of induced pluripotent stem cells-derived MSCs to airway epithelial cells attenuates cigarette smoke-induced damage, American Journal of Respiratory Cell and Molecular Biology. 2014, 51(3): 455-465.
Lian Q., 71. 2015: Croucher Foundation Advanced Study Institute on Stem Cells: Biology and Application. Invited Speaker .Title: Mesenchymal stem cell differentiation from human ESC/iPSC: the way from bench to bedside. 2015, Jan 5-7; Hong Kong. Stem Cell Mitochondrial Transfer Restores Mitochondrial Dysfunction in Anthracyclines-induced Cardiomyopathy: From Animal Studies to Clinical Perspective. , 2014 Karolinska Institute - Hong Kong Regenerative Medicine Retreat . 2014,Oct 23-24. Hong Kong . 2014.
Lin Z., Pan X., Wu F., Ye D., Zhang Y., Wang Y., Jin L., Lian Q., Huang Y., Ding H., Triggle C., Wang K., Li X. and Xu A., Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice, Circulation. 2015, 131(21): 1861-1871.
Qi X., Ng K.T.P., Lian Q., Liu X., Li C., Ma Y.Y., Yeung W.H., Tu W., Fan S.T., Lo C.M. and Man K., Clinical significance and therapeutic value of glutathione peroxidase 3 (GPx3) in hepatocellular carcinoma, Oncotarget. 2014, Epub on 2014-10-11.
SONG Y., Pan G., Chen L., Ma S.K.Y., Zeng T., Chan T.H., Li L., Lian Q., CHOW K.K., Cai X., Li Y., Li Y., Liu M., LI Y., Zhu Y., Wong N., Yuan Y.F., Pei D. and Guan X., Loss of ATOH8 increases stem cell features of hepatocellular carcinoma cells, Gastroenterology. 2015.
WANG Y., WANG P., Xia Z., Lian Q., Zhang M.Q. and Wang J.J., EATdb: A Database of Human Enhancers and Their Putative Targets, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014.. 2014.
Wang P., Wang L.Y., Lian Q., Zhang M.Q., Xia Z. and Wang J.J., EATdb: a database of human enhancers and their putative targets, The 2015 American College of Medical Genetics and Genomics (ACMG) Annual Clinical Genetics Meeting, Salt Lake City, US, 24-28 March 2015.. 2015.


Researcher : Liang Q
List of Research Outputs

Liang Q., Zhong L., Zhang J., Wang Y., Bornstein S.R., Hong D., Triggle C. and Xu A., FGF21 Maintains Glucose Homeostasis by Mediating the Cross Talk Between Liver and Brain During Prolonged Fasting., Diabetes. 2014, Jul 14 Epub ahead of print.


Researcher : Liang RHS
List of Research Outputs

Hung I.F.N., Chan K.H., Liang R.H.S., Lai T.S.T. and Yuen K.Y., Harvesting Convalescent Plasma for Hyperimmune Intravenous Globulin Production: A Multicentre Randomized Double-Blind Controlled Trial for Treatment of Patients with Serious S-OIV H1N1 Infection, Health Research Symposium 2014, Hong Kong, 15 Nov 2014. (Poster presentation). 2014.
Ma E.S.K., Liang R.H.S., Chu K.M. and Lau G.K.K., Complete response of acquired FV inhibitor to rituximab, International Journal of Hematology. 2015, 101: 421-422.


Researcher : Liang Y
List of Research Outputs

CUI Y., LIANG Y., Ip M.S.M. and Mak J.C.W., Effects of epigallocatechin gallate on smoke-induced oxidative stress and apoptosis in rat lung in vivo, Respirology. 2015, 20 (Supplement 1): 11.
CUI Y., LIANG Y., Ip M.S.M. and Mak J.C.W., Travel Award - Effects of epigallocatechin gallate on cigarette smoke-induced oxidative stress and apoptosis in rat lung in vivo, Airway Vista 2015. 2015.
LIANG Y., LI X., Zhang Y., Lian Q. and Mak J.C.W., Amelioration of cigarette smoke-induced cardiac dysfunction and inflammation by mesenchymal stem cells., The 18th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, Hong Kong, 1 November 2014. In Journal of the Hong Kong College of Cardiology, 2014, v. 22 n. 2, p. 49, abstract no. OP2. 2014.
LIANG Y., LI X., Zhang Y., ZHEN Z., Yeung S.C., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Amelioration of cigarette smoke-induced cardiac dysfunction and inflammation by mesenchymal stem cells, J HK Coll Cardiol. 2014, 22: 49.
LIANG Y., Ip M.S.M. and Mak J.C.W., Epigallocatechin gallate alleviated cigarette smoke-induced cardiac inflammation, Respirology . 2015, 20 (Supplement 1): 11.
LIANG Y., LI X., Zhang Y., ZHEN Z., Yeung S.C., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Outstanding Oral presentation - Amelioration of cigarette smoke-induced cardiac dysfunction and inflammation by mesenchymal stem cells , 18th Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine. 2014.
Li X., Zhang Y., Yeung S.C., Liang Y., Li X., Ding Y., Ip M.S.M., Tse H.F., Mak J.C.W. and Lian Q., Mitochondrial transfer of induced pluripotent stem cells-derived MSCs to airway epithelial cells attenuates cigarette smoke-induced damage, American Journal of Respiratory Cell and Molecular Biology. 2014, 51(3): 455-465.
Zhang Y., LIANG X., Liao S., Wang W., Wang J.J., LI X., Ding Y., LIANG Y., GAO F., Yang M., Fu Q., Xu A., Chai Y.H., He J., Tse H.F. and Lian Q., Potent Paracrine Effects of human induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Attenuate Doxorubicin-induced Cardiomyopathy, Scientific Reports. 2015, 5: 11235.


Researcher : Liao S
Project Title:Efficacy and Safety of Human Embryonic Stem Cell-derived Cardiomyocytes in Post-Myocardial Infarction Heart Failure
Investigator(s):Liao S, Zhu Z
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:04/2015


List of Research Outputs

Liao S., Liu Y., Zhang Y., Au K.W., Lai K.W.H., Siu D.C.W. and Tse H.F., Remodelling of cardiac sympathetic re-innervation with thoracic spinal cord stimulation improves left ventricular function in a porcine model of heart failure., Europace. 2015, 2105 MAR 12: 409.
Zhang Y., LIANG X., Liao S., Wang W., Wang J.J., LI X., Ding Y., LIANG Y., GAO F., Yang M., Fu Q., Xu A., Chai Y.H., He J., Tse H.F. and Lian Q., Potent Paracrine Effects of human induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Attenuate Doxorubicin-induced Cardiomyopathy, Scientific Reports. 2015, 5: 11235.


Researcher : Lie AKW
List of Research Outputs

Cheung C.Y., Tam S., Lam C.W., Lie A.K.W. and Kwong Y.L., Allogeneic haematopoietic stem cell transplantation for erythropoietic protoporphyria: A cautionary note, Blood Cells, Molecules, and Diseases. 2015, 54: 266-267.
Chim J.C.S., Sim P.Y.J., Tam S., Tse E.W.C., Lie A.K.W. and Kwong Y.L., LDH is an adverse prognostic factor independent of ISS in transplant-eligible myeloma patients receiving bortezomib-based induction regimens, European Journal of Haematology. 2014, n/a-n/a.
Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Liu S.H.K., Singh G.H.H., Lam Y.F., Fung J.Y.Y., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., A prospective study of hepatitis B reactivation in patients with prior HBV exposure undergoing hematopoietic stem cell transplantation: Reactivation association with graft-versus-host disease, Oral presentation at the International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2015, 62(Suppl 2): S194.
Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Hepatitis B reactivation in patients with prior HBV exposure undergoing rituximab-containing chemotherapy for lymphoma: a prospective study, Journal of Clinical Oncology. 2014, 32(33): 3736-43.
Singh G.H.H., Hwang Y.Y.G., Chan T.S.Y., Chan C.C., Chan C.H.Y., Liu H.S.Y., Mak V., Lin S.Y., Lau C.K., Leung A.Y.H., Lie A.K.W. and Kwong Y.L., Clinicopathologic Features and Outcome of Chinese Patients with Myelofibrosis, 56th ASH Annual Meeting and Exposition, San Francisco, CA.. Blood, 2014, 124 (21).
Tse E.W.C., Chan S.Y.T., Koh L.P., Chng W.J., Kim W.S., Tang T., Lim S.T., Lie A.K.W. and Kwong Y.L., Allogeneic haematopoietic SCT for natural killer/T-cell lymphoma: a multicentre analysis from the Asia Lymphoma Study Group, Bone Marrow Transplantation. 2014, 49: 902-906.


Researcher : Liu SHK
List of Research Outputs

Hung I.F.N., Liu S.H.K., Tan V.P.Y., Hsu A.S.J., Seto W.K.W., Tong S.M. and Leung W.K., Seven-day Rifabutin Containing Triple Therapy Versus Seven-day Levofloxacin Containing Quadruple Therapy as Second-line Treatment for Helicobacter pylori in Chinese Patients: an Open Label, Randomized Trial, Digestive Disease Week 2015. (Oral presentation). 2015, S149.
Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Liu S.H.K., Singh G.H.H., Lam Y.F., Fung J.Y.Y., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., A prospective study of hepatitis B reactivation in patients with prior HBV exposure undergoing hematopoietic stem cell transplantation: Reactivation association with graft-versus-host disease, Oral presentation at the International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2015, 62(Suppl 2): S194.
Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Hepatitis B reactivation in patients with prior HBV exposure undergoing rituximab-containing chemotherapy for lymphoma: a prospective study, Journal of Clinical Oncology. 2014, 32(33): 3736-43.
Seto W.K.W., Tanaka Y., Wong D.K.H., Shinkai N., Cheung K.S., Liu S.H.K., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Longitudinal serologic profiles up to 5 years in hepatitis B surface antigen-negative chronic hepatitis B, Hepatology. 2014, 60, No. 4 (Suppl): 57A.
Tan V.P.Y., Liu S.H.K., Lam Y.F., Hung I.F.N., Yuen R.M.F. and Leung W.K., Rifaximin for the Treatment of Functional Dyspepsia: A Double-Blind Randomized Placebo-Controlled Trial., Digestive Diseases Week 2015.


Researcher : Liu Y
List of Research Outputs

Liao S., Liu Y., Zhang Y., Au K.W., Lai K.W.H., Siu D.C.W. and Tse H.F., Remodelling of cardiac sympathetic re-innervation with thoracic spinal cord stimulation improves left ventricular function in a porcine model of heart failure., Europace. 2015, 2105 MAR 12: 409.


Researcher : Lo WK
List of Research Outputs

Chen J.Y., Tsang J.P.Y., Lui S.L., Lo W.K., Tang S.C.W., Chan D.T.M. and Lam C.L.K., The illness experience of end stage renal disease patients in Hong Kong undergoing hemodialysis, Communication, Ethics and Medicine (COMET) conference. 2015.
Shea Y.F., Lam M.F., Lee M.S., Mok T.M.Y., Lui S.L., Yip T.P.S., Lo W.K., Chu L.W. and Chan D.T.M., Prevalence of CMMSE defined cognitive impairment among peritoneal dialysis patients and its impact on peritonitis, Clinical And Experimental Nephrology. 2015, 21 May 2015: Epub ahead of print.
Yung S.S.Y., Lui S.L., Ng K.F., Yim A.S.Y., Ma K.M.M., Lo W.K., Chow C.C., Chu K.H., Chak W.L., Lam M.F., Yung C.Y., Yip T.P.S., Wong S., Tang S.O.C., Ng F.S.K. and Chan D.T.M., Impact of a Low-Glucose Peritoneal Dialysis Regimen on Fibrosis and Inflammation Biomarkers, Peritoneal Dialysis International. 2015, 35: 147-158.


Researcher : Lo Y
List of Research Outputs

GAO Y., Lo Y., Wan H.Y., Lau Y.Y., Lau C.S. and Mok T.M.Y., Cognitive function in systemic lupus erythematosus patients with past history of neuropsychiatric manifestations: A longitudinal study, Hong Kong Medical Journal 2015;21:p20 (Abstract 22) . 2015.
GAO Y., Lo Y., Lau C.S. and Mok T.M.Y., Cognitive symptoms and associated disease and non-disease related factors in patients with systemic lupus erythematosus: A longitudinal study, Arthritis Rheum 2014;66;S1162 (Abstract 2658) . 2014.
GAO Y., Lo Y. and Mok T.M.Y., Symptoms of attention deficit hyperactivity disorder in patients with systemic lupus erythematosus. European League of Association of Rheumatology (EULAR) 2015 Ann Rheum Dis 2015;74(Suppl2), 2015, 74(Suppl2): 575.
GAO Y., Lo Y. and Mok T.M.Y., Symptoms of attention deficit hyperactivity disorder in patients with systemic lupus erythematosus, Lupus. 2015.
GAO Y., Lo Y. and Mok T.M.Y., Systemic lupus erythematosus patients with past neuropsychiatric involvement is associated with worse cognitive impairment : a longitudinal study. European League of Association of Rheumatology (EULAR) 2015 Ann Rheum Dis 2015;74(Suppl2), 2015, 74(Suppl2): 1099.
WU H., Lo Y., LUK T.W., Lau C.S., Lu L.W. and Mok T.M.Y., Alternatively activated dendritic cells derived from systemic lupus erythematosus patients have tolerogenic phenotype and function.European League of Association of Rheumatology (EULAR) 2015 Annals of the Rheumatic Diseases 2015; 74(Suppl2), 2015, 74(Suppl2): 951.
WU H., Lo Y., Luk D., Lau W.C.S., Lu L. and Mok T.M.Y., Alternatively activated dendritic cells derived from systemic lupus erythematosus patients have tolerogenic phenotype and function, Clinical Immunology. 2015, 156: 43-57.
WU H., Lo Y., LUK T.W., Lau C.S., Lu L. and Mok T.M.Y., Alternatively activated dendritic cells derived from systemic lupus erythematosus patients have tolerogenic phenotype and function, Hong Kong Medical Journal 2015;21:p55 (Abstract 90) . 2015.
WU H., Lo Y., LUK T.W., Chan W.K. and Mok T.M.Y., Bone marrow derived dendritic cells modified by lentiviral-mediated RelB shRNA possess tolerogenic phenotype and functions on lupus splenic lymphocytes. European League of Association of Rheumatology (EULAR) 2015. Ann Rheum Dis 2015; 74(Suppl2), 2015, 74(Suppl2): 951.


Researcher : Lui MSM
List of Research Outputs

Lam C.L.D., Tam C.C.T., Lau K.M., Wong W.M., Hui K.M.C., Lam J.C., Wang J.K., Lui M.S.M., Ho J.C.M. and Ip M.S.M., Plasma EGFR Mutation Detection Associated With Survival Outcomes in Advanced-Stage Lung Cancer, Clinical Lung Cancer [Epub ahead of print]. 2015.


Researcher : Lui SL
List of Research Outputs

Chen J.Y., Tsang J.P.Y., Lui S.L., Lo W.K., Tang S.C.W., Chan D.T.M. and Lam C.L.K., The illness experience of end stage renal disease patients in Hong Kong undergoing hemodialysis, Communication, Ethics and Medicine (COMET) conference. 2015.
Shea Y.F., Lam M.F., Lee M.S., Mok T.M.Y., Lui S.L., Yip T.P.S., Lo W.K., Chu L.W. and Chan D.T.M., Prevalence of CMMSE defined cognitive impairment among peritoneal dialysis patients and its impact on peritonitis, Clinical And Experimental Nephrology. 2015, 21 May 2015: Epub ahead of print.
Yung S.S.Y., Lui S.L., Ng K.F., Yim A.S.Y., Ma K.M.M., Lo W.K., Chow C.C., Chu K.H., Chak W.L., Lam M.F., Yung C.Y., Yip T.P.S., Wong S., Tang S.O.C., Ng F.S.K. and Chan D.T.M., Impact of a Low-Glucose Peritoneal Dialysis Regimen on Fibrosis and Inflammation Biomarkers, Peritoneal Dialysis International. 2015, 35: 147-158.


Researcher : Luk JKH
List of Research Outputs

Chan T.C.I., Hung I.F.N., Chan K.H., Li P.Y., Li T.W., Luk J.K.H., Chu L.W. and Chan H.W.F., A Randomized Controlled Trial to Compare Immunogenicity Between Intramuscular and Intradermal Trivalent Influenza Vaccination in Nursing Home Older Adults, 20th Medical Research Conference, The University of Hong Kong, 17 Jan 2015.. 2015.
Chan T.C.I., Hung I.F.N., Luk J.K.H., Chu L.W. and Chan H.W.F., Comparing Effectiveness Between Intramuscular and Intradermal Trivalent Influenza Vaccination in Nursing Home Residents: A Randomized Controlled Trial, 20th Medical Research Conference, The University of Hong Kong, 17 Jan 2015. (Oral presentation). 2015.
Chan T.C.I., Hung I.F.N., Chan K.H., Li P.Y., Li T.W., Luk J.K.H., Chu L.W. and Chan H.W.F., Local Adverse Effect of Intradermal and Administration of Influenza Vaccination is an Indicator of Satisfactory Immunogenicity, 20th Medical Research Conference 2015, The University of Hong Kong, 17 Jan 2015. . 2015.
Chan T.C.I., Hung I.F.N., Luk J.K.H., Chu L.W. and Chan H.W.F., Prevalence of Influenza Vaccination and Associated Factors Among Chinese Nursing Home Health Care Workers, 20th Medical Research Conference 2015, The University of Hong Kong, 17 Jan 2015.. 2015.
Chan W.C., Yeung W.F., WONG S.M., Lam L.C.W., Chung K.F., Luk J.K.H., Lee J.S.W. and Law A.C.K., Efficacy of Physical Exercise in Preventing Falls in Older Adults With Cognitive Impairment: A Systematic Review and Meta-Analysis, Journal of the American Medical Directors Association. 2015, 16: 149-154.


Researcher : MA X
List of Research Outputs

Chan D.T.M., Au K.Y., MA X., Tse W.W., Chau K.M. and Yung S.S.Y., CD44 expression in serum and kidney correlates with disease activity in lupus nephritis, 52nd European Renal Association/European Dialysis Transplantation Association Congress. 2015.
Chan D.T.M., Au K.Y., MA X., Tse W.W., Chau K.M. and Yung S.S.Y., Serum and renal expression of CD44s and its variants correlate with disease activity in lupus nephritis, World Congress of Nephrology 2015.


Researcher : Ma CH
Project Title:The role of inka1b in zebrafish hematopoiesis
Investigator(s):Ma CH, Leung AYH
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2014


Project Title:7th Zebrafish Disease Models Conference; A novel role of Inka1 in regulating zebrafish hematopoiesis
Investigator(s):Ma CH
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2014
Completion Date:07/2014


Project Title:The role of calreticulin in normal hematopoiesis and myeloproliferative neoplasms
Investigator(s):Ma CH
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2015


Project Title:Developing an in vivo zebrafish platform for functional evaluation of recurrent mutations in acute myeloid leukemia (AML) and primary screening of novel targeted therapeutic agents
Investigator(s):Ma CH, Leung AYH
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:05/2015


List of Research Outputs

HU J., WONG N.K., YE S., Chen X., LU M., ZHAO Q., GUO Y., Ma C.H., Leung A.Y.H., Shen J. and Yang D., Fluorescent Probe HKSOX-1 for Imaging and Detection of Endogenous Superoxide in Live Cells and In VivoJournal of the American Chemical Society, Journal of the American Chemical Society. 2015, 137: 6837-6843.
LEUNG K.C., Ma C.H., Gao W., Chu W.Y., Wong W.L., Jin D., Lo I.F.M., Luk H.M. and Chung B.H.Y., Contribution of gain-of-function mutations in R1T1 to the pathogenesis of Noonan syndrome - A report of 3 new Chinese patients in Hong Kong (1st runner-up prize of best oral presentation), 50th Anniversary Scientific Meeting, Dept of Paed & Adol Med, HKU, 29-30 November 2014.
SHI X., HE B., Ma C.H., GUO Y., Chi Y., Zhang W., Zhang Y., Wen Z., Cheng T. and Leung A.Y.H., Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish, Blood. 2015, 125: 2974-2984.


Researcher : Ma KMM
List of Research Outputs

Yap Y.H.D., Ma K.M.M., Mok M.M., Kwan L.P., Chan G.C. and Chan D.T.M., Long-term data on tacrolimus treatment in lupus nephritis, Rheumatology. Oxford, 2014, 53(12): 2232-2237 [Epub 4 Jul 2014].
Yung S.S.Y., Lui S.L., Ng K.F., Yim A.S.Y., Ma K.M.M., Lo W.K., Chow C.C., Chu K.H., Chak W.L., Lam M.F., Yung C.Y., Yip T.P.S., Wong S., Tang S.O.C., Ng F.S.K. and Chan D.T.M., Impact of a Low-Glucose Peritoneal Dialysis Regimen on Fibrosis and Inflammation Biomarkers, Peritoneal Dialysis International. 2015, 35: 147-158.


Researcher : Mak JCW
Project Title:Role of transforming growth factor-beta1 variants in susceptibility to tuberculosis in Hong Kong Chinese population
Investigator(s):Mak JCW, Chan MMW
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2005


Project Title:Investigating the mechanisms of cigarette smoke-induced disruption of serotonin homeostasis in the airways in vitro and in vivo - relevant to chronic obstructive pulmonary disease
Investigator(s):Mak JCW
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2012


Project Title:The role of visfatin in cigarette smoke-induced inflammatory responses in human airway epithelial cells and macrophages
Investigator(s):Mak JCW
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2013


Project Title:Therapeutic Potential of Human Induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells (hiPSC-MSCs) on oxidative stress-induced
Investigator(s):Mak JCW
Department:Medicine
Source(s) of Funding:National Natural Science Foundation of China (NSFC) - General Program
Start Date:01/2014


Project Title:Biological roles of estrogen in the modulation of cigarette smoke-induced inflammation in human airway epithelial cells
Investigator(s):Mak JCW
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2014


Project Title:The effect of cigarette smoke on the regulation of lipocalin 2 in airway cells in vitro and in vivo – relevant to chronic obstructive pulmonary disease
Investigator(s):Mak JCW
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2015


List of Research Outputs

CHEN S., Mak J.C.W., Tong H.H.Y. and Kwok P.C.L., Inhalable Oleanolic Acid-Hypromellose Particles for Controlled Release, 40th Micro and Nano Engineering 2014, Lausanne, Switzerland, September 22-26, 2014.
CUI Y., LIANG Y., Ip M.S.M. and Mak J.C.W., Effects of epigallocatechin gallate on smoke-induced oxidative stress and apoptosis in rat lung in vivo, Respirology. 2015, 20 (Supplement 1): 11.
CUI Y., Ip M.S.M. and Mak J.C.W., The role of serotonin homeostasis in airway oxidative stress and inflammation in airway epithelial cells, Am J Respir Crit Care Med. 2015, 191: A1276.
CUI Y., LIANG Y., Ip M.S.M. and Mak J.C.W., Travel Award - Effects of epigallocatechin gallate on cigarette smoke-induced oxidative stress and apoptosis in rat lung in vivo, Airway Vista 2015. 2015.
Hui W.S., Ho S.P., Wong A.T., Ho P.L. and Mak J.C.W., Cellular signaling pathways of matrix metalloproteinase gene expression by Pseudomonas aeruginosa-infected human bronchial epithelial cells, Hong Kong Med J. 2014, 20: 14-17.
LI X., Michaeloudes C., Zhang Y., Lian Q., Mak J.C.W., Bhavsar P.K. and Chung K., Oxidative stress-induced mitochondria alteration in human airway smooth muscle cells and mesenchymal stem cells, Am J Respir Crit Care Med. 2015, 191: A5544.
LIANG Y., LI X., Zhang Y., Lian Q. and Mak J.C.W., Amelioration of cigarette smoke-induced cardiac dysfunction and inflammation by mesenchymal stem cells., The 18th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, Hong Kong, 1 November 2014. In Journal of the Hong Kong College of Cardiology, 2014, v. 22 n. 2, p. 49, abstract no. OP2. 2014.
LIANG Y., LI X., Zhang Y., ZHEN Z., Yeung S.C., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Amelioration of cigarette smoke-induced cardiac dysfunction and inflammation by mesenchymal stem cells, J HK Coll Cardiol. 2014, 22: 49.
LIANG Y., Ip M.S.M. and Mak J.C.W., Epigallocatechin gallate alleviated cigarette smoke-induced cardiac inflammation, Respirology . 2015, 20 (Supplement 1): 11.
LIANG Y., LI X., Zhang Y., ZHEN Z., Yeung S.C., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Outstanding Oral presentation - Amelioration of cigarette smoke-induced cardiac dysfunction and inflammation by mesenchymal stem cells , 18th Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine. 2014.
Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Intermittent hypoxia-induced adipocyte derived secretory products cause inflammatory responses in endothelial cells in vitro, Eur Respir J. 2014, 44: Suppl. 58, 4447.
Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Intermittent hypoxia-induced adipocyte derived secretory products cause inflammatory responses in endothelial cells in vitro, European Respiratory Society International Congress 2014, Munich, Germany, Sep 2014. Abst. 4447.
Leung S.W.S., Cao L., ZHANG P., Man R.Y.K. and Mak J.C.W., Effects of isoflavones on the release of inflammatory mediators by cigarette smoke in airway epithelial cells , ASCEPT-BPS Joint Scientific Meeting "Tomorrow's medicines: pharmacology, patients and populations" 2015, 19-21 May 2015, Hong Kong . 2015.
Li X., Zhang Y., Yeung S.C., Liang Y., Li X., Ding Y., Ip M.S.M., Tse H.F., Mak J.C.W. and Lian Q., Mitochondrial transfer of induced pluripotent stem cells-derived MSCs to airway epithelial cells attenuates cigarette smoke-induced damage, American Journal of Respiratory Cell and Molecular Biology. 2014, 51(3): 455-465.
Mak J.C.W., Editorial Board Member, Scientific Reports - Open Access. Nature Publishing Group, 2014.
Mak J.C.W., Mitochondrial transfer by stem cells, Sadoul Lecture "From molecules and cells to phenotypes: deciphering chronic airways disease at the ERS Munich 2014 Congress. 2014.
WANG Y., Yeung S.C., Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Intermittent hypoxia accelerates adipogenic differentiation in human subcutaneous preadipocytes in vitro, Am J Respir Crit Care Med. 2015, 191: A2704.


Researcher : Mak W
List of Research Outputs

Lau G.K.K., Chan L.K., Li O.Y., Yuen T.K., Wong Y.K., Chan K.H., Chan J.F.W., Chang S.K.R., Cheung R.T.F., Doherty I., Ho S.L., Hon F.K.S., Kwan S.K.J., Lee R., Leung G.K.K., Mak W., Mak H.K.F., Shih K.C. and Tsang C.O.A., Establishing an eLearning Platform in Clinical Neurosciences, East-West Alliance Global Symposia 2014.
Lau G.K.K., Chiu K.C.P., Shih K.C., Chu L.W., Ho S.L. and Mak W., Miller Fisher syndrome in a Chinese octogenarian presenting with dizziness, Asian Journal of Gerontology & Geriatrics. Hong Kong Academy of Medicine Press, 2014, 9:2: 93–5.
Lee J.C., Pang S.Y., Lam C.L.D., Tse A.C., Lau G.K.K., Chang S.K.R., Ho S.L., Cheung R.T.F., Mak W., Hon F.K.S., Chang C.K., Teo K.L. and Chan K.H., Myasthenic crisis in patients with generalised myasthenia gravis. Hong Kong Academy of Medicine, 2014., 2015.


Researcher : Man CH
List of Research Outputs

Singh G.H.H., Man C.H., Ip H.W., Choi W.L., Chow H.C.H., Kwong Y.L. and Leung A.Y.H., Azacitidine as post-remission consolidation for sorafenib-induced remission of Fms-Like Tyrosine Kinase-3 internal tandem duplication positive acute myeloid leukemia, Haematologica. 2015.


Researcher : Mok TMY
Project Title:The generation of a mouse model to study the role of IL-33 in systemic lupus erythematosus
Investigator(s):Mok TMY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2013
Completion Date:06/2015


Project Title:The role of IL-33 in the modulation of macrophage differentiation and immunoregulatory functions in systemic lupus erythematosus
Investigator(s):Mok TMY, Lau WCS, Chan GCF, Chan KW
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2014


Project Title:Subgingival microbiota in patients with early and established rheumatoid arthritis
Investigator(s):Mok TMY, Leung WK
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2014


Project Title:Effect of RelB silenced dendritic cells on induction of immune tolerogenicity: perspectives from systemic lupus erythematosus
Investigator(s):Mok TMY
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:03/2015


List of Research Outputs

Au Y.L.E., Wong R.W.S., Mok T.M.Y., Chung H.Y., Chan Y.T.E. and Lau W.C.S., Disease activity assessment in ankylosing spondylitis in a Chinese cohort: BASDAI or ASDAS?, Clinical Rheumatology . 2014, 33: 1127-1134.
GAO Y. and Mok T.M.Y., Cognitive dysfunction and disease and non-disease associated factors in systemic lupus erythematosus: Longitudinal perspectives , PhD thesis. 2015.
GAO Y., Wan H.Y., Lau E.Y., Lau C.S. and Mok T.M.Y., Cognitive function in systemic lupus erythematosus patients with past history of neuropsychiatric manifestations: A longitudinal study, Arthritis Rheum 2014;66:S1162 (Abstract 2654) . 2014.
GAO Y., Lo Y., Wan H.Y., Lau Y.Y., Lau C.S. and Mok T.M.Y., Cognitive function in systemic lupus erythematosus patients with past history of neuropsychiatric manifestations: A longitudinal study, Hong Kong Medical Journal 2015;21:p20 (Abstract 22) . 2015.
GAO Y., Lo Y., Lau C.S. and Mok T.M.Y., Cognitive symptoms and associated disease and non-disease related factors in patients with systemic lupus erythematosus: A longitudinal study, Arthritis Rheum 2014;66;S1162 (Abstract 2658) . 2014.
GAO Y., Cheung R.T.F., Gao J., Lau E.Y.Y., WAN H.Y. and Mok T.M.Y., Evaluation of cognitive function by electrophysiological study in systemic lupus erythematosus patients with previous neuropsychiatric involvement. European League of Association of Rheumatology (EULAR) 2015, Ann Rheum Dis 2015; 74(Suppl2), 2015, 74(Suppl2): 1099.
GAO Y., Lo Y. and Mok T.M.Y., Symptoms of attention deficit hyperactivity disorder in patients with systemic lupus erythematosus. European League of Association of Rheumatology (EULAR) 2015 Ann Rheum Dis 2015;74(Suppl2), 2015, 74(Suppl2): 575.
GAO Y., Lo Y. and Mok T.M.Y., Symptoms of attention deficit hyperactivity disorder in patients with systemic lupus erythematosus, Lupus. 2015.
GAO Y., Lo Y. and Mok T.M.Y., Systemic lupus erythematosus patients with past neuropsychiatric involvement is associated with worse cognitive impairment : a longitudinal study. European League of Association of Rheumatology (EULAR) 2015 Ann Rheum Dis 2015;74(Suppl2), 2015, 74(Suppl2): 1099.
Mok T.M.Y., Management of Rheumatoid Arthritis – Focus on Measurement in the Context of Early Diagnosis and Treating to Target. , Research Review (Expert commentary). 2014.
Mok T.M.Y., Neuropsychiatric lupus, Bitgoeul Chonnam National University Hospital, Gwangju, Korea . 2014.
Mok T.M.Y., News and Views from APLAR region (July 2014), International Journal of Rheumatic Diseases. 2014.
Mok T.M.Y., News and Views from APLAR region (Nov 2014), International Journal of Rheumatic Diseases . 2014.
Mok T.M.Y., News and Views from APLAR region (Sept 2014), International Journal of Rheumatic Diseases. 2014.
Mok T.M.Y., News and Views from the APLAR region (Jan 2015), International Journal of Rheumatic Diseases. 2015.
Mok T.M.Y., News and Views from the APLAR region. International Journal of Rheumatic Diseases 2015, Mar 2015, 2015.
Mok T.M.Y., News and Views from the APLAR region. International Journal of Rheumatic Diseases 2015; May 2015, 2015.
Mok T.M.Y., Rheumatoid arthritis: how to make an early diagnosis and update on management? , The Society of Physicians of Hong Kong. 2014.
Mok T.M.Y., Rheumatology training and practice in Hong Kong. , Arise with APLAR, Asia Pacific Rheumatology Intensive Scientific Educational Series, Beijing, China. 2014.
Mok T.M.Y., Special issue on Asian Lupus (Guest Editor), International Journal of Rheumatic Diseases. 2015.
Mok T.M.Y., Tolerogenic dendritic cells: Role and therapeutic implications in systemic lupus erythematosus, International Journal of Rheumatic Diseases (in press). 2014.
Mok T.M.Y., Where is air pollution heading in Hong Kong? Newsletter of the Hong Kong Institute of Allergy 2015, April, p7, 2015.
Shea Y.F., Lam M.F., Lee M.S., Mok T.M.Y., Lui S.L., Yip T.P.S., Lo W.K., Chu L.W. and Chan D.T.M., Prevalence of CMMSE defined cognitive impairment among peritoneal dialysis patients and its impact on peritonitis, Clinical And Experimental Nephrology. 2015, 21 May 2015: Epub ahead of print.
WU H., Lo Y., LUK T.W., Lau C.S., Lu L.W. and Mok T.M.Y., Alternatively activated dendritic cells derived from systemic lupus erythematosus patients have tolerogenic phenotype and function.European League of Association of Rheumatology (EULAR) 2015 Annals of the Rheumatic Diseases 2015; 74(Suppl2), 2015, 74(Suppl2): 951.
WU H., Lo Y., Luk D., Lau W.C.S., Lu L. and Mok T.M.Y., Alternatively activated dendritic cells derived from systemic lupus erythematosus patients have tolerogenic phenotype and function, Clinical Immunology. 2015, 156: 43-57.
WU H., Lo Y., LUK T.W., Lau C.S., Lu L. and Mok T.M.Y., Alternatively activated dendritic cells derived from systemic lupus erythematosus patients have tolerogenic phenotype and function, Hong Kong Medical Journal 2015;21:p55 (Abstract 90) . 2015.
WU H., Lo Y., LUK T.W., Chan W.K. and Mok T.M.Y., Bone marrow derived dendritic cells modified by lentiviral-mediated RelB shRNA possess tolerogenic phenotype and functions on lupus splenic lymphocytes. European League of Association of Rheumatology (EULAR) 2015. Ann Rheum Dis 2015; 74(Suppl2), 2015, 74(Suppl2): 951.
WU H. and Mok T.M.Y., The generation and therapeutic application of tolerogenic dendritic cells in systemic lupus erythematosus, PhD thesis. 2014.
ZHANG Y., Yang J., ZHANG J., Sun L., Hirankarn N., Pan H.F., Lau W.C.S., Chan T.M., Lee T.L., Leung A.M., Mok C.C., ZHANG L., WANG Y., Shen J.J., Wong S.N., Lee K.W., Ho M.H.K., Lee P.P.W., Chung B.H.Y., Chong C.Y., Wong R.W.S., Mok T.M.Y., Wong W.H.S., Tong K.L., Tse N.K.C., LI X.P., Avihingsanon Y., Rianthavorn P., SDeekajorndej T., Shotelersuk V., Suphapeetiporn K., Shotelersuk V., Ying S.K.Y., Fung S.K.S., Lai W.M., Wong C.M., Ng I.O.L., Sham P.C., Garcia-Barcelo M.M., Cherny S.S., Cui Y., Sham P.C., Yang S., Ye D.Q., Zhang X.J., Lau Y.L. and Yang W., Genome-wide search followed by replication reveals genetic interaction of CD80 and ALOX5AP associated with systemic lupus erythematosus in Asian populations, Annuals of Rheumatic Diseases. 2015.
Zhang Y., ZHANG J., Yang J., WANG Y., ZHANG L., Zuo X., Sun L., Pan H.F., Hirankarn N., WANG T., CHEN R., Ying D., Shen J.J., Lee T.L., Lau W.C.S., Chan D.T.M., Leung A.M.H., Mok C.C., Wong S.N., Lee K.W., Ho M.H.K., Lee P.P.W., Chung B.H.Y., Chong C.Y., Wong R.W.S., Mok T.M.Y., Wong W.H.S., Tong K.L., Tse N.K.C., Li X.P., Avihingsanon Y., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Shotelersuk V., Ying S.K.Y., Fung S.K.S., Lai W.M., Wong C.M., Ng I.O.L., Garcia-Barcelo M.M., Cherny S.S., Tam P.K.H., Sham P.C., Yang S., Ye D.Q., Cui Y., Zhang X.J., Lau Y.L. and Yang W., Meta-analysis of GWAS on two Chinese populations followed by replication identifies novel genetic variants on the X chromosome associated with systemic lupus erythematosus, Human Molecular Genetics. 2015, 24(1): 274-284.
Zhang Y., Wang Y., Yang J., ZHANG J., Sun L., Hirankarn N., Pan C.F., Lau W.C.S., Chan T.M., Lee T.L., Leung A.M.H., Mok C.C., ZHANG L., SHEN J., Wong S.N., Lee K.W., Ho M.H.K., Lee P.P.W., Chung B.H.Y., Chong C.Y., Wong R.W.S., Mok T.M.Y., Wong W.H.S., Tong K.L., Tse N.K., Li X.P., Avihingsanon Y., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Shotelersuk V., Ying S.K., Fung S.K., Lai W.M., Wong C.M., Ng I.O.L., Garcia-Barcelo M.M., Cherny S.S., Tam P.K.H., Sham P.C., Yang S., Ye D.Q., Cui Y., Zhang X.J., Yang W. and Lau Y.L., Meta-analysis of two Chinese populations identifies an autoimmune disease risk allele in 22q11.21 as associated with systemic lupus erythematosus, Arthritis Research & Therapy. 2015, 17: 67.


Researcher : Mok WCL
List of Research Outputs

ZHANG J., Zhang L., ZHANG Y., Yang J., Guo M., Sun L., Pan H.F., Hirankarn N., Ying D., ZENG S., Lee T.L., Lau W.C.S., Chan T.M., Leung A.M.H., Mok C.C., Wong S.N., Lee K.W., Ho M.H.K., Lee P.P.W., Chung B.H.Y., Chong C.Y., Wong R.W.S., Mok W.C.L., Wong W.H.S., Tong K.L., Tse N.K.C., LI X.P., Avihingsanon Y., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Shotelersuk V., Ying S.K.S., Fung S.K.S., Lai W.M., Garcia-Barcelo M.M., Cherny S.S., Sham P.C., Yong C., Yang S., Ye D.Q., Zhang X.J., Lau Y.L. and Yang W., Gene-based meta-analysis of GWAS data identifies independent SNPs in ANXA6 as associated with SLE in Asian populations, Arthritis & Rheumatology. 2014.


Researcher : Ng CL
Project Title:Adiponectin deficiency elicits neuroinflammation by overwhelmed microglia activation causing Alzheimer's disease and synaptic loss in aged mice
Investigator(s):Ng CL, Chan KH
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:03/2015


List of Research Outputs

Ng C.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Lam K.S.L., Xu A. and Chan K.H., Adiponectin deficiency induced cognitive dysfunction and Alzheimer’s disease pathogenesis in mice through the disruption of insulin sensitivity and inactivated AMPK signaling , 67th American Academy of Neurology Annual Meeting. 2015.
Ng C.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Lam K.S.L., Xu A. and Chan K.H., Research Travel Scholarship 2015, American Academy of Neruology. 2015.


Researcher : Ng FSK
List of Research Outputs

Yung S.S.Y., Lui S.L., Ng K.F., Yim A.S.Y., Ma K.M.M., Lo W.K., Chow C.C., Chu K.H., Chak W.L., Lam M.F., Yung C.Y., Yip T.P.S., Wong S., Tang S.O.C., Ng F.S.K. and Chan D.T.M., Impact of a Low-Glucose Peritoneal Dialysis Regimen on Fibrosis and Inflammation Biomarkers, Peritoneal Dialysis International. 2015, 35: 147-158.


Researcher : Ng KF
List of Research Outputs

Yung S.S.Y., Lui S.L., Ng K.F., Yim A.S.Y., Ma K.M.M., Lo W.K., Chow C.C., Chu K.H., Chak W.L., Lam M.F., Yung C.Y., Yip T.P.S., Wong S., Tang S.O.C., Ng F.S.K. and Chan D.T.M., Impact of a Low-Glucose Peritoneal Dialysis Regimen on Fibrosis and Inflammation Biomarkers, Peritoneal Dialysis International. 2015, 35: 147-158.


Researcher : Ng KM
Project Title:Novel Therapeutic Approach for X-linked related Danon Disease  Insight from Patient-specific Pluripotent Stem Cells Platform.
Investigator(s):Ng KM, Siu DCW, Tse HF
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2014


Project Title:Pathological contribution of lysosomal instability in LAMP2-deficiency induced neural dysfunction
Investigator(s):Ng KM, Tse HF
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2015


List of Research Outputs

Lee Y.K., Ng K.M. and Tse H.F., Modeling of Human Cardiomyopathy with Induced Pluripotent Stem Cells, Journal of Biomedical Nanotechnology. 2014, 10: 2562-2585.
NG A.K.Y., Ng K.M., Tse H.F., Lai K.W.H., CHAN W.S., Siu D.C.W. and Fan K., Pseudo-Pre-Excitation Unraveled Down to Its Core, Circulation. 2014, 130: e56-e58.
Ng K.M., LAW C.Y. and Tse H.F., Clinical Potentials of Cardiomyocytes Derived from Patient-Specific Induced Pluripotent Stem Cells, In: Prof. Jane Grant-Kels, Journal of Clinical Medicine. MDPI AG, Basel, Switzerland, 2014, 3: 1105-1123.


Researcher : Ngai WS
List of Research Outputs

Lai C.L., Wong D.K.H., Ip P.C.P., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lee B.P., Cullaro G., Wu C.H., Cheng C.T.K., Yuen J.C.H., Ngai W.S. and Yuen R.M.F., Profound Reduction of HBV Covalently Closed Circular DNA with Long-term Nucleoside/tide Analogue Therapy, Hepatology. 2014, 60, No. 4 (Suppl): 183A.
Wong D.K.H., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Hung I.F.N., Young J.L.P., Yuen J.C.H., Ngai W.S., Yuen R.M.F. and Lai C.L., Reduction of hepatitis B core related antigen by long term nucleoside nucleotide analogue therapy and its correlation with intrahepatic HBV DNA reduction, 24th Annual Conference of APASL, March 12–15, 2015, Istanbul, Turkey. Hepatology International. 2015, 9 (Suppl 1): S202.


Researcher : ONG KL
List of Research Outputs

Cheung Y.Y., Hui Y.L.E., Cheung B.M.Y., Woo Y.C., Xu A., Fong H.Y., Ong K.L., Yeung C.Y., Janus E.D., Tse H.F., Sham P.C. and Lam K.S.L., Adiponectin gene variants and the risk of coronary heart disease: a 16-year longitudinal study., Eur J Endocrinol. 2014, 171: 107-115.
ONG K.L., McClelland R.L., Rye K.A., Cheung B.M.Y., Post W.S., Vaidya D., Criqui M.H. and Cushman M., The relationship between insulin resistance and vascular calcification in coronary arteries, and the thoracic and abdominal aorta: The Multi-Ethnic Study of Atherosclerosis., Atherosclerosis. 2014, 236(2): 257-262.


Researcher : Ong KL
List of Research Outputs

Cheung Y.Y., Hui Y.L.E., Cheung B.M.Y., Woo Y.C., Xu A., Fong H.Y., Ong K.L., Yeung C.Y., Janus E.D., Tse H.F., Sham P.C. and Lam K.S.L., Adiponectin gene variants and the risk of coronary heart disease: a 16-year longitudinal study., Eur J Endocrinol. 2014, 171: 107-115.
ONG K.L., McClelland R.L., Rye K.A., Cheung B.M.Y., Post W.S., Vaidya D., Criqui M.H. and Cushman M., The relationship between insulin resistance and vascular calcification in coronary arteries, and the thoracic and abdominal aorta: The Multi-Ethnic Study of Atherosclerosis., Atherosclerosis. 2014, 236(2): 257-262.


Researcher : PAN Y
List of Research Outputs

Zhou M., PAN Y., SHU L., Lam K.S.L., Xu A. and Hoo R.L.C., A-FABP is a potential mediator of diabetic cardiomyopathy and ischemic reperfusion induced cardiac injury , 17th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM) . 2014.


Researcher : Pan K
List of Research Outputs

Pan K., LEE T.H.J., HUANG Z. and Wong C.M., Coupling and Coordination in Gene Expression Processes with Pre-mRNA Splicing, International Journal of Molecular Sciences. 2015, 16(3): 5682-5696.
Tang H.M., Pan K., Kong K.Y.E., Hu L., Chan L.C., Siu K.L., Sun H., Wong C.M. and Jin D., Loss of APD1 in Yeast Confers Hydroxyurea Sensitivity Suppressed by Yap1p Transcription Factor, Scientific Reports. 2015, 5: 7897.
Wong C.M., Pan K., HUANG Z. and LEE T.H.J., Current perspectives on the role of TRAMP in nuclear RNA surveillance and quality control, Research and Reports in Biochemistry. 2015, 5: 111-117.


Researcher : Pang AWK
List of Research Outputs

Singh G.H.H., Ip H.W., Pang A.W.K., Sum C.Y., Leung A.Y.H. and Kwong Y.L., FLT3 internal tandem duplication in acute promyelocytic leukemia: central nervous system relapse, Annals of Hematology. 2014.
So J.C.C., Chan K.H., Pang A.W.K., Chan J.K.F. and Kwong Y.L., Diganosis of brainstem involvement in NK/T cell lymphoma, Annals of Hematology. 2014, 93: 1433.


Researcher : Pang R.W.C.
Project Title:Study of a novel role of Pin1 in regulating invasiveness and metastasis of hepatocellular carcinoma via Rho signaling
Investigator(s):Pang RWC, Kwong YL, Tse EWC
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2010


Project Title:A study on the functional role of a novel focal adhesion protein Actopaxin and its potential regulation by Pin1 in hepatocellular carcinoma
Investigator(s):Pang RWC
Department:Surgery
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012




Researcher : Pang RWC
Project Title:Study of a novel role of Pin1 in regulating invasiveness and metastasis of hepatocellular carcinoma via Rho signaling
Investigator(s):Pang RWC, Kwong YL, Tse EWC
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2010


Project Title:A study on the functional role of a novel focal adhesion protein Actopaxin and its potential regulation by Pin1 in hepatocellular carcinoma
Investigator(s):Pang RWC
Department:Surgery
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012




Researcher : Pang SYY
List of Research Outputs

Ho W.L., Pang S.Y.Y., Li M., Tse H.M., Kung M.H.W., Sham P.C. and Ho S.L., PMCA4 (ATP2B4) mutation in familial spastic paraplegia causes delay in intracellular calcium extrusion, Brain and Behavior. 2015, 5: n/a-n/a.
Lee J.C.Y., Pang S.Y.Y., Tse C.T.A., Lau G.K.K., Chang S.K.R., Teo K.C. and Chan K.H., Thymomatous myasthenia gravis in Hong Kong Chinese, 20th Medical Research Conference, Department of Medicine, HKU. 2015.
Li M., Ho W.L., Pang S.Y.Y., Tse H.M., Kung M.H.W., Sham P.C. and Ho S.L., PMCA4 (ATP2B4) Mutation in Familial Spastic Paraplegia, PLoS ONE. 2014.
Yao N., Cheung C., Pang S.Y.Y., Chang S.K.R., Lau G.K.K., Suckling J., Yu K., Mak H.K.F., Chua S.E., Ho S.L. and McAlonan G.M., Multimodal MRI of the hippocampus in Parkinson's disease with visual hallucinations, Brain Structure and Function. 2014.


Researcher : Pau HYN
List of Research Outputs

Lee C.H.P., Woo Y.C., Fong C., Pau H.Y.N., Lam K.S.L. and Tan K.C.B., Validation of the Pooled Cohort Equations in a Hong Kong Chinese Cohort., 17th International Symposium on Atherosclerosis, Amsterdam, May 2015.


Researcher : Pei D
List of Research Outputs

Bao X., Wu H., Zhu X., Guo X., Hutchins A.P., Luo Z., Song H., CHEN Y., Lai K.W.H., Yin M., Xu L., Zhou L., Chen J., Wang D., Qin B., Frampton J., Tse H.F., Pei D., Wang H. and Zhang B., The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters., Cell Res. 2015. 2015, 25(1): 80-92.
Liu L., Xu Y., He M., Zhang M., Cui F., Lu L., Yao M., Tian W., Benda C., Zhuang Q., Huang Z., Li W., Li X., Zhao P., Fan W., Luo Z., Li Y., Wu Y., Hutchins A.P., Wang D., Tse H.F., Schambach A., Frampton J., Qin B., Bao X., Yao H., Zhang B., Sun H., Pei D., Wang H., Wang J. and Esteban M.A., Transcriptional pause release is a rate-limiting step for somatic cell reprogramming., Cell Stem Cell. . 2014, 15(5): 574-588.
Wu Y., Li Y., Zhang H., Huang Y., Zhao P., Tang Y., Qiu X., Ying L., Li W., Ni S., Zhang M., Liu L., Xu Y., Zhuang Q., Luo Z., Benda C., Song H., Liu B., Lai L., Liu X., Tse H.F., Bao X., Chan W.Y., Esteban M.A., Qin B. and Pei D., 10. Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming., Nat Cell Biol. 2015, 17(6): 715-725.


Researcher : Ran X
List of Research Outputs

Lee Y.K., Ran X., Lai K.W.H., Lau V.Y.M., Siu D.C.W. and Tse H.F., Generation and Characterization of Patient-SpecificInduced Pluripotent Stem Cell Model for Cardiovascular Disease, Springer Protocols. 2015.


Researcher : SAMARANAYAKE NR
List of Research Outputs

SAMARANAYAKE N.R., Cheung D.S., LAM P.S.M., Cheung T.T., Chui W.C., Wong I.C. and Cheung B.M.Y., The effectiveness of a 'Do Not Use' list and perceptions of healthcare professionals on error-prone abbreviations. Epub ahead of print, Int J Clin Pharm. 2014.


Researcher : SHI X
List of Research Outputs

SHI X., HE B., Ma C.H., GUO Y., Chi Y., Zhang W., Zhang Y., Wen Z., Cheng T. and Leung A.Y.H., Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish, Blood. 2015, 125: 2974-2984.


Researcher : SHU L
List of Research Outputs

SHU L., WU X., CHEONG L.Y., Zhou M., Lam K.S.L., Xu A. and Hoo R.L.C., Adipocyte fatty acid binding protein (A-FABP) is a potential regulator of adaptive thermogenesis, Tenth international symposium on healthy aging"A decade of positive aging ". 2015.
Zhou M., PAN Y., SHU L., Lam K.S.L., Xu A. and Hoo R.L.C., A-FABP is a potential mediator of diabetic cardiomyopathy and ischemic reperfusion induced cardiac injury , 17th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM) . 2014.


Researcher : Seto WKW
Project Title:Risk of Hepatitis B Reactivation after Hematopoietic Stem Cell Transplantation in Donors and Recipients with Prior HBV Exposure
Investigator(s):Seto WKW, Kwong YL, Lie AKW, Wong DKH, Lai CL, Yuen RMF
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:02/2013


Project Title:Association between IL-1B, PSCA and MUC1 genes polymorphism with E-cadherin methylation and H. pylori infection to gastric cancer susceptibility
Investigator(s):Seto WKW, Huang FY, Chu KM, Yuen RMF, Leung WK
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2013


Project Title:Provision of serum quantitative hepatitis B surface antigen measurements to optimize disease monitoring and risk stratification of chronic hepatitis B
Investigator(s):Seto WKW, Wong DKH, Fung JYY, Lai CL, Yuen RMF
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:12/2014


List of Research Outputs

Fung J.Y.Y., Wong D.K.H., Seto W.K.W., Kopaniszen M., Lai C.L. and Yuen R.M.F., Hepatitis B Surface Antigen Seroclearance: Relationship to Hepatitis B e-Antigen Seroclearance and Hepatitis B e-Antigen-Negative Hepatitis, The American Journal of Gastroenterology. 2014, 109: 1764-1770.
Fung J.Y.Y., Lam Y.F., Chok K.S.H., Seto W.K.W., Wong C.L.T., Chan A.C.Y., Chan S.C., Lai C.L., Lo C.M. and Yuen R.M.F., Modified model for end stage liver disease score accurately predicts death or liver transplantation in acute flares of chronic hepatitis B, Poster presentaion at the International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2015, 62(Suppl 2): S537.
Huang F.Y., Wong D.K.H., Seto W.K.W., Lai C.L. and Yuen R.M.F., Estradiol activated microrna 23a directly or synergistically with p53 implicated in sex difference in hepatocellular carcinoma development, 24th Annual Conference of APASL, March 12–15, 2015, Istanbul, Turkey. Hepatology International. 2015, 9 (Suppl 1): S137-8.
Hung I.F.N., Wong D.K.H., Poon R.T.P., Fong D.Y.T., Seto W.K.W., Fung J.Y.Y., Yuen J.C.H., Tiu T.M.R.J., Lai C.L. and Yuen R.M.F., Risk Factors and Post-resection Independent Predictive Score for the Recurrence of Hepatitis B-related Hepatocellular Carcinoma, 20th Medical Research Conference 2015, 17 Jan 2015, The University of Hong Kong, Hong Kong.. 2015.
Hung I.F.N., Liu S.H.K., Tan V.P.Y., Hsu A.S.J., Seto W.K.W., Tong S.M. and Leung W.K., Seven-day Rifabutin Containing Triple Therapy Versus Seven-day Levofloxacin Containing Quadruple Therapy as Second-line Treatment for Helicobacter pylori in Chinese Patients: an Open Label, Randomized Trial, Digestive Disease Week 2015. (Oral presentation). 2015, S149.
Lai C.L., Wong D.K.H., Ip P.C.P., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lee B.P., Cullaro G., Wu C.H., Cheng C.T.K., Yuen J.C.H., Ngai W.S. and Yuen R.M.F., Profound Reduction of HBV Covalently Closed Circular DNA with Long-term Nucleoside/tide Analogue Therapy, Hepatology. 2014, 60, No. 4 (Suppl): 183A.
Lam Y.F., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Continuous entecavir for treatment naı¨ve chinese chronic hepatitis B patients in the real world setting the seven year results, 24th Annual Conference of APASL, March 12–15, 2015, Istanbul, Turkey. Hepatology International. 2015, 9 (Suppl 1): S204-5.
Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Liu S.H.K., Singh G.H.H., Lam Y.F., Fung J.Y.Y., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., A prospective study of hepatitis B reactivation in patients with prior HBV exposure undergoing hematopoietic stem cell transplantation: Reactivation association with graft-versus-host disease, Oral presentation at the International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2015, 62(Suppl 2): S194.
Seto W.K.W., AASLD update 2014, Hong Kong Association for the Study of Liver Diseases: Annual Scientific Meeting. 2014.
Seto W.K.W., Advances in therapeutic endoscopy procedures and imaging in GI tract, Postgraduate Diploma in Diagnosis and Therapeutics in Internal Medicine, The University of Hong Kong. 2015.
Seto W.K.W., Lau E.H.Y., Wu J.T.K., Hung I.F.N., Leung W.K., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., An epidemiological association between the trends of nucleoside analogue prescription and liver cancer incidence from 1999 to 2012 in Hong Kong, China, Poster presentation at the International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2015, 62(Suppl 2): S435.
Seto W.K.W., Chronic hepatitis B: Treatment endpoints. 6th WFCMS International Academic Conference of Hepatology, Nanning, China, 2015.
Seto W.K.W., Colon cancer screening - the time is now. Hong Kong-Beijing-Luoyang Medical Forum, Luoyang, China, 2015.
Seto W.K.W., Distinguished Research Paper Award for Young Investigator 2014, Hong Kong College of Physicians. 2014.
Seto W.K.W., Gastric and colon cancer: screening, diagnosis and management, Postgraduate Diploma in Diagnosis and Therapeutics in Internal Medicine, The University of Hong Kong. 2015.
Seto W.K.W., Helicobacter pylori infection in the pediatric population. Practical Pediatric Update Course, Department of Pediatrics and Adolescent Medicine, HKUSZH, Shenzhen, 2015.
Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Hepatitis B reactivation in patients with prior HBV exposure undergoing rituximab-containing chemotherapy for lymphoma: a prospective study, Journal of Clinical Oncology. 2014, 32(33): 3736-43.
Seto W.K.W., Hepatitis B virus reactivation during immunosuppressive therapy: Appropriate risk stratification, World Journal of Hepatology. 2015, 28: 825-830.
Seto W.K.W., Hepatitis and antiviral therapy in hematological malignancies, PRCC of Haemalogical and HSCT nursing. 2014.
Seto W.K.W., Highlights of AASLD 2014. Shenzhen and Hong Kong Second Liver Disease Conference, Shenzhen, 2014.
Seto W.K.W., Liver cirrhosis and gut microbiome. Shenzhen Microbiota Conference, Shenzhen, 2014.
Seto W.K.W., Tanaka Y., Wong D.K.H., Shinkai N., Cheung K.S., Liu S.H.K., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Longitudinal serologic profiles up to 5 years in hepatitis B surface antigen-negative chronic hepatitis B, Hepatology. 2014, 60, No. 4 (Suppl): 57A.
Seto W.K.W., Occult HBV reactivation during immunosuppressive therapy - what is the risk?, 16th Joint Annual Scientific Meeting, Hong Kong Society of Gastroenterology. 2014.
Seto W.K.W., Optimization of H pylori eradication therapy: new insight in 2014. Abbott Shenzhen Digestive Meeting, 2014.
Seto W.K.W., Reactivation of occult hepatitis B during immunosuppressive therapy - what is the risk?, Hong Kong Society of Haematology Scientific Meeting. 2014.
Seto W.K.W., The road to eradication of hepatitis C virus, The Hong Kong Medical Diary: official publication of the Federation of Medical Societies of Hong Kong.. 2015, 20.
Seto W.K.W., Update on viral hepatitis, Shenzhen-Shanghai Liver Forum. 2014.
Seto W.K.W., Use of immunomodulators and biologics for inflammatory bowel disease in Hong Kong The University of Hong Kong – Queen Mary Hospital Inflammatory Bowel Disease Workshop, 2015.
Wong D.K.H., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Zhang J., Hung I.F.N., Lai C.L. and Yuen R.M.F., Identification of Hepatitis B Virus DNA Polymerase Sequences to Predict Virological Response to Entecavir Therapy, Health Research Symposium 2014, Hong Kong, 15 Nov 2014. (Poster presentation). 2014.
Wong D.K.H., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Hung I.F.N., Young J.L.P., Yuen J.C.H., Ngai W.S., Yuen R.M.F. and Lai C.L., Reduction of hepatitis B core related antigen by long term nucleoside nucleotide analogue therapy and its correlation with intrahepatic HBV DNA reduction, 24th Annual Conference of APASL, March 12–15, 2015, Istanbul, Turkey. Hepatology International. 2015, 9 (Suppl 1): S202.
ZHANG A., Wong D.K.H., Huang F.Y., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Evolutionary changes of hepatitis B virus pre-S mutations prior to development of hepatocellular carcinoma, Poster presentation at the International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2015, 62(Suppl 2): S543.


Researcher : Shea YF
List of Research Outputs

Shea Y.F., Lam M.F., Lee M.S., Mok T.M.Y., Lui S.L., Yip T.P.S., Lo W.K., Chu L.W. and Chan D.T.M., Prevalence of CMMSE defined cognitive impairment among peritoneal dialysis patients and its impact on peritonitis, Clinical And Experimental Nephrology. 2015, 21 May 2015: Epub ahead of print.


Researcher : Shek SYN
List of Research Outputs

Chan C.Y.J., Shek S.Y.N., Yeung C.K. and Chan H.H.L., Clinical Efficacy and safety of a novel 755-nm picosecond laser in treatment of pigmentary lesions in Asians, The World Congress of Dermatology 2015 (Vancouver, Canada). 2015.
Chan C.Y.J., Yeung C.K., Shek S.Y.N. and Chan H.H.L., Featured Poster Award, The World Congress of Dermatology 2015 (Vancouver, Canada). 2015.
Chan H.H.L., Yeung C.K. and Shek S.Y.N., Featured Poster Award, The World Congress of Dermatology (2015); Vancouver, Canada.. 2015.
Shek S.Y.N., Chan C.Y.J., Yeung C.K. and Chan H.H.L., Clinical efficacy and safety of a novel dual wavelength 532/1064-nm picosecond laser in treatment of pigmentary lesions in Asians, The World Congress of Dermatology 2015 (Vancouver, Canada). 2015.
Shek S.Y.N., Yeung C.K., Chan P.Y.N., Chan C.Y.J. and Chan H.H.L., Evaluating the safety and efficacy of the 1,440-nm laser in the treatment of photodamage in Asian skin., In: Wiley, Lasers in Surgery and Medicine . Wiley Online Library, 2014, 46: 375-9.
Shek S.Y.N., Yeung C.K. and Chan H.H.L., Featured Poster Award, The World Congress of Dermatology 2015 (Vancouver, Canada). 2015.
Shek S.Y.N., Chan C.Y.J., Yeung C.K. and Chan H.H.L., THE EFFICACY OF A SECOND GENERATION FOCUSED ULTRASOUND COMBINED WITH RADIOFREQUENCY FOR BODY CONTOURING IN CHINESE, The World Congress of Dermatology 2015 (Vancouver, Canada). 2015.


Researcher : Shen J
Project Title:Biochemical Society Meeting 679 University of Essex UK - Stress, Signalling and Control Reactive Oxygen Species Mediate Intracellular Cholesterol Accumulation via Modulating Caveolin-1 Pathway in Chinese Hamster Ovary Cells
Investigator(s):Shen J
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:07/2003


Project Title:Elucidating caveolin-1 as a negative modulating protein for proliferation of neural stem/progenitor cells and neural differentiation in post-ischemic brain
Investigator(s):Shen J, Chung SK, So KF
Department:School of Chinese Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2010


Project Title:Molecular regulations of reactive nitrogen species inhibitors for preventing thrombolysis-induced blood brain barrier disruption and hemorrhagic transformation in experimental cererbal ischemia-reperfersion models
Investigator(s):Shen J, Cheung RTF, Chung SK, Siu DCW, Yang D
Department:School of Chinese Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2011
Completion Date:09/2014


Project Title:Elucidating peroxynitrite as a cellular signaling molecule for regulating proliferation and neuronal differentiation of neural stem/progenitor cells under hypoxic and ischemic conditions
Investigator(s):Shen J, Chung SK, So KF, Yang D
Department:School of Chinese Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:11/2012


Project Title:Elucidating peroxynitrite as a cellular signaling molecule for regulating neurogenesis under hypoxic and ischemic conditions
Investigator(s):Shen J, Yang D, Chen X
Department:School of Chinese Medicine
Source(s) of Funding:National Natural Science Foundation of China (NSFC) - General Program
Start Date:01/2013


Project Title:Exploration of dietary compound isoliquiritigenin in chemosensitizing breast cancer stem cells by targeting aberrant β–catenin signalling
Investigator(s):Shen J, Chen J, Wang Z
Department:School of Chinese Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:11/2013


Project Title:Elucidating effects of APPL2 on regulating proliferation and cell fate decision of neural stem/progenitor cells through activating Notch signaling pathway
Investigator(s):Shen J, So KF, Chung SK
Department:School of Chinese Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2014


Project Title:Roles of Caveolin-1 in Regulating T lymphocytes Infiltration through Blood Brain Barrier in Pathological Process of Experimental Autoimmune Encephalomyelitis
Investigator(s):Shen J, Chan GCF, Wu W
Department:School of Chinese Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2014


Project Title:Exploring Caveolin-1 as a Novel Molecular Target for Hampering T lymphocytes Infiltration through Blood Brain Barrier and Attenuating Disease Progress in Experimental Autoimmune Encephalomyelitis
Investigator(s):Shen J, Chan GCF, Wu W
Department:School of Chinese Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2015


Project Title:Exploring the neuroprotective effect and toxickinetics of An-Gong-Niu-Huang Wan in ischemic rat stroke model
Investigator(s):Shen J
Department:School of Chinese Medicine
Source(s) of Funding:Seed Funding Programme for Applied Research
Start Date:03/2015


Project Title:Elucidating the role of HMGB1in blood brain barrier disruption and hemorrhage transformation in ischemia-reperfused brain with delayed thrombolytic therapy
Investigator(s):Shen J, Chen X, Chung SK
Department:School of Chinese Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2015




Researcher : Shiu SWM
List of Research Outputs

Tan K.C.B., Lee C.H., Shiu S.W.M. and Wong Y., Association between Serum Concentrations of Soluble Lectin-Like Oxidized Low Density Lipoprotein Receptor-1 and Serum Amyloid A in Type 2 Diabetes., The 10th International Diabetes Federation Western Pacific Region Congress, Singapore, Nov 2014.
Tan K.C.B., Shiu S.W.M. and Wong Y., Cellular Expression of Receptors for Circulating Advanced Glycation End Products in Type 2 Diabetes., American Diabetes Association 75th Scientific Sessions, Boston, June 2015.. 2015.
Tsun J.G., Shiu S.W.M., Wong Y. and Tan K.C.B., Impaired Macrophage Cholesterol Efflux in Poorly Controlled Type 2 Diabetes Mellitus., 17th International Symposium on Atherosclerosis, Amsterdam, May 2015.. 2015.
Tsun J.G.S., Yung S.S.Y., Chau K.M., Shiu S.W.M., Chan D.T.M. and Tan K.C.B., Cellular cholesterol transport proteins in diabetic nephropathy, PLoS One. 2014, 9(9): e105787.


Researcher : Sim PYJ
List of Research Outputs

Chim J.C.S., Sim P.Y.J., Tam S., Tse E.W.C., Lie A.K.W. and Kwong Y.L., LDH is an adverse prognostic factor independent of ISS in transplant-eligible myeloma patients receiving bortezomib-based induction regimens, European Journal of Haematology. 2014, n/a-n/a.


Researcher : Singh GHH
Project Title:Mechanisms of leukaemic transformation from myelodysplastic syndromes (MDS) failing treatment with demethylating agents.
Investigator(s):Singh GHH, Kwong YL, Leung AYH
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2015


Project Title:Role of Fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) in relapsed acute promyelocytic leukaemia (APL) treated with oral arsenic trioxide
Investigator(s):Singh GHH, Kwong YL, Leung AYH
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2015


List of Research Outputs

Chan S.Y.T., Hwang Y.Y.G., Singh G.H.H., Cheung C.W.S., Ting A.C.W., Beh S.L., Kwong Y.L. and Tse E.W.C., Increasing incidence of venous thromboembolism due to cancer-associated thrombosis in Hong Kong Chinese, Thrombosis Research. 2014.
Chan T.S., Cheung C.Y., Yeung I.Y., Hwang Y.Y.G., Singh G.H.H., Wong Y.H.I. and Kwong Y.L., Cytomegalovirus retinitis complicating combination therapy with rituximab and fludarabine, Annals of Hematology. 2015.
Hai J.J., Singh G.H.H., Tse H.F., Kumana C.R., Kwong Y.L. and Siu D.C.W., Torsade de Pointes during oral arsenic trioxide therapy for acute promyelocytic leukemia in a patient with heart failure, Annals of Hematology. 2014.
Lee E.Y.P., Singh G.H.H., Wang Y. and Khong P.L., PET/CT in predicting marrow involvement in lymphoma., 15th AOCR, Kobe, Japan. 2014.
Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Liu S.H.K., Singh G.H.H., Lam Y.F., Fung J.Y.Y., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., A prospective study of hepatitis B reactivation in patients with prior HBV exposure undergoing hematopoietic stem cell transplantation: Reactivation association with graft-versus-host disease, Oral presentation at the International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2015, 62(Suppl 2): S194.
Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Hepatitis B reactivation in patients with prior HBV exposure undergoing rituximab-containing chemotherapy for lymphoma: a prospective study, Journal of Clinical Oncology. 2014, 32(33): 3736-43.
Singh G.H.H., Man C.H., Ip H.W., Choi W.L., Chow H.C.H., Kwong Y.L. and Leung A.Y.H., Azacitidine as post-remission consolidation for sorafenib-induced remission of Fms-Like Tyrosine Kinase-3 internal tandem duplication positive acute myeloid leukemia, Haematologica. 2015.
Singh G.H.H., Best Paper Award - the Hong Kong Society of Haematology Annual Scientific Meeting 2015, The Hong Kong Society of Haematology. 2015.
Singh G.H.H., Hwang Y.Y.G., Chan T.S.Y., Chan C.C., Chan C.H.Y., Liu H.S.Y., Mak V., Lin S.Y., Lau C.K., Leung A.Y.H., Lie A.K.W. and Kwong Y.L., Clinicopathologic Features and Outcome of Chinese Patients with Myelofibrosis, 56th ASH Annual Meeting and Exposition, San Francisco, CA.. Blood, 2014, 124 (21).
Singh G.H.H., Chan T.S.Y., Hwang Y.Y.G., Leung A.Y.H., Tse E.W.C. and Kwong Y.L., Clofarabine And High-dose Cytarabine Arabinoside (clara) For Primary Refractory Or Relapsed Acute Myeloid Leukaemia – A Prospective Follow-up Study Of 60 Patients, 20th Congress of the European Haematology Association, Vienna, 11 - 15 June 2015.. 2015.
Singh G.H.H., Ip H.W., Pang A.W.K., Sum C.Y., Leung A.Y.H. and Kwong Y.L., FLT3 internal tandem duplication in acute promyelocytic leukemia: central nervous system relapse, Annals of Hematology. 2014.
Singh G.H.H., Highest Score in Advanced Internal Medicine Exit Assessment, Hong Kong College of Physicians. 2014.
Singh G.H.H., Myelofibrosis - Current Data, The First Myeloproliferative Neoplasm (MPN) Working Group Meeting. 2014.
Singh G.H.H., Myeloproliferative neoplasms - current concepts and treatment, 15th HKCMN Educational Seminar. 2014.
Singh G.H.H., Au W.Y., Cheung W.W., Lee E.Y.P. and Kwong Y.L., Oral arsenic trioxide-based regimen as salvage treatment for relapsed or refractory mantle cell lymphoma, Annals of Oncology. 2014, 25: 1391-1397.
Singh G.H.H., Leung A.Y.H., Tse E.W.C. and Kwong Y.L., Relapse Characteristics And Risk Factors For Central Nervous System Involvement In Acute Promyelocytic Leukaemia In The Oral Arsenic Trioxide Era – A 13-year Follow-up Study, 20th Congress of the European Haematology Association, Vienna, June 11 - 15, 2015.. Haematologica, 2015.


Researcher : Siu DCW
Project Title:Dynamic Conformational Changes of the P-S6 linker of the Pacemaker (HCN) Channels Identified by Sulfhydryl Modification: Pore-to-Gate Coupling Model
Investigator(s):Siu DCW, Tse HF
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:10/2008


Project Title:Human Induced Pluripotent Stem Cells as a Disease Modeling and Drug Screening Platform for Friedreich Ataxia
Investigator(s):Siu DCW, Ho WL, Tse HF
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:07/2012


Project Title:Cardiac fibroblasts derived Human induced pluripotent cells for cardiac regeneration
Investigator(s):Siu DCW, Tse HF
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2014


List of Research Outputs

Chan P.H.M., Li W., Hai S.H.J.J., Tse H.F. and Siu D.C.W., Impact of Antithrombotic Therapy in Atrial Fibrillation on the Presentation of Coronary Artery Disease, PLOS ONE. 2015, 10: e0131479.
Chan P.H.M., Hai S.H.J.J. and Siu D.C.W., Response to Letter Regarding Article, "Ischemic Stroke and Intracranial Hemorrhage With Aspirin, Dabigatran, and Warfarin: Impact of Quality of Anticoagulation Control", Stroke. 2015, 46: e72-e72.
Chan Y.H., Lau K.K., Yiu K.H., Li L.S.W., Tam S., Lam T.H., Lau C.P., Siu D.C.W., Cheung B.M.Y. and Tse H.F., Vascular protective effects of statin-related increase in serum 25-hydroxyvitamin D among high-risk cardiac patients, Journal of Cardiovascular Medicine. 2015, 16: 51-58.
Chan Y.H., Lau G.K.K., Yiu K.H., Li L.S.W., Tam S., Lam T.H., Lau C.P., Siu D.C.W., Cheung B.M.Y. and Tse H.F., Vascular protective effects of statin-related increase in serum 25-hydroxyvitamin D among high-risk cardiac patients, Journal of Cardiovascular Medicine (Hagerstown). 2015.
Guo Y., Chung S.K., Siu D.C.W., Kwan S.C., Ho W.L., Yeung P.K.K. and Chan K.H., Endothelin-1 overexpression exacerbate experimental allergic encephalomyelitis, Journal of Neuroimmunology. 2014.
Hai J.J., Singh G.H.H., Tse H.F., Kumana C.R., Kwong Y.L. and Siu D.C.W., Torsade de Pointes during oral arsenic trioxide therapy for acute promyelocytic leukemia in a patient with heart failure, Annals of Hematology. 2014.
Hai S.H.J.J., Chan P.H.M., Tse H.F. and Siu D.C.W., Slow Heart Rate Predicts New Occurrence of Atrial Fibrillation, Heart, Lung and Circulation. 2015.
Ho C.W., Ho M.H., Chan P.H.M., Hai S.H.J.J., Cheung E., Yeung C.Y., Lau G.K.K., Chan K.H., Lau C.P., Lip G.Y., Leung G.K.K., Tse H.F. and Siu D.C.W., Ischemic stroke and intracranial hemorrhage with aspirin, dabigatran, and warfarin: impact of quality of anticoagulation control, Stroke. 2015.
Ho M.H., Ho C.W., Cheung E., Chan P.H.M., Hai J.J., Chan K.H., Chan E.W., Leung G.K.K., Tse H.F. and Siu D.C.W., Continuation of Dabigatran Therapy in “Real-World” Practice in Hong Kong, PLoS ONE. 2014, 9(8): e101245.
Huang D., Anguo L., Yue W.S., Yin L., Tse H.F. and Siu D.C.W., Refinement of Ischemic Stroke Risk in Patients with Atrial Fibrillation and CHA2 DS2 -VASc Score of 1., Pacing Clin Electrophysiol. 2014 Jul 16. 2014.
Lee Y.K., Ran X., Lai K.W.H., Lau V.Y.M., Siu D.C.W. and Tse H.F., Generation and Characterization of Patient-SpecificInduced Pluripotent Stem Cell Model for Cardiovascular Disease, Springer Protocols. 2015.
Liao S., Liu Y., Zhang Y., Au K.W., Lai K.W.H., Siu D.C.W. and Tse H.F., Remodelling of cardiac sympathetic re-innervation with thoracic spinal cord stimulation improves left ventricular function in a porcine model of heart failure., Europace. 2015, 2105 MAR 12: 409.
NG A.K.Y., Ng K.M., Tse H.F., Lai K.W.H., CHAN W.S., Siu D.C.W. and Fan K., Pseudo-Pre-Excitation Unraveled Down to Its Core, Circulation. 2014, 130: e56-e58.
Santoso T., Siu D.C.W., Irawan C., Chan W.S., Alwi I., Yiu K.H., Aziz A., Kwong Y.L. and Tse H.F., Endomyocardial Implantation of Autologous Bone Marrow Mononuclear Cells in Advanced Ischemic Heart Failure: a Randomized Placebo-Controlled Trial (END-HF)., J Cardiovasc Transl Res. 2014.
Siu D.C.W., Invited Speaker, 3rd International Symposium of Materials on Regenerative Medicine, Taipei, Taiwan , , “Regeneration of Cardiac Conducting System”. 2014.
Siu D.C.W., 2014 Invited Speaker, Asian Thrombosis Forums, Taiwan, “Finding useful tool for risk stratification in Chinese patients with Atrial Fibrillation.”, 2014.
Siu D.C.W., 2014 Public Talk” HKU Faculty, "心律不整中風誘因?. 2014.
Siu D.C.W., 2014 香港電台 "香江暖流—健康是福」訪問主題：心房纖維性顫動 環節：健康是福 . 2014.
Siu D.C.W., 2014Interviewee,明報健康版[家庭醫生睇醫生]：心律不正. 2014.
Siu D.C.W., 2015 HKU performs the first-in-man restorative treatment – the dual-targeted thoracic spinal cord stimulation for heart failure, 2015.
Siu D.C.W., 2015 Invited Speaker, Asia Bayer Clinical Day – Cardiology Translational Research Workshop, Tokyo, Japan,, 2015.
Siu D.C.W., 2015 Invited Speaker, Continuing Medical Education Meeting at Chongqing and Beijing, “ Practical case sharing on Dabigatran,”, 2015.
Siu D.C.W., 2015 Invited Speaker, Interaction Summit in SPAF across mainland China, Taiwan and HK , Beijing and Continuing Medical Education Meeting “Ischemic Stroke & ICH with ASA, VKA & Dabigatran, 2015.
Siu D.C.W., 2015 Invited Speaker, PHA Annual Convention, Manila, Philippines ,” Apixaban: from Innovation to clinical realtiy, 2015.
Siu D.C.W., Cardiac Arrhythmias: From Slow to Fast, From Patients, Genes to Stem cells, From a Clinician to a Basic Scientist, Sir David Todd Lecture 2015. 2015.
Siu D.C.W., HKU Press,, Radiofrequency Ablation as a New and Effective Surgical Treatment for Atrial Fibrillation, 2015.
Siu D.C.W., HKU Press,” HKU developed the atrial fibrillation (AF) management apps and Launch of HKU –private doctors AF screening programme, 2015.
Siu D.C.W., Interviewee, Ferring Pharmaceuticals Ltd, CV risk of current Androgen Deprivation Therapy (ADT) Management on Prostate cancer, 2014.
Siu D.C.W., Interviewee, China Daily about the “Ice Bucket Challenge, 2014.
Siu D.C.W., Interviewee, Metro studio, “ 香港心房纖顫的情況”, 2014.
Siu D.C.W., Interviewee, Oriental Daily, “Treatment for Nonmetastatic Carcinoma of Prostate”, 2014.
Siu D.C.W., Interviewee, PLUS 創意傳訊 on behalf of TVB : atrial fibrillation, 2014.
Siu D.C.W., Interviewee, PRPPL Consultancy Limited, “GP AF Program”, 2015.
Siu D.C.W., Interviewee, SCMP health editor, subcutaneous implantable cardioverter defibrillator, 2014.
Siu D.C.W., Interviewee, Sing Pao / 22 Plus PR agency, WHD 2014 Media Interview - Singpao Heart Disease, 2014.
Siu D.C.W., Interviewee,有線新聞 《至FIT男女》節目拍攝香港男士健康系列」之「男士心臟病」, 2014.
Siu D.C.W., Invited Speaker, 17th China Rhythm Society(Beijing & China), ”Practical tips in managing inpatients on NOAC”, 2015.
Siu D.C.W., One more "C" for CHA2DS2-VASc score?, J am Coll Cardiology 2015. 2015, 65(15): 1602-1603.
Siu D.C.W., Stroke Prevention in Atrial Fibrillation Amongst Chinese: a Not-to missed Opportunity , Hong Kong Heart Foundation Lecture, Annual Scientific Meeding of Hong Kong College of Cardiology. 2015.
Tse H.F., Turner S., Sanders P., Okuyama Y., Fujiu K., Cheng C.W., Russo M., Green M.D., Yiu K.H., Chen P., Shunto C., Lau E.O. and Siu D.C.W., Thoracic Spinal Cord Stimulation for Heart Failure as a Restorative Treatment (SCS HEART study): first-in-man experience, Heart Rhythm. 2015, 12(3): 588-595.
WONG C.K.A., CHEN Y., HO L.M., ZHEN Z., Siu D.C.W., Tse H.F. and Yiu K.H., Angiographic result of T-stenting with small protrusion using drug-eluting stents in the management of ischemic side branch: the ARTEMIS study., Nutr Metab Cardiovasc Disorder 2014. 2014.


Researcher : Siu SC
List of Research Outputs

Wong C.K.H., JIAO F., Siu S.C., Fung S.C.C., Wong K.W. and Lam C.L.K., Cost-Effectiveness of A Short Message Service (Sms) Intervention To Prevent Type 2 Diabetes Among Adults With Impaired Glucose Tolerance, Value in Health. 2014, 17: A348.
Wong C.K.H., Siu S.C., Wan Y.F., JIAO F., Yu Y.T.E., Fung S.C.C., Wong K.W. and Lam C.L.K., Simple Non-laboratory-based and Laboratory-based Risk Assessment Algorithms and Nomogram for Detecting Undiagnosed Diabetes Mellitus, The 10th International Diabetes Federation-Western Pacific Regions Congress (IDF-WPR) & the 6th Asian Association for the Study of Diabetes (AASD) Meeting. Singapore, 2014, 110.
Wong C.K.H., Siu S.C., Wan Y.F., JIAO F., Yu Y.T.E., Fung S.C.C., Wong K.W., Leung A.Y.M. and Lam C.L.K., Simple non-laboratory- and laboratory-based risk assessment algorithms and nomogram for detecting undiagnosed diabetes mellitus, Journal of Diabetes. Shanghai Jiaotong University, Wiley Publishing Asia Pty Ltd, 2015.


Researcher : Sum CY
List of Research Outputs

Singh G.H.H., Ip H.W., Pang A.W.K., Sum C.Y., Leung A.Y.H. and Kwong Y.L., FLT3 internal tandem duplication in acute promyelocytic leukemia: central nervous system relapse, Annals of Hematology. 2014.


Researcher : Sun H
List of Research Outputs

Yang L., Liu H., Sun H. and Li G.R., Intravenous Anesthetic Propofol Inhibits Multiple Human Cardiac Potassium Channels, Anesthesiology. 2014, 122(3): 571-84.


Researcher : TAM CY
List of Research Outputs

TAM C.Y., Yang W., Lau W.C.S. and Chan V.S.F., Systemic Lupus Erythematosus Patients Exhibit Reduced Expression of CLEC16A Isoforms in Peripheral Leukocytes, International Journal of Molecular Sciences. Basel, Switzerland, MDPI AG, 2015, 16: 14428-14440.


Researcher : TSOI MF
List of Research Outputs

Cheung T.T., TSOI M.F. and Cheung B.M.Y., Effect of TNF inhibitors on subclinical atherosclerosis in patients with rheumatoid arthritis: a meta-analysis, Annual European Congress of Rheumatology 2015.
Cheung T.T., TSOI M.F. and Cheung B.M.Y., Inorganic mercury poisoning due to the use of beauty cream in Hong Kong , 12th Congress of the European Association for Clinical Pharmacology and Therapeutics. 2015.


Researcher : Tam CC
List of Research Outputs

Lee S.W.L., Lam S.C.C., Kong S.L., Chan K.W.K., Tam C.C., Wong K.L., Wong A.Y.T., Yung A.S.Y., Shea C.P., Zhang L. and Wu K.Y.K., TCT-367 2-Year Sequential OCT Follow-up Findings and 3-Year Clinical Outcomes of the New Dual Therapy Endothelial Progenitor Cell Capturing Sirolimus-eluting COMBO Stent: The EGO-COMBO Study, Journal of the American College of Cardiology. 2014, 64: B107.


Researcher : Tam CCT
List of Research Outputs

Lam C.L.D., Tam C.C.T., Lau K.M., Wong W.M., Hui K.M.C., Lam J.C., Wang J.K., Lui M.S.M., Ho J.C.M. and Ip M.S.M., Plasma EGFR Mutation Detection Associated With Survival Outcomes in Advanced-Stage Lung Cancer, Clinical Lung Cancer [Epub ahead of print]. 2015.


Researcher : Tam SKF
List of Research Outputs

Tam S.K.F., Lee N.Y.M. and Wong G.H.Y., Practical approach to pharmacological treatment and nonpharmacological intervention of dementia, CME Bulletin. 2014.


Researcher : Tan KCB
Project Title:Advanced glycation end product receptors in diabetes
Investigator(s):Tan KCB
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2013


Project Title:Genetic Screening of Familial Hypercholesterolemia in Hong Kong
Investigator(s):Tan KCB, Yeung CY, Siu DCW, Leung YYJ, Pang HK, Cheung CL
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2014


Project Title:17th International Symposium on Atherosclerosis; Validation of the Pooled Cohort Equations in a Hong Kong Chinese Cohort
Investigator(s):Tan KCB
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:05/2015


List of Research Outputs

Chau T.K., Fong D.Y.T., Chan S.S.C., Wong J.Y.H., Li W.H.C., Tan K.C.B., Leung A.Y.M., Wong D.T.W., Leung D.Y.P. and Lam T.H., Misconceptions about smoking in patients with type 2 diabetes mellitus: A qualitative analysis (abstract), The 7th Cross-Strait Conference on Tobacco Control, 2-3 September 2014, Hong Kong. Hong Kong, COSH, 2014.
Cheung T.T., Cheung C.L., Tan K.C.B., Leung Y.H. and Cheung B.M.Y., People With Peripheral Arterial Disease And Diabetes Are Associated With Clinically Significant Weakness , International conference on diabetes and metabolism. 2014.
Lam K.Y.J., Lam K.S.L., Chow W.S. and Tan K.C.B., A middle-aged man with increasing body fat, Clinical Obesity. 2014, n/a-n/a.
Lee C.H.P., Woo Y.C., Fong C., Pau H.Y.N., Lam K.S.L. and Tan K.C.B., Validation of the Pooled Cohort Equations in a Hong Kong Chinese Cohort., 17th International Symposium on Atherosclerosis, Amsterdam, May 2015.
Li R.H.W., Cheung C.L., Tan K.C.B., Sham P.C., Kung A.W.C. and Tang G.W.K., Replication study of genetic loci influencing age at menopause in Southern Chinese women., The 10th European Congress on Menopause and Andropause, Madrid, May 2015.
Sing C.W., Lui V.W.Y., Sham P.C., Tan K.C.B., Kung A.W.C., Wong I.C.K., Cheung B.M.Y., Chan J.C.Y. and Cheung C.L., JAG1 Polymorphism is Associated with Incident Neoplasm., 23rd Annual International Genetic Epidemiology Society, Vienna, Aug 2014.
Tan K.C.B., A member of the Editorial Board, The Lancet Diabetes & Endocrinology (HK Edition). 2015.
Tan K.C.B., Associate Editor of Clinical Obesity, International Association for the Study of Obesity. 2015.
Tan K.C.B., Lee C.H., Shiu S.W.M. and Wong Y., Association between Serum Concentrations of Soluble Lectin-Like Oxidized Low Density Lipoprotein Receptor-1 and Serum Amyloid A in Type 2 Diabetes., The 10th International Diabetes Federation Western Pacific Region Congress, Singapore, Nov 2014.
Tan K.C.B., Shiu S.W.M. and Wong Y., Cellular Expression of Receptors for Circulating Advanced Glycation End Products in Type 2 Diabetes., American Diabetes Association 75th Scientific Sessions, Boston, June 2015.. 2015.
Tan K.C.B., Facing the challenges in the management of type 2 diabetes with co-morbidities, Symposium of the Diabetic Society of Singapore, Aug 2014, Singapore. 2014.
Tan K.C.B., Insulin intensification, National University Hospital, Aug 2014, Singapore.. 2014.
Tan K.C.B., Managing type 2 diabetes in complex patients with comorbid disease – the role of DPP4 inhibitors, CME Meeting for Physicians, Mount Elizabeth Medical Centre, Aug 2014, Singapore. 2014.
Tan K.C.B., Non-Insulin Dependent Pathway – A Novel Way to Control Excess Glucose, Tenth International Symposium on Healthy Aging, Mar 2015, Hong Kong. 2015.
Tan K.C.B., Role of the Advanced Glycation End Products Pathway in Atherosclerosis, Congress of the Asian-Pacific Society of Atherosclerosis and Vascular Diseases, Sept 2014, Hong Kong. 2014.
Tsun J.G., Shiu S.W.M., Wong Y. and Tan K.C.B., Impaired Macrophage Cholesterol Efflux in Poorly Controlled Type 2 Diabetes Mellitus., 17th International Symposium on Atherosclerosis, Amsterdam, May 2015.. 2015.
Tsun J.G.S., Yung S.S.Y., Chau K.M., Shiu S.W.M., Chan D.T.M. and Tan K.C.B., Cellular cholesterol transport proteins in diabetic nephropathy, PLoS One. 2014, 9(9): e105787.


Researcher : Tan V.P.Y.
Project Title:Prevalence of Fermentable Oligo-, Di- and Mono- saccharides and Polyols (FODMAPS) malabsorption in Chinese Control, Functional Dyspepsia, Irritable Bowel and Inflammatory Bowel Disease Patients
Investigator(s):Tan VPY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2011


Project Title:Influence of phytochemicals present in plant based supplementation on stool microbiota of control versus colon cancer subjects: A feasibility study
Investigator(s):Tan VPY, Panagiotou I, Dufay S, Poon TCJ
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2014


List of Research Outputs



Researcher : Tan VPY
Project Title:Prevalence of Fermentable Oligo-, Di- and Mono- saccharides and Polyols (FODMAPS) malabsorption in Chinese Control, Functional Dyspepsia, Irritable Bowel and Inflammatory Bowel Disease Patients
Investigator(s):Tan VPY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2011


Project Title:Influence of phytochemicals present in plant based supplementation on stool microbiota of control versus colon cancer subjects: A feasibility study
Investigator(s):Tan VPY, Panagiotou I, Dufay S, Poon TCJ
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2014


List of Research Outputs

Hung I.F.N., Liu S.H.K., Tan V.P.Y., Hsu A.S.J., Seto W.K.W., Tong S.M. and Leung W.K., Seven-day Rifabutin Containing Triple Therapy Versus Seven-day Levofloxacin Containing Quadruple Therapy as Second-line Treatment for Helicobacter pylori in Chinese Patients: an Open Label, Randomized Trial, Digestive Disease Week 2015. (Oral presentation). 2015, S149.
Tan V.P.Y., Wong B.C.Y., Wong R.W.M., Leung W.K., Tong D.K.H., Yuen R.M.F. and Fass R., Gastroesophageal reflux disease: cross-sectional study demonstrating rising prevalence in a Chinese population, J Clin Gastroenterol. 2015, Epub ahead of print.
Tan V.P.Y., Wong I.W. and Lee Y.T., Novel Use Of Cap-assisted Enteroscopy For Detection Of Colorectal Tumor In A Patient With Incarcerated Inguinal Hernia., In: Juan Manuel Herrerias Gutierrez Atsushi Imagawa, World Journal of Gastrointestinal Endoscopy. China, Baishideng Publishing Group, 2014, 6: 510-2.
Tan V.P.Y., Liu S.H.K., Lam Y.F., Hung I.F.N., Yuen R.M.F. and Leung W.K., Rifaximin for the Treatment of Functional Dyspepsia: A Double-Blind Randomized Placebo-Controlled Trial., Digestive Diseases Week 2015.


Researcher : Tang CW
Project Title:Provision of free mycophenolate mofetil for IgA nephropathy patients with persistent proteinuria despite maximal angiotensin blockade therapy in Hong Kong
Investigator(s):Tang SCW, Lai KN
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:08/2010


Project Title:Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-label pilot study
Investigator(s):Tang SCW, Lai KN
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:10/2010


Project Title:Exploring the role of the kallikrein-kinin system in diabetic nephropathy
Investigator(s):Tang SCW, Yiu WH
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2012


Project Title:King's/HKU Fellowship Awards 2012-13
Investigator(s):Tang SCW
Department:Medicine
Source(s) of Funding:King's/HKU Fellowship Awards
Start Date:07/2012


Project Title:Exploring the role of bone marrow-derived mesenchymal stromal/stem cells in nephropathies
Investigator(s):Tang SCW, Tse HF
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2013


Project Title:Wnt/beta-catenin signaling in kidney proximal tubular cells
Investigator(s):Tang SCW
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2014


Project Title:American Society of Nephrology Kidney Week 2014; Prevalence and Severity of Sleep Apnea in Different Stages of Chronic Kidney Disease
Investigator(s):Tang SCW
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:11/2014
Completion Date:11/2014


Project Title:Using Reprogrammed Mesenchymal Stem Cells in Diabetic Nephropathy
Investigator(s):Tang SCW, Liu Y
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2015


List of Research Outputs



Researcher : Tang SCW
Project Title:Provision of free mycophenolate mofetil for IgA nephropathy patients with persistent proteinuria despite maximal angiotensin blockade therapy in Hong Kong
Investigator(s):Tang SCW, Lai KN
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:08/2010


Project Title:Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-label pilot study
Investigator(s):Tang SCW, Lai KN
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:10/2010


Project Title:Exploring the role of the kallikrein-kinin system in diabetic nephropathy
Investigator(s):Tang SCW, Yiu WH
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2012


Project Title:King's/HKU Fellowship Awards 2012-13
Investigator(s):Tang SCW
Department:Medicine
Source(s) of Funding:King's/HKU Fellowship Awards
Start Date:07/2012


Project Title:Exploring the role of bone marrow-derived mesenchymal stromal/stem cells in nephropathies
Investigator(s):Tang SCW, Tse HF
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2013


Project Title:Wnt/beta-catenin signaling in kidney proximal tubular cells
Investigator(s):Tang SCW
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2014


Project Title:American Society of Nephrology Kidney Week 2014; Prevalence and Severity of Sleep Apnea in Different Stages of Chronic Kidney Disease
Investigator(s):Tang SCW
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:11/2014
Completion Date:11/2014


Project Title:Using Reprogrammed Mesenchymal Stem Cells in Diabetic Nephropathy
Investigator(s):Tang SCW, Liu Y
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2015


List of Research Outputs

CHAN G.C.W. and Tang S.C.W., Diabetic Nephropathy: landmark clinical trials and tribulations, Nephrology Dialysis Transplantation [Invited Review; IF 3.577]. 2015, 0: 1-10.
CHAN G.C.W. and Tang S.C.W., Prevalence and Severity of Sleep Apnea in Different Stages of Chronic Kidney Disease, J Am Soc Nephrol. 2014, 25: 251A.
Chan G.C.W., Yap Y.H.D., Kwan L.P., Chan J.F.W., Iu L.P.L., Wong Y.H.I. and Tang S.C.W., Progressive outer retinal necrosis in a renal transplant recipient: a rare treatment success, Transplant Infectious Disease. 2015, 17: 396-399.
Chen J.Y., Tsang J.P.Y., Lui S.L., Lo W.K., Tang S.C.W., Chan D.T.M. and Lam C.L.K., The illness experience of end stage renal disease patients in Hong Kong undergoing hemodialysis, Communication, Ethics and Medicine (COMET) conference. 2015.
Cheung T.S., SONG T., Ng T.B., Wu F.H., Lao L., Tang S.C.W., Ho J.C.M., Zhang Y. and Sze C.W.S., Therapeutic Effects of Herbal Chemicals in Traditional Chinese Medicine on Alzheimer's Disease, Curr Med Chem . 2015, 22: 2392-2403.
Kwan S.K.J., Chu L.W., Chan H.W.F., Lee T.M.C., Law A.C.K., Mak H.K.F., Cheung R.T.F., Chang R.C.C., Lum T.Y.S. and Tang S.C.W., Comparing vascular dementia and Alzheimer’s dementia: a preliminary, cross-sectional, multimodal comparative study evaluating clinical and cognitive profile, neuroimaging, biomarkers and quantitative EEG ($240,000), Seed Funding HKU. 2014.
LI R., Yiu W.H., Wu H., LIN M., WONG W.L.D., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., BMP7 Reduces Tubular Inflammation and Oxidative Stress in Diabetic Nephropathy, J Am Soc Nephrol. 2014, 25: 216A.
LI R., Yiu W.H., Wu H., WONG W.L.D., Chan Y.Y., LIN M., Leung J.C.K., Lai K.N. and Tang S.C.W., BMP7 reduces inflammation and oxidative stress in diabetic tubulopathy, Clinical Science [IF 5.629]. 2015, 128(4): 269-280.
LI R., Yiu W.H. and Tang S.C.W., Role of bone morphogenetic protein-7 in renal fibrosis, Frontiers Physiology [IF 3.534]. 2015, 6: 114.
LIU J., CHEN X., Tang S.C.W., Lao L., Sze C.W.S., Lee C.K.F. and Zhang Y., Edible plants from traditional Chinese medicine is a promising alternative for the management of diabetic nephropathy, In: Jing-Yi Liu, Xiao-Xin Chen, Sydney Chi-Wai Tang, Li-Xing Lao, Stephen Cho-Wing Sze, Kai-Fai Lee, Yanbo Zhang, Journal of Functional Foods [IF 4.48]. 2015, 14(2015): 12-22.
LIU J., Tang S.C.W., Sze C.W.S., Lao L., Ho J.C.M., Lee C.K.F. and Zhang Y., Paper and poster presentation: Traditional Chinese Medicine is a Promising Alternative for the Management of Diabetic Nephropathy. , In: Liu JY, Tang SCW, Sze SCW, Lao LX, Ho JCM, Lee CKF, Zhang YB*. , The 8th Pong Ding Yuen International Symposium on Traditional Chinese Medicine cum, The 2nd International Chinese Symposium on Free Radical Research & The 6th Symposium for Three Districts of Cross-straits on Free Radical Research 15 -16/11/2014, Hong Kong. Organized by Commission of Free Radical Biology and Medicine, Biophysical Society of China and Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2014.11.15-16. . 2014, p-60.
Lai K.N., Leung J.C.K. and Tang S.C.W., The treatment of IgA nephropathy, Kidney Dis . 2015.
Lim A.I., Chan Y.Y., Tang S.C.W., Lai K.N. and Leung J.C.K., Albumin and glycated albumin activate KIM-1 release in tubular epithelial cells through distinct kinetics and mechanisms, Inflammation Research [Epub ahead of print]. 2014.
SONG T., Sze C.W.S., Ng T.B., Tang S.C.W., Ho J.C.M. and Zhang Y., Session 3 Chairman. Speaking and abstract: Investigation of Effect Mechanisms and Clinical Study of Polysaccharide of Dendrobium officinale in Alleviating Cigarette-Induced COPD. , In: Song TH, Sze CW, Ng TB, Tang CW, Ho CM, Zhang YB*. , Shanghai, China. Co-organized by the Phytochemical Society of Europe and the Phytochemical Society of Asia. Jun 26-29, 2015. . 2015, p-18.
Tang S.C.W., "Basic Research in Nephrology", 16th Asia Renal Association-Asian Nephrology Conference (ARA-ANC), Kaohsiung, Taiwan (Could not attend due to sickness). 2015.
Tang S.C.W., "Burden of Disease - Prevalence and incidence of End-Stage Renal Disease in Southeast Asia", ISN 2015 World Congress of Nephrology Satellite Symposium titled "Challenges of Practice in a Resource Limited Environment. Focus on Africa", Cape Town, South Africa. 2015.
Tang S.C.W., "Diabetic Nephropathy in Asia: A Growing Threat", in a symposium entitled "Common Kidney Diseases in the Aging Population", Tenth International Symposium on Healthy Aging "A Decade of Positive Aging", Hong Kong. 2015.
Tang S.C.W., "Diabetic nephropathy in Asia: A global and growing threat", ISN World Congress of Nephrology, Cape Town, South Africa [prestigious academic international conference in nephrology]*. 2015.
Tang S.C.W., "Treatment of diabetic nephrolpathy in stage G4-G5", 9th Asian Forum of Chronic Disease Initiatives (AFCKDI), Jakarta, Indonesia. 2015.
Tang S.C.W., A tribute to Hai-Yan Wang, Hong Kong Journal of Nephrology. 2015, 17(1): 6-7.
Tang S.C.W., Yiu W.H., LIN M. and Lai K.N., Diabetic Nephropathy and Proximal Damage, Journal of Renal Nutrition [IF 2.548]. 2015, 25(2): 230-233.
Tang S.C.W., Nephrology, Deputy Editor-in-chief. Wiley-Blackwell, 2014.
Yiu W.H., WONG W.L.D., Leung J.C.K., Chan Y.Y., Lai K.N. and Tang S.C.W., Thrombin Induces Epithelial-Mesenchymal Transition Through the Activation of PAR-1 in Tubular Epithelial Cells, J Am Soc Nephrol. 2014, 25: 730A.
Yiu W.H., LIN M. and Tang S.C.W., Toll-like receptor activation: from renal inflammation to fibrosis, Kidney International Supplements. 2014, 4(1): 20-25.
Zhang Y., Sze C.W.S., Tang S.C.W., Ho J.C.M., SONG T. and LIU J., Invention of Efficacy on Polysaccharide of Dendrobium officinale in Alleviating Cigarette-Induced Pulmonary Inflammation Though Experimental Rats. , In: Zhang YB*, Sze CW, Tang CW, Ho CW, Song TH, Liu JY., China patent office. 2014.


Researcher : Tang SOC
List of Research Outputs

Yap Y.H.D., Yung S.S.Y., Zhang Q., Tang S.O.C. and Chan D.T.M., Mesangial cell-binding activity of serum immunoglobulin G in patients with lupus nephritis, PLoS One. 2014, 9(7): e101987.
Yung S.S.Y., Lui S.L., Ng K.F., Yim A.S.Y., Ma K.M.M., Lo W.K., Chow C.C., Chu K.H., Chak W.L., Lam M.F., Yung C.Y., Yip T.P.S., Wong S., Tang S.O.C., Ng F.S.K. and Chan D.T.M., Impact of a Low-Glucose Peritoneal Dialysis Regimen on Fibrosis and Inflammation Biomarkers, Peritoneal Dialysis International. 2015, 35: 147-158.


Researcher : Tiu TMRJ
List of Research Outputs

Hung I.F.N., Wong D.K.H., Poon R.T.P., Fong D.Y.T., Seto W.K.W., Fung J.Y.Y., Yuen J.C.H., Tiu T.M.R.J., Lai C.L. and Yuen R.M.F., Risk Factors and Post-resection Independent Predictive Score for the Recurrence of Hepatitis B-related Hepatocellular Carcinoma, 20th Medical Research Conference 2015, 17 Jan 2015, The University of Hong Kong, Hong Kong.. 2015.


Researcher : Tong SM
List of Research Outputs

Chan E.W., LAU C.Y., Leung W.K., Mok T.C., HE Y., Tong S.M. and Wong I.C.K., Effectiveness of gastroprotective agents on prevention of dabigatran related gastrointestinal bleeding: a population-based retrospective cobort study, 14th ISoP Annual Meeting "New Ideas in Ancient Cultures: Advancing Pharmacovigilance in Asia", 19-22 October 2014, Tianjin China. 2014.
Chan E.W., Lau C.Y., Leung W.K., Mok M.T.C., He Y., Tong S.M. and Wong I.C.K., Prevention of Dabigatran-related Gastrointestinal Bleeding With Gastroprotective Agents: A Population-Based Study, Gastroenterology. 2015.
Hung I.F.N., Liu S.H.K., Tan V.P.Y., Hsu A.S.J., Seto W.K.W., Tong S.M. and Leung W.K., Seven-day Rifabutin Containing Triple Therapy Versus Seven-day Levofloxacin Containing Quadruple Therapy as Second-line Treatment for Helicobacter pylori in Chinese Patients: an Open Label, Randomized Trial, Digestive Disease Week 2015. (Oral presentation). 2015, S149.
LAU C.Y., Chan E.W., Wong I.C.K., HE Y., Tong S.M. and Leung W.K., Use of gastroprotective agents and risk of dabigatran associated gastrointestinal bleeding: a population-based retrospective cohort study, United European Gastroenterology (UEG) Week,18-22 October, Vienna. 2014.
Leung W.K., Tong D.K.H., Leung S.Y., Chan S.Y., Tong S.M., Ho R.S.L., Chu K.M. and Law S.Y.K., Treatment of gastric metaplasia or dysplasia by endoscopic radiofrequency ablation: A pilot study, Hepato-Gastroenterology. 2015, 62: 52-55.


Researcher : Tong SM
List of Research Outputs

Chan E.W., LAU C.Y., Leung W.K., Mok T.C., HE Y., Tong S.M. and Wong I.C.K., Effectiveness of gastroprotective agents on prevention of dabigatran related gastrointestinal bleeding: a population-based retrospective cobort study, 14th ISoP Annual Meeting "New Ideas in Ancient Cultures: Advancing Pharmacovigilance in Asia", 19-22 October 2014, Tianjin China. 2014.
Chan E.W., Lau C.Y., Leung W.K., Mok M.T.C., He Y., Tong S.M. and Wong I.C.K., Prevention of Dabigatran-related Gastrointestinal Bleeding With Gastroprotective Agents: A Population-Based Study, Gastroenterology. 2015.
Hung I.F.N., Liu S.H.K., Tan V.P.Y., Hsu A.S.J., Seto W.K.W., Tong S.M. and Leung W.K., Seven-day Rifabutin Containing Triple Therapy Versus Seven-day Levofloxacin Containing Quadruple Therapy as Second-line Treatment for Helicobacter pylori in Chinese Patients: an Open Label, Randomized Trial, Digestive Disease Week 2015. (Oral presentation). 2015, S149.
LAU C.Y., Chan E.W., Wong I.C.K., HE Y., Tong S.M. and Leung W.K., Use of gastroprotective agents and risk of dabigatran associated gastrointestinal bleeding: a population-based retrospective cohort study, United European Gastroenterology (UEG) Week,18-22 October, Vienna. 2014.
Leung W.K., Tong D.K.H., Leung S.Y., Chan S.Y., Tong S.M., Ho R.S.L., Chu K.M. and Law S.Y.K., Treatment of gastric metaplasia or dysplasia by endoscopic radiofrequency ablation: A pilot study, Hepato-Gastroenterology. 2015, 62: 52-55.


Researcher : Tse CTA
List of Research Outputs

Lee J.C.Y., Pang S.Y.Y., Tse C.T.A., Lau G.K.K., Chang S.K.R., Teo K.C. and Chan K.H., Thymomatous myasthenia gravis in Hong Kong Chinese, 20th Medical Research Conference, Department of Medicine, HKU. 2015.


Researcher : Tse EWC
Project Title:Outstanding Young Researcher Award 2009-10
Investigator(s):Tse EWC
Department:Medicine
Source(s) of Funding:Outstanding Young Researcher Award
Start Date:12/2010


Project Title:PIN1 and CKS proteins cooperate in the regulation of cell cycle progression
Investigator(s):Tse EWC
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:01/2013
Completion Date:12/2014


Project Title:Extending the therapeutic application of arsenic trioxide in acute myeloid leukaemia
Investigator(s):Tse EWC, Kwong YL
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:11/2013


List of Research Outputs

Chan S.Y.T., Hwang Y.Y.G., Singh G.H.H., Cheung C.W.S., Ting A.C.W., Beh S.L., Kwong Y.L. and Tse E.W.C., Increasing incidence of venous thromboembolism due to cancer-associated thrombosis in Hong Kong Chinese, Thrombosis Research. 2014.
Chen W.Y.W., Guo T., Shen L., Wong K.Y., Tao Q., Choi W.L., Au Yeung K.H.R., Chan Y.P., Wong M.L.Y., Tang J.C.O., Liu W.P., Li G.D., Shimizu N., Loong F., Tse E.W.C., Kwong Y.L. and Srivastava G., Receptor-type tyrosine-protein phosphatase k directly targets STAT3 activation for tumor suppression in nasal NK/T-cell lymphoma, Blood. United States of America, The American Society of Hematology, 2015, 125(10): 1589-600.
Chim J.C.S., Sim P.Y.J., Tam S., Tse E.W.C., Lie A.K.W. and Kwong Y.L., LDH is an adverse prognostic factor independent of ISS in transplant-eligible myeloma patients receiving bortezomib-based induction regimens, European Journal of Haematology. 2014, n/a-n/a.
Singh G.H.H., Chan T.S.Y., Hwang Y.Y.G., Leung A.Y.H., Tse E.W.C. and Kwong Y.L., Clofarabine And High-dose Cytarabine Arabinoside (clara) For Primary Refractory Or Relapsed Acute Myeloid Leukaemia – A Prospective Follow-up Study Of 60 Patients, 20th Congress of the European Haematology Association, Vienna, 11 - 15 June 2015.. 2015.
Singh G.H.H., Leung A.Y.H., Tse E.W.C. and Kwong Y.L., Relapse Characteristics And Risk Factors For Central Nervous System Involvement In Acute Promyelocytic Leukaemia In The Oral Arsenic Trioxide Era – A 13-year Follow-up Study, 20th Congress of the European Haematology Association, Vienna, June 11 - 15, 2015.. Haematologica, 2015.
Tse E.W.C., Chan S.Y.T., Koh L.P., Chng W.J., Kim W.S., Tang T., Lim S.T., Lie A.K.W. and Kwong Y.L., Allogeneic haematopoietic SCT for natural killer/T-cell lymphoma: a multicentre analysis from the Asia Lymphoma Study Group, Bone Marrow Transplantation. 2014, 49: 902-906.
Tse E.W.C. and Kwong Y.L., Epstein Barr virus-associated lymphoproliferative diseases: the virus as a therapeutic target, Experimental & Molecular Medicine. 2015, 47: e136.
Tse E.W.C. and Kwong Y.L., T-cell lymphoma: Microenvironment-related biomarkers, Seminars in Cancer Biology. 2015.


Researcher : Tse HF
Project Title:Direct intramyocardial implantation of autologous bone marrow cells for enhancement of neovascularization in patients with "End-Staged" coronary artery disease
Investigator(s):Tse HF, Lau CP, Kwong YL
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2004


Project Title:Outstanding Researcher Award 2007-2008
Investigator(s):Tse HF
Department:Medicine
Source(s) of Funding:Outstanding Researcher Award
Start Date:10/2008


Project Title:Direct endomyocardial injection of autologous bone marrow cells for treatment of patients with "end-stage" ischaemic heart failure
Investigator(s):Tse HF, Lau CP, Kwong YL, Siu DCW, Lee SWL, Chan HWF, Lam L, Lee KLF, Chan WS, Lam YM
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2009


Project Title:Personalized Medicine for Cardiovascular Diseases: From Genomic Testing and Biomarkers to Human Pluripotent Stem Cell Platform
Investigator(s):Tse HF, Xu A, Sham PC, Lam KSL, Lam TH, Cheung BMY, Tan KCB, Siu DCW, Lian Q, Cherny SS, Lam CW
Department:Medicine
Source(s) of Funding:Theme-based Research Scheme
Start Date:01/2012


Project Title:Mendelian randomization to causally infer the impact of life-long vitamin D deficiency on Cardiovascular disease and death: implications for community-based cardiovascular prevention
Investigator(s):Tse HF, Schooling CM, Cowling BJ, Sham PC, Lam TH, Chan YH
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:10/2012


Project Title:Targeted gene correction and disease modeling using Wilson's disease induced pluripotent stem cells
Investigator(s):Tse HF, Ho JCY
Department:Medicine
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2013


Project Title:Therapeutic Effects and Mechanism of Sympathorenal Axis Modulation by Catheter-based Renal Denervation in Porcine Model of Ischemic Heart Failure
Investigator(s):Tse HF
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2013


Project Title:Viral-Vector Integration-Free Human Induced Pluripotent Stem Cells Platform Derived from Urine Samples for Disease Diagnosis and Drug Screening
Investigator(s):Tse HF, Ho JCY, Lai KWH
Department:Medicine
Source(s) of Funding:Innovation and Technology Support Programme (Tier 3)
Start Date:07/2013
Completion Date:12/2014


Project Title:Effects of Catheter-based Splanchnic Denervation on Blood Pressure Control and Left Ventricular Remodeling in Porcine Model of Hypertensive Cardiomyopathy
Investigator(s):Tse HF
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2014


Project Title:Development of Wireless Powered Miniature Pacing Devices for Cardiac Rhythm Management
Investigator(s):Tse HF, Siu DCW, Lai KWH
Department:Medicine
Source(s) of Funding:Innovation and Technology Support Programme (Tier 3)
Start Date:12/2014


Project Title:Lower Thoracic Spinal Cord Stimulation for Treatment of Heart Failure with Preserved Ejection Fraction: Insight from a Porcine Model of Hypertensive Cardiomyopathy
Investigator(s):Tse HF
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2015


List of Research Outputs

Bao X., Wu H., Zhu X., Guo X., Hutchins A.P., Luo Z., Song H., CHEN Y., Lai K.W.H., Yin M., Xu L., Zhou L., Chen J., Wang D., Qin B., Frampton J., Tse H.F., Pei D., Wang H. and Zhang B., The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters., Cell Res. 2015. 2015, 25(1): 80-92.
CHENG Y., Tse H.F. and Rong J., Gallic acid-L-leucine conjugate corrects lipid mediator profiles in LPS-stimulated RAW264.7 via suppressing arachidonic acid metabolism, 2014 The 10th International Postgraduate Symposium on Chinese Medicine, Hong Kong Convention and Exhibition Center, Hong Kong, August 15, 2014.
CHENG Y., YANG C., ZHAO J., Tse H.F. and Rong J., Proteomic identification of calcium-binding chaperone calreticulin as a potential mediator for the neuroprotective and neuritogenic activities of botanical drug amygdalin,, 13th Meeting of Consortium for Globalization of Chinese Medicine (CGCM), Beijing, August 27 - 29, 2014.
CHENG Y., YANG C., ZHAO J., Tse H.F. and Rong J., Proteomic identification of calcium-binding chaperone calreticulin as a potential mediator for the neuroprotective and neuritogenic activities of fruit-derived glycoside amygdalin, Journal of Nutritional Biochemistry. 2014, 26: 146-54.
Chan P.H.M. and Tse H.F., Adoption of Cardiac Resynchronization Therapy in Heart Failure Patients with Post-Cardiac Valve Surgery or Interventions?, Journal of Cardiovascular Electrophysiology. 2014, n/a-n/a.
Chan P.H.M., Li W., Hai S.H.J.J., Tse H.F. and Siu D.C.W., Impact of Antithrombotic Therapy in Atrial Fibrillation on the Presentation of Coronary Artery Disease, PLOS ONE. 2015, 10: e0131479.
Chan Y.H., Yiu K.H., Lau G.K.K., Yiu Y.F., Li S.W., Lam T.H., Lau C.P., Siu C.W. and Tse H.F., The CHADS2 and CHA2DS2-VASc scores predict adverse vascular function, ischemic stroke and cardiovascular death in high-risk patients without atrial fibrillation: Role of incorporating PR prolongation, Atherosclerosis. 2014, 237(2): 504-13.
Chan Y.H., Lau K.K., Yiu K.H., Li L.S.W., Tam S., Lam T.H., Lau C.P., Siu D.C.W., Cheung B.M.Y. and Tse H.F., Vascular protective effects of statin-related increase in serum 25-hydroxyvitamin D among high-risk cardiac patients, Journal of Cardiovascular Medicine. 2015, 16: 51-58.
Chan Y.H., Lau G.K.K., Yiu K.H., Li L.S.W., Tam S., Lam T.H., Lau C.P., Siu D.C.W., Cheung B.M.Y. and Tse H.F., Vascular protective effects of statin-related increase in serum 25-hydroxyvitamin D among high-risk cardiac patients, Journal of Cardiovascular Medicine (Hagerstown). 2015.
Chen Y., Chung H.Y., Zhao C.T., Wong A., Zhen S., Tsang H.H., Lau W.C.S., Tse H.F. and Yiu K.H., Left ventricular myocardial dysfunction and premature atherosclerosis in patients with axial spondyloarthritis, Rheumatology. 2015, 54: 292-301.
Cheung Y.Y., Hui Y.L.E., Cheung B.M.Y., Woo Y.C., Xu A., Fong H.Y., Ong K.L., Yeung C.Y., Janus E.D., Tse H.F., Sham P.C. and Lam K.S.L., Adiponectin gene variants and the risk of coronary heart disease: a 16-year longitudinal study., Eur J Endocrinol. 2014, 171: 107-115.
Dong J.Z., Sang C.H., Yu R.H., Long Y., Tang R.B., Jiang C.X., Ning M., Liu N., Liu X.P., Du X., Tse H.F. and Ma C.S., Prospective randomized comparison between a fixed '2C3L' approach vs. stepwise approach for catheter ablation of persistent atrial fibrillation., Europace. 2015. 2015, 1: 1.
Hai J.J., Singh G.H.H., Tse H.F., Kumana C.R., Kwong Y.L. and Siu D.C.W., Torsade de Pointes during oral arsenic trioxide therapy for acute promyelocytic leukemia in a patient with heart failure, Annals of Hematology. 2014.
Hai S.H.J.J., Chan P.H.M., Tse H.F. and Siu D.C.W., Slow Heart Rate Predicts New Occurrence of Atrial Fibrillation, Heart, Lung and Circulation. 2015.
Ho C.W., Ho M.H., Chan P.H.M., Hai S.H.J.J., Cheung E., Yeung C.Y., Lau G.K.K., Chan K.H., Lau C.P., Lip G.Y., Leung G.K.K., Tse H.F. and Siu D.C.W., Ischemic stroke and intracranial hemorrhage with aspirin, dabigatran, and warfarin: impact of quality of anticoagulation control, Stroke. 2015.
Ho M.H., Ho C.W., Cheung E., Chan P.H.M., Hai J.J., Chan K.H., Chan E.W., Leung G.K.K., Tse H.F. and Siu D.C.W., Continuation of Dabigatran Therapy in “Real-World” Practice in Hong Kong, PLoS ONE. 2014, 9(8): e101245.
Hu X., Huang X., Yang Q., Wang L., Sun J., Zhan H., Lin J., Pu Z., Jiang J., Sun Y., Xiang M., Liu X., Xie X., Yu X., Chen Z., Tse H.F., Zhang J. and Wang J., Safety and efficacy of intracoronary hypoxia-preconditioned bone marrow mononuclear cell administration for acute myocardial infarction patients: The CHINA-AMI randomized controlled trial., Int J Cardiol. 2015. 2015, 1.
Huang D., Anguo L., Yue W.S., Yin L., Tse H.F. and Siu D.C.W., Refinement of Ischemic Stroke Risk in Patients with Atrial Fibrillation and CHA2 DS2 -VASc Score of 1., Pacing Clin Electrophysiol. 2014 Jul 16. 2014.
Hui Y.L.E., Xu A., Chow W.S., Lee P.C.H., Fong H.Y., Cheung C.W.S., Tse H.F., Chau M.T., Cheung B.M.Y. and Lam K.S.L., Hypoadiponectinemia As an Independent Predictor for the Progression of Carotid Atherosclerosis: A 5-Year Prospective Study, Metabolic Syndrome and Related Disorders. 2014, 12: 517-522.
LIANG Y., LI X., Zhang Y., ZHEN Z., Yeung S.C., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Amelioration of cigarette smoke-induced cardiac dysfunction and inflammation by mesenchymal stem cells, J HK Coll Cardiol. 2014, 22: 49.
LIANG Y., LI X., Zhang Y., ZHEN Z., Yeung S.C., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Outstanding Oral presentation - Amelioration of cigarette smoke-induced cardiac dysfunction and inflammation by mesenchymal stem cells , 18th Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine. 2014.
Lee Y.K., Ran X., Lai K.W.H., Lau V.Y.M., Siu D.C.W. and Tse H.F., Generation and Characterization of Patient-SpecificInduced Pluripotent Stem Cell Model for Cardiovascular Disease, Springer Protocols. 2015.
Lee Y.K., Ng K.M. and Tse H.F., Modeling of Human Cardiomyopathy with Induced Pluripotent Stem Cells, Journal of Biomedical Nanotechnology. 2014, 10: 2562-2585.
Li W.C. and Tse H.F., Health Risk and significance of mercury in the environment, Eviron Sci Pollut Res Int. 2015, 22(1): 192-201.
Li X., Zhang Y., Yeung S.C., Liang Y., Li X., Ding Y., Ip M.S.M., Tse H.F., Mak J.C.W. and Lian Q., Mitochondrial transfer of induced pluripotent stem cells-derived MSCs to airway epithelial cells attenuates cigarette smoke-induced damage, American Journal of Respiratory Cell and Molecular Biology. 2014, 51(3): 455-465.
Liang X., Ding Y., Zhang Y., Chai Y.H., He J., Chiu S., GAO F., Tse H.F. and Lian Q., Activation of NRG1-ERBB4 signaling potentiates mesenchymal stem cell-mediated myocardial repairs following myocardial infarction, Cell Death and Disease. 2015, 6: e1765.
Liao S., Liu Y., Zhang Y., Au K.W., Lai K.W.H., Siu D.C.W. and Tse H.F., Remodelling of cardiac sympathetic re-innervation with thoracic spinal cord stimulation improves left ventricular function in a porcine model of heart failure., Europace. 2015, 2105 MAR 12: 409.
Liu L., Xu Y., He M., Zhang M., Cui F., Lu L., Yao M., Tian W., Benda C., Zhuang Q., Huang Z., Li W., Li X., Zhao P., Fan W., Luo Z., Li Y., Wu Y., Hutchins A.P., Wang D., Tse H.F., Schambach A., Frampton J., Qin B., Bao X., Yao H., Zhang B., Sun H., Pei D., Wang H., Wang J. and Esteban M.A., Transcriptional pause release is a rate-limiting step for somatic cell reprogramming., Cell Stem Cell. . 2014, 15(5): 574-588.
NG A.K.Y., Ng K.M., Tse H.F., Lai K.W.H., CHAN W.S., Siu D.C.W. and Fan K., Pseudo-Pre-Excitation Unraveled Down to Its Core, Circulation. 2014, 130: e56-e58.
Ng K.M., LAW C.Y. and Tse H.F., Clinical Potentials of Cardiomyocytes Derived from Patient-Specific Induced Pluripotent Stem Cells, In: Prof. Jane Grant-Kels, Journal of Clinical Medicine. MDPI AG, Basel, Switzerland, 2014, 3: 1105-1123.
Poon M.W., Yan L., Jiang D., Qin P., Tse H.F., Wong Y.H.I., Wong D.S.H., Tergaonkar V. and Lian Q., Inhibition of RAP1 enhances corneal recovery following alkali injury, Investigative Ophthalmology and Visual Science. 2015, 56(2): 711-721.
Santoso T., Siu D.C.W., Irawan C., Chan W.S., Alwi I., Yiu K.H., Aziz A., Kwong Y.L. and Tse H.F., Endomyocardial Implantation of Autologous Bone Marrow Mononuclear Cells in Advanced Ischemic Heart Failure: a Randomized Placebo-Controlled Trial (END-HF)., J Cardiovasc Transl Res. 2014.
Shenthar J., Milasinovic G., Al Fagih A., Gotte M., Engel G., Wolff S., Tse H.F., Herr J., Carrithers J., Cerkvenik J. and Nahle C.P., MRI scanning in patients with new and existing CapSureFix Novus 5076 pacemaker leads: randomized trial results. ., Heart Rhythm. 2015. 2015, Apr:12(4): 759-765.
Tse H.F., Asia Pacific Stroke Prevention in Atrial Fibrillation (SPAF) Expert Forum, Taipei, Taiwan “ Clinical perspectives: Challenging cases in AF management – use of VKAs and/or aspirin and decision-making” , 2014.
Tse H.F., European Society of Cardiology Congress 2014, Barcelona, Spain, “Remodeling of cardiac sympathetic innervation with thoracic spinal cord simulation improves left ventricular function in a porcine model of ischemic cardiomyopathy”, 2014.
Tse H.F., Invited Speaker, 29th Annual Meeting of the Japanese Heart Rhythm Society, Tokyo “Subcutaneous ICD:Protection without Touching the Heart”, 2014.
Tse H.F., Invited Speaker, AFNET and EHRA meeting, European Heart House, Sophia Antipolis France, “ Prevention of AF related complication: Asian-Pacific Perspective”, 2015.
Tse H.F., Invited Speaker, Asia Pacific Stroke Prevention in Atrial Fibrilaltion (SPAF) Expert Forum, Taipei, Taiwan “ Clinical perspectives:Challenging cases in AF management – use of VKAs and/or aspirin and decision-making”, 2014.
Tse H.F., Invited Speaker, Asia Pacific Stroke Conference, Taipei, Taiwan,” WS5 Genetic Translational Workshop, 2014.
Tse H.F., Invited Speaker, China International Cardiac Pacing Summit, Haikou, China, “ Thoracic Spinal Cord Stimulation for Heart Failure as a restorative Treatment (SCS Heart Study”, 2015.
Tse H.F., Invited Speaker, Chinese Heart Rhythm Society Annual Sessions, Beijing, China “Indication and Implantation Techniques of Subcutaneous ICD”, 2015.
Tse H.F., Invited Speaker, EHRA Europace- CARDIOSTIM 2015, Milan, Italy “ Device Mangement using remote monitoring”, 2015.
Tse H.F., Invited Speaker, European Society of Cardiology Congress 2014, Barcelona, Spain, “Remodeling of cardiac sympathetic innervation with thoracic spinal cord simulation improves left ventricular function in a porcine model of ischemic cardiomyopathy” , 2014.
Tse H.F., Invited Speaker, Heart Rhythm Society, US, “ Spinal Cord Stimulation for Heart Failure and Ventricular Arrhythmias in a Joint Session Entitled Advances in Device Therapy”, 2015.
Tse H.F., Invited Speaker, INS 12th Congress, Canada, “Spinal Cord Stimulation to treat Heart Failure”, 2015.
Tse H.F., Invited Speaker, Interactions Summit in SPAF across Mainland Chinam Bejing, “ NOAC in Asian Patient,”, 2015.
Tse H.F., Invited Speaker, Macau Cardiology Meeting, Macau, “Cardio-protection of beta-blockers along CV continuum”, 2015.
Tse H.F., Invited Speaker, Macau Physician Assocation fo Public Hospital, Macau “ Lifetime Benefit of Lower LDL- C:Evidence from CV outcome Trials, 2015.
Tse H.F., Invited Speaker, Stroke Prevention in AF Masterclass in Asia, Taiwan “ Stroke Prevention in non-valvular AF in the real world, 2015.
Tse H.F., Invited Speaker, The 16th International Symposium on Hypertension & related disease, Shanghai, China,” Visit-to-visit blood pressure variability and cardiovascular outcomes in hypertensive patients” , 2014.
Tse H.F., Invited Speaker,Asia Novartis Biomedical Symposium, Taipei, Taiwan, “ Patients Specific Indcued Plurioptent Stem Cell Derived In-vitro and in-vivo Drug Screening, 2015.
Tse H.F., Invited Speaker,Phyathai Cardiac Symposium, Bangkok, Thailand “ Trouble Shooting in NOACs Related coagulopathy and bleeding “ Current knowledge in NOACS and the introudciton to the upcoming reserachers”, 2015.
Tse H.F., Turner S., Sanders P., Okuyama Y., Fujiu K., Cheng C.W., Russo M., Green M.D., Yiu K.H., Chen P., Shunto C., Lau E.O. and Siu D.C.W., Thoracic Spinal Cord Stimulation for Heart Failure as a Restorative Treatment (SCS HEART study): first-in-man experience, Heart Rhythm. 2015, 12(3): 588-595.
Tse H.F., World Heart Day Public talk Hong Kong College of Cardiology 三高治療，全方位攻略 , 2014.
WONG C.K.A., CHEN Y., HO L.M., ZHEN Z., Siu D.C.W., Tse H.F. and Yiu K.H., Angiographic result of T-stenting with small protrusion using drug-eluting stents in the management of ischemic side branch: the ARTEMIS study., Nutr Metab Cardiovasc Disorder 2014. 2014.
Wu Y., Li Y., Zhang H., Huang Y., Zhao P., Tang Y., Qiu X., Ying L., Li W., Ni S., Zhang M., Liu L., Xu Y., Zhuang Q., Luo Z., Benda C., Song H., Liu B., Lai L., Liu X., Tse H.F., Bao X., Chan W.Y., Esteban M.A., Qin B. and Pei D., 10. Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming., Nat Cell Biol. 2015, 17(6): 715-725.
XU J., Lee Y.K., Wang Y. and Tse H.F., Therapeutic Application of Endothelial Progenitor Cells for Treatment of Cardiovascular Diseases, Current Stem Cell Research & Therapy. 2014, 401-414 (14).
Yiu K.H., Ng W.S., Chan D., Sit K.Y., Wong A., Lee C.W., Chum H.L., Cheung W.Y., Pun C.T., Ho K.L., CHEN Y., Ho K.M., Kumana C.R., Cheung H.L., Chung M.C., Lau C.P., Au K.W. and Tse H.F., Improved prognosis following renin-angiotensin-aldosterone system blockade in patients undergoing concomitant aortic and mitral valve replacement., Int J Cardiol. 2014. 2014, 177(2): 680-682.
Zhang Y., LIANG X., Liao S., Wang W., Wang J.J., LI X., Ding Y., LIANG Y., GAO F., Yang M., Fu Q., Xu A., Chai Y.H., He J., Tse H.F. and Lian Q., Potent Paracrine Effects of human induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Attenuate Doxorubicin-induced Cardiomyopathy, Scientific Reports. 2015, 5: 11235.


Researcher : Tse HM
List of Research Outputs

Ho W.L., Pang S.Y.Y., Li M., Tse H.M., Kung M.H.W., Sham P.C. and Ho S.L., PMCA4 (ATP2B4) mutation in familial spastic paraplegia causes delay in intracellular calcium extrusion, Brain and Behavior. 2015, 5: n/a-n/a.
Li M., Ho W.L., Pang S.Y.Y., Tse H.M., Kung M.H.W., Sham P.C. and Ho S.L., PMCA4 (ATP2B4) Mutation in Familial Spastic Paraplegia, PLoS ONE. 2014.


Researcher : Tse WW
List of Research Outputs

Chan D.T.M., Au K.Y., MA X., Tse W.W., Chau K.M. and Yung S.S.Y., CD44 expression in serum and kidney correlates with disease activity in lupus nephritis, 52nd European Renal Association/European Dialysis Transplantation Association Congress. 2015.
Chan D.T.M., Tse W.W., Chau K.M. and Yung S.S.Y., Increased Synthesis of CD44s and its Variants in Kidney Fibrosis of Lupus Nephritis, American Society of Nephrology Kidney Week 2014.
Chan D.T.M., Au K.Y., MA X., Tse W.W., Chau K.M. and Yung S.S.Y., Serum and renal expression of CD44s and its variants correlate with disease activity in lupus nephritis, World Congress of Nephrology 2015.
Yung S.S.Y., Tse W.W., Chau K.M. and Chan D.T.M., Inhibition of Hyaluronan Synthesis in NZBWF1/J Mice Decreased Glomerular Deposition of Fibronectin and Collagen and Improved Renal Function, Gordon Research Conference Fibronectin, Integrins & Related Molecules. 2015.


Researcher : Tso AWK
Project Title:A population-based prospective study to investigate the associations of obesity and adipokines with the incidence of cardiovascular disease and cancer
Investigator(s):Tso AWK, Cheung BMY, Lam KSL, Lam TH, Tse HF, Wat NMS
Department:Medicine
Source(s) of Funding:Health and Health Services Research Fund - Full Grants
Start Date:12/2008


Project Title:Adipocyte fatty acid-binding protein – an adipocytokine with a role in diabetic nephropathy ?
Investigator(s):Tso AWK, Lam KSL, Chan DTM, Xu A
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2009


List of Research Outputs

Woo Y.C., Cheung B.M.Y., Yeung C.Y., Lee C.H.P., Hui Y.L.E., Fong H.Y., Tso A.W.K., Tam S. and Lam K.S.L., Cardiometabolic risk profile of participants with prediabetes diagnosed by HbA1c criteria in an urban Hong Kong Chinese population over 40 years of age , Diabetic Medicine. 2015, n/a-n/a.


Researcher : Tsui MSH
List of Research Outputs

Man K.C.K., Chan E.W., Coghill D., Douglas I., Ip P., Leung L.P., Tsui M.S.H., Wong W.H.S. and Wong I.C.K., Methylphenidate and the Risk of Trauma, PEDIATRICS. 2014, 135(1): 40-48.


Researcher : WANG B
List of Research Outputs

WANG B., Cheng K.Y., Li X., Lam K.S.L. and Xu A., Hypothalamic APPL2 combats against obesity by promoting adaptive thermogenesis in white adipose tissues, EMBL Symposium: Translating Diabetes.. 2015.
WANG B., Cheng K.Y., Li X., Li A., Lam K.S.L. and Xu A., The Role of Hypothalamic APPL2 in Regulation of Energy Expenditure in Adipose Tissues, 2015 Asia Pacific obesity and diabetes symposium.. 2015.
WANG B., Cheng K.Y., Li X., Li A., Lam K.S.L. and Xu A., The hypothalamic APPL2 as a novel regulator of energy homeostasis in adipose tissues, The 10th International Symposium on Healthy Aging 2015. A Decade of Positive Aging. 2015.. 2015.


Researcher : WANG L
List of Research Outputs

WANG L. and Chim J.C.S., DNA methylation of tumor suppressor miRNAs genes in chronic lymphocytic leukemia, Epigenomics. 2015, 7(3): 461-473.


Researcher : WANG Y
List of Research Outputs

WANG Y., Xiao Y., ZHONG L., Ye D., Zhang J., Tu Y., Bornstein S.R., Zhou Z., Lam K.S.L. and Xu A., Increased Neutrophil Elastase and Proteinase 3 and Augmented NETosis Are Closely Associated With  -Cell Autoimmunity in Patients With Type 1 Diabetes, Diabetes. 2014, 63: 4239-4248.
WANG Y., Yeung S.C., Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Intermittent hypoxia accelerates adipogenic differentiation in human subcutaneous preadipocytes in vitro, Am J Respir Crit Care Med. 2015, 191: A2704.
Wong C.M., WANG Y., LEE T.H.J., HUANG Z., Wu D., Xu A. and Lam K.S.L., Adropin is a brain membrane-bound protein regulating physical activity via NB-3/Notch signaling pathway in mice, The Journal of Biological Chemistry. 2014.
XU J., Lee Y.K., Wang Y. and Tse H.F., Therapeutic Application of Endothelial Progenitor Cells for Treatment of Cardiovascular Diseases, Current Stem Cell Research & Therapy. 2014, 401-414 (14).
Ye D., Wang Y., Li H., Jia W., Man K., Lo C.M., Wang Y., Lam K.S.L. and Xu A., Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1α-mediated antioxidant capacity in mice, Hepatology. 2014, 60: 977-989.


Researcher : WANG Y
List of Research Outputs

WANG Y., Xiao Y., ZHONG L., Ye D., Zhang J., Tu Y., Bornstein S.R., Zhou Z., Lam K.S.L. and Xu A., Increased Neutrophil Elastase and Proteinase 3 and Augmented NETosis Are Closely Associated With  -Cell Autoimmunity in Patients With Type 1 Diabetes, Diabetes. 2014, 63: 4239-4248.
WANG Y., Yeung S.C., Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Intermittent hypoxia accelerates adipogenic differentiation in human subcutaneous preadipocytes in vitro, Am J Respir Crit Care Med. 2015, 191: A2704.
Wong C.M., WANG Y., LEE T.H.J., HUANG Z., Wu D., Xu A. and Lam K.S.L., Adropin is a brain membrane-bound protein regulating physical activity via NB-3/Notch signaling pathway in mice, The Journal of Biological Chemistry. 2014.
XU J., Lee Y.K., Wang Y. and Tse H.F., Therapeutic Application of Endothelial Progenitor Cells for Treatment of Cardiovascular Diseases, Current Stem Cell Research & Therapy. 2014, 401-414 (14).
Ye D., Wang Y., Li H., Jia W., Man K., Lo C.M., Wang Y., Lam K.S.L. and Xu A., Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1α-mediated antioxidant capacity in mice, Hepatology. 2014, 60: 977-989.


Researcher : WONG CKA
List of Research Outputs

WONG C.K.A., CHEN Y., HO L.M., ZHEN Z., Siu D.C.W., Tse H.F. and Yiu K.H., Angiographic result of T-stenting with small protrusion using drug-eluting stents in the management of ischemic side branch: the ARTEMIS study., Nutr Metab Cardiovasc Disorder 2014. 2014.


Researcher : WONG WLD
List of Research Outputs

LI R., Yiu W.H., Wu H., LIN M., WONG W.L.D., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., BMP7 Reduces Tubular Inflammation and Oxidative Stress in Diabetic Nephropathy, J Am Soc Nephrol. 2014, 25: 216A.
LI R., Yiu W.H., Wu H., WONG W.L.D., Chan Y.Y., LIN M., Leung J.C.K., Lai K.N. and Tang S.C.W., BMP7 reduces inflammation and oxidative stress in diabetic tubulopathy, Clinical Science [IF 5.629]. 2015, 128(4): 269-280.
Yiu W.H., WONG W.L.D., Leung J.C.K., Chan Y.Y., Lai K.N. and Tang S.C.W., Thrombin Induces Epithelial-Mesenchymal Transition Through the Activation of PAR-1 in Tubular Epithelial Cells, J Am Soc Nephrol. 2014, 25: 730A.


Researcher : WU H
List of Research Outputs

LI R., Yiu W.H., Wu H., LIN M., WONG W.L.D., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., BMP7 Reduces Tubular Inflammation and Oxidative Stress in Diabetic Nephropathy, J Am Soc Nephrol. 2014, 25: 216A.
LI R., Yiu W.H., Wu H., WONG W.L.D., Chan Y.Y., LIN M., Leung J.C.K., Lai K.N. and Tang S.C.W., BMP7 reduces inflammation and oxidative stress in diabetic tubulopathy, Clinical Science [IF 5.629]. 2015, 128(4): 269-280.
WU H., Lo Y., LUK T.W., Lau C.S., Lu L.W. and Mok T.M.Y., Alternatively activated dendritic cells derived from systemic lupus erythematosus patients have tolerogenic phenotype and function.European League of Association of Rheumatology (EULAR) 2015 Annals of the Rheumatic Diseases 2015; 74(Suppl2), 2015, 74(Suppl2): 951.
WU H., Lo Y., Luk D., Lau W.C.S., Lu L. and Mok T.M.Y., Alternatively activated dendritic cells derived from systemic lupus erythematosus patients have tolerogenic phenotype and function, Clinical Immunology. 2015, 156: 43-57.
WU H., Lo Y., LUK T.W., Lau C.S., Lu L. and Mok T.M.Y., Alternatively activated dendritic cells derived from systemic lupus erythematosus patients have tolerogenic phenotype and function, Hong Kong Medical Journal 2015;21:p55 (Abstract 90) . 2015.
WU H., Lo Y., LUK T.W., Chan W.K. and Mok T.M.Y., Bone marrow derived dendritic cells modified by lentiviral-mediated RelB shRNA possess tolerogenic phenotype and functions on lupus splenic lymphocytes. European League of Association of Rheumatology (EULAR) 2015. Ann Rheum Dis 2015; 74(Suppl2), 2015, 74(Suppl2): 951.
WU H. and Mok T.M.Y., The generation and therapeutic application of tolerogenic dendritic cells in systemic lupus erythematosus, PhD thesis. 2014.


Researcher : WU X
List of Research Outputs

SHU L., WU X., CHEONG L.Y., Zhou M., Lam K.S.L., Xu A. and Hoo R.L.C., Adipocyte fatty acid binding protein (A-FABP) is a potential regulator of adaptive thermogenesis, Tenth international symposium on healthy aging"A decade of positive aging ". 2015.


Researcher : Wang AYM
Project Title:An epidemiologic survey of vitamin D deficiency in Chinese patients with moderate to severe chronic kidney disease
Investigator(s):Wang AYM, Kwan CW, Lai KN
Department:Medicine
Source(s) of Funding:Health and Health Services Research Fund - Full Grants
Start Date:07/2008


Project Title:Providing intravenous paricalcitol treatment to the sick and poor chronic hemodialysis patients with severe secondary hyperparathyroidism resistant to existing vitamin D analogs
Investigator(s):Wang AYM
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:08/2010




Researcher : Wang J
Project Title:Characterization of the interaction between XAF1 and FHL2 in carcinogenesis and differentiation of gastrointestinal cancers
Investigator(s):Wang J, Wong BCY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2008


Project Title:Elucidation of the role of Sp1 in maintaining the survival and renewal of colon cancer stem cells
Investigator(s):Wang J, Wong BCY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2009




Researcher : Wang J.
Project Title:Characterization of the interaction between XAF1 and FHL2 in carcinogenesis and differentiation of gastrointestinal cancers
Investigator(s):Wang J, Wong BCY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2008


Project Title:Elucidation of the role of Sp1 in maintaining the survival and renewal of colon cancer stem cells
Investigator(s):Wang J, Wong BCY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2009




Researcher : Wang Y
List of Research Outputs

WANG Y., Xiao Y., ZHONG L., Ye D., Zhang J., Tu Y., Bornstein S.R., Zhou Z., Lam K.S.L. and Xu A., Increased Neutrophil Elastase and Proteinase 3 and Augmented NETosis Are Closely Associated With  -Cell Autoimmunity in Patients With Type 1 Diabetes, Diabetes. 2014, 63: 4239-4248.
WANG Y., Yeung S.C., Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Intermittent hypoxia accelerates adipogenic differentiation in human subcutaneous preadipocytes in vitro, Am J Respir Crit Care Med. 2015, 191: A2704.
Wong C.M., WANG Y., LEE T.H.J., HUANG Z., Wu D., Xu A. and Lam K.S.L., Adropin is a brain membrane-bound protein regulating physical activity via NB-3/Notch signaling pathway in mice, The Journal of Biological Chemistry. 2014.
XU J., Lee Y.K., Wang Y. and Tse H.F., Therapeutic Application of Endothelial Progenitor Cells for Treatment of Cardiovascular Diseases, Current Stem Cell Research & Therapy. 2014, 401-414 (14).
Ye D., Wang Y., Li H., Jia W., Man K., Lo C.M., Wang Y., Lam K.S.L. and Xu A., Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1α-mediated antioxidant capacity in mice, Hepatology. 2014, 60: 977-989.


Researcher : Wang Y
List of Research Outputs

WANG Y., Xiao Y., ZHONG L., Ye D., Zhang J., Tu Y., Bornstein S.R., Zhou Z., Lam K.S.L. and Xu A., Increased Neutrophil Elastase and Proteinase 3 and Augmented NETosis Are Closely Associated With  -Cell Autoimmunity in Patients With Type 1 Diabetes, Diabetes. 2014, 63: 4239-4248.
WANG Y., Yeung S.C., Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Intermittent hypoxia accelerates adipogenic differentiation in human subcutaneous preadipocytes in vitro, Am J Respir Crit Care Med. 2015, 191: A2704.
Wong C.M., WANG Y., LEE T.H.J., HUANG Z., Wu D., Xu A. and Lam K.S.L., Adropin is a brain membrane-bound protein regulating physical activity via NB-3/Notch signaling pathway in mice, The Journal of Biological Chemistry. 2014.
XU J., Lee Y.K., Wang Y. and Tse H.F., Therapeutic Application of Endothelial Progenitor Cells for Treatment of Cardiovascular Diseases, Current Stem Cell Research & Therapy. 2014, 401-414 (14).
Ye D., Wang Y., Li H., Jia W., Man K., Lo C.M., Wang Y., Lam K.S.L. and Xu A., Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1α-mediated antioxidant capacity in mice, Hepatology. 2014, 60: 977-989.


Researcher : Wong B.C.Y.
Project Title:Effect of XAF1 gene on tumor growth in gastric and colon cancer
Investigator(s):Wong BCY, Tu S
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2003


Project Title:Role of Bcl-2 family proteins in non-steroidal anti-inflammatory drug-induced apoptosis of gastric cancer
Investigator(s):Wong BCY, Xia HHX
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2004


List of Research Outputs



Researcher : Wong BCY
Project Title:Effect of XAF1 gene on tumor growth in gastric and colon cancer
Investigator(s):Wong BCY, Tu S
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2003


Project Title:Role of Bcl-2 family proteins in non-steroidal anti-inflammatory drug-induced apoptosis of gastric cancer
Investigator(s):Wong BCY, Xia HHX
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2004


List of Research Outputs

Tan V.P.Y., Wong B.C.Y., Wong R.W.M., Leung W.K., Tong D.K.H., Yuen R.M.F. and Fass R., Gastroesophageal reflux disease: cross-sectional study demonstrating rising prevalence in a Chinese population, J Clin Gastroenterol. 2015, Epub ahead of print.


Researcher : Wong CF
List of Research Outputs

Wong C.F., Lau G.K.K. and Fung S.L., Endobronchial tuberculosis: Always a diagnostic challenge, QJM. 2015.


Researcher : Wong CM
Project Title:Coupling of nuclear RNA surveillance with splicing
Investigator(s):Wong CM, Chen C
Department:Medicine
Source(s) of Funding:National Natural Science Foundation of China (NSFC) - General Program
Start Date:01/2013


Project Title:Deciphering the role of lipocalin 13 in obesity and diabetes: from molecular analysis to physiological relevance
Investigator(s):Wong CM, Xu A
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2013


Project Title:To study the role of mouse G-protein couple receptor GPR110 in the pathogenesis of obesity related medical complication
Investigator(s):Wong CM
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2014


Project Title:Deciphering the role of the long noncoding RNA Maternally Expressed 3 (MEG3) in hepatic lipid metabolism
Investigator(s):Wong CM
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2015


List of Research Outputs

Lam K.S.L., Chan Y.C.C., Stillitano A., Wong C.M., Pang Y. and Xu A., Adipose tissue FGF21 resistance contributes to hypoadiponectinemia and insulin resistance in obesity: Role of miR-34a, The 75th Scientific Sessions of the American Diabetes Association, 5-9 Jun 2015, Boston, USA. 2015.
Pan K., LEE T.H.J., HUANG Z. and Wong C.M., Coupling and Coordination in Gene Expression Processes with Pre-mRNA Splicing, International Journal of Molecular Sciences. 2015, 16(3): 5682-5696.
Tang H.M., Pan K., Kong K.Y.E., Hu L., Chan L.C., Siu K.L., Sun H., Wong C.M. and Jin D., Loss of APD1 in Yeast Confers Hydroxyurea Sensitivity Suppressed by Yap1p Transcription Factor, Scientific Reports. 2015, 5: 7897.
Wong C.M., WANG Y., LEE T.H.J., HUANG Z., Wu D., Xu A. and Lam K.S.L., Adropin is a brain membrane-bound protein regulating physical activity via NB-3/Notch signaling pathway in mice, The Journal of Biological Chemistry. 2014.
Wong C.M., Pan K., HUANG Z. and LEE T.H.J., Current perspectives on the role of TRAMP in nuclear RNA surveillance and quality control, Research and Reports in Biochemistry. 2015, 5: 111-117.


Researcher : Wong DKH
Project Title:Mutational analysis of the hepatitis B core protein DNA-binding domain and its role in HBV transcription regulation
Investigator(s):Wong DKH, Huang FY, Lai CL, Yuen RMF
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2013


Project Title:Hepatitis B X protein primary structure and epigenetic regulation of HBV replication
Investigator(s):Wong DKH, Huang FY, Seto WKW, Fung JYY, Lai CL, Yuen RMF
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:03/2014


List of Research Outputs

Fung J.Y.Y., Wong D.K.H., Seto W.K.W., Kopaniszen M., Lai C.L. and Yuen R.M.F., Hepatitis B Surface Antigen Seroclearance: Relationship to Hepatitis B e-Antigen Seroclearance and Hepatitis B e-Antigen-Negative Hepatitis, The American Journal of Gastroenterology. 2014, 109: 1764-1770.
Huang F.Y., Wong D.K.H., Seto W.K.W., Lai C.L. and Yuen R.M.F., Estradiol activated microrna 23a directly or synergistically with p53 implicated in sex difference in hepatocellular carcinoma development, 24th Annual Conference of APASL, March 12–15, 2015, Istanbul, Turkey. Hepatology International. 2015, 9 (Suppl 1): S137-8.
Hung I.F.N., Wong D.K.H., Poon R.T.P., Fong D.Y.T., Seto W.K.W., Fung J.Y.Y., Yuen J.C.H., Tiu T.M.R.J., Lai C.L. and Yuen R.M.F., Risk Factors and Post-resection Independent Predictive Score for the Recurrence of Hepatitis B-related Hepatocellular Carcinoma, 20th Medical Research Conference 2015, 17 Jan 2015, The University of Hong Kong, Hong Kong.. 2015.
Lai C.L., Wong D.K.H., Ip P.C.P., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lee B.P., Cullaro G., Wu C.H., Cheng C.T.K., Yuen J.C.H., Ngai W.S. and Yuen R.M.F., Profound Reduction of HBV Covalently Closed Circular DNA with Long-term Nucleoside/tide Analogue Therapy, Hepatology. 2014, 60, No. 4 (Suppl): 183A.
Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Liu S.H.K., Singh G.H.H., Lam Y.F., Fung J.Y.Y., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., A prospective study of hepatitis B reactivation in patients with prior HBV exposure undergoing hematopoietic stem cell transplantation: Reactivation association with graft-versus-host disease, Oral presentation at the International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2015, 62(Suppl 2): S194.
Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Hepatitis B reactivation in patients with prior HBV exposure undergoing rituximab-containing chemotherapy for lymphoma: a prospective study, Journal of Clinical Oncology. 2014, 32(33): 3736-43.
Seto W.K.W., Tanaka Y., Wong D.K.H., Shinkai N., Cheung K.S., Liu S.H.K., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Longitudinal serologic profiles up to 5 years in hepatitis B surface antigen-negative chronic hepatitis B, Hepatology. 2014, 60, No. 4 (Suppl): 57A.
Wong D.K.H., Effect of hepatitis B virus reverse transcriptase variations on entecavir treatment response, State Key Laboratory for Liver Research Annual Joint Forum With Shanghai Laboratories 2014. 两地三方肝病研究学术研讨会 2014, 2014.
Wong D.K.H., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Zhang J., Hung I.F.N., Lai C.L. and Yuen R.M.F., Identification of Hepatitis B Virus DNA Polymerase Sequences to Predict Virological Response to Entecavir Therapy, Health Research Symposium 2014, Hong Kong, 15 Nov 2014. (Poster presentation). 2014.
Wong D.K.H., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Identification of hepatitis B virus DNA reverse transcriptase variants associated with partial response to entecavir, Hong Kong Medical Journal. 2015, 21(Suppl 4): 35-8.
Wong D.K.H., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Hung I.F.N., Young J.L.P., Yuen J.C.H., Ngai W.S., Yuen R.M.F. and Lai C.L., Reduction of hepatitis B core related antigen by long term nucleoside nucleotide analogue therapy and its correlation with intrahepatic HBV DNA reduction, 24th Annual Conference of APASL, March 12–15, 2015, Istanbul, Turkey. Hepatology International. 2015, 9 (Suppl 1): S202.
ZHANG A., Wong D.K.H., Huang F.Y., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Evolutionary changes of hepatitis B virus pre-S mutations prior to development of hepatocellular carcinoma, Poster presentation at the International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2015, 62(Suppl 2): S543.


Researcher : Wong HYH
List of Research Outputs

Chiu J.W.Y., Wong H.Y.H., Leung R.C.Y., Pang R.W.C., Cheung T.T., Fan S.T., Poon R.T.P. and Yau T.C.C., Advanced Pancreatic Cancer: Flourishing Novel Approaches in the Era of Biological Therapy, Oncologist. 2014.


Researcher : Wong KL
List of Research Outputs

Jim M.H., Wong K.L. and Yiu K.H., Angiographic and clinical results of everolimus-eluting stent utilization in saphenous vein graft lesions (ARES)., Int J Cardiol. 2015. 2015, 184: 433-435.
Lee S.W.L., Lam S.C.C., Kong S.L., Chan K.W.K., Tam C.C., Wong K.L., Wong A.Y.T., Yung A.S.Y., Shea C.P., Zhang L. and Wu K.Y.K., TCT-367 2-Year Sequential OCT Follow-up Findings and 3-Year Clinical Outcomes of the New Dual Therapy Endothelial Progenitor Cell Capturing Sirolimus-eluting COMBO Stent: The EGO-COMBO Study, Journal of the American College of Cardiology. 2014, 64: B107.


Researcher : Wong KY
Project Title:Epigenetic regulation of tumour suppressor miR-33b in multiple myeloma
Investigator(s):Wong KY, Chim JCS
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:04/2013
Completion Date:03/2015


List of Research Outputs

Chim J.C.S. and Wong K.Y., Bortezomib/bendamustine/dexamethasone induced good partial response in refractory relapse post-ASCT with constitutive RAS activation due to V600E BRAF mutation, Bone Marrow Transplantation. 2014, in press.
YIM L.H.R., Wong K.Y., Kwong Y.L., Loong F., Leung C.Y., Chu R., Lam W.W., Hui P.K., Lai R. and Chim J.C.S., Methylation of miR-155-3p in mantle cell and other non-Hodgkin's lymphoma, Oncotarget. 2014, in press.


Researcher : Wong LYF
Project Title:Involvement of NF-κB and cAMP-dependent protein kinase pathways in adrenomedullin-induced cytokine responses in macrophages
Investigator(s):Wong LYF, Cheung BMY
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2004


Project Title:Mechanism of the modulation of cytokine responses by adrenomedullin and adrenomedullin binding protein-1 in macrophages: a novel pathway in sepsis with therapeutic implications
Investigator(s):Wong LYF, Cheung BMY
Department:Medicine
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:10/2006




Researcher : Wong RWM
List of Research Outputs

Tan V.P.Y., Wong B.C.Y., Wong R.W.M., Leung W.K., Tong D.K.H., Yuen R.M.F. and Fass R., Gastroesophageal reflux disease: cross-sectional study demonstrating rising prevalence in a Chinese population, J Clin Gastroenterol. 2015, Epub ahead of print.


Researcher : Wong RWS
List of Research Outputs

Au Y.L.E., Wong R.W.S., Mok T.M.Y., Chung H.Y., Chan Y.T.E. and Lau W.C.S., Disease activity assessment in ankylosing spondylitis in a Chinese cohort: BASDAI or ASDAS?, Clinical Rheumatology . 2014, 33: 1127-1134.
ZHANG J., Zhang L., ZHANG Y., Yang J., Guo M., Sun L., Pan H.F., Hirankarn N., Ying D., ZENG S., Lee T.L., Lau W.C.S., Chan T.M., Leung A.M.H., Mok C.C., Wong S.N., Lee K.W., Ho M.H.K., Lee P.P.W., Chung B.H.Y., Chong C.Y., Wong R.W.S., Mok W.C.L., Wong W.H.S., Tong K.L., Tse N.K.C., LI X.P., Avihingsanon Y., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Shotelersuk V., Ying S.K.S., Fung S.K.S., Lai W.M., Garcia-Barcelo M.M., Cherny S.S., Sham P.C., Yong C., Yang S., Ye D.Q., Zhang X.J., Lau Y.L. and Yang W., Gene-based meta-analysis of GWAS data identifies independent SNPs in ANXA6 as associated with SLE in Asian populations, Arthritis & Rheumatology. 2014.
ZHANG Y., Yang J., ZHANG J., Sun L., Hirankarn N., Pan H.F., Lau W.C.S., Chan T.M., Lee T.L., Leung A.M., Mok C.C., ZHANG L., WANG Y., Shen J.J., Wong S.N., Lee K.W., Ho M.H.K., Lee P.P.W., Chung B.H.Y., Chong C.Y., Wong R.W.S., Mok T.M.Y., Wong W.H.S., Tong K.L., Tse N.K.C., LI X.P., Avihingsanon Y., Rianthavorn P., SDeekajorndej T., Shotelersuk V., Suphapeetiporn K., Shotelersuk V., Ying S.K.Y., Fung S.K.S., Lai W.M., Wong C.M., Ng I.O.L., Sham P.C., Garcia-Barcelo M.M., Cherny S.S., Cui Y., Sham P.C., Yang S., Ye D.Q., Zhang X.J., Lau Y.L. and Yang W., Genome-wide search followed by replication reveals genetic interaction of CD80 and ALOX5AP associated with systemic lupus erythematosus in Asian populations, Annuals of Rheumatic Diseases. 2015.
Zhang Y., ZHANG J., Yang J., WANG Y., ZHANG L., Zuo X., Sun L., Pan H.F., Hirankarn N., WANG T., CHEN R., Ying D., Shen J.J., Lee T.L., Lau W.C.S., Chan D.T.M., Leung A.M.H., Mok C.C., Wong S.N., Lee K.W., Ho M.H.K., Lee P.P.W., Chung B.H.Y., Chong C.Y., Wong R.W.S., Mok T.M.Y., Wong W.H.S., Tong K.L., Tse N.K.C., Li X.P., Avihingsanon Y., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Shotelersuk V., Ying S.K.Y., Fung S.K.S., Lai W.M., Wong C.M., Ng I.O.L., Garcia-Barcelo M.M., Cherny S.S., Tam P.K.H., Sham P.C., Yang S., Ye D.Q., Cui Y., Zhang X.J., Lau Y.L. and Yang W., Meta-analysis of GWAS on two Chinese populations followed by replication identifies novel genetic variants on the X chromosome associated with systemic lupus erythematosus, Human Molecular Genetics. 2015, 24(1): 274-284.
Zhang Y., Wang Y., Yang J., ZHANG J., Sun L., Hirankarn N., Pan C.F., Lau W.C.S., Chan T.M., Lee T.L., Leung A.M.H., Mok C.C., ZHANG L., SHEN J., Wong S.N., Lee K.W., Ho M.H.K., Lee P.P.W., Chung B.H.Y., Chong C.Y., Wong R.W.S., Mok T.M.Y., Wong W.H.S., Tong K.L., Tse N.K., Li X.P., Avihingsanon Y., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Shotelersuk V., Ying S.K., Fung S.K., Lai W.M., Wong C.M., Ng I.O.L., Garcia-Barcelo M.M., Cherny S.S., Tam P.K.H., Sham P.C., Yang S., Ye D.Q., Cui Y., Zhang X.J., Yang W. and Lau Y.L., Meta-analysis of two Chinese populations identifies an autoimmune disease risk allele in 22q11.21 as associated with systemic lupus erythematosus, Arthritis Research & Therapy. 2015, 17: 67.


Researcher : Wong Y
List of Research Outputs

Tan K.C.B., Lee C.H., Shiu S.W.M. and Wong Y., Association between Serum Concentrations of Soluble Lectin-Like Oxidized Low Density Lipoprotein Receptor-1 and Serum Amyloid A in Type 2 Diabetes., The 10th International Diabetes Federation Western Pacific Region Congress, Singapore, Nov 2014.
Tan K.C.B., Shiu S.W.M. and Wong Y., Cellular Expression of Receptors for Circulating Advanced Glycation End Products in Type 2 Diabetes., American Diabetes Association 75th Scientific Sessions, Boston, June 2015.. 2015.
Tsun J.G., Shiu S.W.M., Wong Y. and Tan K.C.B., Impaired Macrophage Cholesterol Efflux in Poorly Controlled Type 2 Diabetes Mellitus., 17th International Symposium on Atherosclerosis, Amsterdam, May 2015.. 2015.


Researcher : Wong YK
List of Research Outputs

Lau G.K.K., Wong Y.K., Teo K.C., Li O.Y., Chan J., Chan S., Cheung R., Wong E., Wong E., Ho S.L., Mak H.K.F. and Rothwell P.M., Clinical correlates and prognostic implications of cerebral microbleeds detected by susceptibility weighted imaging in Chinese with ischaemic stroke, 10th International Symposium of Healthy Aging. 2015.
Lau G.K.K., Wong Y.K., Teo K.C., Li O.Y., Chan J., Chan S., Cheung R., Wong E., Wong E., Ho S.L., Mak H.K.F. and Rothwell P.M., Clinical correlates and prognostic implications of cerebral microbleeds detected by susceptibility weighted imaging in Chinese with ischaemic stroke, European Stroke Organisation Conference. 2015.
Lau G.K.K., Chan L.K., Li O.Y., Yuen T.K., Wong Y.K., Chan K.H., Chan J.F.W., Chang S.K.R., Cheung R.T.F., Doherty I., Ho S.L., Hon F.K.S., Kwan S.K.J., Lee R., Leung G.K.K., Mak W., Mak H.K.F., Shih K.C. and Tsang C.O.A., Establishing an eLearning Platform in Clinical Neurosciences, East-West Alliance Global Symposia 2014.
Lau G.K.K., Wong Y.K., Chan Y.H., Li O.Y., Lee P.Y.S., Yuen G.G., Wong Y.K., Tong S., Wong D. and Chan K.H., Mediterranean-Style Diet Is Associated With Reduced Blood Pressure Variability and Subsequent Stroke Risk in Patients With Coronary Artery Disease, American Journal of Hypertension. 2015, 28: 501-507.


Researcher : Woo YC
List of Research Outputs

Cheung Y.Y., Hui Y.L.E., Cheung B.M.Y., Woo Y.C., Xu A., Fong H.Y., Ong K.L., Yeung C.Y., Janus E.D., Tse H.F., Sham P.C. and Lam K.S.L., Adiponectin gene variants and the risk of coronary heart disease: a 16-year longitudinal study., Eur J Endocrinol. 2014, 171: 107-115.
Hui Y.L.E., Yeung C.Y., Lee P.C.H., Woo Y.C., Fong H.Y., Chow W.S., Xu A. and Lam K.S.L., Elevated Circulating Pigment Epithelium-Derived Factor Predicts the Progression of Diabetic Nephropathy in Patients With Type 2 Diabetes, The Journal of Clinical Endocrinology & Metabolism. 2014, 99: E2169-E2177.
Lang H.H.B., Yu H.W., Lo C.Y., Lee K.E., Garcia-Barcelo M.M., Woo Y.C., Lee P.C., Wong K.P., Tam P.K.H. and Lam K.S., Bilateral pheochromocytomas in MEN2A syndrome: a two-institution experience, World Journal of Surgery. 2015, Epub 2015-06-13.
Lee C.H.P., Hui Y.L.E., Woo Y.C., Yeung C.Y., Chow W.S., Yuen M.A.M., Fong H.Y., Xu A. and Lam K.S.L., Circulating Fibroblast Growth Factor 21 Levels Predict Progressive Kidney Disease in Subjects With Type 2 Diabetes and Normoalbuminuria, The Journal of Clinical Endocrinology & Metabolism. 2015, 100: 1368-1375.
Lee C.H.P., Woo Y.C., Wang Y., Yeung C.Y., Xu A. and Lam K.S.L., Obesity, adipokines and cancer: an update, Clinical Endocrinology. 2014, 83(2): 147-156.
Lee C.H.P., Woo Y.C., Fong C., Pau H.Y.N., Lam K.S.L. and Tan K.C.B., Validation of the Pooled Cohort Equations in a Hong Kong Chinese Cohort., 17th International Symposium on Atherosclerosis, Amsterdam, May 2015.
Woo Y.C., Cheung B.M.Y., Yeung C.Y., Lee C.H.P., Hui Y.L.E., Fong H.Y., Tso A.W.K., Tam S. and Lam K.S.L., Cardiometabolic risk profile of participants with prediabetes diagnosed by HbA1c criteria in an urban Hong Kong Chinese population over 40 years of age , Diabetic Medicine. 2015, n/a-n/a.


Researcher : Wu CH
List of Research Outputs

Lai C.L., Wong D.K.H., Ip P.C.P., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lee B.P., Cullaro G., Wu C.H., Cheng C.T.K., Yuen J.C.H., Ngai W.S. and Yuen R.M.F., Profound Reduction of HBV Covalently Closed Circular DNA with Long-term Nucleoside/tide Analogue Therapy, Hepatology. 2014, 60, No. 4 (Suppl): 183A.


Researcher : Wu H
List of Research Outputs

LI R., Yiu W.H., Wu H., LIN M., WONG W.L.D., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., BMP7 Reduces Tubular Inflammation and Oxidative Stress in Diabetic Nephropathy, J Am Soc Nephrol. 2014, 25: 216A.
LI R., Yiu W.H., Wu H., WONG W.L.D., Chan Y.Y., LIN M., Leung J.C.K., Lai K.N. and Tang S.C.W., BMP7 reduces inflammation and oxidative stress in diabetic tubulopathy, Clinical Science [IF 5.629]. 2015, 128(4): 269-280.
WU H., Lo Y., LUK T.W., Lau C.S., Lu L.W. and Mok T.M.Y., Alternatively activated dendritic cells derived from systemic lupus erythematosus patients have tolerogenic phenotype and function.European League of Association of Rheumatology (EULAR) 2015 Annals of the Rheumatic Diseases 2015; 74(Suppl2), 2015, 74(Suppl2): 951.
WU H., Lo Y., Luk D., Lau W.C.S., Lu L. and Mok T.M.Y., Alternatively activated dendritic cells derived from systemic lupus erythematosus patients have tolerogenic phenotype and function, Clinical Immunology. 2015, 156: 43-57.
WU H., Lo Y., LUK T.W., Lau C.S., Lu L. and Mok T.M.Y., Alternatively activated dendritic cells derived from systemic lupus erythematosus patients have tolerogenic phenotype and function, Hong Kong Medical Journal 2015;21:p55 (Abstract 90) . 2015.
WU H., Lo Y., LUK T.W., Chan W.K. and Mok T.M.Y., Bone marrow derived dendritic cells modified by lentiviral-mediated RelB shRNA possess tolerogenic phenotype and functions on lupus splenic lymphocytes. European League of Association of Rheumatology (EULAR) 2015. Ann Rheum Dis 2015; 74(Suppl2), 2015, 74(Suppl2): 951.
WU H. and Mok T.M.Y., The generation and therapeutic application of tolerogenic dendritic cells in systemic lupus erythematosus, PhD thesis. 2014.


Researcher : XIE B
List of Research Outputs

Fan J., Cheung R.T.F., Chu L.W., Fung P.C.W., Chang C.Q., Sik H.H., ZHANG M., XIE B. and Gao J., Reduced bilateral temporal Alpha-band EEG activity during resting state in older adults, International Conference on Digital Signal Processing. Hong Kong, 2014.
ZHANG M., XIE B., Mak H.K.F. and Cheung R.T.F., Cognitive impairments in patients with severe periventricular hyperintensities, Twentieth Medical Research Conference, Department of Medicine, The University of Hong Kong. 2015, 21 (Suppl 1): 59.


Researcher : XU J
List of Research Outputs

XU J., Lee Y.K., Wang Y. and Tse H.F., Therapeutic Application of Endothelial Progenitor Cells for Treatment of Cardiovascular Diseases, Current Stem Cell Research & Therapy. 2014, 401-414 (14).


Researcher : Xia HHX
Project Title:Homeobox genes in gastric carcinogenesis: an in vivo and in vitro study
Investigator(s):Xia HHX, Wong BCY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2003


Project Title:Role of cyclooxygenase in helicobacter pylori-induced gastric carcinogenesis
Investigator(s):Xia HHX, Wong BCY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2004


Project Title:Role of macrophage migration inhibitory factor in Helicobacter pylori-induced gastric carcinogenesis
Investigator(s):Xia HHX, Wong BCY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2005




Researcher : Xiong J
Project Title:2008 NCRI Cancer Conference Growth inhibitory effect of 5-aza-2'-deoxycytidine on cancer cells is independent of p16 ink4a and p14ARF
Investigator(s):Xiong J
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2008




Researcher : Xu A
Project Title:Molecular mechanism underlaying the pathogenesis of type 2 diabetes
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:05/2007


Project Title:Genetic and pathogenic pathways leading to type 2 diabetes Mellitus
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:05/2011


Project Title:71th Scientific Sessions of the American Diabetes Association Genetic Inactivation of Toll-Like Receptor 4 Alleviates Diet-Induced Nonalcoholic Steatohepatitis by Inhibiting Reactive Oxygen Species-Evoked Activation of X-box Binding Protein-1 in ApoE-Deficient Mice
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2011


Project Title:A Multi-disciplinary Approach to Investigate Vascular Dysfunction in Obesity and Diabetes: From Molecular Mechanism to Therapeutic Intervention
Investigator(s):Xu A, Vanhoutte PMGR, Wang Y, Lam KSL
Department:Medicine
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2011
Completion Date:04/2015


Project Title:The Liver-derived Hormone FGF21 as a Novel Regulator of Vascular Function: Molecular Basis and Physiological Implications
Investigator(s):Xu A, Vanhoutte PMGR
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2012


Project Title:The adaptor protein APPL1 as a physiological regulator of insulin secretion in pancreatic ?cells
Investigator(s):Xu A, Cheng KY
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2013


Project Title:Physical exercise promotes vascular health: impact of mechano-transduction and novel endothelium-derived regulators
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2013


Project Title:Adipocyte fatty acid binding protein as a mediator of obesity-related medical complications
Investigator(s):Xu A, Hoo RLC
Department:Medicine
Source(s) of Funding:Germany/Hong Kong Joint Research Scheme
Start Date:01/2014


Project Title:Fibroblast growth factor 21 maintains glucose homeostasis during fasting by mediating the crosstalk between liver and brain
Investigator(s):Xu A, Cheng KY
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2014


Project Title:Targetting Neutrophil Serine Proteases for Management of Autoimmune Diabetes
Investigator(s):Xu A, Lam KSL
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Applied Research
Start Date:06/2014


Project Title:FGF21 resistance in obese adipose tissues as a mediator of systemic insulin resistance: molecular mechanisms and clinical significance
Investigator(s):Xu A, Hui X
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2014


Project Title:Fatty acid binding protein-4 as a mediator of autoimmune diabetes: from molecular mechanism to clinical significance
Investigator(s):Xu A, Lam KSL
Department:Medicine
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2015


Project Title:Interplay between Adiponectin and Alternatively-activated Macrophages in Cold-induced Remodeling and Adaptive Thermogenesis of White Adipose Tissues
Investigator(s):Xu A, Hui X
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2015


Project Title:FGF21 resistance as a potential mediator of systemic insulin resistance and type 2 diabetes
Investigator(s):Xu A, Lam KSL, Chan YCC
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2015


Project Title:Development of innovative chemiluminescent immunoassays for diabetes and its cardiovascular complications
Investigator(s):Xu A, Cheung BMY, Zhang J, Zhou P, Wang Y, Choi L
Department:Medicine
Source(s) of Funding:Matching Grant for Joint Research
Start Date:04/2015


Project Title:Neutrophil-derived proteinase 3 as a new player in the pathogenesis of obesity-induced non-alcoholic steatohepatitis
Investigator(s):Xu A, Ye D
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2015


Project Title:A Multi-disciplinary Approach to Investigate Vascular Dysfunction in Obesity and Diabetes: From Molecular Mechanism to Therapeutic Intervention
Investigator(s):Xu A, Cheng KY, Lam KSL, Vanhoutte PMGR, Wang Y, Woo WHC, Wu EX
Department:Medicine
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2015


List of Research Outputs

BARETELLA O.M., Xu A. and Vanhoutte P.M.G.R., Interaction between IP, TP, and 5-HT2 receptors during contractions to prostacyclin in rat renal arteries, ASCEPT-BPS Joint Scientific Meeting, Tomorrow's medicines: pharmacology, patients and populations, May 19-21, 2015, Hong Kong. 2015.
BARETELLA O.M., Xu A. and Vanhoutte P.M.G.R., Prostagiandin 12 Receptor blockade Contracts Rat Renal Arteries and Facilitates Endothelium-Dependent Contractions, High Blood Pressure Research 2014, September 9-12, 2014 San Francisco, CA. 2014.
BARETELLA O.M., Xu A. and Vanhoutte P.M.G.R., Role of IP receptors in renal basal arterial tone and endothelium-dependent contractions, Eighteenth Annual Scientific Meeting, Institute of Cardiovascular Science and Medicine, November 1, 2014, Hong Kong. 2014.
Baretella O.M., Xu A. and Vanhoutte P.M.G.R., Increase in vasomotor tone upon IP receptor blockade in isolated murine renal arteries-role of lipoxygenase(s), 17th World Congress of Basic & Clinical Pharmacology, July 13-18, 2014, Cape Town, South Africa. 2014.
CAI Y., MANIO M.M., Leung G.P.H., Xu A., Tang E.H.C. and Vanhoutte P.M.G.R., Thyroid hormone affects both endothelial and vascular smooth muscle cells in rat arteries, European Journal of Pharmacology. 2015, 747: 18-28.
CHEN J., Xu A. and Woo W.H.C., Regulation of Lipogenesis by Toll like receptor pathway: Effect on Stearyl-CoA Desaturase-1, Tenth International Symposium on Healthy Aging, "A Decade of Positive Aging", March 7-8, 2015, Hong Kong. 2015.
CHEN Z., Cheng K.Y. and Xu A., Adaptor protein APPL1 counteracts streptozotocin-induced diabetes in mice., Diabetes Congress 2015.
Chen J., Yang M., Zhao K., Xu A. and Huang Q., Polymorphisms in FTO, TMEM18 and PCSK1 are associated with BMI in southern Chinese population, Journal of Genetics. 2014, 93(2): 509-512.
Cheng Q., Ng K.T.P., Xu A., Li C.X., Liu X.B., Guo D.Y., Poon R.T.P., Fan S.T., Lo C.M. and Man K., The Roles of Lipocalin-2 in Small-for-Size Fatty Liver Graft Injury, Annals of Surgery. 2014, 260(6): 1062-1072.
Cheung Y.Y., Hui Y.L.E., Cheung B.M.Y., Woo Y.C., Xu A., Fong H.Y., Ong K.L., Yeung C.Y., Janus E.D., Tse H.F., Sham P.C. and Lam K.S.L., Adiponectin gene variants and the risk of coronary heart disease: a 16-year longitudinal study., Eur J Endocrinol. 2014, 171: 107-115.
DETREMMERIE C.M.S., Leung S.W.S., Xu A., Gao Y. and Vanhoutte P.M.G.R., Endothelium-, soluble guanylyl cyclase-dependent contractions in isolated arteries, Eighteenth Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine “Bridging Translational Gap”, 1 Nov 2014, Hong Kong. 2014.
DETREMMERIE C.M.S., Leung S.W.S., Xu A., Gao Y. and Vanhoutte P.M.G.R., Endothelium-dependent vasoconstrictor signals requiring activation of soluble guanylyl cyclase in isolated arteries, ASCEPT-BPS Joint Scientific Meeting "Tomorrow's medicines: pharmacology, patients and populations" 2015, 19-21 May 2015, Hong Kong. 2015.
DETREMMERIE C.M.S., Leung S.W.S., Xu A., Alkharfy K., Gao Y. and Vanhoutte P.M.G.R., Thymoquinone as a pharmacological tool to study the endothelium-dependent, soluble guanylyl cyclase-dependent augmentation caused by hypoxia in isolated arteries , 17th World Congress of Basic and Clinical Pharmacology, 13 to 18 July, 2014, Cape Town, South Africa. 2014.
Deng H., Huang B., Xu C., Park S., Xu A., Lee I.K. and Wang Y., Reduced Clusterin Contents Contribute to The Pro-Inflammatory and Pro-Senescent Activity of Low Density Lipoprotein Particles in Adiponectin Deficient Mice, The 9th Congress of the Asian-Pacific Society of Atherosclerosis and Vascular Disease and 16th Diabetes and Cardiovascular Risk Factor – East Meets West Symposium. Japan, Japan Atherosclerosis Society, 2014, 21: S34.
Esmaili S., Xu A. and George J., The multifaceted and controversial immunometabolic actions of adiponectin, Trends in Endocrinology & Metabolism. 2014, 25(9): 444-451.
Gu P., Hui X., Vanhoutte P.M.G.R., Lam K.S.L. and Xu A., Deletion of SIRT1 in perivascular adipose tissue accelerates obesity-induced endothelial dysfunction , ASCEPT-BPS2015.
Huang B., Cheng X., Wang D., Peng M., Xue Z., Da Y., Zhang N., Yao Z., Li M., Xu A. and Zhang R., Adiponectin promotes pancreatic cancer progression by inhibiting apoptosis via the activation of AMPK/Sirt1/PGC-1α signaling, Oncotarget. 2014, 5(13): 4732-4745.
Hui Y.L.E., Yeung C.Y., Lee P.C.H., Woo Y.C., Fong H.Y., Chow W.S., Xu A. and Lam K.S.L., Elevated Circulating Pigment Epithelium-Derived Factor Predicts the Progression of Diabetic Nephropathy in Patients With Type 2 Diabetes, The Journal of Clinical Endocrinology & Metabolism. 2014, 99: E2169-E2177.
Hui Y.L.E., Xu A., Chow W.S., Lee P.C.H., Fong H.Y., Cheung C.W.S., Tse H.F., Chau M.T., Cheung B.M.Y. and Lam K.S.L., Hypoadiponectinemia As an Independent Predictor for the Progression of Carotid Atherosclerosis: A 5-Year Prospective Study, Metabolic Syndrome and Related Disorders. 2014, 12: 517-522.
KWOK H.M., Cheng K.Y., Li F.Y.L., Chan Y.C.C., Hoo R.L.C., Ye D., Xu A. and Lam K.S.L., Inactivation of c-Jun N-terminal Kinase in Adipose Tissue Alleviates Atherosclerosis in Diet-induced Obese ApoE-deficient Mice, 83rd European Atherosclerosis Society Congress. 2015.
Lam K.S.L., Chan Y.C.C., Stillitano A., Wong C.M., Pang Y. and Xu A., Adipose tissue FGF21 resistance contributes to hypoadiponectinemia and insulin resistance in obesity: Role of miR-34a, The 75th Scientific Sessions of the American Diabetes Association, 5-9 Jun 2015, Boston, USA. 2015.
Lee C.H.P., Hui Y.L.E., Woo Y.C., Yeung C.Y., Chow W.S., Yuen M.A.M., Fong H.Y., Xu A. and Lam K.S.L., Circulating Fibroblast Growth Factor 21 Levels Predict Progressive Kidney Disease in Subjects With Type 2 Diabetes and Normoalbuminuria, The Journal of Clinical Endocrinology & Metabolism. 2015, 100: 1368-1375.
Lee C.H.P., Woo Y.C., Wang Y., Yeung C.Y., Xu A. and Lam K.S.L., Obesity, adipokines and cancer: an update, Clinical Endocrinology. 2014, 83(2): 147-156.
Li H., Hui X., Li K., Tang X., Hu X., Xu A. and Wu D., High-level expression, purification and characterization of active human C1q and tumour necrosis factor-related protein-1 in Escherichia coli , Letters in Applied Microbiology. 2014, 59(3): 334-341.
Liang Q., Zhong L., Zhang J., Wang Y., Bornstein S.R., Hong D., Triggle C. and Xu A., FGF21 Maintains Glucose Homeostasis by Mediating the Cross Talk Between Liver and Brain During Prolonged Fasting., Diabetes. 2014, Jul 14 Epub ahead of print.
Lin Z., Pan X., Wu F., Ye D., Zhang Y., Wang Y., Jin L., Lian Q., Huang Y., Ding H., Triggle C., Wang K., Li X. and Xu A., Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice, Circulation. 2015, 131(21): 1861-1871.
Liu T., Li H., Gounko N.V., Zhou Z., Xu A., Hong W. and Han W., Detection of insulin granule exocytosis by an electrophysiology method with high temporal resolution reveals enlarged insulin granule pool in BIG3-knockout mice, AJP: Endocrinology and Metabolism. 2014, 307(7): E611-E618.
Liu Y., Palanivel R., Rai E., Park M., Gabor T.V., Scheid M.P., Xu A. and Sweeney G., Adiponectin stimulates autophagy and reduces oxidative stress to enhance insulin sensitivity during high fat diet feeding in mice., Diabetes. 2014, July 28 Epub ahead of print.
Liu Y., Wu G., Han L., Zhao K., Qu Y., Xu A. and Huang Q., Association of the FABP2 Ala54Thr polymorphism with type 2 diabetes, obesity, and metabolic syndrome: a population-based case-control study and a systematic meta-analysis, Genetics and Molecular Research. 2015, 14(1): 1155-1168.
Liu Y., Sen S., Wannaiampikul S., Palanivel R., Hoo R.L.C., Isserlin R., Bader G., Tungtrongchitr R., Deshaies Y. and Xu A., Metabolomic profiling in liver of adiponectin knockout mice uncovers lysophospholipid metabolism as an important target of adiponectin action, Biochemical Journal. 2015, 469(1): 71-82.
Ng C.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Lam K.S.L., Xu A. and Chan K.H., Adiponectin deficiency induced cognitive dysfunction and Alzheimer’s disease pathogenesis in mice through the disruption of insulin sensitivity and inactivated AMPK signaling , 67th American Academy of Neurology Annual Meeting. 2015.
Ng C.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Lam K.S.L., Xu A. and Chan K.H., Research Travel Scholarship 2015, American Academy of Neruology. 2015.
Ng K.T.P., Xu A., Cheng Q., Guo D.Y., Lim Z.X., Sun C.K., Fung H.S.J., Poon R.T.P., Fan S.T., Lo C.M. and Man K., Clinical relevance and therapeutic potential of angiopoietin-like protein 4 in hepatocellular carcinoma, Molecular Cancer. 2014, 13: 196-213.
Nie T., Hui X., Gao X., Nie B., Mao L., Tang X., Yuan R., Li K., Li P. and Xu A., Conversion of non-adipogenic fibroblasts into adipocytes by a defined hormone mixture, Biochemical Journal. 2015, 467(3): 487-494.
Ong K.L., Januszewski A.S., O’Connell R., Jenkins A.J., Xu A., Sullivan D.R., Barter P.J., Hung W.T., Scott R.S. and Taskinen M.R., The relationship of fibroblast growth factor 21 with cardiovascular outcome events in the Fenofibrate Intervention and Event Lowering in Diabetes study, Diabetologia. 2015, 58(3): 464-473.
Palanivel R., Ganguly R., Turdi S., Xu A. and Sweeney G., Adiponectin stimulates Rho-mediated actin cytoskeleton remodeling and glucose uptake via APPL1 in primary cardiomyocytes, Metabolism. 2014, 63(10): 1363-1373.
Ramezani-Moghadam M., Wang J., Ho V., Iseli T.J., Alzahrani B., Xu A., Van der Poorten D., Qiao L., George J. and Hebbard L., Adiponectin Reduces Hepatic Stellate Cell Migration by Promoting Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) Secretion, Journal of Biological Chemistry. 2015, 290(9): 5533-5542.
SHU L., WU X., CHEONG L.Y., Zhou M., Lam K.S.L., Xu A. and Hoo R.L.C., Adipocyte fatty acid binding protein (A-FABP) is a potential regulator of adaptive thermogenesis, Tenth international symposium on healthy aging"A decade of positive aging ". 2015.
So W.Y., Cheng Q., Xu A., Lam K.S.L. and Leung P.S., Loss of fibroblast growth factor 21 action induces insulin resistance, pancreatic islet hyperplasia and dysfunction in mice, Cell Death and Disease. 2015, 6: e1707.
Song E., Fan P., Huang B., Deng H., Feletou M., Vilaine J.P., Villeneuve N., Xu A., Vanhoutte P.M.G.R. and Wang Y., Linoleic Acid induced Activation of Lipocalin-2 Causes Endothelial Dysfunction and Hypertension in Obese Mice, U21 Graduate Research Conference 2014 Celebrating Ageing Research, University of Auckland, New Zealand, July 1-4, 2014.
Tang E.H.C., Cai Y., Wong C.K., Rocha V.Z., Sukhova G.K., Shimizu K., GE X., Vanhoutte P.M.G.R., Libby P. and Xu A., Activation of prostaglandin E2-EP4 signaling reduces chemokine production in adipose tissue , Journal of Lipid Research. 2015, 56(2): 358-368.
WANG B., Cheng K.Y., Li X., Lam K.S.L. and Xu A., Hypothalamic APPL2 combats against obesity by promoting adaptive thermogenesis in white adipose tissues, EMBL Symposium: Translating Diabetes.. 2015.
WANG B., Cheng K.Y., Li X., Li A., Lam K.S.L. and Xu A., The Role of Hypothalamic APPL2 in Regulation of Energy Expenditure in Adipose Tissues, 2015 Asia Pacific obesity and diabetes symposium.. 2015.
WANG B., Cheng K.Y., Li X., Li A., Lam K.S.L. and Xu A., The hypothalamic APPL2 as a novel regulator of energy homeostasis in adipose tissues, The 10th International Symposium on Healthy Aging 2015. A Decade of Positive Aging. 2015.. 2015.
WANG Y., Xiao Y., ZHONG L., Ye D., Zhang J., Tu Y., Bornstein S.R., Zhou Z., Lam K.S.L. and Xu A., Increased Neutrophil Elastase and Proteinase 3 and Augmented NETosis Are Closely Associated With  -Cell Autoimmunity in Patients With Type 1 Diabetes, Diabetes. 2014, 63: 4239-4248.
Wong C.M., WANG Y., LEE T.H.J., HUANG Z., Wu D., Xu A. and Lam K.S.L., Adropin is a brain membrane-bound protein regulating physical activity via NB-3/Notch signaling pathway in mice, The Journal of Biological Chemistry. 2014.
Wu G., Li H., Fang Q., Jiang S., Zhang L., Zhang J., Hou X., Lu J., Bao Y. and Xu A., Elevated Circulating Lipocalin-2 Levels Independently Predict Incident Cardiovascular Events in Men in a Population-Based Cohort, Arteriosclerosis, Thrombosis, and Vascular Biology. 2014, 34(11): 2457-2464.
Wu G., Li H., Zhou M., Fang Q., Bao Y., Xu A. and Jia W., Mechanism and clinical evidence of lipocalin-2 and adipocyte fatty acid-binding protein linking obesity and atherosclerosis, Diabetes/Metabolism Research and Reviews. 2014, 30(6): 447-456.
Xu A., Adiponectin, adipo-vascular axis and obesity-related cardiometabolic syndrome, The 3rd DMRC international symposium on drug discovery, Daegu, South Korea . 2014.
Xu A. and Sweeney G., Emerging role of autophagy in mediating widespread actions of ADIPOQ/adiponectin, Autophagy. 2015, 11(4): 723-724.
Xu A., FGF21 resistance in adipocytes as a possible cause of systemic insulin resistance , 2nd Asan International Symposium of Asan Diabetes Center , Seoul, Korea. 2014.
Xu C., CAI Y., Fan P., Bai B., CHEN J., Deng H., Che C.M., Xu A., Vanhoutte P.M.G.R. and Wang Y., Calorie Restriction Prevents Metabolic Aging Caused by Abnormal SIRT1 Function in Adipose Tissues, Diabetes. 2015, 64: 1576-1590.
Yau S.Y., LI A., Xu A. and So K.F., Fat cell-secreted adiponectin mediates physical exercise-induced hippocampal neurogenesis: an alternative anti-depressive treatment?, Neural Regeneration Research. 2015.
Yau S.Y., LI A., Hoo R.L.C., Ching Y.P., Christie B... .R..., Lee T.M.C., Xu A. and So K.F., Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin, Proceedings of the National Academy of Sciences. United States of America, Proceedings of the National Academy of Sciences of the US, 2014, 111: 15810-15815.
Ye D., Wang Y., Li H., Jia W., Man K., Lo C.M., Wang Y., Lam K.S.L. and Xu A., Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1α-mediated antioxidant capacity in mice, Hepatology. 2014, 60: 977-989.
ZHAO Y., Flavahan S., Leung S.W.S., Xu A., Vanhoutte P.M.G.R. and Flavahan N.A., Elevated pressure causes endothelial dysfunction in mouse carotid arteries by increasing local angiotensin signaling., Am J Physiol Heart Circ Physiol . 2015, 308: H358-H363.
Zhang Y., LIANG X., Liao S., Wang W., Wang J.J., LI X., Ding Y., LIANG Y., GAO F., Yang M., Fu Q., Xu A., Chai Y.H., He J., Tse H.F. and Lian Q., Potent Paracrine Effects of human induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Attenuate Doxorubicin-induced Cardiomyopathy, Scientific Reports. 2015, 5: 11235.
Zhou M., PAN Y., SHU L., Lam K.S.L., Xu A. and Hoo R.L.C., A-FABP is a potential mediator of diabetic cardiomyopathy and ischemic reperfusion induced cardiac injury , 17th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM) . 2014.


Researcher : YIM LHR
List of Research Outputs

YIM L.H.R., Wong K.Y., Kwong Y.L., Loong F., Leung C.Y., Chu R., Lam W.W., Hui P.K., Lai R. and Chim J.C.S., Methylation of miR-155-3p in mantle cell and other non-Hodgkin's lymphoma, Oncotarget. 2014, in press.


Researcher : Yang M
Project Title:Protective effect of thrombopoietin on iron-induced cardiomyopathy
Investigator(s):Yang M
Department:Paediatrics & Adolescent Med
Source(s) of Funding:Children's Thalassaemia Foundation - General Awards
Start Date:07/2007


Project Title:The effect of melatonin in the treatment of thrombocytopenia
Investigator(s):Yang M
Department:Paediatrics & Adolescent Med
Source(s) of Funding:Queen Mary Hospital Charitable Trust - Training and Research Assistance Scheme
Start Date:01/2008


Project Title:The protective effects of thrombopoietin and amlodipine on iron overload-induced human mesenchymal stem cell damage: its impact on iron overload related osteopenia & osteoporosis
Investigator(s):Yang M, Chan GCF, Cheung YF, Liu C
Department:Paediatrics & Adolescent Med
Source(s) of Funding:Children's Thalassaemia Foundation - General Awards
Start Date:01/2009


List of Research Outputs

Zhang Y., LIANG X., Liao S., Wang W., Wang J.J., LI X., Ding Y., LIANG Y., GAO F., Yang M., Fu Q., Xu A., Chai Y.H., He J., Tse H.F. and Lian Q., Potent Paracrine Effects of human induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Attenuate Doxorubicin-induced Cardiomyopathy, Scientific Reports. 2015, 5: 11235.


Researcher : Yap YHD
Project Title:A Therapeutic Drug Monitoring Program of Mycophenolic Acid in patients with Lupus Nephrities
Investigator(s):Yap YHD
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:12/2013


Project Title:Relationship between Mycophenolic Acid Pharmacokinetics and Pharmacogenomics with treatment response and disease activity in lupus nephritis
Investigator(s):Yap YHD, Ma KMM, Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2015


List of Research Outputs

Chan G.C.W., Yap Y.H.D., Kwan L.P., Chan J.F.W., Iu L.P.L., Wong Y.H.I. and Tang S.C.W., Progressive outer retinal necrosis in a renal transplant recipient: a rare treatment success, Transplant Infectious Disease. 2015, 17: 396-399.
Chan K.Y., Cheng H.W., Yap Y.H.D., Yip T., Li C.W., Sham M.K., Wong Y.C. and Lau W.K., Reduction of Acute Hospital Admissions and Improvement in Outpatient Attendance by Intensified Renal Palliative Care Clinic Follow-Up: The Hong Kong Experience, Journal of Pain and Symptom Management. 2015, 49: 144-149.
Cheung K.F., Yung S.S.Y., Yim A.S.Y., Chau K.M., Yap Y.H.D. and Chan D.T.M., Annexin II-binding IgG and IgM in sera of patients with lupus nephritis, 3rd International Conference on Immune Tolerance 2014.
Yap Y.H.D., Associate Editor, International Journal of Nephrology and Kidney Diseases. 2014.
Yap Y.H.D., Best Oral Abstract Presentation - 20th Medical Research Conference, Department of Medicine, The University of Hong Kong, Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong. 2015.
Yap Y.H.D., Ma K.M.M., Mok M.M., Kwan L.P., Chan G.C. and Chan D.T.M., Long-term data on tacrolimus treatment in lupus nephritis, Rheumatology. Oxford, 2014, 53(12): 2232-2237 [Epub 4 Jul 2014].
Yap Y.H.D., Yung S.S.Y., Zhang Q., Tang S.O.C. and Chan D.T.M., Mesangial cell-binding activity of serum immunoglobulin G in patients with lupus nephritis, PLoS One. 2014, 9(7): e101987.
Yap Y.H.D. and Lai K.N., Pathogenesis of Renal Disease in Systemic Lupus Erythematosus—The Role of Autoantibodies and Lymphocytes Subset Abnormalities, International Journal of Molecular Sciences. 2015, 16: 7917-7931.


Researcher : Yau TCC
Project Title:The Role of Serial Changes in Circulating Angiogenic Markers in Predicting the Clinical Outcome of Advanced Hepatocellular Carcinoma (HCC) Patients on Sorafenib
Investigator(s):Yau TCC, Fan ST, Poon RTP, Pang RWC
Department:Surgery
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2011


Project Title:A Pilot Study to Evaluate the Prophylactic Effects of Telbivudine for Prevention of Hepatitis B Reactivation in HBsAg Positive Patients Receiving Sorafenib Treatment for Advanced Hepatocellular Carcinoma
Investigator(s):Yau TCC, Poon RTP
Department:Surgery
Source(s) of Funding:Small Project Funding
Start Date:06/2012


Project Title:4th Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association; Systemic treatment of metastatic neuroendocrine tumors to the liver/Local-regional therapy for colorectal liver metastases
Investigator(s):Yau TCC
Department:Surgery
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:03/2013


Project Title:The Role of Insulin Growth Factor (IGF) Level in Cachexia and Treatment Outcome in Advanced Pancreatic Cancer Patients
Investigator(s):Yau TCC, Poon RTP
Department:Surgery
Source(s) of Funding:Small Project Funding
Start Date:06/2013


Project Title:A Phase II study of the safety and efficacy of PEG-BCT-100 combined with capecitabine/oxaliplatin in patients with advanced hepatocellular carcinoma (Part I)
Investigator(s):Yau TCC
Department:Medicine
Source(s) of Funding:Matching Grant for Joint Research
Start Date:04/2014


Project Title:Randomized Phase II Trial of Sorafenib, Capecitabine and Oxaliplatin (SECOX) versus Single Agent Sorafenib in Patients with Advanced Hepatocellular Carcinoma
Investigator(s):Yau TCC, Poon RTP
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:04/2015


List of Research Outputs

Chiu J.W.Y., Wong H.Y.H., Leung R.C.Y., Pang R.W.C., Cheung T.T., Fan S.T., Poon R.T.P. and Yau T.C.C., Advanced Pancreatic Cancer: Flourishing Novel Approaches in the Era of Biological Therapy, Oncologist. 2014.
Chiu W.Y.J., Leung R.C.Y., Suen T.K.D., Chen T.H.C., Chow C.Y.L., Kwok G., Wong H., Cheung P., Yau T.C.C. and Kwong A., A phase II study of neoadjuvant chemotherapy using combined taxane, anthracycline, and cyclophosphamide in high risk HER2-negative locally advanced breast cancer (Abstract & Oral Presentation), Global Breast Cancer Conference 2015 and the 4th International Breast Cancer Symposium, Jeju Island, Korea, 23-25 April 2015.
Chiu W.Y.J., Leung R.C.Y., Suen T.K.D., Chen T.H.C., Chow C.Y.L., Kwok G., Wong H., Cheung P. and Yau T.C.C., KBCF Scholarship on "A phase II study of neoadjuvant chemotherapy using combined taxane, anthracycline, and cyclophosphamide in high risk HER2-negative locally advanced breast cancer", Global Breast Cancer Conference 2015 and the 4th International Breast Cancer Symposium, Jeju Island, Korea, 23-25 April 2015. 2015.
Chiu W.Y.J., Serra S., Kamel-Reid S., Zhang T., McNamara M.G., Bedard P.L., Hedley D., Moore M., Dhani N.C., Shek T.W.H., Kwong Y.L., Yau T.C.C., Doherty M. and Knox J.J., Next generation sequencing: profiling gallbladder cancer, Gastrointestinal Cancers Symposium 2015.
Chiu W.Y.J., Yau T.C.C., Cheung T.T., Chan A.C.Y., Chok K.S.H., Dai W.C., Leung R., Chan S.C. and Lo C.M., Use of sorafenib in recurrent hepatocellular carcinoma after liver transplantation, Gastrointestinal Cancers Symposium 2015.
Ho E.Y., Yau T.C.C., Rousseau F. and Lau G.K., Preemptive Adefovir versus Lamivudine for Prevention of Hepatitis B Reactivation in Chronic Hepatitis B Patients Undergoing Chemotherapy, Hepatology International. 2015, 9: 224-230.
Li J., Qin S., Xu R., Yau T.C.C., Ma B., Pan H., Xu J., Bai Y., Chi Y., Wang L., Yeh K.H., Bi F., Cheng Y., Le A.T., Lin J.K., Liu T., Ma D., Kappeler C., Kalmus J. and Kim T.W., Regorafenib plus best supportive care versus placebo plus best supportive care in Asian patients with previously treated metastatic colorectal cancer (CONCUR): a randomised, double-blind, placebo-controlled, phase 3 trial, Lancet Oncology. 2015, 16: 619-629.
Poon R.T.P., Cheung T.T., Kwok P.C., Lee A.S., Li T.W., Loke K.L., Chan S.L., Cheung M.T., Lai T.W., Cheung C.C., Cheung F.Y., Loo C.K., But Y.K.D., Hsu A.S.J., Yu S.C. and Yau T.C.C., Hong Kong consensus recommendations on the management of hepatocellular carcinoma, Liver Cancer. 2015, 4(1): 51-69.
She W.H., Cheung T.T., Yau T.C.C., Chan A.C.Y., Chok K.S.H., Chu S.K.F., Liu K.Y., Poon R.T.P., Chan S.C., Fan S.T. and Lo C.M., Survival analysis of transarterial radioembolization with yttrium-90 for hepatocellular carcinoma patients with HBV infection, Hepatobiliary Surgery and Nutrition. 2014, 3(4): 185-193.
Yau T.C.C., Debate Advanced G2 NET: Case for TKIs, 2nd Asia Pacific Neuroendocrine Tumour Society Meeting, Kochi, India. 2014.
Yau T.C.C., Defining the boundary between surgery and TACE, The 5th Asia-Pacific Primary Liver Cancer Meeting. 2014.
Yau T.C.C., Distinguished Paper Award (Paper title not provided), Hong Kong College of Physicians. 2014.
Yau T.C.C., Does CONCUR CORRECT-ly concur in treatment settings of mCRC – The Asian Perspective, Asia Pacific Gastroenterology Cancer Summit 2014 Bayer Tea Symposium, Singapore. 2014.
Yau T.C.C., Does CONCUR CORRECT-ly concur in treatment settings of mCRC – The Asian Perspective, Research Meeting, Department of Medicine, National University Hospital of Singapore, Singapore. 2014.
Yau T.C.C., Drug Development for Advanced Hepatocellular Carcinoma, Hong Kong Sanatorium Hospital Tumour Board Meeting, Hong Kong. 2014.
Yau T.C.C., Emerging Therapies for Advanced Pancreatic Cancer Patients, IASGO World Congress 2014, Vienna, Austria. 2014.
Yau T.C.C., Future Perspective in the Management of metastatic CRC, CME Lecture, National Cancer Institute (Institut Kanser Negara-IKN), Kuala Lumpur, Malaysia. 2015.
Yau T.C.C., Future Perspectives in Breast Cancer Management, 2015 Latest Updates in Breast Cancer Management, Hong Kong Breast Cancer Foundation, Hong Kong. 2015.
Yau T.C.C., Hepatitis C Infection and Hepatocellular Carcinoma, Second Chinternational Hepatitis C Forum, Hong Kong. 2015.
Yau T.C.C., Latest biomarker developments for EGFR inhibitors in mCRC - An Update from Medical Oncologist’s Perspective, Ras Expert Forum. 2014.
Yau T.C.C., Medical Oncology News in Breast Cancer 2014, Updates in Breast Cancer Management. 2014.
Yau T.C.C., Neoadjuvant Therapy for Neuroendocrine Tumours, 2nd Asia Pacific Neuroendocrine Tumour Society Meeting, Kochi, India. 2014.
Yau T.C.C., Novel Therapies for Advanced Colorectal Cancer, Penang General Hospital Oncology CME Lecture, Penang, Malaysia. 2015.
Yau T.C.C., Optimal Staging System for Hepatocellular Carcinoma: Hong Kong versus Barcelona, The 9th Korean Cancer Study Group Symposium, Seoul, South Korea. 2015.
Yau T.C.C., Optimizing patient outcomes in mCRC – Does CONCUR CORRECT-ly concur?, Bayer Malaysia Satellite Symposium, Kuala Lumpur, Malaysia. 2015.
Yau T.C.C., Cheng N.P., Chan P., Chen L., Yuen J., Pang R.W.C., Fan S.T., Wheatley D.N. and Poon R.T.P., Preliminary efficacy, safety, pharmacokinetics, pharmacodynamics and quality of life study of pegylated recombinant human arginase 1 in patients with advanced hepatocellular carcinoma, Investigational New Drugs. 2015, 33(2): 496-504.
Yau T.C.C., Role of targeted therapies in the management of mCRC beyond progression & local experience sharing, Asia-Pacific Oncology Conference. 2014.
Yau T.C.C., Staging System for Hepatocellular Carcinoma: How Should it Affect the Management, 5th Asia-Pacific Hepato-Pancreato-Biliary Association Meeting, Singapore. 2015.
Yau T.C.C., Staging and Guidelines for HCC: NCCN, Barcelona or Hong Kong, World Congress of Interventional Oncology (WCIO) 2015, New York, United States. 2015.
Yau T.C.C., Staging for Hepatocellular Carcinoma: Hong Kong versus Barcelona, States Key Laboratory of Liver Research Symposium 2014, Hong Kong. 2014.
Yau T.C.C., Systemic Treatment in HCC: Is There Light at the End of the Tunnel?, Asia Pacific Gastroenterology Cancer Summit 2014, Singapore. 2014.
Yau T.C.C., Targeted Therapies For Esophageal and Gastric Cancer, MAGICS (Multi-national Alliant Gastro-Intestinal Cancer Symposium) 2015, Seoul, South Korea. 2015.
Yau T.C.C., The Budding of Early Phase Oncology Drug Development Program in Asia: The University of Hong Kong Experiences, Princess Margaret Hospital, University of Toronto, Toronto, Canada. 2015.
Yau T.C.C., The Treatment Algorithm for Refractory Colorectal Cancer, Bayer Singapore and Malaysia Regorafenib Advisory Board Meeting, Singapore. 2014.
Yau T.C.C., The Use of Chemotherapy in Pregnancy, Maternal Fetal Medicine Postgraduate Meeting, Queen Elizabeth Hospital, Hong Kong. 2014.
Yau T.C.C., The modern management of treatment refractory advanced colorectal cancer patients – The Asian Perspective, CME meeting, Department of Oncology, University of Malaya, Kuala Lumpur, Malaysia. 2014.


Researcher : Ye D
Project Title:Role of lipocalin-2 in nonalcoholic fatty liver disease
Investigator(s):Ye D, Wang Y
Department:Pharmacology & Pharmacy
Source(s) of Funding:Small Project Funding
Start Date:06/2013
Completion Date:11/2014


Project Title:Lipocalin-2 in acute and chronic liver diseases: focusing on neutrophil-mediated innate immune responses
Investigator(s):Ye D, Wang Y, Wong ICK
Department:Pharmacology & Pharmacy
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:10/2013


Project Title:Gut Microbiota Modulation of Host Physiology: The Search for Mechanism (C1); Neutrophil-derived Lipocalin-2 Mediates Nonalcoholic Steatohepatitis through Modulating Crosstalk between Mucosa Immunity and Gut Microbiota
Investigator(s):Ye D
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:03/2015


List of Research Outputs

KWOK H.M., Cheng K.Y., Li F.Y.L., Chan Y.C.C., Hoo R.L.C., Ye D., Xu A. and Lam K.S.L., Inactivation of c-Jun N-terminal Kinase in Adipose Tissue Alleviates Atherosclerosis in Diet-induced Obese ApoE-deficient Mice, 83rd European Atherosclerosis Society Congress. 2015.
Lin Z., Pan X., Wu F., Ye D., Zhang Y., Wang Y., Jin L., Lian Q., Huang Y., Ding H., Triggle C., Wang K., Li X. and Xu A., Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice, Circulation. 2015, 131(21): 1861-1871.
WANG Y., Xiao Y., ZHONG L., Ye D., Zhang J., Tu Y., Bornstein S.R., Zhou Z., Lam K.S.L. and Xu A., Increased Neutrophil Elastase and Proteinase 3 and Augmented NETosis Are Closely Associated With  -Cell Autoimmunity in Patients With Type 1 Diabetes, Diabetes. 2014, 63: 4239-4248.
Ye D., Wang Y., Li H., Jia W., Man K., Lo C.M., Wang Y., Lam K.S.L. and Xu A., Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1α-mediated antioxidant capacity in mice, Hepatology. 2014, 60: 977-989.


Researcher : Yeung CK
Project Title:HLA-B* 58:01 allele screening to reduce allopurinol-induced severe cutaneous reactions in patients with chronic kidney disease in Hong Kong
Investigator(s):Yeung CK, Tang SCW, Cheung BMY
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2012


List of Research Outputs

Chan C.Y.J., Shek S.Y.N., Yeung C.K. and Chan H.H.L., Clinical Efficacy and safety of a novel 755-nm picosecond laser in treatment of pigmentary lesions in Asians, The World Congress of Dermatology 2015 (Vancouver, Canada). 2015.
Chan C.Y.J., Yeung C.K., Shek S.Y.N. and Chan H.H.L., Featured Poster Award, The World Congress of Dermatology 2015 (Vancouver, Canada). 2015.
Chan H.H.L., Yeung C.K. and Shek S.Y.N., Featured Poster Award, The World Congress of Dermatology (2015); Vancouver, Canada.. 2015.
SING C.W., Cheung C.L., Wong I.C.K., Cheung B.M.Y., Yeung C.K., Chan H.H.L. and Chan C.Y.J., Toxic Epidermal Necrolysis: Clinical profile, aetiology and treatment in a tertiary hospital over a 16-year period. , Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and the British Pharmacological Society (BPS) Joint Scientific Meeting. 2015.
Shek S.Y.N., Chan C.Y.J., Yeung C.K. and Chan H.H.L., Clinical efficacy and safety of a novel dual wavelength 532/1064-nm picosecond laser in treatment of pigmentary lesions in Asians, The World Congress of Dermatology 2015 (Vancouver, Canada). 2015.
Shek S.Y.N., Yeung C.K., Chan P.Y.N., Chan C.Y.J. and Chan H.H.L., Evaluating the safety and efficacy of the 1,440-nm laser in the treatment of photodamage in Asian skin., In: Wiley, Lasers in Surgery and Medicine . Wiley Online Library, 2014, 46: 375-9.
Shek S.Y.N., Yeung C.K. and Chan H.H.L., Featured Poster Award, The World Congress of Dermatology 2015 (Vancouver, Canada). 2015.
Shek S.Y.N., Chan C.Y.J., Yeung C.K. and Chan H.H.L., THE EFFICACY OF A SECOND GENERATION FOCUSED ULTRASOUND COMBINED WITH RADIOFREQUENCY FOR BODY CONTOURING IN CHINESE, The World Congress of Dermatology 2015 (Vancouver, Canada). 2015.


Researcher : Yeung CY
List of Research Outputs

Cheung Y.Y., Hui Y.L.E., Cheung B.M.Y., Woo Y.C., Xu A., Fong H.Y., Ong K.L., Yeung C.Y., Janus E.D., Tse H.F., Sham P.C. and Lam K.S.L., Adiponectin gene variants and the risk of coronary heart disease: a 16-year longitudinal study., Eur J Endocrinol. 2014, 171: 107-115.
Ho C.W., Ho M.H., Chan P.H.M., Hai S.H.J.J., Cheung E., Yeung C.Y., Lau G.K.K., Chan K.H., Lau C.P., Lip G.Y., Leung G.K.K., Tse H.F. and Siu D.C.W., Ischemic stroke and intracranial hemorrhage with aspirin, dabigatran, and warfarin: impact of quality of anticoagulation control, Stroke. 2015.
Hui Y.L.E., Yeung C.Y., Lee P.C.H., Woo Y.C., Fong H.Y., Chow W.S., Xu A. and Lam K.S.L., Elevated Circulating Pigment Epithelium-Derived Factor Predicts the Progression of Diabetic Nephropathy in Patients With Type 2 Diabetes, The Journal of Clinical Endocrinology & Metabolism. 2014, 99: E2169-E2177.
Lee C.H.P., Hui Y.L.E., Woo Y.C., Yeung C.Y., Chow W.S., Yuen M.A.M., Fong H.Y., Xu A. and Lam K.S.L., Circulating Fibroblast Growth Factor 21 Levels Predict Progressive Kidney Disease in Subjects With Type 2 Diabetes and Normoalbuminuria, The Journal of Clinical Endocrinology & Metabolism. 2015, 100: 1368-1375.
Lee C.H.P., Woo Y.C., Wang Y., Yeung C.Y., Xu A. and Lam K.S.L., Obesity, adipokines and cancer: an update, Clinical Endocrinology. 2014, 83(2): 147-156.
Woo Y.C., Cheung B.M.Y., Yeung C.Y., Lee C.H.P., Hui Y.L.E., Fong H.Y., Tso A.W.K., Tam S. and Lam K.S.L., Cardiometabolic risk profile of participants with prediabetes diagnosed by HbA1c criteria in an urban Hong Kong Chinese population over 40 years of age , Diabetic Medicine. 2015, n/a-n/a.


Researcher : Yeung SC
List of Research Outputs

LIANG Y., LI X., Zhang Y., ZHEN Z., Yeung S.C., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Amelioration of cigarette smoke-induced cardiac dysfunction and inflammation by mesenchymal stem cells, J HK Coll Cardiol. 2014, 22: 49.
LIANG Y., LI X., Zhang Y., ZHEN Z., Yeung S.C., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Outstanding Oral presentation - Amelioration of cigarette smoke-induced cardiac dysfunction and inflammation by mesenchymal stem cells , 18th Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine. 2014.
Li X., Zhang Y., Yeung S.C., Liang Y., Li X., Ding Y., Ip M.S.M., Tse H.F., Mak J.C.W. and Lian Q., Mitochondrial transfer of induced pluripotent stem cells-derived MSCs to airway epithelial cells attenuates cigarette smoke-induced damage, American Journal of Respiratory Cell and Molecular Biology. 2014, 51(3): 455-465.
WANG Y., Yeung S.C., Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Intermittent hypoxia accelerates adipogenic differentiation in human subcutaneous preadipocytes in vitro, Am J Respir Crit Care Med. 2015, 191: A2704.


Researcher : Yim ASY
List of Research Outputs

Cheung K.F., Yung S.S.Y., Yim A.S.Y., Chau K.M., Yap Y.H.D. and Chan D.T.M., Annexin II-binding IgG and IgM in sera of patients with lupus nephritis, 3rd International Conference on Immune Tolerance 2014.
Yung S.S.Y., Lui S.L., Ng K.F., Yim A.S.Y., Ma K.M.M., Lo W.K., Chow C.C., Chu K.H., Chak W.L., Lam M.F., Yung C.Y., Yip T.P.S., Wong S., Tang S.O.C., Ng F.S.K. and Chan D.T.M., Impact of a Low-Glucose Peritoneal Dialysis Regimen on Fibrosis and Inflammation Biomarkers, Peritoneal Dialysis International. 2015, 35: 147-158.


Researcher : Yim RLH
List of Research Outputs

Yim R.L.H., Lee T.Y., Bow H.Y.C., Meij B., Leung V.Y.L., Cheung K.M.C., Vavken P. and Samartzis D., A systematic review of the safety and efficacy of mesenchymal stem cells for disc degeneration: new insights and future directions for regenerative therapeutics, Stem Cells Dev. 2014, 23: 2553-2567.


Researcher : Yip TPS
List of Research Outputs

Shea Y.F., Lam M.F., Lee M.S., Mok T.M.Y., Lui S.L., Yip T.P.S., Lo W.K., Chu L.W. and Chan D.T.M., Prevalence of CMMSE defined cognitive impairment among peritoneal dialysis patients and its impact on peritonitis, Clinical And Experimental Nephrology. 2015, 21 May 2015: Epub ahead of print.
Yung S.S.Y., Lui S.L., Ng K.F., Yim A.S.Y., Ma K.M.M., Lo W.K., Chow C.C., Chu K.H., Chak W.L., Lam M.F., Yung C.Y., Yip T.P.S., Wong S., Tang S.O.C., Ng F.S.K. and Chan D.T.M., Impact of a Low-Glucose Peritoneal Dialysis Regimen on Fibrosis and Inflammation Biomarkers, Peritoneal Dialysis International. 2015, 35: 147-158.


Researcher : Yiu KH
Project Title:Mechanism and Reversibility of Myocardial Fibrosis in Patients with Diabetic Cardiomyopathy: Role of Aliskiren.
Investigator(s):Yiu KH, Lam KSL, Tse HF, Wang MM
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2012


Project Title:Relationship between matrix G1a protein and osteogenic endothelial progenitor cells with vascular and valvular calcification in patients with rheumatoid arthritis: Potential therapeutic role of vitamin K
Investigator(s):Yiu KH, Lau WCS, Tse HF
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2013


List of Research Outputs

Chan Y.H., Yiu K.H., Lau G.K.K., Yiu Y.F., Li S.W., Lam T.H., Lau C.P., Siu C.W. and Tse H.F., The CHADS2 and CHA2DS2-VASc scores predict adverse vascular function, ischemic stroke and cardiovascular death in high-risk patients without atrial fibrillation: Role of incorporating PR prolongation, Atherosclerosis. 2014, 237(2): 504-13.
Chan Y.H., Lau K.K., Yiu K.H., Li L.S.W., Tam S., Lam T.H., Lau C.P., Siu D.C.W., Cheung B.M.Y. and Tse H.F., Vascular protective effects of statin-related increase in serum 25-hydroxyvitamin D among high-risk cardiac patients, Journal of Cardiovascular Medicine. 2015, 16: 51-58.
Chan Y.H., Lau G.K.K., Yiu K.H., Li L.S.W., Tam S., Lam T.H., Lau C.P., Siu D.C.W., Cheung B.M.Y. and Tse H.F., Vascular protective effects of statin-related increase in serum 25-hydroxyvitamin D among high-risk cardiac patients, Journal of Cardiovascular Medicine (Hagerstown). 2015.
Chen Y., Chung H.Y., Zhao C.T., Wong A., Zhen S., Tsang H.H., Lau W.C.S., Tse H.F. and Yiu K.H., Left ventricular myocardial dysfunction and premature atherosclerosis in patients with axial spondyloarthritis, Rheumatology. 2015, 54: 292-301.
Jim M.H., Wong K.L. and Yiu K.H., Angiographic and clinical results of everolimus-eluting stent utilization in saphenous vein graft lesions (ARES)., Int J Cardiol. 2015. 2015, 184: 433-435.
Jim M.H. and Yiu K.H., Combined drug-eluting stent and supplementary paclitaxel-eluting balloon application at side branch ostium for in-stent restenotic true bifurcation lesion., Int J Cardiol.. 2015, 181: 149-151.
Jim M.H., Lee M.K., Fung R.C., Chan A.K., Chan K.T. and Yiu K.H., Six month angiographic result of supplementary paclitaxel-eluting balloon deployment to treat side branch ostium narrowing (SARPEDON)., Int J Cardiol. 2015. 2015, 187: 594-597.
Luo T., Yue R., Hu H., Zhou Z., Yiu K.H., Zhang S., Xu L., Li K. and Yu Z., PD150606 protects against ischemia/reperfusion injury by preventing μ-calpain-induced mitochondrial apoptosis., Arch Biochem Biophys. 2015.
Santoso T., Siu D.C.W., Irawan C., Chan W.S., Alwi I., Yiu K.H., Aziz A., Kwong Y.L. and Tse H.F., Endomyocardial Implantation of Autologous Bone Marrow Mononuclear Cells in Advanced Ischemic Heart Failure: a Randomized Placebo-Controlled Trial (END-HF)., J Cardiovasc Transl Res. 2014.
Tse H.F., Turner S., Sanders P., Okuyama Y., Fujiu K., Cheng C.W., Russo M., Green M.D., Yiu K.H., Chen P., Shunto C., Lau E.O. and Siu D.C.W., Thoracic Spinal Cord Stimulation for Heart Failure as a Restorative Treatment (SCS HEART study): first-in-man experience, Heart Rhythm. 2015, 12(3): 588-595.
WONG C.K.A., CHEN Y., HO L.M., ZHEN Z., Siu D.C.W., Tse H.F. and Yiu K.H., Angiographic result of T-stenting with small protrusion using drug-eluting stents in the management of ischemic side branch: the ARTEMIS study., Nutr Metab Cardiovasc Disorder 2014. 2014.
Yiu K.H., 23. Invited Speaker, Associacao dos Medicos de Clinica Geral de Macau Chronic Disease CME 2015, “Optimizing Lipid Management in Cardiovascular Disease: even lower is even better”, 2015.
Yiu K.H., Chairperson,”17th South China International Congress of Cardiology, “Symposium of Cardiovascular Diagnosis”, 2015.
Yiu K.H., Ng W.S., Chan D., Sit K.Y., Wong A., Lee C.W., Chum H.L., Cheung W.Y., Pun C.T., Ho K.L., CHEN Y., Ho K.M., Kumana C.R., Cheung H.L., Chung M.C., Lau C.P., Au K.W. and Tse H.F., Improved prognosis following renin-angiotensin-aldosterone system blockade in patients undergoing concomitant aortic and mitral valve replacement., Int J Cardiol. 2014. 2014, 177(2): 680-682.
Yiu K.H., Invited Speaker, APHRS Physician Education Program 2015, “ Heart Failure and basics of CRT”, 2015.
Yiu K.H., Invited Speaker, CardioRhythm 2015, “ Role of echo to guide LV Lead placement,”, “ Role of MRI for CRT”, “ A sleep apnea patient with cardiomegaly,”” How to deal with a patient on novel anticoagulant when they develop other medical issues?, 2015.
Yiu K.H., Invited Speaker, Cardiovascular Vascular scientific Seminar for Kiang Wu Hospital Medical Seminar, Macau” Cardio-protection along CV Continuum”, 2015.
Yiu K.H., Invited Speaker, Hong Kong Baptist Hospital, “ From Latest Guidelines to Treatment Practise- Update of Hyperlipidemia Management, 2015.
Yiu K.H., Invited Speaker, Macau Physician Society Symposium, “ A new Paradigm for the Treatment of VTE”, 2015.
Yiu K.H., Invited Speaker, St Paul Hospital 2015, “ Advance in Medications for Type 2 Diabetes and Dyslipidemia Management,” Optimizing Lipid Management in Cardiovascular Disease: Even Lower is Even Better”, 2015.
Yiu K.H., Invited Speaker, The Continuing Medical Education (CME) in Wuchan, “ NOAC Real World Experiences,”, 2015.
Yiu K.H., Invited Speaker, University of Hong Kong Department of Microbiology,” Infectious Disease Courses and Postgraduate Diploma Programme, “Cardiologist tricks in diagnosing heart infections”, 2015.
Yiu K.H., Invited Speaker, 東莞心律失常治療專家研討會 2014, 2014.


Researcher : Yiu WH
Project Title:ASN Kidney Week 2013 Annual Meeting ; Tissue Kallikrein Mediates Pro-inflammatory Pathways in Proximal Tubular Epithelial Cells
Investigator(s):Yiu WH
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:11/2013


Project Title:The role of coagulation system in renal fibrosis
Investigator(s):Yiu WH, Tang SCW
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:01/2014


List of Research Outputs

LI R., Yiu W.H., Wu H., LIN M., WONG W.L.D., Chan Y.Y., Leung J.C.K., Lai K.N. and Tang S.C.W., BMP7 Reduces Tubular Inflammation and Oxidative Stress in Diabetic Nephropathy, J Am Soc Nephrol. 2014, 25: 216A.
LI R., Yiu W.H., Wu H., WONG W.L.D., Chan Y.Y., LIN M., Leung J.C.K., Lai K.N. and Tang S.C.W., BMP7 reduces inflammation and oxidative stress in diabetic tubulopathy, Clinical Science [IF 5.629]. 2015, 128(4): 269-280.
LI R., Yiu W.H. and Tang S.C.W., Role of bone morphogenetic protein-7 in renal fibrosis, Frontiers Physiology [IF 3.534]. 2015, 6: 114.
Tang S.C.W., Yiu W.H., LIN M. and Lai K.N., Diabetic Nephropathy and Proximal Damage, Journal of Renal Nutrition [IF 2.548]. 2015, 25(2): 230-233.
Yiu W.H., WONG W.L.D., Leung J.C.K., Chan Y.Y., Lai K.N. and Tang S.C.W., Thrombin Induces Epithelial-Mesenchymal Transition Through the Activation of PAR-1 in Tubular Epithelial Cells, J Am Soc Nephrol. 2014, 25: 730A.
Yiu W.H., LIN M. and Tang S.C.W., Toll-like receptor activation: from renal inflammation to fibrosis, Kidney International Supplements. 2014, 4(1): 20-25.


Researcher : Young JLP
List of Research Outputs

Wong D.K.H., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Hung I.F.N., Young J.L.P., Yuen J.C.H., Ngai W.S., Yuen R.M.F. and Lai C.L., Reduction of hepatitis B core related antigen by long term nucleoside nucleotide analogue therapy and its correlation with intrahepatic HBV DNA reduction, 24th Annual Conference of APASL, March 12–15, 2015, Istanbul, Turkey. Hepatology International. 2015, 9 (Suppl 1): S202.


Researcher : Yuen JCH
List of Research Outputs

Hung I.F.N., Wong D.K.H., Poon R.T.P., Fong D.Y.T., Seto W.K.W., Fung J.Y.Y., Yuen J.C.H., Tiu T.M.R.J., Lai C.L. and Yuen R.M.F., Risk Factors and Post-resection Independent Predictive Score for the Recurrence of Hepatitis B-related Hepatocellular Carcinoma, 20th Medical Research Conference 2015, 17 Jan 2015, The University of Hong Kong, Hong Kong.. 2015.
Lai C.L., Wong D.K.H., Ip P.C.P., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lee B.P., Cullaro G., Wu C.H., Cheng C.T.K., Yuen J.C.H., Ngai W.S. and Yuen R.M.F., Profound Reduction of HBV Covalently Closed Circular DNA with Long-term Nucleoside/tide Analogue Therapy, Hepatology. 2014, 60, No. 4 (Suppl): 183A.
Wong D.K.H., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Hung I.F.N., Young J.L.P., Yuen J.C.H., Ngai W.S., Yuen R.M.F. and Lai C.L., Reduction of hepatitis B core related antigen by long term nucleoside nucleotide analogue therapy and its correlation with intrahepatic HBV DNA reduction, 24th Annual Conference of APASL, March 12–15, 2015, Istanbul, Turkey. Hepatology International. 2015, 9 (Suppl 1): S202.


Researcher : Yuen MAM
List of Research Outputs

Lee C.H.P., Hui Y.L.E., Woo Y.C., Yeung C.Y., Chow W.S., Yuen M.A.M., Fong H.Y., Xu A. and Lam K.S.L., Circulating Fibroblast Growth Factor 21 Levels Predict Progressive Kidney Disease in Subjects With Type 2 Diabetes and Normoalbuminuria, The Journal of Clinical Endocrinology & Metabolism. 2015, 100: 1368-1375.


Researcher : Yuen MF
Project Title:An open label study of adefovir dipivoxil for the treatment of patients with chronic hepatitis B (CHB) related advanced fibrosis or cirrhosis
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Glaxo Wellcome Hong Kong Ltd. - General Award
Start Date:07/2005


Project Title:Randomized, open-label, comparative study to evaluate early viral load reductions and exploratory viral kinetics following administration of entecavir or adefovir in nucleoside-naïve adults with chronic hepatitis B infection
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Bristol-Myers-Squibb (HK) - General Award
Start Date:01/2006


Project Title:A phase I, multi-centre, randomised, placebo-controlled, dose escalation study to assess the local and systemic tolerability of the therapeutic DNA plasmid pdpSC18 vaccine administered by particle mediated epidermal delivery using the powderject ND 10 delivery system in subjects with chronic hepatitis B infection
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:PowderMed Ltd - General Award
Start Date:11/2006


Project Title:Significance of HBV DNA in the natural history of chronic hepatitis B: impact on disease outcome including significant fibrosis and hepatocellular carcinoma
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Bristol-Myers-Squibb (HK) - General Award
Start Date:09/2007


Project Title:Outstanding Researcher Award 2009-10
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Outstanding Researcher Award
Start Date:12/2010


List of Research Outputs



Researcher : Yuen RMF
Project Title:An open label study of adefovir dipivoxil for the treatment of patients with chronic hepatitis B (CHB) related advanced fibrosis or cirrhosis
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Glaxo Wellcome Hong Kong Ltd. - General Award
Start Date:07/2005


Project Title:Randomized, open-label, comparative study to evaluate early viral load reductions and exploratory viral kinetics following administration of entecavir or adefovir in nucleoside-naïve adults with chronic hepatitis B infection
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Bristol-Myers-Squibb (HK) - General Award
Start Date:01/2006


Project Title:A phase I, multi-centre, randomised, placebo-controlled, dose escalation study to assess the local and systemic tolerability of the therapeutic DNA plasmid pdpSC18 vaccine administered by particle mediated epidermal delivery using the powderject ND 10 delivery system in subjects with chronic hepatitis B infection
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:PowderMed Ltd - General Award
Start Date:11/2006


Project Title:Significance of HBV DNA in the natural history of chronic hepatitis B: impact on disease outcome including significant fibrosis and hepatocellular carcinoma
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Bristol-Myers-Squibb (HK) - General Award
Start Date:09/2007


Project Title:Outstanding Researcher Award 2009-10
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Outstanding Researcher Award
Start Date:12/2010


List of Research Outputs

Chan H.L.Y., Kadayifci A., Papatheodoridis G., Yuen R.M.F., Chien R.N., Kwan W.C.P., Lin L., Dinh P., Martins E.B., Charuworn P., Subramanian G.M., Mchutchison J.G., Petersen J., Shiffman M., Reesink H.W., Lim S.G., Lim Y.S. and Marcellin P., Characterization of HBsAg decline in the Tenofovir disoproxil fumarate (TDF) and peginterferon alfa 2A (PEG) combination study for chronic hepatitis B (CHB), 24th Annual Conference of APASL, March 12-15, 2015, Istanbul, Turkey. Hepatology International. 2015, 9 (Suppl 1): S39.
Chan V.N.Y., Lai C.L., Chan K. and Yuen R.M.F., Hepatitis B virus array for genotyping and mutation detection, Hong Kong Medical Journal. 2014, 20(6): Suppl 6: 25-7.
Choudhury A., Sarin S.K., Kumar K.N.C., Vashishtha C., Abbas Z., Amarpurkar D., Butt A.S., Chan A.C.Y., Chawla Y.K., Dokmec A.K., Garg H., Ghazinyan H., Hamid S.S., Jia J.D., Kumar M., Lee G.H., Lesmana L., Mahtab M., Maiwa R., Moreau R., Ning Q., Pamecha V., Payawal D., Rahman S., Samuel D., Shah S., Shiha G., Sharma B.C., Tan S.S., Yuen R.M.F., Yokosuka O., Devarbhabi H.C., Eapen C.E. and Apasl Aclf Working Party , Defining a ‘golden window’ period and relevance of systemic inflammatory response syndrome (SIRS) in acute on chronic liver failure (ACLF) a tool for intervention and improved survival, 24th Annual Conference of APASL, March 12–15, 2015, Istanbul, Turkey. Hepatology International. 2015, 9 (Suppl 1): S4-5.
Fung J.Y.Y., Wong D.K.H., Seto W.K.W., Kopaniszen M., Lai C.L. and Yuen R.M.F., Hepatitis B Surface Antigen Seroclearance: Relationship to Hepatitis B e-Antigen Seroclearance and Hepatitis B e-Antigen-Negative Hepatitis, The American Journal of Gastroenterology. 2014, 109: 1764-1770.
Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Management of chronic hepatitis B in severe liver disease, World Journal of Gastroenterology. 2014, 20(43): 16053–61.
Fung J.Y.Y., Lam Y.F., Chok K.S.H., Seto W.K.W., Wong C.L.T., Chan A.C.Y., Chan S.C., Lai C.L., Lo C.M. and Yuen R.M.F., Modified model for end stage liver disease score accurately predicts death or liver transplantation in acute flares of chronic hepatitis B, Poster presentaion at the International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2015, 62(Suppl 2): S537.
Gish R.G., Yuen R.M.F., Chan H.L.Y., Given B.D., Lai C.L., Locarnini S.A., Lau J.Y.N., Wooddell C.I., Schluep T. and Lewis D.L., Synthetic RNAi triggers and their use in chronic hepatitis B therapies with curative intent, Antiviral Research. 2015, 121: 97-108.
Hsu A.S.J. and Yuen R.M.F., Malabsorption disorders, In: Hasan M, Akbar SMF, Mantab MA , Textbook of Hepato-Gastroenterology. Jaypee Brothers Medical Publishers (P) Ltd, 2015, Chapter 7: 61-7.
Huang F.Y., Wong D.K.H., Seto W.K.W., Lai C.L. and Yuen R.M.F., Estradiol activated microrna 23a directly or synergistically with p53 implicated in sex difference in hepatocellular carcinoma development, 24th Annual Conference of APASL, March 12–15, 2015, Istanbul, Turkey. Hepatology International. 2015, 9 (Suppl 1): S137-8.
Hung I.F.N., Wong D.K.H., Poon R.T.P., Fong D.Y.T., Seto W.K.W., Fung J.Y.Y., Yuen J.C.H., Tiu T.M.R.J., Lai C.L. and Yuen R.M.F., Risk Factors and Post-resection Independent Predictive Score for the Recurrence of Hepatitis B-related Hepatocellular Carcinoma, 20th Medical Research Conference 2015, 17 Jan 2015, The University of Hong Kong, Hong Kong.. 2015.
Lai C.L. and Yuen R.M.F., Management of Chronic Hepatitis B in Patients from Special Populations, Cold Spring Harbor Perspectives in Medicine. 2015, 5: a021527-a021527.
Lai C.L. and Yuen R.M.F., Management of patients from special populations, In: Seeger C and Locarnini S, Hepatitis B and Delta viruses. Cold Spring Laboratory Press, 2015, 274-288.
Lai C.L., Wong D.K.H., Ip P.C.P., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Lee B.P., Cullaro G., Wu C.H., Cheng C.T.K., Yuen J.C.H., Ngai W.S. and Yuen R.M.F., Profound Reduction of HBV Covalently Closed Circular DNA with Long-term Nucleoside/tide Analogue Therapy, Hepatology. 2014, 60, No. 4 (Suppl): 183A.
Lai C.L., Yuen R.M.F., Yang J.C., Knox S.J., Mo H.M., Han L.L., Brainard D.M., Mchutchison J.G., Wong V.W.S. and Chan H.L.Y., Sofosbuvir plus ribavirin for 12 16 or 24 weeks results in sustained virologic response over 97 % in genotype 1 and 6 HCV infection in Hong Kong, 24th Annual Conference of APASL, March 12–15, 2015, Istanbul, Turkey. Hepatology International. 2015, 9 (Suppl 1): S58.
Lam Y.F., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Continuous entecavir for treatment naı¨ve chinese chronic hepatitis B patients in the real world setting the seven year results, 24th Annual Conference of APASL, March 12–15, 2015, Istanbul, Turkey. Hepatology International. 2015, 9 (Suppl 1): S204-5.
Sarin S.K., Kedarisetty C.K., Abbas Z., Amarapurkar D., Bihari C., Chan A.C.Y., Chawla Y.K., Dokmeci A.K., Garg H., Ghazinyan H., Hamid S., Kim D.J., Komolmit P., Lata S., Lee G.H., Lesmana L.A., Mahtab M., Maiwall R., Moreau R., Ning Q., Pamecha V., Payawal D.A., Rastogi A., Rahman S., Rela M., Saraya A., Samuel D., Saraswat V., Shah S., Shiha G., Sharma B.C., Sharma M.K., Sharma K., Butt A.S., Tan S.S., Vashishtha C., Wani Z.A., Yuen R.M.F., Yokosuka O. and APASL ACLF Working Party , Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) 2014, Hepatology International. 2014, 8(4): 453-71.
Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Liu S.H.K., Singh G.H.H., Lam Y.F., Fung J.Y.Y., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., A prospective study of hepatitis B reactivation in patients with prior HBV exposure undergoing hematopoietic stem cell transplantation: Reactivation association with graft-versus-host disease, Oral presentation at the International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2015, 62(Suppl 2): S194.
Seto W.K.W., Lau E.H.Y., Wu J.T.K., Hung I.F.N., Leung W.K., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., An epidemiological association between the trends of nucleoside analogue prescription and liver cancer incidence from 1999 to 2012 in Hong Kong, China, Poster presentation at the International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2015, 62(Suppl 2): S435.
Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Singh G.H.H., Lam Y.F., Lie A.K.W., Lai C.L., Kwong Y.L. and Yuen R.M.F., Hepatitis B reactivation in patients with prior HBV exposure undergoing rituximab-containing chemotherapy for lymphoma: a prospective study, Journal of Clinical Oncology. 2014, 32(33): 3736-43.
Seto W.K.W., Tanaka Y., Wong D.K.H., Shinkai N., Cheung K.S., Liu S.H.K., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Longitudinal serologic profiles up to 5 years in hepatitis B surface antigen-negative chronic hepatitis B, Hepatology. 2014, 60, No. 4 (Suppl): 57A.
Tan V.P.Y., Wong B.C.Y., Wong R.W.M., Leung W.K., Tong D.K.H., Yuen R.M.F. and Fass R., Gastroesophageal reflux disease: cross-sectional study demonstrating rising prevalence in a Chinese population, J Clin Gastroenterol. 2015, Epub ahead of print.
Tan V.P.Y., Liu S.H.K., Lam Y.F., Hung I.F.N., Yuen R.M.F. and Leung W.K., Rifaximin for the Treatment of Functional Dyspepsia: A Double-Blind Randomized Placebo-Controlled Trial., Digestive Diseases Week 2015.
Wong D.K.H., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Zhang J., Hung I.F.N., Lai C.L. and Yuen R.M.F., Identification of Hepatitis B Virus DNA Polymerase Sequences to Predict Virological Response to Entecavir Therapy, Health Research Symposium 2014, Hong Kong, 15 Nov 2014. (Poster presentation). 2014.
Wong D.K.H., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Identification of hepatitis B virus DNA reverse transcriptase variants associated with partial response to entecavir, Hong Kong Medical Journal. 2015, 21(Suppl 4): 35-8.
Wong D.K.H., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Hung I.F.N., Young J.L.P., Yuen J.C.H., Ngai W.S., Yuen R.M.F. and Lai C.L., Reduction of hepatitis B core related antigen by long term nucleoside nucleotide analogue therapy and its correlation with intrahepatic HBV DNA reduction, 24th Annual Conference of APASL, March 12–15, 2015, Istanbul, Turkey. Hepatology International. 2015, 9 (Suppl 1): S202.
Yuen R.M.F., Advisor, The Journal of the Royal College of Physicians of Edinburgh. 2014.
Yuen R.M.F., Antiviral therapy in acute on chronic liver failure due to hepatitis B reactivation, The 2nd Central China International Forum on Liver Disease and Infection & National Continuous Medical Education Program 2014 on Progress of Diagnosis and Treatment on Infectious Diseases, Wuhan, China, September, 19 – 21. 2014.
Yuen R.M.F., Antiviral treatment for severe HBV reactivation, Taiwan Digestive Disease Week, Kaohsiung, Taiwan, 5th October 2014. 2014.
Yuen R.M.F., Antiviral treatment for severe HBV reactivation, Taiwan Digestive Disease Week, Kaosiung, Taiwan, October 5. 2014.
Yuen R.M.F., Clinical implication of occult hepatitis B infection: Introduction., 2nd International Conference on Occult HBV Infection, Guangzhou, China, 10– 11th October 2014. 2014.
Yuen R.M.F., Clinical utility of HBsAg quantitative assay, The 1st Asian Workshop for Hepatitis B Virus Markers, Istanbul Turkey, 14 March 2015. 2015.
Yuen R.M.F., Editor, Hepatitis Research and Treatment. Hindawi Publishing Corporation, 2015.
Yuen R.M.F., Editor, Internal Medicine. 2015.
Yuen R.M.F., Editor, Journal of Clinical and Translational Hepatology. 2014.
Yuen R.M.F., Editor, Journal of Gastroenterology and Hepatology. 2014.
Yuen R.M.F., Editorial Board Member, Gut and Liver. 2014.
Yuen R.M.F., Editorial Board Member, Korean Journal of Hepatology. 2014.
Yuen R.M.F., Editorial Board Member, World Journal of Biological Chemistry. 2014.
Yuen R.M.F., Editorial Board Member, World Journal of Gastroenterology. 2014.
Yuen R.M.F., Editorial Board Member, World Journal of Hepatology. Elsevier, 2015.
Yuen R.M.F., Eltrombopag for the treatment of HCV associated thrombocytopenia: New indication, Hong Kong, July 10. 2014.
Yuen R.M.F. and Lai C.L., Hepatitis B in 2014: HBV research moves forward—receptors and reactivation, Nature Reviews Gastroenterology & Hepatology. 2014, 12: 70-72.
Yuen R.M.F., Hepatitis B management: current and future: an Asia Pacific Perspective, Continued Education Programme, Kolkata, Hyderabad, Mumbai and Delhi, India, August 28 – 31. 2014.
Yuen R.M.F., Hepatitis B reactivation, Asia Pacific B Cell Malignancies Standalone Meeting, Seoul, South Korea, 22nd – 23rd November 2014. 2014.
Yuen R.M.F., Hepatitis B virus infection in all aspects: occult hepatitis B and immunotolerarnce, The 24th Conference of Asian-Pacific Association for the Study of the Liver (APASL), Istanbul, Turkey, 12-15 March 2015. 2015.
Yuen R.M.F., Hepatology International , 2014.
Yuen R.M.F., Long-term outcome of continuous NUCs treatment in real-world setting, Taiwan Digestive Disease Week, Kaohsiung, Taiwan 5th October 2014. 2014.
Yuen R.M.F., Member of Review Team, Hepatitis B. World Gastroenterology Organization Practice Guideline, Version 1.82 January 2015. 2015.
Yuen R.M.F., Occult hepatitis B infection: why, who and what to do?, State-of-the-Art Lecture at the 27th Annual Scientific Meeting, International Symposium on Hepatology 2014, 16th November 2014. 2014.
Yuen R.M.F., Occult hepatitis B virus, Plenary session, Asian Oncology Summit & Viral Hepatitis 2015, Shanghai, China, 10-12th April 2015. 2015.
Yuen R.M.F., Occult hepatitis B virus, The 4th Annual Asia Hepatology Perspective Forum, Taipei, Taiwan, 6– 7th December 2014. 2014.
Yuen R.M.F., Revisiting the stopping rule of guideline recommendation for nucleotide-treated patients, The 4th HBV single topic conference, Asian Pacific Association for the Study of the Liver, Guangzhou, China, 12th-14th December 2014. 2014.
Yuen R.M.F., The challenges of chronic HCV management, AbbVie Hepatitis C Drug Launch Symposium, Macau, 23 March 2015. 2015.
Yuen R.M.F., The significance of HBsAg level in the clinical management of HBV infection, Infectious Disease Courses and Postgraduate Diploma Programme, Department of Microbiology, The University of Hong Kong, July 12. 2014.
Yuen R.M.F., The significance of HBsAg level in the clinical management of HBV infection, Infectious Disease Courses and Postgraduate Diploma Programme, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong. 2014.
Yuen R.M.F., Ahn S.H., Lee K.S., Um S.H., Cho M., Yoon S.K., Lee J.W., Park N.H., Kweon Y.O. and Sohn J.H., Two-year treatment outcome of chronic hepatitis B infection treated with besifovir vs. entecavir: Results from a multicentre study, Journal of Hepatology. 2015, 62: 526-532.
Yuen R.M.F., World Journal of Gastroenterology Pharmacology and Therapeutics. Elsevier, 2015.
ZHANG A., Wong D.K.H., Huang F.Y., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Evolutionary changes of hepatitis B virus pre-S mutations prior to development of hepatocellular carcinoma, Poster presentation at the International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2015, 62(Suppl 2): S543.


Researcher : Yung SSY
Project Title:The Role of Fibronectin in Peritoneal Inflammation and Fibrosis
Investigator(s):Yung SSY, Chan DTM
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2013


Project Title:The role of microRNAs in fibrogenic processes in mesothelial cells
Investigator(s):Yung SSY, Chan DTM
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2013


Project Title:The role of hyaluronan in peritoneal inflammation and fibrosis
Investigator(s):Yung SSY, Chan DTM
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2014


Project Title:Kidney Week 2014; Decorin Ameliorates Peritoneal Fibrosis in Peritoneal Dialysis Related Peritonitis
Investigator(s):Yung SSY
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:11/2014
Completion Date:11/2014


Project Title:Fibronectin fragments and isoforms in the pathogenesis of tubulo-interstitial damage in lupus nephritis
Investigator(s):Yung SSY, Chan DTM
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2015


Project Title:Changes in miR-200a and miR-200b expression in mesothelial cells with time on peritoneal dialysis
Investigator(s):Yung SSY, Chan DTM
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2015


List of Research Outputs

Chan D.T.M., Au K.Y., MA X., Tse W.W., Chau K.M. and Yung S.S.Y., CD44 expression in serum and kidney correlates with disease activity in lupus nephritis, 52nd European Renal Association/European Dialysis Transplantation Association Congress. 2015.
Chan D.T.M., Tse W.W., Chau K.M. and Yung S.S.Y., Increased Synthesis of CD44s and its Variants in Kidney Fibrosis of Lupus Nephritis, American Society of Nephrology Kidney Week 2014.
Chan D.T.M., Au K.Y., MA X., Tse W.W., Chau K.M. and Yung S.S.Y., Serum and renal expression of CD44s and its variants correlate with disease activity in lupus nephritis, World Congress of Nephrology 2015.
Cheung K.F., Yung S.S.Y., Yim A.S.Y., Chau K.M., Yap Y.H.D. and Chan D.T.M., Annexin II-binding IgG and IgM in sera of patients with lupus nephritis, 3rd International Conference on Immune Tolerance 2014.
Chu J.Y.S., Yung S.S.Y., Chau K.M., Kam K.M. and Chan D.T.M., MicroRNA-200c inhibits TGF-β1-induced epithelial-to-mesenchymal transition and fibrogenesis in mesothelial cells, Gordon Research Conference - Fibronectin, Integrins & Related Molecules. 2015.
Ip K.M., Yung S.S.Y., Chan D.T.M., Tsao G.S.W. and Wong A.S.T., p70 S6 kinase drives ovarian cancer metastasis through multicellular spheroid-peritoneum interaction and P-cadherin/beta1 integrin signaling activation, Oncotarget. 2014, 5: 9133-9149.
JIANG N., Yung S.S.Y., Chau K.M., Zhang Q. and Chan D.T.M., Decorin Suppresses Mesothelial Cell Epithelial-to-Mesenchymal Transition, 15th Congress of the International Society for Peritoneal Dialysis. 2014.
LI N., Chau K.M., Kam K.M., Chan D.T.M. and Yung S.S.Y., Peritonitis Induces Native and EDA+ Fibronectin Expression in Peritoneal Mesothelial Cells Via TGF-beta1 and PI3K and MAPK Activation, Gordon Research Conference Fibronectin, Integrins & Related Molecules. 2015.
Liu Y., Liao J., Zhao M., Wu H., Yung S.S.Y., Chan D.T.M., Yoshimura A. and Lu Q., Increased expression of TLR2 in CD4+ T cells from SLE patients enhances immune reactivity and promotes IL-17 expression through histone modifications , European Journal of Immunology. 2015, 45(9): 2683-2693.
Luo S., Liu Y., Liang G., Zhao M., Wu H., Liang Y., Qiu X., Tan Y., Dai Y., Yung S.S.Y., Chan D.T.M. and Lu Q., The role of microRNA-1246 in the regulation of B cell activation and the pathogenesis of systemic lupus erythematosus, Clinical Epigenetics. 2015, 7: 24.
Ngalamika O., Liang G., Zhao M., Yu X., Yang Y., Yin H., Liu Y., Yung S.S.Y., Chan D.T.M. and Lu Q., Peripheral whole blood FOXP3 TSDR methylation: a potential marker in severity assessment of autoimmune diseases and chronic infections, Immunol Invest. 2014, 44(2): 126-136 [Epub a Aug 2014].
Tsun J.G.S., Yung S.S.Y., Chau K.M., Shiu S.W.M., Chan D.T.M. and Tan K.C.B., Cellular cholesterol transport proteins in diabetic nephropathy, PLoS One. 2014, 9(9): e105787.
Yang Y., Tang Q., Zhao M., Liang G., Wu H., Li D., Xie Y., Tan Y., Dai Y., Yung S.S.Y., Chan D.T.M. and Lu Q., The effect of mycophenolic acid on epigenetic modifications in lupus CD4+ T cells, Clinical Immunology. 2015, 158: 67-76.
Yap Y.H.D., Yung S.S.Y., Zhang Q., Tang S.O.C. and Chan D.T.M., Mesangial cell-binding activity of serum immunoglobulin G in patients with lupus nephritis, PLoS One. 2014, 9(7): e101987.
Yung S.S.Y., Ng C.Y., Ho S.K., Cheung K.F., Chan K.W., Zhang Q., Chau K.M. and Chan D.T.M., Anti-dsDNA antibody induces soluble fibronectin secretion by proximal renal tubular epithelial cells and downstream increase of TGF-β1 and collagen synthesis, Journal of Autoimmunity. 2015, 58: 111-122.
Yung S.S.Y., JIANG N., Chau K.M., Zhang Q. and Chan D.T.M., Decorin Ameliorates Peritoneal Fibrosis in Peritoneal Dialysis Related Peritonitis, American Society of Nephrology Kidney Week 2014.
Yung S.S.Y., Lui S.L., Ng K.F., Yim A.S.Y., Ma K.M.M., Lo W.K., Chow C.C., Chu K.H., Chak W.L., Lam M.F., Yung C.Y., Yip T.P.S., Wong S., Tang S.O.C., Ng F.S.K. and Chan D.T.M., Impact of a Low-Glucose Peritoneal Dialysis Regimen on Fibrosis and Inflammation Biomarkers, Peritoneal Dialysis International. 2015, 35: 147-158.
Yung S.S.Y., Tse W.W., Chau K.M. and Chan D.T.M., Inhibition of Hyaluronan Synthesis in NZBWF1/J Mice Decreased Glomerular Deposition of Fibronectin and Collagen and Improved Renal Function, Gordon Research Conference Fibronectin, Integrins & Related Molecules. 2015.
Yung S.S.Y., The Role of Anti-dsDNA Antibodies in Tubulo-interstitial Injury of Lupus Nephritis, 2015 International Symposium on Epigenetics and Autoimmunity. 2015.
Zhao M., Liu S., Luo S., Wu H., Tang M., Cheng W., Zhang Q., Zhang P., Yu X., Xia Y., Yi N., Gao F., Wang L., Yung S.S.Y., Chan D.T.M., Sawalha A.H., Richardson B., Gershwin M.E., Li N. and Lu Q., DNA methylation and mRNA and microRNA expression of SLE CD4+ T cells correlate with disease phenotype, J Autoimmun. 2014, 54: 127-136 [Epub 3 Aug 2014].


Researcher : ZHANG A
List of Research Outputs

ZHANG A., Wong D.K.H., Huang F.Y., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Evolutionary changes of hepatitis B virus pre-S mutations prior to development of hepatocellular carcinoma, Poster presentation at the International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2015, 62(Suppl 2): S543.


Researcher : ZHANG M
List of Research Outputs

Fan J., Cheung R.T.F., Chu L.W., Fung P.C.W., Chang C.Q., Sik H.H., ZHANG M., XIE B. and Gao J., Reduced bilateral temporal Alpha-band EEG activity during resting state in older adults, International Conference on Digital Signal Processing. Hong Kong, 2014.
ZHANG M., XIE B., Mak H.K.F. and Cheung R.T.F., Cognitive impairments in patients with severe periventricular hyperintensities, Twentieth Medical Research Conference, Department of Medicine, The University of Hong Kong. 2015, 21 (Suppl 1): 59.


Researcher : ZHEN Z
List of Research Outputs

LIANG Y., LI X., Zhang Y., ZHEN Z., Yeung S.C., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Amelioration of cigarette smoke-induced cardiac dysfunction and inflammation by mesenchymal stem cells, J HK Coll Cardiol. 2014, 22: 49.
LIANG Y., LI X., Zhang Y., ZHEN Z., Yeung S.C., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Outstanding Oral presentation - Amelioration of cigarette smoke-induced cardiac dysfunction and inflammation by mesenchymal stem cells , 18th Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine. 2014.
WONG C.K.A., CHEN Y., HO L.M., ZHEN Z., Siu D.C.W., Tse H.F. and Yiu K.H., Angiographic result of T-stenting with small protrusion using drug-eluting stents in the management of ischemic side branch: the ARTEMIS study., Nutr Metab Cardiovasc Disorder 2014. 2014.


Researcher : ZHENG C
List of Research Outputs

LI Y., Lam S.K., ZHENG C., LEUNG L.L. and Ho J.C.M., The effect of tumor microenvironment on autophagy and sensitivity to targeted therapy in EGFR-mutated lung adenocarcinoma , 21st Hong Kong International Cancer Congress. 2014.
Lam S.K., LI Y., ZHENG C., LEUNG L.L. and Ho J.C.M., Combination Effect of Arsenic Trioxide and FGFR Inhibitor through Downregulation of FGFR, Akt and Erk in Squamous Cell Lung Carcinoma, 21st Hong Kong International Cancer Congress. 2014.
Lam S.K., LI Y., ZHENG C. and Ho J.C.M., Downregulation of Thymidylate Synthase and E2F1 by Arsenic Trioxide in Mesothelioma , Work Injury Prevention and Rehabilitation 2014.
Lam S.K., LI Y., ZHENG C. and Ho J.C.M., Downregulation of thymidylate synthase and E2F1 by arsenic trioxide in mesothelioma., International journal of oncology. 2014, 46: 113-22.
Lam S.K., LI Y., ZHENG C., LEUNG L.L. and Ho J.C.M., E2F1 Downregulation by Arsenic Trioxide in Lung Adenocarcinoma, International Journal of Oncology. 2014, 45: 2033-43.
Li Y.V., Lam S.K., Zheng C. and Ho J.C.M., The Effect of Tumor Microenvironment on Autophagy and Sensitivity to Targeted Therapy in EGFR-Mutated Lung Adenocarcinoma, Journal of Cancer. 2015, 6: 382-386.
ZHENG C., Lam S.K., LI Y., LEUNG L.L. and Ho J.C.M., Arsenic trioxide-induced cytotoxicity in small cell lung cancer via altered redox homeostasis and mitochondrial integrity , 21st Hong Kong International Cancer Congress. 2014.
ZHENG C., Lam S.K., LI Y. and Ho J.C.M., Arsenic trioxide-induced cytotoxicity in small cell lung cancer via altered redox homeostasis and mitochondrial integrity., International journal of oncology. 2014, 46: 1067-1078.


Researcher : ZHONG L
List of Research Outputs

Liang Q., Zhong L., Zhang J., Wang Y., Bornstein S.R., Hong D., Triggle C. and Xu A., FGF21 Maintains Glucose Homeostasis by Mediating the Cross Talk Between Liver and Brain During Prolonged Fasting., Diabetes. 2014, Jul 14 Epub ahead of print.
WANG Y., Xiao Y., ZHONG L., Ye D., Zhang J., Tu Y., Bornstein S.R., Zhou Z., Lam K.S.L. and Xu A., Increased Neutrophil Elastase and Proteinase 3 and Augmented NETosis Are Closely Associated With  -Cell Autoimmunity in Patients With Type 1 Diabetes, Diabetes. 2014, 63: 4239-4248.


Researcher : Zhang J
List of Research Outputs

Liang Q., Zhong L., Zhang J., Wang Y., Bornstein S.R., Hong D., Triggle C. and Xu A., FGF21 Maintains Glucose Homeostasis by Mediating the Cross Talk Between Liver and Brain During Prolonged Fasting., Diabetes. 2014, Jul 14 Epub ahead of print.
WANG Y., Xiao Y., ZHONG L., Ye D., Zhang J., Tu Y., Bornstein S.R., Zhou Z., Lam K.S.L. and Xu A., Increased Neutrophil Elastase and Proteinase 3 and Augmented NETosis Are Closely Associated With  -Cell Autoimmunity in Patients With Type 1 Diabetes, Diabetes. 2014, 63: 4239-4248.


Researcher : Zhang L
List of Research Outputs

Lee S.W.L., Lam S.C.C., Kong S.L., Chan K.W.K., Tam C.C., Wong K.L., Wong A.Y.T., Yung A.S.Y., Shea C.P., Zhang L. and Wu K.Y.K., TCT-367 2-Year Sequential OCT Follow-up Findings and 3-Year Clinical Outcomes of the New Dual Therapy Endothelial Progenitor Cell Capturing Sirolimus-eluting COMBO Stent: The EGO-COMBO Study, Journal of the American College of Cardiology. 2014, 64: B107.


Researcher : Zhang Q
List of Research Outputs

JIANG N., Yung S.S.Y., Chau K.M., Zhang Q. and Chan D.T.M., Decorin Suppresses Mesothelial Cell Epithelial-to-Mesenchymal Transition, 15th Congress of the International Society for Peritoneal Dialysis. 2014.
Yap Y.H.D., Yung S.S.Y., Zhang Q., Tang S.O.C. and Chan D.T.M., Mesangial cell-binding activity of serum immunoglobulin G in patients with lupus nephritis, PLoS One. 2014, 9(7): e101987.
Yung S.S.Y., Ng C.Y., Ho S.K., Cheung K.F., Chan K.W., Zhang Q., Chau K.M. and Chan D.T.M., Anti-dsDNA antibody induces soluble fibronectin secretion by proximal renal tubular epithelial cells and downstream increase of TGF-β1 and collagen synthesis, Journal of Autoimmunity. 2015, 58: 111-122.
Yung S.S.Y., JIANG N., Chau K.M., Zhang Q. and Chan D.T.M., Decorin Ameliorates Peritoneal Fibrosis in Peritoneal Dialysis Related Peritonitis, American Society of Nephrology Kidney Week 2014.


Researcher : Zhang Y
Project Title:Important roles of Rap1/NF-κB signal pathway in regulation of mesenchymal stem cells (MSCs)-secreted cytokines and survival in myocardial infarction
Investigator(s):Zhang Y, Lian Q
Department:Ophthalmology
Source(s) of Funding:Small Project Funding
Start Date:05/2015


List of Research Outputs

LI X., Michaeloudes C., Zhang Y., Lian Q., Mak J.C.W., Bhavsar P.K. and Chung K., Oxidative stress-induced mitochondria alteration in human airway smooth muscle cells and mesenchymal stem cells, Am J Respir Crit Care Med. 2015, 191: A5544.
LIANG Y., LI X., Zhang Y., ZHEN Z., Yeung S.C., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Amelioration of cigarette smoke-induced cardiac dysfunction and inflammation by mesenchymal stem cells, J HK Coll Cardiol. 2014, 22: 49.
LIANG Y., LI X., Zhang Y., ZHEN Z., Yeung S.C., Ip M.S.M., Tse H.F., Lian Q. and Mak J.C.W., Outstanding Oral presentation - Amelioration of cigarette smoke-induced cardiac dysfunction and inflammation by mesenchymal stem cells , 18th Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine. 2014.
Li X., Zhang Y., Yeung S.C., Liang Y., Li X., Ding Y., Ip M.S.M., Tse H.F., Mak J.C.W. and Lian Q., Mitochondrial transfer of induced pluripotent stem cells-derived MSCs to airway epithelial cells attenuates cigarette smoke-induced damage, American Journal of Respiratory Cell and Molecular Biology. 2014, 51(3): 455-465.


Researcher : Zheng C
List of Research Outputs

LI Y., Lam S.K., ZHENG C., LEUNG L.L. and Ho J.C.M., The effect of tumor microenvironment on autophagy and sensitivity to targeted therapy in EGFR-mutated lung adenocarcinoma , 21st Hong Kong International Cancer Congress. 2014.
Lam S.K., LI Y., ZHENG C., LEUNG L.L. and Ho J.C.M., Combination Effect of Arsenic Trioxide and FGFR Inhibitor through Downregulation of FGFR, Akt and Erk in Squamous Cell Lung Carcinoma, 21st Hong Kong International Cancer Congress. 2014.
Lam S.K., LI Y., ZHENG C. and Ho J.C.M., Downregulation of Thymidylate Synthase and E2F1 by Arsenic Trioxide in Mesothelioma , Work Injury Prevention and Rehabilitation 2014.
Lam S.K., LI Y., ZHENG C. and Ho J.C.M., Downregulation of thymidylate synthase and E2F1 by arsenic trioxide in mesothelioma., International journal of oncology. 2014, 46: 113-22.
Lam S.K., LI Y., ZHENG C., LEUNG L.L. and Ho J.C.M., E2F1 Downregulation by Arsenic Trioxide in Lung Adenocarcinoma, International Journal of Oncology. 2014, 45: 2033-43.
Li Y.V., Lam S.K., Zheng C. and Ho J.C.M., The Effect of Tumor Microenvironment on Autophagy and Sensitivity to Targeted Therapy in EGFR-Mutated Lung Adenocarcinoma, Journal of Cancer. 2015, 6: 382-386.
ZHENG C., Lam S.K., LI Y., LEUNG L.L. and Ho J.C.M., Arsenic trioxide-induced cytotoxicity in small cell lung cancer via altered redox homeostasis and mitochondrial integrity , 21st Hong Kong International Cancer Congress. 2014.
ZHENG C., Lam S.K., LI Y. and Ho J.C.M., Arsenic trioxide-induced cytotoxicity in small cell lung cancer via altered redox homeostasis and mitochondrial integrity., International journal of oncology. 2014, 46: 1067-1078.


Researcher : Zhong L
List of Research Outputs

Liang Q., Zhong L., Zhang J., Wang Y., Bornstein S.R., Hong D., Triggle C. and Xu A., FGF21 Maintains Glucose Homeostasis by Mediating the Cross Talk Between Liver and Brain During Prolonged Fasting., Diabetes. 2014, Jul 14 Epub ahead of print.
WANG Y., Xiao Y., ZHONG L., Ye D., Zhang J., Tu Y., Bornstein S.R., Zhou Z., Lam K.S.L. and Xu A., Increased Neutrophil Elastase and Proteinase 3 and Augmented NETosis Are Closely Associated With  -Cell Autoimmunity in Patients With Type 1 Diabetes, Diabetes. 2014, 63: 4239-4248.


Researcher : Zhou M
List of Research Outputs

SHU L., WU X., CHEONG L.Y., Zhou M., Lam K.S.L., Xu A. and Hoo R.L.C., Adipocyte fatty acid binding protein (A-FABP) is a potential regulator of adaptive thermogenesis, Tenth international symposium on healthy aging"A decade of positive aging ". 2015.
Zhou M., PAN Y., SHU L., Lam K.S.L., Xu A. and Hoo R.L.C., A-FABP is a potential mediator of diabetic cardiomyopathy and ischemic reperfusion induced cardiac injury , 17th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM) . 2014.


Researcher : Zhu CF
Project Title:Deciphering the role of adipose tissue inflammation and adipokines in gut microbiota-induced systemic insulin resistance and metabolic dysregulation
Investigator(s):Zhu CF, Xu A
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:01/2015


List of Research Outputs

Zhu C.F., Integration Of Production, Study And Research Of Life Active Peptide, 生物活性短肽的产学研集成研究, In: Cui Feng zhu, Third Prize Of 2014 Chinese Medical Science Award. 2014年度中华医学科技奖 三等奖, 2014.
Zhu C.F., National Nutrition Industry Advanced Workers, 全国营养行业先进工作者, In: Cui Feng Zhu, Chinese Society Of Nutrition. 中国营养学会, 2015.
Zhu C.F., National Nutrition Industry Advanced Workers, 全国营养行业先进工作者, Chinese Society Of Nutrition. 中国营养学会, 2015.


Researcher : Zhu H
List of Research Outputs

Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Best Abstract in Clinical Medicine (Oral) - "Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial", 20th Medical Research Conference 2015, Department of Medicine, The University of Hong Kong . 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial, 20th Medical Research Conference, The University of Hong Kong, 17 Jan 2015. (Oral presentation - Best abstract in Clinical Medicine) . 2015.
Hung I.F.N., Zhang J., To K.K.W., Chan J.F.W., Li C., Zhu H., Li T.W., Li P.Y., Chan T.C.I., Cheng V.C.C., Chan K.H. and Yuen K.Y., Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial, Clinical Infectious Diseases . 2014, 59(9): 1246-55.
Li C., Li C., Zhang J., To K.K.W., Lee C.Y., Zhu H., Wu W.L., Chan J.F.W., Chen H., Hung I.F.N., Li L. and Yuen K.Y., Avian Influenza A H7N9 Virus Induces Severe Pneumonia in Mice without Prior Adaptation and Responds to a Combination of Zanamivir and COX-2 Inhibitor , PLoS One. 2014, 9(9): e107966.


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