DEPT OF PHYSIOLOGY
| Researcher : Ballard HJ |
| Project Title: | Involvement of chloride channels in ATP release from skeletal muscle |
| Investigator(s): | Ballard HJ |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2012 |
| Completion Date: | 04/2014 |
| Project Title: | Involvement of connexin hemichannels in ATP release from skeletal muscle |
| Investigator(s): | Ballard HJ |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2013 |
| Project Title: | 2013 Congress of the International Union of Physiological Sciences; Involvement Of Connexin Hemichannels In Acidosis- And Exercise-Induced ATP Release From Skeletal Muscle |
| Investigator(s): | Ballard HJ |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2013 |
| Completion Date: | 07/2013 |
| Project Title: | ATP release from vascular endothelium and erythrocytes during skeletal muscle contraction |
| Investigator(s): | Ballard HJ |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| List of Research Outputs |
| Ballard H.J., ATP and adenosine in the regulation of skeletal muscle blood flow during exercise, Acta Physiologica Sinica. 2014, 66: 67-78. |
| Ballard H.J., LU L. and CAI W., Involvement of connexin hemichannels in acidosis- and exercise-induced ATP release from skeletal muscle., 37th International Union of Physiological Sciences. 2013, 531P. |
| LU L., Tu J., Cai W.S. and Ballard H.J., ATP release from rat skeletal muscle may involve chloride channels., 37th International Union of Physiological Sciences. 2013, 909P. |
| LU L., Tu J. and Ballard H.J., Connexin-hemichannels are involved in Acidosis-induced ATP Release From Skeletal Myocytes., Journal of the Hong Kong College of Cardiology. 2013, 21: 67. |
| Tu J., LU L. and Ballard H.J., Acidosis-induced ATP release from skeletal muscle involves activation of CFTR through the cAMP/PKA pathway. , 37th International Union of Physiological Sciences. 2013, 530P-531P. |
| Researcher : Bourreau JP |
| Project Title: | Role of cyclooxygenase in the ventricular effects of adrenomedullin: does prostacyclin contribute towards the cardiodepression in the late hypodynamic phase of septic shock? |
| Investigator(s): | Bourreau JP |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Project Title: | Endothelim-dependent hyperpolarization and relaxation of vascular smooth muscle: influence of the mode of excitation-coupling of vasoconstrictors |
| Investigator(s): | Bourreau JP |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 02/2005 |
| Project Title: | Switch in G-protein coupling. Role of intracellular cAMP |
| Investigator(s): | Bourreau JP |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2006 |
| Researcher : Bu L |
| Project Title: | Investigation of the relationship between ISL1+ and WT1+ heart progenitor cells in humans |
| Investigator(s): | Bu L, Li RA |
| Department: | Medicine |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2012 |
| Project Title: | Study of cardiomyopathy through genome editing in human pluripotent stem cells |
| Investigator(s): | Bu L, Li RA |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2013 |
| Completion Date: | 12/2014 |
| Researcher : CAI W |
| List of Research Outputs |
| Ballard H.J., LU L. and CAI W., Involvement of connexin hemichannels in acidosis- and exercise-induced ATP release from skeletal muscle., 37th International Union of Physiological Sciences. 2013, 531P. |
| Researcher : CHEN W |
| List of Research Outputs |
| CHEN W., Ma C.W., NG K.P., HU H., DE NOGUEIRA BOTELHO F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., Early postnatal disturbance of inhibitory transmission in the vestibular nucleus impacts on the thalamic spatial map and navigation behaviors, Abstracts of Physiology Symposium 2014 & Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 61. 2014. |
| CHEN W., DE NOGUEIRA BOTELHO F.P., Ma C.W., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of GABAergic synapses in the vestibular nucleus during a postnatal critical period impacts on the acquisition on spatial recognition, Proc. International Symposium on Physiomics p. 72.. 2013. |
| CHEN W., Ma C.W., DE NOGUEIRA BOTELHO F.P., SHI W., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of GABAergic synapses in the vestibular nucleus during a postnatal critical period impacts on the acquisition on spatial recognition, Proc.10th Biennial Conference of Chinese Society for Neuroscience S05. [Beijing. Sept. 20-22, 2013]. 2013. |
| CHEN W., Ma C.W., HU H., DE NOGUEIRA BOTELHO F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of the plasticity at GABAeric synapses in the vestibular nucleus during a critical period impacts on the thalamic spatial network and navigation behavior, Abstracts of 9th Int’l Symp. on Healthy Aging: Aging with Confidence51. 2014. |
| CHEN W., SHI W., Ma C.W., Lai C.H., Shum D.K.Y. and Chan Y.S., Plasticity of GABAergic synapses in the developing vestibular nucleus governs the expression of spatial navigation in mature rats, Proc. 37th Int’l Congress of International Union of Physiological Sciences PCB120. 2013. |
| Chan Y.S., DE NOGUEIRA BOTELHO F.P., CHEN W., SHI W., Ma C.W., Lai C.H. and Shum D.K.Y., Developmental assembly of neural correlates for head directions, Proc. International Symposium on Physiomics p. 8. [Taipei. Nov 1-2, 2013]. 2013. |
| Chan Y.S., CHEN W., Ma C.W., SHI W., DE NOGUEIRA BOTELHO F.P., Lai C.H. and Shum D.K.Y., GABAergic transmission in the critical period impacts on the thalamic spatial map and navigation behaviour, Society Neuroscience Abstract (USA), 164.10/MM2. 2013. |
| Chan Y.S., CHEN W., Ma C.W., SHI W., DE NOGUEIRA BOTELHO F.P., Lai C.H. and Shum D.K.Y., Plasticity of GABAergic synapses in the developing vestibular nucleus governs the expression of spatial navigation in mature rats, Soc. Neuroscience Abstract (USA) 164.10. 2013. |
| Researcher : Cai S |
| List of Research Outputs |
| Cai S., Chan Y.S. and Shum D.K.Y., Induced pluripotent stem cells and neurological disease models, Acta Physiologica Sinica. 2014, 66: 55-66. |
| Cai S., Chan Y.S. and Shum D.K.Y., Derivation of stable Schwann cells from human bone marrow stromal cells, Journal of Neurochemistry, 130 Suppl 1: 26. [11th Biennial Meeting of Asia-Pacific Society for Neurochemistry. Kaohsiung. August 23-26, 2014]. 2014. |
| Cai S., Chan Y.S. and Shum D.K.Y., Directed differentiation of human induced pluripotent stem cells to sensory neurons by combined small molecule inhibitors, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association 33. [HK. June 12-14, 2014] . 2014. |
| Cai S., Tsui Y.P., Shum D.K.Y. and Chan Y.S., Fate commitment of human bone marrow stromal cells to Schwann cells, Proc. 10th Biennial Conference of Chinese Society for Neuroscience P236. 2013. |
| Cai S., Tsui Y.P., Shum D.K.Y. and Chan Y.S., Mechanism underlying fate commitment of human bone marrow stromal cells to Schwann cells, Proc. International Symposium on Physiomics p.71. [Taipei. Nov. 1-2, 2013]. 2013. |
| Shum D.K.Y., Tsui Y.P., Cai S., TAI W.Y.E. and Chan Y.S., Oligodendrocyte precursors – in vitro derivation from bone marrow stromal cells and use in remyelination therapy, Proc. 10th Biennial Conference of Chinese Society for Neuroscience 15-01. [Beijing, China. Sept. 20-22, 2013]. ~ Proc. 10~th^~~ Biennial Conference of Chinese Society for Neuroscience/~~15-01, 2013. |
| Researcher : Chan YS |
| Project Title: | 30th Annual Conference of Society for Neuroscience Expression of N-Methyl-D-Aspartate Receptor Subunits and Induction of c-fos in Otolith Neurons in the Vestibular Nuclei of Postnatal Rats |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2000 |
| Project Title: | 31st Annual Meeting of Society for Neuroscience Expression of Neurotrophin Receptors in Vestibular Nuclei During the Postnatal Development of the Rat |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2001 |
| Project Title: | XXIV Annual Conference of Indian Academy of Neurosciences Development Refinement of Spatial Recognition Circuits |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 12/2006 |
| Project Title: | Role of the thalamus in integrating spatial information and guiding navigation |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2009 |
| Project Title: | Brain-derived neurotrophic factor regulates plasticity in the vestibular system |
| Investigator(s): | Chan YS, Shum DKY |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2010 |
| Completion Date: | 11/2013 |
| Project Title: | Outstanding Research Student Supervisor Award 2009-10 |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | Outstanding Research Student Supervisor Award |
| Start Date: | 12/2010 |
| Project Title: | Vestibular nuclear signals regulate the postnatal development of a thalamic network for spatial navigation |
| Investigator(s): | Chan YS, Shum DKY |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2011 |
| Project Title: | Long-term depression of inhibitory responses is critical to the maturation of the vestibular circuitry |
| Investigator(s): | Chan YS, Shum DKY |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2012 |
| Project Title: | IUPS 2013; Plasticity of GABAergic synapses in the developing vestibular nucleus governs the expression of spatial navigation in mature rats |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2013 |
| Completion Date: | 07/2013 |
| Project Title: | Serotonin-induced bidirectional modulation of activity-dependent synaptic plasticity tunes vestibular functions |
| Investigator(s): | Chan YS, Shum DKY |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2013 |
| List of Research Outputs |
| CHEN W., Ma C.W., NG K.P., HU H., DE NOGUEIRA BOTELHO F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., Early postnatal disturbance of inhibitory transmission in the vestibular nucleus impacts on the thalamic spatial map and navigation behaviors, Abstracts of Physiology Symposium 2014 & Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 61. 2014. |
| CHEN W., DE NOGUEIRA BOTELHO F.P., Ma C.W., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of GABAergic synapses in the vestibular nucleus during a postnatal critical period impacts on the acquisition on spatial recognition, Proc. International Symposium on Physiomics p. 72.. 2013. |
| CHEN W., Ma C.W., DE NOGUEIRA BOTELHO F.P., SHI W., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of GABAergic synapses in the vestibular nucleus during a postnatal critical period impacts on the acquisition on spatial recognition, Proc.10th Biennial Conference of Chinese Society for Neuroscience S05. [Beijing. Sept. 20-22, 2013]. 2013. |
| CHEN W., Ma C.W., HU H., DE NOGUEIRA BOTELHO F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of the plasticity at GABAeric synapses in the vestibular nucleus during a critical period impacts on the thalamic spatial network and navigation behavior, Abstracts of 9th Int’l Symp. on Healthy Aging: Aging with Confidence51. 2014. |
| CHEN W., SHI W., Ma C.W., Lai C.H., Shum D.K.Y. and Chan Y.S., Plasticity of GABAergic synapses in the developing vestibular nucleus governs the expression of spatial navigation in mature rats, Proc. 37th Int’l Congress of International Union of Physiological Sciences PCB120. 2013. |
| Cai S., Chan Y.S. and Shum D.K.Y., Induced pluripotent stem cells and neurological disease models, Acta Physiologica Sinica. 2014, 66: 55-66. |
| Cai S., Chan Y.S. and Shum D.K.Y., Derivation of stable Schwann cells from human bone marrow stromal cells, Journal of Neurochemistry, 130 Suppl 1: 26. [11th Biennial Meeting of Asia-Pacific Society for Neurochemistry. Kaohsiung. August 23-26, 2014]. 2014. |
| Cai S., Chan Y.S. and Shum D.K.Y., Directed differentiation of human induced pluripotent stem cells to sensory neurons by combined small molecule inhibitors, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association 33. [HK. June 12-14, 2014] . 2014. |
| Cai S., Tsui Y.P., Shum D.K.Y. and Chan Y.S., Fate commitment of human bone marrow stromal cells to Schwann cells, Proc. 10th Biennial Conference of Chinese Society for Neuroscience P236. 2013. |
| Cai S., Tsui Y.P., Shum D.K.Y. and Chan Y.S., Mechanism underlying fate commitment of human bone marrow stromal cells to Schwann cells, Proc. International Symposium on Physiomics p.71. [Taipei. Nov. 1-2, 2013]. 2013. |
| Chan Y.S., Developmental assembly of neural correlates for head directions, [International Symposium on Physiomics Taipei, Taiwan. Nov. 1-2, 2013]. 2013. |
| Chan Y.S., DE NOGUEIRA BOTELHO F.P., CHEN W., SHI W., Ma C.W., Lai C.H. and Shum D.K.Y., Developmental assembly of neural correlates for head directions, Proc. International Symposium on Physiomics p. 8. [Taipei. Nov 1-2, 2013]. 2013. |
| Chan Y.S., CHEN W., Ma C.W., SHI W., DE NOGUEIRA BOTELHO F.P., Lai C.H. and Shum D.K.Y., GABAergic transmission in the critical period impacts on the thalamic spatial map and navigation behaviour, Society Neuroscience Abstract (USA), 164.10/MM2. 2013. |
| Chan Y.S., International Journal of Brain Science . 2013. |
| Chan Y.S., Int’l Journal of Experimental & Clincal Physiology . 2013. |
| Chan Y.S., CHEN W., Ma C.W., SHI W., DE NOGUEIRA BOTELHO F.P., Lai C.H. and Shum D.K.Y., Plasticity of GABAergic synapses in the developing vestibular nucleus governs the expression of spatial navigation in mature rats, Soc. Neuroscience Abstract (USA) 164.10. 2013. |
| Chan Y.S., Plasticity of neural correlates for spatial coding, [NeuroTalk 2014. Nanjing. May 16-18, 2014]. 2014. |
| Chan Y.S., Plasticity of neural correlates for spatial coding, Proceedings of 5th World Congress of NeuroTalk p.42. [Naning May 16-18, 2014]. 2014. |
| Chan Y.S., Plasticity of the neural network for spatial recognition, International Conference on Advanced Research: Physiology [Singapore. July 21-22, 2014]. 2014. |
| DE NOGUEIRA BOTELHO F.P., Lai C.H. and Chan Y.S., BDNF advanced postnatal emergence of graviceptive behavior in rats by enhancing neonatal excitatory GABAergic transmission, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association35. 2014. |
| DE NOGUEIRA BOTELHO F.P., Lai C.H. and Chan Y.S., Brain derived neurotrophic factor-mediated GABAergic transmission in the vestibular nucleus modifies developmental acquisition of graviceptive behavior, Proc. 37th Int’l Congress of International Union of Physiological Sciences PCB119. 2013. |
| DE NOGUEIRA BOTELHO F.P., Ma C.W., Lai C.H. and Chan Y.S., Brain-derived neurotrophic factor (BDNF) advanced postnatal emergence of graviceptive behaviour in rats by enhancing neonatal excitatory GABAergic transmission, Abstracts of Physiology Symposium 2014 & Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 35. 2014. |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., 5-HT modulates synaptic transmission in vestibular nucleus of rats, Soc. Neuroscience Abstract (USA) 798.12 . 2013. |
| Han L. and Chan Y.S., Characterization of neurons in medial vestibular nucleus of VGAT-Venus transgenic mouse, Abstracts of 9th Int’l Symp. on Healthy Aging: Aging with Confidence 73. 2014. |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., Serotonergic regulation of synaptic strength in rat medial vestibular nucleus, Proc. International Symposium on Physiomics p. 73. 2013. |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., Serotoninergic control of synaptic transmission in rat medial vestibular nucleus, Journal of Neurochemistry, 130 Suppl 1: 28. 2014. |
| JIANG Q., SHI W., DE NOGUEIRA BOTELHO F.P., Ma C.W., Lai C.H., Shum D.K.Y. and Chan Y.S., Developmental modulation of long-term plasticity at vestibular GABAergic synapses, Journal of Neurochemistry, 130 Suppl 1: 65. 2014. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Best Poster Presentation Award, 9th Pan Pacific Connective Tissue Societies Symposium. 2013. 2013. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Certificate of Merit (Oral Presentation of poster), Physiology Symposium 2014 & Joint Scientific Conference of HKSN & BPHK.2014. 2014. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Outstanding Abstract Prize (Poster Category) , Ninth International Symposium on Healthy Aging. 2014. 2014. |
| KWAN P.Y., Ma C.W., Shum D.K.Y. and Chan Y.S., Perineuronal chondroitin sulfates and semaphorin 3A regulate postnatal maturation of the vestibular circuit for gravity detection, Abstracts of 9th Pan Pacific Connective Tissue Societies Symposium. 2013. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Postnatal Maturation of the Vestibular Circuit for Gravity Detection by under the Regulation of Perineuronal Chondroitin Sulfates and Semaphorin 3A , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Regulatory role of perineuronal nets and semaphorin3A in the developmental maturation of the central vestibular circuitry, Abstracts of 9th FENS Forum of Neuroscience,2454. 2014. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Regulatory role of perineuronal nets and semaphoring 3A in the developmental maturation of the central vestibular circuitry, The 9th Federation of European Neuroscience Societies Forum of Neuroscience. 2014. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Semaphorin 3A Associated with Chondroitin Sulfates on Perineuronal Nets Regulates Developmental Maturation of the Central Vestibular Circuitry. , Ninth International Symposium on Healthy Aging. 2014. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Semaphorin 3A and chondroitin sulfate proteoglycan networks of perineuronal nets regulate developing central vestibular circuitry, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association69. 2014. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Semaphorin 3A and chondroitin sulphate proteoglycan networks of perineuronal nets regulate the developing central vestibular circuitry, Abstracts of Physiology Symposium 2014 & Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 69. 2014. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Semaphorin3A, Associated with Perineuronal Nets, Regulates the Development of the Maturation of the Central Vestibular Circuitry, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., The regulatory role of perineuronal nets and semaphorin 3A in the developmental maturation of the central vestibular circuitry, Abstracts of 9th Int’l Symp. on Healthy Aging: 75. 2014. |
| Kwan P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Postnatal chondroitin sulfates and semaphoring 3A regulate postnatal maturation of the vestibular circuit for gravity detection, Abstracts of 9th Pan Pacific Connective Tissue Societies Symposium P30. [HK. Nov. 24-27, 2013]. 2013. |
| Kwan P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Postnatal maturation of the vestibular circuit for gravity detection is regulated by perineuronal semaphoring 3A and chondroitin sulfates, Proc. International Symposium on Physiomics p.74. 2013. |
| Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Chondroitinase ABC-I and -II crosslinked chitosan beads improve axonal regrowth in CSPG-enriched astrocyte culture, Ninth International Symposium on Healthy Aging. 2014. |
| Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Chondroitinase ABC-I and -II crosslinked chitosan beads improve axonal regrowth in CSPG-enriched astrocyte culture, Abstracts of 9th Int’l Symp. on Healthy Aging: Aging with Confidence: 73. 2014. |
| Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Chondroitinase ABC-I and -II linked chitosan microbeads improve axonal regrowth in CSPG-upregulated astrocyte culture, Physiology Symposium 2014 & Joint Scientific Conference of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong. 2014. |
| LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Chan Y.S., Cheung K.H. and Fung M.L., Mechanisms of Lycium barbarum polysaccharides against spatial memory deficits in rats exposed to chronic intermittent hpoxia, Proc. International Symposium on Physiomics p.75. 2013. |
| LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Cheung K.H., Chan Y.S. and Fung M.L., Neuroprotective mechanisms of Lycium barbarum polysaccharides against spatial memory impairment induced by chronic intermittent hypoxia, The Ninth International Symposium on Healthy Aging – Aging with Confidence, OP7, 3/2014. |
| LAM K.S.F., Lai C.H. and Chan Y.S., Effect of early blockade of KCC2 on the critical period of the developing vestibular nucleus, Abstracts of 9th Int’l Symp. on Healthy Aging: Aging with Confidence: 66. 2014. |
| LAM K.S.F., DE NOGUEIRA BOTELHO F.P., Ma C.W., Lai C.H. and Chan Y.S., KCC2 co-transporter of vestibular nuclear neurons regulates the developmental expression of vestibular functions, Abstracts of Physiology Symposium 2014 & Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 70. 2014. |
| LAU W.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Expression of heparanase 1 and heparanase 2 at the hippocampus, Abstracts of 9th FENS Forum of Neuroscience777. [Milan, Italy. July 5-9, 2014] . 2014. |
| LAU W.Y., CHAM W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Expression of heparanase 1 and heparanase 2 at the hippocampus, The 9th Federation of European Neuroscience Societies Forum of Neuroscience. 2014. |
| LAU W.Y., CHAM W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Neuronal expression of heparanase 1 and heparanase 2, Abstracts of Physiology Symposium 2014 & Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 71. 2014. |
| LAU W.Y., CHAM W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 71, Neuronal expression of heparanase 1 and heparanase 2. 2014. |
| LEUNG H.Y., TSUI Y.P., Tai E.W.Y., Chan Y.S. and Shum D.K.Y., Roles of neuregulin 1 type III in the ex vivo generation of fate committed schwann cells from bone marrow stromal cells, European meeting on Glial Cells in Health and Disease. 2013. |
| Leung H.Y., Tsui Y.P., Shea G.K.H., TAI W.Y.E., Chan Y.S. and Shum D.K.Y., Roles of neuregulin 1 type III in the ex vivo generation of fate committed schwann cells from bone marrow stromal cells, The 11th European Meeting on Glial Cells in Health and Disease (GLIA 2013). 2013. |
| Leung K.H.Y., Tsui Y.P., SHEA G.K.H., TAI W.Y.E., Chan Y.S. and Shum D.K.Y., Roles of neuregulin 1 type III in the ex vivo generation of fate committed Schwann cells from bone marrow stromal cells. (T06-02B), Glia 61 (Suppl): S97. 2013. |
| Li C., Lai C.H. and Chan Y.S., Dorsomedial cell column mediates the spatial signals of horizontal translation in rats, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 72. 2014. |
| Lui C.N.P., Tsui Y.P., Ho A.S.L., Shum D.K.Y., Chan Y.S., Wu C.T., Li H.W., Tsang E.S.C. and Yung K.K.L., Neural Stem Cells Harvested from Live Brains by Antibody-Conjugated Magnetic Nanoparticles, Angewandte Chemie International Edition. 2013, 52: 12298–12302. |
| Ma C.W., Han L., Cham W.C., Chan Y.S. and Shum D.K.Y., Neuronal proheparanase regulates synaptic function of the central vestibular system, Abstracts of 9th FENS Forum of Neuroscience 1603. 2014. |
| Ma C.W., Lai C.H., DE NOGUEIRA BOTELHO F.P., Shum D.K.Y. and Chan Y.S., Development of neural correlates of linear motion in the rat vestibular nucleus, Acta Physiologica Sinica. 2014, 66: 37-46. |
| Ma C.W., Han L., CHAM W.C., Chan Y.S. and Shum D.K.Y., Neuronal proheparanase regulates synaptic function of the central vestibular system, The 9th Federation of European Neuroscience Societies Forum of Neuroscience. 2014. |
| Ma C.W., Chan Y.S. and Shum D.K.Y., Perineuronal chondroitin sulfates regulate vestibular plasticity during development, Proc. Int’l Congress of Proteoglycans p.81. 2013. |
| Ma C.W., Lam Y.L., Cham W.C., Chan Y.S. and Shum D.K.Y., Regulatory role of neuronal proheparanase in synaptic plasticity, Proc. 37th Int’l Congress of International Union of Physiological Sciences PCB118. 2013. |
| SHI W., HU H., Shum D.K.Y. and Chan Y.S., Endocannabinoid modulates developmental plasticity of vestibular synapses and the expression of vestibular behavior in rats, Proc. 37th Int’l Congress of International Union of Physiological Sciences PCB113. [Birmingham, U.K. July 21-26, 2013]. 2013. |
| SHI W., Ma C.W., Shum D.K.Y. and Chan Y.S., Endocannabinoid regulates long-term synaptic plasticity contributing to the acquisition of vestibular behavior during postnatal development, Abstracts of Physiology Symposium 2014 & Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 76. 2014. |
| SHI W., Ma C.W., Shum D.K.Y. and Chan Y.S., Endocannabinoid regulates long-term synaptic plasticity contributing to the acquisition of vestibular behavior during postnatal development, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 76. 2014. |
| SHI W., Ma C.W., Shum D.K.Y. and Chan Y.S., Endocannabinoid regulates the efficacy ofof vestibular inhibitory synapses contributing to the expression of gravity-detection behavior in developing rats, Proc. 10th Biennial Conference of Chinese Society for Neuroscience S15. 2013. |
| SHI W., Ma C.W., Shum D.K.Y. and Chan Y.S., The role of endocannabinoid in long-term plasticity of vestibular GABAergic synapses and behavioral outcome in developing rats., Soc. Neuroscience Abstract (USA) 129.11. [San Diego. Nov. 9-13, 2013]. 2013. |
| SHI W., Ma C.W., Shum D.K.Y. and Chan Y.S., The role of endocannabinoid in long-term plasticity of vestibular GABAergic synapses and behavioral outcome in developing rats, Society Neuroscience Abstract (USA), 129.11/C32. 2013. |
| Shea G.K.H., Shum D.K.Y. and Chan Y.S., Guidance of DRG Neurons on the Fate Determination of Bone Marrow Stromal Cells to Myelinating Glia , In: The University of Hong Kong, 18th Research Postgraduate Symposium. 2013. |
| Shea G.K.H., TAI W.Y.E., Chan Y.S. and Shum D.K.Y., Targeting Notch signalling to generate bone marrow-derived Schwann cells for transplantation in spinal cord injury, The 33rd Annual Congress of the HKOA. 2013. |
| Shum D.K.Y., TAI W.Y.E., SHEA G.K.H., Tsui Y.P. and Chan Y.S., An emerging role of Notch signaling in the switch to fate commitment of bone marrow-derived Schwann cells, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association P.32. 2014. |
| Shum D.K.Y. and Chan Y.S., Emerging role of perineural chondroitin sulfates and semaphorin 3A in maturation of the central vestibular circuitry, Gordon Research Conference on Proteoglycans: Diverse Regulators of Health and Disease[Andover, NH, USA. July 9-11, 2014]. 2014. |
| Shum D.K.Y., Ma C.W., Lam Y.L., Chan W.C., Han L. and Chan Y.S., Novel role of proheparanase in regulating synaptic function in the central vestibular circuitry, Journal of Neurochemistry, 130 Suppl 1: 20. [11th Biennial Meeting of Asia-Pacific Society for Neurochemistry Kaohsiung. August 23-26, 2014. |
| Shum D.K.Y., Tsui Y.P., Cai S., TAI W.Y.E. and Chan Y.S., Oligodendrocyte precursors – in vitro derivation from bone marrow stromal cells and use in remyelination therapy, Proc. 10th Biennial Conference of Chinese Society for Neuroscience 15-01. [Beijing, China. Sept. 20-22, 2013]. ~ Proc. 10~th^~~ Biennial Conference of Chinese Society for Neuroscience/~~15-01, 2013. |
| Shum D.K.Y., Tsui Y.P., TAI W.Y.E. and Chan Y.S., Towards remyelination therapy with oligodendrocyte precursor and Schwann cells derived from bone marrow stromal cells, Soc. Neuroscience Abstract (USA) 414.09. 2013. |
| TAI W.Y.E., SHEA G.K.H., Tsui Y.P., Leung H.Y., Chan Y.S. and Shum D.K.Y., Fate commitment of bone marrow-derived Schwann cells is guided by Notch and ErbB signaling, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 78. 2014. |
| TAI W.Y.E., SHEA G.K.H., Tsui Y.P., Leung H.Y., Chan Y.S. and Shum D.K.Y., Guidance of DRG neurons in fate determination of bone marrow derived Schwann cells, Abstracts of 9th FENS Forum of Neuroscience, 1307. 2014. |
| TAI W.Y.E., Shea G.K.H., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Notch Signaling in in vitro derivation of Schwann cells from bone marrow stromal cells, 11th European Meeting on Glial Cells in Health and Disease. 2013. |
| TAI W.Y.E., SHEA G.K.H., Tsui Y.P., Leung K.H.Y., Chan Y.S. and Shum D.K.Y., Notch signaling in in in vitro derivation of Schwann cells from bone marrow stromal cells. (T01-12B) Glia 61 (Suppl): S55, [XI European Meeting on Glial Cells in Health and Disease Berlin, Germany. July 3 - 6, 2013]. 2013. |
| TSANG K.H., Lai S.K., Li Q., Yung W.H., LIU H., Mak H.S., NG C.P., McAlonan G.M., Chan Y.S. and Chan S.Y., The Nucleosome Assembly Protein TSPYL2 Regulates the Expression of NMDA Receptor Subunits GluN2A and GluN2B, Scientific Reports. 2014, 4: 3654. |
| TUNG W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Nere guidance channel constructed by Schwann cell seeded aligned chitosan nanofiber, Journal of Neurochemistry, 130 Suppl 1: 49. 2014. |
| TUNG W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Oriented Schwann Cells Culture on Aligned Chitosan Nanofibers for Axonal Growth Guidance, 11th International Conference on Materials Chemistry: P056. 2013. |
| Tam K.W., Chan Y.S. and Shum D.K.Y., Improving the environment for axonal growth with use of recombinant chondroitinase ABC, Physiology Symposium 2014 & Joint Scientific Conference of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong. 2014. |
| Tam K.W., Chan Y.S. and Shum D.K.Y., Improving the environment for axonal growth with use of recombinant chondroitinase ABC, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 78. 2014. |
| Tam K.W., Chan Y.S. and Shum D.K.Y., Overcoming the chondroitin sulphate barrier in injured nerve: the efficacy of chondroitinase ABC treatment and the potency of disaccharide products, Ninth International Symposium on Healthy Aging. 2014. |
| Tam K.W., Chan Y.S. and Shum D.K.Y., The dual role of combinatorial chondoritinase in overcoming the chondroitin sulfate barrier, Proc. 10th Biennial Conference of Chinese Society for Neuroscience P184. 2013. |
| Tam K.W., Chan Y.S. and Shum D.K.Y., The dual role of combinatorial chondoritinase in overcoming the chondroitin sulfate barrier, Proc. Int’l Conference on Proteoglycans p. 39. [ProteoGlycans 2013 Frankfurt/ Main, Germany. August 25-29, 2013]. 2013. |
| Tsui Y.P., Li R.S., Lo A.C.Y., Chan Y.S. and Shum D.K.Y., Derivation of oligodendrocyte precursor cells from bone marrow stromal cells for remyelination therapy, Proc. 37th Int’l Congress of International Union of Physiological Sciences PCB116. 2013. |
| Tsui Y.P., TAI W.Y.E., Shum D.K.Y. and Chan Y.S., Divergent routes for derivation of alternative glial cell fate from bone marrow stromal cells of adult rats for remyelination, 12th Annual Meeting of the International Society for Stem Cell Research. 2014. |
| Tsui Y.P., TAI W.Y.E., Chan Y.S. and Shum D.K.Y., Divergent routes for derivation of alternative glial cell fate from bone marrow stromal cells of adult rats for remyelination, Abstracts of 12th Annual Meeting of International Society for Stem Cell Research: 470. [Vancouver, Canada. June 18-21, 2014]. 2014. |
| Tsui Y.P., TAI W.Y.E., Chan Y.S. and Shum D.K.Y., From the marrow to two glial lineages—Derivation of oligodendrocyte precursors and Schwann cells from bone marrow stromal cells for remyelination therapy, Cold Spring Harbor Asia/International Society for Stem Cell Research (CSHA/ISSCR) Joint Conference on Stem Cells in Science and Medicine. 2013. |
| Tsui Y.P., Li R., Lo A.C.Y., Chan Y.S. and Shum D.K.Y., Towards remyelination therapy: Derivation of oligodendrocyte precursors from adult bone marrow stromal cells. (T09-11B) , Glia 61 (Suppl): S151. 2013. |
| Tsui Y.P., TAI W.Y.E., Shum D.K.Y. and Chan Y.S., Towards remyelination therapy: Divergent routes for derivation of alternative glial cell fate from bone marrow stromal cells of adult rats, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 80. 2014. |
| Tsui Y.P., Li S.Y., Lo A.C.Y., Chan Y.S. and Shum D.K.Y., Towards remyelination therapy: derivation of oligodendrocyte precursors from adult bone marrow stromal cells, The 11th European Meeting on Glial Cells in Health and Disease (GLIA 2013). 2013. |
| Tsui Y.P., TAI W.Y.E., Shum D.K.Y. and Chan Y.S., Towards remyelination therapy: divergent routes for derivation of alternative glial cell fate from bone marrow stromal cells of adult rats, Physiology Symposium 2014 & Joint Scientific Conference of HKSN & BPHK. 2014. |
| Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Aligned chitosan nanofibers seeded with Schwann cells for construction of a nerve guidance channel, Ninth International Symposium on Healthy Aging. 2014. |
| Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Construction of nerve guidance channel with use of Schwann cell seeded aligned chitosan nanofibers, Physiology Symposium 2014 & Joint Scientific Conference of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong. 2014. |
| Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Construction of nerve guidance channel with use of Schwann cell seeded aligned chitosan nanofibers, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 81. 2014. |
| Tung W.T., Tam K.W., Chan Y.S. and Kwok L.F., Use of Schwann cell-seeded nanofiber as nerve conduit, 3D Cell Culture 2014 - Advanced Model Systems, Applications & Enabling Technologies. 2014. |
| WANG B., LIU Y., Wong Y.M.E., Chu K.H., Chan Y.S., Hui C.C. and Sham M.H., Irx3 and Irx5 Regulate Cochlear Hair Cell Specification and Differentiation , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013. |
| WONG M.K., Li M., Chan Y.S. and Shum D.K.Y., Expression of Chondroitin Sulfotransferase in Cranial Motor Neurons for Cell Migration in Rat Embryonic Hindbrain, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014. |
| WONG M.K., Li M., Chan Y.S. and Shum D.K.Y., Varying Expression of Chondroitin Sulfotransferases for Cranial Motor Neuron Migration in Rat Hindbrain Development , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013 . 2013. |
| Wong M.K., Li M., Chan Y.S. and Shum D.K.Y., Chondroitin sulfotransferase expression pattern for the regulation of cranial motor neuron migration in rat embryonic hindbrain, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 83. 2014. |
| Wong M.K., Li M., Chan Y.S. and Shum D.K.Y., Chondroitine sulfotransferase expression pattern in migrating motor neurons of the rat embryonic hindbrain, Soc. Neuroscience Abstract (USA)219.07. 2013. |
| Wong M.K., Li M., Chan Y.S. and Shum D.K.Y., Control of cranial motor neuron migration by divergent expression of chondroitin sulfotransferases in rat hindbrain development, Proc. 9th Pan Pacific Connective Tissue Societies Symposium P68. 2013. |
| Wong M.K., Li M., Li M., Chan Y.S. and Shum D.K.Y., Control of cranial motor neuron migration by divergent expression of chondroitin sulfotransferases in rat hindbrain development, Proc. International Symposium on Physiomics p.79. 2013. |
| Wong M.K., Li M., Chan Y.S. and Shum D.K.Y., Dynamics of chondroitin sulfotransferase expression for cranial motor neuron migration in rat hindbrain development, Abstracts of 9th FENS Forum of Neuroscience, 2470. 2014. |
| Researcher : Chen J |
| Project Title: | Molecular Mechanism of Gating Defects in DeltaF508-CFTR Cl– Channel |
| Investigator(s): | Chen J |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 10/2011 |
| Completion Date: | 09/2013 |
| Project Title: | Effects of Influenza A (H1N1) Virus Infection on Ion Transport of Pig Tracheal Epithelia |
| Investigator(s): | Chen J, Chen H, Li GR |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2013 |
| Project Title: | CFTR Activation by Regional Phosphorylation on the R Domain |
| Investigator(s): | Chen J |
| Department: | Physiology |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 09/2013 |
| Researcher : Chen K |
| List of Research Outputs |
| Chen K., Sun H. and Li G.R., Acacetin is a unique natural flavone blocking multiple atrial-selective channels for anti-atrial fibrillation, Cardiac Arrhythmias 2014/The 12th IDSS on Innovations in Technology, Treatment and Prevention of Cardiac Arrhythmias, Tel Aviv, Israel. Mar 3-5.. 2014. |
| Chen K., Xu X.H., Liu Y., Hu Y., Jin M.W. and Li G.R., TRPM7 channels regulate proliferation and adipogenesis in 3T3-L1 Preadipocytes, J Cell Physiol. 2014, 229(1): 60-67. |
| Researcher : Cheung KH |
| Project Title: | Molecular Mechanism of Capacitative Calcium Entry Deficits in Presenilin Mutations and Its Role in Alzheimers Disease Pathogenesis |
| Investigator(s): | Cheung KH, Chan YS, Lee HC |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2011 |
| Project Title: | PS-TPC2 interaction: Mechanisms for autophay pathology in AD |
| Investigator(s): | Cheung KH |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2012 |
| Completion Date: | 05/2014 |
| Project Title: | Nuclear membrane electrophysiology of Ryanodine Receptor Channel |
| Investigator(s): | Cheung KH |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2013 |
| Project Title: | Nuclear Membrane Electrophysiology of Ryanodine Receptor And Its Regulation by cADPR |
| Investigator(s): | Cheung KH, Chen J |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2013 |
| Project Title: | Role of intracellular calcium release channels in Asthma pathogenesis |
| Investigator(s): | Cheung KH, Leung GPH |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| List of Research Outputs |
| HAO B., LU Y., WANG Q., GUO W., Cheung K.H. and Yue J., Role of STIM1 in Survival and Neural Differentiation of Mouse Embryonic Stem Cells Independent of Orai1-Mediated Ca2+ Entry., Stem Cell Res. 2013, Epub ahead of print. |
| Joseph J.D., Peng Y., Mak D.D.O., Cheung K.H., Vais H., Foskett J.K. and Wei H., General Anesthetic Isoflurane Modulates Inositol 1,4,5-Trisphosphate Receptor Calcium Channel Opening, Anesthesiology. 2014, 1. |
| LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Cheung K.H. and Fung M.L., Lycium barbarum polysaccharides facilitate hippocampal neurogenesis induced by chronic intermittent hypoxia in rats, 18th Research Postgraduate Symposium, HKU, P5.12, 12/2013. |
| LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Chan Y.S., Cheung K.H. and Fung M.L., Mechanisms of Lycium barbarum polysaccharides against spatial memory deficits in rats exposed to chronic intermittent hpoxia, Proc. International Symposium on Physiomics p.75. 2013. |
| LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Cheung K.H. and Fung M.L., Mechanistic effects of Lycium barbarum polysaccharides against rat hippocampal injuries induced by chronic intermittent hypoxia, The 17th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, CP3, 11/2013. (Journal of the Hong Kong College of Cardiology, 21(2):69, CP3, 2013). 2013. |
| LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Cheung K.H., Chan Y.S. and Fung M.L., Neuroprotective mechanisms of Lycium barbarum polysaccharides against spatial memory impairment induced by chronic intermittent hypoxia, The Ninth International Symposium on Healthy Aging – Aging with Confidence, OP7, 3/2014. |
| Liao S., Cheung K.H., O W.S. and Tang F., Adrenomedullin Increases the Short-Circuit Current in the Mouse Seminal Vesicle: Actions on Chloride Secretion, Biology of Reproduction. 2014. |
| Liao S., Cheung K.H., Cheung M.P.L., To J.Y.T., O W.S. and Tang F., Adrenomedullin increased the short-circuit current in the pig oviduct through chloride channels via the CGRP receptor: Mediation by cAMP and calcium ions but not by nitric oxide, Biology of Reproduction. 2013, 89(4): 99, 1-6. |
| Liao S., Cheung K.H., Cheung M.P.L., Wong P.F., O W.S. and Tang F., Adrenomedullin increases the short-circuit current in the rat prostate: Receptors, chloride channels, the effects of cAMP and calcium ions and implications on fluid secretion, Andrology. 2014, 2: 474-480. |
| Mak D.O.D., Vais H., Cheung K.H. and Foskett J.K., Isolating Nuclei from Cultured Cells for Patch-Clamp Electrophysiology of Intracellular Ca2+ Channels, Cold Spring Harbor Protocols. 2013, 2013: 880-884. |
| Mak D.O.D., Vais H., Cheung K.H. and Foskett J.K., Nuclear Patch-Clamp Electrophysiology of Ca2+ Channels, Cold Spring Harbor Protocols. 2013, 2013: 885-891. |
| Mak D.O.D., Vais H., Cheung K.H. and Foskett J.K., Patch-Clamp Electrophysiology of Intracellular Ca2+ Channels, Cold Spring Harbor Protocols. 2013, 2013: 787-797. |
| Researcher : Chow MZY |
| Project Title: | Epigenetic regulation of the electrophysiological profile of human embryonic stem cell-derived ventricular cardiomyocytes |
| Investigator(s): | Chow MZY, Li RA |
| Department: | Medicine |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2013 |
| Completion Date: | 06/2014 |
| List of Research Outputs |
| Chow M.Z.Y., Geng L., Kong M.C.W., Keung W.W.Y., Fung J.C., Boheler K.R. and Li R.A., Epigenetic regulation of the electrophysiological phenotype of human embryonic stem cell (hESC)-derived ventricular cardiomyocytes: Insights into driven maturation and hypertrophic growth., Stem Cells Dev. . 2013. |
| Researcher : DE NOGUEIRA BOTELHO FP |
| List of Research Outputs |
| CHEN W., Ma C.W., NG K.P., HU H., DE NOGUEIRA BOTELHO F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., Early postnatal disturbance of inhibitory transmission in the vestibular nucleus impacts on the thalamic spatial map and navigation behaviors, Abstracts of Physiology Symposium 2014 & Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 61. 2014. |
| CHEN W., DE NOGUEIRA BOTELHO F.P., Ma C.W., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of GABAergic synapses in the vestibular nucleus during a postnatal critical period impacts on the acquisition on spatial recognition, Proc. International Symposium on Physiomics p. 72.. 2013. |
| CHEN W., Ma C.W., DE NOGUEIRA BOTELHO F.P., SHI W., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of GABAergic synapses in the vestibular nucleus during a postnatal critical period impacts on the acquisition on spatial recognition, Proc.10th Biennial Conference of Chinese Society for Neuroscience S05. [Beijing. Sept. 20-22, 2013]. 2013. |
| CHEN W., Ma C.W., HU H., DE NOGUEIRA BOTELHO F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of the plasticity at GABAeric synapses in the vestibular nucleus during a critical period impacts on the thalamic spatial network and navigation behavior, Abstracts of 9th Int’l Symp. on Healthy Aging: Aging with Confidence51. 2014. |
| Chan Y.S., DE NOGUEIRA BOTELHO F.P., CHEN W., SHI W., Ma C.W., Lai C.H. and Shum D.K.Y., Developmental assembly of neural correlates for head directions, Proc. International Symposium on Physiomics p. 8. [Taipei. Nov 1-2, 2013]. 2013. |
| Chan Y.S., CHEN W., Ma C.W., SHI W., DE NOGUEIRA BOTELHO F.P., Lai C.H. and Shum D.K.Y., GABAergic transmission in the critical period impacts on the thalamic spatial map and navigation behaviour, Society Neuroscience Abstract (USA), 164.10/MM2. 2013. |
| Chan Y.S., CHEN W., Ma C.W., SHI W., DE NOGUEIRA BOTELHO F.P., Lai C.H. and Shum D.K.Y., Plasticity of GABAergic synapses in the developing vestibular nucleus governs the expression of spatial navigation in mature rats, Soc. Neuroscience Abstract (USA) 164.10. 2013. |
| DE NOGUEIRA BOTELHO F.P., Lai C.H. and Chan Y.S., BDNF advanced postnatal emergence of graviceptive behavior in rats by enhancing neonatal excitatory GABAergic transmission, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association35. 2014. |
| DE NOGUEIRA BOTELHO F.P., Lai C.H. and Chan Y.S., Brain derived neurotrophic factor-mediated GABAergic transmission in the vestibular nucleus modifies developmental acquisition of graviceptive behavior, Proc. 37th Int’l Congress of International Union of Physiological Sciences PCB119. 2013. |
| DE NOGUEIRA BOTELHO F.P., Ma C.W., Lai C.H. and Chan Y.S., Brain-derived neurotrophic factor (BDNF) advanced postnatal emergence of graviceptive behaviour in rats by enhancing neonatal excitatory GABAergic transmission, Abstracts of Physiology Symposium 2014 & Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 35. 2014. |
| JIANG Q., SHI W., DE NOGUEIRA BOTELHO F.P., Ma C.W., Lai C.H., Shum D.K.Y. and Chan Y.S., Developmental modulation of long-term plasticity at vestibular GABAergic synapses, Journal of Neurochemistry, 130 Suppl 1: 65. 2014. |
| LAM K.S.F., DE NOGUEIRA BOTELHO F.P., Ma C.W., Lai C.H. and Chan Y.S., KCC2 co-transporter of vestibular nuclear neurons regulates the developmental expression of vestibular functions, Abstracts of Physiology Symposium 2014 & Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 70. 2014. |
| Ma C.W., Lai C.H., DE NOGUEIRA BOTELHO F.P., Shum D.K.Y. and Chan Y.S., Development of neural correlates of linear motion in the rat vestibular nucleus, Acta Physiologica Sinica. 2014, 66: 37-46. |
| Researcher : Fung ML |
| Project Title: | Pathophysiological roles of pro-inflammatory cytokines in the carotid body in intermittent hypoxia |
| Investigator(s): | Fung ML, Tipoe GL |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2011 |
| Project Title: | Pathophysiological mechanisms of myocardial dysfunction in intermittent hypoxia: roles of oxidative stress in impaired calcium homeostasis |
| Investigator(s): | Fung ML |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2012 |
| Completion Date: | 05/2014 |
| Project Title: | Neuroprotective effect of Lycium barbarum polysaccharides against hippocampal apoptosis induced by chronic intermittent hypoxia in rats |
| Investigator(s): | Fung ML |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2013 |
| Project Title: | Protective effect of Lycium barbarum polysaccharides on spatial memory deficits induced by intermittent hypoxia in rats |
| Investigator(s): | Fung ML |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | 19th International meeting of ISAC The International Society for Arterial Chemoreception; Nitric oxide deficit is part of the maladaptive paracrine-autocrine response of the carotid body to intermittent hypoxia in sleep apnea |
| Investigator(s): | Fung ML |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2014 |
| Completion Date: | 07/2014 |
| List of Research Outputs |
| Fung M.L., Tipoe G.L. and Leung P.S., Mechanisms of maladaptive responses of peripheral chemoreceptors to intermittent hypoxia in sleep-disordered breathing., Acta Physiologica Sinica. 2014, 66(1): 23-29. |
| GUO R., Lin B., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H. and Tipoe G.L., M30 multi-functional drug reduces apoptosis, oxidative stress and inflammation in CCl4 -induced acute liver injury animal model, The Physiology Symposium 2014, P9, 6/2014, 2014. |
| GUO R., Lin B., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H. and Tipoe G.L., M30 multi-functional drug reduces apoptosis, oxidative stress and inflammation in CCl4-induced acute liver injury animal model, The Ninth International Symposium on Healthy Aging – Aging with Confidence, P64, 3/2014. |
| Hung M.W., Kravtsov G.M., Lau C.F., Poon A.M.S., Tipoe G.L. and Fung M.L., Melatonin ameliorates endothelial dysfunction, vascular inflammation, and systemic hypertension in rats with chronic intermittent hypoxia, Journal of Pineal Research. 2013, 55: 247-256. |
| LAM C.S., Liu Y.Y., Tipoe G.L. and Fung M.L., Induction of depressive-like behavior in a rat model of obstructive sleep apnea, The Physiology Symposium 2014, N61, 6/2014. |
| LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Cheung K.H. and Fung M.L., Lycium barbarum polysaccharides facilitate hippocampal neurogenesis induced by chronic intermittent hypoxia in rats, 18th Research Postgraduate Symposium, HKU, P5.12, 12/2013. |
| LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Chan Y.S., Cheung K.H. and Fung M.L., Mechanisms of Lycium barbarum polysaccharides against spatial memory deficits in rats exposed to chronic intermittent hpoxia, Proc. International Symposium on Physiomics p.75. 2013. |
| LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Cheung K.H. and Fung M.L., Mechanistic effects of Lycium barbarum polysaccharides against rat hippocampal injuries induced by chronic intermittent hypoxia, The 17th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, CP3, 11/2013. (Journal of the Hong Kong College of Cardiology, 21(2):69, CP3, 2013). 2013. |
| LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Cheung K.H., Chan Y.S. and Fung M.L., Neuroprotective mechanisms of Lycium barbarum polysaccharides against spatial memory impairment induced by chronic intermittent hypoxia, The Ninth International Symposium on Healthy Aging – Aging with Confidence, OP7, 3/2014. |
| Lam S.S.Y., liu Y., Ng K.M., Liong E.C., Tipoe G.L., Leung P.S. and Fung M.L., Upregulation of a local renin-angiotensin system in the rat carotid body during chronic intermittent hypoxia, Experimental Physiology. 2014, 99: 220-231. |
| PAN J., GUO R., Liong E.C., Tipoe G.L. and Fung M.L., Intermittent hypoxia exacerbates lipid accumulation, inflammation and apoptosis via NADPH oxidase in a cell model of non-alcoholic fatty liver disease, The Physiology Symposium 2014, P27, 6/2014. |
| PAN J., GUO R., Liong E.C., Tipoe G.L. and Fung M.L., Oxidative stress induced by chronic intermittent hypoxia aggravates hepatic inflammation in nonalcoholic fatty liver disease (NAFLD), 18th Research Postgraduate Symposium, HKU P5.17, 12/2013. |
| PAN J., GUO R., Liong E.C., Tipoe G.L. and Fung M.L., Oxidative stress induced by intermittent hypoxia aggravates lipid accumulation and autophagy in a cell model of nonalcoholic fatty liver disease (NAFLD), The Ninth International Symposium on Healthy Aging – Aging with Confidence, P35, 3/2014. |
| PAN J., GUO R., Liong E.C., Tipoe G.L. and Fung M.L., Oxidative stress induced by intermittent hypoxia exacerbates lipid accumulation and inflammation in HepG2 cells. 2013 International Symposium on Physiomics &Taiwan, Hong Kong Physiology Symposium. Taipei, Taiwan. 2013. |
| PAN J., GUO R., Liong E.C., Tipoe G.L. and Fung M.L., Oxidative stress induced by intermittent hypoxia exacerbates lipid accumulation and inflammation in a cell model of non-alcoholic steatohepatitis. The 17th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, OP3, 11/2013, Journal of the Hong Kong College of Cardiology. 2013, 21(2):65. |
| WU F., GUO R., Tipoe G.L. and Fung M.L., Exercise attenuates left ventricular hypertrophy induced by high fat diet in rats, 18th Research Postgraduate Symposium, HKU, P5.25, 12/2013.. 2013. |
| WU F., GUO R., PAN J., Tipoe G.L. and Fung M.L., Involvement of autophagy in the effect of exercise on left ventricular hypertrophy induced by high fat diet in rats. The 17th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, CP5, Journal of the Hong Kong College of Cardiology. 2013, 21(2):70. |
| WU F., GUO R., PAN J., Tipoe G.L. and Fung M.L., Potential role of autophagy in the effect of exercise on left ventricular hypertrophy induced by high fat diet in rats. 2013 International Symposium on Physiomics &Taiwan , Hong Kong Physiology Symposium. Taipei, Taiwan,. 2013. |
| Xiao J., Ho M.C.T., Liong E.C., Nanji A.A., Leung T.M., Lau T.Y.H., Fung M.L. and Tipoe G.L., Epigallocatechin gallate attenuates fibrosis, oxidative stress, and inflammation in non-alcoholic fatty liver disease rat model through TGF/SMAD, PI3 K/Akt/FoxO1, and NF-kappa B pathways, European Journal of Nutrition. 2014, 53(1): 187-199. |
| Xiao J., Liong E.C., Chang R.C.C., Fung M.L., Xu A.M., So K.F. and Tipoe G.L., Lycium barbarum polysaccharides protect rat liver from non-alcoholic steatohepatitis-induced injury, Nutrition and Diabetes, Doi:10.1038/nutd.2013.22. 2013, 3,e81. |
| Xiao J., Wang J., Xing F., Han T., Jiao R., Liong E.C., Fung M.L., So K.F. and Tipoe G.L., Zeaxanthin dipalmitate therapeutically improves hepatic functions in an alcoholic fatty liver disease model through modulating MAPK pathway, PLOS ONE. 2014, 9(4): e95214. |
| Researcher : GUO W |
| List of Research Outputs |
| HAO B., LU Y., WANG Q., GUO W., Cheung K.H. and Yue J., Role of STIM1 in Survival and Neural Differentiation of Mouse Embryonic Stem Cells Independent of Orai1-Mediated Ca2+ Entry., Stem Cell Res. 2013, Epub ahead of print. |
| Researcher : Graeff RM |
| List of Research Outputs |
| Graeff R.M. and Lee H.C., Determination of ADP-Ribosyl Cyclase Activity, Cyclic ADP-Ribose, and Nicotinic Acid Adenine Dinucleotide Phosphate in Tissue Extracts, In: Chris Gehring, Cyclic Nucleotide Signaling in Plants: Methods and Protocols, Methods in Molecular Biology. Springer, 2013, 1016: 39-56. |
| LU Y., HAO B., Graeff R.M., Wong W.M., Wu W. and Yue J., Two Pore Channel 2 (TPC2) Inhibits Autophagosomal-Lysosomal Fusion by Alkalinizing Lysosomal pH, J Biol Chem.. 2013, 288(33): 24247-63. |
| Researcher : HAO B |
| List of Research Outputs |
| HAO B., LU Y., WANG Q., GUO W., Cheung K.H. and Yue J., Role of STIM1 in Survival and Neural Differentiation of Mouse Embryonic Stem Cells Independent of Orai1-Mediated Ca2+ Entry., Stem Cell Res. 2013, Epub ahead of print. |
| LU Y., HAO B., Graeff R.M., Wong W.M., Wu W. and Yue J., Two Pore Channel 2 (TPC2) Inhibits Autophagosomal-Lysosomal Fusion by Alkalinizing Lysosomal pH, J Biol Chem.. 2013, 288(33): 24247-63. |
| Researcher : HU H |
| List of Research Outputs |
| CHEN W., Ma C.W., NG K.P., HU H., DE NOGUEIRA BOTELHO F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., Early postnatal disturbance of inhibitory transmission in the vestibular nucleus impacts on the thalamic spatial map and navigation behaviors, Abstracts of Physiology Symposium 2014 & Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 61. 2014. |
| CHEN W., Ma C.W., HU H., DE NOGUEIRA BOTELHO F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of the plasticity at GABAeric synapses in the vestibular nucleus during a critical period impacts on the thalamic spatial network and navigation behavior, Abstracts of 9th Int’l Symp. on Healthy Aging: Aging with Confidence51. 2014. |
| SHI W., HU H., Shum D.K.Y. and Chan Y.S., Endocannabinoid modulates developmental plasticity of vestibular synapses and the expression of vestibular behavior in rats, Proc. 37th Int’l Congress of International Union of Physiological Sciences PCB113. [Birmingham, U.K. July 21-26, 2013]. 2013. |
| Researcher : Han L |
| Project Title: | Monoaminergic control of synaptic functions in the vestibular nucleus |
| Investigator(s): | Han L, Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2013 |
| Completion Date: | 06/2014 |
| List of Research Outputs |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., 5-HT modulates synaptic transmission in vestibular nucleus of rats, Soc. Neuroscience Abstract (USA) 798.12 . 2013. |
| Han L. and Chan Y.S., Characterization of neurons in medial vestibular nucleus of VGAT-Venus transgenic mouse, Abstracts of 9th Int’l Symp. on Healthy Aging: Aging with Confidence 73. 2014. |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., Serotonergic regulation of synaptic strength in rat medial vestibular nucleus, Proc. International Symposium on Physiomics p. 73. 2013. |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., Serotoninergic control of synaptic transmission in rat medial vestibular nucleus, Journal of Neurochemistry, 130 Suppl 1: 28. 2014. |
| Ma C.W., Han L., Cham W.C., Chan Y.S. and Shum D.K.Y., Neuronal proheparanase regulates synaptic function of the central vestibular system, Abstracts of 9th FENS Forum of Neuroscience 1603. 2014. |
| Ma C.W., Han L., CHAM W.C., Chan Y.S. and Shum D.K.Y., Neuronal proheparanase regulates synaptic function of the central vestibular system, The 9th Federation of European Neuroscience Societies Forum of Neuroscience. 2014. |
| Shum D.K.Y., Ma C.W., Lam Y.L., Chan W.C., Han L. and Chan Y.S., Novel role of proheparanase in regulating synaptic function in the central vestibular circuitry, Journal of Neurochemistry, 130 Suppl 1: 20. [11th Biennial Meeting of Asia-Pacific Society for Neurochemistry Kaohsiung. August 23-26, 2014. |
| Researcher : Hao Q |
| Project Title: | Structural biology of sirtuins |
| Investigator(s): | Hao Q |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2010 |
| Completion Date: | 10/2013 |
| Project Title: | Engineering CD38 for Calcium Signaling |
| Investigator(s): | Hao Q |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2011 |
| Project Title: | Structure and Function of the TRPM2 channel |
| Investigator(s): | Hao Q, Kotaka M, Lee HC |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2012 |
| Project Title: | Structural Biology of Human PECAM-1 (CD31) in Cell Adhesion and Leukocyte Transmigration |
| Investigator(s): | Hao Q, Zhang H |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2012 |
| Project Title: | Liverpool-HKU Joint Symposium; Structural basis for novel post-translational modifications regulated by Sirtuins |
| Investigator(s): | Hao Q |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2013 |
| Completion Date: | 07/2013 |
| List of Research Outputs |
| Hao Q., Breakthrough in the application of X-ray Free Electron Laser in structural biology, Xiang Shan Scientific Conference (第474次香山科学会议). 2013. |
| Hao Q., Novel Protein Post-translational Modifications Revealed by the Crystal Structure of Sirt5, Asia Crystallography Association (AsCA’13). 2013. |
| Hao Q., Structural Basis for Novel Posttranslational Modifications regulated by Sirtuins, Liverpool-HKU Joint Symposium, Liverpool, UK. 2013. |
| Hao Q., Structure and Function of Human Sirtuins, International Workshop on Functional Conformational Changes in Complex Biological Systems. 2014. |
| Shrimp J.H., Hu M., Dong M., Wang B.S., MacDonald R., Jiang H., Hao Q., Yen A. and Lin H., Revealing CD38 Cellular Localization Using a Cell Permeable, Mechanism-Based Fluorescent Small-Molecule Probe, Journal of the American Chemical Society. 2014, 136: 5656-5663. |
| Researcher : JIANG Q |
| List of Research Outputs |
| JIANG Q., SHI W., DE NOGUEIRA BOTELHO F.P., Ma C.W., Lai C.H., Shum D.K.Y. and Chan Y.S., Developmental modulation of long-term plasticity at vestibular GABAergic synapses, Journal of Neurochemistry, 130 Suppl 1: 65. 2014. |
| Researcher : KWOK HCJ |
| List of Research Outputs |
| CHEUNG Y.W., KWOK H.C.J., LAW W.L., Watt R.M., Kotaka M. and Tanner J.A., Structural basis for discriminatory recognition of Plasmodium lactate dehydrogenase, Proceedings of the National Academy of Sciences USA. 2013, 110(40): 15967-15972. |
| KWOK H.C.J., Hui P.Y., Lescar J. and Kotaka M., Expression, purification, crystallization and preliminary X-ray analysis of full-length human RIG-I., Acta Crystallographica Section F: Structural Biology Communications. 2014, 70: 248-251. |
| Tanner J.A., Cheung Y.W., KWOK H.C.J., LAW W.L., ALBANO D.R.B., Fung Y.S., Watt R.M. and Kotaka M., Towards aptamer-mediated malaria diagnostics: structural insight into discriminatory molecular recognition by a DNA aptamer, Aptamers in Medicine and Perspectives, Naples, Italy . 2013. |
| Researcher : Keung WWY |
| Project Title: | Promoting maturation of hESC-derived cardiomyocytes: the interplay between mitochondria, calcium and reactive oxygen species |
| Investigator(s): | Keung WWY, Li RA |
| Department: | Medicine |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2013 |
| Completion Date: | 06/2014 |
| List of Research Outputs |
| Chow M.Z.Y., Geng L., Kong M.C.W., Keung W.W.Y., Fung J.C., Boheler K.R. and Li R.A., Epigenetic regulation of the electrophysiological phenotype of human embryonic stem cell (hESC)-derived ventricular cardiomyocytes: Insights into driven maturation and hypertrophic growth., Stem Cells Dev. . 2013. |
| Gao S., Serra D., Keung W.W.Y., Hegardt F.G. and Lopaschuk G.D., Important role of ventromedial hypothalamic carnitine palmitoyltransferase-1a in the control of food intake, AJP: Endocrinology and Metabolism. 2013, 305: E336-E347. |
| Keung W.W.Y., Boheler K.R. and Li R.A., Developmental cues for the maturation of metabolic, electrophysiological and calcium handling properties of human pluripotent stem cell-derived cardiomyocytes, Stem Cell Research & Therapy. 2014, 5: 17. |
| Poon N.Y.E., Yan B., Zhang S., Keung W.W.Y., Ren L., Geng L., Kong M.C.W., WANG J., Boheler K.R. and Li R.A., Transcriptome-guided functional analyses reveal novel biological properties and regulatory hierarchy of human embryonic stem cell-derived ventricular cardiomyocytes., PloS One. . 2013. |
| Ussher J.R., Keung W.W.Y., Fillmore N., Koves T.R., Mori J., Zhang L., Lopaschuk D.G., Ilkayeva O.R., Wagg C.S. and Jaswal J.S., Treatment with the 3-Ketoacyl-CoA Thiolase Inhibitor Trimetazidine Does Not Exacerbate Whole-Body Insulin Resistance in Obese Mice, Journal of Pharmacology and Experimental Therapeutics. 2014, 349: 487-496. |
| Wang J., Keung W.W.Y., Chan C.W.Y. and Li R.A., Effect of engineered anisotropy on the susceptibility of human pluripotent stem cell-derived ventricular cardiomyocytes to arrhythmias., Biomaterials. 2013. |
| Researcher : Kotaka M |
| Project Title: | Towards the understanding of hyperactivation of RIG-I signalling pathway by influenza A H5N1: Structural studies on influenza A viral RNA recognition and discrimination by RIG-I |
| Investigator(s): | Kotaka M, Hui PY |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2010 |
| Completion Date: | 01/2014 |
| Project Title: | Structural determination of Crimean-Congo Haemorrhagic Fever viral nucleocapsid protein |
| Investigator(s): | Kotaka M |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2012 |
| Completion Date: | 01/2014 |
| Project Title: | Human Dha kinase, not just an enzyme: Investigations into the molecular mechanism of its dual enzymatic activity and its role in the negative regulation of MDA5-mediated innate antiviral signaling |
| Investigator(s): | Kotaka M, Hao Q |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2013 |
| Completion Date: | 01/2014 |
| List of Research Outputs |
| CHEUNG Y.W., KWOK H.C.J., LAW W.L., Watt R.M., Kotaka M. and Tanner J.A., Structural basis for discriminatory recognition of Plasmodium lactate dehydrogenase, Proceedings of the National Academy of Sciences USA. 2013, 110(40): 15967-15972. |
| KWOK H.C.J., Hui P.Y., Lescar J. and Kotaka M., Expression, purification, crystallization and preliminary X-ray analysis of full-length human RIG-I., Acta Crystallographica Section F: Structural Biology Communications. 2014, 70: 248-251. |
| Tanner J.A., Cheung Y.W., Watt R.M. and Kotaka M., Loops, hairpins and flipped bases: a DNA aptamer that discriminates Plasmodium lactate dehydrogenase from the blind watchmaker, 9th Annual Meeting of the Oligonucleotide Therapeutics Society, Naples, Italy. 2013. |
| Tanner J.A., CHEUNG Y.W., DIRKZWAGER R.M., KINGHORN A.B. and Kotaka M., Nucleic acid aptamers against Plasmodium lactate dehydrogenase for malaria diagnosis – discovery, characterization, structure and application, FEBS Congress 2013 “Mechanisms in Biology”, St. Petersburg, Russia. 2013, FEBS J: 280 (Suppl.1) SW01.W5-30, 87. |
| Tanner J.A., Cheung Y.W., KWOK H.C.J., LAW W.L., ALBANO D.R.B., Fung Y.S., Watt R.M. and Kotaka M., Towards aptamer-mediated malaria diagnostics: structural insight into discriminatory molecular recognition by a DNA aptamer, Aptamers in Medicine and Perspectives, Naples, Italy . 2013. |
| Researcher : Kravtsov GM |
| List of Research Outputs |
| Hung M.W., Kravtsov G.M., Lau C.F., Poon A.M.S., Tipoe G.L. and Fung M.L., Melatonin ameliorates endothelial dysfunction, vascular inflammation, and systemic hypertension in rats with chronic intermittent hypoxia, Journal of Pineal Research. 2013, 55: 247-256. |
| Researcher : LAM CS |
| List of Research Outputs |
| LAM C.S., Liu Y.Y., Tipoe G.L. and Fung M.L., Induction of depressive-like behavior in a rat model of obstructive sleep apnea, The Physiology Symposium 2014, N61, 6/2014. |
| LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Cheung K.H. and Fung M.L., Lycium barbarum polysaccharides facilitate hippocampal neurogenesis induced by chronic intermittent hypoxia in rats, 18th Research Postgraduate Symposium, HKU, P5.12, 12/2013. |
| LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Chan Y.S., Cheung K.H. and Fung M.L., Mechanisms of Lycium barbarum polysaccharides against spatial memory deficits in rats exposed to chronic intermittent hpoxia, Proc. International Symposium on Physiomics p.75. 2013. |
| LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Cheung K.H. and Fung M.L., Mechanistic effects of Lycium barbarum polysaccharides against rat hippocampal injuries induced by chronic intermittent hypoxia, The 17th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, CP3, 11/2013. (Journal of the Hong Kong College of Cardiology, 21(2):69, CP3, 2013). 2013. |
| LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Cheung K.H., Chan Y.S. and Fung M.L., Neuroprotective mechanisms of Lycium barbarum polysaccharides against spatial memory impairment induced by chronic intermittent hypoxia, The Ninth International Symposium on Healthy Aging – Aging with Confidence, OP7, 3/2014. |
| Researcher : LAM KSF |
| List of Research Outputs |
| LAM K.S.F., Lai C.H. and Chan Y.S., Effect of early blockade of KCC2 on the critical period of the developing vestibular nucleus, Abstracts of 9th Int’l Symp. on Healthy Aging: Aging with Confidence: 66. 2014. |
| LAM K.S.F., DE NOGUEIRA BOTELHO F.P., Ma C.W., Lai C.H. and Chan Y.S., KCC2 co-transporter of vestibular nuclear neurons regulates the developmental expression of vestibular functions, Abstracts of Physiology Symposium 2014 & Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 70. 2014. |
| Researcher : LAW WL |
| List of Research Outputs |
| CHEUNG Y.W., KWOK H.C.J., LAW W.L., Watt R.M., Kotaka M. and Tanner J.A., Structural basis for discriminatory recognition of Plasmodium lactate dehydrogenase, Proceedings of the National Academy of Sciences USA. 2013, 110(40): 15967-15972. |
| Tanner J.A., Cheung Y.W., KWOK H.C.J., LAW W.L., ALBANO D.R.B., Fung Y.S., Watt R.M. and Kotaka M., Towards aptamer-mediated malaria diagnostics: structural insight into discriminatory molecular recognition by a DNA aptamer, Aptamers in Medicine and Perspectives, Naples, Italy . 2013. |
| Researcher : LU L |
| List of Research Outputs |
| Ballard H.J., LU L. and CAI W., Involvement of connexin hemichannels in acidosis- and exercise-induced ATP release from skeletal muscle., 37th International Union of Physiological Sciences. 2013, 531P. |
| LU L., Tu J., Cai W.S. and Ballard H.J., ATP release from rat skeletal muscle may involve chloride channels., 37th International Union of Physiological Sciences. 2013, 909P. |
| LU L., Tu J. and Ballard H.J., Connexin-hemichannels are involved in Acidosis-induced ATP Release From Skeletal Myocytes., Journal of the Hong Kong College of Cardiology. 2013, 21: 67. |
| Tu J., LU L. and Ballard H.J., Acidosis-induced ATP release from skeletal muscle involves activation of CFTR through the cAMP/PKA pathway. , 37th International Union of Physiological Sciences. 2013, 530P-531P. |
| Researcher : LU Y |
| List of Research Outputs |
| HAO B., LU Y., WANG Q., GUO W., Cheung K.H. and Yue J., Role of STIM1 in Survival and Neural Differentiation of Mouse Embryonic Stem Cells Independent of Orai1-Mediated Ca2+ Entry., Stem Cell Res. 2013, Epub ahead of print. |
| LU Y., HAO B., Graeff R.M., Wong W.M., Wu W. and Yue J., Two Pore Channel 2 (TPC2) Inhibits Autophagosomal-Lysosomal Fusion by Alkalinizing Lysosomal pH, J Biol Chem.. 2013, 288(33): 24247-63. |
| Researcher : Lai CH |
| List of Research Outputs |
| CHEN W., Ma C.W., NG K.P., HU H., DE NOGUEIRA BOTELHO F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., Early postnatal disturbance of inhibitory transmission in the vestibular nucleus impacts on the thalamic spatial map and navigation behaviors, Abstracts of Physiology Symposium 2014 & Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 61. 2014. |
| CHEN W., DE NOGUEIRA BOTELHO F.P., Ma C.W., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of GABAergic synapses in the vestibular nucleus during a postnatal critical period impacts on the acquisition on spatial recognition, Proc. International Symposium on Physiomics p. 72.. 2013. |
| CHEN W., Ma C.W., DE NOGUEIRA BOTELHO F.P., SHI W., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of GABAergic synapses in the vestibular nucleus during a postnatal critical period impacts on the acquisition on spatial recognition, Proc.10th Biennial Conference of Chinese Society for Neuroscience S05. [Beijing. Sept. 20-22, 2013]. 2013. |
| CHEN W., Ma C.W., HU H., DE NOGUEIRA BOTELHO F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of the plasticity at GABAeric synapses in the vestibular nucleus during a critical period impacts on the thalamic spatial network and navigation behavior, Abstracts of 9th Int’l Symp. on Healthy Aging: Aging with Confidence51. 2014. |
| CHEN W., SHI W., Ma C.W., Lai C.H., Shum D.K.Y. and Chan Y.S., Plasticity of GABAergic synapses in the developing vestibular nucleus governs the expression of spatial navigation in mature rats, Proc. 37th Int’l Congress of International Union of Physiological Sciences PCB120. 2013. |
| Chan Y.S., DE NOGUEIRA BOTELHO F.P., CHEN W., SHI W., Ma C.W., Lai C.H. and Shum D.K.Y., Developmental assembly of neural correlates for head directions, Proc. International Symposium on Physiomics p. 8. [Taipei. Nov 1-2, 2013]. 2013. |
| Chan Y.S., CHEN W., Ma C.W., SHI W., DE NOGUEIRA BOTELHO F.P., Lai C.H. and Shum D.K.Y., GABAergic transmission in the critical period impacts on the thalamic spatial map and navigation behaviour, Society Neuroscience Abstract (USA), 164.10/MM2. 2013. |
| Chan Y.S., CHEN W., Ma C.W., SHI W., DE NOGUEIRA BOTELHO F.P., Lai C.H. and Shum D.K.Y., Plasticity of GABAergic synapses in the developing vestibular nucleus governs the expression of spatial navigation in mature rats, Soc. Neuroscience Abstract (USA) 164.10. 2013. |
| DE NOGUEIRA BOTELHO F.P., Lai C.H. and Chan Y.S., BDNF advanced postnatal emergence of graviceptive behavior in rats by enhancing neonatal excitatory GABAergic transmission, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association35. 2014. |
| DE NOGUEIRA BOTELHO F.P., Lai C.H. and Chan Y.S., Brain derived neurotrophic factor-mediated GABAergic transmission in the vestibular nucleus modifies developmental acquisition of graviceptive behavior, Proc. 37th Int’l Congress of International Union of Physiological Sciences PCB119. 2013. |
| DE NOGUEIRA BOTELHO F.P., Ma C.W., Lai C.H. and Chan Y.S., Brain-derived neurotrophic factor (BDNF) advanced postnatal emergence of graviceptive behaviour in rats by enhancing neonatal excitatory GABAergic transmission, Abstracts of Physiology Symposium 2014 & Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 35. 2014. |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., 5-HT modulates synaptic transmission in vestibular nucleus of rats, Soc. Neuroscience Abstract (USA) 798.12 . 2013. |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., Serotonergic regulation of synaptic strength in rat medial vestibular nucleus, Proc. International Symposium on Physiomics p. 73. 2013. |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., Serotoninergic control of synaptic transmission in rat medial vestibular nucleus, Journal of Neurochemistry, 130 Suppl 1: 28. 2014. |
| JIANG Q., SHI W., DE NOGUEIRA BOTELHO F.P., Ma C.W., Lai C.H., Shum D.K.Y. and Chan Y.S., Developmental modulation of long-term plasticity at vestibular GABAergic synapses, Journal of Neurochemistry, 130 Suppl 1: 65. 2014. |
| LAM K.S.F., Lai C.H. and Chan Y.S., Effect of early blockade of KCC2 on the critical period of the developing vestibular nucleus, Abstracts of 9th Int’l Symp. on Healthy Aging: Aging with Confidence: 66. 2014. |
| LAM K.S.F., DE NOGUEIRA BOTELHO F.P., Ma C.W., Lai C.H. and Chan Y.S., KCC2 co-transporter of vestibular nuclear neurons regulates the developmental expression of vestibular functions, Abstracts of Physiology Symposium 2014 & Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 70. 2014. |
| Li C., Lai C.H. and Chan Y.S., Dorsomedial cell column mediates the spatial signals of horizontal translation in rats, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 72. 2014. |
| Ma C.W., Lai C.H., DE NOGUEIRA BOTELHO F.P., Shum D.K.Y. and Chan Y.S., Development of neural correlates of linear motion in the rat vestibular nucleus, Acta Physiologica Sinica. 2014, 66: 37-46. |
| Researcher : Lai KO |
| Project Title: | Elucidating the role of Cdk5-mediated phosphorylation of S6 kinase in synaptic plasticity |
| Investigator(s): | Lai KO |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2010 |
| Completion Date: | 03/2014 |
| List of Research Outputs |
| Lai K.O., Elucidating how cyclin-dependent kinase 5 (Cdk5) regulates synapse function in neuron, Physiology Symposium 2014 & Joint Scientific Conference of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong 2014. |
| Lai K.O. and Ip N.Y., Structural plasticity of dendritic spines: the underlying mechanisms and its dysregulation in brain disorders., Biochimica et biophysica acta.. 2013, 1832: 2257-2263. |
| Researcher : Lai SK |
| List of Research Outputs |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., 5-HT modulates synaptic transmission in vestibular nucleus of rats, Soc. Neuroscience Abstract (USA) 798.12 . 2013. |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., Serotonergic regulation of synaptic strength in rat medial vestibular nucleus, Proc. International Symposium on Physiomics p. 73. 2013. |
| Han L., Lai S.K., Lai C.H. and Chan Y.S., Serotoninergic control of synaptic transmission in rat medial vestibular nucleus, Journal of Neurochemistry, 130 Suppl 1: 28. 2014. |
| TSANG K.H., Lai S.K., Li Q., Yung W.H., LIU H., Mak H.S., NG C.P., McAlonan G.M., Chan Y.S. and Chan S.Y., The Nucleosome Assembly Protein TSPYL2 Regulates the Expression of NMDA Receptor Subunits GluN2A and GluN2B, Scientific Reports. 2014, 4: 3654. |
| Researcher : Lai SWC |
| List of Research Outputs |
| Fenelon K., Xu B., Lai S.W.C., Mukai J., Markx S., Stark K.L., Hsu P.K., Gan W.B., Fischbach G.D. and MacDermott A.B., The Pattern of Cortical Dysfunction in a Mouse Model of a Schizophrenia-Related Microdeletion, Journal of Neuroscience. 2013, 33: 14825-14839. |
| Lai S.W.C., Intravital imaging of mouse nervous system in learning and memory, International Brain Research Organization (IBRO) Advance school of Neuroscience. The Hong Kong Society of Neurosciences. . 2014. |
| Lai S.W.C., Intravital imaging of mouse nervous system in learning and memory, The Croucher Foundation Symposium. Advances in live cell and intravital imaging in biomedicine. 2014. |
| Yang G., Lai S.W.C., Cichon J., Ma L., Li W. and Gan W.B., Sleep promotes branch-specific formation of dendritic spines after learning, Science. 2014, 344: 1173-1178. |
| Researcher : Lau CF |
| List of Research Outputs |
| Hung M.W., Kravtsov G.M., Lau C.F., Poon A.M.S., Tipoe G.L. and Fung M.L., Melatonin ameliorates endothelial dysfunction, vascular inflammation, and systemic hypertension in rats with chronic intermittent hypoxia, Journal of Pineal Research. 2013, 55: 247-256. |
| Researcher : Lee HC |
| Project Title: | Regulation of the Calcium Messenger Cyclic ADP-ribose. |
| Investigator(s): | Lee HC |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2011 |
| List of Research Outputs |
| Graeff R.M. and Lee H.C., Determination of ADP-Ribosyl Cyclase Activity, Cyclic ADP-Ribose, and Nicotinic Acid Adenine Dinucleotide Phosphate in Tissue Extracts, In: Chris Gehring, Cyclic Nucleotide Signaling in Plants: Methods and Protocols, Methods in Molecular Biology. Springer, 2013, 1016: 39-56. |
| Zhao Y., Wang X. and Lee H.C., Antibody M-19 distinguishes intracellular and extracellular CD38 , 2013 FASEB SRC "NAD Metabolism & Signaling". 2013. |
| Researcher : Leung CFP |
| Project Title: | Regulation of CD38 in abscisic acid-activated human monocytes. |
| Investigator(s): | Leung CFP, Lee HC |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2009 |
| Researcher : Li RA |
| Project Title: | Cell-based Heart Regeneration |
| Investigator(s): | Li RA, Boheler KR, Chan BP, Chan CWY, Chan GCF, Chien KR, Lee HC, Yue J, Ng RK, Ngan AHW |
| Department: | Medicine |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 09/2011 |
| Project Title: | Human WT1 epicardial progenitor cells |
| Investigator(s): | Li RA |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Project Title: | Stem Cell and Regenerative Medicine |
| Investigator(s): | Li RA, Chan GCF, Tse HF |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 06/2013 |
| Project Title: | Engineering Calcium Homeostasis of hESC-derived cardiomyocytes |
| Investigator(s): | Li RA |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 07/2013 |
| List of Research Outputs |
| Keung W.W.Y., Boheler K.R. and Li R.A., Developmental cues for the maturation of metabolic, electrophysiological and calcium handling properties of human pluripotent stem cell-derived cardiomyocytes, Stem Cell Research & Therapy. 2014, 5: 17. |
| Wang J., Keung W.W.Y., Chan C.W.Y. and Li R.A., Effect of engineered anisotropy on the susceptibility of human pluripotent stem cell-derived ventricular cardiomyocytes to arrhythmias., Biomaterials. 2013. |
| Zhang L., Lui K.O., von Gise A., Ma Q., Ebina W.A.T.A.R.U., Ptaszek L.M., Später D., Xu H., Tabebordbar M., Gorbatov R., Sena B., Nahrendorf M., Briscoe D.M., Li R.A., Wagers A.J., Rossi D.J., PU W.T. and Chien K.R., Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction, Nature Biotechnology. 2013, 31: 898-907. |
| Researcher : Liu VWS |
| List of Research Outputs |
| Liu V.W.S., Tam C.W., Yao K.M. and Shiu S.Y.W., Activation of nuclear factor kappa B by androgen receptor splice variant AR-V7 in 22Rv1 Castration-resistant prostate cancer cells, Physiology Symposium 2014 & Joint Scientific Conference of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong, June 12-14, 2014. |
| Yao K.M., Lam A.K.Y., NGAN W.L., LEUNG M.H., KWOK C.T.D., Liu V.W.S., Chan D.W. and Leung W.Y.G., Differential Regulation of FOXM1 Isoforms by RAF/MEK/ERK Signaling, Gordon Research Conference: Posttranslational modification networks. 2013. |
| Researcher : Lung MAKY |
| Project Title: | Endothelins in nasal mucosa: role in nasal congestion and decongestion |
| Investigator(s): | Lung MAKY |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| List of Research Outputs |
| Lung M.A.K.Y., Acute effects of inhaled sulphur dioxide on pig nasal vascular and airway resistances., In: Zhao Zhi-Qi, Acta Physiologica Sinica. China, Beijing, Science Press, 2014, 66: 79-84. |
| Researcher : Lung MKY |
| Project Title: | Endothelins in nasal mucosa: role in nasal congestion and decongestion |
| Investigator(s): | Lung MAKY |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| List of Research Outputs |
| Researcher : Ma CW |
| Project Title: | Excitation-inhibition balance in central vestibular circuitry is critical to spatial recognition |
| Investigator(s): | Ma CW, Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2014 |
| List of Research Outputs |
| CHEN W., Ma C.W., NG K.P., HU H., DE NOGUEIRA BOTELHO F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., Early postnatal disturbance of inhibitory transmission in the vestibular nucleus impacts on the thalamic spatial map and navigation behaviors, Abstracts of Physiology Symposium 2014 & Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 61. 2014. |
| CHEN W., DE NOGUEIRA BOTELHO F.P., Ma C.W., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of GABAergic synapses in the vestibular nucleus during a postnatal critical period impacts on the acquisition on spatial recognition, Proc. International Symposium on Physiomics p. 72.. 2013. |
| CHEN W., Ma C.W., DE NOGUEIRA BOTELHO F.P., SHI W., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of GABAergic synapses in the vestibular nucleus during a postnatal critical period impacts on the acquisition on spatial recognition, Proc.10th Biennial Conference of Chinese Society for Neuroscience S05. [Beijing. Sept. 20-22, 2013]. 2013. |
| CHEN W., Ma C.W., HU H., DE NOGUEIRA BOTELHO F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of the plasticity at GABAeric synapses in the vestibular nucleus during a critical period impacts on the thalamic spatial network and navigation behavior, Abstracts of 9th Int’l Symp. on Healthy Aging: Aging with Confidence51. 2014. |
| CHEN W., SHI W., Ma C.W., Lai C.H., Shum D.K.Y. and Chan Y.S., Plasticity of GABAergic synapses in the developing vestibular nucleus governs the expression of spatial navigation in mature rats, Proc. 37th Int’l Congress of International Union of Physiological Sciences PCB120. 2013. |
| Chan Y.S., DE NOGUEIRA BOTELHO F.P., CHEN W., SHI W., Ma C.W., Lai C.H. and Shum D.K.Y., Developmental assembly of neural correlates for head directions, Proc. International Symposium on Physiomics p. 8. [Taipei. Nov 1-2, 2013]. 2013. |
| Chan Y.S., CHEN W., Ma C.W., SHI W., DE NOGUEIRA BOTELHO F.P., Lai C.H. and Shum D.K.Y., GABAergic transmission in the critical period impacts on the thalamic spatial map and navigation behaviour, Society Neuroscience Abstract (USA), 164.10/MM2. 2013. |
| Chan Y.S., CHEN W., Ma C.W., SHI W., DE NOGUEIRA BOTELHO F.P., Lai C.H. and Shum D.K.Y., Plasticity of GABAergic synapses in the developing vestibular nucleus governs the expression of spatial navigation in mature rats, Soc. Neuroscience Abstract (USA) 164.10. 2013. |
| DE NOGUEIRA BOTELHO F.P., Ma C.W., Lai C.H. and Chan Y.S., Brain-derived neurotrophic factor (BDNF) advanced postnatal emergence of graviceptive behaviour in rats by enhancing neonatal excitatory GABAergic transmission, Abstracts of Physiology Symposium 2014 & Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 35. 2014. |
| JIANG Q., SHI W., DE NOGUEIRA BOTELHO F.P., Ma C.W., Lai C.H., Shum D.K.Y. and Chan Y.S., Developmental modulation of long-term plasticity at vestibular GABAergic synapses, Journal of Neurochemistry, 130 Suppl 1: 65. 2014. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Best Poster Presentation Award, 9th Pan Pacific Connective Tissue Societies Symposium. 2013. 2013. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Certificate of Merit (Oral Presentation of poster), Physiology Symposium 2014 & Joint Scientific Conference of HKSN & BPHK.2014. 2014. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Outstanding Abstract Prize (Poster Category) , Ninth International Symposium on Healthy Aging. 2014. 2014. |
| KWAN P.Y., Ma C.W., Shum D.K.Y. and Chan Y.S., Perineuronal chondroitin sulfates and semaphorin 3A regulate postnatal maturation of the vestibular circuit for gravity detection, Abstracts of 9th Pan Pacific Connective Tissue Societies Symposium. 2013. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Postnatal Maturation of the Vestibular Circuit for Gravity Detection by under the Regulation of Perineuronal Chondroitin Sulfates and Semaphorin 3A , 18th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, December 11 & 12, 2013. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Regulatory role of perineuronal nets and semaphorin3A in the developmental maturation of the central vestibular circuitry, Abstracts of 9th FENS Forum of Neuroscience,2454. 2014. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Regulatory role of perineuronal nets and semaphoring 3A in the developmental maturation of the central vestibular circuitry, The 9th Federation of European Neuroscience Societies Forum of Neuroscience. 2014. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Semaphorin 3A Associated with Chondroitin Sulfates on Perineuronal Nets Regulates Developmental Maturation of the Central Vestibular Circuitry. , Ninth International Symposium on Healthy Aging. 2014. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Semaphorin 3A and chondroitin sulfate proteoglycan networks of perineuronal nets regulate developing central vestibular circuitry, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association69. 2014. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Semaphorin 3A and chondroitin sulphate proteoglycan networks of perineuronal nets regulate the developing central vestibular circuitry, Abstracts of Physiology Symposium 2014 & Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 69. 2014. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Semaphorin3A, Associated with Perineuronal Nets, Regulates the Development of the Maturation of the Central Vestibular Circuitry, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., The regulatory role of perineuronal nets and semaphorin 3A in the developmental maturation of the central vestibular circuitry, Abstracts of 9th Int’l Symp. on Healthy Aging: 75. 2014. |
| Kwan P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Postnatal chondroitin sulfates and semaphoring 3A regulate postnatal maturation of the vestibular circuit for gravity detection, Abstracts of 9th Pan Pacific Connective Tissue Societies Symposium P30. [HK. Nov. 24-27, 2013]. 2013. |
| Kwan P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Postnatal maturation of the vestibular circuit for gravity detection is regulated by perineuronal semaphoring 3A and chondroitin sulfates, Proc. International Symposium on Physiomics p.74. 2013. |
| LAM K.S.F., DE NOGUEIRA BOTELHO F.P., Ma C.W., Lai C.H. and Chan Y.S., KCC2 co-transporter of vestibular nuclear neurons regulates the developmental expression of vestibular functions, Abstracts of Physiology Symposium 2014 & Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 70. 2014. |
| LAU W.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Expression of heparanase 1 and heparanase 2 at the hippocampus, Abstracts of 9th FENS Forum of Neuroscience777. [Milan, Italy. July 5-9, 2014] . 2014. |
| LAU W.Y., CHAM W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Expression of heparanase 1 and heparanase 2 at the hippocampus, The 9th Federation of European Neuroscience Societies Forum of Neuroscience. 2014. |
| LAU W.Y., CHAM W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Neuronal expression of heparanase 1 and heparanase 2, Abstracts of Physiology Symposium 2014 & Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 71. 2014. |
| LAU W.Y., CHAM W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 71, Neuronal expression of heparanase 1 and heparanase 2. 2014. |
| Ma C.W., Han L., Cham W.C., Chan Y.S. and Shum D.K.Y., Neuronal proheparanase regulates synaptic function of the central vestibular system, Abstracts of 9th FENS Forum of Neuroscience 1603. 2014. |
| Ma C.W., Lai C.H., DE NOGUEIRA BOTELHO F.P., Shum D.K.Y. and Chan Y.S., Development of neural correlates of linear motion in the rat vestibular nucleus, Acta Physiologica Sinica. 2014, 66: 37-46. |
| Ma C.W., Han L., CHAM W.C., Chan Y.S. and Shum D.K.Y., Neuronal proheparanase regulates synaptic function of the central vestibular system, The 9th Federation of European Neuroscience Societies Forum of Neuroscience. 2014. |
| Ma C.W., Chan Y.S. and Shum D.K.Y., Perineuronal chondroitin sulfates regulate vestibular plasticity during development, Proc. Int’l Congress of Proteoglycans p.81. 2013. |
| Ma C.W., Lam Y.L., Cham W.C., Chan Y.S. and Shum D.K.Y., Regulatory role of neuronal proheparanase in synaptic plasticity, Proc. 37th Int’l Congress of International Union of Physiological Sciences PCB118. 2013. |
| SHI W., Ma C.W., Shum D.K.Y. and Chan Y.S., Endocannabinoid regulates long-term synaptic plasticity contributing to the acquisition of vestibular behavior during postnatal development, Abstracts of Physiology Symposium 2014 & Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 76. 2014. |
| SHI W., Ma C.W., Shum D.K.Y. and Chan Y.S., Endocannabinoid regulates long-term synaptic plasticity contributing to the acquisition of vestibular behavior during postnatal development, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 76. 2014. |
| SHI W., Ma C.W., Shum D.K.Y. and Chan Y.S., Endocannabinoid regulates the efficacy ofof vestibular inhibitory synapses contributing to the expression of gravity-detection behavior in developing rats, Proc. 10th Biennial Conference of Chinese Society for Neuroscience S15. 2013. |
| SHI W., Ma C.W., Shum D.K.Y. and Chan Y.S., The role of endocannabinoid in long-term plasticity of vestibular GABAergic synapses and behavioral outcome in developing rats., Soc. Neuroscience Abstract (USA) 129.11. [San Diego. Nov. 9-13, 2013]. 2013. |
| SHI W., Ma C.W., Shum D.K.Y. and Chan Y.S., The role of endocannabinoid in long-term plasticity of vestibular GABAergic synapses and behavioral outcome in developing rats, Society Neuroscience Abstract (USA), 129.11/C32. 2013. |
| Shum D.K.Y., Ma C.W., Lam Y.L., Chan W.C., Han L. and Chan Y.S., Novel role of proheparanase in regulating synaptic function in the central vestibular circuitry, Journal of Neurochemistry, 130 Suppl 1: 20. [11th Biennial Meeting of Asia-Pacific Society for Neurochemistry Kaohsiung. August 23-26, 2014. |
| Researcher : NG KP |
| List of Research Outputs |
| CHEN W., Ma C.W., NG K.P., HU H., DE NOGUEIRA BOTELHO F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., Early postnatal disturbance of inhibitory transmission in the vestibular nucleus impacts on the thalamic spatial map and navigation behaviors, Abstracts of Physiology Symposium 2014 & Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 61. 2014. |
| Researcher : PAN J |
| List of Research Outputs |
| GUO R., Lin B., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H. and Tipoe G.L., M30 multi-functional drug reduces apoptosis, oxidative stress and inflammation in CCl4 -induced acute liver injury animal model, The Physiology Symposium 2014, P9, 6/2014, 2014. |
| GUO R., Lin B., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H. and Tipoe G.L., M30 multi-functional drug reduces apoptosis, oxidative stress and inflammation in CCl4-induced acute liver injury animal model, The Ninth International Symposium on Healthy Aging – Aging with Confidence, P64, 3/2014. |
| PAN J., GUO R., Liong E.C., Tipoe G.L. and Fung M.L., Intermittent hypoxia exacerbates lipid accumulation, inflammation and apoptosis via NADPH oxidase in a cell model of non-alcoholic fatty liver disease, The Physiology Symposium 2014, P27, 6/2014. |
| PAN J., GUO R., Liong E.C., Tipoe G.L. and Fung M.L., Oxidative stress induced by chronic intermittent hypoxia aggravates hepatic inflammation in nonalcoholic fatty liver disease (NAFLD), 18th Research Postgraduate Symposium, HKU P5.17, 12/2013. |
| PAN J., GUO R., Liong E.C., Tipoe G.L. and Fung M.L., Oxidative stress induced by intermittent hypoxia aggravates lipid accumulation and autophagy in a cell model of nonalcoholic fatty liver disease (NAFLD), The Ninth International Symposium on Healthy Aging – Aging with Confidence, P35, 3/2014. |
| PAN J., GUO R., Liong E.C., Tipoe G.L. and Fung M.L., Oxidative stress induced by intermittent hypoxia exacerbates lipid accumulation and inflammation in HepG2 cells. 2013 International Symposium on Physiomics &Taiwan, Hong Kong Physiology Symposium. Taipei, Taiwan. 2013. |
| PAN J., GUO R., Liong E.C., Tipoe G.L. and Fung M.L., Oxidative stress induced by intermittent hypoxia exacerbates lipid accumulation and inflammation in a cell model of non-alcoholic steatohepatitis. The 17th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, OP3, 11/2013, Journal of the Hong Kong College of Cardiology. 2013, 21(2):65. |
| WU F., GUO R., PAN J., Tipoe G.L. and Fung M.L., Involvement of autophagy in the effect of exercise on left ventricular hypertrophy induced by high fat diet in rats. The 17th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, CP5, Journal of the Hong Kong College of Cardiology. 2013, 21(2):70. |
| WU F., GUO R., PAN J., Tipoe G.L. and Fung M.L., Potential role of autophagy in the effect of exercise on left ventricular hypertrophy induced by high fat diet in rats. 2013 International Symposium on Physiomics &Taiwan , Hong Kong Physiology Symposium. Taipei, Taiwan,. 2013. |
| Researcher : Poon AMS |
| List of Research Outputs |
| Hung M.W., Kravtsov G.M., Lau C.F., Poon A.M.S., Tipoe G.L. and Fung M.L., Melatonin ameliorates endothelial dysfunction, vascular inflammation, and systemic hypertension in rats with chronic intermittent hypoxia, Journal of Pineal Research. 2013, 55: 247-256. |
| Researcher : Ren L |
| Project Title: | Functional expression of sarcolemmal and mitochondrial KATP channels are a critical phenotypic determinant of human embryonic stem cell (hESC)-derived ventricular cardiomyocyte |
| Investigator(s): | Ren L, Li RA |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2013 |
| Completion Date: | 01/2014 |
| List of Research Outputs |
| Poon N.Y.E., Yan B., Zhang S., Keung W.W.Y., Ren L., Geng L., Kong M.C.W., WANG J., Boheler K.R. and Li R.A., Transcriptome-guided functional analyses reveal novel biological properties and regulatory hierarchy of human embryonic stem cell-derived ventricular cardiomyocytes., PloS One. . 2013. |
| Researcher : SHI W |
| List of Research Outputs |
| CHEN W., Ma C.W., DE NOGUEIRA BOTELHO F.P., SHI W., Lai C.H., Shum D.K.Y. and Chan Y.S., Perturbation of GABAergic synapses in the vestibular nucleus during a postnatal critical period impacts on the acquisition on spatial recognition, Proc.10th Biennial Conference of Chinese Society for Neuroscience S05. [Beijing. Sept. 20-22, 2013]. 2013. |
| CHEN W., SHI W., Ma C.W., Lai C.H., Shum D.K.Y. and Chan Y.S., Plasticity of GABAergic synapses in the developing vestibular nucleus governs the expression of spatial navigation in mature rats, Proc. 37th Int’l Congress of International Union of Physiological Sciences PCB120. 2013. |
| Chan Y.S., DE NOGUEIRA BOTELHO F.P., CHEN W., SHI W., Ma C.W., Lai C.H. and Shum D.K.Y., Developmental assembly of neural correlates for head directions, Proc. International Symposium on Physiomics p. 8. [Taipei. Nov 1-2, 2013]. 2013. |
| Chan Y.S., CHEN W., Ma C.W., SHI W., DE NOGUEIRA BOTELHO F.P., Lai C.H. and Shum D.K.Y., GABAergic transmission in the critical period impacts on the thalamic spatial map and navigation behaviour, Society Neuroscience Abstract (USA), 164.10/MM2. 2013. |
| Chan Y.S., CHEN W., Ma C.W., SHI W., DE NOGUEIRA BOTELHO F.P., Lai C.H. and Shum D.K.Y., Plasticity of GABAergic synapses in the developing vestibular nucleus governs the expression of spatial navigation in mature rats, Soc. Neuroscience Abstract (USA) 164.10. 2013. |
| JIANG Q., SHI W., DE NOGUEIRA BOTELHO F.P., Ma C.W., Lai C.H., Shum D.K.Y. and Chan Y.S., Developmental modulation of long-term plasticity at vestibular GABAergic synapses, Journal of Neurochemistry, 130 Suppl 1: 65. 2014. |
| SHI W., HU H., Shum D.K.Y. and Chan Y.S., Endocannabinoid modulates developmental plasticity of vestibular synapses and the expression of vestibular behavior in rats, Proc. 37th Int’l Congress of International Union of Physiological Sciences PCB113. [Birmingham, U.K. July 21-26, 2013]. 2013. |
| SHI W., Ma C.W., Shum D.K.Y. and Chan Y.S., Endocannabinoid regulates long-term synaptic plasticity contributing to the acquisition of vestibular behavior during postnatal development, Abstracts of Physiology Symposium 2014 & Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 76. 2014. |
| SHI W., Ma C.W., Shum D.K.Y. and Chan Y.S., Endocannabinoid regulates long-term synaptic plasticity contributing to the acquisition of vestibular behavior during postnatal development, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 76. 2014. |
| SHI W., Ma C.W., Shum D.K.Y. and Chan Y.S., Endocannabinoid regulates the efficacy ofof vestibular inhibitory synapses contributing to the expression of gravity-detection behavior in developing rats, Proc. 10th Biennial Conference of Chinese Society for Neuroscience S15. 2013. |
| SHI W., Ma C.W., Shum D.K.Y. and Chan Y.S., The role of endocannabinoid in long-term plasticity of vestibular GABAergic synapses and behavioral outcome in developing rats., Soc. Neuroscience Abstract (USA) 129.11. [San Diego. Nov. 9-13, 2013]. 2013. |
| SHI W., Ma C.W., Shum D.K.Y. and Chan Y.S., The role of endocannabinoid in long-term plasticity of vestibular GABAergic synapses and behavioral outcome in developing rats, Society Neuroscience Abstract (USA), 129.11/C32. 2013. |
| Researcher : Shiu SYW |
| Project Title: | Interactions between androgen receptor (AR) and nuclear factor kappa B (NF-κB) signaling in prostate carcinogenesis |
| Investigator(s): | Shiu SYW |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2013 |
| Project Title: | Investigating potential signaling interactions between melatonin MT1 receptor and melatonin-related GPR50 receptor, and profiling melatonin-induced genome-wide transcriptional changes in prostate cancer |
| Investigator(s): | Shiu SYW |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2014 |
| List of Research Outputs |
| Liu V.W.S., Tam C.W., Yao K.M. and Shiu S.Y.W., Activation of nuclear factor kappa B by androgen receptor splice variant AR-V7 in 22Rv1 Castration-resistant prostate cancer cells, Physiology Symposium 2014 & Joint Scientific Conference of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong, June 12-14, 2014. |
| Researcher : TAI WYE |
| List of Research Outputs |
| Leung H.Y., Tsui Y.P., Shea G.K.H., TAI W.Y.E., Chan Y.S. and Shum D.K.Y., Roles of neuregulin 1 type III in the ex vivo generation of fate committed schwann cells from bone marrow stromal cells, The 11th European Meeting on Glial Cells in Health and Disease (GLIA 2013). 2013. |
| Leung K.H.Y., Tsui Y.P., SHEA G.K.H., TAI W.Y.E., Chan Y.S. and Shum D.K.Y., Roles of neuregulin 1 type III in the ex vivo generation of fate committed Schwann cells from bone marrow stromal cells. (T06-02B), Glia 61 (Suppl): S97. 2013. |
| Shea G.K.H., TAI W.Y.E., Chan Y.S. and Shum D.K.Y., Targeting Notch signalling to generate bone marrow-derived Schwann cells for transplantation in spinal cord injury, The 33rd Annual Congress of the HKOA. 2013. |
| Shum D.K.Y., TAI W.Y.E., SHEA G.K.H., Tsui Y.P. and Chan Y.S., An emerging role of Notch signaling in the switch to fate commitment of bone marrow-derived Schwann cells, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association P.32. 2014. |
| Shum D.K.Y., Tsui Y.P., Cai S., TAI W.Y.E. and Chan Y.S., Oligodendrocyte precursors – in vitro derivation from bone marrow stromal cells and use in remyelination therapy, Proc. 10th Biennial Conference of Chinese Society for Neuroscience 15-01. [Beijing, China. Sept. 20-22, 2013]. ~ Proc. 10~th^~~ Biennial Conference of Chinese Society for Neuroscience/~~15-01, 2013. |
| Shum D.K.Y., Tsui Y.P., TAI W.Y.E. and Chan Y.S., Towards remyelination therapy with oligodendrocyte precursor and Schwann cells derived from bone marrow stromal cells, Soc. Neuroscience Abstract (USA) 414.09. 2013. |
| TAI W.Y.E., SHEA G.K.H., Tsui Y.P., Leung H.Y., Chan Y.S. and Shum D.K.Y., Fate commitment of bone marrow-derived Schwann cells is guided by Notch and ErbB signaling, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 78. 2014. |
| TAI W.Y.E., SHEA G.K.H., Tsui Y.P., Leung H.Y., Chan Y.S. and Shum D.K.Y., Guidance of DRG neurons in fate determination of bone marrow derived Schwann cells, Abstracts of 9th FENS Forum of Neuroscience, 1307. 2014. |
| TAI W.Y.E., Shea G.K.H., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Notch Signaling in in vitro derivation of Schwann cells from bone marrow stromal cells, 11th European Meeting on Glial Cells in Health and Disease. 2013. |
| TAI W.Y.E., SHEA G.K.H., Tsui Y.P., Leung K.H.Y., Chan Y.S. and Shum D.K.Y., Notch signaling in in in vitro derivation of Schwann cells from bone marrow stromal cells. (T01-12B) Glia 61 (Suppl): S55, [XI European Meeting on Glial Cells in Health and Disease Berlin, Germany. July 3 - 6, 2013]. 2013. |
| Tsui Y.P., TAI W.Y.E., Shum D.K.Y. and Chan Y.S., Divergent routes for derivation of alternative glial cell fate from bone marrow stromal cells of adult rats for remyelination, 12th Annual Meeting of the International Society for Stem Cell Research. 2014. |
| Tsui Y.P., TAI W.Y.E., Chan Y.S. and Shum D.K.Y., Divergent routes for derivation of alternative glial cell fate from bone marrow stromal cells of adult rats for remyelination, Abstracts of 12th Annual Meeting of International Society for Stem Cell Research: 470. [Vancouver, Canada. June 18-21, 2014]. 2014. |
| Tsui Y.P., TAI W.Y.E., Chan Y.S. and Shum D.K.Y., From the marrow to two glial lineages—Derivation of oligodendrocyte precursors and Schwann cells from bone marrow stromal cells for remyelination therapy, Cold Spring Harbor Asia/International Society for Stem Cell Research (CSHA/ISSCR) Joint Conference on Stem Cells in Science and Medicine. 2013. |
| Tsui Y.P., TAI W.Y.E., Shum D.K.Y. and Chan Y.S., Towards remyelination therapy: Divergent routes for derivation of alternative glial cell fate from bone marrow stromal cells of adult rats, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 80. 2014. |
| Tsui Y.P., TAI W.Y.E., Shum D.K.Y. and Chan Y.S., Towards remyelination therapy: divergent routes for derivation of alternative glial cell fate from bone marrow stromal cells of adult rats, Physiology Symposium 2014 & Joint Scientific Conference of HKSN & BPHK. 2014. |
| Researcher : Tam KV |
| List of Research Outputs |
| Tam K.V., Lee T.O., JIN J. and Chow B.K.C., Molecular Evolution of GPCRs: Secretin/secretin receptors, Journal of Molecular Endocrnology. 2014, 52(3): T1-T14. |
| Researcher : Tam KW |
| List of Research Outputs |
| Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Chondroitinase ABC-I and -II crosslinked chitosan beads improve axonal regrowth in CSPG-enriched astrocyte culture, Abstracts of 9th Int’l Symp. on Healthy Aging: Aging with Confidence: 73. 2014. |
| TUNG W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Nere guidance channel constructed by Schwann cell seeded aligned chitosan nanofiber, Journal of Neurochemistry, 130 Suppl 1: 49. 2014. |
| Tam K.W., Chan Y.S. and Shum D.K.Y., Improving the environment for axonal growth with use of recombinant chondroitinase ABC, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 78. 2014. |
| Tam K.W., Chan Y.S. and Shum D.K.Y., The dual role of combinatorial chondoritinase in overcoming the chondroitin sulfate barrier, Proc. 10th Biennial Conference of Chinese Society for Neuroscience P184. 2013. |
| Tam K.W., Chan Y.S. and Shum D.K.Y., The dual role of combinatorial chondoritinase in overcoming the chondroitin sulfate barrier, Proc. Int’l Conference on Proteoglycans p. 39. [ProteoGlycans 2013 Frankfurt/ Main, Germany. August 25-29, 2013]. 2013. |
| Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Construction of nerve guidance channel with use of Schwann cell seeded aligned chitosan nanofibers, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 81. 2014. |
| Researcher : Tang F |
| List of Research Outputs |
| Liao S., Cheung K.H., O W.S. and Tang F., Adrenomedullin Increases the Short-Circuit Current in the Mouse Seminal Vesicle: Actions on Chloride Secretion, Biology of Reproduction. 2014. |
| Liao S., Cheung K.H., Cheung M.P.L., To J.Y.T., O W.S. and Tang F., Adrenomedullin increased the short-circuit current in the pig oviduct through chloride channels via the CGRP receptor: Mediation by cAMP and calcium ions but not by nitric oxide, Biology of Reproduction. 2013, 89(4): 99, 1-6. |
| Liao S., Cheung K.H., Cheung M.P.L., Wong P.F., O W.S. and Tang F., Adrenomedullin increases the short-circuit current in the rat prostate: Receptors, chloride channels, the effects of cAMP and calcium ions and implications on fluid secretion, Andrology. 2014, 2: 474-480. |
| O W.S., Li R.H.W., Liao S., Cheung A.N.Y., Ng E.H.Y., Yeung W.S.B., Ho J.C.M. and Tang F., Decreases in adrenomedullin expression and ciliary beat frequency in the nasal epithelium in tubal pregnancy, Fertility and Sterility. 2013, 100: 459-463.e1. |
| Researcher : Tsui YP |
| Project Title: | International Society for Stem Cell Research 12th Annual Meeting; DIVERGENT ROUTES FOR DERIVATION OF ALTERNATIVE GLIAL CELL FATE FROM BONE MARROW STROMAL CELLS OF ADULT RATS FOR REMYELINATION |
| Investigator(s): | Tsui YP |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2014 |
| List of Research Outputs |
| Cai S., Tsui Y.P., Shum D.K.Y. and Chan Y.S., Fate commitment of human bone marrow stromal cells to Schwann cells, Proc. 10th Biennial Conference of Chinese Society for Neuroscience P236. 2013. |
| Cai S., Tsui Y.P., Shum D.K.Y. and Chan Y.S., Mechanism underlying fate commitment of human bone marrow stromal cells to Schwann cells, Proc. International Symposium on Physiomics p.71. [Taipei. Nov. 1-2, 2013]. 2013. |
| Leung H.Y., Tsui Y.P., Shea G.K.H., TAI W.Y.E., Chan Y.S. and Shum D.K.Y., Roles of neuregulin 1 type III in the ex vivo generation of fate committed schwann cells from bone marrow stromal cells, The 11th European Meeting on Glial Cells in Health and Disease (GLIA 2013). 2013. |
| Leung K.H.Y., Tsui Y.P., SHEA G.K.H., TAI W.Y.E., Chan Y.S. and Shum D.K.Y., Roles of neuregulin 1 type III in the ex vivo generation of fate committed Schwann cells from bone marrow stromal cells. (T06-02B), Glia 61 (Suppl): S97. 2013. |
| Lui C.N.P., Tsui Y.P., Ho A.S.L., Shum D.K.Y., Chan Y.S., Wu C.T., Li H.W., Tsang E.S.C. and Yung K.K.L., Neural Stem Cells Harvested from Live Brains by Antibody-Conjugated Magnetic Nanoparticles, Angewandte Chemie International Edition. 2013, 52: 12298–12302. |
| Shum D.K.Y., TAI W.Y.E., SHEA G.K.H., Tsui Y.P. and Chan Y.S., An emerging role of Notch signaling in the switch to fate commitment of bone marrow-derived Schwann cells, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association P.32. 2014. |
| Shum D.K.Y., Tsui Y.P., Cai S., TAI W.Y.E. and Chan Y.S., Oligodendrocyte precursors – in vitro derivation from bone marrow stromal cells and use in remyelination therapy, Proc. 10th Biennial Conference of Chinese Society for Neuroscience 15-01. [Beijing, China. Sept. 20-22, 2013]. ~ Proc. 10~th^~~ Biennial Conference of Chinese Society for Neuroscience/~~15-01, 2013. |
| Shum D.K.Y., Tsui Y.P., TAI W.Y.E. and Chan Y.S., Towards remyelination therapy with oligodendrocyte precursor and Schwann cells derived from bone marrow stromal cells, Soc. Neuroscience Abstract (USA) 414.09. 2013. |
| TAI W.Y.E., SHEA G.K.H., Tsui Y.P., Leung H.Y., Chan Y.S. and Shum D.K.Y., Fate commitment of bone marrow-derived Schwann cells is guided by Notch and ErbB signaling, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 78. 2014. |
| TAI W.Y.E., SHEA G.K.H., Tsui Y.P., Leung H.Y., Chan Y.S. and Shum D.K.Y., Guidance of DRG neurons in fate determination of bone marrow derived Schwann cells, Abstracts of 9th FENS Forum of Neuroscience, 1307. 2014. |
| TAI W.Y.E., Shea G.K.H., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Notch Signaling in in vitro derivation of Schwann cells from bone marrow stromal cells, 11th European Meeting on Glial Cells in Health and Disease. 2013. |
| TAI W.Y.E., SHEA G.K.H., Tsui Y.P., Leung K.H.Y., Chan Y.S. and Shum D.K.Y., Notch signaling in in in vitro derivation of Schwann cells from bone marrow stromal cells. (T01-12B) Glia 61 (Suppl): S55, [XI European Meeting on Glial Cells in Health and Disease Berlin, Germany. July 3 - 6, 2013]. 2013. |
| Tsui Y.P., Derivation of oligodendrocyte precursor cells from adult bone marrow stromal cells. PhD Thesis., 2013. |
| Tsui Y.P., Li R.S., Lo A.C.Y., Chan Y.S. and Shum D.K.Y., Derivation of oligodendrocyte precursor cells from bone marrow stromal cells for remyelination therapy, Proc. 37th Int’l Congress of International Union of Physiological Sciences PCB116. 2013. |
| Tsui Y.P., TAI W.Y.E., Shum D.K.Y. and Chan Y.S., Divergent routes for derivation of alternative glial cell fate from bone marrow stromal cells of adult rats for remyelination, 12th Annual Meeting of the International Society for Stem Cell Research. 2014. |
| Tsui Y.P., TAI W.Y.E., Chan Y.S. and Shum D.K.Y., Divergent routes for derivation of alternative glial cell fate from bone marrow stromal cells of adult rats for remyelination, Abstracts of 12th Annual Meeting of International Society for Stem Cell Research: 470. [Vancouver, Canada. June 18-21, 2014]. 2014. |
| Tsui Y.P., TAI W.Y.E., Chan Y.S. and Shum D.K.Y., From the marrow to two glial lineages—Derivation of oligodendrocyte precursors and Schwann cells from bone marrow stromal cells for remyelination therapy, Cold Spring Harbor Asia/International Society for Stem Cell Research (CSHA/ISSCR) Joint Conference on Stem Cells in Science and Medicine. 2013. |
| Tsui Y.P., Li R., Lo A.C.Y., Chan Y.S. and Shum D.K.Y., Towards remyelination therapy: Derivation of oligodendrocyte precursors from adult bone marrow stromal cells. (T09-11B) , Glia 61 (Suppl): S151. 2013. |
| Tsui Y.P., TAI W.Y.E., Shum D.K.Y. and Chan Y.S., Towards remyelination therapy: Divergent routes for derivation of alternative glial cell fate from bone marrow stromal cells of adult rats, Proc. Physiology Symposium 2014 cum Joint Scientific Conference of The Hong Kong Society of Neurosciences and The Hong Kong Biophysics Association: 80. 2014. |
| Tsui Y.P., TAI W.Y.E., Shum D.K.Y. and Chan Y.S., Towards remyelination therapy: divergent routes for derivation of alternative glial cell fate from bone marrow stromal cells of adult rats, Physiology Symposium 2014 & Joint Scientific Conference of HKSN & BPHK. 2014. |
| Researcher : WANG J |
| List of Research Outputs |
| Karakikes I.C., Senyei G.D., Kong M.C.W., Lieu D.K., WANG J., Jackson T., Hulot J.S., Li R.A. and Hajjar R.J., Small Molecule-Mediated Directed Differentiation of Human Embryonic Stem Cells Toward Ventricular Cardiomyocytes. Stem Cell Translational Medicine. , Stem Cells Translational Medicine. 2014, 3: 18-31. |
| Poon N.Y.E., Yan B., Zhang S., Keung W.W.Y., Ren L., Geng L., Kong M.C.W., WANG J., Boheler K.R. and Li R.A., Transcriptome-guided functional analyses reveal novel biological properties and regulatory hierarchy of human embryonic stem cell-derived ventricular cardiomyocytes., PloS One. . 2013. |
| Wang J., Keung W.W.Y., Chan C.W.Y. and Li R.A., Effect of engineered anisotropy on the susceptibility of human pluripotent stem cell-derived ventricular cardiomyocytes to arrhythmias., Biomaterials. 2013. |
| Researcher : WANG Q |
| List of Research Outputs |
| HAO B., LU Y., WANG Q., GUO W., Cheung K.H. and Yue J., Role of STIM1 in Survival and Neural Differentiation of Mouse Embryonic Stem Cells Independent of Orai1-Mediated Ca2+ Entry., Stem Cell Res. 2013, Epub ahead of print. |
| Researcher : WU F |
| List of Research Outputs |
| WU F., GUO R., Tipoe G.L. and Fung M.L., Exercise attenuates left ventricular hypertrophy induced by high fat diet in rats, 18th Research Postgraduate Symposium, HKU, P5.25, 12/2013.. 2013. |
| WU F., GUO R., PAN J., Tipoe G.L. and Fung M.L., Involvement of autophagy in the effect of exercise on left ventricular hypertrophy induced by high fat diet in rats. The 17th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, CP5, Journal of the Hong Kong College of Cardiology. 2013, 21(2):70. |
| WU F., GUO R., PAN J., Tipoe G.L. and Fung M.L., Potential role of autophagy in the effect of exercise on left ventricular hypertrophy induced by high fat diet in rats. 2013 International Symposium on Physiomics &Taiwan , Hong Kong Physiology Symposium. Taipei, Taiwan,. 2013. |
| Researcher : Wang J |
| List of Research Outputs |
| Karakikes I.C., Senyei G.D., Kong M.C.W., Lieu D.K., WANG J., Jackson T., Hulot J.S., Li R.A. and Hajjar R.J., Small Molecule-Mediated Directed Differentiation of Human Embryonic Stem Cells Toward Ventricular Cardiomyocytes. Stem Cell Translational Medicine. , Stem Cells Translational Medicine. 2014, 3: 18-31. |
| Poon N.Y.E., Yan B., Zhang S., Keung W.W.Y., Ren L., Geng L., Kong M.C.W., WANG J., Boheler K.R. and Li R.A., Transcriptome-guided functional analyses reveal novel biological properties and regulatory hierarchy of human embryonic stem cell-derived ventricular cardiomyocytes., PloS One. . 2013. |
| Wang J., Keung W.W.Y., Chan C.W.Y. and Li R.A., Effect of engineered anisotropy on the susceptibility of human pluripotent stem cell-derived ventricular cardiomyocytes to arrhythmias., Biomaterials. 2013. |
| Researcher : Wang X |
| List of Research Outputs |
| Zhao Y., Wang X. and Lee H.C., Antibody M-19 distinguishes intracellular and extracellular CD38 , 2013 FASEB SRC "NAD Metabolism & Signaling". 2013. |
| Researcher : Wong PF |
| List of Research Outputs |
| Liao S., Cheung K.H., Cheung M.P.L., Wong P.F., O W.S. and Tang F., Adrenomedullin increases the short-circuit current in the rat prostate: Receptors, chloride channels, the effects of cAMP and calcium ions and implications on fluid secretion, Andrology. 2014, 2: 474-480. |
| Researcher : Wong TM |
| Project Title: | First Asia-Pacific Opioid Symposium Cardioprotective Effects of K-Opioids |
| Investigator(s): | Wong TM |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2000 |
| Project Title: | XVIII World Congress International Society for Heart Research in Conjunction with 52nd Annual Scientific Meeting of the Cardiac Society of Australia & New Zealand Delayed Cardioprotection of Kappa Opioid Receptor Stimulation in Normal and Diabetic Rats - Roles of Heat Shock Protein 70 and Intracellular Ca2+ |
| Investigator(s): | Wong TM |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2004 |
| Project Title: | CSANZ 2006 Annual Scientific Meeting Heat Shock Protein 70, Calcium Regulation and Cardiac Survival |
| Investigator(s): | Wong TM |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2006 |
| Researcher : Yue J |
| Project Title: | Modulation of the neural lineage entry of mouse embryonic stem cells by the CD38/cADPR/Ca2+ signaling pathway |
| Investigator(s): | Yue J, Wu W |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2010 |
| Completion Date: | 09/2013 |
| Project Title: | The role of NAADP/two-pore channel 2/Ca2+ signaling in regulating neural differentiation of mouse embryonic stem cells |
| Investigator(s): | Yue J, Wu W |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2011 |
| Project Title: | Molecular mechanisms of self-renewal and neuronal differentiation of neural stem cells |
| Investigator(s): | Yue J |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2012 |
| Completion Date: | 04/2014 |
| Project Title: | The Calcium Signaling Pathway Mediated by NAADP. |
| Investigator(s): | Yue J, Lee HC, Cheung KH |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2012 |
| Completion Date: | 10/2014 |
| Project Title: | Role of TRPM2/ADPR/Ca2+ signaling in self-renewal and neurogenesis of mouse neural stem cells |
| Investigator(s): | Yue J |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2013 |
| Completion Date: | 11/2014 |
| Project Title: | 2013 ASBMB Annual Meeting; The NAADP/ TPC2/Ca2+ Signaling Antagonizes Autophagosome Maturation |
| Investigator(s): | Yue J |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2013 |
| Project Title: | Dissecting the Mechanism and Function of TPC2 Signaling in Autophagy Maturation in Mammalian Cells |
| Investigator(s): | Yue J, Wu W |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2013 |
| Project Title: | 2014 ASBMB annual meeting; Vacuolin-1 inhibits autophagy by activating rab5 |
| Investigator(s): | Yue J |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2014 |
| Completion Date: | 04/2014 |
| Project Title: | Dissecting NAADP signaling network by combining approaches of proteomics and synthetic organic chemistry |
| Investigator(s): | Yue J |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2014 |
| Completion Date: | 10/2014 |
| List of Research Outputs |
| CHE H., Yue J., Tse H.F. and Li G.R., Functional TRPV and TRPM channels in human preadipocytes, Pflügers Archiv - European Journal of Physiology. 2014, 466: 947-959. |
| HAO B., LU Y., WANG Q., GUO W., Cheung K.H. and Yue J., Role of STIM1 in Survival and Neural Differentiation of Mouse Embryonic Stem Cells Independent of Orai1-Mediated Ca2+ Entry., Stem Cell Res. 2013, Epub ahead of print. |
| LU Y., HAO B., Graeff R.M., Wong W.M., Wu W. and Yue J., Two Pore Channel 2 (TPC2) Inhibits Autophagosomal-Lysosomal Fusion by Alkalinizing Lysosomal pH, J Biol Chem.. 2013, 288(33): 24247-63. |
| ZHANG Y., Yue J., CHE H., Sun H., Tse H.F. and Li G.R., BKCa and hEag1 channels regulate cell proliferation and differentiation in human bone marrow-derived mesenchymal stem cells., J Cell Physiol. . 2013, 229(2): 202-212. |
| Researcher : Zhang H |
| Project Title: | Interaction studies of CD38 with CD4 and anti-CD38 antibodies |
| Investigator(s): | Zhang H, Hao Q |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2010 |
| Completion Date: | 10/2013 |
| Project Title: | 2nd influenza research and development; Structural Basis for RNA Binding and Homo-Oligomer Formation by Influenza B Virus Nucleoprotein |
| Investigator(s): | Zhang H |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2013 |
| Completion Date: | 07/2013 |
| Researcher : Zhao Y |
| Project Title: | Characteristics and potential regulatory mechanisms of a cytosolic CD38 |
| Investigator(s): | Zhao Y, Lee HC |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2011 |
| Project Title: | Antibody M-19 specifically recognizes intracellular CD38 |
| Investigator(s): | Zhao Y, Lee HC, Hao Q |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2012 |
| Project Title: | NAD Metabolism & Signaling; Antibody M-19 specifically recognizes intracellular CD38 |
| Investigator(s): | Zhao Y |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2013 |
| Completion Date: | 07/2013 |
| List of Research Outputs |
| Zhao Y., Wang X. and Lee H.C., Antibody M-19 distinguishes intracellular and extracellular CD38 , 2013 FASEB SRC "NAD Metabolism & Signaling". 2013. |