DEPT OF ANATOMY
| Researcher : CHEN Y |
| List of Research Outputs |
| CHEN Y., Role of exchange protein directly activated by cAMP in white adipose tissue browning and lipolysis: implications on metabolic disorders, 2015, 181 pages. |
| Researcher : CHENG SY |
| List of Research Outputs |
| Chang R.C.C., WONG T.H.G., TSANG A.W.-.T., Hung C.H.L., CHENG S.Y. and Law A.C.K., Evaluation of microtubules and tau in corticosterone-induced depression, similar pathological processes as in beta-amyloid peptide neurotoxicity., The 12th International Conference on Alzheimer's and Parkinson's Diseases. 2015. |
| Ho W.L., LEUNG Y., CHENG S.Y., Lok C.K.M., Ho Y.S., Baum L., Yang X., Chiu K. and Chang R.C.C., Investigating degeneration of the retina in young and aged tau P301L mice, Life Science. 2015, 124: 16-23. |
| YOU R., CHENG S.Y., Hung C.H.L., Ho Y.S. and Chang R.C.C., Investigating the effects of FITC-tagged SiO2-NPs on tau and synaptic protein in primary culture of cortical neurons, The 10th International Symposium on Healthy Aging. 2015. |
| Researcher : Carret A |
| List of Research Outputs |
| Carret A., Pace C.H.L., Gourmaud S., Ravasi L., Montagne-Stora S., Longueville S., Tible M., Sudol E., Chang R.C.C., Paquet C., Mouton-Liger F. and Hugon J., Neuroinflammation and Abeta accumulation linked to systemic inflammation are decreased b genetic PKR down-regulation, Science Report. 2015, 5: 8489. |
| Researcher : Chan CWY |
| Project Title: | Human embryonic stem cell-derived cardiomyocyte as a model to study the role of autophagy in cardiac inflammation |
| Investigator(s): | Chan CWY, Li RA |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 11/2013 |
| Project Title: | Costimulation blockade to promote survival of human embryonic stem cell-derived cardiomyocytes in a humanized mouse model. |
| Investigator(s): | Chan CWY |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2014 |
| List of Research Outputs |
| CHEN G., LI S., Karakikes I., Ren L., Chow M.Z.Y., Chopra A., Keung W.W.Y., Yan B., Chan C.W.Y., Costa K.D., Kong M.C.W., Hajjar R.J., Chen C.S. and Li R.A., Phospholamban as a Crucial Determinant of the Inotropic Response of Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes and Engineered 3D Tissue Constructs, Circulation: Arrhythmia and Electrophysiology. 2014. |
| Chen Y., Wang J., Shen B. and Chan C.W.Y., Engineering a freestanding biomimetic cardiac patch using biodegradable poly(lactic-co-glycolic acid) (PLGA) and human embryonic stem cell-derived ventricular cardiomyocytes (hESC-VCMs)., 2015. |
| Weng J.Z., Kong M.C.W., Ren L., Karakikes I., Geng L., HE J., Chow M.Z.Y., Mok C.F., Keung W.W.Y., Chow C.H., Leung A.Y.H., Hajjar R.J., Li R.A. and Chan C.W.Y., A simple, cost-effective but highly efficient system for deriving ventricular cardiomyocytes from human pluripotent stem cells. PMID: 24564569 , Stem Cells & Development. 2014, 23(14): 1704-16. |
| Researcher : Chan HHL |
| List of Research Outputs |
| So K.F., Li H., Chiu K., Chiu K., Chan H.H.L., Chang R.C.C., Kau W.F. and Ruan Y.W., Effect of Lycium barbarum (Wolfberry) on Alleviating Axonal Degeneration After Partial Optic Nerve Transection, Cell Transplantation. USA, Cognizant Comm. Corp., 2015, 24: 403-417. |
| Researcher : Chan TK |
| Project Title: | Redeveloping a governance model of the complaint-handling process for sufficient, accountable and transparent regulation of medical professionals in Hong Kong |
| Investigator(s): | Chan TK |
| Department: | Anatomy |
| Source(s) of Funding: | Public Policy Research Funding Scheme |
| Start Date: | 01/2015 |
| Project Title: | Governing information disclosure for consent to invasive medical procedures: an empirical and normative study |
| Investigator(s): | Chan TK |
| Department: | Anatomy |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 01/2015 |
| Completion Date: | 01/2015 |
| Researcher : Chan WY |
| Project Title: | The biological and genetic determinants of seasonal influenza A virus replication in the lower respiratory tract |
| Investigator(s): | Chan WY, Chan MCW, Yen H, Nicholls JM, Peiris JSM |
| Department: | Pathology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 02/2011 |
| Completion Date: | 09/2014 |
| Project Title: | Neutrophil mediated host-responses during influenza A virus infection, an in vitro study |
| Investigator(s): | Chan WY, Chan MCW, Shum DKY, Nicholls JM, Peiris JSM |
| Department: | Pathology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 03/2012 |
| Project Title: | The application of swine and human respiratory organ explant cultures to investigate inter-species transmission of avian influenza viruses to swine and humans |
| Investigator(s): | Chan WY, Chan MCW, Nicholls JM, Peiris JSM |
| Department: | School of Public Health |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2013 |
| Project Title: | Influenza B virus induced host innate immune response in human primary alveolar epithelial cells |
| Investigator(s): | Chan WY |
| Department: | Pathology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2013 |
| Completion Date: | 06/2015 |
| Project Title: | Human lung local immunity to influenza virus - role of lung antibody and resident memory T cells |
| Investigator(s): | Chan WY, Tu W, Nicholls JM, Peiris JSM |
| Department: | School of Public Health |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Completion Date: | 04/2015 |
| Project Title: | Influenza B viruses: Virus tropism in human and swine respiratory organ explant cultures and sero-epidemiology in swine |
| Investigator(s): | Chan WY, Chan MCW, Nicholls JM, Peiris JSM |
| Department: | School of Public Health |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2014 |
| Project Title: | Is the loss of glycosylation in haemagglutinin protein a strategy for influenza virus to adapt in pigs? |
| Investigator(s): | Chan WY |
| Department: | School of Public Health |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Completion Date: | 04/2015 |
| List of Research Outputs |
| Wu Y., Li Y., Zhang H., Huang Y., Zhao P., Tang Y., Qiu X., Ying L., Li W., Ni S., Zhang M., Liu L., Xu Y., Zhuang Q., Luo Z., Benda C., Song H., Liu B., Lai L., Liu X., Tse H.F., Bao X., Chan W.Y., Esteban M.A., Qin B. and Pei D., 10. Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming., Nat Cell Biol. 2015, 17(6): 715-725. |
| Researcher : Chang R.C.C. |
| Project Title: | Significance of molecular signaling for protein translation control in neurodegeneration of amyotrophic lateral sclerosis |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Liu Po Shan/Dr Vincent Liu Endowment Fund for Motor Neuron diseases - General Award |
| Start Date: | 03/2008 |
| Project Title: | Investigating tau degradation: the underlying mechanisms for the pathogenesis of Alzheimer’s disease |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2014 |
| Completion Date: | 04/2015 |
| Project Title: | Society for Neuroscience 2014; Investigating the effects of anesthetic dexmedetomidine on tau phosphorylation |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2014 |
| Completion Date: | 11/2014 |
| Project Title: | Elucidating pathological mechanisms of visual impairment in the pathogenesis of Alzheimer’s disease: from basic science to innovative approach of disease monitoring (CRF) |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding for Incubating Group-based Collaborative Research Projects |
| Start Date: | 01/2015 |
| Project Title: | Elucidating the molecular defects associated with PTEN mutations in Autism Spectrum Disorders |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 04/2015 |
| Project Title: | Advancement for developing drug against Lewy Body Dementia by establishing a pre-clinical experimental model |
| Investigator(s): | Chang RCC, Ho YS, Ng TW, Chu MT |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 04/2015 |
| Project Title: | Investigating molecular mechanisms underlying escitalopram as neuroprotectant & antidepressant in AD mice |
| Investigator(s): | Chang RCC, Ho YS, Ng TW, Hung CHL |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2015 |
| Project Title: | Investigating oxyresveratrol as potential neuroprotective drug in experimental models of Parkinson’s disease |
| Investigator(s): | Chang RCC, Ng KM, Wang M, Ho YS |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2015 |
| Project Title: | Investigation of drugs targeting mitochondrial dynamics and reactive oxygen species for Parkinson’s disease treatment using in vitro and in vivo imaging models |
| Investigator(s): | Chang RCC, Hung CHL |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Researcher : Chang RCC |
| Project Title: | Significance of molecular signaling for protein translation control in neurodegeneration of amyotrophic lateral sclerosis |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Liu Po Shan/Dr Vincent Liu Endowment Fund for Motor Neuron diseases - General Award |
| Start Date: | 03/2008 |
| Project Title: | Investigating tau degradation: the underlying mechanisms for the pathogenesis of Alzheimer’s disease |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2014 |
| Completion Date: | 04/2015 |
| Project Title: | Society for Neuroscience 2014; Investigating the effects of anesthetic dexmedetomidine on tau phosphorylation |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2014 |
| Completion Date: | 11/2014 |
| Project Title: | Elucidating pathological mechanisms of visual impairment in the pathogenesis of Alzheimer’s disease: from basic science to innovative approach of disease monitoring (CRF) |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding for Incubating Group-based Collaborative Research Projects |
| Start Date: | 01/2015 |
| Project Title: | Elucidating the molecular defects associated with PTEN mutations in Autism Spectrum Disorders |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 04/2015 |
| Project Title: | Advancement for developing drug against Lewy Body Dementia by establishing a pre-clinical experimental model |
| Investigator(s): | Chang RCC, Ho YS, Ng TW, Chu MT |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 04/2015 |
| Project Title: | Investigating molecular mechanisms underlying escitalopram as neuroprotectant & antidepressant in AD mice |
| Investigator(s): | Chang RCC, Ho YS, Ng TW, Hung CHL |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2015 |
| Project Title: | Investigating oxyresveratrol as potential neuroprotective drug in experimental models of Parkinson’s disease |
| Investigator(s): | Chang RCC, Ng KM, Wang M, Ho YS |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2015 |
| Project Title: | Investigation of drugs targeting mitochondrial dynamics and reactive oxygen species for Parkinson’s disease treatment using in vitro and in vivo imaging models |
| Investigator(s): | Chang RCC, Hung CHL |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Carret A., Pace C.H.L., Gourmaud S., Ravasi L., Montagne-Stora S., Longueville S., Tible M., Sudol E., Chang R.C.C., Paquet C., Mouton-Liger F. and Hugon J., Neuroinflammation and Abeta accumulation linked to systemic inflammation are decreased b genetic PKR down-regulation, Science Report. 2015, 5: 8489. |
| Chang R.C.C., An overview of pathophysiological mechanisms of risk factors for dementia, The 9th Pan-Pacific Conference on Rehabilitation cum 21th Annual Congress of Gerontology. 2014. |
| Chang R.C.C., Editorial Board Member, Advances in Alzheimer's Disease. 2014. |
| Chang R.C.C., Editorial Board Member, Advances in Neuroscience Research. 2014. |
| Chang R.C.C., Editorial Board Member, American Journal of Alzheimer's Disease and Other Dementia. 2014. |
| Chang R.C.C., Editorial Board Member, Asian Journal of Neuroscience. 2014. |
| Chang R.C.C., Editorial Board Member, Chinese Medicine. 2014. |
| Chang R.C.C., Editorial Board Member, Dataset Paper in Neuroscience. 2014. |
| Chang R.C.C., Editorial Board Member, HSOA Journal of Alzheimer's & Neurodegenerative Diseases. 2014. |
| Chang R.C.C., Editorial Board Member, International Journal of Ophthalmic Research. 2014. |
| Chang R.C.C., Editorial Board Member, Neural Regeneration Research. 2014. |
| Chang R.C.C., Editorial Board Member, Neuroimmunology and Neuroinflammation. 2014. |
| Chang R.C.C., Editorial Board Member, Neurology, Open Access. 2014. |
| Chang R.C.C., Editorial Board Member, The Open Enzyme Inhibition Journal. 2014. |
| Chang R.C.C., Editorial Board Memeber, International Journal of Clinical and Experimental Medicine. 2014. |
| Chang R.C.C., Editorial Board member, Anatomy and Physiology: Current Research. 2014. |
| Chang R.C.C., Editorial Board member, Dataset Paper in Medicine (Ophthalmology). 2014. |
| Chang R.C.C., Editorial Board member, Journal of Brain and Behavioral Sciences. 2014. |
| Chang R.C.C., Editorial Board member, Journal of Neurology and Psychology. 2014. |
| Chang R.C.C., WONG T.H.G., TSANG A.W.-.T., Hung C.H.L., CHENG S.Y. and Law A.C.K., Evaluation of microtubules and tau in corticosterone-induced depression, similar pathological processes as in beta-amyloid peptide neurotoxicity., The 12th International Conference on Alzheimer's and Parkinson's Diseases. 2015. |
| Chang R.C.C., Guest Editor, BioMed Research International. 2014. |
| Chang R.C.C., Handling Associate Editor, Journal of Alzheimer's Disease. 2014. |
| Chang R.C.C. and So K.F., In: Raymond Chuen Chung Chang & Kwok-Fai So, Lycium Barbarum and Human Health. Dordrecht, Springer, 2015, 1-198. |
| Chang R.C.C., Section Chief Editor, Journal of Neuroimmune Pharmacology. 2014. |
| Chang R.C.C., Visual impairment in Alzheimer's disease, International Alzheimer's Disease Conference. 2015. |
| Chu M.T., Lau C.F., Chang R.C.C. and Wong G.T.C., Exploring the potential impact of endurance exercise in Alzheimer’s disease, International Alzheimer’s Disease Conference 2015. |
| HUANG C., Ng T.W., Chu M.T., Chang R.C.C. and Wong G.T.C., Correlation between tau hyperphosphorylation and inflammation in post operative cognitive dysfunction, International Alzheimer’s Disease Conference 2015. |
| HUANG C., Ho Y.S., Ng T.W., Irwin M.G., Chang R.C.C. and Wong G.T.C., Dexmedetomidine directly increases tau phosphorylation, Journal of Alzheimer's Disease. 2015, 44: 839-850. |
| Ho W.L., LEUNG Y., CHENG S.Y., Lok C.K.M., Ho Y.S., Baum L., Yang X., Chiu K. and Chang R.C.C., Investigating degeneration of the retina in young and aged tau P301L mice, Life Science. 2015, 124: 16-23. |
| Ho Y.S., Li X.A., Hung C.H.L. and Chang R.C.C., Prevention of neurodegeneration for Alzheimer's disease by Lycium barbarum, In: Raymond Chuen-Chung Chang & Kwok-Fai So, Lycium barbarum and Human Health. Dordrecht, Springer, 2015, Chapter 7: 99-111. |
| Kwan S.K.J., Chu L.W., Chan H.W.F., Lee T.M.C., Law A.C.K., Mak H.K.F., Cheung R.T.F., Chang R.C.C., Lum T.Y.S. and Tang S.C.W., Comparing vascular dementia and Alzheimer’s dementia: a preliminary, cross-sectional, multimodal comparative study evaluating clinical and cognitive profile, neuroimaging, biomarkers and quantitative EEG ($240,000), Seed Funding HKU. 2014. |
| Kwan S.K.J., Tang Y.M.J., Wong G.H.Y., Chang R.C.C. and Lum T.Y.S., Comparison of characteristics of people with subjective cognitive impairment vs. mild cognitive impairment vs. dementia: cross-sectional data from the Hong Kong Alzheimer’s Disease Association, International Alzheimer’s Disease Conference 2015 (HKU). 2015. |
| Kwan S.K.J., Tang Y.M.J., Wong G.H.Y., Chang R.C.C. and Lum T.Y.S., Outstanding Investigator Award (1st Runner Up), International Alzheimer’s Disease Conference 2015 (HKU). 2015. |
| LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Chan Y.S., Cheung K.H. and Fung M.L., Lycium barbarum polysaccharides antagonized rat hippocampal-dependent spatial memory deficits induced by chronic intermittent hypoxia. The 8th Pong Ding Yuen International Symposium on Traditional Chinese medicine cum The 2nd International Chinese Symposium on Free Radical Research , The 6th Symposium for Three Districts of Cross-straits on Free Radical Research, HK 11/2014. |
| LEUNG W.Y.Y., Ng T.W., Chu M.T., Chang R.C.C. and Wong G.T.C., Investigating the modulatory effects of sevoflurane on systemic inflammation-induced cognitive dysfunction, International Alzheimer’s Disease Conference 2015. |
| LIU K.L., Chang R.C.C., Pearce R.K.B.B. and Gentleman S.M., Differential pattern of neuronal loss in the cholinergic basal forebrain in Lewy body disorders., The 12th International Conference on Alzheimer's and Parkinson's Diseases. 2015. |
| LIU K.L., Chang R.C.C., Pearce R.K. and Gentleman S.M., Friedrich Lewy's Nucleus basalis of Meynert revisited: anatomy, history and differential involvement in Alzheimer's and Parkinson's disease, Acta Neuropathologie. 2015, 129: 527-540. |
| LIU K.L., Chang R.C.C., Pearce R.K.B.B. and Gentleman S.M., Subregional nucleus basalis of Meynert pathology in Lewy body disorders, The 116th Meeting of the British Neuropathological Society. 2015. |
| LIU K.L., Chang R.C.C., Pearce R.K.B. and Gentleman S.M., Where is the human nucleus basalis of Meynert?, The 116th Meeting of the British Neuropathological Society. 2015. |
| Lau G.K.K., Chan L.K., Chan K.H., Chang S.K.R., Chang R.C.C., Cheung R.T.F., Doherty I., Ho S.L., Hon S.F.K., Kwan S.K.J., Lee R., Leung G.K.K., Mak W., Shih K.C. and Tsang C.O.A., ePoster Award (First Prize), Title: Establishing an eLearning Platform in Clinical Neurosciences at HKU, HKU Li Ka Shing Faculty of Medicine Frontiers Series – East-West Alliance Global Symposia. 2014. |
| Li H., Ruan Y.W., Kau P.W.F., Chiu K., Chang R.C.C., Chang H.H.L. and So K.F., Effects of Lycium barbarum (Wolfberry) on alleviating axonal degeneration after partial optic nerve transection, Cell Transplantation. 2015, 24: 403-417. |
| Li H.Y., Chan H.H.L., Chu P.H.W., Chang R.C.C. and So K.F., Secondary degeneration after partial optic nerve injury and possible neuroprotective effects of Lycium barbarum (Wolfberry), In: Raymond Chuen-Chung Chang & Kwok-Fai So, Lycium Barbarum and Human Health. Dordrecht, Springer, 2015, Chapter 10: 135-151. |
| Mi X.S., Huang R.J., Ding Y., Chang R.C.C. and So K.F., Effects of Lycium barbarum on modulation of blood vessel and hemodynamics, In: Raymond Chuen-Chung Chang & Kwok-Fai So, Lycium Barbarum and Human Health. Dordrecht, Springer, 2015, Chapter 4: 65-77. |
| Ng T.W., HUANG C., Lau C.F., Wong G.T.C. and Chang R.C.C., The potential impact of anaesthesia induced synaptic proteins changes on post-operative cognitive dysfunction (POCD), International Alzheimer’s Disease Conference 2015. |
| So K.F., Li H., Chiu K., Chiu K., Chan H.H.L., Chang R.C.C., Kau W.F. and Ruan Y.W., Effect of Lycium barbarum (Wolfberry) on Alleviating Axonal Degeneration After Partial Optic Nerve Transection, Cell Transplantation. USA, Cognizant Comm. Corp., 2015, 24: 403-417. |
| So K.F., Chang R.C.C., Lau W.M., Leung C.P. and Po K.T., Prosexual Effects of Lycium Barbarum, Lycium Barbarum and Human Health. London, Springer, 2015, 1-18. |
| Xiao J., Xing F., Huo J., Fung M.L., Liong E.C., Ching Y.P., Xu A., Chang R.C.C., So K.F. and Tipoe G.L., Lycium barbarum polysaccharides therapeutically improve hepatic functions in non-alcoholic steatohepatitis rats and cellular steatosis model, Scientific Reports. 2014, 4: 5587. |
| YOU R., CHENG S.Y., Hung C.H.L., Ho Y.S. and Chang R.C.C., Investigating the effects of FITC-tagged SiO2-NPs on tau and synaptic protein in primary culture of cortical neurons, The 10th International Symposium on Healthy Aging. 2015. |
| Yu J., Luo X., Ma Q., Yuan J., Li X., Chang R.C.C., Qu Z., Huang X., Zhuang Z., Liu J. and Yang X., Identification of the key molecules involved in chronic copper exposure-aggravated memory impairment in transgenic mice of Alzheimer's disease using proteomic analysis, Journal of Alzheimer's Disease. 2015, 44: 455-469. |
| Researcher : Chau RMW |
| Project Title: | HUGO's Seventh International Human Genome Meeting, HGM2002 The Possible Mechanism of Action for Quinacrine Interacting the Scrapie Protein in Prion Disease |
| Investigator(s): | Chau RMW |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2002 |
| Researcher : Chen AYS |
| Project Title: | Study of the role of polyol pathway activation the impaired nerve regeneration in diabetes |
| Investigator(s): | Chen AYS, Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2008 |
| Researcher : Cheung A |
| Project Title: | Id1-induced IGF2 promotes esophageal cancer progression through instigation of stromal fibroblasts and bone marrow-derived vascular progenitor cells |
| Investigator(s): | Cheung A, Chan KW, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2012 |
| Project Title: | MicroRNA-377 inhibits growth and metastasis of esophageal cancer stem-like cells by directly repressing CD133 – mechanisms and implications for cancer stem cell-targeted therapy |
| Investigator(s): | Cheung A, Chan KW, Law SYK, Tsao GSW, Li B |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2013 |
| Project Title: | FBXO31 regulates stress-induced cell apoptosis by mediating K48-linked ubiquitination and degradation of phosphorylated MKK6 |
| Investigator(s): | Cheung A |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 04/2014 |
| Completion Date: | 03/2015 |
| Project Title: | 23rd Biennial Congress of the European Association for Cancer Research ; Role of Id1-IGF2-VEGF-VEGFR relay in esophageal tumorigenesis |
| Investigator(s): | Cheung A |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2014 |
| Completion Date: | 07/2014 |
| Project Title: | Roles and mechanisms of E2F1 and IGF2 in regulating chemosensitivity of esophageal cancer |
| Investigator(s): | Cheung A, Li B |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2014 |
| Project Title: | Identification of miR-29c/FBXO31 as a key regulatory mechanism in esophageal cancer chemoresistance-functional validation and implication for therapy |
| Investigator(s): | Cheung A, Li B |
| Department: | Anatomy |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2015 |
| Project Title: | Role of miR-338-5p as a novel modulator of chemoresistance in esophageal cancer |
| Investigator(s): | Cheung A, Chan KW, Law SYK, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| List of Research Outputs |
| Cheung A., XU W., Li B., Tsao G.S.W. and Chan K.W., Role of Id1-IGF2-VEGF-VEGFR relay in esophageal tumorigenesis, 23rd Biennial Congress of the European Association for Cancer Research, July 5-8, 2014 Munich, Germany.. 2014, 50 suppl. 5: S35 No. 161. |
| Cheung A., HAN L., Li B., Tsao G.S.W., Law S.Y.K., Chan K.W. and Lam A.K.Y., Role of miR-338-5p as a novel modulator of chemoresistannce in esophageal cancer, EACR AACR SIC Conference, June 20-23, Florence Italy. 2015. |
| Cheung A., 深圳虛擬大學園2014年度獲得國家級科技項目獎先進個人, 深圳市科技創新委員會, 2014. |
| Deng W., ZHOU Y., Tiwari A.F.Y., Su H., Yang J., ZHU D., LAU M.Y., Hau P.M., Yip Y.L., Cheung A., Guan X. and Tsao G.S.W., p21/Cyclin E pathway modulates anticlastogenic function of Bmi-1 in cancer cells., International Journal of Cancer. 2015, 136: 1361-1370. |
| HAN L., Li B., Tsao G.S.W. and Cheung A., Roles of miR-338-5p in downregulating Id1 and inhibiting chemoresistance, 21st Hong Kong International Cancer Congress, November 21, 2014, Hong Kong.. 2014, No. A16. |
| Lam C.L.D., Luo S.Y., Deng W., Kwan S.H., Rodriguez-Canales J., Cheung A., Cheng G.H.W., Lin C.H., Wistuba I.I., Sham P.C., Wan T.S.K. and Tsao G.S.W., Oncogenic mutation profiling in new lung cancer and mesothelioma cell lines, OncoTargets and Therapy. 2015, 8: 195-209. |
| Li B., XU W., Guan X., Law S.Y.K., Tsao G.S.W. and Cheung A., Suppression of esophageal tumor growth and chemoresistance by directly targeting the PI3K/AKT pathway, 2014 World Cancer Congress,December 3-6, Melbourne, Australia.. 2014, Abstract No. 1196. |
| Li B., Li J., Xu W., Guan X., Qin Y.R., Zhang L., Law S.Y.K., Tsao G.S.W. and Cheung A., Suppression of esophageal tumor growth and chemoresistance by directly targeting the PI3K/AKT pathway, Oncotarget. 2014, 5(22): 11576-11587. |
| Li B., HAN L., Chan K.W., Law S., Lam A.K.Y., Tsao G.S.W. and Cheung A., Suppressive effects of Id1-targeting microRNAs in metastasis of esophageal cancer, 21st Hong Kong International Cancer Congress, November 21, 2014, Hong Kong.. 2014, No. A17. |
| XU W., Li B., Li Y.Y., Tsao G.S.W. and Cheung A., Blocking the PI3K/AKT pathway can impair metastasis of esophageal cancer, 2014 World Cancer Congress, December 3-6, 2014, Melbourne, Australia.. 2014, Abstract No. 942. |
| XU W., Li B., Tsao G.S.W., Chan K.W. and Cheung A., IGI-induced IGF2 promotes esophageal cancer progression through instigation of stromal fibroblasts and bone marrow-drived vancular progenitor cells, 21st Hong Kong International Cancer Congress, November 21, 2014 Hong Kong. 2014, No. A11. |
| XU W., Li B., Lam A.K.Y., Tsao G.S.W., Law S.Y.K., Chan K.W., Yuan Q. and Cheung A., Targeting VEGFR-1 and VEGFR2-expressing non-tumor cells is essential for esophageal cancer therapy, Oncotarget. 2014, 6(3): 1790-1805. |
| XU W., Li B. and Cheung A., The potential of targeted antiangiogenesis therapies in the treatment of esophageal cancer, Gastrointestinal Cancer: Targets and Therapy. 2015, 5: 79-88. |
| Xu W.W., Li B., Lai E.T.C., Chen L., Huang J.J.H., Cheung A. and Cheung P.C.K., Water extract from Pleurotus pulmonarius with antioxidant activity exerts in vivo chemoprophylaxis and chemosensitization for liver cancer, Nutrition and Cancer. 2014, 66(6): 989-998. |
| Yang J., Deng W., Hau P.M., LIU J., LAU M.Y., Cheung A., Huen M.S.Y. and Tsao G.S.W., Epstein-Barr virus BZLF1 protein impairs accumulation of host DNA damage proteins at damage sites in response to DNA damage, Laboratory Investigation. 2015. |
| Researcher : Cheung A. |
| Project Title: | Id1-induced IGF2 promotes esophageal cancer progression through instigation of stromal fibroblasts and bone marrow-derived vascular progenitor cells |
| Investigator(s): | Cheung A, Chan KW, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2012 |
| Project Title: | MicroRNA-377 inhibits growth and metastasis of esophageal cancer stem-like cells by directly repressing CD133 – mechanisms and implications for cancer stem cell-targeted therapy |
| Investigator(s): | Cheung A, Chan KW, Law SYK, Tsao GSW, Li B |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2013 |
| Project Title: | FBXO31 regulates stress-induced cell apoptosis by mediating K48-linked ubiquitination and degradation of phosphorylated MKK6 |
| Investigator(s): | Cheung A |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 04/2014 |
| Completion Date: | 03/2015 |
| Project Title: | 23rd Biennial Congress of the European Association for Cancer Research ; Role of Id1-IGF2-VEGF-VEGFR relay in esophageal tumorigenesis |
| Investigator(s): | Cheung A |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2014 |
| Completion Date: | 07/2014 |
| Project Title: | Roles and mechanisms of E2F1 and IGF2 in regulating chemosensitivity of esophageal cancer |
| Investigator(s): | Cheung A, Li B |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2014 |
| Project Title: | Identification of miR-29c/FBXO31 as a key regulatory mechanism in esophageal cancer chemoresistance-functional validation and implication for therapy |
| Investigator(s): | Cheung A, Li B |
| Department: | Anatomy |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2015 |
| Project Title: | Role of miR-338-5p as a novel modulator of chemoresistance in esophageal cancer |
| Investigator(s): | Cheung A, Chan KW, Law SYK, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| List of Research Outputs |
| Researcher : Cheung ALM |
| Project Title: | Id1-induced IGF2 promotes esophageal cancer progression through instigation of stromal fibroblasts and bone marrow-derived vascular progenitor cells |
| Investigator(s): | Cheung A, Chan KW, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2012 |
| Project Title: | MicroRNA-377 inhibits growth and metastasis of esophageal cancer stem-like cells by directly repressing CD133 – mechanisms and implications for cancer stem cell-targeted therapy |
| Investigator(s): | Cheung A, Chan KW, Law SYK, Tsao GSW, Li B |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2013 |
| Project Title: | FBXO31 regulates stress-induced cell apoptosis by mediating K48-linked ubiquitination and degradation of phosphorylated MKK6 |
| Investigator(s): | Cheung A |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 04/2014 |
| Completion Date: | 03/2015 |
| Project Title: | 23rd Biennial Congress of the European Association for Cancer Research ; Role of Id1-IGF2-VEGF-VEGFR relay in esophageal tumorigenesis |
| Investigator(s): | Cheung A |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2014 |
| Completion Date: | 07/2014 |
| Project Title: | Roles and mechanisms of E2F1 and IGF2 in regulating chemosensitivity of esophageal cancer |
| Investigator(s): | Cheung A, Li B |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2014 |
| Project Title: | Identification of miR-29c/FBXO31 as a key regulatory mechanism in esophageal cancer chemoresistance-functional validation and implication for therapy |
| Investigator(s): | Cheung A, Li B |
| Department: | Anatomy |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2015 |
| Project Title: | Role of miR-338-5p as a novel modulator of chemoresistance in esophageal cancer |
| Investigator(s): | Cheung A, Chan KW, Law SYK, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| List of Research Outputs |
| Researcher : Cheung MCH |
| Project Title: | In vivo Functional Analysis of Posttranslational Modifications of Sox9 in Neural Crest Development |
| Investigator(s): | Cheung MCH, Zhou G |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2010 |
| Project Title: | Investigating the roles of SOX9 in human neural stem cells |
| Investigator(s): | Cheung MCH |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | 2014 International SOX Research Conference; Sox9 and the molecular network regulating neural crest cell motility |
| Investigator(s): | Cheung MCH |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2014 |
| Completion Date: | 09/2014 |
| Project Title: | In vivo functional characterization of a Rho GTPase-activating protein, DLC1, in neural crest development |
| Investigator(s): | Cheung MCH |
| Department: | Anatomy |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 10/2014 |
| Project Title: | Single-cell transcriptomics in Sertoli cells and neural crest cells |
| Investigator(s): | Cheung MCH |
| Department: | Anatomy |
| Source(s) of Funding: | SFC / RGC Joint Research Scheme |
| Start Date: | 01/2015 |
| Project Title: | Elucidating the contribution of cross-regulatory interactions between SOX9 and SOX10 to melanoma progression |
| Investigator(s): | Cheung MCH, Lung HL |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2015 |
| List of Research Outputs |
| Cheung M.C.H., Molecular Control of Epithelial-Mesenchymal Transitions in Neural Crest Development and Tumor Progression, 2014. |
| Cheung M.C.H., HO S.H., Hui M.N., Wu M.H., Cheung M.P.L., Ho C.K.Y., Niu B., Cheah K.S.E. and LIU A., Sox9 and the Molecular Network Regulating Neural Crest Cell Motility, 2014 International SOX Research Conference. 2014. |
| YIP K.H.R., Au Y.K., Yang W., Cheung M.C.H., Chan D. and Cheah K.S.E., Towards Understanding Genetic and Molecular Etiology of Campomelic Dysplasia, 19th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 10 & 11, 2014. |
| Researcher : Cheung MPL |
| List of Research Outputs |
| Cheung M.C.H., HO S.H., Hui M.N., Wu M.H., Cheung M.P.L., Ho C.K.Y., Niu B., Cheah K.S.E. and LIU A., Sox9 and the Molecular Network Regulating Neural Crest Cell Motility, 2014 International SOX Research Conference. 2014. |
| PAN Y., DAI Y., Cheung M.P.L. and Yip H.K.F., The Inhibition Of GSK3β Promotes Oligodendroglial Progenitor Cell Differentiation In Spinal Cord Injury, Federation Of European Neuroscience Societies Annual Meeting. 2014. |
| Wong P.F., Cheung M.P.L., O W.S. and Tang F., Intermedin inhibits norepinephrine - induced contraction of rat seminal vesicle, Asia Pacific Journal of Reproduction. 2014, 3(3): 176-179. |
| Researcher : Cheung YC |
| List of Research Outputs |
| Tsang C.M., Cheung K.C., Cheung Y.C., Man K., Lui W.Y.V., Feng Y. and Tsao G.S.W., Berberine suppresses Id-1 expression and inhibits the growth and development of lung metastases in hepatocellular carcinoma, Biochimica et Biophysica Acta. 2014, Epub on 2014-12-08. |
| Researcher : Ching Y.P. |
| Project Title: | Roles of p21-activated protein kinase (Pak) 1 in the pathogenesis of liver cancer |
| Investigator(s): | Ching YP, Ng IOL, Jin D, Yau TO |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2006 |
| Project Title: | Hepatitis B virus promotes hepatocarcinogenesis by activation of Pak1 |
| Investigator(s): | Ching YP, Jin D |
| Department: | Anatomy |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2010 |
| Completion Date: | 08/2014 |
| Project Title: | HBx oncoprotein induces chromosome instability in hepatocarcinogenesis via dysregulation of centrosome duplication regulatory protein, TAX1BP2 |
| Investigator(s): | Ching YP, Jin D |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2013 |
| Project Title: | The role of centrosomal kinase Nek2 in the pathogenesis of liver cancer |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2013 |
| Completion Date: | 04/2015 |
| Project Title: | Functional characterization of the roles of NIMA-related kinase, Nek2 in liver cancer development and metastasis |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Functional characterization of the roles of NIMA-related kinase, Nek2 in liver cancer development and metastasis |
| Investigator(s): | Ching YP, Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | The therapeutic potential of Polo-like protein kinase 4 in liver cancer |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2015 |
| Project Title: | WIN 2015 Symposium, Novel Targets, Innovative agents, advanced technologies: A Winnning Strategy; The centrosomal protein, TAX1 binding protein 2 (TAX1BP2) regulates the chemo-sensitivity of liver cancer cells |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Researcher : Ching YP |
| Project Title: | Roles of p21-activated protein kinase (Pak) 1 in the pathogenesis of liver cancer |
| Investigator(s): | Ching YP, Ng IOL, Jin D, Yau TO |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2006 |
| Project Title: | Hepatitis B virus promotes hepatocarcinogenesis by activation of Pak1 |
| Investigator(s): | Ching YP, Jin D |
| Department: | Anatomy |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2010 |
| Completion Date: | 08/2014 |
| Project Title: | HBx oncoprotein induces chromosome instability in hepatocarcinogenesis via dysregulation of centrosome duplication regulatory protein, TAX1BP2 |
| Investigator(s): | Ching YP, Jin D |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2013 |
| Project Title: | The role of centrosomal kinase Nek2 in the pathogenesis of liver cancer |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2013 |
| Completion Date: | 04/2015 |
| Project Title: | Functional characterization of the roles of NIMA-related kinase, Nek2 in liver cancer development and metastasis |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Functional characterization of the roles of NIMA-related kinase, Nek2 in liver cancer development and metastasis |
| Investigator(s): | Ching YP, Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | The therapeutic potential of Polo-like protein kinase 4 in liver cancer |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2015 |
| Project Title: | WIN 2015 Symposium, Novel Targets, Innovative agents, advanced technologies: A Winnning Strategy; The centrosomal protein, TAX1 binding protein 2 (TAX1BP2) regulates the chemo-sensitivity of liver cancer cells |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Lai W.L., Hung W.Y. and Ching Y.P., The tumor suppressor, TAX1BP2, is a novel substrate of ATM kinase, Oncogene. Macmillan Publishers Limited, 2014, 33: 5303-5309. |
| Tse E.Y.T. and Ching Y.P., The role of p21-activated kinases in hepatocellular carcinoma metastasis, Journal of Molecular Signaling . BioMed Central, 2014, 9. |
| Xiao J., Xing F., Huo J., Fung M.L., Liong E.C., Ching Y.P., Xu A., Chang R.C.C., So K.F. and Tipoe G.L., Lycium barbarum polysaccharides therapeutically improve hepatic functions in non-alcoholic steatohepatitis rats and cellular steatosis model, Scientific Reports. 2014, 4: 5587. |
| Yau S.Y., LI A., Hoo R.L.C., Ching Y.P., Christie B... .R..., Lee T.M.C., Xu A. and So K.F., Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin, Proceedings of the National Academy of Sciences. United States of America, Proceedings of the National Academy of Sciences of the US, 2014, 111: 15810-15815. |
| Researcher : Chiu K |
| Project Title: | Neuroprotective and axonal regenerative effect of trans-scleral electrical stimulation on optic nerve crush induced retinal ganglion cell degeneration |
| Investigator(s): | Chiu K, Lai JSM, So KF, Lee VWH |
| Department: | Ophthalmology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2015 |
| List of Research Outputs |
| So K.F., Li H., Chiu K., Chiu K., Chan H.H.L., Chang R.C.C., Kau W.F. and Ruan Y.W., Effect of Lycium barbarum (Wolfberry) on Alleviating Axonal Degeneration After Partial Optic Nerve Transection, Cell Transplantation. USA, Cognizant Comm. Corp., 2015, 24: 403-417. |
| Researcher : Chung SK |
| Project Title: | Stem Cell Strategy for Nervous System Disorders |
| Investigator(s): | Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 09/2012 |
| Project Title: | Molecular Basis for Diabetes-induced Painless and Painful Neuropathy, and Inability to Structurally and Functionally Recovery after Peripheral Nerve Injury |
| Investigator(s): | Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2012 |
| Project Title: | To Determine the Role of Exchange Protein Directly Activated by cAMP, Epac 1 and Epac2, in the Blood-retinal Barrier and Neuroinflammation in Retina |
| Investigator(s): | Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Aldose Reductase(AR) effect dopaminergic neuronal autophagy through microglia after acute inflammation in Parkinson’s disease |
| Investigator(s): | Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Cheung C.W., LUO X., TAI W.L., Hung K.L., Chung S.K. and Xiao M.W., Targeted over-expression of astrocytic endothelin-1 attenuates neuropathic pain by up-regulating spinal excitatory amino acid transporter-2, In: Victor KL Hung, Lydia W Tai1, Xin Luo, Xiao Min Wang, Sookja K Chung and Chi Wai Cheung, Journal of Molecular Neuroscience. 2015, 2015 (In Press). |
| Fu Z., Nian S., Li S.Y., Wong D.S.H., Chung S.K. and Lo A.C.Y., Deficiency of aldose reductase attenuates inner retinal neuronal changes in a mouse model of retinopathy of prematurity, Graefe's Archive for Clinical and Experimental Ophthalmology. 2015. |
| Guo Y., Chung S.K., Siu D.C.W., Kwan S.C., Ho W.L., Yeung P.K.K. and Chan K.H., Endothelin-1 overexpression exacerbate experimental allergic encephalomyelitis, Journal of Neuroimmunology. 2014. |
| LIU J., Chung S.K. and Lo A.C.Y., Analysis of retinal microglia spatial and temporal patterns in mouse oxygen-induced retinopathy model, Tenth International Symposium on Healthy Aging: “A Decade of Positive Aging”. 2015. |
| LIU J., Chung S.K. and Lo A.C.Y., Spatial and temporal analysis of retinal microglia in mouse oxygen-induced retinopathy model, ARVO 2015 Annual Meeting. 2015. |
| LUO X., TAI W.L., Sun L.T., QIU Q., Xia Z., Chung S.K. and Cheung C.W., Central Cxcl12/cxcr4 Axis Contributes To The Pain Induction In A Mouse Model Of Complex Regional Pain Syndrome-type I, International Anesthesia Research Society 2015 Annual Meeting And International Science Symposium. 2015. |
| LUO X., TAI W.L., Sun L.T., QIU Q., Xia Z., Chung S.K. and Cheung C.W., Central administration of C-x-C chemokine receptor type 4 antagonist alleviates the development and maintenance of peripheral neuropathic pain in mice, PLoS One. 2014, 9(8): e104860. |
| Lo A.C.Y., Fu Z., Nian S. and Chung S.K., Aldose reductase deficiency protects the neonatal mouse retina against oxygen-induced retinopathy, XXI Biennial Meeting of the International Society for Eye Research (ISER). 2014. |
| Ng C.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Lam K.S.L., Xu A. and Chan K.H., Adiponectin deficiency induced cognitive dysfunction and Alzheimer’s disease pathogenesis in mice through the disruption of insulin sensitivity and inactivated AMPK signaling , 67th American Academy of Neurology Annual Meeting. 2015. |
| Ng C.L., Cheng O.Y., Kwan S.C., Ho W.L., Cheng K.Y., Chung S.K., Lam K.S.L., Xu A. and Chan K.H., Research Travel Scholarship 2015, American Academy of Neruology. 2015. |
| Sin S.M.A., Tang W.M., Wen C., Chung S.K. and Chiu K.Y., The emerging role of endothelin-1 in the pathogenesis of subchondral bone disturbance and osteoarthritis, Osteoarthritis and Cartilage. 2015, 23: 516-524. |
| Zhang K., Zheng J., Bian G., Lu L., Xue Q., Liu F., Yu C., Zhang H., Song B. and Chung S.K., Polarized Macrophages Have Distinct Roles in the Differentiation and Migration of Embryonic Spinal-cord-derived Neural Stem Cells After Grafting to Injured Sites of Spinal Cord, Molecular Therapy. 2015, 23: 1077-1091. |
| Zhang Q., Bian G., Chen P., Liu L., Yu C., Liu F., Xue Q., Chung S.K., Song B. and Ju G., Aldose Reductase Regulates Microglia/Macrophages Polarization Through the cAMP Response Element-Binding Protein After Spinal Cord Injury in Mice, Molecular Neurobiology. 2014. |
| Researcher : DAI Y |
| List of Research Outputs |
| DAI Y., Inhibitionof STAT/SMAD co-transcription factor p300 by LiCI and noggin regulates differentiation of endogenous neural progenitors and ameliorates excessive astrogliosis and promotes functional recovery after spinal cord injury, 2015, 180 pages. |
| PAN Y., DAI Y., Cheung M.P.L. and Yip H.K.F., The Inhibition Of GSK3β Promotes Oligodendroglial Progenitor Cell Differentiation In Spinal Cord Injury, Federation Of European Neuroscience Societies Annual Meeting. 2014. |
| PAN Y., DAI Y. and Yip H.K.F., The Role of GSK3β Pathway in Oligodendroglial Progenitor Cell (OPC) Differentiation and Remyelination after Spinal Cord Injury (SCI), 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2014. |
| Researcher : Deng W |
| Project Title: | Role of Bmi-1 in the persistence of Epstein-Barr virus (EBV) in nasopharyngeal epithelial cells |
| Investigator(s): | Deng W, Tsao GSW, Huen MSY, Tsang CM |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 01/2013 |
| Project Title: | Role of short telomere profiles of cancer patients in determining cancer karyotype abnormalities |
| Investigator(s): | Deng W, Tsao GSW |
| Department: | School of Nursing |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2013 |
| Project Title: | Distinct whole-genome short telomere profiles of cancer patients in comparison with non-cancer individuals |
| Investigator(s): | Deng W, Tiwari AFY, Tsao GSW, Lam CLD |
| Department: | School of Nursing |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | A novel function of IL-6/IL-6R?signaling activation in nasopharyngeal epithelial cells: facilitation of cellular immortalization |
| Investigator(s): | Deng W, Tsao GSW, Chen H |
| Department: | School of Nursing |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Immortalization of human uterine cervical epithelial cells without viral oncogene expression |
| Investigator(s): | Deng W, Tsao GSW |
| Department: | School of Nursing |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2015 |
| List of Research Outputs |
| Yuen K.S., Chan C.P., Wong N.H.M., HO C.H., HO T.H., Lei T., Deng W., Tsao G.S.W., Chen H., Kok K.H. and Jin D., CRISPR/Cas9-mediated genome editing of Epstein-Barr virus in human cells, Journal of General Virology. 2015, 96: 626-636. |
| Researcher : Deng W. |
| Project Title: | Role of Bmi-1 in the persistence of Epstein-Barr virus (EBV) in nasopharyngeal epithelial cells |
| Investigator(s): | Deng W, Tsao GSW, Huen MSY, Tsang CM |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 01/2013 |
| Project Title: | Role of short telomere profiles of cancer patients in determining cancer karyotype abnormalities |
| Investigator(s): | Deng W, Tsao GSW |
| Department: | School of Nursing |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2013 |
| Project Title: | Distinct whole-genome short telomere profiles of cancer patients in comparison with non-cancer individuals |
| Investigator(s): | Deng W, Tiwari AFY, Tsao GSW, Lam CLD |
| Department: | School of Nursing |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | A novel function of IL-6/IL-6R?signaling activation in nasopharyngeal epithelial cells: facilitation of cellular immortalization |
| Investigator(s): | Deng W, Tsao GSW, Chen H |
| Department: | School of Nursing |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Immortalization of human uterine cervical epithelial cells without viral oncogene expression |
| Investigator(s): | Deng W, Tsao GSW |
| Department: | School of Nursing |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2015 |
| List of Research Outputs |
| Researcher : Ellis-Behnke RG |
| Project Title: | The ADME of Self-assembling Nanomaterials |
| Investigator(s): | Ellis-Behnke RG |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2008 |
| Project Title: | Incorporation Dynamics of Additives and Self-assembly peptides (SAPs) at Nanoscale for Central Nervous System (CNS) Regeneration |
| Investigator(s): | Ellis-Behnke RG |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2009 |
| Researcher : FUNG TM |
| List of Research Outputs |
| FUNG T.M., Identification, functional characterization and clinical relevance of neuropilin-2 (NRP2) in esophageal squamous cell carcinoma, 2015, 138 pages. |
| Tong M., Fung T.M., Luk T.C.S., Ng K.Y., Lee K.W., Lin C., Yam J.W.P., Chan K.W., Ng F., Zheng B., Yuan Y.F., Xie D., Lo C.M., Man K., Guan X. and Ma S.K.Y., ANXA3/JNK Signaling Promotes Self-Renewal and Tumor Growth, and Its Blockade Provides a Therapeutic Target for Hepatocellular Carcinoma, Stem Cell Reports. 2015. |
| Researcher : Feng W |
| Project Title: | Maintenance of Genome Stability 2014; A role of NIRR in replicative stress responses |
| Investigator(s): | Feng W |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2014 |
| Researcher : Fung TM |
| List of Research Outputs |
| FUNG T.M., Identification, functional characterization and clinical relevance of neuropilin-2 (NRP2) in esophageal squamous cell carcinoma, 2015, 138 pages. |
| Tong M., Fung T.M., Luk T.C.S., Ng K.Y., Lee K.W., Lin C., Yam J.W.P., Chan K.W., Ng F., Zheng B., Yuan Y.F., Xie D., Lo C.M., Man K., Guan X. and Ma S.K.Y., ANXA3/JNK Signaling Promotes Self-Renewal and Tumor Growth, and Its Blockade Provides a Therapeutic Target for Hepatocellular Carcinoma, Stem Cell Reports. 2015. |
| Researcher : Gao M |
| List of Research Outputs |
| Gao M., Guo J., Leung G.K.K. and Wu W., Use of self-assembly nanofibre biomaterials for neural repair after injury, In: Maguire R. (ed.), Advances in Nanofibers. Croatia, InTech, 2015. |
| Researcher : HAN L |
| List of Research Outputs |
| Cheung A., HAN L., Li B., Tsao G.S.W., Law S.Y.K., Chan K.W. and Lam A.K.Y., Role of miR-338-5p as a novel modulator of chemoresistannce in esophageal cancer, EACR AACR SIC Conference, June 20-23, Florence Italy. 2015. |
| HAN L., Li B., Tsao G.S.W. and Cheung A., Roles of miR-338-5p in downregulating Id1 and inhibiting chemoresistance, 21st Hong Kong International Cancer Congress, November 21, 2014, Hong Kong.. 2014, No. A16. |
| Li B., HAN L., Chan K.W., Law S., Lam A.K.Y., Tsao G.S.W. and Cheung A., Suppressive effects of Id1-targeting microRNAs in metastasis of esophageal cancer, 21st Hong Kong International Cancer Congress, November 21, 2014, Hong Kong.. 2014, No. A17. |
| Researcher : HE J |
| List of Research Outputs |
| Weng J.Z., Kong M.C.W., Ren L., Karakikes I., Geng L., HE J., Chow M.Z.Y., Mok C.F., Keung W.W.Y., Chow C.H., Leung A.Y.H., Hajjar R.J., Li R.A. and Chan C.W.Y., A simple, cost-effective but highly efficient system for deriving ventricular cardiomyocytes from human pluripotent stem cells. PMID: 24564569 , Stem Cells & Development. 2014, 23(14): 1704-16. |
| Researcher : Hau PM |
| List of Research Outputs |
| Deng W., ZHOU Y., Tiwari A.F.Y., Su H., Yang J., ZHU D., LAU M.Y., Hau P.M., Yip Y.L., Cheung A., Guan X. and Tsao G.S.W., p21/Cyclin E pathway modulates anticlastogenic function of Bmi-1 in cancer cells., International Journal of Cancer. 2015, 136: 1361-1370. |
| Hau P.M., Deng W., Jia L.J., YANG J., Tsurumi T., Chiang A.K.S., Huen M.S.Y. and Tsao G.S.W., Role of ATM in the formation of the replication compartment during lytic replication of Epstein-Barr virus in nasopharyngeal epithelial cells, Journal of Virology. 2015, 89: 652-668. |
| Yang J., Deng W., Hau P.M., LIU J., LAU M.Y., Cheung A., Huen M.S.Y. and Tsao G.S.W., Epstein-Barr virus BZLF1 protein impairs accumulation of host DNA damage proteins at damage sites in response to DNA damage, Laboratory Investigation. 2015. |
| Researcher : Ho SP |
| List of Research Outputs |
| Hui W.S., Ho S.P., Wong A.T., Ho P.L. and Mak J.C.W., Cellular signaling pathways of matrix metalloproteinase gene expression by Pseudomonas aeruginosa-infected human bronchial epithelial cells, Hong Kong Med J. 2014, 20: 14-17. |
| Researcher : Ho YS |
| List of Research Outputs |
| HUANG C., Ho Y.S., Ng T.W., Irwin M.G., Chang R.C.C. and Wong G.T.C., Dexmedetomidine directly increases tau phosphorylation, Journal of Alzheimer's Disease. 2015, 44: 839-850. |
| Ho W.L., LEUNG Y., CHENG S.Y., Lok C.K.M., Ho Y.S., Baum L., Yang X., Chiu K. and Chang R.C.C., Investigating degeneration of the retina in young and aged tau P301L mice, Life Science. 2015, 124: 16-23. |
| YOU R., CHENG S.Y., Hung C.H.L., Ho Y.S. and Chang R.C.C., Investigating the effects of FITC-tagged SiO2-NPs on tau and synaptic protein in primary culture of cortical neurons, The 10th International Symposium on Healthy Aging. 2015. |
| Researcher : Huen M.S.Y. |
| Project Title: | Molecular and functional characterisation of USP34, a ubiquitin specific peptidase involved in the DNA Damage Response |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2011 |
| Completion Date: | 08/2014 |
| Project Title: | Role of ATM Signaling in PALB2-dependent Homologous Recombination DNA Repair |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 10/2012 |
| Project Title: | Molecular and Functional Characterisation of DYRK1A in DNA Damage Signaling and Repair |
| Investigator(s): | Huen MSY, Sy MH |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2013 |
| Project Title: | Study of the PALB2-Plk1 module in Cell Cycle Checkpoint Control and Maintenance of Genome Stability |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2014 |
| Project Title: | Study Role of PCNA-binding protein TRAIP in Replicative Stress Responses and Tumor Suppression |
| Investigator(s): | Huen MSY, Feng W |
| Department: | Anatomy |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2014 |
| Project Title: | Examining Negative Regulatory Mechanisms of DNA Damage Signal Transduction & Their Impact on Maintenance of Genome Stability |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Keystone Symposia: Genomic Instability and DNA Repair; A PCNA clamp unloader at stressed replication forks |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2015 |
| Completion Date: | 03/2015 |
| Project Title: | Role of UBE2U in DNA Damage Signaling and Repair |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Researcher : Huen MSY |
| Project Title: | Molecular and functional characterisation of USP34, a ubiquitin specific peptidase involved in the DNA Damage Response |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2011 |
| Completion Date: | 08/2014 |
| Project Title: | Role of ATM Signaling in PALB2-dependent Homologous Recombination DNA Repair |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 10/2012 |
| Project Title: | Molecular and Functional Characterisation of DYRK1A in DNA Damage Signaling and Repair |
| Investigator(s): | Huen MSY, Sy MH |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2013 |
| Project Title: | Study of the PALB2-Plk1 module in Cell Cycle Checkpoint Control and Maintenance of Genome Stability |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2014 |
| Project Title: | Study Role of PCNA-binding protein TRAIP in Replicative Stress Responses and Tumor Suppression |
| Investigator(s): | Huen MSY, Feng W |
| Department: | Anatomy |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2014 |
| Project Title: | Examining Negative Regulatory Mechanisms of DNA Damage Signal Transduction & Their Impact on Maintenance of Genome Stability |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Keystone Symposia: Genomic Instability and DNA Repair; A PCNA clamp unloader at stressed replication forks |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2015 |
| Completion Date: | 03/2015 |
| Project Title: | Role of UBE2U in DNA Damage Signaling and Repair |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Chen H., Wang G., Xia J., Zhou Y., Gao Y., Xu J., Huen M.S.Y., Siok W.T., Jiang Y., Tan L.H. and Sun Y., Stuttering candidate genes DRD2 but not SLC6A3 is associated with developmental dyslexia in Chinese population., Behavioral and Brain Functions. 2014, 10: 29-38. |
| Dong S., Han J., Chen H., Liu T., Huen M.S.Y., Yang Y., Guo C. and Huang J., The human SRCAP chromatin remodeling complex promotes DNA-end resection, Current Biology. 2014, 24 (18): 2097-110. |
| Hau P.M., Deng W., Jia L.J., YANG J., Tsurumi T., Chiang A.K.S., Huen M.S.Y. and Tsao G.S.W., Role of ATM in the formation of the replication compartment during lytic replication of Epstein-Barr virus in nasopharyngeal epithelial cells, Journal of Virology. 2015, 89: 652-668. |
| Hodge C.D., Edwards R.A., Markin C.J., McDonald D., Pulvino M.S.Y., Huen M.S.Y., Zhao J., Spyracopoulos L., Hendzel M.J. and Glover J.N., Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting, ACS Chem Biol. 2015. |
| Huen M.S.Y., A PCNA clamp unloader at stressed replication forks, Keystone Symposia - Genomic Instability and DNA Repair, Whistler, Canada. 2015. |
| Huen M.S.Y., From DNA damage to chromatin modifications and DNA repair – Right place, Right time, Right dose., Life Sciences Institute, Zhejiang University, China. 2015. |
| Huen M.S.Y., From DNA damage to chromatin modifications and DNA repair – Right place, Right time, Right dose, LIFS Seminar, Division of Life Science, Hong Kong University of Science and Technology. 2015. |
| Huen M.S.Y., Roles of ubiquitin machineries in DNA damage responses and genome stability maintenance, Department of Chemical Pathology, Chinese University of Hong Kong. 2015. |
| Huen M.S.Y., Roles of ubiquitin machineries in DNA damage responses and genome stability maintenance, Department of Clinical Oncology, University of Hong Kong. 2014. |
| Huen M.S.Y., Roles of ubiquitin machineries in DNA damage signaling and repair, Gordon Research Conference: Genomic Instability: Mechanisms that Cause DNA Damage and Related Diseases. 2014. |
| Sun Y., Hao Y., Zhou Y., Chen H., Wang G., Xu J., Xia J., Huen M.S.Y., Siok W.T., Jiang Y. and Tan L.H., Association study of developmental dyslexia candidate genes DCDC2 and KIAA0319 in Chinese population, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2014, 165B: 627-634. |
| Yang J., Deng W., Hau P.M., LIU J., LAU M.Y., Cheung A., Huen M.S.Y. and Tsao G.S.W., Epstein-Barr virus BZLF1 protein impairs accumulation of host DNA damage proteins at damage sites in response to DNA damage, Laboratory Investigation. 2015. |
| Researcher : Hugon J |
| Project Title: | Society for Neuroscience 30th Annual Meeting Tau Phosphorylation during neuronal Apoptosis Induced by NMDA Receptor Blockade: an in Vivo Study |
| Investigator(s): | Hugon J |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2000 |
| List of Research Outputs |
| Carret A., Pace C.H.L., Gourmaud S., Ravasi L., Montagne-Stora S., Longueville S., Tible M., Sudol E., Chang R.C.C., Paquet C., Mouton-Liger F. and Hugon J., Neuroinflammation and Abeta accumulation linked to systemic inflammation are decreased b genetic PKR down-regulation, Science Report. 2015, 5: 8489. |
| Researcher : Hung CHL |
| List of Research Outputs |
| Chang R.C.C., WONG T.H.G., TSANG A.W.-.T., Hung C.H.L., CHENG S.Y. and Law A.C.K., Evaluation of microtubules and tau in corticosterone-induced depression, similar pathological processes as in beta-amyloid peptide neurotoxicity., The 12th International Conference on Alzheimer's and Parkinson's Diseases. 2015. |
| Ho Y.S., Li X.A., Hung C.H.L. and Chang R.C.C., Prevention of neurodegeneration for Alzheimer's disease by Lycium barbarum, In: Raymond Chuen-Chung Chang & Kwok-Fai So, Lycium barbarum and Human Health. Dordrecht, Springer, 2015, Chapter 7: 99-111. |
| YOU R., CHENG S.Y., Hung C.H.L., Ho Y.S. and Chang R.C.C., Investigating the effects of FITC-tagged SiO2-NPs on tau and synaptic protein in primary culture of cortical neurons, The 10th International Symposium on Healthy Aging. 2015. |
| Researcher : Hung WY |
| List of Research Outputs |
| Lai W.L., Hung W.Y. and Ching Y.P., The tumor suppressor, TAX1BP2, is a novel substrate of ATM kinase, Oncogene. Macmillan Publishers Limited, 2014, 33: 5303-5309. |
| Researcher : Jia LJ |
| Project Title: | To evaluate the functional significance of transcriptome changes upon Epstein-Barr virus infection in starvation-resistant growth of nasopharyngeal epithelial cells. |
| Investigator(s): | Jia LJ, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2014 |
| Project Title: | AACR Annual Meeting 2015; Establishment and characterization of immortalized nasopharyngeal epithelial cells with stable infection of Epstein-Barr virus |
| Investigator(s): | Jia LJ |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2015 |
| Completion Date: | 04/2015 |
| List of Research Outputs |
| Hau P.M., Deng W., Jia L.J., YANG J., Tsurumi T., Chiang A.K.S., Huen M.S.Y. and Tsao G.S.W., Role of ATM in the formation of the replication compartment during lytic replication of Epstein-Barr virus in nasopharyngeal epithelial cells, Journal of Virology. 2015, 89: 652-668. |
| Researcher : KWAN KK |
| List of Research Outputs |
| KWAN K.K., The role of PAK4 in extracellular matrix degradation, 2014, 86 pages. |
| Researcher : LAU MY |
| List of Research Outputs |
| Deng W., ZHOU Y., Tiwari A.F.Y., Su H., Yang J., ZHU D., LAU M.Y., Hau P.M., Yip Y.L., Cheung A., Guan X. and Tsao G.S.W., p21/Cyclin E pathway modulates anticlastogenic function of Bmi-1 in cancer cells., International Journal of Cancer. 2015, 136: 1361-1370. |
| Yang J., Deng W., Hau P.M., LIU J., LAU M.Y., Cheung A., Huen M.S.Y. and Tsao G.S.W., Epstein-Barr virus BZLF1 protein impairs accumulation of host DNA damage proteins at damage sites in response to DNA damage, Laboratory Investigation. 2015. |
| Researcher : LEE CD |
| List of Research Outputs |
| LEE C.D., Study of gliogenesis and neurochemistry underlying psychomotor retardation induced by chronic stress and the therapeutic approach of motor training in reversing the adverse effects, 2014, 207 pages. |
| Researcher : LEUNG KKG |
| List of Research Outputs |
| LEUNG K.K.G., Applications of self-assembling peptide nanofibre scaffold and mesenchymal stem cell graft in surgery-induced brain injury, 2014, 111 pages. |
| Researcher : LEUNG Y |
| List of Research Outputs |
| Ho W.L., LEUNG Y., CHENG S.Y., Lok C.K.M., Ho Y.S., Baum L., Yang X., Chiu K. and Chang R.C.C., Investigating degeneration of the retina in young and aged tau P301L mice, Life Science. 2015, 124: 16-23. |
| LEUNG Y., Evaluating appropriateness for the use of 6-hydroxydopamine as an experimental model for Parkinson's disease to investigate involvement of the Tau protein in cognitive dysfunctions of Parkinson's disease, 2015, 89 pages. |
| Researcher : LI X |
| List of Research Outputs |
| LI X., The role of retino-raphe projection in light therapy for non-seasonal depression, 2014, 172 pages. |
| Researcher : LIU J |
| List of Research Outputs |
| Yang J., Deng W., Hau P.M., LIU J., LAU M.Y., Cheung A., Huen M.S.Y. and Tsao G.S.W., Epstein-Barr virus BZLF1 protein impairs accumulation of host DNA damage proteins at damage sites in response to DNA damage, Laboratory Investigation. 2015. |
| Researcher : LIU KL |
| List of Research Outputs |
| LIU K.L., Chang R.C.C., Pearce R.K.B.B. and Gentleman S.M., Differential pattern of neuronal loss in the cholinergic basal forebrain in Lewy body disorders., The 12th International Conference on Alzheimer's and Parkinson's Diseases. 2015. |
| LIU K.L., Chang R.C.C., Pearce R.K. and Gentleman S.M., Friedrich Lewy's Nucleus basalis of Meynert revisited: anatomy, history and differential involvement in Alzheimer's and Parkinson's disease, Acta Neuropathologie. 2015, 129: 527-540. |
| LIU K.L., Chang R.C.C., Pearce R.K.B.B. and Gentleman S.M., Subregional nucleus basalis of Meynert pathology in Lewy body disorders, The 116th Meeting of the British Neuropathological Society. 2015. |
| LIU K.L., Chang R.C.C., Pearce R.K.B. and Gentleman S.M., Where is the human nucleus basalis of Meynert?, The 116th Meeting of the British Neuropathological Society. 2015. |
| Researcher : Lai WL |
| Project Title: | An investigation on the role of Tax1 binding protein 2 in the DNA damage response in hepatocellular carcinoma |
| Investigator(s): | Lai WL, Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2013 |
| Completion Date: | 11/2014 |
| List of Research Outputs |
| Lai W.L., Hung W.Y. and Ching Y.P., The tumor suppressor, TAX1BP2, is a novel substrate of ATM kinase, Oncogene. Macmillan Publishers Limited, 2014, 33: 5303-5309. |
| Researcher : Lau WM |
| List of Research Outputs |
| So K.F., Chang R.C.C., Lau W.M., Leung C.P. and Po K.T., Prosexual Effects of Lycium Barbarum, Lycium Barbarum and Human Health. London, Springer, 2015, 1-18. |
| Researcher : Li B |
| Project Title: | Suppressive effects of Id1-targeting microRNAs in metastasis of esophageal cancer |
| Investigator(s): | Li B, Cheung A |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2013 |
| Completion Date: | 11/2014 |
| List of Research Outputs |
| Cheung A., XU W., Li B., Tsao G.S.W. and Chan K.W., Role of Id1-IGF2-VEGF-VEGFR relay in esophageal tumorigenesis, 23rd Biennial Congress of the European Association for Cancer Research, July 5-8, 2014 Munich, Germany.. 2014, 50 suppl. 5: S35 No. 161. |
| Cheung A., HAN L., Li B., Tsao G.S.W., Law S.Y.K., Chan K.W. and Lam A.K.Y., Role of miR-338-5p as a novel modulator of chemoresistannce in esophageal cancer, EACR AACR SIC Conference, June 20-23, Florence Italy. 2015. |
| HAN L., Li B., Tsao G.S.W. and Cheung A., Roles of miR-338-5p in downregulating Id1 and inhibiting chemoresistance, 21st Hong Kong International Cancer Congress, November 21, 2014, Hong Kong.. 2014, No. A16. |
| Li B., XU W., Guan X., Law S.Y.K., Tsao G.S.W. and Cheung A., Suppression of esophageal tumor growth and chemoresistance by directly targeting the PI3K/AKT pathway, 2014 World Cancer Congress,December 3-6, Melbourne, Australia.. 2014, Abstract No. 1196. |
| Li B., Li J., Xu W., Guan X., Qin Y.R., Zhang L., Law S.Y.K., Tsao G.S.W. and Cheung A., Suppression of esophageal tumor growth and chemoresistance by directly targeting the PI3K/AKT pathway, Oncotarget. 2014, 5(22): 11576-11587. |
| Li B., HAN L., Chan K.W., Law S., Lam A.K.Y., Tsao G.S.W. and Cheung A., Suppressive effects of Id1-targeting microRNAs in metastasis of esophageal cancer, 21st Hong Kong International Cancer Congress, November 21, 2014, Hong Kong.. 2014, No. A17. |
| XU W., Li B., Li Y.Y., Tsao G.S.W. and Cheung A., Blocking the PI3K/AKT pathway can impair metastasis of esophageal cancer, 2014 World Cancer Congress, December 3-6, 2014, Melbourne, Australia.. 2014, Abstract No. 942. |
| XU W., Li B., Tsao G.S.W., Chan K.W. and Cheung A., IGI-induced IGF2 promotes esophageal cancer progression through instigation of stromal fibroblasts and bone marrow-drived vancular progenitor cells, 21st Hong Kong International Cancer Congress, November 21, 2014 Hong Kong. 2014, No. A11. |
| XU W., Li B., Lam A.K.Y., Tsao G.S.W., Law S.Y.K., Chan K.W., Yuan Q. and Cheung A., Targeting VEGFR-1 and VEGFR2-expressing non-tumor cells is essential for esophageal cancer therapy, Oncotarget. 2014, 6(3): 1790-1805. |
| XU W., Li B. and Cheung A., The potential of targeted antiangiogenesis therapies in the treatment of esophageal cancer, Gastrointestinal Cancer: Targets and Therapy. 2015, 5: 79-88. |
| Xu W.W., Li B., Lai E.T.C., Chen L., Huang J.J.H., Cheung A. and Cheung P.C.K., Water extract from Pleurotus pulmonarius with antioxidant activity exerts in vivo chemoprophylaxis and chemosensitization for liver cancer, Nutrition and Cancer. 2014, 66(6): 989-998. |
| Researcher : Li H |
| List of Research Outputs |
| So K.F., Li H., Chiu K., Chiu K., Chan H.H.L., Chang R.C.C., Kau W.F. and Ruan Y.W., Effect of Lycium barbarum (Wolfberry) on Alleviating Axonal Degeneration After Partial Optic Nerve Transection, Cell Transplantation. USA, Cognizant Comm. Corp., 2015, 24: 403-417. |
| Researcher : Li YY |
| List of Research Outputs |
| XU W., Li B., Li Y.Y., Tsao G.S.W. and Cheung A., Blocking the PI3K/AKT pathway can impair metastasis of esophageal cancer, 2014 World Cancer Congress, December 3-6, 2014, Melbourne, Australia.. 2014, Abstract No. 942. |
| Researcher : Liang Y |
| List of Research Outputs |
| Liang Y., Yang J., Yuan T.F. and So K.F., Uptake of Retrograde Tracers by Intact Optic Nerve Axons: A New Way to Label Retinal Ganglion Cells, PLOS ONE. 2015, 10: e0128718. |
| Yuan T.F., Liang Y., PENG B., Lin B. and So K.F., Local proliferation is the main source of rod microglia after optic nerve transection, Scientific Reports. 2015, 5: 10788. |
| Yuan T.F., Liang Y. and So K.F., Response: New neurons from old beliefs in the adult piriform cortex? A Commentary on: "Occurrence of new neurons in the piriform cortex", Frontiers in Neuroanatomy. 2015, 9: 79. |
| Yuan T.F., Liang Y., Tay D., So K.F. and Ellis-Behnke R., Specialized Vasculature in the Rostral Migratory Stream as a Neurogenic Niche and Scaffold for Neuroblast Migration, Cell Transplantation. 2015, 24: 377-390. |
| Researcher : Lin B |
| Project Title: | The role of gap junctions in retinal degeneration |
| Investigator(s): | Lin B |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2013 |
| Project Title: | Modulation of the PTEN/mTOR pathway enhances the survival of cone photoreceptors in retinal degeneration disorders |
| Investigator(s): | Lin B, Ching YP, Huang X |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 12/2013 |
| Project Title: | Cyclooxygenase-1 deletion enhances cone photoreceptor survival in retinal degeneration disorders |
| Investigator(s): | Lin B |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Ectopic expression of the light-sensitive protein melanopsin in rod photoreceptors prevents retinal degeneration |
| Investigator(s): | Lin B |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Cyclooxygenase-1 deletion promotes microglia quiescence and enhances cone photoreceptor survival in retinal degeneration disorders |
| Investigator(s): | Lin B, Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2015 |
| Project Title: | Inhibition of colony-stimulating factor 1 receptor signaling in microglia delays the progression of the chronic neurodegeneration in retinitis pigmentosa |
| Investigator(s): | Lin B |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Wang K., Xiao J., PENG B., Xing F., So K.F., Tipoe G.L. and Lin B., Retinal structure and function preservation by polysaccharides of wolfberry in a mouse model of retinal degeneration, Scientific Reports. 2014, 4:7601; DOI:10.1038/srep07601. |
| Yuan T.F., Liang Y., PENG B., Lin B. and So K.F., Local proliferation is the main source of rod microglia after optic nerve transection, Scientific Reports. 2015, 5: 10788. |
| Researcher : Ling MT |
| Project Title: | The regulation and role of Id-1 in prostate cancer progression |
| Investigator(s): | Ling MT, Wong YC, Wang X |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2005 |
| Project Title: | The role of EMI1 in prostate carcinogenesis |
| Investigator(s): | Ling MT, Wang X |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 02/2007 |
| Project Title: | The role of Daxx in chromosome instability and prostate carcinogenesis |
| Investigator(s): | Ling MT, Wong YC |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2008 |
| Project Title: | Effect of Tocotrienol in the inhibition of hormone refractory prostate cancer |
| Investigator(s): | Ling MT, Wong YC |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 08/2008 |
| Researcher : Liong EC |
| List of Research Outputs |
| Guo R., Liong E.C., So K.F., Fung M.L. and Tipoe G.L., Beneficial mechanisms of aerobic exercise on hepatic lipid metabolism in non-alcoholic fatty liver disease, Hepatobiliary Pancreatic Diseases International. 2015, 14: 139-144. |
| Pan J., Guo R., Liong E.C., Tipoe G.L. and Fung M.L., Apocynin attenuates the oxidative stress and inflammation induced by palmitate and intermittent hypoxia in HepG2 cells. The 8th Pong Ding Yuen International Symposium on Traditional Chinese medicine cum The 2nd International Chinese Symposium on Free Radical Research , The 6th Symposium for Three Districts of Cross-straits on Free Radical Research, HK 11/2014. |
| Pan J., Guo R., Liong E.C., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia aggravates oxidative stress, inflammation and apoptosis in non-alcoholic fatty liver disease, 19th Research Postgraduate Symposium, HKU P7.01. 2014. |
| Pan J., Guo R., Liong E.C., Tipoe G.L. and Fung M.L., Intermittent hypoxia aggravates early pathogenesis of non-alcoholic fatty liver disease in rats. The 18thAnnual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, Journal of the Hong Kong College of Cardiology CP6. 2014, 22(2): 54. |
| Pan J., Guo R., Liong E.C., Tipoe G.L. and Fung M.L., Intermittent hypoxia-induced oxidative stress aggravates inflammation induced by palmitate via Toll-like receptor 4 in a cell model of non-alcoholic fatty liver disease, The 1st European Fatty Liver Conference, Masstricht (the Netherlands) 3/2015. |
| Xiao J., Liong E.C., Huang H., Tse W.O., Lau K.S., Pan J., Nanji A.A., Fung M.L., Xing F. and Tipoe G.L., Cycloxygenase-1 serves a vital hepato-protective function in chemically induced acute liver injury, Toxicological Sciences. 2015, 143(2): 430-440. |
| Xiao J., Xing F., Huo J., Fung M.L., Liong E.C., Ching Y.P., Xu A., Chang R.C.C., So K.F. and Tipoe G.L., Lycium barbarum polysaccharides therapeutically improve hepatic functions in non-alcoholic steatohepatitis rats and cellular steatosis model, Scientific Reports. 2014, 4: 5587. |
| Researcher : Lok CKM |
| List of Research Outputs |
| Ho W.L., LEUNG Y., CHENG S.Y., Lok C.K.M., Ho Y.S., Baum L., Yang X., Chiu K. and Chang R.C.C., Investigating degeneration of the retina in young and aged tau P301L mice, Life Science. 2015, 124: 16-23. |
| Researcher : Luk TCS |
| List of Research Outputs |
| Tong M., Fung T.M., Luk T.C.S., Ng K.Y., Lee K.W., Lin C., Yam J.W.P., Chan K.W., Ng F., Zheng B., Yuan Y.F., Xie D., Lo C.M., Man K., Guan X. and Ma S.K.Y., ANXA3/JNK Signaling Promotes Self-Renewal and Tumor Growth, and Its Blockade Provides a Therapeutic Target for Hepatocellular Carcinoma, Stem Cell Reports. 2015. |
| Researcher : Ma SKY |
| Project Title: | Centre for MicroRNA Study - Basic Research and Clinical Potentials in Cancer |
| Investigator(s): | Ma SKY, Wong AST |
| Department: | Pathology |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 06/2012 |
| Project Title: | Characterization and clinical evaluation of the metastasis-suppressing function of TP53INP1 in hepatocellular carcinoma |
| Investigator(s): | Ma SKY |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2012 |
| Project Title: | Hepatitis B virus promotes hepatocarcinogenesis through induction of CD133+ cancer stem cells/tumor-initiating cells |
| Investigator(s): | Ma SKY, Guan X |
| Department: | Clinical Oncology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 01/2013 |
| Project Title: | Significance of Annexin A3 in CD133+ Cancer-Initiating Cells-Driven Hepatocellular Carcinoma |
| Investigator(s): | Ma SKY, Chan KW |
| Department: | Clinical Oncology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2013 |
| Project Title: | Outstanding Young Researcher Award 2012-13 |
| Investigator(s): | Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 01/2014 |
| Project Title: | A multidisciplinary study on hepatic cancer stem cells |
| Investigator(s): | Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Croucher Innovation Awards |
| Start Date: | 04/2014 |
| Project Title: | The use of anti-annexin A3 monoclonal antibody for the treatment of liver cancer |
| Investigator(s): | Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 05/2014 |
| Completion Date: | 04/2015 |
| Project Title: | miR-1246 and Wnt/β-catenin interaction in the control of CD133+ liver cancer stem cells driven hepatocellular carcinoma |
| Investigator(s): | Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Regulatory role of microRNA-1246 and Wnt/?catenin pathway interaction in CD133+ liver cancer stem cells-driven hepatocellular carcinoma |
| Investigator(s): | Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 01/2015 |
| Project Title: | PRMT6 in the control of glucose metabolic reprogramming in CD133+ liver cancer stem cells |
| Investigator(s): | Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2015 |
| Project Title: | A Multidisciplinary Study on CD133 Liver Cancer Stem Cells: Molecular Mechanisms, Clinical Relevance and Therapeutic Implications |
| Investigator(s): | Ma SKY, Guan X, Lo CM, Man K |
| Department: | Anatomy |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Chan L.H., Luk S.T. and Ma S.K.Y., Turning hepatic cancer stem cells inside out – a deeper understanding through multiple perspectives, Molecules and Cells. 2015, 38: 202-9. |
| Lee K.W., Cheung C.H., Lu P., LAU Y.T., Ma S.K.Y., TANG K.H., Tong M., LO J. and Ng I.O.L., Blockade of CD47 mediated CTSS-PAR2 signaling provides a therapeutic target for hepatocellular carcinoma, Hepatology. 2014, 60: 179-191. |
| Ma S.K.Y., Cancer stem cells in the development of hepatocellular carcinoma - CD133 and beyond, 2014 International Symposium for Recent Advances in Cancer - Hepatocellular Carcinoma, Taipei Medical University, Taipei, Taiwan. 2014. |
| Ma S.K.Y., Targeting liver cancer stem cells - hype or hope?, The 5th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2014), Taipei, Taiwan. 2014. |
| SONG Y., Pan G., Chen L., Ma S.K.Y., Zeng T., Chan T.H., Li L., Lian Q., CHOW K.K., Cai X., Li Y., Li Y., Liu M., LI Y., Zhu Y., Wong N., Yuan Y.F., Pei D. and Guan X., Loss of ATOH8 increases stem cell features of hepatocellular carcinoma cells, Gastroenterology. 2015. |
| Tang K.D., Holzapfel N.M., Liu J., Lee K.W., Ma S.K.Y., Jovanovix L., An J., Russell P.J., Hutmacher D.W. and Ling M.T., Tie-2 regulates the stemness and metastatic properties of prostate cancer cells. , Oncotarget. 2015. |
| Tong M., Fung T.M., Luk T.C.S., Ng K.Y., Lee K.W., Lin C., Yam J.W.P., Chan K.W., Ng F., Zheng B., Yuan Y.F., Xie D., Lo C.M., Man K., Guan X. and Ma S.K.Y., ANXA3/JNK Signaling Promotes Self-Renewal and Tumor Growth, and Its Blockade Provides a Therapeutic Target for Hepatocellular Carcinoma, Stem Cell Reports. 2015. |
| Researcher : Mi X |
| List of Research Outputs |
| Mi X., Yuan T., Ding Y., Zhong J. and So K.F., Choosing preclinical study models of diabetic retinopathy: key problems for consideration, Drug Design, Development and Therapy. 2014, 8: 2311-2319. |
| Mi X., Yuan T. and So K.F., The current research status of normal tension glaucoma, Clinical Interventions in Aging. 2014. |
| Researcher : Ng KY |
| Project Title: | AACR Annual Meeting 2015; C-terminal truncated hepatitis B virus X protein promotes hepatocarcinogenesis through enhanced stemness and resistance to therapy |
| Investigator(s): | Ng KY |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2015 |
| Project Title: | Role of LOXL1 in CD133+ liver cancer stem cells driven hepatocellular carcinoma |
| Investigator(s): | Ng KY, Huen MSY, Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2015 |
| List of Research Outputs |
| Tong M., Fung T.M., Luk T.C.S., Ng K.Y., Lee K.W., Lin C., Yam J.W.P., Chan K.W., Ng F., Zheng B., Yuan Y.F., Xie D., Lo C.M., Man K., Guan X. and Ma S.K.Y., ANXA3/JNK Signaling Promotes Self-Renewal and Tumor Growth, and Its Blockade Provides a Therapeutic Target for Hepatocellular Carcinoma, Stem Cell Reports. 2015. |
| Researcher : Ng TW |
| Project Title: | Evaluating the effect of prostaglandin-E2 EP4 receptor signaling |
| Investigator(s): | Ng TW, Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 04/2015 |
| List of Research Outputs |
| HUANG C., Ng T.W., Chu M.T., Chang R.C.C. and Wong G.T.C., Correlation between tau hyperphosphorylation and inflammation in post operative cognitive dysfunction, International Alzheimer’s Disease Conference 2015. |
| HUANG C., Ho Y.S., Ng T.W., Irwin M.G., Chang R.C.C. and Wong G.T.C., Dexmedetomidine directly increases tau phosphorylation, Journal of Alzheimer's Disease. 2015, 44: 839-850. |
| Ng T.W., HUANG C., Lau C.F., Wong G.T.C. and Chang R.C.C., The potential impact of anaesthesia induced synaptic proteins changes on post-operative cognitive dysfunction (POCD), International Alzheimer’s Disease Conference 2015. |
| Researcher : O WS |
| List of Research Outputs |
| Wong P.F., Cheung M.P.L., O W.S. and Tang F., Intermedin inhibits norepinephrine - induced contraction of rat seminal vesicle, Asia Pacific Journal of Reproduction. 2014, 3(3): 176-179. |
| Researcher : PAN Y |
| List of Research Outputs |
| PAN Y., GSK-3b inhibition promotes oligodendroglial differentiation and remyelination after spinal cord injury, 2015, 100 pages. |
| PAN Y., DAI Y., Cheung M.P.L. and Yip H.K.F., The Inhibition Of GSK3β Promotes Oligodendroglial Progenitor Cell Differentiation In Spinal Cord Injury, Federation Of European Neuroscience Societies Annual Meeting. 2014. |
| PAN Y., DAI Y. and Yip H.K.F., The Role of GSK3β Pathway in Oligodendroglial Progenitor Cell (OPC) Differentiation and Remyelination after Spinal Cord Injury (SCI), 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2014. |
| Researcher : PENG B |
| List of Research Outputs |
| Wang K., Xiao J., PENG B., Xing F., So K.F., Tipoe G.L. and Lin B., Retinal structure and function preservation by polysaccharides of wolfberry in a mouse model of retinal degeneration, Scientific Reports. 2014, 4:7601; DOI:10.1038/srep07601. |
| Yuan T.F., Liang Y., PENG B., Lin B. and So K.F., Local proliferation is the main source of rod microglia after optic nerve transection, Scientific Reports. 2015, 5: 10788. |
| Researcher : POON CH |
| List of Research Outputs |
| POON C.H., Investigating the roles of protein kinase R (PKR) to modulate the effects of systemic inflammation on the brain, 2015, 182 pages. |
| Researcher : Pu M |
| List of Research Outputs |
| So K.F., Pu M., Ren C. and Cui Q., Dendritic Morphology of Caudal Periaqueductal Gray Projecting Retinal Ganglion Cells in Mongolian Gerbil (Meriones unguiculatus) , PLOS ONE. 2014, 9(7): 1-11. |
| Researcher : QI C |
| List of Research Outputs |
| QI C., Effects of notoginsenoside R1 against glutamate neurotoxicity in vitro and on mice brain following ischemic stroke in vivo, 2014, 137 pages. |
| Researcher : Ren C |
| List of Research Outputs |
| So K.F., Pu M., Ren C. and Cui Q., Dendritic Morphology of Caudal Periaqueductal Gray Projecting Retinal Ganglion Cells in Mongolian Gerbil (Meriones unguiculatus) , PLOS ONE. 2014, 9(7): 1-11. |
| So K.F., Ren C., Xiao J., Bie M., Lv Y., Xing F.Y. and C Q., Lycium barbarum Polysaccharide Improves Bipolar Pulse Current-Induced Microglia Cell Injury Through Modulating Autophagy, Cell Transplantation. USA, Cognizant Comm. Corp., 2015, 24: 419-428. |
| Researcher : So K.F. |
| Project Title: | Study of gliogenesis and neurochemistry underlying psychomotor retardation induced by chronic stress and the therapeutic approach of motor training in reversing the adverse effects |
| Investigator(s): | So KF |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2013 |
| Completion Date: | 05/2015 |
| Project Title: | Minimizing neuropsychiatric side-effects of glucocorticoid therapy by antipsychotics and Chinese medicine |
| Investigator(s): | So KF, Lee TMC, Chang RCC, Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 01/2014 |
| Project Title: | Potential Role of Adiponectin Signaling in Mediating Physical Exercise-Elicited Hippocampal Neurogenesis and Antidepressive Effects in Stressed Mice |
| Investigator(s): | So KF, Xu A |
| Department: | Ophthalmology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| Project Title: | Study of gliogenesis and neurochemistry underlying psychomotor retardation induced by chronic stress and the therapeutic approach for motor training in reversing the adverse effects |
| Investigator(s): | So KF, Wu W, Lee TMC |
| Department: | Ophthalmology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| List of Research Outputs |
| Researcher : So KF |
| Project Title: | Study of gliogenesis and neurochemistry underlying psychomotor retardation induced by chronic stress and the therapeutic approach of motor training in reversing the adverse effects |
| Investigator(s): | So KF |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2013 |
| Completion Date: | 05/2015 |
| Project Title: | Minimizing neuropsychiatric side-effects of glucocorticoid therapy by antipsychotics and Chinese medicine |
| Investigator(s): | So KF, Lee TMC, Chang RCC, Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 01/2014 |
| Project Title: | Potential Role of Adiponectin Signaling in Mediating Physical Exercise-Elicited Hippocampal Neurogenesis and Antidepressive Effects in Stressed Mice |
| Investigator(s): | So KF, Xu A |
| Department: | Ophthalmology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| Project Title: | Study of gliogenesis and neurochemistry underlying psychomotor retardation induced by chronic stress and the therapeutic approach for motor training in reversing the adverse effects |
| Investigator(s): | So KF, Wu W, Lee TMC |
| Department: | Ophthalmology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| List of Research Outputs |
| Bie M., Lv Y., Ren C., Xing F., Cui Q., Xiao J. and So K.F., Lycium barbarum Polysaccharide Improves Bipolar Pulse Current-Induced Microglia Cell Injury Through Modulating Autophagy, Cell Transplantation. 2015, 24: 419-428. |
| Chang R.C.C. and So K.F., In: Raymond Chuen Chung Chang & Kwok-Fai So, Lycium Barbarum and Human Health. Dordrecht, Springer, 2015, 1-198. |
| Ding Y., Qu Y., Feng J., Wang M., Han Q., So K.F., Wu W. and Zhou L., Functional motor recovery from motoneuron axotomy is compromised in mice with defective corticospinal projections, PLOS ONE. 2014, 9(7): e101918. |
| Guo R., Liong E.C., So K.F., Fung M.L. and Tipoe G.L., Beneficial mechanisms of aerobic exercise on hepatic lipid metabolism in non-alcoholic fatty liver disease, Hepatobiliary Pancreatic Diseases International. 2015, 14: 139-144. |
| Han Q., Cao C., Ding Y., So K.F., Wu W., Qu Y. and Zhou L., Plasticity of motor network and function in the absence of corticospinal projection, Experimental Neurology. 2015, 267: 194-208. |
| LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Chan Y.S., Cheung K.H. and Fung M.L., Lycium barbarum polysaccharides antagonized rat hippocampal-dependent spatial memory deficits induced by chronic intermittent hypoxia. The 8th Pong Ding Yuen International Symposium on Traditional Chinese medicine cum The 2nd International Chinese Symposium on Free Radical Research , The 6th Symposium for Three Districts of Cross-straits on Free Radical Research, HK 11/2014. |
| Lam C.S., Tipoe G.L., So K.F. and Fung M.L., Neuroprotective Mechanism of Lycium barbarum Polysaccharides against Hippocampal-Dependent Spatial Memory Deficits in a Rat Model of Obstructive Sleep Apnea, PLOS ONE. 2015, 10: e0117990. |
| Li H.Y., Chan H.H.L., Chu P.H.W., Chang R.C.C. and So K.F., Secondary degeneration after partial optic nerve injury and possible neuroprotective effects of Lycium barbarum (Wolfberry), In: Raymond Chuen-Chung Chang & Kwok-Fai So, Lycium Barbarum and Human Health. Dordrecht, Springer, 2015, Chapter 10: 135-151. |
| Liang Y., Yang J., Yuan T.F. and So K.F., Uptake of Retrograde Tracers by Intact Optic Nerve Axons: A New Way to Label Retinal Ganglion Cells, PLOS ONE. 2015, 10: e0128718. |
| Mi X.S., Huang R.J., Ding Y., Chang R.C.C. and So K.F., Effects of Lycium barbarum on modulation of blood vessel and hemodynamics, In: Raymond Chuen-Chung Chang & Kwok-Fai So, Lycium Barbarum and Human Health. Dordrecht, Springer, 2015, Chapter 4: 65-77. |
| So K.F., Leung M.C.P. and Cui Q., Effects of low level laser treatment on the survival of axotomized retinal ganglion cells in adult hamsters, Neural Regeneration Research. 2014, 9(21): 1863-1869. |
| Xiao J., Xing F., Huo J., Fung M.L., Liong E.C., Ching Y.P., Xu A., Chang R.C.C., So K.F. and Tipoe G.L., Lycium barbarum polysaccharides therapeutically improve hepatic functions in non-alcoholic steatohepatitis rats and cellular steatosis model, Scientific Reports. 2014, 4: 5587. |
| Yau S.Y., LI A., Xu A. and So K.F., Fat cell-secreted adiponectin mediates physical exercise-induced hippocampal neurogenesis: an alternative anti-depressive treatment?, Neural Regeneration Research. 2015. |
| Yuan T., Liang Y. and So K.F., Occurrence of new neurons in the piriform cortex, Frontiers in Neuroanatomy. 2015, 8: 1-5. |
| Yuan T.F., Liang Y., PENG B., Lin B. and So K.F., Local proliferation is the main source of rod microglia after optic nerve transection, Scientific Reports. 2015, 5: 10788. |
| Yuan T.F., Liang Y. and So K.F., Response: New neurons from old beliefs in the adult piriform cortex? A Commentary on: "Occurrence of new neurons in the piriform cortex", Frontiers in Neuroanatomy. 2015, 9: 79. |
| Yuan T.F., Liang Y., Tay D., So K.F. and Ellis-Behnke R., Specialized Vasculature in the Rostral Migratory Stream as a Neurogenic Niche and Scaffold for Neuroblast Migration, Cell Transplantation. 2015, 24: 377-390. |
| Researcher : Sy MH |
| Project Title: | Regulation of Microcephalin (MCPH1) by the Herpes Simplex Virus Type 1 Regulatory Protein ICP0 |
| Investigator(s): | Sy MH, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2013 |
| Project Title: | The role of DNA Damage Response in Genomic Instability Observed in Hepatocellular Carcinoma |
| Investigator(s): | Sy MH, Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2015 |
| Researcher : Sy SMH |
| Project Title: | Regulation of Microcephalin (MCPH1) by the Herpes Simplex Virus Type 1 Regulatory Protein ICP0 |
| Investigator(s): | Sy MH, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2013 |
| Project Title: | The role of DNA Damage Response in Genomic Instability Observed in Hepatocellular Carcinoma |
| Investigator(s): | Sy MH, Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2015 |
| Researcher : TONG M |
| List of Research Outputs |
| Lee K.W., Cheung C.H., Lu P., LAU Y.T., Ma S.K.Y., TANG K.H., Tong M., LO J. and Ng I.O.L., Blockade of CD47 mediated CTSS-PAR2 signaling provides a therapeutic target for hepatocellular carcinoma, Hepatology. 2014, 60: 179-191. |
| TONG M., Clinical relevance, functional significance and therapeutic implication of annexin A3 in CD133+ liver cancer stem cells driven hepatocellular carcinoma, 2015, 214 pages. |
| Tong M., Fung T.M., Luk T.C.S., Ng K.Y., Lee K.W., Lin C., Yam J.W.P., Chan K.W., Ng F., Zheng B., Yuan Y.F., Xie D., Lo C.M., Man K., Guan X. and Ma S.K.Y., ANXA3/JNK Signaling Promotes Self-Renewal and Tumor Growth, and Its Blockade Provides a Therapeutic Target for Hepatocellular Carcinoma, Stem Cell Reports. 2015. |
| Researcher : TSANG AW-T |
| List of Research Outputs |
| Chang R.C.C., WONG T.H.G., TSANG A.W.-.T., Hung C.H.L., CHENG S.Y. and Law A.C.K., Evaluation of microtubules and tau in corticosterone-induced depression, similar pathological processes as in beta-amyloid peptide neurotoxicity., The 12th International Conference on Alzheimer's and Parkinson's Diseases. 2015. |
| Researcher : Tipoe GL |
| Project Title: | Garlic derived S-allylmercaptocysteine (SAMC) reduces apoptosis in non-alcoholic fatty liver disease rat model through p53-dependent pathways |
| Investigator(s): | Tipoe GL |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2013 |
| Completion Date: | 02/2015 |
| Project Title: | 23rd Conference of the Asian Pacific Association for the Study of the Liver (APASL); Polysaccharides from Lycium barbarum attenuates hepatic steatosis, fibrosis and inflammation in non-alcoholic liver diseases (NAFLD) rat model |
| Investigator(s): | Tipoe GL |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2013 |
| Project Title: | Multifunctional M30 drug down-regulates carbon tetrachloride (CCl4) – induced hepatic oxidative stress, inflammation and apoptosis in vitro and in vivo models |
| Investigator(s): | Tipoe GL |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2014 |
| Project Title: | The regulation of cylcooxygenase-1 in a carbon tetrachloride induced acute liver injury animal model |
| Investigator(s): | Tipoe GL |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 04/2015 |
| List of Research Outputs |
| Gao Z., Zhang H., Liu J., Lau C.W., Liu P., Chen Z.Y., L;ee H.K., Tipoe G.L., Ho H.M. and Yao X., Cyclooxygenase-2-dependent oxidative stress mediates palmitate-induced impairment of endothelium-dependent relaxations in mouse arteries, Biochemical Pharmacology. 2014, 91: 474-482. |
| Guo R., Liong E.C., So K.F., Fung M.L. and Tipoe G.L., Beneficial mechanisms of aerobic exercise on hepatic lipid metabolism in non-alcoholic fatty liver disease, Hepatobiliary Pancreatic Diseases International. 2015, 14: 139-144. |
| LAM C.S., Liu Y.Y., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia induces depressive-like behavior in rats. The 18th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, Journal of the Hong Kong College of Cardiology CP8. 2014, 22(2): 55. |
| LAM C.S., LIU Y.Y., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia provokes depressive-like responses in rats, 19th Research Postgraduate Symposium, HKU, P4.01,. 2014. |
| LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Chan Y.S., Cheung K.H. and Fung M.L., Lycium barbarum polysaccharides antagonized rat hippocampal-dependent spatial memory deficits induced by chronic intermittent hypoxia. The 8th Pong Ding Yuen International Symposium on Traditional Chinese medicine cum The 2nd International Chinese Symposium on Free Radical Research , The 6th Symposium for Three Districts of Cross-straits on Free Radical Research, HK 11/2014. |
| LAM C.S., LI J.J., Tipoe G.L. and Fung M.L., Mechanistic roles of monoamine oxidase-A in the induction of depressive-like behavior by chronic intermittent hypoxia in rats, The Tenth International Symposium on Healthy Aging – A Decade of Positive Aging, OP7 3/2015. |
| LI J.J., LAM C.S., Tipoe G.L. and Fung M.L., Intermittent hypoxia increases the expression of monoamine oxidase-A in SH-SY5Y cells, The Tenth International Symposium on Healthy Aging – A Decade of Positive Aging, P40 3/2015. |
| Lam C.S., Tipoe G.L., So K.F. and Fung M.L., Neuroprotective Mechanism of Lycium barbarum Polysaccharides against Hippocampal-Dependent Spatial Memory Deficits in a Rat Model of Obstructive Sleep Apnea, PLOS ONE. 2015, 10: e0117990. |
| Liu Y., Tipoe G.L. and Fung M.L., Melatonin Attenuates Intermittent Hypoxia-Induced Lipid Peroxidation and Local Inflammation in Rat Adrenal Medulla, International Journal of Molecular Sciences. 2014, 15 (10): 18437-18452. |
| Pan J., Guo R., Liong E.C., Tipoe G.L. and Fung M.L., Apocynin attenuates the oxidative stress and inflammation induced by palmitate and intermittent hypoxia in HepG2 cells. The 8th Pong Ding Yuen International Symposium on Traditional Chinese medicine cum The 2nd International Chinese Symposium on Free Radical Research , The 6th Symposium for Three Districts of Cross-straits on Free Radical Research, HK 11/2014. |
| Pan J., Guo R., Liong E.C., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia aggravates oxidative stress, inflammation and apoptosis in non-alcoholic fatty liver disease, 19th Research Postgraduate Symposium, HKU P7.01. 2014. |
| Pan J., Guo R., Liong E.C., Tipoe G.L. and Fung M.L., Intermittent hypoxia aggravates early pathogenesis of non-alcoholic fatty liver disease in rats. The 18thAnnual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, Journal of the Hong Kong College of Cardiology CP6. 2014, 22(2): 54. |
| Pan J., Guo R., Liong E.C., Tipoe G.L. and Fung M.L., Intermittent hypoxia-induced oxidative stress aggravates inflammation induced by palmitate via Toll-like receptor 4 in a cell model of non-alcoholic fatty liver disease, The 1st European Fatty Liver Conference, Masstricht (the Netherlands) 3/2015. |
| Pan J., Guo R., Tipoe G.L. and Fung M.L., NADPH oxidase induced by intermittent hypoxia exacerbates oxidative stress, inflammation and apoptosis in a cell model of non-alcoholic fatty liver disease, The Liver Meeting 2014 American Association for the Study of Liver Diseases, Boston, USA. 2014. |
| Wang H., Sit W.H., Tipoe G.L. and Wang J.M., Differential protective effects of extra virgin olive oil and corn oil in liver injury: A proteomic study, Food and Chemical Toxicology. 2014, 74: 131-138. |
| Wang K., Xiao J., PENG B., Xing F., So K.F., Tipoe G.L. and Lin B., Retinal structure and function preservation by polysaccharides of wolfberry in a mouse model of retinal degeneration, Scientific Reports. 2014, 4:7601; DOI:10.1038/srep07601. |
| Xiao J., Liong E.C., Huang H., Tse W.O., Lau K.S., Pan J., Nanji A.A., Fung M.L., Xing F. and Tipoe G.L., Cycloxygenase-1 serves a vital hepato-protective function in chemically induced acute liver injury, Toxicological Sciences. 2015, 143(2): 430-440. |
| Xiao J., Xing F., Huo J., Fung M.L., Liong E.C., Ching Y.P., Xu A., Chang R.C.C., So K.F. and Tipoe G.L., Lycium barbarum polysaccharides therapeutically improve hepatic functions in non-alcoholic steatohepatitis rats and cellular steatosis model, Scientific Reports. 2014, 4: 5587. |
| Yao K.M., Tipoe G.L. and Vackova D., HKU MBBS Y1 IASM Block, PBL case 2 Ah Fai 2015-2016 (Teaching material PBL case writing), HKU, LKS Faculty of Medicine. 2015. |
| Researcher : Tong M |
| Project Title: | The clinical and functional significances of glucose transporter, isoform 3 (GLUT3) in CD133+ liver cancer stem cells driven Hepatocellular carcinoma |
| Investigator(s): | Tong M, Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2015 |
| Project Title: | American Association for Cancer Research - Annual Meeting 2015; Secretory ANXA3 endows liver cancer cells with tumorigenic and self-renewal abilities and promotes HCC development |
| Investigator(s): | Tong M |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2015 |
| Completion Date: | 04/2015 |
| List of Research Outputs |
| Lee K.W., Cheung C.H., Lu P., LAU Y.T., Ma S.K.Y., TANG K.H., Tong M., LO J. and Ng I.O.L., Blockade of CD47 mediated CTSS-PAR2 signaling provides a therapeutic target for hepatocellular carcinoma, Hepatology. 2014, 60: 179-191. |
| TONG M., Clinical relevance, functional significance and therapeutic implication of annexin A3 in CD133+ liver cancer stem cells driven hepatocellular carcinoma, 2015, 214 pages. |
| Tong M., Fung T.M., Luk T.C.S., Ng K.Y., Lee K.W., Lin C., Yam J.W.P., Chan K.W., Ng F., Zheng B., Yuan Y.F., Xie D., Lo C.M., Man K., Guan X. and Ma S.K.Y., ANXA3/JNK Signaling Promotes Self-Renewal and Tumor Growth, and Its Blockade Provides a Therapeutic Target for Hepatocellular Carcinoma, Stem Cell Reports. 2015. |
| Researcher : Tsang C.M. |
| Project Title: | The biological significance of TGF-β1 in sensitizing the nasopharyngeal epithelial cells to EBV infection |
| Investigator(s): | Tsang CM, Yip YL, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2013 |
| Project Title: | The protective role of Epstein-Barr virus infection towards starvation-induced apoptosis |
| Investigator(s): | Tsang CM, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2014 |
| List of Research Outputs |
| Researcher : Tsang CM |
| Project Title: | The biological significance of TGF-β1 in sensitizing the nasopharyngeal epithelial cells to EBV infection |
| Investigator(s): | Tsang CM, Yip YL, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2013 |
| Project Title: | The protective role of Epstein-Barr virus infection towards starvation-induced apoptosis |
| Investigator(s): | Tsang CM, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2014 |
| List of Research Outputs |
| Tsang C.M., Cheung K.C., Cheung Y.C., Man K., Lui W.Y.V., Feng Y. and Tsao G.S.W., Berberine suppresses Id-1 expression and inhibits the growth and development of lung metastases in hepatocellular carcinoma, Biochimica et Biophysica Acta. 2014, Epub on 2014-12-08. |
| Tsang C.M., Deng W., Yip Y.L., Zeng M.S., Lo K.W. and Tsao G.S.W., Epstein-Barr virus infection and persistence in nasopharyngeal epithelial cells, Chinese Journal of Cancer. 2014, 33: 549-555. |
| Tsao G.S.W., Tsang C.M., Yip Y.L., Lung M.L. and Lo K.W., Biology of EBV infection in nasopharyngeal epithelial cells, 16th International Symposium on EBV and Associated Diseases. Brisbane, Australia. 2014. |
| Researcher : Tsao G.S.W. |
| Project Title: | Cancer |
| Investigator(s): | Tsao GSW, Poon RTP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 11/2008 |
| Project Title: | The role of TGF-beta in EBV infection and pathogenesis of nasopharyngeal carcinoma |
| Investigator(s): | Tsao GSW, Lan HY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2009 |
| Project Title: | The role of cyclin D1 in the persistence of Epstein-Barr virus (EBV) infection in premalignant nasopharyngeal epithelial cells. |
| Investigator(s): | Tsao GSW, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2011 |
| Completion Date: | 09/2014 |
| Project Title: | The role of ATM signaling in the lytic replication of Epstein-Barr virus in infected nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW, Chiang AKS, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Project Title: | Functional interaction of EBV-encoded BZLF1 with the DNA damage repair proteins |
| Investigator(s): | Tsao GSW, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2013 |
| Completion Date: | 04/2015 |
| Project Title: | Systematic Development of Molecular Targets for Nasopharyngeal Carcinoma |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 01/2014 |
| Project Title: | Dynamics of EBV episome maintenance in infected nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW, Chen H, Deng W |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Advances in Live Cell and Intravital Imaging in Biomedicine |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Croucher Foundation - Conference / Seminars |
| Start Date: | 03/2014 |
| Project Title: | Live cell imaging of invasion by EBV-infected nasopharyngeal epithelial cells. |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2014 |
| Project Title: | Regulation of invadopodia formation by the EBV-encoded LMP1 in nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Annual meeting 2015 of American Association for Cancer Research; The role of NF-kB activation in the immortalization of nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2015 |
| Completion Date: | 04/2015 |
| Project Title: | Delineating the signal pathways of LMP1 in the activation of mTOR signaling in nasopharyngeal carcinoma cells |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2015 |
| Project Title: | Establishment of a shared live cell imaging platform for super-resolution microscopy |
| Investigator(s): | Tsao GSW, Bruzzone R, Chang RCC, Cheung MCH, Ching YP, Fu C, Huen MSY, Jin D, Yang D, Yu C, Yuen KWY |
| Department: | Anatomy |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Major Equipment Project |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Researcher : Tsao GSW |
| Project Title: | Cancer |
| Investigator(s): | Tsao GSW, Poon RTP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 11/2008 |
| Project Title: | The role of TGF-beta in EBV infection and pathogenesis of nasopharyngeal carcinoma |
| Investigator(s): | Tsao GSW, Lan HY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2009 |
| Project Title: | The role of cyclin D1 in the persistence of Epstein-Barr virus (EBV) infection in premalignant nasopharyngeal epithelial cells. |
| Investigator(s): | Tsao GSW, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2011 |
| Completion Date: | 09/2014 |
| Project Title: | The role of ATM signaling in the lytic replication of Epstein-Barr virus in infected nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW, Chiang AKS, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Project Title: | Functional interaction of EBV-encoded BZLF1 with the DNA damage repair proteins |
| Investigator(s): | Tsao GSW, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2013 |
| Completion Date: | 04/2015 |
| Project Title: | Systematic Development of Molecular Targets for Nasopharyngeal Carcinoma |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 01/2014 |
| Project Title: | Dynamics of EBV episome maintenance in infected nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW, Chen H, Deng W |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Advances in Live Cell and Intravital Imaging in Biomedicine |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Croucher Foundation - Conference / Seminars |
| Start Date: | 03/2014 |
| Project Title: | Live cell imaging of invasion by EBV-infected nasopharyngeal epithelial cells. |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2014 |
| Project Title: | Regulation of invadopodia formation by the EBV-encoded LMP1 in nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Annual meeting 2015 of American Association for Cancer Research; The role of NF-kB activation in the immortalization of nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2015 |
| Completion Date: | 04/2015 |
| Project Title: | Delineating the signal pathways of LMP1 in the activation of mTOR signaling in nasopharyngeal carcinoma cells |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2015 |
| Project Title: | Establishment of a shared live cell imaging platform for super-resolution microscopy |
| Investigator(s): | Tsao GSW, Bruzzone R, Chang RCC, Cheung MCH, Ching YP, Fu C, Huen MSY, Jin D, Yang D, Yu C, Yuen KWY |
| Department: | Anatomy |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Major Equipment Project |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Chan K.C., Ting C.M., Chan P.S., Lo M.C., Lo K.W., Smyth T., Lee A.W.M., Ng W.T., Tsao G.S.W., Wong R.N., Lung M.L. and Mak N.K., Study of a novel Hsp90 inhibitor AT13387 as potential therapeutic agent in EBV-associated nasopharyngeal carcinoma, 16th International Symposium on EBV and Associated Diseases. Brisbane, Australia. 2014. |
| Chan K.C., Chan L.S., Ip J.C.Y., Lo C., Yip T.T.C., Ngan R.K.C., Wong R.N.S., Lo K.W., Ng W.T., Lee A.W.M., Tsao G.S.W., Kahn M., Mak N.K. and Lung M.L., Therapeutic targeting of CBP/β-catenin signaling reduces cancer stem-like population and synergistically suppresses growth of EBV-positive nasopharyngeal carcinoma cells with cisplatin, Scientific Reports. 2015, 5: 9979. |
| Chan Y.K., Zhang H.M., Liu P., Tsao G.S.W., Lung M.L., Mak N.K., Wong R.N. and Yue P.Y., Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins, International Journal of Cancer. 2015, n/a-n/a. |
| Cheung A., XU W., Li B., Tsao G.S.W. and Chan K.W., Role of Id1-IGF2-VEGF-VEGFR relay in esophageal tumorigenesis, 23rd Biennial Congress of the European Association for Cancer Research, July 5-8, 2014 Munich, Germany.. 2014, 50 suppl. 5: S35 No. 161. |
| Cheung A., HAN L., Li B., Tsao G.S.W., Law S.Y.K., Chan K.W. and Lam A.K.Y., Role of miR-338-5p as a novel modulator of chemoresistannce in esophageal cancer, EACR AACR SIC Conference, June 20-23, Florence Italy. 2015. |
| Deng W., ZHOU Y., Tiwari A.F.Y., Su H., Yang J., ZHU D., LAU M.Y., Hau P.M., Yip Y.L., Cheung A., Guan X. and Tsao G.S.W., p21/Cyclin E pathway modulates anticlastogenic function of Bmi-1 in cancer cells., International Journal of Cancer. 2015, 136: 1361-1370. |
| HAN L., Li B., Tsao G.S.W. and Cheung A., Roles of miR-338-5p in downregulating Id1 and inhibiting chemoresistance, 21st Hong Kong International Cancer Congress, November 21, 2014, Hong Kong.. 2014, No. A16. |
| Hau P.M., Deng W., Jia L.J., YANG J., Tsurumi T., Chiang A.K.S., Huen M.S.Y. and Tsao G.S.W., Role of ATM in the formation of the replication compartment during lytic replication of Epstein-Barr virus in nasopharyngeal epithelial cells, Journal of Virology. 2015, 89: 652-668. |
| Hui K.F., CHOI C.K., YEUNG P.L., MIDDELDORP J.M., Tsao G.S.W. and Chiang A.K.S., Inhibition of class I histone deacetylases (HDACs) by HDAC inhibitiors leads to the induction of Epstein-Barr virus (EBV) lytic cycle in EBV-positive epithelial malignancies, 16th International Symposium on EBV and Associated Diseases. 2014. |
| Ip K.M., Yung S.S.Y., Chan D.T.M., Tsao G.S.W. and Wong A.S.T., p70 S6 kinase drives ovarian cancer metastasis through multicellular spheroid-peritoneum interaction and P-cadherin/beta1 integrin signaling activation, Oncotarget. 2014, 5: 9133-9149. |
| LUO Y., Sit A.K., Sihoe D.L.A., Suen W.S., Au T.W.K., Tang X., Ma E.S.K., Chan W.K., Wistuba I.I., Minna J.D., Tsao G.S.W. and Lam C.L.D., Aberrant large tumor suppressor 2 (LATS2) gene expression correlates with EGFR mutation and survival in lung adenocarcinomas, Lung Cancer. Elsevier, 2014, 85 (2): 282 - 292. |
| Lam C.L.D., Luo S.Y., Deng W., Kwan S.H., Rodriguez-Canales J., Cheung A., Cheng G.H.W., Lin C.H., Wistuba I.I., Sham P.C., Wan T.S.K. and Tsao G.S.W., Oncogenic mutation profiling in new lung cancer and mesothelioma cell lines, OncoTargets and Therapy. 2015, 8: 195-209. |
| Li B., XU W., Guan X., Law S.Y.K., Tsao G.S.W. and Cheung A., Suppression of esophageal tumor growth and chemoresistance by directly targeting the PI3K/AKT pathway, 2014 World Cancer Congress,December 3-6, Melbourne, Australia.. 2014, Abstract No. 1196. |
| Li B., Li J., Xu W., Guan X., Qin Y.R., Zhang L., Law S.Y.K., Tsao G.S.W. and Cheung A., Suppression of esophageal tumor growth and chemoresistance by directly targeting the PI3K/AKT pathway, Oncotarget. 2014, 5(22): 11576-11587. |
| Li B., HAN L., Chan K.W., Law S., Lam A.K.Y., Tsao G.S.W. and Cheung A., Suppressive effects of Id1-targeting microRNAs in metastasis of esophageal cancer, 21st Hong Kong International Cancer Congress, November 21, 2014, Hong Kong.. 2014, No. A17. |
| Lin W.T., Yip Y.L., Lo K.W., Deng W. and Tsao G.S.W., Establishment of new nasopharyngeal carcinoma xenografts in immunodeficient mice, Hong Kong International Cancer Congress. 2014. |
| Tiwari A.F.Y., Cheung S.T., Chan C.L.W., Ho R.T.H., Tsao G.S.W., Deng W., Hong W.L., Fong D.Y.T., Yuk Fung H...Y...K... and Ma J...L...C..., A Randomized, Wait-list Controlled Trial of a Qigong Intervention Program on Telomerase Activity and Psychological Stress in Abused Chinese Women, 7th International Congress on Innovations in Nursing, Perth, Australia, 20-21November, 2014. |
| Tiwari A.F.Y., Chan C.L.W., Ho R.T.H., Tsao G.S.W., Deng W., Hong W.L., Fong D.Y.T., Fung H.Y.K.Y., Cheung S.T. and Ma J.L.C., Effect of a qigong intervention program on telomerase activity and psychological stress in abused Chinese women: a randomized, wait-list controlled trial, BMC Complementary and Alternative Medicine. 2014, 14: 300. |
| Tsang C.M., Cheung K.C., Cheung Y.C., Man K., Lui W.Y.V., Feng Y. and Tsao G.S.W., Berberine suppresses Id-1 expression and inhibits the growth and development of lung metastases in hepatocellular carcinoma, Biochimica et Biophysica Acta. 2014, Epub on 2014-12-08. |
| Tsang C.M., Deng W., Yip Y.L., Zeng M.S., Lo K.W. and Tsao G.S.W., Epstein-Barr virus infection and persistence in nasopharyngeal epithelial cells, Chinese Journal of Cancer. 2014, 33: 549-555. |
| Tsao G.S.W., Tsang C.M., Yip Y.L., Lung M.L. and Lo K.W., Biology of EBV infection in nasopharyngeal epithelial cells, 16th International Symposium on EBV and Associated Diseases. Brisbane, Australia. 2014. |
| Tsao G.S.W., Ebv Infection Of Human Nasopharyngeal Epithelial Cells. , International Association For Research On Epstein-barr Virus And associated Disease. Brisbane, Sydney, 2014 July. 2014. |
| XIANG Z., Liu Y., Zheng J., Liu M., LU A., GAO Y., Hu H., Lam K.T., Chan G.C.F., Yang Y., Chen H., Tsao G.S.W., Bonneville M M., Lau Y.L. and Tu W., Targeted Activation of Human Vγ9Vδ2-T Cells Controls Epstein-Barr Virus-Induced B Cell Lymphoproliferative Disease, Cancer Cell. 2014. |
| XU W., Li B., Li Y.Y., Tsao G.S.W. and Cheung A., Blocking the PI3K/AKT pathway can impair metastasis of esophageal cancer, 2014 World Cancer Congress, December 3-6, 2014, Melbourne, Australia.. 2014, Abstract No. 942. |
| XU W., Li B., Tsao G.S.W., Chan K.W. and Cheung A., IGI-induced IGF2 promotes esophageal cancer progression through instigation of stromal fibroblasts and bone marrow-drived vancular progenitor cells, 21st Hong Kong International Cancer Congress, November 21, 2014 Hong Kong. 2014, No. A11. |
| XU W., Li B., Lam A.K.Y., Tsao G.S.W., Law S.Y.K., Chan K.W., Yuan Q. and Cheung A., Targeting VEGFR-1 and VEGFR2-expressing non-tumor cells is essential for esophageal cancer therapy, Oncotarget. 2014, 6(3): 1790-1805. |
| Yang J., Deng W., Hau P.M., LIU J., LAU M.Y., Cheung A., Huen M.S.Y. and Tsao G.S.W., Epstein-Barr virus BZLF1 protein impairs accumulation of host DNA damage proteins at damage sites in response to DNA damage, Laboratory Investigation. 2015. |
| Yuen K.S., Chan C.P., Wong N.H.M., HO C.H., HO T.H., Lei T., Deng W., Tsao G.S.W., Chen H., Kok K.H. and Jin D., CRISPR/Cas9-mediated genome editing of Epstein-Barr virus in human cells, Journal of General Virology. 2015, 96: 626-636. |
| Yuk H.Y.K., Ma J.L.C., Tiwari A.F.Y., Chan C.L.W., Ho R.T.H., Tsao G.S.W., Deng W., Hong W.L. and Fong D.Y.T., A randomized, wait-list controlled trial of a Qigong Intervention Program on Telomerase Activity and Psychological Stress in abused Chinese women, 7th International Congress on Innovations in Nursing. 2014. |
| Zhang G., Zong J., VERHOEVEN R.J.A., TONG S., Ji M., Cheng W., Lung M.L., Tsao G.S.W., Pan J. and Chen H., Characterization of extracellular secreted Epstein-Barr virus BART microRNAs as serological markers for nasopharyngeal carcinoma diagnosis and treatment, 16th International Symposium On Epstein-barr Virus And Associated Diseases, July 16-19, 2014, Brisbane, Australia. 2014. |
| Zhang G., Zong J., Lin S.H.A.O.J.U.N., VERHOEVEN R.J.A., TONG S., Chen Y., Ji M., Cheng W., Tsao G.S.W. and Lung M.L., Circulating Epstein-Barr virus microRNAs miR-BART7 and miR-BART13 as biomarkers for nasopharyngeal carcinoma diagnosis and treatment, International Journal of Cancer. 2014, n/a-n/a. |
| Researcher : Tse EYT |
| Project Title: | Characterization of NIMA (never in mitosis gene a)-related kinase 2 (Nek2) in Hepatocellular Carcinoma (HCC) |
| Investigator(s): | Tse EYT, Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2013 |
| Completion Date: | 11/2014 |
| List of Research Outputs |
| Tse E.Y.T. and Ching Y.P., The role of p21-activated kinases in hepatocellular carcinoma metastasis, Journal of Molecular Signaling . BioMed Central, 2014, 9. |
| Researcher : WU Y |
| List of Research Outputs |
| WU Y., The effects of Chinese medical terms on patient comprehension of information in a simulated clinical consultation, 2015, 184 pages. |
| Researcher : Wang K |
| List of Research Outputs |
| Wang K., Xiao J., PENG B., Xing F., So K.F., Tipoe G.L. and Lin B., Retinal structure and function preservation by polysaccharides of wolfberry in a mouse model of retinal degeneration, Scientific Reports. 2014, 4:7601; DOI:10.1038/srep07601. |
| Researcher : Wang X |
| Project Title: | The role fo MAD2 in overcoming cisplatin resistance in testicular germ cell tumors |
| Investigator(s): | Wang X, Jin D |
| Department: | Anatomy |
| Source(s) of Funding: | Lance Armstrong Foundation - General Award |
| Start Date: | 10/2003 |
| Project Title: | Significance of MAD2 expression to chromosomal instability in prostate cancer |
| Investigator(s): | Wang X |
| Department: | Anatomy |
| Source(s) of Funding: | Association for International Cancer Research - General Award |
| Start Date: | 04/2004 |
| Project Title: | Molecular mechanisms involved in the suppressive effects of garlic derivatives on cell growth and motility in prostate cancer cells |
| Investigator(s): | Wang X |
| Department: | Anatomy |
| Source(s) of Funding: | American Institute for Cancer Research (AICR) - General Award |
| Start Date: | 08/2005 |
| Researcher : Wang X |
| Project Title: | Angio-(1-7) and ACE2 during normal and hypertensive pregnancy |
| Investigator(s): | Wang X, Ellis-Behnke RG |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2008 |
| Researcher : Wong WM |
| List of Research Outputs |
| Lu Y., Dong S., Hao B., Li C., Zhu K., Guo W., Wang Q., Cheung K.H., Wong W.M. and Wu W., Vacuolin-1 potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A, Autophagy. 2014, 10: 1895-1905. |
| Researcher : Wong YC |
| Project Title: | Induction of breast carcinogenesis by a combination of androgens and oestrogens |
| Investigator(s): | Wong YC, Xie B |
| Department: | Anatomy |
| Source(s) of Funding: | Other Funding Scheme |
| Start Date: | 07/1997 |
| Project Title: | The Beijing, Hong Kong and UK Collaborative Study on the Molecular Genetic Basis of Differential Susceptibility of Prostate Cancer Between Chinese and Caucasian |
| Investigator(s): | Wong YC, Wang X, Ho KMT |
| Department: | Anatomy |
| Source(s) of Funding: | The University of Hong Kong Foundation Seed Grant |
| Start Date: | 07/2003 |
| Researcher : Wu W |
| Project Title: | Effects of chondroitinase ABC and lithium chloride on neuronal survival and regeneration after spinal cord injury |
| Investigator(s): | Wu W, Yick LW, So KF |
| Department: | Anatomy |
| Source(s) of Funding: | Matching Fund for National Key Basic Research Development Scheme (973 Projects) |
| Start Date: | 11/2003 |
| Project Title: | Research Output Prize |
| Investigator(s): | Wu W, Su H, Wong WM, So KF, Wu EX |
| Department: | Anatomy |
| Source(s) of Funding: | Research Output Prize (in Faculty) |
| Start Date: | 10/2008 |
| Project Title: | Fabrication of a bioactive nanofibrous conduit for functional recovery of spinal cord injury |
| Investigator(s): | Wu W |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2014 |
| Project Title: | Bridge the gap in nerve tissue injury to promote axonal regeneration with fabrication of a bioactive nanofibrous conduit |
| Investigator(s): | Wu W |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 07/2014 |
| Project Title: | Spinal cord injury in developing and adult rats: different outcome and potential mechanisms. |
| Investigator(s): | Wu W |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2015 |
| Project Title: | Repairing neural damage after spinal cord injury with self-assembling peptide nanofiber scaffold (SAPNS) |
| Investigator(s): | Wu W |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| List of Research Outputs |
| Ding Y., Qu Y., Feng J., Wang M., Han Q., So K.F., Wu W. and Zhou L., Functional motor recovery from motoneuron axotomy is compromised in mice with defective corticospinal projections, PLOS ONE. 2014, 9(7): e101918. |
| Gao M., Guo J., Leung G.K.K. and Wu W., Use of self-assembly nanofibre biomaterials for neural repair after injury, In: Maguire R. (ed.), Advances in Nanofibers. Croatia, InTech, 2015. |
| Han Q., Cao C., Ding Y., So K.F., Wu W., Qu Y. and Zhou L., Plasticity of motor network and function in the absence of corticospinal projection, Experimental Neurology. 2015, 267: 194-208. |
| Lu Y., Dong S., Hao B., Li C., Zhu K., Guo W., Wang Q., Cheung K.H., Wong W.M. and Wu W., Vacuolin-1 potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A, Autophagy. 2014, 10: 1895-1905. |
| Sang L.Y.H., Yang X.Y., Su H.X., Leung G.K.K., Wu W. and Cheung R.T.F., Local delivery of neural progenitor cells and nanomaterial improves functional outcome in a rat model of intracerebral hemorrhage, The European Stroke Organization Conference 2015, Glasgow, U.K., 17-19 April 2015. |
| Sang L.Y.H., Yang X., Su H.X., Leung G.K.K., Wu W. and Cheung R.T.F., Replacement of hematoma with neural progenitor cells embedded in a nanomaterial in a rat model of intracerebral hemorrhage, The 21st Annual Scientific Meeting of the Hong Kong Neurosurgical Society, Hong Kong, 5-6 December 2014. |
| Xu F.F., Wang Y., Sun S., Ho S.W.A., Lee D., KIANG M.Y., ZHANG X., Lui W.M., Liu B.Y., Wu W. and Leung G.K.K., Comparison between self-assembling peptide nanofiber scaffold (SAPNS) and fibrin sealant in neurosurgical hemostasis, Clinical Translational Science. 2015. |
| Researcher : XU W |
| List of Research Outputs |
| Cheung A., XU W., Li B., Tsao G.S.W. and Chan K.W., Role of Id1-IGF2-VEGF-VEGFR relay in esophageal tumorigenesis, 23rd Biennial Congress of the European Association for Cancer Research, July 5-8, 2014 Munich, Germany.. 2014, 50 suppl. 5: S35 No. 161. |
| Li B., XU W., Guan X., Law S.Y.K., Tsao G.S.W. and Cheung A., Suppression of esophageal tumor growth and chemoresistance by directly targeting the PI3K/AKT pathway, 2014 World Cancer Congress,December 3-6, Melbourne, Australia.. 2014, Abstract No. 1196. |
| Li B., Li J., Xu W., Guan X., Qin Y.R., Zhang L., Law S.Y.K., Tsao G.S.W. and Cheung A., Suppression of esophageal tumor growth and chemoresistance by directly targeting the PI3K/AKT pathway, Oncotarget. 2014, 5(22): 11576-11587. |
| XU W., Li B., Li Y.Y., Tsao G.S.W. and Cheung A., Blocking the PI3K/AKT pathway can impair metastasis of esophageal cancer, 2014 World Cancer Congress, December 3-6, 2014, Melbourne, Australia.. 2014, Abstract No. 942. |
| XU W., Li B., Tsao G.S.W., Chan K.W. and Cheung A., IGI-induced IGF2 promotes esophageal cancer progression through instigation of stromal fibroblasts and bone marrow-drived vancular progenitor cells, 21st Hong Kong International Cancer Congress, November 21, 2014 Hong Kong. 2014, No. A11. |
| XU W., Li B., Lam A.K.Y., Tsao G.S.W., Law S.Y.K., Chan K.W., Yuan Q. and Cheung A., Targeting VEGFR-1 and VEGFR2-expressing non-tumor cells is essential for esophageal cancer therapy, Oncotarget. 2014, 6(3): 1790-1805. |
| XU W., Li B. and Cheung A., The potential of targeted antiangiogenesis therapies in the treatment of esophageal cancer, Gastrointestinal Cancer: Targets and Therapy. 2015, 5: 79-88. |
| Researcher : Xiao J |
| List of Research Outputs |
| Bie M., Lv Y., Ren C., Xing F., Cui Q., Xiao J. and So K.F., Lycium barbarum Polysaccharide Improves Bipolar Pulse Current-Induced Microglia Cell Injury Through Modulating Autophagy, Cell Transplantation. 2015, 24: 419-428. |
| So K.F., Ren C., Xiao J., Bie M., Lv Y., Xing F.Y. and C Q., Lycium barbarum Polysaccharide Improves Bipolar Pulse Current-Induced Microglia Cell Injury Through Modulating Autophagy, Cell Transplantation. USA, Cognizant Comm. Corp., 2015, 24: 419-428. |
| Wang K., Xiao J., PENG B., Xing F., So K.F., Tipoe G.L. and Lin B., Retinal structure and function preservation by polysaccharides of wolfberry in a mouse model of retinal degeneration, Scientific Reports. 2014, 4:7601; DOI:10.1038/srep07601. |
| Xiao J., Liong E.C., Huang H., Tse W.O., Lau K.S., Pan J., Nanji A.A., Fung M.L., Xing F. and Tipoe G.L., Cycloxygenase-1 serves a vital hepato-protective function in chemically induced acute liver injury, Toxicological Sciences. 2015, 143(2): 430-440. |
| Researcher : Xu W |
| List of Research Outputs |
| Cheung A., XU W., Li B., Tsao G.S.W. and Chan K.W., Role of Id1-IGF2-VEGF-VEGFR relay in esophageal tumorigenesis, 23rd Biennial Congress of the European Association for Cancer Research, July 5-8, 2014 Munich, Germany.. 2014, 50 suppl. 5: S35 No. 161. |
| Li B., XU W., Guan X., Law S.Y.K., Tsao G.S.W. and Cheung A., Suppression of esophageal tumor growth and chemoresistance by directly targeting the PI3K/AKT pathway, 2014 World Cancer Congress,December 3-6, Melbourne, Australia.. 2014, Abstract No. 1196. |
| Li B., Li J., Xu W., Guan X., Qin Y.R., Zhang L., Law S.Y.K., Tsao G.S.W. and Cheung A., Suppression of esophageal tumor growth and chemoresistance by directly targeting the PI3K/AKT pathway, Oncotarget. 2014, 5(22): 11576-11587. |
| XU W., Li B., Li Y.Y., Tsao G.S.W. and Cheung A., Blocking the PI3K/AKT pathway can impair metastasis of esophageal cancer, 2014 World Cancer Congress, December 3-6, 2014, Melbourne, Australia.. 2014, Abstract No. 942. |
| XU W., Li B., Tsao G.S.W., Chan K.W. and Cheung A., IGI-induced IGF2 promotes esophageal cancer progression through instigation of stromal fibroblasts and bone marrow-drived vancular progenitor cells, 21st Hong Kong International Cancer Congress, November 21, 2014 Hong Kong. 2014, No. A11. |
| XU W., Li B., Lam A.K.Y., Tsao G.S.W., Law S.Y.K., Chan K.W., Yuan Q. and Cheung A., Targeting VEGFR-1 and VEGFR2-expressing non-tumor cells is essential for esophageal cancer therapy, Oncotarget. 2014, 6(3): 1790-1805. |
| XU W., Li B. and Cheung A., The potential of targeted antiangiogenesis therapies in the treatment of esophageal cancer, Gastrointestinal Cancer: Targets and Therapy. 2015, 5: 79-88. |
| Researcher : YANG J |
| List of Research Outputs |
| Chan L.K. and Yang J., The application of one-minute preceptor technique in the gross-anatomy laboratory, International Anatomical Sciences and Cell Biology Conference, 10-13 December 2014, Taiwan.. 2014. |
| Deng W., ZHOU Y., Tiwari A.F.Y., Su H., Yang J., ZHU D., LAU M.Y., Hau P.M., Yip Y.L., Cheung A., Guan X. and Tsao G.S.W., p21/Cyclin E pathway modulates anticlastogenic function of Bmi-1 in cancer cells., International Journal of Cancer. 2015, 136: 1361-1370. |
| Hau P.M., Deng W., Jia L.J., YANG J., Tsurumi T., Chiang A.K.S., Huen M.S.Y. and Tsao G.S.W., Role of ATM in the formation of the replication compartment during lytic replication of Epstein-Barr virus in nasopharyngeal epithelial cells, Journal of Virology. 2015, 89: 652-668. |
| Liang Y., Yang J., Yuan T.F. and So K.F., Uptake of Retrograde Tracers by Intact Optic Nerve Axons: A New Way to Label Retinal Ganglion Cells, PLOS ONE. 2015, 10: e0128718. |
| Yang J., Deng W., Hau P.M., LIU J., LAU M.Y., Cheung A., Huen M.S.Y. and Tsao G.S.W., Epstein-Barr virus BZLF1 protein impairs accumulation of host DNA damage proteins at damage sites in response to DNA damage, Laboratory Investigation. 2015. |
| Researcher : YE L |
| List of Research Outputs |
| Ho J.W.Y., Wong N.S., YE L., Chan L.K. and Sham M.H., ePoster Award (Second runner up), Title: Virtually there: a journey to the HKU Medicine Island for teachnig and learning, HKU Li Ka Shing Faculty of Medicine Frontiers Series – East-West Alliance Global Symposia. 2014. |
| Researcher : YOU R |
| List of Research Outputs |
| YOU R., CHENG S.Y., Hung C.H.L., Ho Y.S. and Chang R.C.C., Investigating the effects of FITC-tagged SiO2-NPs on tau and synaptic protein in primary culture of cortical neurons, The 10th International Symposium on Healthy Aging. 2015. |
| Researcher : Yang J |
| Project Title: | Investigation of physiology and possible neuroprotective effect of the retinal microglia under normal and glaucoma conditions |
| Investigator(s): | Yang J, So KF, Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2008 |
| List of Research Outputs |
| Chan L.K. and Yang J., The application of one-minute preceptor technique in the gross-anatomy laboratory, International Anatomical Sciences and Cell Biology Conference, 10-13 December 2014, Taiwan.. 2014. |
| Deng W., ZHOU Y., Tiwari A.F.Y., Su H., Yang J., ZHU D., LAU M.Y., Hau P.M., Yip Y.L., Cheung A., Guan X. and Tsao G.S.W., p21/Cyclin E pathway modulates anticlastogenic function of Bmi-1 in cancer cells., International Journal of Cancer. 2015, 136: 1361-1370. |
| Hau P.M., Deng W., Jia L.J., YANG J., Tsurumi T., Chiang A.K.S., Huen M.S.Y. and Tsao G.S.W., Role of ATM in the formation of the replication compartment during lytic replication of Epstein-Barr virus in nasopharyngeal epithelial cells, Journal of Virology. 2015, 89: 652-668. |
| Liang Y., Yang J., Yuan T.F. and So K.F., Uptake of Retrograde Tracers by Intact Optic Nerve Axons: A New Way to Label Retinal Ganglion Cells, PLOS ONE. 2015, 10: e0128718. |
| Yang J., Deng W., Hau P.M., LIU J., LAU M.Y., Cheung A., Huen M.S.Y. and Tsao G.S.W., Epstein-Barr virus BZLF1 protein impairs accumulation of host DNA damage proteins at damage sites in response to DNA damage, Laboratory Investigation. 2015. |
| Researcher : Yang J |
| List of Research Outputs |
| Chan L.K. and Yang J., The application of one-minute preceptor technique in the gross-anatomy laboratory, International Anatomical Sciences and Cell Biology Conference, 10-13 December 2014, Taiwan.. 2014. |
| Deng W., ZHOU Y., Tiwari A.F.Y., Su H., Yang J., ZHU D., LAU M.Y., Hau P.M., Yip Y.L., Cheung A., Guan X. and Tsao G.S.W., p21/Cyclin E pathway modulates anticlastogenic function of Bmi-1 in cancer cells., International Journal of Cancer. 2015, 136: 1361-1370. |
| Hau P.M., Deng W., Jia L.J., YANG J., Tsurumi T., Chiang A.K.S., Huen M.S.Y. and Tsao G.S.W., Role of ATM in the formation of the replication compartment during lytic replication of Epstein-Barr virus in nasopharyngeal epithelial cells, Journal of Virology. 2015, 89: 652-668. |
| Liang Y., Yang J., Yuan T.F. and So K.F., Uptake of Retrograde Tracers by Intact Optic Nerve Axons: A New Way to Label Retinal Ganglion Cells, PLOS ONE. 2015, 10: e0128718. |
| Yang J., Deng W., Hau P.M., LIU J., LAU M.Y., Cheung A., Huen M.S.Y. and Tsao G.S.W., Epstein-Barr virus BZLF1 protein impairs accumulation of host DNA damage proteins at damage sites in response to DNA damage, Laboratory Investigation. 2015. |
| Researcher : Yang X |
| List of Research Outputs |
| Sang L.Y.H., Yang X., Su H.X., Leung G.K.K., Wu W. and Cheung R.T.F., Replacement of hematoma with neural progenitor cells embedded in a nanomaterial in a rat model of intracerebral hemorrhage, The 21st Annual Scientific Meeting of the Hong Kong Neurosurgical Society, Hong Kong, 5-6 December 2014. |
| Researcher : Yau SY |
| List of Research Outputs |
| Yau S.Y., Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin, PNAS. 2014, Nov 4 (111), 44: 15810-15815. |
| Yau S.Y., LI A., Hoo R.L.C., Ching Y.P., Christie B... .R..., Lee T.M.C., Xu A. and So K.F., Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin, Proceedings of the National Academy of Sciences. United States of America, Proceedings of the National Academy of Sciences of the US, 2014, 111: 15810-15815. |
| Researcher : Yeung PKK |
| Project Title: | The Effectiveness of Vasopressin V1 receptor antagonist , SR49059, and V2 Receptor Anatongist, OPC-31260, on Cerebral Edema Formation in Endothelin-1-Overexpressed Mice |
| Investigator(s): | Yeung PKK, Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2008 |
| List of Research Outputs |
| Guo Y., Chung S.K., Siu D.C.W., Kwan S.C., Ho W.L., Yeung P.K.K. and Chan K.H., Endothelin-1 overexpression exacerbate experimental allergic encephalomyelitis, Journal of Neuroimmunology. 2014. |
| Researcher : Yip HKF |
| Project Title: | In vivo gene transfer of the catalytic subunit of telomerase protects retinal ganglion cells against axotomy-induced cell death |
| Investigator(s): | Yip HKF, Tsao GSW, Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2005 |
| Project Title: | Telomerase immortalization of retinal ganglion cells derived from the embryonic mouse retinal progenitor cells |
| Investigator(s): | Yip HKF, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2009 |
| Project Title: | Combined treatment of lithium and noggin inhibits astroglios after spinal cord injury by deactivation of GSK-3β/STAT3 are BMP/Smad pathways in the endogenous adult neural stem cells |
| Investigator(s): | Yip HKF, Shum DKY |
| Department: | Anatomy |
| Source(s) of Funding: | Spinal Cord Injury Research Grant |
| Start Date: | 05/2010 |
| Project Title: | Inhibition of GSK3β promotes generation of functional oligodendrocytes from progenitor cells of adult injured spinal cord |
| Investigator(s): | Yip HKF |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2014 |
| Completion Date: | 05/2015 |
| Project Title: | Lithium treatment increases the expression of brain-derived neurotrophic factor in the injured adult spinal cord. |
| Investigator(s): | Yip HKF |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2015 |
| List of Research Outputs |
| PAN Y., DAI Y., Cheung M.P.L. and Yip H.K.F., The Inhibition Of GSK3β Promotes Oligodendroglial Progenitor Cell Differentiation In Spinal Cord Injury, Federation Of European Neuroscience Societies Annual Meeting. 2014. |
| PAN Y., DAI Y. and Yip H.K.F., The Role of GSK3β Pathway in Oligodendroglial Progenitor Cell (OPC) Differentiation and Remyelination after Spinal Cord Injury (SCI), 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, HKU. 2014. |
| Researcher : Yip VSP |
| List of Research Outputs |
| Botelho M.G., Lam O.L.T., Watt R.M., Yip V.S.P., Shum D.K.Y. and Lung M.A.K.Y., Peer generated MCQs to assess and support for learning in a Problem Based Learning Programme, International Conference: Assessment for Learning in Higher Education 2015. . |
| Researcher : Yip YL |
| Project Title: | Establishment and characterization of representative nasopharyngeal carcinoma cell lines |
| Investigator(s): | Yip YL, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2014 |
| List of Research Outputs |
| Deng W., ZHOU Y., Tiwari A.F.Y., Su H., Yang J., ZHU D., LAU M.Y., Hau P.M., Yip Y.L., Cheung A., Guan X. and Tsao G.S.W., p21/Cyclin E pathway modulates anticlastogenic function of Bmi-1 in cancer cells., International Journal of Cancer. 2015, 136: 1361-1370. |
| Lin W.T., Yip Y.L., Lo K.W., Deng W. and Tsao G.S.W., Establishment of new nasopharyngeal carcinoma xenografts in immunodeficient mice, Hong Kong International Cancer Congress. 2014. |
| Tsang C.M., Deng W., Yip Y.L., Zeng M.S., Lo K.W. and Tsao G.S.W., Epstein-Barr virus infection and persistence in nasopharyngeal epithelial cells, Chinese Journal of Cancer. 2014, 33: 549-555. |
| Tsao G.S.W., Tsang C.M., Yip Y.L., Lung M.L. and Lo K.W., Biology of EBV infection in nasopharyngeal epithelial cells, 16th International Symposium on EBV and Associated Diseases. Brisbane, Australia. 2014. |
| Yip Y.L., Establishment of NPC xenografts and cell lines, Croucher Foundation Advanced Study Institute on Advances in Nasopharyngeal Carcinoma Studies. 2014. |
| Researcher : Yu C |
| Project Title: | Down-regulation of integrin-beta3 by clathrin-mediated endocytosis |
| Investigator(s): | Yu C |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 11/2014 |
| Project Title: | 2014 The American Society for Cell Biology Annual Meeting; Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force |
| Investigator(s): | Yu C |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 12/2014 |
| Completion Date: | 12/2014 |
| List of Research Outputs |
| Iversen L., Tu H., Lin W., Christensen S., Abel S., Iwig J., Wu H., Gureasko J., Rhodes C., Petit R., Hansen S., Thill P., Yu C., Stamou D., Chakraborty A., Kuriyan J. and Groves J., Ras activation by SOS: Allosteric regulation by altered fluctuation dynamics, Science. 2014, 345: 50-54. |
| Wu J.T., Yu C., Li S., Zou B., Liu Y., Zhu X., Guo Y., Xu H., Zhang W. and Zhang L., Parallel Near-Field Photolithography with Metal-Coated Elastomeric Masks, Langmuir. 2015, 31: 1210-1217. |
| Yu C., PI3K signaling at invadosomes, Seminar, Sun Yat-sen University Cancer Center, Guangzhou, P.R.C. . 2014. |
| Yu C., Spatial-temporal integrin activation and PI3K signaling at invadopodia : microenvironment modulates adhesion signaling , Seminar, College of Life Science and Technology, Jinan University, R.R.C.. 2014. |
| Researcher : Yuan Q |
| List of Research Outputs |
| XU W., Li B., Lam A.K.Y., Tsao G.S.W., Law S.Y.K., Chan K.W., Yuan Q. and Cheung A., Targeting VEGFR-1 and VEGFR2-expressing non-tumor cells is essential for esophageal cancer therapy, Oncotarget. 2014, 6(3): 1790-1805. |
| Researcher : ZHOU L |
| List of Research Outputs |
| ZHOU L., Role of exchange protein directly activated by cAMP in neurogenesis and serotonergic system: Implication in affective disorders, 2015, 205 pages. |
| Researcher : ZHOU Y |
| List of Research Outputs |
| Deng W., ZHOU Y., Tiwari A.F.Y., Su H., Yang J., ZHU D., LAU M.Y., Hau P.M., Yip Y.L., Cheung A., Guan X. and Tsao G.S.W., p21/Cyclin E pathway modulates anticlastogenic function of Bmi-1 in cancer cells., International Journal of Cancer. 2015, 136: 1361-1370. |
| Researcher : ZHU D |
| List of Research Outputs |
| Deng W., ZHOU Y., Tiwari A.F.Y., Su H., Yang J., ZHU D., LAU M.Y., Hau P.M., Yip Y.L., Cheung A., Guan X. and Tsao G.S.W., p21/Cyclin E pathway modulates anticlastogenic function of Bmi-1 in cancer cells., International Journal of Cancer. 2015, 136: 1361-1370. |